Molecular dynamics simulation of thermophile and mesophile ortholog pairs

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Abstract

Thermophilic (high temperature loving) and mesophilic (medium temperature loving) organisms have adapted their live style to survive and thrive in environments of different temperature. This requires that proteins in thermophilic organisms have similar dynamic properties as proteins from mesophilic organisms at lower temperature. Here we will test this hypothesis by performing molecular dynamics simulations of several orthologous proteins from extreme thermophilic, thermophilic and mesophilic organisms.

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--ThomasHuber 08:48, 27 February 2008 (EST)