Introduction (1zkd): Difference between revisions
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Protein can be categorised into its structure, function and evolution. Knowing the structure of the protein allows researchers to predict its function and also helps in fighting dieases that proteins are involved. The functions of the protein is important as proteins direct almost all biological functions and by knowing which proteins is responsible for the particular biological functions, drugs can be design to enhance or inhibit the effect it produces. Function will contrains the evolution of the sequence of the express proteins as functional residues are more conserved but function may differ in different organism. | Protein can be categorised into its structure, function and evolution. Knowing the structure of the protein allows researchers to predict its function and also helps in fighting dieases that proteins are involved. The functions of the protein is important as proteins direct almost all biological functions and by knowing which proteins is responsible for the particular biological functions, drugs can be design to enhance or inhibit the effect it produces. Function will contrains the evolution of the sequence of the express proteins as functional residues are more conserved but function may differ in different organism. | ||
There are many methods used to predict structure and function of the protein but evolution methods rely on many related sequences, this is also another reason why protein needs to be identify. Unknown proteins can be used to compared with known proteins for its structure and functions, therefore less time and resource will be used in identifying proteins. | There are many methods used to predict structure and function of the protein but evolution methods rely on many related sequences, this is also another reason why protein needs to be identify. Unknown proteins can be used to compared with known proteins for its structure and functions, therefore less time and resource will be used in identifying proteins. Function prediction is more accurate with the accumulation of evidence from: | ||
1. Sequence by comparing with known proteins | 1. Sequence by comparing with known proteins | ||
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2. Structure - Functions is determined by the structure. The functions might change after duplication or have multiple functions. Therefore combining structural and sequence knowledge helps in determin the functions. | 2. Structure - Functions is determined by the structure. The functions might change after duplication or have multiple functions. Therefore combining structural and sequence knowledge helps in determin the functions. | ||
3. Genomics Context | 3. Genomics Context - Functional units are conserved in bacteria proteins and functionally related proteins get often joint during evolution. | ||
4. Cellular Context | 4. Cellular Context - Cellular and sub-cellular as localisation limits the possible function. | ||
5. Evolutionary Context | 5. Evolutionary Context | ||
Revision as of 05:35, 9 June 2007
Protein Identification
Protein can be categorised into its structure, function and evolution. Knowing the structure of the protein allows researchers to predict its function and also helps in fighting dieases that proteins are involved. The functions of the protein is important as proteins direct almost all biological functions and by knowing which proteins is responsible for the particular biological functions, drugs can be design to enhance or inhibit the effect it produces. Function will contrains the evolution of the sequence of the express proteins as functional residues are more conserved but function may differ in different organism.
There are many methods used to predict structure and function of the protein but evolution methods rely on many related sequences, this is also another reason why protein needs to be identify. Unknown proteins can be used to compared with known proteins for its structure and functions, therefore less time and resource will be used in identifying proteins. Function prediction is more accurate with the accumulation of evidence from:
1. Sequence by comparing with known proteins
2. Structure - Functions is determined by the structure. The functions might change after duplication or have multiple functions. Therefore combining structural and sequence knowledge helps in determin the functions.
3. Genomics Context - Functional units are conserved in bacteria proteins and functionally related proteins get often joint during evolution.
4. Cellular Context - Cellular and sub-cellular as localisation limits the possible function.
5. Evolutionary Context
Sequences
From Mouse
1. mtalvrrcva raglpciwrg kcyssgnepa esnqvtpmlr hlmykikstg pitvaeymke vltnpakgyy vhqdmlgekg dfitspdisq ifgellgvwf vsewiasgks pafqlvelgp grgtltadil rvfsqlgsvl ktcaisihlv evsqklseiq altlaeekvp lerdaeslvy mkgvtksgip vswyrdlkdv pegyslylah effdvlpvhk fqktprgwre vfvdvdpqas dklrfvlapc atpaeafiqr derrehvevc pdagviiqel sqriastgga aliadyghdg tktdtlrgfy ghqlhdvlia pgtadltadv dfsylrrmaq gkvaslgpve qrtflknmgi dvrlkvlldk agepsakqql lggydmlmnp qkmgerfhff allphqrlhg gsqernacqs ktpsssvagf delvwq
From Human
2. msvllrsglg plcavaraai pfiwrgkyfs sgnepaenpv tpmlrhlmyk ikstgpitva eymkevltnp akgyyvyrdm lgekgdfits peisqifgel lgiwfisewm atgkstafql velgpgrgtl vgdilrvftq lgsvlkncdi svhlvevsqk lseiqaltlt kekvplerna gspvymkgvt ksgipiswyr dlhdvpkgys fylaheffdv lpvhkfqktp qgwrevfvdi dpqvsdklrf vlapsatpae afiqhdetrd hvevcpdagv iieelsqria ltggaalvad yghdgtktdt frgfcdhklh dvliapgtad ltadvdfsyl rrmaqgkvas lgpikqhtfl knmgidvrlk vlldksneps vrqqllqgyd mlmnpkkmge rfnffallph qrlqggryqr narqskpfas vvagfselaw q
From Bacteria (Rhodopseudomonas palustris)
3. midqtalate ikrlikaagp xpvwryxelc lghpehgyyv trdplgregd fttspeisqx fgellglwsa svwkaadepq tlrlieigpg rgtxxadalr alrvlpilyq slsvhlvein pvlrqkqqtl lagirnihwh dsfedvpegp avilaneyfd vlpihqaikr etgwhervie igasgelvfg vaadpipgfe allpplarls ppgavfewrp dteilkiasr vrdqggaali idyghlrsdv gdtfqaiash syadplqhpg radltahvdf dalgraaesi garahgpvtq gaflkrlgie tralslxaka tpqvsediag alqrltgegr gaxgsxfkvi gvsdpkietl valsddtdre aerrqgthgl ehhhhhh
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