ATP binding domain 4

Introductions

Methods

Discussions

Dali-Arginosuccinate synthase- pp-loop- function- catalyse hydrolysis of AB bond of ATP. RXN same wt atp pyrophosphatase ATP binding domain 4 probably binds ATP –conserved motif SGGKD at the N terminus Argininosuccinate synthetase works by: L-citrullin + L-Asp + ATP = AMP + PP +

Substrate might be involved in tRNA replication Function can be inferred based on structures of the proteins-compare structures from available structures. Based on the comparison – found PP-loop- local structural motifs which are conserved across all species

Ab initio prediction of function

ATP binding domain 4 Functions

ATP binding domain 4 Structures

ATP binding domain 4 Evolution