Main Hypothetical Protein Function Page
Literature review
(Ryu, et al., 2004)
This schematic representation shows a proposed mode of action of the RbsD mutarotase.
The articles findings lead to a proposed role for the His20 residue. It proposes the his20 protonates the O5. This causes the breaking of a bond causing it to form an equilibrium between the furan and pyran forms.
(Ryu, et al., 2004)
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String Analysis
This string analysis shows possible protein - protein interactions. The red protein in the middle represents the target protein and the three surrounding proteins represent interacting proteins.
The larger yellow and green proteins may be releated due to cooccurrence, where as the smaller blue protien may be related due to repeatedly occurring in close proximity to the target protein, however the posible interactions shown in the analysis are inconclusive and unsubstantiated. experimental evidence is needed to prove such relationships
Profunc
Interpro Scan result
This image shows the results of a InterProScan. The InterProScan search identifies sequence motifs from several databases.These results show that the target protein belongs to the RbsD/FucU superfamily (Purple and red lines) The gray line shows an possible binding histadine site.
PDB Sequence Match
This PDB scan compares structure alignment. The highest structural match with our sequence is shown to be involved in an d-ribose high affinity transport system. This supports the theory that our hypothetical protein is involved in the ABC transport system of ribose in prokaryote cells.
Residue Conservation Analysis
In this anaysis the residues are highlighted in different colours representing the levels of conservity. The red residues are the most conserved followed by pink, orange ect.
The yellow residue is highly conserved. acourding to certain literature it is very functionally important in the related ribose_fucu superfamily.
Fold Match
This anaysis compares the similiar folds between structures. This again shows that the same d-ribose high affinity transport from the previous PDB analysis has the highest similarity, thus again reinforces the close relationship of our protein with ribose transport systems in prokaryote bacteria. This suggests similar function.
