Bifunctional coenzyme A synthase (CoA synthase) Structure Main

Coenzyme A atomic structure by bfactor (flexibility as denoted by crystalography; red is more flexible, blue is more structurally stable)

Coenzyme A atomic structure

Coenzyme A ribbon structure with water molecules

Coenzyme A ribbon structure by hydrophobicity

Coenzyme A ribbon structure by compound type

Coenzyme A ribbon structure by conformation/structural type

Binding Sites and types for AcetylCoenzymeA ligand to CoenzymeA

File:COASYAcobridgedbondh.JPG

Binding Sites and types for unknown ligand UNL to CoenzymeA

Dali Table For Z > 7

Highly Structurally Related Proteins:

Thymidylate Kinase: Nucleoside monophosphate kinase. Catalyses reversible phosphorylation transfer between ATP & TMP > ADP & TDP. Activates Anti HIV prodrugs.

Shikimate Kinase: Target for nontoxic antimicrobial agents, herbicides and parasite drugs. Absent in mammals. Catalyses reaction of phosphoryltransfer from ATP to shikimic acid.

Adenylate Kinase: Nucleoside monophosphate kinase. Essential for bacterial survival. AMP(bd) domain close to core of structure. Low catalytic activity compared to eukaryotic kinases (10 fold slower).

Dephospho-COA Kinase: Uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose (final stages of biosynthesis). ATP binds in p-loop (as it does in other kinases). COA binding site located at join of all 3 domains.

UMP/CMP kinase: Supplies precursors for nucleic acid synthesis. Catalyses UMP,CMP & dCMP into diphosphate form. Component of nucleoside analog prodrugs (AraC, gemcitabine & ddC).

Uridine-Cystidine Kinase: Catalyses phosphorylation of uridine & cystidine. Upon cystidine binding UCK becomes strictly specific to pyramidine ribnucleotides.

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