DHRS1 Conclusion
From MDWiki
Jump to navigationJump to search
BALLS
Through comparison of HSDR1 against protiens with similar structure it was possible to identify several conserved regions that are important in the folding and function of HSDR1.
HSDR1 may reduce Glucose by using NADP as an electron donor. Further kinetic studies with other likely substrates (sugars) are needed to confirm this. An [G-x(3)-G-x-G] motif that is a Characteristic co-enzyme binding fold may bind a substrate possibly glucose. Site directed mutagenasis and futher Kinietic studies will regveal the role of this motif, if any.
