Phytanoyl-CoA dioxygenase Sequence and Evolution

Fasta Sequence

>gi|134105315|pdb|2OPW|A Chain A, Crystal Structure Of Human Phytanoyl-Coa Dioxygenase Phyhd1 (Apo) MACLSPSQLQKFQQDGFLVLEGFLSAEECVAMQQRIGEIVAEMDVPLHCRTEFSTQEEEQLRAQGSTDYF LSSGDKIRFFFEKGVFDEKGNFLVPPEKSINKIGHALHAHDPVFKSITHSFKVQTLARSLGLQMPVVVQS MYIFKQPHFGGEVSPHQDASFLYTEPLGRVLGVWIAVEDATLENGCLWFIPGSHTSGVSRRMVRAPVGSA PGTSFLGSEPARDNSLFVPTPVQRGALVLIHGEVVHKSKQNLSDRSRQAYTFHLMEASGTTWSPENWLQP TAELPFPQLYT

Multiple Sequence Alignment

• 46 analogous sequence compared using ClustalX
• Multiple Sequence Alignment is of high quality and conservation
• Fe2+ and 2-Oxogylterate binding sites shown

Figure 1.1
Multiple Sequence Alignment obtained from ClustalX

Figure 1.2
Multiple Sequence Alignment obtained from ClustalX

Figure 1.3
Multiple Sequence Alignment obtained from ClustalX

Phylogenetic Trees

Figure 2.1
Rooted Phylogenetic Tree obtained from Phylip
Drawn using Phylodendron
http://iubio.bio.indiana.edu/treeapp/

Figure 2.1
Unrooted Phylogenetic Tree obtained from Phylip
Drawn using Phylodendron
http://iubio.bio.indiana.edu/treeapp/

Figure 3
Rooted Consensus Tree with bootstrap values obtained from Phylip
Drawn using Phylodendron
http://iubio.bio.indiana.edu/treeapp/

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