Coenzyme A Synthase's Relation To Other Structurally Related Proteins: Difference between revisions

From MDWiki
Jump to navigationJump to search
No edit summary
mNo edit summary
Line 5: Line 5:
|[[Image:COASYSecondary structure with bind sites.gif|framed|The secondary structure of ''Mus musculus'' with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005|none]]
|[[Image:COASYSecondary structure with bind sites.gif|framed|The secondary structure of ''Mus musculus'' with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005|none]]
|Top 14 structurally related were all Kinases and some examples are:
|Top 14 structurally related were all Kinases and some examples are:
• Thymidylate Kinase
* Thymidylate Kinase
o Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP.
** Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP.
• Shikimate Kinase
* Shikimate Kinase
o Which catalyses reaction of phosphoryltransfer from ATP to shikimic acid and this is mainly found in plants.
** Which catalyses reaction of phosphoryltransfer from ATP to shikimic acid and this is mainly found in plants.
• Adenylate Kinase
* Adenylate Kinase
o Which catalyzes the production of ATP from ADP.
** Which catalyzes the production of ATP from ADP.
• Dephospho-COA Kinase
* Dephospho-COA Kinase
o Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway.
** Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway.


|-
|-

Revision as of 18:11, 11 June 2007

The secondary structure of Mus musculus with indicated ligand interaction sites. Reproduced from, EMBL EBI, 2005
 Top 14 structurally related were all Kinases and some examples are:
  • Thymidylate Kinase
    • Which catalyses reversible phosphorylation transfer from ATP & TMP to ADP & TDP.
  • Shikimate Kinase
    • Which catalyses reaction of phosphoryltransfer from ATP to shikimic acid and this is mainly found in plants.
  • Adenylate Kinase
    • Which catalyzes the production of ATP from ADP.
  • Dephospho-COA Kinase
    • Which is actually the DPCK domain of CoAsy, so it uses ATP as phosphate donor in phosphorylation of 3-hydroxy group of ribose in the COA synthesis pathway.
Structural comparison of Dephospho-COA Kinase (IJJV) and Bifunctional coenzyme A synthase from Mus musculus (2F6R) with bound ATP.

Next | Previous

Retrieved from "http://compbio.biosci.uq.edu.au/mediawiki/index.php?title=Coenzyme_A_Synthase%27s_Relation_To_Other_Structurally_Related_Proteins&oldid=5206"