Bifunctional coenzyme A synthase (CoA synthase) Structure Main: Difference between revisions
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=='''Coenzyme A Synthase PHD Functional Site Prediction'''== | =='''Coenzyme A Synthase PHD Functional Site Prediction'''== | ||
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Pattern-ID: ASN_GLYCOSYLATION PS00001 PDOC00001 | Pattern-ID: ASN_GLYCOSYLATION PS00001 PDOC00001<BR> | ||
Pattern-DE: N-glycosylation site | Pattern-DE: N-glycosylation site<BR> | ||
Pattern: N[^P][ST][^P] | Pattern: N[^P][ST][^P]<BR> | ||
34 NHTL | 34 NHTL<BR> | ||
Pattern-ID: GLYCOSAMINOGLYCAN PS00002 PDOC00002 | Pattern-ID: GLYCOSAMINOGLYCAN PS00002 PDOC00002<BR> | ||
Pattern-DE: Glycosaminoglycan attachment site | Pattern-DE: Glycosaminoglycan attachment site<BR> | ||
Pattern: SG.G | Pattern: SG.G<BR> | ||
367 SGSG | 367 SGSG<BR> | ||
Pattern-ID: PKC_PHOSPHO_SITE PS00005 PDOC00005 | Pattern-ID: PKC_PHOSPHO_SITE PS00005 PDOC00005<BR> | ||
Pattern-DE: Protein kinase C phosphorylation site | Pattern-DE: Protein kinase C phosphorylation site<BR> | ||
Pattern: [ST].[RK] | Pattern: [ST].[RK]<BR> | ||
173 TIR | 173 TIR<BR> | ||
183 SPK | 183 SPK<BR> | ||
245 TER | 245 TER<BR> | ||
291 TYR | 291 TYR<BR> | ||
335 SFR | 335 SFR<BR> | ||
369 SGK | 369 SGK<BR> | ||
541 TQR | 541 TQR<BR> | ||
Pattern-ID: CK2_PHOSPHO_SITE PS00006 PDOC00006 | Pattern-ID: CK2_PHOSPHO_SITE PS00006 PDOC00006<BR> | ||
Pattern-DE: Casein kinase II phosphorylation site | Pattern-DE: Casein kinase II phosphorylation site<BR> | ||
Pattern: [ST].{2}[DE] | Pattern: [ST].{2}[DE]<BR> | ||
324 TENE | 324 TENE<BR> | ||
534 TLWE | 534 TLWE<BR> | ||
Pattern-ID: MYRISTYL PS00008 PDOC00008 | Pattern-ID: MYRISTYL PS00008 PDOC00008<BR> | ||
Pattern-DE: N-myristoylation site | Pattern-DE: N-myristoylation site<BR> | ||
Pattern: G[^EDRKHPFYW].{2}[STAGCN][^P] | Pattern: G[^EDRKHPFYW].{2}[STAGCN][^P]<BR> | ||
194 GAVGGT | 194 GAVGGT<BR> | ||
277 GSDPSL | 277 GSDPSL<BR> | ||
295 GMAINR | 295 GMAINR<BR> | ||
365 GISGSG | 365 GISGSG<BR> | ||
505 GLSEAA | 505 GLSEAA<BR> | ||
Pattern-ID: AMIDATION PS00009 PDOC00009 | Pattern-ID: AMIDATION PS00009 PDOC00009<BR> | ||
Pattern-DE: Amidation site | Pattern-DE: Amidation site<BR> | ||
Pattern: .G[RK][RK] | Pattern: .G[RK][RK]<BR> | ||
462 EGKR | 462 EGKR<BR> | ||
Pattern-ID: ATP_GTP_A PS00017 PDOC00017 | Pattern-ID: ATP_GTP_A PS00017 PDOC00017<BR> | ||
Pattern-DE: ATP/GTP-binding site motif A (P-loop) | Pattern-DE: ATP/GTP-binding site motif A (P-loop)<BR> | ||
Pattern: [AG].{4}GK[ST] | Pattern: [AG].{4}GK[ST]<BR> | ||
365 GISGSGKS | 365 GISGSGKS<BR> | ||
Pattern-ID: UPF0038 PS01294 PDOC00996 | Pattern-ID: UPF0038 PS01294 PDOC00996<BR> | ||
Pattern-DE: Uncharacterized protein family UPF0038 signature | Pattern-DE: Uncharacterized protein family UPF0038 signature<BR> | ||
Pattern: G.[LI].R.{2}L.{4}F.{8}[LIV].{5}P.[LIV] | Pattern: G.[LI].R.{2}L.{4}F.{8}[LIV].{5}P.[LIV]<BR> | ||
419 GIINRKVLGSRVFGNKKQLKILTDIMWPII | 419 GIINRKVLGSRVFGNKKQLKILTDIMWPII<BR> | ||
