Arylformamidase Function Slide 7: Difference between revisions

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== Thermostable? ==
== Identification of family. ==


Byun, et al. (2007) identified a number of HSL family members with thermostable properties.
- Byun, et al. (2007) alluded to the HSL family of lipases.


[[Image:DALI2pbl.png|centre|framed|'''Thermophillic HSL family members as identified by Byun, et al. 2007 found in the DALI search performed by Basma.''']]
- All known structures of the HSL family of esterases (Byun, et al. 2007) are present in the DALI search.


[[Image:HSL_alignment.png|centre|framed|'''ClustalW alignment of 2pbl with thermophillic HSL family members as identified by Byun 2007.''']]
[[Image:DAL_HSLs.png|centre|framed|'''Structures of the HSL family of esterases as identified by Byun, et al. (2007) present in the DALI results.''']]


- Similar structure and sequence.
- 2pbl shares sequence similarity in regions characteric to the HSL family of esterases (Arpigny and Jaeger 1999).
 
[[Image:HSL_alignment.png|centre|framed|'''Sequence similarity in regions characteristic to the HSL family of esterases as identified by Arpigny and Jaeger (1999).''']]
 
- Characterised by their sequence similarity to the mammalian hormone sensitive lipase. Surprisingly, a mammalian HSL was not returned in the BLAST search.
 
- Association may be purely structural.


- '''Ecological evidence:''' Weak - an aquatic organism widely present throughout world's oceans.


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Latest revision as of 14:07, 8 June 2008

Identification of family.

- Byun, et al. (2007) alluded to the HSL family of lipases.

- All known structures of the HSL family of esterases (Byun, et al. 2007) are present in the DALI search.

Structures of the HSL family of esterases as identified by Byun, et al. (2007) present in the DALI results.

- 2pbl shares sequence similarity in regions characteric to the HSL family of esterases (Arpigny and Jaeger 1999).

Sequence similarity in regions characteristic to the HSL family of esterases as identified by Arpigny and Jaeger (1999).

- Characterised by their sequence similarity to the mammalian hormone sensitive lipase. Surprisingly, a mammalian HSL was not returned in the BLAST search.

- Association may be purely structural.


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