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| Gene expression is highly regulated by complex protein translation systems. Expression within the eukaryotic cell is especially complicated, involving the mature mRNA, the ribosomal subunits and other protein factors. Furthermore, each component has to interact in a specific function i.e. the small ribosomal subunit has to recognise a start codon, and the large ribosomal subunit has to be recruited before translation can be initiated (Wagner et al.YEAR). One such protein is the eukaryotic translation initiation factor 4G (eIF4G), which participates in the recruiting of the small 40S ribosomal subunit and in scanning along the 5' UTR of the mRNA to the translation start codon. Other regulatory proteins which interact in tandem with the eIF4G include the 5'-cap-binding protein eIF4E and RNA helicase eIF4A.
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| An MIF4G-like protein from the zebrafish was studied for its functional, structural and evolutionary properties. Preliminary information provided by the crystal structure of the protein revealed it to be similar to the middle domain of the eIF4G protein, hence described as "MIF4G-like protein". Subsequent research into the MIF4G protein is presented in this report.
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| * I think we should have some information here about the eIF domain. Ie that is consists of x number of domains of which MIF4G is the middle domain. etc. Maybe some information on what this does (although we mostly have that anyway). I will do something on this and add it. if thats ok with everyone - if not let me know. :)
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