Function for haloacid dehalogenase-like hydrolase domain containing 2: Difference between revisions
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Haloacid dehalogenase-like hydrolase domain containing 2 (2HO4:A,B) | Haloacid dehalogenase-like hydrolase domain containing 2 (2HO4:A,B) | ||
Where's does this name come from? We look at it's name. | Where's does this name come from? We look at it's name. | ||
Hydolase indicates it's main molecular function, [http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0016787 /hydrolase activity] | Hydolase indicates it's main molecular function, [http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&depth=1&query=0016787 /hydrolase activity] | ||
Definition of hydrolase activity: | Definition of hydrolase activity: | ||
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Hydrolase is the systematic name for any enzyme of EC class 3. | Hydrolase is the systematic name for any enzyme of EC class 3. | ||
And, Domain containing 2 illustrate it has 2 domains | And, Domain containing 2 illustrate it has 2 domains | ||
Revision as of 03:00, 5 June 2007
Haloacid dehalogenase-like hydrolase domain containing 2 (2HO4:A,B)
Where's does this name come from? We look at it's name.
Hydolase indicates it's main molecular function, /hydrolase activity
Definition of hydrolase activity:
Catalysis of the hydrolysis of various bonds
e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
Hydrolase is the systematic name for any enzyme of EC class 3.
And, Domain containing 2 illustrate it has 2 domains
/ Sequence and Secondary Structure
From the above diagram, we see 2 domain color in blue and purple showed separately.
Type: polypeptide(L)
Length: 259 residues
Secondary Structure: 44% helical (14 helices; 123 residues) 17% beta sheet (12 strands; 48 residues)
2HO4Aa: pdp domain 2HO4Aa (in purple)
2HO4Ab: pdp domain 2HO4Ab (in blue)
But this does not conclude all it's function
From the Protein Data Bank (PDB) /PBD Biology and Chemistry Report
We found it has 3 Ligands and Prosthetic Groups
ID Name Chemical Formula Weight Ligand PO4 Phosphate Ion O4 P 3- 94.971 MG Magnesium Ion Mg 2+ 24.305 MSE Selenomethionine C5 H11 N O2 Se 196.107
And at Mouse Genome Informatics (MGI) /Gene Ontology Classifications
We found 5 Category of Function or Process with evidence.
Category Classification Term Evidence Molecular Function catalytic activity IEA Molecular Function hydrolase activity IEA Molecular Function hydrolase activity IEA Molecular Function magnesium ion binding IEA Biological Process metabolic process IEA Gene Ontology Evidence Code Abbreviations: IEA = Inferred from electronic annotation
So where's the evidence from?
The evidence was done by Mammalian Orthology Load, which information was derived from Homologene National Center for Biotechnology Information. This polymer was reviewed in 2004 and record with J Number: J:90500.
The Mammalian Orthology Query Results shows the Orthology Evidence were used both Amino acid sequence comparison and NT Nucleotide sequence comparison. With species of human, mouse(laboratory), rat, chimpanzee and dog(domestic) all contain this polymer.
CDS 1..259
/gene="HDHD2"
/coded_by="NM_032124.4:134..913"
/GO_function="hydrolase activity"
/GO_process="metabolism"
/db_xref="CCDS:CCDS32829.1"
/db_xref="GeneID:84064"
/db_xref="HGNC:25364"
/db_xref="HPRD:13640"
GO_function:/ hydrolase activity
GO_process:/ metabolic process
Gene Detail:/ Hdhd2
FASTA of HDHD2 of haloacid dehalogenase-like hydrolase domain containing 2 Homo sapiens
COExpresson of Predict Functional Protein:/ HDHD2 haloacid dehalogenase-like hydrolase domain containing 2
ProFunc Result:/ 2ho4
HDHD2 (259 aa) (Homo sapiens) is highly conservatity to Pan troglodytes, Macaca mulatta, Rattus norvegicus, Mus musculus species.
Predicted Functional Partners: KIAA0423 annotation not available (1723 aa)
/ Gene Ontology Classifications
