Deduction from Dali and Profunc: Difference between revisions
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''From Interpro'' | '''''From Interpro''''' | ||
Function of isopentenyltransferase = synthesizes isopentenyladensosine 5'-monophosphate | Function of isopentenyltransferase = synthesizes isopentenyladensosine 5'-monophosphate | ||
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Since there is a fold similarity between adenylate kinase and 2qgn, P-loop might be present. | Since there is a fold similarity between adenylate kinase and 2qgn, P-loop might be present. | ||
Adenylate kinase --> P-loop motif is formed between a β-strand and a α-helix, at its N-terminus. | |||
From PDB and Profunc, | From PDB and Profunc, | ||
- ligand interacts with AVGKT at position 775-780 | - ligand interacts with AVGKT at position 775-780 | ||
- | - This is towards the end-terminus of the protein sequence and | ||
- | - This sequence is between a β-strand and a α-helix (PDBsum) | ||
Guanylate kinase has a P-loop as well but different pattern from adenylate kinase. | Guanylate kinase has a P-loop as well but different pattern from adenylate kinase. | ||
- | - Divergence of the P-loop motif | ||
This accounts for the fact that 2qgn cannot be superimposed onto guanylate kinase | This accounts for the fact that 2qgn cannot be superimposed onto guanylate kinase |
Revision as of 05:28, 10 June 2008
From Interpro
Function of isopentenyltransferase = synthesizes isopentenyladensosine 5'-monophosphate
Function of adenylate kinase and guanylate kinase= catalyzes the ATP-dependent phosphorylation of GMP into GDP
Also, -found a P-loop pattern in adenylate kinase and guanylate kinase
-P-loop is said to be involved in ATP/GTP binding
Since there is a fold similarity between adenylate kinase and 2qgn, P-loop might be present.
Adenylate kinase --> P-loop motif is formed between a β-strand and a α-helix, at its N-terminus.
From PDB and Profunc, - ligand interacts with AVGKT at position 775-780 - This is towards the end-terminus of the protein sequence and - This sequence is between a β-strand and a α-helix (PDBsum)
Guanylate kinase has a P-loop as well but different pattern from adenylate kinase. - Divergence of the P-loop motif This accounts for the fact that 2qgn cannot be superimposed onto guanylate kinase