Chromosome 1 open reading frame 41 Function

C1orf41

Based on Blast result, our protein has high similarity with sHsp, specifically with sHsp 16.2. Thus, they may have similar function.

sHsp function:

1. Molecular chaperone function

Under cellular stress (heat or chemical stress), sHsp will prevent protein aggregation and precipitation by interact with & stabilize the targeted protein.

Bellyei et al(2007) tested the chaperoning function of sHsp 16.2. They determined the thermal resistance of E. coli over-expressing sHsp 16.2 or aHsp27. The result showed that the sHsp 16.2 over expressing E. coli were resistant against heat stress (increase number of surviving colonies) compared to E. coli not expressing sHsp.

2. Cytoprotective Function

sHsp inhibit cell deaths by:

• Stabilizing the mitochondria system

sHsp interact with various component of programmed cell death machinery. It prevent the release of proapoptotic protein (caspase-3 and cytochrome c)within the mitochondria.

• Increasing the Akt phosphorylation.

Akt is a cytoprotective protein kinase which inactivates the tumor suppressor through phosphorylation-dependent process.

Based on the structure analysis, C1orf41 has a loop which binds to Ca2+. The presence of Ca2+ presumably related to Akt phosphorylation (support the phosphorylation).

Based on experimental evidence, there was an interaction between c1orf41 and RAYL (Ras-like-GTPase superfamily member).

• Overexpression of Ras GTPase activating protein will enhance the phosphorylation & activity of Akt.

sHsp play as antiapoptotic protein. Thus, it is highly express in cancer

---

Based on Pfam result, the domain of our protein target (1tvg) is F5/8 (discoidin).

Back to main page