35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNNNNSAAP PEEEATTCCR RTAAAVVPGG LTTARAAMQQ QPTTQQLLLL TVVRRKKAAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYEAAAATTF AAIQQQVLSS SRESGRKTRS SGGLLVVIAA QPPPPQQWAH LPPGKHAVVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AERAEFTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M LGKEEPTAAA ---------- ---------- ---------- ---------- -------LLK SQGCLGQTTT ---------- ---------- ---------- ---------- ---------- ---------- MMGRRSSPPT PPLNNNNRTT THNPAPASPP PRRVVPPTPP RNNNNPPCPP ARHSLVHIII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MKRREF---- ---------- ---------- ---------- ---------- ---------- MKRFIVPSSS ---------- --------MA AAIVPRDPTT TFFFFYPPKM MMMMMPPPEE DAYYYCCLYY ---------- ---------- --MAKPDPTT TFFFFYPPRD DDDDMPPPEE DAYYYAALYY ---------- ---------- ---MSPDPTT TFFFFHAAEL LLLLMPAAEE EAYYYLLLSS ---------- ---------- ---MTPDPTT TFFFFHAAKL LLLLMPAAEE NAYYYLLLSS ---------- ---------- ---MTPDPTT TFFFFYPPKL LLLLMPVVEE KAFFFMMLSS ---------- ---------- --MATPDPSS SFFFFYPPRL LLLLAPPPEE TAYYYMMFDD ---------- ---------- --MVTPDPTT TFFFFYPPRM MMMMVPAAEE KAYYYRRLNN ---------- ---------- --MASPDPTT TFFFFYPPKM MMMMMPRREE RGYYYLLLDD ---------- ------MMTK KKCTKCGPGG GYYYYPTTEA AAAAKPRREE EVYYYCCIYY ---------- ---------- ---------- ---------- ----MPRREE EVYYYCCIYY VVLIAPPARR GLG-AAHHTQ QQCGKCGPGG GYYYYPSSEA AAAAKPRREE EVYYYCCIYY ---------- ---------- ---------- ---------- ----KPRREE EIYYYCCIYY ---------- ------MMTK KKCGNCGPGG GYYYYSTTEA AAAAKPRREE EVYYYCCIYY TTLQSVVAQQ PMIASSTTTK KKCGNCGPGG GYYYYSTTEA AAAAKPRREE EVYYYCCIYY ---------- ------MMTK KKCGNCGPGG GYYYYSTTEA AAAAK----- ---------- ---------- ------MMTK KKCGNCGPGG GYYYYSTTEA AAAAKPRREE EVYYYCCIYY AAQPWFFLSS GQQEDDTTTK KKCGDCGPGG GYYYYPTTEA AAAAKPRREE EVYYYCCIYY TTNTELLHTT YCVFTTSSTK KKCGNCGPGG GYYYYSTTEA AAAAKPRREE EVYYYCCIYY ---------- ------MMTK KKCGNCGPGG GYYYYSTTEA AAAAKPRREE EVYYYCCIYY IIMEGAAAAA VEAAAANNKT TTCCHKGPGG GYYYYATTEA AAAAEPRREE KVYYYCCVYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AK KKCGSCGPGG GYYYYKSSDA AAAAKPRREE EVYYYCCIYY --MATVVLDD HGNEKKKK-V VVNGCSGPGG GYYYYASSES SSSSSPRREE SIYYYAAVYY --MGTVVLQQ HASEKKVVNQ QQQGCSGPGG GYYYYASSEA AAAASPRREE TIYYYAAVYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --RMLGGPGG GYYYYATTAA AAAASPSSEE KIYYYAAVYY ---------- --AAAANNAA AACCGTGPGG GYYYYATTEA AAAAEPRREE KLYYYCCVYY ---------- --SPNNCCLK KKCHG-GPGG GYYYYASSDA AAAAKPRREE ELFFFAAP-- ---------- --P---CCLK KKCHG-GPGG GYYYYASSDA AAAAKPRREE ELFFFAAP-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MS SSESKCGPGG GYYYYATTDA AAAARPVVEE KLYYYCCVQQ ---------- ---------- ---------- ---------- ----RPRREE KLYYYTTVQQ ---------- ---------- ------MPGG GLLLLITTDI IIIIIDDDRR FYFFFWWLHH ---------- ALG-AALLMG GGLPFFADEE ETTTTCQQYM MMMMKGQQEE EVYYYTTLGG SSMHFAALRR ALGLAALLLA AAAPARADEE ETTTTCAAYM MMMMKGQQEE DVYYYTTLGG GTTIINAAAA ADFANNNPPK SEETYSKIVV KVLLLPPINN DDLHHHFNAC CCSSAPPPN- GTTVVNPPPP PDFADDDPPK SPPTYGKVII KLLLLPPIGG DDLHHHFNAC CCSSAPPPN- DFF---PPPP PDAAKKKPPG SSSTYGKIVV TVMMMPPTGG DDFHHHFNAC CCSSSPPPLG DFF---PPPP PDAAKKKPPG SPPTYGQIVV TVMMMPPKGG DDFHHHFNAC CCSSAPPPLG DAA---PPPP PDGADDDPPT SEEKFGQIVV QLMMMPPKGG DDFHHHFNAC CCSSAPPPLG ERR---PPPP PDAADDDPPA SPPRYASIVV QVMMMPPAGG DDLHHHFNAC CCSSCPPPNP MAAGG-PPPP PDACDDDSSQ SSSTFGQVVV VTMMMPPTGG GGLHHHFNAC CCSSMPPPNP GRR---PPPP PDAGDDDPPD SGGTYAQIVV RVMMMPPAAA DDLHHHFNAC CCSAAPPPYP NTTTTEPPPP PDYADDDPPK SPPQYSQVII RLMMMPPLKK DDLHHHSNTC CCSSC----G NTTIIEPPPP PDYADDDPPK SPPHYSQVII RLMMMPPLKK DDLHHHSNTC CCSSC----G NTTIIEPPPP PDYADDDPPK SPPQYCQVII RLMMMPPLRR DDLHHHSNAC CCSSC----G NTTIIEPPPP PDYADDDPPK SPPQYCQVII RLMMMPPLKK DDLHHHSNTC CCSSC----G NTTTTEPPPP PDYADDDPPK SPPQYCQVII RLMMMPPLKK DDLHHHSNTC CCSSC----G NTTTTEPPPP PDYADDDPPK SPPQYCQVII ---------- ---------- ---------- ---TTEPPPP PDYADDDPPK SPPQYCQVII RLMMMPPLKK DDLHHHSNTC CCSSC----G NTTTTEPPPP PDYADDDPPK SPPQYCQVII RLMMMPPLKK DDLHHHSNTC CCSSC----G NTTTTEPPPP PDYADDDPPK SPPQYSQVII RLMMMPPLKK DDLHHHSNTC CCSSC----G NTTTTEPPPP PDYADDDPPK SPPQYCQVII RLMMMPPLKK DDLHHHSNTC CCSSC----G NTTTTEPPPP PDYADDDPPK SPPQYCQVII RLMMMPPLKK DDLHHHSNTC CCSSC----G GTTIINLLLL LDYADDDPPS SPPTYSQVII RLVVVIIIGG DDLHHHSNSC CCSSC----G ---------- ---------- ---------- --MMMPPTNN DDLHHHSNTC CCSSC----G STTIINPPPP PDYADDDPPK SPPSYSQVII RLMMMPPVNN DDLHHHSNTC CCSSC----G GTTIIEPPPP PDYADDDPPS SPPTYSKVII RLVVVPPVGG DDLHHHTNSC CCSSC----G GTTIIEPPPP PDYADDDPPN SPPTYSKVII RLVVVPPVGG DDLHHHTNSC CCSSC----G ---------- ---------- ---------- --MMMPPVGG DDLHHHSNSC CCSSC----G GTTIIDPPPP PDYADDDPPS SPPSYSSVII RLMMMPPVGG DDLHHHSNSC CCSSC----G GTTIINPPPP PDYGDDDPPN SPPTYSQVII RLVVVTTVGG DDLHHHSNAC CCSSC----G -NNAADPPPP PDAFNNNPPE SDDTFCQVII RVVVVPPIGG DDVHHHTNAC CCSSC----D -HHRRDPPPP PDAFNNNPPE SEETFCQIII RVVVVPPIGG DDVHHHTNAC CCSSC----D ---------- ---------- ---------- ---------- ---------- ---------- NLLEEEGGGG GDYADDDPPA SPPTYCQVII RTTTTNNKHH NNLHHHSNTC CCSSCPPP-G NLLEEPGGGG GDYSDDDPPE SPPTYCQIVV RTTTTNNKGG DDLHHHSNAC CCSSCDDDES DIIQQYIIII ITDKVVVGGQ VFFLGGSVLL DGVVVKKLEE DDEDDDSTPR RRILK----G EGGGGDQQQQ QDKVRRRPPG SAATRGQVII SVVVVGG-RR NNAHHHGSA- ---------- EGGGGDQQQQ QDKVNNNPPK SPPQYGKVVV TLVVVGG-RR NNAHHHSTD- ---------- PPNIERFFPP LLSSSSIIDT TPPRPPPIII KEEEEVKKKV SSGRHHHTHC CCPPAAYSSA PPFLERYYPP LLSSSSIVDT TPPRPPPAAA KEEEVAGGGR TTGKHHHTHC CCPPAAYSSA AAFLERFFPP LLSSSSIIDT TPPTAAAHHH KEEEEIAAAK TTGRHHHTHC CCPPGGYSST AAFIERYYPP LLSSSSIIDT TPPTAAAHHH KEEEEVKKKK TTGRHHHTHC CCPPGGYSST AAFLERYYPP IISSSSIVDV V--LAAAHHH KEEEEVAAAK TTGRHHHTHC CCPPGGYSST PPHMERYYPP LLSSSSILDT TPPLPPPAAA KEEETLEEER TTGRHHHTHC CCPPGGYTTA PPHVERYYPP IISSSSILDT TPPTPPPVVV KDDDELEEER TTGRHHHTHC CCPPGGYSSA PPHVERYYPP IISSSSIVDT TPPRPPPVVV KEEEELRRRR TTGRHHHTHC CCPPGGYSSA SSTKSNKKPP LLSSSSIVDV VSSRPPPHHH KEEEEIAAAK CCNNHHHTHC CCAAGGVVVN SSTKSDKKPP IISSSSIVDV VSSRPPPHHH KEEEEIAAAK CCNNHHHTHC CCAAGGVIIS SSTKSTKKPP LLSSSSIVDV VSSRPPPHHH KEEEDIAAAK CCGYHHHTHC CCAAGGVIIS IITKATKKPP LLSSSSIVDV VTTRPPPHHH KEEEDITTTK CCNFHHHTHC CCPPGGVVVS SSTKSTKKPP LLSSSSIVDV VSSRPPPHHH KEEEDIAAAK CCEFHHHTHC CCAAGGVIIS ---------- ---------- ---------- ----DIAAAK CCEFHHHTHC CCAAGGVIIS SSTKSTKKPP LLSSSSIVDV VSSRPPPHHH KEEEDIAAAK CCEFHHHTHC CCAAGGVIIS SSTKSTKKPP LLSSSSIVDV VSSRPPPHHH KEEEDIAAAK CCEFHHHTHC CCAAGGVIIS SSTKSNKKPP FFSSSSIVDV VTTRPPPHHH KEEEDIEEEK CCGTHHHTHC CCPPGGVIIS SSTKSTKKPP LL-------- ---------- ---------- ---------- ---------- SSTKSTKKPP LLSSSSIVDV VSSRPPPHHH KEEEDIAAAK CCEFHHHTHC CCAAGGVIIS PPSAKRFFPP LLSSGGVVDT TTTRPPPHHH KEEEDIEEEN IIGFHHHTHC CCAAGGIIIS AASKVNKKPP LLSSSSIVDV VTTRPPPHHH KEEEEVWWWK CCGNHHHTHC CCGGGGIIIS SSSKVNKKPP LLSSSSIVDV VSSRPPPHHH KEEEEVWWWK CCGNHHHTHC CCGGGGIIIS PPSAERFFPP LLSSGGIIDT TTTRPPPHHH KDDDDIQQQK TTGYHHHTHC CCAAGGLIIS PPSAQRFFPP IISSGGVIDT TTTRPPPHHH KEEEDITTTK TTGYHHHTHC CCAAGGIIIS AASADRYYPP LLSSGGIIDT TEERPPPYYY KDDDEIEEEK TTGYHHHTHC CCAAGGIVVS AASVDRYYPP LLSSGGIIDT TEERPPPYYY KDDDEIDDDK TTGFHHHTHC CCTTGGIVVS PPSASRFFPP LLSSGGVVDT TKKRPPPHHH KEEEDIEEEK TTGFHHHTHC CCAAGGIIIS PPTEKSHHPP LLSSDDIINV VNNRIIIEEE HEEEKLSSSL NN-FHHHTHC CCAAGGIIIS PPTEKSHHPP LLSSDDIINV VNNRIIIQQQ HEEEKLAAAL NN-FHHHTHC CCAAGGIIIS --------RR LLSSGGEVFV VGG------- ---------- ---------- ---------- EEVPTDRRPP LLSSDDIIDT