Abstract of SNAPG

Soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) has three different form of isoforms; alpha-,beta- and gamma-. The SNAP family can be found on the cellular compartment; membrane and peripheral membrane protein. The SNAP-gamma functions are still under investigations unlike the other two isoforms. Structure-based alignment with vesicular transport protein sec17 in yeast has shown many similar physical properties suggesting that these proteins may also have similar interaction pattern with ligands and/or other proteins. However, SNAP-gamma and sec17 sequence alignment was problematic as it was difficult to acquire optimal alignment for conserved active site investigations.