Coenzyme A Synthase's Relation To Other Structurally Related Proteins: Difference between revisions

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|[[Image:COASYSecondary structure with bind sites.gif|framed|The secondary structure of ''Mus musculus'' with indicated ligand interaction sites (EMBL EBI, 2005).|none]]
|[[Image:COASYSecondary structure with bind sites.gif|framed|The secondary structure of ''Mus musculus'' with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005|none]]
|'''Top fourteen structurally related proteins were all Kinases and some examples are:'''
<BR>
* ''Thymidylate Kinase''
** Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP.
<BR>
* ''Shikimate Kinase''
** Which is found in plants and bacteria and catalyses reaction of phosphoryltransfer from ATP to shikimic acid.
<BR>
* ''Adenylate Kinase''
** Which catalyzes the production of ATP from ADP.
<BR>
* ''Dephospho-COA Kinase''
** Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway.
<BR>
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|colspan="2"|[[Image:COASYSecondary structure comparsion.jpg|thumb|800px|Structural comparison of Dephospho-COA Kinase (IJJV) and Bifunctional coenzyme A synthase from ''Mus musculus'' (2F6R) with bound ATP.|none]]
|colspan="2"|[[Image:COASYSecondary structure comparsion.jpg|thumb|900px|Structural comparison of Dephospho-COA Kinase (IJJV) and Bifunctional coenzyme A synthase from ''Mus musculus'' (2F6R) with bound ATP.|none]]
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[[Coenzyme A Synthase DPCK Domain Defining The P-Loop|Next]]
[[Coenzyme A Synthase DPCK Domain Defining The P-Loop|Next]] |
[[BiFunctional Coenzyme A Synthase's Structure and Domains|Previous page]]
[[BiFunctional Coenzyme A Synthase's Structure and Domains|Previous]]

Latest revision as of 18:16, 11 June 2007

The secondary structure of Mus musculus with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005
 Top fourteen structurally related proteins were all Kinases and some examples are:


  • Thymidylate Kinase
    • Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP.


  • Shikimate Kinase
    • Which is found in plants and bacteria and catalyses reaction of phosphoryltransfer from ATP to shikimic acid.


  • Adenylate Kinase
    • Which catalyzes the production of ATP from ADP.


  • Dephospho-COA Kinase
    • Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway.


Structural comparison of Dephospho-COA Kinase (IJJV) and Bifunctional coenzyme A synthase from Mus musculus (2F6R) with bound ATP.

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