Bifunctional coenzyme A synthase (CoA synthase) Structure Main: Difference between revisions
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'''[[Bifunctional coenzyme A synthase (CoA synthase) Structure Dali |Dali Table For Z > 7]]''' | '''[[Bifunctional coenzyme A synthase (CoA synthase) Structure Dali |Dali Table For Z > 7]]''' | ||
'''Highly Structurally Related Proteins:''' | |||
''Thymidylate Kinase:'' | |||
Nucleoside monophosphate kinase. | |||
Catalyses reversible phosphorylation transfer between ATP & TMP > ADP & TDP. | |||
Activates Anti HIV prodrugs. | |||
''Shikimate Kinase:'' | |||
Target for nontoxic antimicrobial agents, herbicides and parasite drugs. | |||
Absent in mammals. | |||
Catalyses reaction of phosphoryltransfer from ATP to shikimic acid. | |||
''Adenylate Kinase:'' | |||
Nucleoside monophosphate kinase. | |||
Essential for bacterial survival. | |||
AMP(bd) domain close to core of structure. | |||
Low catalytic activity compared to eukaryotic kinases (10 fold slower). | |||
''Dephospho-COA Kinase:'' | |||
Uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose (final stages of biosynthesis). | |||
ATP binds in p-loop (as it does in other kinases). | |||
COA binding site located at join of al 3 domains. | |||
''UMP/CMP kinase:'' | |||
Supplies precursors for nucleic acid synthesis. | |||
Catalyses UMP,CMP & dCMP into diphosphate form. | |||
Component of nucleoside analog prodrugs (AraC, gemcitabine & ddC). | |||
''Uridine-Cystidine Kinase'' | |||
Catalyses phosphorylation of uridine & cystidine. | |||
Upon cystidine binding UCK becomes strictly specific to pyramidine ribnucleotides. |
Revision as of 06:01, 8 May 2007
Highly Structurally Related Proteins:
Thymidylate Kinase: Nucleoside monophosphate kinase. Catalyses reversible phosphorylation transfer between ATP & TMP > ADP & TDP. Activates Anti HIV prodrugs.
Shikimate Kinase: Target for nontoxic antimicrobial agents, herbicides and parasite drugs. Absent in mammals. Catalyses reaction of phosphoryltransfer from ATP to shikimic acid.
Adenylate Kinase: Nucleoside monophosphate kinase. Essential for bacterial survival. AMP(bd) domain close to core of structure. Low catalytic activity compared to eukaryotic kinases (10 fold slower).
Dephospho-COA Kinase: Uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose (final stages of biosynthesis). ATP binds in p-loop (as it does in other kinases). COA binding site located at join of al 3 domains.
UMP/CMP kinase: Supplies precursors for nucleic acid synthesis. Catalyses UMP,CMP & dCMP into diphosphate form. Component of nucleoside analog prodrugs (AraC, gemcitabine & ddC).
Uridine-Cystidine Kinase Catalyses phosphorylation of uridine & cystidine. Upon cystidine binding UCK becomes strictly specific to pyramidine ribnucleotides.