TTTRPPPAAA KEEEDVKKKG AADAHHHTHC CCPPGGIIIS TTVPKDRRPP LLSSDDILDV VTTRPPPVVV KDDDDVKKKS HHNAHHHTHC CCAAGGIIIS RRVQGPQQLL LLGGKKLTTS SYYWKKKYYY P---DLKKKF LLVIHHHTDY YYPPTTLQQD ----DRFFGG LLTTNNIFDV VSSSPPPHHH KDDDFVDDDS GGGGHHHTFA AAPPSSMTTG ----DRYYGG LLTTSSIFDV VSSAPPPSSS KTTTFVKKKS GGGGHHHTYA AAPPRRLTTG ALLLGNN--G GGGPPPPPGI ILLMLDYYSF FFEEPGEIII RDD------- ----DFWN-V ALLLGGG--G GGGPPPPPGI IFFLLDDDTF FFEEPGEVVV RPP------- ----DFWN-V TLLLGGGGKG GGGAAAAAPI IFFIMDEETF FFDDVGEIII RPP------- ----DFWN-Y TLLLGGGGKG GGGPPPPPPV VFFIMDEETF FFEEVGEIII RPP------- ----DFWN-Y TLLLGGGGEG GGGPPPPPPI IFFILDEETF FFEEIGEMMM REE------- ----DFWN-Y ALLLGNN--G GGGPPPPPGI IAAMLDQQSF FFEEPGEVVV RPP------- ----DGWH-T ALLLGSS--G GGGPPPPPGI IFFILDDDNL LLEEVGEIII RDD------- ----DFWH-T ALLLGSS--G GGGPPPPPGV VFFVMDEESF FFDDPGEVVV RPP------- ----DFWH-T NTTTLGG--Q GGGKKKKKGF FVVLLDEETF FFEEVGEKKK GAA------- ----DFYQ-V SSSSLGG--Q GGGKKKKKGF FVVLLDEETF FFEEVGEKKK GEE------- ----DFYQ-I STTTLGG--K GGGKKKKKGF FVVLLDEETF FFEEVGEQQQ GAA------- ----DFYQ-V STTTLGG--E GGGKKKKKGF FVVLLDKKTF FFEEVGEQQQ GAA------- ----DFYQ-V SSSSLGG--K GGGKKKKKGF FVVLLDEETF FFEEVGERRR GAA------- ----DFYQ-V SSSSLGG--K GGGKKKKKGF FVVLLDEETF FFEEVGERRR GAA------- ----DFYQ-V SSSSLGG--K GGGKKKKKGF FVVLLDEETF FFEEVGERRR GAA------- ----DFYQ-V SSSSLGG--K GGGKKKKKGF FVVLLDEETF FFEEVGERRR GAA------- ----DFYQ-V STTTLGG--K GGGKKKKKGF FVVLLDEETF FFEEVGERRR GSS------- ----DFYQ-V ---------- ---------- ---------- ---------- ---------- ---------- SSSSLGG--K GGGKKKKKDS SLLVLL--RL LLEECG---- ---------- ---------- SCCCLGG--E AAAAAAAAGG GFFLLLSSEF FFNNVGSNNN LPP------- ----THYEYL SSSSIGG--Y GGGKKKKKGF FVVLLDEETF FFEEVGEAAA GAA------- ----DFYQ-V SSSSLGG--C GGGKKKKKGF FVVLLDEETF FFEEVGEVVV GSS------- ----DFYQ-V SCCCLGG--D AAAEEEEEGG GFFLLLSSDF FFNNVGEKKK GSS------- ----DFYQ-T SCCCIGG--D AAAEEEEEGG GFFLLLSSEF FFNNVGEKKK GSS------- ----DFYQ-T SCCCLGG--E AAAKKKKKGG GFFLLLSSDF FFNNINEKKK GSS------- ----DFYQ-T SCCCLGG--E AAAKKKKKGG GLLLLLSSDF FFNNINEKKK DSS------- ----HFYQ-T SCCCLGG--E AAAAAAAAGG GFFLLLSSEF FFNNVGEKKK GSS------- ----DYYQ-T STTTLGG--N PPPSSSSSGF FLLLLDKKTF FFEEPGPAAA ETT------- ----DFYQ-V STTTLGG--D PPPSSSSSGF FLLLLDKKTF FFEEPGPAAA GVV------- ----DFYQ-I ---------- ---------- ---------- ---------- ---------- ---------- SIIIMGG--E AAAKKKKKGD DFFVEFKKNF FFEELGSRRR DKK------- ----DYYQ-V SVVVMGG--E AAAKKKKKGD DFFILFSSDF FFNNCGTKKK DKK------- ----DFYQ-V DGGGVNN--L PPPVVVVVLG GIIQTSHHEN NNGGLAEAAA QEE------- ----SNNN-K GLLLSNN--D GGGRRRRRTL LVVEYNDDGE EEYYVTMPPP ADDGAVVAGG AVGGDIAL-V GLLLSNN--D GGGRRRRRTL LVVEYTAAGE EEYYVTIPPP DDDGAIIKGG KYGGDVAL-L VVSWVVPNN- TTIEED--LK EHLL-YGGGG IHHFWWLRRR KRIIHHHHHL TLGGNNNAAA VITWVVPRR- CCFEEE--FS ECLLGYGGGG LHHVWWLARR RHLLYYYYYI DLGGHHHVVV YVSWLLPPP- QQFEEN--IV EDLLNYGGGG LHHFWWLRRR RNVVQQQQQI DLGGHHHAAA YVTWLLPPP- QQFEEN--IV EDLLNYGGGG LHHFWWLRRR RNVVQQQQQI DLGGHHHAAA YVSWLLPPP- QQFEEN--IV EDLLNYGGGG IHHFWWLRRR KNVVQQQQQI DLGGHHHAAA TVTWTTPDD- MMVEED--LV DILLAYGGGG LHHFWWLTRR RHLLQQQQQI DFGGHHHVVV TLTWTTPRR- MMVEES--VL DELLGYGGGG LHHVWWLYRR RHLLQQQQQL DLGGYYYAAA TVTWTTPNN- MMIEEG--LD QILLKYGGGG LHHIWWLRRR RHLLQQQQQL DVGGHHHVVV VVSWAAPNN- VVFKKDFFNP HVEEGYGGGG IFFVWWWQHH EIIIQQQQQL QMTTDDDIII IVSWAAPNN- VVFKKDFFNP HVEEGYGGGG IHHVWWWQHH EIIIQQQQQL QMKKDDDIII VISWAAPNN- VVFRRDFFNP DVEEGYGGGG LHHVWWWQHH EIIIQQQQQL TLQQDDDIII VISWAAPNN- VVLRRDFFNP DVKKGYGGGG LYYVWWWQRR EIVVQQQQQL PLQQDDDIII VISWAAPNN- VVLRRDFFNP DVEEGYGGGG LYYVWWWQHH EIVVQQQQQL SLKKDDDIII VISWAAPNN- VVLRRDFFNP DVEEGYGGGG LYYVWWWQHH EIVVQQQQQL SLKKDDDIII VISWAAPNN- VVLRRDFFNP DVEEGYGGGG LYYVWWWQHH EIVVQQQQQL SLKKDDDIII VISWAAPNN- VVLRRDFFNP DVEEGYGGGG LYYVWWWQHH EIVVQQQQQL SLKKDDDIII VISWAAPNN- VVVQQNFFNP DVEEGYGGGG LHHVWWWQHH EIVVQQQQQL LMPPDDDIII ---------- ---------- ---------- ---------- ---------- ---------- ---SHHSNN- LLRLLTSSRD PASSSVAAAA T--------- ---------- ---------- LWSQCCSLL- FFYTTTAAEL CLTTSVHHHH SCCLDDYIRR VIDDEEEEEL PLQQDDDGGG VISWAAPKK- AAFAALFFKM EVQQGYGGGG LNNVWWWTHH RRIIQQQQQI DLGGDDDIII VISWAAPKK- AAFAALFFKM DVQQGYGGGG LNNVWWWTHH RLVVQQQQQI DLGGDDDIII TISWAAPTT- AAFTTKFFDL HVAAGYGGGG LTTCIILAGG ELRRQQQQQL DLGGTTTLLL TISWAAPKK- AAFLLQFFNL HVAAGYGGGG LHHVYYWPGG EIKKQQQQQL DLGGKKKLLL TISWAAPKK- AAFSSKFFDL HVAAGYGGGG LHHVYYWPGG EMKKQQQQQI DLGGTTTLLL TISWAAPKK- AAFSSKFFNL HVAAGYGGGG LHHVYYWPGG EIKKQQQQQI DLGGTTTLLL TISWAAPAA- AAFRRTFFDL HVQQGYGGGG LHHVYYWPGG ELKKQQQQQL DLGGTTTLLL VISWSSPNN- HHIKKKFFNP HVGGGYGGGG VHHIFFWDKK KYLLQQQQQI DLPPLLLLLL IISWSSPNN- HHIKKKFFNP HVPPGYGGGG VHHIFFWDKK KHLLQQQQQI DLPPRRRLLL --SRGGPVV- TTVCCREEEL CQPPPVIIII KRRVYY---- ---------- ---------- VVAWAAPKK- LLFRRRYYHP DCDDTYGGGG LNNFYYWQRR ELFFQQQQQI DLGGDDDTTT VVSWAAPNN- KKWRRRWWKN DLEESYGGGG LNNFYYWSQQ TLYYQQQQQI DLGGDDDTTT KESPEEPII- MMAFFESSES LKKKPKPPPP VAAEVV---- ---------- ---------- VLTFGGWSSY MMMDDFQQML DAEEKFGGGG IVVQWWLHRR QPKKKKKKKF NVPPPPP--- LVTFGGWNNY MMMDDFKKML DPEEKFGGGG VVVTWWLHKK QPKKKKKKKF DVPPPPP--- LLL-----EE RPPLLLHTMF FINNNVVKKK DDLSIIWYY- EDGGNNAAEK VEEIPEELEG LLL-----EE RPPLLLHTMF FVNNNVLKKK DDLSIIWYY- EDGGQQAAER VDDIEQQFEG LLL-----EE RPPAAAHVYF FVGGGVVTTT NNLGIIWRR- EGGGHHVVKK TTTIPEEATA LLL-----EE RPPAAAHVYF FVGGGVVTTT NNLAIIWRR- EGGGHHAAEK TTTIPEEAPK LLL-----EE RPPAAAHSYF FCGGGVVTTT NNLGIIWQQK DDGGEEAAKK TTTIDVVADA FFF-----EE RPPAAAHTYF FVNNNVIKKK DDLSIIWRR- DKDDAAVVRK VEEIPEEADP LLL-----EE RPPAAAHTYF FMNNNVVKKK DDLAIIWRR- DNGGHHLLKK VDDIPEEASE LLL-----EE RPPAAAHAYF FVGGGVVEEE DDLAVVWRR- QNGGGGIIRK VEEIPEEAEP PPP----LEE RFFLLLHSQF FVGGGALNNN IIQFKKE--- ---------- -WWSVKKIQV PPP----LEE RFFLLLHDQF FVGGGALNNN IIQFKKG--- ---------- -WWSVKKIQV PPP----LEE RFFLLLHDQF FVGGGALTTT IIQFKKG--- ---------- -WWSVKKIQV PPP----LEE RFFLLLHDQF FVGGGALTTT IIQFKKD--- ---------- -WWSAKKIQV PPP----LEE RFFLLLHDQF FVGGGALTTT IIQFKKG--- ---------- -WWSVKKIQV PPP----LEE RFFLLLHDQF FVGGGALTTT IIQFKKG--- ---------- -WWSVKKIQV PPP----LEE RFFLLLHDQF FVGGGALTTT IIQFKKG--- ---------- -WWSVKKIQV PPP----LEE RFFLLLHDQF FVGGGALTTT IIQFKKG--- ---------- -WWSVKKIQV PPP----LEE RFFLLLHAQF FVGGGALTTT IIQFKKG--- ---------- -WWSVKKIEV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAANNNPLCC RSSIIIHNQY YDVVVEVSSS GGRGDDA--- ---------- -VVVLRRLDL PPP----LEE RFFLLLHDQL LVGGGALTTT VVFFKKD--- ---------- -WWAAKKIKV PPP----LEE RFFLLLHDQL LVGGGALSSS IIFFKKD--- ---------- -WWAAKKIQV PPP----LEE RFFLLLHATF FVGGGALNNN MMIFKKD--- ---------- -WWSHLLIPV PPP----LEE RFFLLLHATF FVGGGALNNN MMIFKKD--- ---------- -WWNHIIISV PPP----LEE RFFLLLHSTY YVGGGALNNN MMIFKKD--- ---------- -WWSYIIISV PPP----LEE RFFLLLHSTF FVGGGALNNN MMIFKKD--- ---------- -WWSHVVISV PPP----LEE RFFLLLHSTY YVGGGALNNN MMVFKKD--- ---------- -WWSHVVISI PPP----LEE RFFLLLHTHF FVGGGALGGG IIFIPPESS- ---------T -HHAALLAFI PPP----LEE RFFLLLHTHF FVGGGALAAA IIFIPPKPP- ---------K -QQTALLATI ---------- ---------- ---------- ---------- ---------- ---------- PPP----LEE RFFLLLHRQY YVGGGAFXXX XXXX------ ---------- ---------- PPP----LEE RFFLLLHKEF FVGGGALKKK VVFFKKDDD- ---------E FAAKKIIIPG ---------- ---------- ---------- ---------- ---------- ---------- -------LEE RFFPPPWNYF FSTTTALQQQ LLWIEEA--- ---------- --------EW -------LEE RCCAAAWAYF FTSSSALQQQ LLWIEEE--- ---------- --------EW GGLLLKPFFK KKVVLLVTID ISSLLKFLYL