Function: Difference between revisions

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The predicted function based on the evolution and structure


=='''Proposed Functions'''==
<font size = "4">'''Hydrolase'''</font>


* Hydrolase Activity


* Magnesium Ion Binding
[[Image:Document18_01.png]]


* N-acylneuraminate-9-phosphatase Activity
Hydrolyase catalyze the hydrosis of the chemical bond between A and B, resulting of 2 simple molecules


* Phosphoglycolate Phosphatase Activity


* Hydrolase
** Catalyze hydrolysis reaction 
** Addition of the hydrogen and hydroxyl ions of water
** Splitting into 2 or more simpler molecules
** EC class 3


[http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0016787 1. Hydrolase Activity]


[http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0000287 2. Magnesium Ion Binding]


[http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0050124 3. N-acylneuraminate-9-phosphatase Activity]
== Function of sulfatases ==


[http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0008967 4. Phosphoglycolate Phosphatase Activity]
Sulfatases are enzymes,which hydrolyse sulfate ester bonds of substrates.  
Most of the family members has shown to contain a highly conserved cystine residue and a bivalent metal binding site.






{| border="1" cellpadding="15" cellspacing="0"
|+'''Table of functions'''
|Catalytic activity
|N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate
|-
|Cofactor
|Magnesium (By similarity)
|-
|Enzyme regulation
|Inhibited by vanadate and calcium (By similarity)
|-
|Pathway
|Carbohydrate metabolism; aminosugar metabolism
|-
|Similarity
|Belongs to the haloacid dehalogenase-like hydrolase superfamily. NANP family
|}




== Functional site==
MSA data revealed some conserved residues on the sequence. They were mapped on the three dimantional structure.


 
[[Image:Zn_Cl_surface]]
=='''GO Terms'''==
Polymer: haloacid dehalogenase-like hydrolase domain containing 4
 
Molecular Function: None
 
Biological Process: None
 
Cellular Component: None
 
 
 
 
 
 
----
 
info
 
N-acetylneuraminic acid phosphatase
 
Homologous to mouse (Mus musculus)
 
Haloacid Dehalogenase Like Hydrolase Domain Containing 4
 
Classified as Hydrolase 
 
[http://www.ebi.ac.uk/thornton-srv/databases/profunc/index.html Infomation on ProFunc] (useful 2gfhA)
 
[http://www.ebi.ac.uk/pdbsum/ Information on PDBsum] (2gfh)


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Latest revision as of 09:44, 20 May 2008

The predicted function based on the evolution and structure

Hydrolase


Document18 01.png

Hydrolyase catalyze the hydrosis of the chemical bond between A and B, resulting of 2 simple molecules


  • Hydrolase
    • Catalyze hydrolysis reaction
    • Addition of the hydrogen and hydroxyl ions of water
    • Splitting into 2 or more simpler molecules
    • EC class 3


Function of sulfatases

Sulfatases are enzymes,which hydrolyse sulfate ester bonds of substrates. Most of the family members has shown to contain a highly conserved cystine residue and a bivalent metal binding site.



Functional site

MSA data revealed some conserved residues on the sequence. They were mapped on the three dimantional structure.

File:Zn Cl surface

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