Arylformamidase Structure: Difference between revisions
No edit summary |
|||
Line 65: | Line 65: | ||
TM1040_2226 | TM1040_2226 Tryptophan 2,3-dioxygenase (279 aa) | ||
TM1040_2225 | TM1040_2225 Kynureninase (396 aa) | ||
TM1040_2493 Succinic semialdehyde dehydrogenase (490 aa) | |||
TM1040_1862 Hypothetical protein (212 aa) | |||
TM1040_2491 Creatinase (402 aa) | |||
TM1040_2736 Transketolase, putative (794 aa) | |||
== '''4. DALI OUTPUT''' == | == '''4. DALI OUTPUT''' == |
Revision as of 08:05, 20 May 2008
1. Structure of Arylformamidase
Arylformamidase
The image above shows the chains A (upper right), B (upper left), C (lower right) & D (lower left) interacting. The molecules in the middle of chains A & B and chains C & D is phosphate ion (PO4). The green molecule between chain B & D is a magnesium ion (Mg).
Chain A of arylformamidase
The red molecule in the middle is an unknown ligand containing a ring composed of 9 oxygen molecules. The green sphere is a chloride ion.
2. Putative Thioesterase
Thioesterases split ester groups into acid and alcohol in the presence of water, specifically at a thiol group.
Thioesterases or thiolester hydrolases are members of E.C.3.1.2.
Our structure resembles carboxylesterases (hydrolases) hence it is predicted that it has similar cellular activity.
3. Interaction of human arylformamidase (AFMID) with other proteins
The interaction between the proteins have been determined from curated STRING database (significant score). However there is no significant evidence for:
1- Neighborhood in the genome
2- Gene fusions
3- Cooccurence across genomes
4- Co-Expression
5- Experimental/Biochemical data
4. Interaction of Silicibacter Sp. arylformamidase (AFMID) with other proteins
TM1040_2226 Tryptophan 2,3-dioxygenase (279 aa)
TM1040_2225 Kynureninase (396 aa)
TM1040_2493 Succinic semialdehyde dehydrogenase (490 aa)
TM1040_1862 Hypothetical protein (212 aa)
TM1040_2491 Creatinase (402 aa)
TM1040_2736 Transketolase, putative (794 aa)
4. DALI OUTPUT
Metagenomic Archea Carboxylesterase A chain
PDB link title
Archaeoglobus fulgidus Carboxylesterase (Chains A B C D)
File:Carboxylesterase (archaeon).txt
PDB link title
5. Secondary structure analysis
PDBSum output for arylformamidase
PDBSUM [1]
Archeon Carboxylesterase secondary structure