LLSLLGEDDI SSNNPFKKPP GKVVVKKLGR GGLLLKDFFK KKVVLLVTID ISSLLRFLYV VVSLLGEDDI TTNNPHQQPP GRVVVKKIGR AALLLQGFFG GGVVLLVTID LSSLLRFLYV VVSCCGEDDV SSDDPHNNPP GSVVVRRIGR KKLLLQGFFG GGVVLLVTID LSSMMRFLYV VVSCCGEDDV SSDDPRKKPP GSVVVHHIGR AALLLKGFFG GGCCLLVTID LSSLLKYLYV VVACCGEDDV SSDDPMNNPP GKVVVEEIGK PPLLLKGFFK KKVVLLVTID LSSMMRFLYV VVSCCGDDDV SSDDPFEEPP GKVVVRRIGR EELLLKPFFK KKVVLLVTIN LSSVVRFLYV VVSCCGEDDV SSDDPFNNPP GKVVVQQIGR PPLLLKDFFG GGVVLLVTIN LSSLLRFLYV VVSCCGEDDV SSDDPFNNPP GSVVVRRLGK VVKKGWMLLP PPMMLLITIL LSSLLRFLYF FFSNNLDDDI SSNNPQKKPP GQIIIFFLGR VVKKGWMLLP PPMMLLITIL LSSLLRFLYF FFSNNLDDDI SSNNPKKKPP GQIIIFFLGK VVKKGWMLLP PPMMLLITIL LSSLLRFLYF FFSNNLDDDI SSDDPQRRPP GQLLLFFLGK VVKKGWMLLP PPMMLLITIL LSSLLHFLYF FFSNNLDDDV SSDDPQRRPP GQLLLFFLGK VVKKGWLLLP PPMMLLITIL LSSLLRFLYF FFSNNLDDDI SSDDPQRRPP GQLLLFFLGK VVKKGWLLLP PPMMLLITIL LSSLLRFLYF FFSNNLDDDI SSDDPQRRPP ---------- VVKKGWLLLP PPMMLLIT-- ---------- ---------- ---------- ---------- VVKKGWLLLP PPMMLLITIL LSSLLRFLYF FFSNNLDDDI SSDDPQRRPP GQLLLFFLGK VVKKGWMLLP PPMMLLITIL LSSLLRFLYF FFNNNLDDDI SSDDPKRRPP GQIIIFFLGK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLAAKFGVVV VVLLEEFPAW IFFFFLLIIF FFLSS----- ---------- ---------- VVKKGWALLP PPMMLLITIL ISSLLRFLYF FFSNNLDDDI TTDDPRNNPP GQIIIFFLGR VVKKGWPMMP PPMMLLITIL ISSLLRFLYF FFSNNLDDDI TTDDTRNNPP GQIIIFFLGR VVLLNWILLP PPMMLLITFL ISSLLRFLYF FFVNNLDNNI EEDDLKNNPP GQLLLWWVGK VVLLNWFLLP PPMMLLITFL ISSLLRFLYF FFVNNLDNNI EEDDVKNNPP GQVVVWWAGK VVLLNWILLP PPMMLLITFL ISSLLRFLYF FFVNNLDNNI EEDDPKNNPP GQIIIWWVGK VVLLNWILLP PPMMLLITFL ISSLLRFIYF FFVNNLDNNI EEDDPKNNPP GQIIIWWVGK IILLNWILLP PPMMLLITFV ISSLLRYLYL LLVNNLDNNI EEDDPAKKPP GQVVVWWAGK IIKKGWALLP PPMMLLITIL ISSMMRFLYV VVSCCLDDDI SSDDPLKKVV SQVVVYYIGT IIKKNWALLP PPMMLLITIL ISSMMRFLYV VVSCCLDDDI SSDDPKNNPP SQVVVFFIGS ---------- ---------- ---------- ---------- ---------- ---------- ----NGEIIE EEMMMMMTIL ISSLLRYLYF FFSNNRDDDI SSDDRANNPP GQVVVFFLGR GGVVSGVAAE EEMMMMISII ISSLLRFLYV VVNCCRDDDI TTDDPENNPP GQLLLFFLGS ---------- ---------- ---------- ---------- ---------- ---------- WWKKDIGNNP PPDDLLPVIS IAAAAQTLWI IINSSMKDDI SSDDPHKKPP YEKKKVVIR- WWKKDIGEEP PPKKLLPVIS ISSNNSRLWV VVNTTMKDDI SSDDPHHHPP YEKKKTTIA- RADHHHPP-- ---------- ----AGHKKL LTAPQQMLRR RYYVNNNNSS SLLWQFPPPK REPHHHPP-- ---------- ----SGAEEA ATAPQQMIRR RYYINNNNSS SLLWQFPPPR RAPHHHPP-- ---------- ----NGRTTF FAGPQQMVRR RYYWNNNNSS SLLWQFPPPP RTPHHHPP-- ---------- ----NGKAAF FAGPQQMVRR RYYWNNNNSS SLLWQFPPPP KTPHHHPP-- ---------- ----NGKTTF FGGPQQMVRR RYYWNNNNSS SLLWQFPPPG RATHHHPPG- ---------- ---AKNGAAL LNGPQQMVRR RYYFNNNNSS SLLVQFPPPD RAGHHHPP-- ---------- ---ATSAEEL LNGPQQMVRR RYYFNNNNSS SLLWQFPPPK KAAHHHPP-- ---------- ----ASGPPL LNGPQQMVRR RYYFNNNNSS SLLWQFPPPR RGGSSSVVQE -DELLTCQPE PLLVKGKRRI IPGPQQMILL RYYATTTTSS SLLWQF---I KGGSSSVVQE -DELLTCQPE PLLVKGKRRV VPGPQQMILL RYYVTTTTSS SLLWQF---I KGGPPPVVQE -DELLKSQPE PLLVKGKKKV VPGPQQMILL RYYVTTTTSS SLLWQF---I KDGPPPVVQD -DELLDSQPE PLLVKGKQQV VAGPQQMILL RYYVTTTTSS SLLWQF---I KGGPPPVVQE -DELLKSQPE PLLVKGKRRV VAGPQQMILL RYYITTTTSS SLLWQF---I ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KGGPPPVVQE -DELLKSQPE PLLVKGKRRV VAGPQQMILL RYYITTTTSS SLLWQF---I KGGPPPVVQE -DELLKSQPE PLLVKGKRRV VPGPQQMILL RYYVTTTTSS SLLWQF---I ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RGGPPPVVTE -DDLLECQPD PVVVKGKKKV VPGPQQMILL RYYVNNNNSS SLLWQF---I RGGPPPVVTE -DELLECQPD PVVVKGKIII IPGPQQMILL RYYVSSSSSS SLLWQF---L KGSPPPVVAG -EGKKTWQSD VPPIQGQKKL LRGPQQMILL RYYVNNNNSS SLLWQF---V KGSPPPVVVK -DGEETWQSD VPPIQGKKKL LRGPQQMILL RYYVNNNNSS SLLWQF---V KGSPPPVVKG -EGNNSFQFD VPPIKGKSSL LRGPQQMILL RYYANNNNSS SLLWQF---M KGSPPPVVKG -EGNNTFQFE VPPIKGKSSL LRGPQQMILL RYYANNNNSS SLLWSF---M KGSEEEVVVT -EDKKEEQYS VPPVKGHRRL LRGPQQMILL RYYVNNNNSS SLLWQFGGGV TESNNNVVKE -GK----PIE ALLVKGRKKI IEGPQQMLLL RYYVTTTTSS SLLWQF---V SETTTTVVKE -EHDD--EIP ALLVKGRQQI IEGPQQMLLL RYYVTTTTSS SLLWQF---V ---------- ---------- ---------- --GPAAKIVV RYYVNNNNSS SFFWQF---V RDAPPPRRRN -DELLKEAPE PVVLKGRRRL LLGPQQMLLL RYYVSSSSSS SLLWQF---V SDLPPPNNVK EDELLKERPP ARRVKGRRRL LEGPQQMLLL RYYVSSSSSS SLLWQF---V ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MVWW RYYFSSSSSS SLLW------ ---------- ---------- ---------- ------MVWW RYYYSSSSSS SLLW------ MMVVKLLLAA A----PSSGG LLIIDFFFFG ---------A ARHQVSGGSS DSSSYCPP-- MMAAKVVVVV V----PEEGG LLLLEFFFFG ---------A ARHQVWGGST DSSSFCPP-- QQVVLAAAAA A----PDDGG LLLLAYWWFP GGGGG----Y YRHQIEGGST DSSSFCPPSV EEVVMAAAVV V----GNNGG LLLLDYFFFP GGGGG----Y YRHQIEGGST DSSSFCPPSV MMVVMAAAVV V----ENNGG LLLLDFWWFP GGGGG----Y YRHQIEGGST DSSSFCPPSV MMVVKLLLAA A----PNNGG IIFFDFFFWP GGGGG----H HRHQVQGGSS DSSSYCPP-- MMVVKVVVVV V----PDDGG MMFFDFFFFG ---------Q QRHQIQGGSS DSSSYCPP-- IIAAKAAAAA A----PGGGG LLLLDFFFVG GGGGG----L LRHQIEGGSS DSSSYCPPS- GGSSVMMMQQ QDDVTVNNGG LLLLNFLLFG EEEEELGGGA ALHELPGGSS DIIIWI---- GGSSVMMMQQ QDDVTANNGG LLLLNFLLFG EEEEELGGGA ALHELPGGSS DIIIWI---- GGSSVMMMQQ QDDVTVKKGG LLLLNFLLFG EEEEELGGGA ALHELPGGSS DIIIWL---- GGSSVMMMQQ QDDVTVKKGG LLLLNFLLFG EEEEELGGGA ALHELPGGSS DIIIWL---- GGSSVMMMQQ QDDVTVKKGG LLLLNFLLFG EEEEELGGGA ALHELPGGSS DIIIWI---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGSSVMMMQQ QDDVTVKKGG LLLLNFLLFG EEEEELGGGA ALHELPGGSS DIIIWI---- GGSSVMMMQQ QDDVTVKKGG LLLLNFLLFG EEEEELGGGA ALHEIPGGTS DIIIWL---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGSSVMMMQQ QDDVTEKKGG LLLLNFLLFG EEEEEGGGGV VLHELPGGSS DIIIWV---- GGAAVMMMQQ QDDVTKKKGG LLLLNFLLFG EEEEEDGGGV VLHEIPGGTS DIIIWI---- GGSSHIIIQQ QDDVTEKKGG LLIINFFFFG EEEEEDGGGA ALHEMPGGTS DIIIWI---- GGSSHIIIQQ QDDVTENNGG LLIINFFFFG EEEEEDGGGS SLHEMPGGTS DIIIWI---- GGSSHIIIQQ QDDVTEKKGG LLIINFFFFG EEEEEEGGGA ALHEMPGGTS DIIIWI---- GGSSHIIIQQ QDDGTEKKGG LLIINFFFFG EEEEEDGGGS SLHEMPGGTS DIIIWI---- GGSSHMMMQQ QDDVTEKKGG LLIINFFFFG EEEEEEGGGS SLHEMPGGTS DIIIWI---- GGAATMMMQQ QNNIPESSGK MMIINFLLFG IIIIIGGGGY YLHEMPGGTS DIIIWI---- GGAATMMMQQ QDDVPITTGH MMIINFLLFG VVVVVGGGGY YLHEMPGGTS DIIIWI---- GGSSVMMMQQ QDDVTEKKGG LLVVNFLLFG EEEEENGGGC CLHDIPCGTS DIIILA---- GGGGTIIIQQ QDDIVENNGG MMLLNFLLFG EEEEEYGGGG GLHEM----- ---------- GGGGHIIILL LDDVTVNNGG IILLNFLLFA EEEEEYGGGS SLHEMPGGTS DIIIWLNNDA ---------- ---------- ---------- ---------- ---------- ---------- GGKKDDDDQQ QLLKYNWWDG KKLLVFAAFY LLLLLLGGG- -RHIMGSSYS S--------- GGKKDDDDQQ QLLKYYWWDG KKLLKFAAFY EEEEELGGG- -RHQMGARYA GPPPAGGGNR ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QQARRRV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NSAAAKKKKQ EAAPCCRRTT TATTGGGLLL TARRLLDDAM MMQQPRTTTQ QQLLLLTTTT gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPGGSPVVVV VIIIIIKAYE EAWTTVLASP PPRRSSEEKR RKTSPGVEII SSAKKQVVPQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MG GRAPPNRTTP PPHHPPNNLP PASPPRPLTT RLVYYRTINP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------IVV VVPPPPTYPS SKKKMMKKAP ---------- ---------- ---------- -------MAA AAKKKPTYPT TRRRDMRRAP ---------- ---------- ---------- --------MM MMSSSPTHAS SEEELMQQAP ---------- ---------- ---------- --------MM MMTTTPTHAS SKKKLMEEAP ---------- ---------- ---------- --------MM MMTTTPTYPS SKKKLMEEGP ---------- ---------- ---------- -------MAA AATTTPSYPS SRRRLAKKAP ---------- ---------- ---------- -------MVV VVTTTPTYPS SRRRMVKKAP ---------- ---------- ---------- -------MAA AASSSPTYPS SKKKMMQQAP ---------- ---------- ---------- -----MACTT TTKKKPGPTP PEEEAK--GP ---------- ---------- ---------- ---------- ---------- -----M--GP QAQQQWAWPP PPPKAVIAAA PARGGGGLLL LLPPAHSCGG GGKKKPGPSP PEEEAK--GP ---------- ---------- ---------- ---------- ---------- -----K--GP ---------- ---------- ---------- -----MACGG GGNNNPGSTP PEEEAK--GP --------AA EEEAFTQSSS VAQPPPPMMR RRPPSTACGG GGNNNPGSTP PEEEAK--GP ---------- ---------- ---------- -----MACGG GGNNNPGSTP PEEEAK--G- ---------- ---------- ---------- -----MACGG GGNNNPGSTP PEEEAK--GP -------GGG KKKETAPWWW FLSGGGGQQL LLWWDTACGG GGDDDPGPTP PEEEAK--GP -----LLNQQ GGGLQTTEEE LHTYYYYCCT TTLLTSPCGG GGNNNPGSTP PEEEAK--GP ---------- ---------- ---------- -----MACGG GGNNNPGSTP PEEEAK--GP PPPPPCPHRR HHHLHIEGGG AAAVVVVEET TTAAANGCCC CCHHHPGATP PEEEAEKKGP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MCGG GGSSSPGKSP PDDDAK--GP ---------- ------ATTT VLDHHHHGGV VVVVKKSNGG GGCCCPGASP PEEESS--GP ---------- ------GTTT VLQHHHHAAV VVVVKVNQGG GGCCCPGASP PEEEAS--GP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------RMM MMLLLPGATP PAAAAS--GP ---------- ---------- ---------M MMAAANGCCC CCGGGPGATP PEEEAEKKGP ---------- ---------- ---------- --MMNCGCHH HHGGGPGASP PDDDAK--GP ---------- ---------- ---------- --MM-CPCHH HHGGGPGASP PDDDAK--GP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------ESS SSKKKPGATP PDDDARNNGP ---------- ---------- ---------- ---------- ---------- -----RSSGP ---------- ---------- ---------- ---------- -----PGIT- -DDDIISSLD --------KK RRRE------ ---AAAALLA AAAAALALPP PPFFFDECQS SYYYMKIITG --------KK RRRIPSHFFF ALRAAAALLV VVSSALAAPP PPAAADECAS SYYYMKIITG EDLAAAVVVA CCTTGGGIIV VDDDNNNSEY SSKVHVYNEL HHHHHCALLC ----PNNG-- EDIAAAVVVA AAVVGGGVLV VDDDDDDSPY GGKIYLYGEL HHHHHCAYYC ----PNNA-- EEFAAATTTL LLPPSSS-LI IDDDKKKSSY GGKVHVNGEF HHHHHCSLLS ----PLLTGG ENFAAATTTL LLPPSSS-LI IDDDKKKSPY GGQVHVNGEF HHHHHCALLS ----PLLAGG EKLAAATTTL MMPPSSS-LV VDDDDDDSEF GGQVHLNGEF HHHHHCALLS ----PLLTGG ETIAAAVVVA MMPPKKK-IV VDDDDDDSPY AASVGVHGEL HHHHHCCLLC ----PNNAPP EKLAAAVVVV RRPPNNNGMV VDDDDDDSSF GGQVGTYGEL HHHHHCMLLC ----PNNAPP ERLGGGVVVA LLPPEEE-LL LDDDDDDSGY AAQVGVNAEL HHHHHCALLC ----PYYAPP EEIVVVLLLP CCRRGGGTLV VDDDDDDSPY SSQIHLYKEL HHHHHCC--- -------FGG EEIVVVLLLP CCRRGGGILV VDDDDDDSPY SSQIHLHKEL HHHHHCC--- -------FGG EEIVVVLLLP CCGGGGGILV VDDDDDDSPY CCQIHLNREL HHHHHCC--- -------FGG EEIIIILLLP CCRRGGGILV VDDDDDDSPY CCQIHLHKEL HHHHHCC--- -------YGG EEIVVVLLLP CCRRGGGTLV VDDDDDDSPY CCQIHLNKEL HHHHHCC--- -------FGG EEIVVVLLLP CCRRGGGTLV VDDDDDDSPY CCQIE----- ---------- ---------- ---------- -------TLV VDDDDDDSPY CCQIHLNKEL HHHHHCC--- -------FGG EEIVVVLLLP CCRRGGGTLV VDDDDDDSPY CCQIHLNKEL HHHHHCC--- -------FGG EEIVVVLLLP CCRRGGGTLV VDDDDDDSPY SSQIHLYKEL HHHHHCC--- -------FGG EEIVVVLLLP CCRRGGGTLV VDDDDDDSPY CCQIHLNKEL HHHHHCC--- -------FGG EEIVVVLLLP CCRRGGGTLV VDDDDDDSPY CCQIHLNKEL HHHHHCC--- -------FGG EKLVVVVVVT CCNNGGGILV VDDDDDDSPY SSQIHLHGKL HHHHHCC--- -------HGG ---------- ---------- ---------- ------NNEL HHHHHCC--- -------YGG EEIVVVLLLP CCRRGGGILV VDDDDDDSPY SSQIHLNNEL HHHHHCC--- -------YGG ESLIIIVVVT AAAAGGGILV VDDDDDDSPY SSKIHLYGEL HHHHHCC--- -------HGG ETLIIIVVVT AAAAGGGILV VDDDDDDSPY SSKIHLYGEL HHHHHCC--- -------HGG ---------- ---------- ---------- ------FGEL HHHHHCC--- -------HGG EKLIIIVVVT AATTGGGILV VDDDDDDSPY SSSIHLFGEL HHHHHCC--- -------HGG EKLLLLVVVT CCNNGGGILV VDDDDDDSPY SSQIHLHGEL HHHHHCC--- -------HGG EEVLLLVVVT AA--AAAAIV VDDDNNNSDF CCQISVHGEV HHHHHCC--- -------HDD EEVLLLVVVT AA--AAARIV VNNNNNNSEF CCQISVNGEV HHHHHCC--- -------HDD ---------- ---------- ---------- ---------- ---------- ---------- EKLLLLVVVV CCPPDDDELV VDDDDDDSPY CCQIHTSHEL HHHHHCCHHF VVVVP--GGG EKLLLLTTTV TTPPDDDELV VDDDDDDSPY CCQVHTRGEL HHHHHCCYYY VVVVDEESSS RFLYYYSSSN WWGGRRRQRP PRRRVVVVFG GGSLKGVEKE LLLDDRK--- --------GG EEFVVVVVVW TTVVMMMGLI IDDDRRRSAR GGQINVGREA HHHHH----- ---------- EDYVVVVVVW TTAAVVVGLV VDDDNNNSPY GGKVNLGREA HHHHH----- ---------- -KKIEFFLPL LLRRRSSSSR IYIIIIIDDT PPPEPKIIKV VVVIEEEEKV SYSRLHCCPD -KKLEYYLPL LLRRRSSSSR IYIIVVVDDT PPKRPAVAKI IIIVEEVVVR TYTKYHCCPD GHHLEFFLPL LLRRRSSSSR IYVVIIIDDT PPPQARIHKI IIIIEDEELK TYSRPHCCPE GHHIEYYLPL LLRRRSSSSR IYIIIIIDDT PPPKAKIHKI IIIIEEEEFK TYSRPHCCPD GHHLEYYLPI IIRRRSSSSR IYIIVVVDDV --PKAKIHKI IIIIEEEEFK TYSRPHCCPE PHHMEYYLPL LLRRRSSSSR IYIILLLDDT PPPKPFLAKV VVVIEETTAR TYSRPHCCPG PHHVEYYLPI IIRRRSSSSH ITIILLLDDT PPPQPKVVKV VVVIDNEEAR TYARPHCCPD PHHVEYYLPI IIRRRSSSSR IHIIVVVDDT PPPEPRIVKV VVVIEEEEHR TYSRPHCCPD GDDKSKKLPL LLMMMSSSSR IYVVVVVDDV SSPAPKLHKV VVVIESEEQK CVSNTHCCAS GDDKSKKLPI IIIIISSSSR IYVVVVVDDV SSPAPKLHKV VVVIENEEHK CLGNLHCCAS GDDKSKKLPL LLMMMSSSSR IYVVVVVDDV SSPAPKLHKV VVVIEEDDHK CLGYVHCCAS GDDKAKKLPL LLIIISSSSR IYVVVVVDDV TTPAPKLHKV VVVIEKDDHK CLGFFHCCPS GDDKSKKLPL LLIIISSSSR IYVVVVVDDV SSPAPKLHKV VVVIEEDDHK CLAFLHCCAS ---------- ---------- ---------- ---------- -----KDDHK CLAFLHCCAS GDDKSKKLPL LLIIISSSSR IYVVVVVDDV SSPAPKLHKV VVVIEKDDHK CLAFLHCCAS GDDKSKKLPL LLIIISSSSR IYVVVVVDDV SSPAPKLHKV VVVIEKDDHK CLAFLHCCAS GDDKSKKLPF FFIIISSSSR IYVVVVVDDV TTPAPKLHKV VVVIEKDDHK CLGTPHCCPT GDDKSKKLPL LL-------- ---------- ---------- ---------- ---------- GDDKSKKLPL LLIIISSSSR IYVVVVVDDV SSPAPKLHKV VVVIEKDDHK CLAFLHCCAS GDDAKFFLPL LLLLLSSGGR VYVVVVVDDT TTPTPSLHKV VVVVEEDDAN ILGFPHCCAS GDDKVKKLPL LLIIISSSSR IYVVVVVDDV TTPAPRIHKT TTTVEYEEFK CLANLHCCGC GDDKVKKLPL LLIIISSSSR IYVVVVVDDV SSPAPRIHKT TTTVEYEEFK CLANPHCCGC GDDAEFFLPL LLVVVSSGGR IYVVIIIDDT TTPSPSLHKV VVVVDADDIK TLAYPHCCAS GDDAQFFLPI IIVVVSSGGR VYVVIIIDDT TTPAPSLHKV VVVVEEDDSK TLAYPHCCAS GDDADYYLPL LLIIISSGGR IYAAIIIDDT EEPAPSLYKY YYYVDKEEAK TLAYPHCCAS GDDVDYYLPL LLIIISSGGR IYAAIIIDDT EEPAPSLYKY YYYVDKEEAK TLAFPHCCT- GDDASFFLPL LLLLLSSGGR VYVVVVVDDT KKPAPALHKV VVVVEEDDAK TLGFPHCCAS DKKEKHHLPL LLNNNSSDDR IYIIIIINNV NN-KIYLEHT TTTIESKKHL NLSFPHCCAD DKKEKHHLPL LLNNNSSDDR IYVVIIINNV NN-EIYLQHT TTTIESKKHL NLSFPHCCAD -------MRL LLSSSSSGGV EGKKVVVFFV GG-------- ---------- ---------- GKKPTRRLPL LLNNNSSDDR IFVVIIIDDT TTPAPKLAKV VVVIE-DDLG ACTAPHCCPN SKKPKRRLPL LLNNNSSDDF IYIILLLDDV TTPKPEIVKT TTTID-DDLS HVTAPHCCAN GKKQGQQMLL LLDDDGGKKR LYVVTTTTTS YYADKQFYP- ------DDIF LLAISDYYPN ----DFFFGL LLDDDTTNNR IFIIFFFDDV SSPNPKLHKT TTTID-FFKS GVVGPFAAPG ----DYYLGL LLDDDTTSSK IFVVFFFDDV SSPRPVLSKT TTTIT-FFES GVVGPYAAPG DAIYYYYAAA GNE-EG--GG GLHHHSFFEE PLLGGEIDGD DDYY------ -YDFWWPLLV DAIYYYYAAA GGP-DGRRGG GFHHHTFFEE PIIGGEVYGP PPYY------ -YDFWWPMMI EGIYYYYTTT GGAKDGTTGG GFCCCTFFDD VLLGGEIDGP PPDD------ -YDFWWPMMV DGIYYYYTTT GGGKDGTTGG GFCCCTFFEE VLLGGEIDGP PPTT------ -YDFWWPMMV EGIYYYYTTT GGGEDGTTGG GFCCCTFFEE ILLGGEMDGE EETT------ -YDFWWPMMV GGIYYYYAAA GNA-EG--GG GAAAASFFEE PLLGGEVEGP PPYY------ -YDGWWGLLV DGIYYYYAAA GSP-EG--GG GFHHHNLLEE VLLGGEIDGD DDYY------ -YDFWWGLLL DGVYYYYAAA GSP-EG--GG GFHHHSFFDD PLLGGEVEGP PPQQ------ -YDFWWGMMV SGEVVVVNNN LGD-LQGGGG SVGGGTFFEE VKKGGEKPGA AAPP------ -YDFWYRMMV SGEVVVVSSS LGD-PQGGGG GVGGGTFFEE VKKGGEKPGE EEPP------ -YDFWYRMMV SGEVVVVSSS LGD-SKGGGG GVGGGTFFEE VKKGGEQPGA AAPP------ -YDFWYRMMI SGEVVVVSSS LGD-PEGGGG GVGGGTFFEE VKKGGEQPGA AAPP------ -YDFWYRMMI SGEVVVVSSS LGD-VKGGGG GVGGGTFFEE VKKGGERPGA AAPP------ -YDFWYRMMI SGEVVVVSSS LGD-VKGGGG GVGGGTFFEE