Abstract 2ece

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Selenium binding protein is apart of the SBP56 superfamily of 56kDa selenium binding proteins. It consists of 8% helices (7 in total) and 40% beta sheets (36 in total). The protein can be found in a wide variety of organisms with evidence to support lateral gene transfer. We predicted it to be involved in the metabolism of toxic levels of selenium which is in line with transportation in and around the golgi apparatus as reported by in literature. It could also be invovled in the immune systems defenses against cancer since its strucuture was found to be similar to many proteins that function as molecular anticarcinogens like nucleoporins and clathrins. These proteins are involved in apoptoptic mechanisms of eliminatin cancerous cells.

The project was completed with a number of tools for each aspect. Bioinformatic databases such as pubmed, genbank, uniprot and pdb were utilised to gather literature information, programs including psiblast, clustulx, protdist, neighbor, treeview and consense were used to analyse the gene homology, while Dali and PDBsum were used to analyse the structure. The functions were determined using literature and programs such as profunc. These tools were essential in creating this report and obtaining the conclusions drawn from it.

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