ATP binding domain 4 Discussions: Difference between revisions
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Based on SCOP hierarchy (Superfamily HMM library and genome assignments server)it was found that all three domain: Archaea, Bacteria and Eukaryote belong to superfamily Adenine nucleotide alpha hydrolases-like (AANH-like). The family members in this superfamily include PP-ATPase, Alpha-ANH-like and Arginosuccinate synthase. Based on the phylogeny of ATP binding domain 4 | Based on SCOP hierarchy (Superfamily HMM library and genome assignments server)it was found that all three domain: Archaea, Bacteria and Eukaryote belong to superfamily Adenine nucleotide alpha hydrolases-like (AANH-like). The family members in this superfamily include PP-ATPase, Alpha-ANH-like and Arginosuccinate synthase. Based on the phylogeny of ATP binding domain 4 which is a type of putative N-type PP-ATPase, clan bacteria is missing, suggesting that bacteria do not use ATP pyrophosphatase (PP-ATPase)but it may use other type of protein or enzymes in the superfamily to hydrolyse ATP. | ||
There are several other families of ATP pyrophosphatase which do not contain the PP motifs and it is likely they are not homologous to the family. some enzymes appear to contain other version of PP-loop that despite the predicted structural analogy, do not overlap with the PP-motif described here in any database searches (Bork and Koonin, 1994). | There are several other families of ATP pyrophosphatase which do not contain the PP motifs and it is likely they are not homologous to the family. some enzymes appear to contain other version of PP-loop that despite the predicted structural analogy, do not overlap with the PP-motif described here in any database searches (Bork and Koonin, 1994). | ||
[[ATP binding domain 4 | Back to Main ATP binding domain 4 pages]] | [[ATP binding domain 4 | Back to Main ATP binding domain 4 pages]] | ||
Revision as of 06:35, 2 June 2009
Based on SCOP hierarchy (Superfamily HMM library and genome assignments server)it was found that all three domain: Archaea, Bacteria and Eukaryote belong to superfamily Adenine nucleotide alpha hydrolases-like (AANH-like). The family members in this superfamily include PP-ATPase, Alpha-ANH-like and Arginosuccinate synthase. Based on the phylogeny of ATP binding domain 4 which is a type of putative N-type PP-ATPase, clan bacteria is missing, suggesting that bacteria do not use ATP pyrophosphatase (PP-ATPase)but it may use other type of protein or enzymes in the superfamily to hydrolyse ATP.
There are several other families of ATP pyrophosphatase which do not contain the PP motifs and it is likely they are not homologous to the family. some enzymes appear to contain other version of PP-loop that despite the predicted structural analogy, do not overlap with the PP-motif described here in any database searches (Bork and Koonin, 1994).
