C1orf41 Introduction
Bioinformatics is an important tool in acquiring new information on uncharacterized proteins usually based on their sequence and sometimes their structure. Databases and programs such as Protein Data Bank, Interpro, BLAST, ClustalX and DALI contributes to the growing knowledge about proteins and their functions. This project aims at predicting the function of an unknown protein based on its sequence and structure by utilizing the various bioinformatics tools available.
Our protein of interest is known as chromosome 1 open reading frame 41 (c1orf41) which is a 153 amino acids long protein and was isolated from human term placentas. This protein was encoded by gene on chromosome 1 locus 1p32.1-p33. Besides c1orf41, this protein is also known as Pp25, Hspc034, Hsp16.2 and HspB11 (Bellyei et al., 2007; Bohn & Winkler, 1991). From PDB, it was stated that this protein is a mutant due to deletion of aspartic acid at position 109.