VKKGGERPGA AAPP------ -YDFWYRMMI SGEVVVVSSS LGD-VKGGGG GVGGGTFFEE VKKGGERPGA AAPP------ -YDFWYRMMI SGEVVVVSSS LGD-VKGGGG GVGGGTFFEE VKKGGERPGA AAPP------ -YDFWYRMMI TGEVVVVSSS LGD-PKGGGG GVGGGTFFEE VKKGGERPGS SSPP------ -YDFWYRMMI ---------- ---------- ---------- ---------- ---------- ---------- SGEVVVVSSS LGD-VKGGGG GLPPPRLLEE CSSGG----- ---------- ---------- SGDIIIISSS LGD-KEGGAA NFDDDEFFNN VKKGGSNRFP PPSS------ -RTHLYAFFW CGEIIIISSS IGD-PYGGGG GVGGGTFFEE VKKGGEAEEA AAPP------ -YDFWYRMMI CGEIIIISSS LGD-PCGGGG GVGGGTFFEE VKKGGEVEES SSQQ------ -YDFWYRMMI SGELLLLSSS LGD-KDGGAA NFDDDDFFNN VKKGGEKPHS SSLL------ -YDFWYRMMI SGEIIIISSS IGD-KDGGAA NFDDDEFFNN VKKGGEKPHS SSLL------ -YDFWYRMMI SGEIIIISSS LGD-EEGGAA NFDDDDFFNN IKKNNEKPHS SSLL------ -YDFWYRMMI -GEIIIISSS LGD-EEGGAA NLDDDDFFNN IKKNNEKPIS SSLL------ -YHFWYRMMI SGEIIIISSS LGD-KEGGAA NFDDDEFFNN VKKGGEKPHS SSLL------ -YDYWYRMMI DGNIIIISSS LGE-ANGGPP NLGGGTFFEE PKKGGPADKT TTPP------ -YDFWYRMMI DGNIIIISSS LGE-ADGGPP NLGGGTFFEE PKKGGPADKV VVPP------ -YDFWYRMMI ---------- ---------- ---------- ---------- ---------- ---------- NGNIIIISSS MGD-AEGGAA -FDDDNFFEE LVVGGSRGRK KKLL------ -YDYWYHMMV NGNIIIISSS MGD-AEGGAA -FDDDDFFNN CIIGGTKGKK KKLL------ -YDFWYYMMV NTALLLLDDD VNE-SLSSPP NIKKKENNGG LSSAAEASFE EEII------ -LSNHN-SSE GSMMMMMGGG SND-DDHHGG AVDDDGEEYY VAATTMPTDD DDQQVDAVAD DYDIRARMML GRMLLLLGGG SNN-KDHHGG AVNNNGEEYY VAATTIPTGD DDRRT-KYAD DYDVRARLLV EEWAAVPPNN N--TIIEGG- --LDDRGGNR IHHFDDLLLK KKIHHSLTGG EENNNRRMAA EEWTTVPPRR R--CFFEGG- --FEEAGGNK LHHVDDLLLK KRLYYAIDGG QQHHHRRMVV EEWAALPPPP P--QFFEGG- --IAAKGGHR LHHFDDLLLA ARVQQTIDGG AAHHHQQMAA EEWAALPPPP P--QFFEGG- --ISSKGGHR LHHFDDLLLA ARVQQTIDGG AAHHHQQMAA EEWGGLPPPP P--QFFEGG- --ISSKGGHK IHHFKKLLLD DKVQQTIDGG AAHHHQQMAA EEWGGTPPDD D--MVVEGG- --LGGRGGRR LHHFDDLLLR RRLQQEIDGG DDHHHQQLVV EEWGGTPPRR R--MVVEGG- --VAAKGGHR LHHVDDLLLR RRLQQTLDGG AAYYYQQMAA EEWGGTPPNN N--MIIEGG- --LNNGGGRR LHHIDDLLLR RRLQQALDGG EEHHHQQMVV EEWAAAPPNN N--VFFKGGF FFN--LGGSR IFFVDDWWWR REIQQTLQTT --DDDGGLII EEWAAAPPNN N--VFFKGGF FFN--LGGSH IHHVDDWWWR REIQQTLQKK --DDDGGLII EEWAAAPPNN N--VFFRGGF FFN--LGGSH LHHVDDWWWR REIQQTLTQQ --DDDGGLII EEWAAAPPNN N--VLLRGGF FFN--LGGSH LYYVDDWWWR REVQQTLPQQ --DDDGGLII EEWAAAPPNN N--VLLRGGF FFN--LGGSH LYYVDDWWWH HEVQQTLSKK --DDDGGLII EEWAAAPPNN N--VLLRGGF FFN--LGGSH LYYVDDWWWR REVQQTLSKK --DDDGGLII EEWAAAPPNN N--VLLRGGF FFN--LGGSH LYYVDDWWWR REVQQTLSKK --DDDGGLII EEWAAAPPNN N--VLLRGGF FFN--LGGSH LYYVDDWWWR REVQQTLSKK --DDDGGLII EEWAAAPPNN N--VVVQGGF FFN--LGGKH LHHVDDWWWR REVQQTLLPP --DDDGGHII ---------- ---------- ---------- ---------- ---------- ---------- IISAAHSSNN N--LRRLGGS SSR--RAAGI T--------- ---------- ---------- IIQCCCSSLL L--FYYTGGA AAE--GHHVI SCCLNNYYYM MVDEESLPQQ --DDDQQAGG EEWGGAPPKK K--AFFAGGF FFK--MGGHS LNNVDDWWWE ERIQQTIDGG EEDDDGGLII EEWGGAPPKK K--AFFAGGF FFK--HGGHS LNNVDDWWWE ERVQQTIDGG KKDDDGGLII SSWGGAPPTT T--AFFTGGF FFD--LGGRH LTTCQQLLLR RERQQTLDGG NNTTTGGLLL SSWGGAPPKK K--AFFLGGF FFN--LGGRH LHHVSSWWWG GEKQQTLDGG DDKKKGGLLL SSWGGAPPKK K--AFFSGGF FFD--LGGSH LHHVSSWWWG GEKQQLIDGG EETTTGGLLL SSWGGAPPKK K--AFFSGGF FFN--LGGSH LHHVSSWWWG GEKQQLIDGG PPTTTGGLLL SSWGGAPPAA A--AFFRGGF FFD--LGGRH LHHVDDWWWG GEKQQTLDGG SSTTTGGLLL EEWGGSPPNN N--HIIKGGF FFN--LGGNS VHHIEEWWWS SKLQQTIDPP QQLLLGGALL EEWGGSPPNN N--HIIKGGF FFN--LGGNS VHHIEEWWWT TKLQQTIDPP MMRRRGGALL LLRGGGPPVV V--TVVCDDE EEE--LIIKC KRRV------ ---------- ---------- EEWGGAPPKK K--LFFRGGY YYHRRQGGCR LNNFRRWWWE EEFQQTIDGG DDDDDGGLTT EEWGGAPPNN N--KWWRGGW WWKMMQGGCR LNNFKKWWWT TTYQQTIDGG SSDDDGGITT RRPDDEPPII I--MAAFSSS SSEGGLPPQH VAAELL---- ---------- ---------- SSFTTGWWSS SNYMMMDGGQ QQMMMRGGNT IVVQDDLLLT TQKKKVFNPP GGPPP----- SSFTTGWWNN NNYMMMDGGK KKMMMHGGNT VVVTDDLLLT TQKKKVFDPP GGPPP----- ---------E ELLLRPPDTG FFIINMVVVV LLDLLLSSSW WY-EEEDGKA AKIIEIAAEP ---------E EVVVRPPDTG FFVVNVVVVL TTDLLLSSSW WY-EEEDGKA ARIIDIAAQP ---------E EVVVRPPDVG FFVVGVVVVV TTNLLLEGSW WR-EEEGGKV VKAATIAAEP ---------E EVVVRPPDVG FFVVGVVVVV TTNLLLEASW WR-EEEGGKA AKAATIPPEP ---------E EIIIRPPDSG FFCCGVVVVV TTNLLLQGAF FQKDDDDGTA AKIITIPPVP ---------E ELLLRPPDTG FFVVNCVVVI LLDLLLSSSW WR-DDDKDKV VKIIEIAAEA ---------E ELLLRPPDTG FFMMNCVVVV LLDLLLSASW WR-DDDNGSL LKIIDIAAEP ---------E ELLLRPPDAG FFVVGVVVVV LLDLLLSASW WR-QQQNGSI IKIIEIAAEP --------LE EIIIRFFDSG FFVVGCAAAL SSIQQQRFYN N--------- --TTWSEEKV --------LE EIIIRFFDDG FFVVGCAAAL SSIQQQRFYN N--------- --TTWSEEKV --------LE EIIIRFFNDG FFVVGCAAAL SSIQQQRFYN N--------- --TTWSEEKV --------LE EIIIRFFNDG FFVVGCAAAL SSIQQQRFFN N--------- --TTWSQQKV --------LE EIIIRFFNDG FFVVGCAAAL SSIQQQRFYN N--------- --TTWSEEKV --------LE EIIIRFFNDG FFVVGCAAAL SSIQQQRFYN N--------- --TTWSEEKV --------LE EIIIRFFNDG FFVVGCAAAL SSIQQQRFYN N--------- --TTWSEEKV --------LE EIIIRFFNDG FFVVGCAAAL SSIQQQRFYN N--------- --TTWSEEKV --------LE EIIIRFFDAG FFVVGCAAAL SSIQQQRFYN N--------- --TTWSEEKV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NNNNNNIILC CLLLRSSWND YYDDVVEEEV FFGRRRGGSP P--------- --AAVVKKRK --------LE EIIIRFFDDG LLVVGCAAAL SSVFFFRFYE E--------- --KKWAEEKV --------LE EIIIRFFNDG LLVVGCAAAL SSIFFFRFYE E--------- --KKWAEEKV --------LE EIIIRFFDAG FFVVGSAAAL SSMIIIRFFT T--------- --SSWSEELA --------LE EIIIRFFDAG FFVVGSAAAL SSMIIIRFFT T--------- --SSWNEEIV --------LE EIIIRFFDSG YYVVGSAAAL SSMIIIRFFN N--------- --TTWSEEIV --------LE EIIIRFFDSG FFVVGSAAAL SSMIIIRFFN N--------- --TTWSEEVV --------LE EVVVRFFDSG YYVVGCAAAL SSMVVVRFFT T--------- --SSWSEEVA --------LE EVVVRFFETA FFVVGCAAAL SSIFFFRIHV VS-------- -TTTHATTLV --------LE EVVVRFFETA FFVVGCAAAL SSIFFFRIHD DP-------- -KVVQTSSLV ---------- ---------- ---------- ---------- ---------- ---------- --------LE EIIIRFFNRG YYVVGCAAAF XXXXXXXXX- ---------- ---------- --------LE EIIIRFFNKG FFVVGCAAAL AAVFFFHFKK KD-------- -EEEAKVVID ---------- ---------- ---------- ---------- ---------- ---------- --------LE EIIIRFFGNA FFSSTTAAAL SSLWWWLIYD D--------- ---------- --------LE EIIIRCCGAC FFTTSTAAAL SSLWWWLIYD D--------- ---------- LLEEEGG--N NPPVVVVPPV VVDDDDDDDK KKLYSWGGGG ERQQIPPFPV VLGVKLLGGH FFEEEGG--P PPPVVVVPPV VVDDDDDDDR RRLYSWGGGG ERQQIPPHPR RLGVKIIGGH AATTTAADDE EPPVVVVPPV VVDDDDDDDR RRLYSWGGGG ERQQVPPHPV VLGVRIIGGR AAPPPKKEEK KPPVVVVPPV VVDDDDDDDR RRLYSWGGGG ERQQVPPRPK KLGVHIIGGR AADDDAADDD DPPCCCCPPV VVDDDDDDDK KKLYAWGGGG EHQQVPPMPV VLGVEIIGGK AADDDPPDDQ QPPVVVVPPV VVDDDDDDDR RRLYSWGGGG DLQQVPPFPK KLGVRIIGGS AASSSEEDDQ QPPVVVVPPV VVDNDDDDDR RRLYSWGGGG EHQQVPPFPR RLGVQIIGGR AAEEEPPDDQ QPPVVVVPPV VVDNDDDDDR RRLYSWGGGG ERQQVPPFPR RHGVRLLGGR IIQQQVVPPS SKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQIPPQPR RLGIFLLGGV IIQQQVVPPS SKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQIPPKPR RLGIFLLGGV IIQQQVVPPP PKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQIPPQPR RLGLFLLGGV IIQQQVVPPP PKKMMMMPPI IIDLDDDDDH HHLYSWLGGG DRQQVPPQPR RLGLFLLGGV IIQQQVVPPP PKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQIPPQPR RLGLFLLGGV IIQQQVVPPP PKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQIPPQPR RL-------- IIQQQVVPPP PKKMMMMPPI II-------- ---------- ---------- ---------- IIQQQVVPPP PKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQIPPQPR RLGLFLLGGV IIEEEVVPPP PKKMMMMPPI IIDLDDDDDR RRLYNWLGGG DRQQIPPKPR