DAP Structural Analysis: Difference between revisions

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From here, the results of the conserved regions in the sequence is taken from the evolutionary analysis part. These conserved regions are then marked out in red in the following image below (Fig:X).
From here, the results of the conserved regions in the sequence is taken from the evolutionary analysis part. These conserved regions are then marked out in red in the following image below (Fig:X).
'''Positions of conserved regions'''
    *
20 PFHATAS
    *  *
40 LDERDAWH
    *
56 VTRNDSS
    * ***
82 GAHTDSPCLRV
    ***      ** *  ***
109  YGGALFAPWFDRDLSLAGRVT
    * * *** 
153  PNLNIHLN
    *      *    *      ***
218  DTQSAAVVGLNDEFIAGARLDNLLS
    ** **    *
267 EEVGSCSHCGA
    *  * *  *  *** 
303 RSLLVSADNAHGVHPNYA
    *  * 
334 GPVIKIN
    *
345 YATNSETA
    *        ** * **      *    ***    *** **       
366 QSFVTRSDMGCGSTIGPITASQVGVRTVDIGLPTFAMHSIRELAG

Revision as of 13:18, 4 June 2008

Chain Sequence of 2ijz-A

>gi|119390187|pdb|2IJZ|A Chain A, Crystal Structure Of Aminopeptidase RAELNQGLIDFLKASPTPFHATASLARRLEAAGYRRLDERDAWHTETGGRYYVTRNDSSLIAIRLGRRSP LESGFRLVGAHTDSPCLRVKPNPEIARNGFLQLGVEVYGGALFAPWFDRDLSLAGRVTFRANGKLESRLV DFRKAIAVIPNLNIHLNRAANEGWPINAQNELPPIIAQLAPGEAADFRLLLDEQLLREHGITADVVLDYE LSFYDTQSAAVVGLNDEFIAGARLDNLLSCHAGLEALLNAEGDENCILVCTDHEEVGSCSHCGADGPFLE QVLRRLLPEGDAFSRAIQRSLLVSADNAHGVHPNYADRHDANHGPALNGGPVIKINSNQRYATNSETAGF FRHLCQDSEVPVQSFVTRSDMGCGSTIGPITASQVGVRTVDIGLPTFAMHSIRELAGSHDLAHLVKVLGA FYASSELP


Structural Analysis of 2ijz-A chain

2ijz-A.JPG

Fig x: A) Front view of 2ijz-A chain structure; B) Back view of 2ijz-A –chain Structure; Pictures showing the loops (pink), beta-sheet (magenta) and alpha helix (greenish blue) of the structure taken from PyMOL.

Dali Results.JPG

Fig X: Part of DALI search results gathering structurally related proteins. The three marked proteins in orange were structurally aligned using PyMOL. Proteins 13 to 18 were not taken as no scientific evidence of the protein has been obtained yet.

From here, the results of the conserved regions in the sequence is taken from the evolutionary analysis part. These conserved regions are then marked out in red in the following image below (Fig:X).

Positions of conserved regions

    *

20 PFHATAS

    *   *

40 LDERDAWH

    * 

56 VTRNDSS

    * *** 

82 GAHTDSPCLRV

    ***       ** *  *** 

109 YGGALFAPWFDRDLSLAGRVT

    * * ***  

153 PNLNIHLN

    *       *    *      ***

218 DTQSAAVVGLNDEFIAGARLDNLLS

   ** **    *

267 EEVGSCSHCGA

    *   * *  *   ***  

303 RSLLVSADNAHGVHPNYA

   *   *  

334 GPVIKIN

   *

345 YATNSETA

   *         ** * **      *    ***     *** **        

366 QSFVTRSDMGCGSTIGPITASQVGVRTVDIGLPTFAMHSIRELAG