Coenzyme A Synthase's Relation To Other Structurally Related Proteins

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The secondary structure of Mus musculus with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005
 Top 14 structurally related were all Kinases and some examples are:
  • Thymidylate Kinase
    • Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP.
  • Shikimate Kinase
    • Which catalyses reaction of phosphoryltransfer from ATP to shikimic acid and this is mainly found in plants.
  • Adenylate Kinase
    • Which catalyzes the production of ATP from ADP.
  • Dephospho-COA Kinase
    • Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway.
Structural comparison of Dephospho-COA Kinase (IJJV) and Bifunctional coenzyme A synthase from Mus musculus (2F6R) with bound ATP.

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