Deduction from Dali and Profunc

From Interpro

Function of isopentenyltransferase = synthesizes isopentenyladensosine 5'-monophosphate

Function of adenylate kinase and guanylate kinase= catalyzes the ATP-dependent phosphorylation of GMP into GDP

Also, -found a P-loop pattern in adenylate kinase and guanylate kinase

-P-loop is said to be involved in ATP/GTP binding

Since there is a fold similarity between adenylate kinase and 2qgn, P-loop might be present.

Adenylate kinase --> P-loop motif is formed between a β-strand and a α-helix, at its N-terminus.

From PDB and Profunc, - ligand interacts with AVGKT at position 775-780 - This is towards the end-terminus of the protein sequence and - This sequence is between a β-strand and a α-helix (PDBsum)

Guanylate kinase has a P-loop as well but different pattern from adenylate kinase. - Divergence of the P-loop motif This accounts for the fact that 2qgn cannot be superimposed onto guanylate kinase