Evolution ERp18: Difference between revisions
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This page discusses the evolution of the target protein, ''Endoplasmic reticulum thioredoxin superfamily member''. | This page discusses the evolution of the target protein, ''Endoplasmic reticulum thioredoxin superfamily member''. | ||
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==Methods== | ==Methods== | ||
To generate a collection of sequences which were, apparently, related to the target protein (ERp18), a PSI-Blast search was conducted. PSI-BLAST is advantageous as it uses an iterative approach whereby selected, relavent results from previous searches are used to inform the next search operation. The PSI-BLAST method was particularly useful in this circumstance since ERp18 is part of a superfamily of proteins and so has many homologues which have high identity scores and low e-vaulues but are actually different proteins. | |||
The collected sequences | |||
==Results== | ==Results== | ||
Revision as of 12:37, 15 June 2009
This page discusses the evolution of the target protein, Endoplasmic reticulum thioredoxin superfamily member.
Introduction
importance of evolution
Methods
To generate a collection of sequences which were, apparently, related to the target protein (ERp18), a PSI-Blast search was conducted. PSI-BLAST is advantageous as it uses an iterative approach whereby selected, relavent results from previous searches are used to inform the next search operation. The PSI-BLAST method was particularly useful in this circumstance since ERp18 is part of a superfamily of proteins and so has many homologues which have high identity scores and low e-vaulues but are actually different proteins.
The collected sequences
Results
add other zoomed in trees
Discussion
related to what organisms?
distant from other orgaisms?
important enzyme?
