Arylformamidase: Difference between revisions

From MDWiki
Jump to navigationJump to search
No edit summary
No edit summary
 
(65 intermediate revisions by 4 users not shown)
Line 1: Line 1:
'''FASTA sequence of protein'''
[[Image:Pretty protein.PNG|centre|framed|'''Figure 1.''' ''2PBL'']]


>gi|146387357|pdb|2PBL|A Chain A, Crystal Structure Of Putative Thioesterase (Yp_614486.1) From Silicibacter Sp. Tm1040 At 1.79 A Resolution
''by Basma Al Alaiwat, Sebastian Mynott and Thomas Parker''
GXELDDAYANGAYIEGAADYPPRWAASAEDFRNSLQDRARLNLSYGEGDRHKFDLFLPEGTPVGLFVFVH
GGYWXAFDKSSWSHLAVGALSKGWAVAXPSYELCPEVRISEITQQISQAVTAAAKEIDGPIVLAGHSAGG
HLVARXLDPEVLPEAVGARIRNVVPISPLSDLRPLLRTSXNEKFKXDADAAIAESPVEXQNRYDAKVTVW
VGGAERPAFLDQAIWLVEAWDADHVIAFEKHHFNVIEPLADPESDLVAVITA


>gi|58330909|ref|NP_001010982.1| arylformamidase [Homo sapiens]
== Abstract ==
MMDVSGVGFPSKVPWKKMSAEELENQYCPSRWVVRLGAEEALRTYSQIGIEATTRARATRKSLLHVPYGD
GEGEKVDIYFPDESSEALPFFLFFHGGYWQSGSKDESAFMVHPLTAQGVAVVIVAYGIAPKGTLDHMVDQ
VTRSVAFVQKRYPSNKGIYLCGHSAGAHLAAMMLLADWTKHGVTPNLRGFFLVSGVFDLEPIVYTSQNVA
LQLTLEDAQRNNPQLKVAQAQPVDPTCRVLVVVGQFDSPEFHRQSWEFYQVLPVQTLCQGEWKASFEELH
DVDHFEIVENLTQKDNVLTQIILKTIFQ


[[Arylformamidase Sequence & Homology]]
2PBL, initially annotated as an arylformamidase, was isolated from ''Silicibacter sp. TM1040'' and its structure determined by the JCSG. Based on structural, functional and evolutionary analysis, we have further characterised 2PBL. It was found to contain a conserved functional region present in A/B-hydrolases of many taxonomic groups. Specifically, it was found to share similar structural and sequence characteristics of the prokaryotic HSL family of esterases. Residues of a probable catalytic triad were identified as Ser137, His242 and Glu215. Further experimental characterisation of 2PBL is required to better understand its function.


[[Arylformamidase Structure]]
== Contents ==


[[Arylformamidase Function & Literature]]
[[Arylformamidase Introduction|Introduction]]
 
[[Arylformamidase Results|Results]]
 
[[Arylformamidase Discussion|Discussion]]
 
[[Arylformamidase Methods|Methods]]
 
[[Arylformamidase Additional Materials|Additional Materials]]
 
[[Arylformamidase References|References]]
 
== Presentations ==
 
[[Arylformamidase Sequence & Homology | Sequence & Homology]] - ''Sebastian Mynott''
 
[[Arylformamidase Structure | Structure]] - ''Basma Al Alaiwat''
 
[[Arylformamidase Function Slide 1 | Function]] - ''Thomas Parker''

Latest revision as of 03:29, 10 June 2008

Figure 1. 2PBL

by Basma Al Alaiwat, Sebastian Mynott and Thomas Parker

Abstract

2PBL, initially annotated as an arylformamidase, was isolated from Silicibacter sp. TM1040 and its structure determined by the JCSG. Based on structural, functional and evolutionary analysis, we have further characterised 2PBL. It was found to contain a conserved functional region present in A/B-hydrolases of many taxonomic groups. Specifically, it was found to share similar structural and sequence characteristics of the prokaryotic HSL family of esterases. Residues of a probable catalytic triad were identified as Ser137, His242 and Glu215. Further experimental characterisation of 2PBL is required to better understand its function.

Contents

Introduction

Results

Discussion

Methods

Additional Materials

References

Presentations

Sequence & Homology - Sebastian Mynott

Structure - Basma Al Alaiwat

Function - Thomas Parker

Retrieved from "http://compbio.biosci.uq.edu.au/mediawiki/index.php?title=Arylformamidase&oldid=10839"