Evolution

Query Sequences (2gfh)

Table of functions

mgsdkihhhh hhmglsrvra vffdldntli dtagasrrgm levikllqsk yhykeeaeii cdkvqvklsk ecfhpystci tdvrtshwee aiqetkggad nrklaeecyf lwkstrlqhm iladdvkaml telrkevrll lltngdrqtq rekieacacq syfdaivigg eqkeekpaps ifyhccdllg vqpgdcvmvg dtletdiqgg lnaglkatvw inksgrvplt sspmphymvs svlelpallq sidckvsmsv

Figure 1. Amino Acid Sequence (260 aa) of N-acetylneuraminic Acid (2gfh) protein from Mus musculus (House Mouse)

Multiple Sequence Alignments (msa)

Figure 1. Multiple Sequence Alignments of 2gfh amino acid sequences with that of other similar protein sequences in various organisms (A) Glycolysis pathway with substrates that are hydrolyze by HADs: glucose 6-phosphate, fructose 6-phosphate and dihydroxyacetone phosphate. (B) Pentose phostphate pathway with substrates that are hydrolyze by HADs: glucose-6-phosphate, fructose-6-phosphate, dihydroxyacetone phosphate, glyceraldehyde-3-phosphate, gluconate 6-phosphate and erythrose-4-phosphate.

Table of functions

Catalytic activity	N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate
Cofactor	Magnesium (By similarity)
Enzyme regulation	Inhibited by vanadate and calcium (By similarity)
Pathway	Carbohydrate metabolism; aminosugar metabolism
Similarity	Belongs to the haloacid dehalogenase-like hydrolase superfamily. NANP family

Separate Enzymes Catalyze the Final Two Steps of Coenzyme A Biosynthesis in Brevibacterium ammoniagenes: Purification of Pantetheine Phosphate Adenylyltransferase