Coenzyme A Synthase's Relation To Other Structurally Related Proteins: Difference between revisions
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|[[Image:COASYSecondary structure with bind sites.gif|framed|The secondary structure of ''Mus musculus'' with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005|none]] | |[[Image:COASYSecondary structure with bind sites.gif|framed|The secondary structure of ''Mus musculus'' with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005|none]] | ||
|Top 14 structurally related were all Kinases and some examples are: | |||
• Thymidylate Kinase | |||
o Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP. | |||
• Shikimate Kinase | |||
o Which catalyses reaction of phosphoryltransfer from ATP to shikimic acid and this is mainly found in plants. | |||
• Adenylate Kinase | |||
o Which catalyzes the production of ATP from ADP. | |||
• Dephospho-COA Kinase | |||
o Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway. | |||
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|colspan="2"|[[Image:COASYSecondary structure comparsion.jpg|thumb|900px|Structural comparison of Dephospho-COA Kinase (IJJV) and Bifunctional coenzyme A synthase from ''Mus musculus'' (2F6R) with bound ATP.|none]] | |colspan="2"|[[Image:COASYSecondary structure comparsion.jpg|thumb|900px|Structural comparison of Dephospho-COA Kinase (IJJV) and Bifunctional coenzyme A synthase from ''Mus musculus'' (2F6R) with bound ATP.|none]] |
Revision as of 18:10, 11 June 2007
Top 14 structurally related were all Kinases and some examples are:
• Thymidylate Kinase o Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP. • Shikimate Kinase o Which catalyses reaction of phosphoryltransfer from ATP to shikimic acid and this is mainly found in plants. • Adenylate Kinase o Which catalyzes the production of ATP from ADP. • Dephospho-COA Kinase o Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway. | |