Evolution
Query Sequences (2gfh)
mgsdkihhhh hhmglsrvra vffdldntli dtagasrrgm levikllqsk yhykeeaeii
cdkvqvklsk ecfhpystci tdvrtshwee aiqetkggad nrklaeecyf lwkstrlqhm
iladdvkaml telrkevrll lltngdrqtq rekieacacq syfdaivigg eqkeekpaps
ifyhccdllg vqpgdcvmvg dtletdiqgg lnaglkatvw inksgrvplt sspmphymvs
svlelpallq sidckvsmsv
Multiple Sequence Alignments (msa)
Figure 20. The schematic diagrams of glycolysis and pentose phosphate metabolic pathways. The green arrows show the substrates that are hydrolyzed by HADs (A) Glycolysis pathway with substrates that are hydrolyze by HADs: glucose 6-phosphate, fructose 6-phosphate and dihydroxyacetone phosphate. (B) Pentose phostphate pathway with substrates that are hydrolyze by HADs: glucose-6-phosphate, fructose-6-phosphate, dihydroxyacetone phosphate, glyceraldehyde-3-phosphate, gluconate 6-phosphate and erythrose-4-phosphate.
Catalytic activity | N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate |
Cofactor | Magnesium (By similarity) |
Enzyme regulation | Inhibited by vanadate and calcium (By similarity) |
Pathway | Carbohydrate metabolism; aminosugar metabolism |
Similarity | Belongs to the haloacid dehalogenase-like hydrolase superfamily. NANP family |