Coenzyme A Synthase's Relation To Other Structurally Related Proteins: Difference between revisions

Revision as of 18:10, 11 June 2007


The secondary structure of Mus musculus with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005	Top 14 structurally related were all Kinases and some examples are: • Thymidylate Kinase o Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP. • Shikimate Kinase o Which catalyses reaction of phosphoryltransfer from ATP to shikimic acid and this is mainly found in plants. • Adenylate Kinase o Which catalyzes the production of ATP from ADP. • Dephospho-COA Kinase o Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway.
Structural comparison of Dephospho-COA Kinase (IJJV) and Bifunctional coenzyme A synthase from Mus musculus (2F6R) with bound ATP.

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 |[[Image:COASYSecondary structure with bind sites.gif|framed|The secondary structure of ''Mus musculus'' with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005|none]]
+|Top 14 structurally related were all Kinases and some examples are:
+•	Thymidylate Kinase
+o	Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP.
+•	Shikimate Kinase
+o	Which catalyses reaction of phosphoryltransfer from ATP to shikimic acid and this is mainly found in plants.
+•	Adenylate Kinase
+o	Which catalyzes the production of ATP from ADP.
+•	Dephospho-COA Kinase
+o	Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway.
 |-
 |colspan="2"|[[Image:COASYSecondary structure comparsion.jpg|thumb|900px|Structural comparison of Dephospho-COA Kinase (IJJV) and Bifunctional coenzyme A synthase from ''Mus musculus'' (2F6R) with bound ATP.|none]]