Protein Evolution

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Conservation of MIF4GD in Eutheria (Placental Mammals)

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=41389


Conservation of the protein structure in many organisms, including Pan troglodytes (chimpanzee), Mus musculus (house mouse), Rattus norvegicus (brown rat), Bos taurus (domestic cow) and Danio rerio (zebrafish).

SUMMARY

The protein sequence was transformed into FASTA format

File:FASTA.txt

Using Command Prompt and the CD, BLASTed the protein sequence. First used a vertebrate_other database (which produced only 12 significant results), before was finally able to access the nonredundant database with 68 homologous matching sequences and several different species including Danio rerio, Homo sapiens, Mus musculus, Bos taurus, Xenopus tropicalis, Rattus norvegicus, Xenopus laevis, Macaca fascicularis (Long-tailed macaque), Canis familiaris, Pan troglodytes, Drosophila melangaster, Drosophila pseudoobscura,