Evolution

Query Sequences (2gfh)

mgsdkihhhh hhmglsrvra vffdldntli dtagasrrgm levikllqsk yhykeeaeii

cdkvqvklsk ecfhpystci tdvrtshwee aiqetkggad nrklaeecyf lwkstrlqhm

iladdvkaml telrkevrll lltngdrqtq rekieacacq syfdaivigg eqkeekpaps

ifyhccdllg vqpgdcvmvg dtletdiqgg lnaglkatvw inksgrvplt sspmphymvs

svlelpallq sidckvsmsv

Multiple Sequence Alignments (msa)

Figure 20. The schematic diagrams of glycolysis and pentose phosphate metabolic pathways. The green arrows show the substrates that are hydrolyzed by HADs (A) Glycolysis pathway with substrates that are hydrolyze by HADs: glucose 6-phosphate, fructose 6-phosphate and dihydroxyacetone phosphate. (B) Pentose phostphate pathway with substrates that are hydrolyze by HADs: glucose-6-phosphate, fructose-6-phosphate, dihydroxyacetone phosphate, glyceraldehyde-3-phosphate, gluconate 6-phosphate and erythrose-4-phosphate.

Table of functions

Catalytic activity	N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate
Cofactor	Magnesium (By similarity)
Enzyme regulation	Inhibited by vanadate and calcium (By similarity)
Pathway	Carbohydrate metabolism; aminosugar metabolism
Similarity	Belongs to the haloacid dehalogenase-like hydrolase superfamily. NANP family

Separate Enzymes Catalyze the Final Two Steps of Coenzyme A Biosynthesis in Brevibacterium ammoniagenes: Purification of Pantetheine Phosphate Adenylyltransferase