Conclusion (1zkd)

From MDWiki
Jump to navigationJump to search

LOC55471 is a highly conserved non-nuclear Methyltransferase

Taken all results together it can be assumed that the bacterial 1zkd and its mouse and human orthologs might act as methyltransferases in a variety of tissues. The substrate might be s-adenosylmethionine (Fig.18) leaving s-adenosylhomocysteine as a product after transferring the reactive methyl group to a protein or nucleic acid (Fig.17). The lack of nucleus localisation signals (NLS) in the orthologs and the negatively charged surface of 1zkd indicate that this conserved protein might rather act as a modifier of other proteins in the cytoplasm or mitochondria by transferring methyl groups from the substrate S-adenosylmethionine to other proteins. This posttranslational modification could have a variety of impacts on target protein function e.g. in cell signalling. Although it remains unclear how these protein-protein interaction might occur. Another possibility could be that 1izkd and its orthologs are associated with other proteins while performing transmethylation, which might be able to bind nucleic acids like RNA. Thus, it cannot be excluded that the 1zkd and its orthologs might be involved in RNA methylation in the cytoplasm or in mitochondria (Fig.17).


Figure 17. Possible functions of 1zkd and its orthologs in the cytoplasm or mitochondrium. They might transfer reactive methyl-groups to other proteins (X) or might build complexes with other protein (Y) to methylate RNA.



Figure 18. S-Adenosylmethionine (http://en.wikipedia.org/wiki/S-adenosyl_methionine)


Return to Report on 1zkd


[Reference]