Arylformamidase Function Slide 6

Similarity in mechanism?

The reaction catalysed by Arylformamidase.

The fundamental reaction catalysed by carboxylesterases.

Thermostable?

Structural similarity

 No:  Chain   Z    rmsd lali nres  %id  Description
  1:  2pbl-A 52.4  0.0  262   262  100   MOLECULE: PUTATIVE ESTERASE/LIPASE/THIOESTERASE;                     
  5:  2c7b-A 23.4  3.0  231   294   16   MOLECULE: CARBOXYLESTERASE;                                          
  9:  1jji-A 23.0  3.1  233   311   15   MOLECULE: CARBOXYLESTERASE;                                          
 14:  1evq-A 21.4  2.9  225   308   18   MOLECULE: SERINE HYDROLASE;                                          

Sequence similarity

Alignment with thermophillic HSL family members identified by Byun 2007.

Ecology - an aquatic organism widely present throughout world's oceans.

The Putative Function Refined

Exact function difficult to specify.

Broad range of functions performed by HSLs.

May be a thermostable carboxylesterase.

Applications?

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