RLGIFLLGGV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLDDDLLYYY YVVLLLLSSF FFPWSSSDDL LLIIL----- ---------- ---------- IIKKKVVPPS SKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQIPPRPK KLGIFLLGGL IIQQQVVPPS SKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQITTRPK KLGIFLLGGQ IIPPPVVKKP PKKMMMMPPI IIDLDDDDDR RRLYVWLGGG DRQQILLKPV VLGLWVVGGQ IISSSVVEEP PKKMMMMPPI IIDLDDDDDR RRLYVWLGGG DRQQIVVKPK KLGVWAAGGQ IISSSVVKKP PKKMMMMPPI IIDLDDDDDR RRLYVWLGGG DRQQIPPKPV VLGIWVVGGQ IISSSVVKKP PKKMMMMPPI IIDLDDDDDR RRIYVWLGGG DRQQIPPKPV VLGIWVVGGQ IISSSIIKKP PKKMMMMPPI IIDVDDDDDR RRLYVWLGGG DRQQIPPAPV VLGVWAAGGQ AAFFFIIPPS SKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQIPPLVK KLSVYIIGGH AATTTIIPPS SKKMMMMPPI IIDLDDDDDR RRLYSWLGGG DRQQIPPKPK KLSVFIIGGH ---------- ---------- ---------- ---------- ---------- ---------- ---------- -QQMMMMGGM MMDLDDDDDR RRLYSWRGGG DRQQIRRAPR RLGVFLLGGQ IIPPPGGKKL LDDMMMMGGI IIDIDDDDDR RRLYNWRGGG DRQQIPPEPK KLGLFLLGGC ---------- ---------- ---------- ---------- ---------- ---------- --EEEWWQQA AAADDDDIIP PPDSDDDDDQ QQLWNFMGGG KRLLIPPHPF FQYKVIIRRN --EEEWWQQA AAAKKKKVVP PPDSDDDDDS SSLWNFMGGG KRLLIPPHPR RQYKTIIAAN RAP------- ---------- ---AGHLLMM LLIRDDGGRR RRVVYVNNLL YYSTTTWWWD REP------- ---------- ---SGAAAMM IIVRDDGGRR RRVVYINNLL YYSSSSWWWN RAP------- ---------- ---NGRFFMM VVIRDDGGRR RRVVYWNNLL YYSTTTWWWD RTP------- ---------- ---NGKFFMM VVIRDDGGRR RRVVYWNNLL YYSTTTWWWD KTP------- ---------- ---NGKFFMM VVIRDDGGKR RRVVYWNNLL YYSTTTWWWD RAP------- ---------- -AAKNGLLMM VVIRDDGGRR RRVVYFNNLL YYGAAAVVVD RAP------- ---------- -AATSALLMM VVIRDDGGRR RRVVYFNNLL YYRAAAWWWD KAP------- ---------- ---ASGLLMM VVVRDDGGRR RRVVYFNNLL YYASSSWWWD RGVVVVLE-D DQQQETCCPE PVVKGKIIMM IILLDDGGKR RRLLYATTLL YYSDDDWWWD KGVVVVLE-D DQQQETCCPE PVVKGKVVMM IILLDDGGKR RRLLYVTTLL YYSAAAWWWD KGVVVVLE-D DQQQEKSSPE PVVKGKVVMM IILLDDGGKR RRLLYVTTLL YYSAAAWWWD KDVVVVLD-D DQQQEDSSPE PVVKGKVVMM IILLDDGGKR RRLLYVTTLL YYSAAAWWWD KGVVVVLE-D DQQQEKSSPE PVVKGKVVMM IILLDDGGKR RRLLYITTLL YYSAAAWWWD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KGVVVVLE-D DEEEEKSSPE PVVKGKVVMM IILLDDGGKR RRLLYITTLL YYSAAAWWWD KGVVVVLE-D DQQQEKSSPE PVVKGKVVMM IILLDDGGKR RRIIYVTTLL YYSDDDWWWD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RGVVVVLE-D DKKKDECCPD PVVKGKVVMM IILLDDGGKR RRLLYVNNLL YYSKKKWWWD RGVVVVLE-D DKKKEECCPD PVVKGKIIMM IILLDDGGKR RRIIYVSSLL YYSIIIWWWD KGVAAAIG-E EDDDGTWWSD VIIQGQLLMM IILLDDGGKR RRLLYVNNLL FFSAAAWWWD KGVAAAVK-D DDDDGTWWSD VIIQGKLLMM IILLDDGGKR RRLLYVNNLL FFSAAAWWWD KGVAAAVG-E EDDDGSFFFD VIIKGKLLMM IILLDDGGKR RRLLYANNLL FFSAAAWWWD KGVAAAVG-E EDDDGTFFFE VIIKGKLLMM IILLDDGGKR RRLLYANNLL FFSAAAWWWV KGVYYYVT-E EDDDDEEEYS VVVKGHLLMM IILLDDGGKR RRIIYVNNLL FFSRRRWWWD TEVVVVLE-G GEEEK---IE AVVKGRIIMM LLLLDDGGKR RRLLYVTTLL YYKKKKWWWD SEVVVVLE-E EDDDH---IP AVVKGRIIMM LLLLDDGGKR RRLLYVTTLL YYKKKKWWWD ---------- ---------- --------KK IILVDDGGKR RRLLYVNNFF YYSTTTWWWD RDRVVVLN-D DPPPEKEEPE PLLKGRLLMM LLLLDDGGRR RRLLYVSSLL FFSPPPWWWD SDNIIIVKED DKKKEKEEPP AVVKGRLLMM LLLLDDGGKR RRLLYVSSLL YYSPPPWWWD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM VVQWDDGGKR RRVVYFSSLL LLANNNWWWD ---------- ---------- --------MM VVSWDDGGQR RRLLYYSSLL LLANNNWWWD DDNYYPLGMV VKN-PGGEIF FFVVFFGEE- ---ARRRSHQ QQVVRLGASS DSYCYY---- NNNYYPLGMA AKN-PGGELF FFVVFFGRR- ---ARRRAHQ QQVVRLGAST DSFCYY---- DDDYYPVAQV VLG-PGGTLY YYVVFFPDDG ---YRRRAHQ QQIIRLGCST DSFCYYSVKK DDDYYPVGEV VMG-GGGELY YYVVFFPDDG ---YRRRAHQ QQIIRLGCST DSFCYYSV-- DDEYYPRAMV VMG-EGGTLF FFVVFFPAAG ---YRRRSHQ QQIIRLGCST DSFCYYSV-- DDPYYPIGMV VKG-PGGEFF FFLLWWPKKG ---HRRRPHQ QQVVRLGCSS DSYCYY---- DDEYYPIGMV VKN-PGGQFF FFVVFFGEE- ---QRRRVHQ QQIIRLGASS DSYCFF---- DDEYYPIGIA AKD-PGGSLF FFTTVVGDDG ---LRRRPHQ QQIIRLGSSS DSYCYYS--- DDKYY-LRGS SVVVVGGKLF FFVVFFGKKE LGPALLLAHE EELLRYGCSS DIWI------ DDKYY-LRGS SVIVAGGKLF FFVVFFGKKE LGPALLLAHE EELLRYGCSS DIWI------ DDKYY-LRGS SVIVVGGKLF FFVVFFGKKE LGPALLLAHE EELLRYGCSS DIWL------ DDKYY-LRGS SVIVVGGTLF FFVVFFGKKE LGPALLLAHE EELLRYGCSS DIWL------ DDKYY-LRGS SVVVVGGKLF FFVVFFGKKE LGPALLLAHE EELLRYGCSS DIWI------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDKYY-LRGS SVVVVGGKLF FFVVFFGKKE LGPALLLAHE EELLRYGCSS DIWI------ DDKYY-LRGS SVIVVGGKLF FFVVFFGKKE LGPALLLAHE EEIIRYGCTS DIWL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDKYY-MKGS SVIVEGGKLF FFVVFFGKKE GGPVLLLAHE EELLRYGCSS DIWV------ DDKYY-LKGA AVIVKGGKLF FFVVFFGKKE DGPVLLLAHE EEIIRYGCTS DIWI------ DDKYY-LEGS SHIVEGGKIF FFVVFFGAAE DGPALLLAHE EEMMRYGCTS DIWI------ DDKYY-LEGS SHIVEGGKIF FFVVFFGAAE DGPSLLLAHE EEMMRYGCTS DIWI------ DDRYY-LDGS SHIVEGGSIF FFVVFFGDDE EGPALLLAHE EEMMRYGCTS DIWI------ VVVYY-IEGS SHIGEGGTIF FFVVFFGDDE DGPSLLLAHE EEMMRYGCTS DIWI------ DDEYYGLKGS SHIVEGGSIF FFVVFFGAAE EGPSLLLAHE EEMMRYGCTS DIWI------ DDDYY-HKGA ATVIEGKEIF FFIIFFGKKI GGPYLLLAHE EEMMRYGCTS DIWI------ DDDYY-NRGA ATIVIGHVIF FFIIFFGKKV GGPYLLLAHE EEMMRYGCTS DIWI------ DDKYY-VKGS SVIVEGGTVF FFVVFFGKKE NGPCLLLAHD DDIIRFCSTS DILA------ DDKYY-MAGG GTLIEGGKLF FFVVFFGGGE YGPGLLLPHE EEMMR----- ---------- DDKYY-MSGG GHIVVGGSLF FFVVFFANNE YGPSLLLPHE EEMMRYGCTS DIWLAADA-- ---------- ---------- ---------- ---------- ---------- ---------- DD-----KGK KDYKNDGELF FFVVFFYEEL LG--RRRAHI IIMMRFSLYS S--------- DD-----KGK KDFKYDGELF FFIIFFYAAE LG--RRRPHQ QQMMRFALYA GPAGDDNRLL ------- ------- RR----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- VVQQQAR 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNSAKAAKKE ATRTTAAPTT TGAAAADGAA MMSLRTLSLL PGSSRIIKAY QEEEAATTTT gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------M AGGGSSPPPP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FSSSAIIQVL LASSSRESKG RKKTRRSSVV GGLVEAAAKV VSQAAAVVVQ WAAHWLPKKH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------AAAE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MGLGEEP ---------- ---------- ---------- ---------- ---------- LLLKNSQLLG ---------- ---------- ---------- ---------- ---------- ---------- TPPPPLLNNR RTPPTHNPLA PAASPPPPHH RRVPLVPPYT IVPPRRLLLP CPPPHARLLV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MKEEF ---------- ---------- ---------- ---------- ---------- -----MKIIV ---------- -------MAI FKRDDPPTYY PKKAMAPPPD DDDDAAAYVA CYTGTTIAAA ---------- ---------M LKPDDPPTYY PRRAMAPPPD DDDDAAAYVA AYVGTTLAAA ---------- ---------- MRPDDPPTHH AEEAMAPAAE EEEEAAAYTL LSPDFFLAAA ---------- ---------- MRPDDPPTHH AKKAMAPAAN NNNNAAAYTL LSPDFFLAAA ---------- ---------- LRPDDPPTYY PKKAMGPVVK KKKKAAAFTL MSPDAALAAA ---------- ---------M WKPDDPPSYY PRRAAAPPPT TTTTAAAYVA MDPERRIAAA ---------- ---------M WRPDDPPTYY PRRAVAPAAK KKKKAAAYVV RNPMAAMCCC ---------- ---------M WRPDDPPTYY PKKAMAPRRR RRRRGGGYVA LDPGRRLGGG ---------- -----MATKC --CGGPPGPP TEEMKGPRRE EEEEVVVYLP CYRNTTLAAA ---------- ---------- ---------- ----MGPRRE EEEEVVVYLP CYRNTTLAAA GGALIAAPAA ALLPGHSTQC --CGGPPGPP SEEMKGPRRE EEEEVVVYLP CYGNTTLAAA ---------- ---------- ---------- ---MKGPRRE EEEEIIIYLP CYRNTTLAAA ---------- -----MATKC --CGGPPGSS TEEMKGPRRE EEEEVVVYLP CYRNTTLAAA GGALQSSVAA ARRPITATKC --CGGPPGSS TEEMKGPRRE EEEEVVVYLP CYRNTTLAAA ---------- -----MATKC --CGGPPGSS TEEMKG---- ---------- ------LAAA ---------- -----MATKC --CGGPPGSS TEEMKGPRRE EEEEVVVYLP CYRNTTLAAA GGHQPWWFLL LLLWQTATKC --CGGPPGPP