Arylformamidase Function Slide 7: Difference between revisions

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== Thermostable? ==
== Identification of family. ==


'''Structural similarity'''
- Byun, et al. (2007) alluded to the HSL family of lipases.


  No:  Chain  Z    rmsd lali nres  %id  Description
- All known structures of the HSL family of esterases (Byun, et al. 2007) are present in the DALI search.
  1:  2pbl-A 52.4  0.0  262  262  100  MOLECULE: PUTATIVE ESTERASE/LIPASE/THIOESTERASE;                   
  5:  2c7b-A 23.4  3.0  231  294  16  MOLECULE: CARBOXYLESTERASE;                                         
  9:  1jji-A 23.0  3.1  233  311  15  MOLECULE: CARBOXYLESTERASE;                                         
  14:  1evq-A 21.4  2.9  225  308  18  MOLECULE: SERINE HYDROLASE;                                         


'''Sequence similarity'''
[[Image:DAL_HSLs.png|centre|framed|'''Structures of the HSL family of esterases as identified by Byun, et al. (2007) present in the DALI results.''']]


[[Image:HSL_alignment.png|centre|framed|'''Alignment with thermophillic HSL family members identified by Byun 2007.''']]
- 2pbl shares sequence similarity in regions characteric to the HSL family of esterases (Arpigny and Jaeger 1999).


'''Ecology''' - an aquatic organism widely present throughout world's oceans.
[[Image:HSL_alignment.png|centre|framed|'''Sequence similarity in regions characteristic to the HSL family of esterases as identified by Arpigny and Jaeger (1999).''']]


== The Putative Function Refined ==
- Characterised by their sequence similarity to the mammalian hormone sensitive lipase. Surprisingly, a mammalian HSL was not returned in the BLAST search.


Exact function difficult to specify.  
- Association may be purely structural.


Broad range of functions performed by HSLs.
May be a thermostable carboxylesterase.
Applications?


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Latest revision as of 14:07, 8 June 2008

Identification of family.

- Byun, et al. (2007) alluded to the HSL family of lipases.

- All known structures of the HSL family of esterases (Byun, et al. 2007) are present in the DALI search.

Structures of the HSL family of esterases as identified by Byun, et al. (2007) present in the DALI results.

- 2pbl shares sequence similarity in regions characteric to the HSL family of esterases (Arpigny and Jaeger 1999).

Sequence similarity in regions characteristic to the HSL family of esterases as identified by Arpigny and Jaeger (1999).

- Characterised by their sequence similarity to the mammalian hormone sensitive lipase. Surprisingly, a mammalian HSL was not returned in the BLAST search.

- Association may be purely structural.


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