Bifunctional coenzyme A synthase (CoA synthase) Structure Main: Difference between revisions
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'''Coenzyme A Atomic structures:''' | |||
Coenzyme A atomic structure by bfactor (flexibility as denoted by crystalography; red is more flexible, blue is more structurally stable) | Coenzyme A atomic structure by bfactor (flexibility as denoted by crystalography; red is more flexible, blue is more structurally stable) | ||
[[Image:COASYCoa atomic struct by bfactor.JPG]] | [[Image:COASYCoa atomic struct by bfactor.JPG]] | ||
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[[Image:COASYCoa atomic struct.JPG]] | [[Image:COASYCoa atomic struct.JPG]] | ||
'''Coenzyme A Ribbon structures:''' | |||
Coenzyme A ribbon structure with water molecules | Coenzyme A ribbon structure with water molecules | ||
[[Image:COASYWatermolecules.JPG]] | [[Image:COASYWatermolecules.JPG]] | ||
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[[Image:COASYConformationtypes.JPG]] | [[Image:COASYConformationtypes.JPG]] | ||
Binding Sites and types for AcetylCoenzymeA ligand to CoenzymeA | '''Binding Sites and types for AcetylCoenzymeA ligand to CoenzymeA:''' | ||
Hydrophilic binding sites | |||
[[Image:COASYAcohydrophilicres.JPG]] | [[Image:COASYAcohydrophilicres.JPG]] | ||
[[Image:COASYAcohydrophilic.JPG]] | [[Image:COASYAcohydrophilic.JPG]] | ||
Hydrophobic binding sites | |||
[[Image:COASYAcohydrophobicres.JPG]] | [[Image:COASYAcohydrophobicres.JPG]] | ||
[[Image:COASYAcohydrophobic.JPG]] | [[Image:COASYAcohydrophobic.JPG]] | ||
[[Image: | |||
Bridged H bond binding sites | |||
[[Image:COASYAcobridgedhbond.JPG]] | |||
Other binding sites | |||
[[Image:COASYAcootherres.JPG]] | [[Image:COASYAcootherres.JPG]] | ||
[[Image:COASYAcoother.JPG]] | [[Image:COASYAcoother.JPG]] | ||
Binding Sites and types for unknown ligand UNL to CoenzymeA | '''Binding Sites and types for unknown ligand UNL to CoenzymeA:''' | ||
Hydrophilic binding sites | |||
[[Image:COASYUnlhydrophilicres.JPG]] | [[Image:COASYUnlhydrophilicres.JPG]] | ||
[[Image:COASYUnlhydrophilic.JPG]] | [[Image:COASYUnlhydrophilic.JPG]] | ||
Bridged H bond binding sites | |||
[[Image:COASYUnlbridgedbondhres.JPG]] | [[Image:COASYUnlbridgedbondhres.JPG]] | ||
[[Image:COASYUnlbridgedbondh.JPG]] | [[Image:COASYUnlbridgedbondh.JPG]] | ||
Other binding sites | |||
[[Image:COASYUnlotherres.JPG]] | [[Image:COASYUnlotherres.JPG]] | ||
[[Image:COASYUnlother.JPG]] | [[Image:COASYUnlother.JPG]] |
Revision as of 06:17, 15 May 2007
Coenzyme A Atomic structures: Coenzyme A atomic structure by bfactor (flexibility as denoted by crystalography; red is more flexible, blue is more structurally stable)
Coenzyme A Ribbon structures: Coenzyme A ribbon structure with water molecules
Coenzyme A ribbon structure by hydrophobicity
Coenzyme A ribbon structure by compound type
Coenzyme A ribbon structure by conformation/structural type
Binding Sites and types for AcetylCoenzymeA ligand to CoenzymeA: Hydrophilic binding sites
Binding Sites and types for unknown ligand UNL to CoenzymeA: Hydrophilic binding sites
Highly Structurally Related Proteins:
Thymidylate Kinase: Nucleoside monophosphate kinase. Catalyses reversible phosphorylation transfer between ATP & TMP > ADP & TDP. Activates Anti HIV prodrugs.
Shikimate Kinase: Target for nontoxic antimicrobial agents, herbicides and parasite drugs. Absent in mammals. Catalyses reaction of phosphoryltransfer from ATP to shikimic acid.
Adenylate Kinase: Nucleoside monophosphate kinase. Essential for bacterial survival. AMP(bd) domain close to core of structure. Low catalytic activity compared to eukaryotic kinases (10 fold slower).
Dephospho-COA Kinase: Uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose (final stages of biosynthesis). ATP binds in p-loop (as it does in other kinases). COA binding site located at join of all 3 domains.
UMP/CMP kinase: Supplies precursors for nucleic acid synthesis. Catalyses UMP,CMP & dCMP into diphosphate form. Component of nucleoside analog prodrugs (AraC, gemcitabine & ddC).
Uridine-Cystidine Kinase: Catalyses phosphorylation of uridine & cystidine. Upon cystidine binding UCK becomes strictly specific to pyramidine ribnucleotides.