TEEMKGPRRE EEEEVVVYLP CYRNTTLAAA FFDNTEELHH HTTLVSPTKC --CGGPPGSS TEEMKGPRRE EEEEVVVYLP CYRNTTLAAA ---------- -----MATKC --CGGPPGSS TEEMKGPRRE EEEEVVVYLP CYRNTTLAAA LLQMEGGAAA ATTAANGKTC TAKGGPPGAA TEEMEGPRRK KKKKVVVYVT CYNGTTLAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MAKC --CGGPPGKK SDDMKGPRRE EEEEVVVYLP CYRSTTLAAA ---MATTVLL LVVVNKS-VN CKSGGPPGAA SEEMSGPRRS SSSSIIIYVT AYAGTTLAAA ---MGTTVLL LVVVSVNNQQ CKSGGPPGAA SEEMSGPRRT TTTTIIIYVT AYAGTTLAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R QVGGGPPGAA TAAMSGPSSK KKKKIIIYVT AYTGTTLAAA ---------- -MMAANGAAC GATGGPPGAA TEEMEGPRRK KKKKLLLYVT CYNGTTLGGG ---------- ---MSCGLKC ---GGPPGAA SDDIKGPRRE EEEELLLFVT A---NNIFFF ---------- ---MPCPLKC ---GGPPGAA SDDIKGPRRE EEEELLLFVT A---HHIFFF ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MSE CKCGGPPGAA TDDVRGPVVK KKKKLLLYVV CQPNLLLAAA ---------- ---------- ---------- ---MRGPRRK KKKKLLLYTV TQPNLLLSSS ---------- ---------- ---MMPPGII TDDLILDDDF FFFFYYYFSN WHGDIIRKKK GG-------- -AAAGLAMGL RAFAADDECC QYYPKTGQQE EEEEVVVYVW TGVEGGLVVV SSGMHFFALL LVVSGLALAA GVRAADDECC AYYKKTGQQD DDDDVVVYVW TGAEGGLVVV VVDDDVNPPK KSTTYYYSII VVHKPPYIIN LHHGWWNAAA ASSSLCCC-- G--KPNIEEF VVDDDVDPPK KSTTYYYGVV IIYKPPYIIG LHHGWWNAAA ASSSYCCC-- A--KPFLEEY VVDDDVKPPG GSTTYYYGII VVHTPPNTTG FHHGWWNAAA ASSSLSSS-- TGGHAFLEEF VVDDDVKPPG GSTTYYYGII VVHTPPNKKG FHHGWWNAAA ASSSLSSS-- AGGHAFIEEY VVDDDVDPPT TSKKFFFGII VVHQPPNKKG FHHGWWNAAA ASSSLSSS-- TGGHAFLEEY VVDDDVDPPA ASRRYYYAII VVGQPPHAAG LHHGWWNAAA ASSSLCCC-- APPHPHMEEY VVDDDVDSSQ QSTTFFFGVV VVGVPPYTTG LHHGWWNAAA ASSSLCCC-- APPHPHVEEY VVDDDLDPPD DSTTYYYAII VVGRPPNAAA LHHGWWNAAA ASSALCCC-- APPHPHVEEY TTDDDVDPPK KSQQYYYSVV IIHRPPYLLK LHHGWWNTTT TSSS------ FGGDSTKSSK TTDDDVDPPK KSHHYYYSVV IIHRPPHLLK LHHGWWNTTT TSSS------ FGGDSTKSSK TTDDDIDPPK KSQQYYYCVV IIHRPPNLLR LHHGWWNAAA ASSS------ FGGDSTKSSK TTDDDVDPPK KSQQYYYCVV IIHRPPHLLK LHHGWWNTTT TSSS------ YGGDITKAAK TTDDDVDPPK KSQQYYYCVV IIHRPPNLLK LHHGWWNTTT TSSS------ FGGDSTKSSK TTDDDVDPPK KSQQYYYCVV IIE------- ---------- ---------- ---------- TTDDDVDPPK KSQQYYYCVV IIHRPPNLLK LHHGWWNTTT TSSS------ FGGDSTKSSK TTDDDVDPPK KSQQYYYCVV IIHRPPNLLK LHHGWWNTTT TSSS------ FGGDSTKSSK TTDDDVDPPK KSQQYYYSVV IIHRPPYLLK LHHGWWNTTT TSSS------ FGGDSTKSSK TTDDDVDPPK KSQQYYYCVV IIHRPPNLLK LHHGWWNTTT TSSS------ FGGDSTKSSK TTDDDVDPPK KSQQYYYCVV IIHRPPNLLK LHHGWWNTTT TSSS------ FGGDSTKSSK TTDDDLDPPS SSTTYYYSVV IIHRIIHIIG LHHGWWNSSS SSSS------ HGGDPSAKKF ---------- ---------- ----PPNTTN LHHGWWNTTT TSSS------ YGGDASKVVK TTDDDVDPPK KSSSYYYSVV IIHRPPNVVN LHHGWWNTTT TSSS------ YGGDSSKVVK TTDDDVDPPS SSTTYYYSVV IIHRPPYVVG LHHGWWNSSS SSSS------ HGGDPSAEEF TTDDDLDPPN NSTTYYYSVV IIHRPPYVVG LHHGWWNSSS SSSS------ HGGDPSAQQF ---------- ---------- ----PPFVVG LHHGWWNSSS SSSS------ HGGDASADDY TTDDDVDPPS SSSSYYYSVV IIHRPPFVVG LHHGWWNSSS SSSS------ HGGDASVDDY TTDDDVDPPN NSTTYYYSVV IIHRTTHVVG LHHGWWNAAA ASSS------ HGGDPSASSF TTDDDVNPPE ESTTFFFCVV IISRPPHIIG VHHGWWNAAA ASSS------ HDDKPTEKKH TTNNNVNPPE ESTTFFFCII IISRPPNIIG VHHGWWNAAA ASSS------ HDDKPTEKKH ---------- ---------- ---------- ---------- ---------- ---------- TTDDDVDPPA ASTTYYYCVV IIHRNNSKKH LHHGWWNTTT TSSSHFFFVV GGGKEVPTTR TTDDDVDPPE ESTTYYYCII VVHRNNRKKG LHHGWWNAAA ASSSYYYYVV SSSKTVPKKR NNRRRMVGGQ QVLLGGGGVV LLKDKKVLLE ELDQPPTPPP PIIL------ -GGKRVQGGQ TTDDDLRPPG GSTTRRRGVV IINSGGG--R AHHGFFSAAA A--------- -------DDF TTDDDANPPK KSQQYYYGVV VVNTGGG--R AHHDFFTDDD D--------- -------DDY IIVPGLLRRS RIDDKPNPKK IIVVEEEVKK VSSRLTTVVC DDAIYYYISS LNNNNE-EEE IIVPALLRRS RIDDKPDPAA AAIIEEVAGG RTTKYTTVVC DDAIYYYISS LGGGGP-DDD IIIPGLLRRS RIDDKPHARR HHIIEDEIAA KTSRPTTVVC EEGIYYYVSS LGGGGAGDDD IIIPGLLRRS RIDDKPDAKK HHIIEEEVKK KTSRPTTIIC DDGIYYYVSS LGGGGGGDDD IIIPGIIRRS RIDDK-EAKK HHIIEEEVAA KTSRPTTIIC EEGIYYYVSS LGGGGGGDDD VVVPGLLRRS RIDDKPDPFF AAVVEETLEE RTSRPTTVVC GGGIYYYVTT LNNNNA-EEE VVVPDIIRRS HIDDKPDPKK VVVVDNELEE RTARPTTVVC DDGIYYYISS LSSSSP-EEE IIVPGIIRRS RIDDKPDPRR VVVVEEELRR RTSRPTTIIC DDGVYYYVSS LSSSSP-EEE IILPGLLMMS RIDDGSEPKK HHVVESEIAA KCSNTTTSSC SSGEVVVMVV TGGGGD-LLL IILPSIIIIS RIDDGSEPKK HHVVENEIAA KCGNLTTSSC SSGEVVVMII SGGGGD-PPP MMLPCLLMMS RIDDGSDPKK HHVVEEDIAA KCGYVTTSSC SSGEVVVMII TGGGGD-SSS VVLPALLIIS RIDDGTEPKK HHVVEKDITT KCGFFTTSSC SSGEVVVMVV TGGGGD-PPP VVLPSLLIIS RIDDGSEPKK HHVVEEDIAA KCAFLTTSSC SSGEVVVMII SGGGGD-VVV ---------- ---------- -----KDIAA KCAFLTTSSC SSGEVVVMII SGGGGD-VVV VVLPSLLIIS RIDDGSEPKK HHVVEKDIAA KCAFLTTSSC SSGEVVVMII SGGGGD-VVV VVLPSLLIIS RIDDGSEPKK HHVVEKDIAA KCAFLTTSSC SSGEVVVMII SGGGGD-VVV VVLPSFFIIS RIDDGTEPKK HHVVEKDIEE KCGTPTTSSC TTGEVVVMII TGGGGD-PPP VVLPSLL--- ---------- ---------- ---------- ---------- ---------- VVLPSLLIIS RIDDGSEPKK HHVVEKDIAA KCAFLTTSSC SSGEVVVMII SGGGGD-VVV IILPSLLLLS RVDDATDPSS HHVVEEDIEE NIGFPTTSSC SSGDIIIMII CGGGGD-KKK IILPCLLIIS RIDDGTDPRR HHTTEYEVWW KCANLTTSSC CCGEIIIMII SGGGGD-PPP IILPCLLIIS RIDDGSDPRR HHTTEYEVWW KCANPTTSSC CCGEIIIMII SGGGGD-PPP IIAPSLLVVS RIDDKTNPSS HHVVDADIQQ KTAYPTTSSC SSGELLLMII CGGGGD-KKK IIVPGIIVVS RVDDKTNPSS HHVVEEDITT KTAYPTTSSC SSGEIIIMII CGGGGD-KKK VVLPSLLIIS RIDDKENPSS YYYYDKEIEE KTAYPTTAAC SSGEIIILVV CGGGGD-EEE VVLPSLLIIS RIDDKENPSS YYYYDKEIDD KTAFPTTAAC --GEIIILVV CGGGGD-EEE IILPSLLLLS RVDDLKDPAA HHVVEEDIEE KTGFPTTSSC SSGEIIIMII CGGGGD-KKK IIVPCLLNNS RINNENEIYY EETTESKLSS LNSFPTTSSC DDGNIIIMII TGGGGE-AAA IIVPCLLNNS RINNENEIYY QQTTESKLAA LNSFPTTSSC DDGNIIIMII TGGGGE-AAA VVPRKLLSSS VEFFGG---- ---------- ---------- ---------- ---------- VVLPCLLNNS RIDDGTDPKK AAVVE-DVKK GATAPTTTTC NNGNIIIMII IGGGGD-AAA VVLPSLLNNS FIDDVTDPEE VVTTD-DVKK SHTAPTTTTC NNGNIIIMII VGGGGD-AAA LLQLSLLDDG RLTTLYSKQQ YY----DLKK FLAISTTAAY NNTALLLKQQ GNNNNE-SSS WWTGGLLDDT RIDDHSDPKK HHTTD-FVDD SGVGPTTFFA GGSMMMMITT LNNNND-DDD WWAGGLLDDT KIDDHSDPVV SSTTT-FVKK SGVGPTTLLA GGRMLLLITT LNNNNN-KKK GGGG-PILML LDHYYPPPLG WEEERGGGDD Y--------- -------AAY YDDWWWNLLP GGGGRPIFLL LDHDDPPPIG WEEERGGGPP Y--------- -------AAY YDDWWWNLLP GGGGTAIFIM MDCEEVVVLG WEEERGGGPP D--------- -------HHY YDDWWWNLLP GGGGTPVFIM MDCEEVVVLG WEEERGGGPP T--------- -------HHY YDDWWWNLLP GGGGTPIFIL LDCEEIIILG YEEERGGGEE T--------- -------HHY YDDWWWNLLP GGGG-PIAML LDAQQPPPLG WEEERGGGPP Y--------- -------AAY YDDWWWHLLG GGGG-PIFIL LDHDDVVVLG WEEERGGGDD Y--------- -------HHY YDDWWWHLLG GGGG-PVFVM MDHEEPPPLG WEEERGGGPP Q--------- -------AAY YDDWWWHLLG QQQQGKFVLL LDGEEVVVKG WEEEGGGGAA P--------- -------GGY YDDWWYQPPR QQQQGKFVLL LDGEEVVVKG WEEEGGGGEE P--------- -------GGY YDDWWYQPPR KKKKGKFVLL LDGEEVVVKG WEEEGGGGAA P--------- -------GGY YDDWWYQPPR EEEEGKFVLL LDGKKVVVKG WEEEGGGGAA P--------- -------GGY YDDWWYQPPR KKKKGKFVLL LDGEEVVVKG WEEEGGGGAA P--------- -------GGY YDDWWYQPPR KKKKGKFVLL LDGEEVVVKG WEEEGGGGAA P--------- -------GGY YDDWWYQPPR KKKKGKFVLL LDGEEVVVKG WEEEGGGGAA P--------- -------GGY YDDWWYQPPR KKKKGKFVLL LDGEEVVVKG WEEEGGGGAA P--------- -------GGY YDDWWYQPPR KKKKGKFVLL LDGEEVVVKG WEEEGGGGSS P--------- -------GGY YDDWWYQPPR ---------- ---------- ---------- ---------- ---------- ---------- KKKKGKSLVL LLP--CCCSG ---------- ---------- ---------- ---------- EEEEGAGFLL LLDSSVVVKG GSSSLFFFPP S--------- -------EER RTTLLYENNA YYYYGKFVLL LDGEEVVVKG WEEEGEEEAA P--------- -------GGY YDDWWYQPPR CCCCGKFVLL LDGEEVVVKG WEEEGEEESS Q--------- -------GGY YDDWWYQPPR