3b5q Function: Difference between revisions

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Protein data base profile characteris arylsulfatase asa hydrolase and a sulfatase. A hydrolase is an enzyme which hydrolyses a chemical bond. The general reaction can be shown as follows.
Group of ydrolaes are named as '''EC 3''' in enzyme classification.
== 1. Function of sulfatases ==
== 1. Function of sulfatases ==



Revision as of 02:56, 21 May 2008

Protein data base profile characteris arylsulfatase asa hydrolase and a sulfatase. A hydrolase is an enzyme which hydrolyses a chemical bond. The general reaction can be shown as follows.



Group of ydrolaes are named as EC 3 in enzyme classification.




1. Function of sulfatases

Sulfatases are enzymes,which hydrolyse sulfate ester bonds of substrates. Most of the family members has shown to contain a highly conserved cystine residue and a bivalent metal binding site.


2. Functional site

MSA data revealed some conserved residues on the sequence. They were mapped on the three dimantional structure.

Zn Cl surface.png
























3. Arylsulfatase K (BT1596) Interactions with other proteins

Net.png


Input Protein

  • BT1596 Putative sulfatase yidJ (481 aa) of Bacteroides thetaiotaomicron.

Predicted Functional Partners

  • BT3796: Putative secreted sulfatase ydeN (518 aa).
  • BT1595 Transcription termination factor rho (722 aa).
  • BT1597 Two-component system sensor histidine kinase (539 aa).
  • BT3057 N-acetylgalactosamine-6-sulfatase (508 aa).
  • BT1598 Putative two-component system sensor histidine (655 aa).
  • BT3101 N-sulphoglucosamine sulphohydrolase (455 aa).
  • BT3489 Arylsulfatase B {UniProtKB/TrEMBL-Q8A219} (458 aa).





























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