Abstract to haloacid dehalogenase-like hydrolase domain containing 2: Difference between revisions

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Digging information about the functions of proteins whose structures have been determined by functional genomics can be a challenging task. However, once the bits and pieces have been collected from the various databases with biological information and the bioinformatics tools, it is possible to uncover the functions of the proteins.
Digging information about the functions of proteins whose structures have been determined by functional genomics can be a challenging task. However, once the bits and pieces have been collected from the various databases with biological information and the bioinformatics tools, it is possible to uncover the biological functions of such proteins. Using methods for structural, functional, and evolutionary analysis, we determined the possible function of the haloacid dehalogenase-like hydrolase domain containing 2, which may be refered to as 2HO4 (PDB code). 2HO4 is a member of the haloacid dehalogeanse (HAD) superfamily, and all members have three highly-conserved motifs. It presumably is a P-type ATPase involved Mg2+ dependent phosphatase activity, and is mainly expressed in the immune system and the CNS. One possible function of 2HO4 is to transport ions across ion channels. Moreover, its sequence appears to be conserved amongst well studied animals, with the mouse version closest to the ancestral gene. The findings of this paper characterize some structural, functional, and evolutionary aspects of the haloacid dehalogenase-like hydrolase domain containing 2, but further research is warranted.
 
The web-based information provided by functional genomics
 
Understanding the biological function of novel proteins
 
 
The haloacid dehalogenase-like hydrolase domain containing 2

Revision as of 05:28, 11 June 2007

Digging information about the functions of proteins whose structures have been determined by functional genomics can be a challenging task. However, once the bits and pieces have been collected from the various databases with biological information and the bioinformatics tools, it is possible to uncover the biological functions of such proteins. Using methods for structural, functional, and evolutionary analysis, we determined the possible function of the haloacid dehalogenase-like hydrolase domain containing 2, which may be refered to as 2HO4 (PDB code). 2HO4 is a member of the haloacid dehalogeanse (HAD) superfamily, and all members have three highly-conserved motifs. It presumably is a P-type ATPase involved Mg2+ dependent phosphatase activity, and is mainly expressed in the immune system and the CNS. One possible function of 2HO4 is to transport ions across ion channels. Moreover, its sequence appears to be conserved amongst well studied animals, with the mouse version closest to the ancestral gene. The findings of this paper characterize some structural, functional, and evolutionary aspects of the haloacid dehalogenase-like hydrolase domain containing 2, but further research is warranted.