Function: Siowwei
Results on Function Analysis
Table 2.1 Complete annotation of NUBP2 retrieved from UnitProtKB/Swiss-Prot
Names and origin
Protein names | Nucleotide-binding protein 2Also known as: NBP 2 | ||
Gene names |
| ||
Organism | Homo sapiens (Human) |
General annotation (Comments)
Function | May contribute to formation of bipolar spindles (By similarity). |
Subunit structure | Binds NUBP1 and KIFC1 (By similarity). |
Subcellular location | Nucleus (By similarity). Note=Associated with nucleus during interphase and nucleocytoplasm surrounding mitotic spindles during early mitosis. Enriched around centrosomes during late mitosis (By similarity). |
Tissue specificity | Widely expressed with highest expression in skeletal muscle. |
Developmental stage | Expressed in fetal brain, lung, liver and kidney. |
Sequence similarities | Belongs to the Mrp/NBP35 ATP-binding proteins family. |
Ontologies
Keywords | |
Cellular component | Nucleus |
Ligand | ATP-bindingNucleotide-binding |
Gene Ontology (GO) | |
Molecular function | Nucleotide binding
Traceable author statement. Source: ProtInc |
Sequence annotation (Features)
Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
Chain | 271
|
Nucleotide-binding protein 2 |
| |||||
Regions | ||||||||
Nucleotide binding | 8
|
ATP Potential |
|
Table 2.2 Aligned sequence of 2ph1 protein
Aligned Sequences:
%-tage
Seq. id. identity Name
-------- -------- ----
Query - - Query sequence
O30288 100.0 - O30288 Nucleotide-binding protein.
O28015 79.8 - O28015 Nucleotide-binding protein.
B1I1P7 54.1 - B1I1P7 Putative uncharacterized protein precursor.
A5N3E5 50.7 - A5N3E5 Predicted nucleotide-binding protein.
B0ACV7 55.7 - B0ACV7 Putative uncharacterized protein.
A8SJJ8 43.5 - A8SJJ8 Putative uncharacterized protein.
O27244 49.6 - O27244 Nucleotide-binding protein (Putative ATPase).
Q3AQ21 48.3 - Q3AQ21 ATP-binding protein, Mrp/Nbp35 family.
Q48LT6 45.3 - Q48LT6 ATP-binding protein, Mrp/Nbp35 family.
A1RYM9 46.4 - A1RYM9 MRP protein-like protein.
Table 2.3 The diagram and table below show the 3 sequence motifs found in the sequence
[[Image:]] |
[[Image:|thumb|{| class="prettytable" | colspan="6" | |
Table 2.4 The diagram and table below show the 1 sequence of superfamily found in the sequence
[[Image:]] |
[[Image:|thumb|{| class="prettytable" | colspan="7" | |- | Hit | 1 | |
Figure 1. Protein-protein interactions search using 2ph1 sequence
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AF2381 |
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• | • | 0.927 | |||||||||||||||||||
AF2380 |
|
• | 0.894 | ||||||||||||||||||||
metG |
|
• | • | 0.827 | |||||||||||||||||||
AF2378 |
|
• | 0.808 | ||||||||||||||||||||
AF_2379 |
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• | 0.808 | ||||||||||||||||||||
AF2383 |
|
• | 0.729 | ||||||||||||||||||||
AF2377 |
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• | 0.704 | ||||||||||||||||||||
AF1185 |
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• | 0.485 | ||||||||||||||||||||
suhB |
|
• | • | 0.472 | |||||||||||||||||||
AF2385 |
|
Figure 2. Protein-protein interactions search using NUBP2 sequence
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IGFALS |
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• | 0.675 | ||||||||||||||||||||
MAPK8IP3 |
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• | 0.673 | ||||||||||||||||||||
REG3G |
|
• | 0.619 | ||||||||||||||||||||
ENSP00000262027 |
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• | • | 0.594 | |||||||||||||||||||
RANBP1 |
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• | 0.525 | ||||||||||||||||||||
KIF11 |
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• | 0.514 | ||||||||||||||||||||
SEPP1 |
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• | 0.491 | ||||||||||||||||||||
NR3C2 |
|
• | 0.477 | ||||||||||||||||||||
CYPA |
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• | 0.443 | ||||||||||||||||||||
WDR39 |
|
• | • | 0.414 |
Figure 3. NUBP2 expressions in human and mouse tissues
[[Image:]]