Evolution ERp18

This page discusses the evolution of the target protein, Endoplasmic reticulum thioredoxin superfamily member.

Introduction

importance of evolution

Methods

To generate a collection of sequences which were, apparently, related to the target protein (ERp18), a PSI-Blast search was conducted. PSI-BLAST is advantageous as it uses an iterative approach whereby selected, relavent results from previous searches are used to inform the next search operation. The PSI-BLAST method was particularly useful in this circumstance since ERp18 is part of a superfamily of proteins and so has many homologues which have high identity scores and low e-vaulues but are actually different proteins.

The collected sequences

Results

add other zoomed in trees

Discussion

related to what organisms?

distant from other orgaisms?

important enzyme?