Arylformamidase Function Slide 5: Difference between revisions

Latest revision as of 23:33, 9 June 2008

- Catalytic triad identified in paper - Ser154, Asp251, and His281.

- To assess functional similarity, conservation of the catalytic triad was analysed.

DALI alignment showing conservation of the catalytic triad between 2C7B and 2PBL.

- Similar level of conservation as noted between 2PBL and arylformamidase.

@@ Line 1: / Line 1: @@
-== Commonalities between mechanisms? ==
+== Evidence from Similar Structures ==
+- Catalytic triad identified in paper - Ser154, Asp251, and His281.
-[[Image:Arylformadisae_reaction.gif|centre|framed|'''Figure 4:''' ''The reaction catalysed by Arylformamidase.'']]
+- To assess functional similarity, conservation of the catalytic triad was analysed.
-Carboxylesterases have a common reaction mechanism (see figure ...). This is somewhat similar to the arylformamidase reaction mechanism incorporating hydrolysis of a ... bond.
+[[Image:Catalytic triad conversation.PNG|centre|framed|'''DALI alignment showing conservation of the catalytic triad between 2C7B and 2PBL.''']]
- [[Image:Carboxylesterase_reaction.gif|centre|framed|'''Figure 2:''' ''The fundamental reaction catalysed by carboxylesterases.'']]
+- Similar level of conservation as noted between 2PBL and arylformamidase.
-Evolutionary...
+[[Arylformamidase Function Slide 4| ...Previous slide ]]|[[Arylformamidase| Return to the main page ]]|[[Arylformamidase Function Slide 6| Next slide... ]]
-[[Arylformamidase Function Slide 3| ...Previous slide ]]|[[Arylformamidase| Return to the main page ]]|[[Arylformamidase Function Slide 5| Next slide... ]]