Function for haloacid dehalogenase-like hydrolase domain containing 2

Haloacid dehalogenase-like hydrolase domain containing 2 (2HO4:A,B)

Where's does this name come from? We look at it's name.

Hydolase indicates it's main molecular function, /hydrolase activity

Definition of hydrolase activity:

Catalysis of the hydrolysis of various bonds

e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Hydrolase is the systematic name for any enzyme of EC class 3.

And, Domain containing 2 illustrate it has 2 domains / Sequence and Secondary Structure

From the above diagram, we see 2 domains color in blue and purple showed separately.

Type: polypeptide(L)

Length: 259 residues

Secondary Structure: 44% helical (14 helices; 123 residues) 17% beta sheet (12 strands; 48 residues)

2HO4Aa: pdp domain 2HO4Aa (in purple)

2HO4Ab: pdp domain 2HO4Ab (in blue)

But this does not conclude all it's function

From the Protein Data Bank (PDB) /PBD Biology and Chemistry Report

We found it has 3 Ligands and Prosthetic Groups

ID    Name Chemical     Formula          Weight Ligand 
PO4   Phosphate Ion     O4 P 3-          94.971     
MG    Magnesium Ion     Mg 2+            24.305   
MSE   Selenomethionine  C5 H11 N O2 Se   196.107   

/ PO4

/ MG

/ MSE

And at Mouse Genome Informatics (MGI) /Gene Ontology Classifications

We found 5 Category of Function or Process with evidence.

Category             Classification          Term Evidence 
Molecular Function   catalytic activity      IEA 
Molecular Function   hydrolase activity      IEA 
Molecular Function   hydrolase activity      IEA 
Molecular Function   magnesium ion binding   IEA 
Biological Process   metabolic process       IEA 

Gene Ontology Evidence Code Abbreviations:
IEA = Inferred from electronic annotation

So where's the evidence from?

The evidence was done by Mammalian Orthology Load, which information was derived from Homologene National Center for Biotechnology Information. This polymer was reviewed in 2004 and record with J Number: J:90500.

The Mammalian Orthology Query Results shows the Orthology Evidence were used both Amino acid sequence comparison and NT Nucleotide sequence comparison. With species of human, mouse(laboratory), rat, chimpanzee and dog(domestic) all contain this polymer.

/more information

What about it's functional partners

From [STRING /http://string.embl.de/newstring_cgi/show_input_page.pl?UserId=4xCciRro5pgE&sessionId=RXsGUpyd0vPD] uses orthology information from the excellent COG database, we predicted it's functional partners.

From the result of occurrence we discover KIAA0423 annotation, which is still not available (1723 aa) is it best suit predicted Functional Partners. / more information

COExpresson of Predict Functional Protein:/ HDHD2 haloacid dehalogenase-like hydrolase domain containing 2

ProFunc Result:/ 2ho4

HDHD2 (259 aa) (Homo sapiens) is highly conservatity to Pan troglodytes, Macaca mulatta, Rattus norvegicus, Mus musculus species.

Predicted Functional Partners: KIAA0423 annotation not available (1723 aa)

/ ProKnow

/ Gene Ontology Classifications

/ PDB sum

/ Mammalian Orthology Proteins

http://symatlas.gnf.org/SymAtlas/symquery?q=212508