=='''Coenzyme A Atomic structures:'''== | =='''Coenzyme A Atomic structures:'''== |
Revision as of 04:29, 22 May 2007
Coenzyme A Synthase PHD Functional Site Prediction
Pattern-ID: ASN_GLYCOSYLATION PS00001 PDOC00001
Pattern-DE: N-glycosylation site
Pattern: N[^P][ST][^P]
34 NHTL
Pattern-ID: GLYCOSAMINOGLYCAN PS00002 PDOC00002
Pattern-DE: Glycosaminoglycan attachment site
Pattern: SG.G
367 SGSG
Pattern-ID: PKC_PHOSPHO_SITE PS00005 PDOC00005
Pattern-DE: Protein kinase C phosphorylation site
Pattern: [ST].[RK]
173 TIR
183 SPK
245 TER
291 TYR
335 SFR
369 SGK
541 TQR
Pattern-ID: CK2_PHOSPHO_SITE PS00006 PDOC00006
Pattern-DE: Casein kinase II phosphorylation site
Pattern: [ST].{2}[DE]
324 TENE
534 TLWE
Pattern-ID: MYRISTYL PS00008 PDOC00008
Pattern-DE: N-myristoylation site
Pattern: G[^EDRKHPFYW].{2}[STAGCN][^P]
194 GAVGGT
277 GSDPSL
295 GMAINR
365 GISGSG
505 GLSEAA
Pattern-ID: AMIDATION PS00009 PDOC00009
Pattern-DE: Amidation site
Pattern: .G[RK][RK]
462 EGKR
Pattern-ID: ATP_GTP_A PS00017 PDOC00017
Pattern-DE: ATP/GTP-binding site motif A (P-loop)
Pattern: [AG].{4}GK[ST]
365 GISGSGKS
Pattern-ID: UPF0038 PS01294 PDOC00996
Pattern-DE: Uncharacterized protein family UPF0038 signature
Pattern: G.[LI].R.{2}L.{4}F.{8}[LIV].{5}P.[LIV]
419 GIINRKVLGSRVFGNKKQLKILTDIMWPII
Coenzyme A Atomic structures:
Coenzyme A Synthase atomic structure by bfactor (flexibility as denoted by crystalography; red is more flexible, blue is more structurally stable)
Coenzyme A Synthase atomic structure
Coenzyme A Synthase Ribbon structures:
Coenzyme A ribbon structure with water molecules
Coenzyme A Synthase ribbon structure by hydrophobicity
Coenzyme A Synthase ribbon structure by compound type
Coenzyme A Synthase ribbon structure by conformation/structural type
Binding Sites and types for AcetylCoenzymeA ligand to CoenzymeA Synthase:
Binding Sites and types for unknown ligand UNL to CoenzymeA Synthase:
Highly Structurally Related Proteins:
Thymidylate Kinase: Nucleoside monophosphate kinase. Catalyses reversible phosphorylation transfer between ATP & TMP > ADP & TDP. Activates Anti HIV prodrugs.
Shikimate Kinase: Target for nontoxic antimicrobial agents, herbicides and parasite drugs. Absent in mammals. Catalyses reaction of phosphoryltransfer from ATP to shikimic acid.
Adenylate Kinase: Nucleoside monophosphate kinase. Essential for bacterial survival. AMP(bd) domain close to core of structure. Low catalytic activity compared to eukaryotic kinases (10 fold slower).
Dephospho-COA Kinase: Uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose (final stages of biosynthesis). ATP binds in p-loop (as it does in other kinases). COA binding site located at join of all 3 domains.
UMP/CMP kinase: Supplies precursors for nucleic acid synthesis. Catalyses UMP,CMP & dCMP into diphosphate form. Component of nucleoside analog prodrugs (AraC, gemcitabine & ddC).
Uridine-Cystidine Kinase: Catalyses phosphorylation of uridine & cystidine. Upon cystidine binding UCK becomes strictly specific to pyramidine ribnucleotides.