Arylformamidase Structure: Difference between revisions

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This image was generated from "STRING" database.
The interaction between the proteins have been determined from curated STRING database. However there is no significant evidence for:


1- Neighborhood in the genome
2- Gene fusions   
3- Cooccurence across genomes 
4- Co-Expression   
5- Experimental/Biochemical data





Revision as of 07:44, 20 May 2008

1. Structure of Arylformamidase

Arylformamidase


Whole protein.png

The image above shows the chains A (upper right), B (upper left), C (lower right) & D (lower left) interacting. The molecules in the middle of chains A & B and chains C & D is phosphate ion (PO4). The green molecule between chain B & D is a magnesium ion (Mg).



Chain A of arylformamidase


Chain A.jpg

The red molecule in the middle is an unknown ligand containing a ring composed of 9 oxygen molecules. The green sphere is a chloride ion.



2. Putative Thioesterase

Thioesterases split ester groups into acid and alcohol in the presence of water, specifically at a thiol group.

Thioesterases or thiolester hydrolases are members of E.C.3.1.2.

Our structure resembles carboxylesterases (hydrolases) hence it is predicted that it has similar cellular activity.



3. Interaction of human arylformamidase (AFMID) with other proteins

Confidence interaction with names.png


The interaction between the proteins have been determined from curated STRING database. However there is no significant evidence for:

1- Neighborhood in the genome

2- Gene fusions

3- Cooccurence across genomes

4- Co-Expression

5- Experimental/Biochemical data


4. DALI OUTPUT

File:DALI RESULT.txt



Metagenomic Archea Carboxylesterase A chain

Carboxylase A chain.PNG

File:Carboxylase.txt

PDB link title


Archaeoglobus fulgidus Carboxylesterase (Chains A B C D)

Archeaon Carboxylesterase.PNG

File:Carboxylesterase (archaeon).txt

PDB link title



5. Secondary structure analysis

PDBSum output for arylformamidase

PDBSum pblA.PNG

PDBSUM [1]


Archeon Carboxylesterase secondary structure

PDBsums.png



6. Topology

Topology.gif

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