DDDDGEGFLL LLDSSVVVKG WEEEGHHHSS L--------- -------GGY YDDWWYQPPR DDDDGEGFLL LLDSSVVVKG WEEEGHHHSS L--------- -------GGY YDDWWYQPPR EEEEGKGFLL LLDSSIIIKN WEEEGHHHSS L--------- -------GGY YDDWWYQPPR EEEEGKGLLL LLDSSIIIKN WEEEDIIISS L--------- -------GGY YHHWWYQPPR EEEEGAGFLL LLDSSVVVKG WEEEGHHHSS L--------- -------GGY YDDWWYQPPR NNNNGSFLLL LDGKKPPPKG WPPPEKKKTT P--------- -------NNY YDDWWYQPPR DDDDGSFLLL LDGKKPPPKG WPPPGKKKVV P--------- -------NNY YDDWWYQPPR ---------- ---------- ---------- ---------- ---------- ---------- EEEEGKDFVE EFDKKLLLVG WSSSDRRRKK L--------- -------GGY YDDWWYQPPH EEEEGKDFIL LFDSSCCCIG WTTTDKKKKK L--------- -------GGY YDDWWYQPPY LLLLSVGIQT TSKHHLLLSA GEEEQFFFEE I--------- -------QQL LSSHHNNGG- DDDDHRLVEY YNDDDVVVAT WMMMADDDDD QAAVVAAVGG GDVAADGGGY YDDRRALIIR DDDDHRLVEY YTNAAVVVAT WIIIDGGGDD RAAIIKKTGG G-YAADGDDY YDDRRALPPR NEELSWWAVN N-TIDDG--L KLLLLKK--- GGRIHHFDDR RRKKKRHSSS GNRR------ SGGMTWWTVR R-CFEEG--F SLLLLKKGGG GGKLHHVDDA AAKRRHYAAA GHRR------ RDDMSWWALP P-QFNNG--I VPPLLLLNNN GGRLHHFDDR RRARRNQTTT GHQQ------ RDDMTWWALP P-QFNNG--I VPPLLLLNNN GGRLHHFDDR RRARRNQTTT GHQQ------ RDDMSWWGLP P-QFNNG--I VPPLLLLNNN GGKIHHFKKR RRDKKNQTTT GHQQ------ YDDLTWWGTD D-MVDDG--L VPPLLLLAAA GGRLHHFDDT TTRRRHQEEE GHQQ------ YDDLTWWGTR R-MVSSG--V LGGLLLLGGG GGRLHHVDDY YYRRRHQTTT GYQQ------ YDDMTWWGTN N-MIGGG--L DPPLLLLKKK GGRLHHIDDR RRRRRHQAAA GHQQ------ HNNMSWWAAN N-VFDDGFFN PAAEEAAGGG GGRIFFVDDQ QQREEIQTTT TDGG-----L HNNMSWWAAN N-VFDDGFFN PAAEEAAGGG GGHIHHVDDQ QQREEIQTTT KDGG-----L HNNMSWWAAN N-VFDDGFFN PAAEEAAGGG GGHLHHVDDQ QQREEIQTTT QDGG-----L HNNMSWWAAN N-VLDDGFFN PAAKKAAGGG GGHLYYVDDQ QQREEIQTTT QDGG-----L HNNMSWWAAN N-VLDDGFFN PAAEEAAGGG GGHLYYVDDQ QQHEEIQTTT KDGG-----L HNNMSWWAAN N-VLDDGFFN PAAEEAAGGG GGHLYYVDDQ QQREEIQTTT KDGG-----L HNNMSWWAAN N-VLDDGFFN PAAEEAAGGG GGHLYYVDDQ QQREEIQTTT KDGG-----L HNNMSWWAAN N-VLDDGFFN PAAEEAAGGG GGHLYYVDDQ QQREEIQTTT KDGG-----L HNNMSWWAAN N-VVNNGFFN PAAEEAAGGG GGHLHHVDDQ QQREEIQTTT PDGG-----L ---------- ---------- ---------- ---------- ---------- ---------- -----SSAHN N-LRTTGSSR DYYSSAASSS AAIT------ ---------- ---------- WGGFSQQCCL L-FYTTGAAE LMMTTAASSS HHISCCLNNI IIMVVIESSS QDQQNNPPPL HNNMSWWGAK K-AFLLGFFK MEEQQAAGGG GGSLNNVDDT TTERRRQTTT GDGG-----L HNNMSWWGAK K-AFLLGFFK MEEQQAAGGG GGSLNNVDDT TTERRLQTTT GDGG-----L HNNMSWWGAT T-AFKKGFFD LQQAADDGGG GGHLTTCQQA AAREELQTTT GTGG-----L HNNMSWWGAK K-AFQQGFFN LQQAADDGGG GGHLHHVSSP PPGEEIQTTT GKGG-----L HKKMSWWGAK K-AFKKGFFD LQQAADDGGG GGHLHHVSSP PPGEEMQLLL GTGG-----L HKKMSWWGAK K-AFKKGFFN LQQAADDGGG GGHLHHVSSP PPGEEIQLLL GTGG-----L HKKMSWWGAA A-AFTTGFFD LQQQQDDGGG GGHLHHVDDP PPGEELQTTT GTGG-----L RNNMSWWGSN N-HIKKGFFN PAAGGEEGGG GGSVHHIEED DDSKKYQTTT PLGG-----L RNNMSWWGSN N-HIKKGFFN PAAPPEEGGG GGSVHHIEED DDTKKHQTTT PRGG-----L ----SRRGGV V-TVRRDEEE LKKPPEEPPP IICKRRV--- ---------- ---------- FNNMAWWGAK K-LFRRGYYH PTTDDDDTTT GGRLNNFRRQ QQEEELQTTT GDGG-----L FDDMSWWGAN N-KWRRGWWK NVVEEDDSSS GGRLNNFKKS SSTTTLQTTT GDGG-----L REESSPPDEI I-MAEESSSE SFFKKTTPPP PPHVAAELL- ---------- ---------- KNNMTFFTGS SNMMFFGQQM LQQEEAAKKK GGTIVVQDDH HHTQQPKVVV PP-------L KNNLTFFTGN NNMMFFGKKM LAAEEAAKKK GGTVVVTDDH HHTQQPKVVV PP-------L -ELPPHHHDT KKLLMGIIVV VSSSLWLLWW FYYDDGGKKK WEEEEIIPEE PLGNNLLPII -EVPPHHHDT KKLLMGVVVV VNNNLWLLWW FYYDDGGKKK WEEEEIIEQQ PFGPPLLPVV -EVPPHHHDV RREEYGVVVV VDDDLWTTWW WRRGGGGKKK FKKKKAIPEE PAAEELLPLL -EVPPHHHDV RREEYGVVVV VDDDLWTTWW WRRGGGGKKK FEEEEAIPEE PAKKKLLPLL -EIPPHHHDS KKDDYGCCVV VDDDLFTTWW WQQDDGGTTT FKKKKIIDVV PAADDLLPLL -ELPPHHHDT KKAAYGVVVV VSSSLWTTWW YRRKKDDKKK WRRRRIIPEE AAPQQLLPVV -ELPPHHHDT KKAAYGMMVV VSSSLWLLWW YRRNNGGSSS WKKKKIIPEE PAEQQLLPII -ELPPHHHDA RRTTYGVVVV VSSSLWLLWW HRRNNGGSSS WRRRRIIPEE PAPQQLLPLL LEIFFHHHDS AATTQGVVAA ASSSQNEEEE G--------- -----TSVKK VIVSSKKKKK LEIFFHHHDD AATTQGVVAA ASSSQNEEGG G--------- -----TSVKK VIVSSKKKKK LEIFFHHHND AAAAQGVVAA ASSSQNQQGG G--------- -----TSVKK VIVPPKKKKK LEIFFHHHND AAAAQGVVAA ASSSQNEEDD G--------- -----TSAKK VIVPPKKKKK LEIFFHHHND AAAAQGVVAA ASSSQNEEGG G--------- -----TSVKK VIVPPKKKKK LEIFFHHHND AAAAQGVVAA ASSSQNEEGG G--------- -----TSVKK VIVPPKKKKK LEIFFHHHND AAAAQGVVAA ASSSQNEEGG G--------- -----TSVKK VIVPPKKKKK LEIFFHHHND AAAAQGVVAA ASSSQNEEGG G--------- -----TSVKK VIVPPKKKKK LEIFFHHHDA AASSQGVVAA ASSSQNEEGG G--------- -----TSVKK VIVPPKKKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LCLSSHHHWN IINNQDDDEE ESSSRPDDAA Y--------- -----AVLRR KLLYYAAVAA LEIFFHHHDD AAAAQGVVAA ASSSFEKKDD G--------- -----KAAKK VIVSSKKKEE LEIFFHHHND AADDQGVVAA ASSSFEKKDD G--------- -----KAAKK VIVSSKKKEE LEIFFHHHDA KKDDTGVVAA ASSSITQQDD G--------- -----SSHLL AIVPPLLKQQ LEIFFHHHDA KKDDTGVVAA ATTTITQQDD G--------- -----SNHII VIVPPLLKQQ LEIFFHHHDS KKDDTGVVAA ASSSINSSDD D--------- -----TSYII VIVPPLLKEE LEIFFHHHDS KKDDTGVVAA ASSSINSSDD E--------- -----TSHVV VIVPPLLKEE LEVFFHHHDS KKDDTGVVAA ATTTVTAADD G--------- -----SSHVV AIIPPLLKRR LEVFFHHHET SSEEHAVVAA AGGGFVEEEE NSS------- -----TAALL VAISSKKKSS LEVFFHHHET SSEEHAVVAA AGGGFDEEKK NPP------- -----VTALL VAISSKKKEE ---------- ---------- ---------- ---------- ---------- ---------- LEIFFHHHNR EENNQGVVAA AXXXX----- ---------- ---------- -------QEE LEIFFHHHNK KKAAEGVVAA ANNNFKSSDD SDD------- -----EKKII DIGLLVVDGG ---------- ---------- ---------- ---------- ---------- ---------- LEIFFWWWGN AANNYASSAA ATTTWDDDAA G--------- ---------- --WAAKKAAA LEICCWWWGA HHNNYCTTAA ATTTWDGGEE G--------- ---------- --WAAKKAAA LPFFKAVVVP PPLVTDDDII SLDDKKKFLL SSWWWIEVRR RQYYDDISPF KPVGKKKKLG LDFFKMVVVP PPLVTDDDII SLDDRRRFVV SSWWWLELRR RQYYDDITPH QPRGRRKKIG LGFFGAVVVP PPLVTDDDLL SLDDRRRFVV SSWWWTEMRR RQYYDDVSPH NPVGSSRRIG LGFFGAVVVP PPLVTDDDLL SMDDRRRFVV SSWWWTEMRR RQYYDDVSPR KPKGSSHHIG LGFFGACCCP PPLVTDDDLL SLDDKKKYVV AAWWWLEMHH HQYYDDVSPM NPVGKKEEIG LGFFKAVVVP PPLVTDDDLL SMDDRRRFVV SSWWWTDLLL LQYYDDVSPF EPKGKKRRIG LPFFKAVVVP PPLVTDNNLL SVDDRRRFVV SSWWWTELHH HQYYDDVSPF NPRGKKQQIG LDFFGAVVVP PPLVTDNNLL SLDDRRRFVV SSWWWTELRR RQYYDDVSPF NPRGSSRRLG GMLLPEMMMP PGLITDLLLL SLDDRRRFFF SSWWWHDIRR RQYYDDISPQ KPRGQQFFLG GMLLPEMMMP PGLITDLLLL SLDDRRRFFF SSWWWHDIRR RQYYDDISPK KPRGQQFFLG GMLLPEMMMP PGLITDLLLL SLDDRRRFFF SSWWWHDLRR RQYYDDISPQ RPRGQQFFLG GMLLPEMMMP PGLITDLLLL SLDDHHHFFF SSWWWHDIRR RQYYDDVSPQ RPRGQQFFLG GLLLPEMMMP PGLITDLLLL SLDDRRRFFF SSWWWHDLRR RQYYDDISPQ RPRGQQFFLG GLLLPEMMMP PGLITDLLLL SLDDRRRFFF SSWWWHDLRR RQYYDDISPQ RPR------- GLLLPEMMMP PGLIT----- ---------- ---------- ---------- ---------- GLLLPEMMMP PGLITDLLLL SLDDRRRFFF SSWWWHDLRR RQYYDDISPQ RPRGQQFFLG GMLLPEMMMP PGLITDLLLL SLDDRRRFFF NNWWWHDMRR RQYYDDISPK RPRGQQFFLG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KGVVVSLLLS SNEFPPWWII FFSSLLLLFF LL-------- ---------- ---------- GALLPEMMMP PGLITDLLII SLDDRRRFFF SSWWWHDIRR RQYYDDITPR NPKGQQFFLG GPMMPEMMMP PGLITDLLII SLDDRRRFFF SSWWWHDIRR RQYYDDITTR NPKGQQFFLG NILLPEMMMP PGLITDLLII SLDDRRRFFF VVWWWHDIRR RQYYNNIELK NPVGQQWWVG NFLLPEMMMP PGLITDLLII SLDDRRRFFF VVWWWHDIRR RQYYNNIEVK NPKGQQWWAG NILLPEMMMP PGLITDLLII SLDDRRRFFF VVWWWHDIRR RQYYNNIEPK NPVGQQWWVG NILLPEMMMP PGLITDLLII SLDDRRRFFF VVWWWHDIRR RQYYNNIEPK NPVGQQWWVG NILLPEMMMP PGLITDVVII SLDDRRRYLL VVWWWHDIRR RQYYNNIEPA KPVGQQWWAG GALLPEMMMP PALITDLLII SMDDRRRFVV SSWWWHDIRR RQYYDDISPL KVKSQQYYIG NALLPDMMMP PALITDLLII SMDDRRRFVV SSWWWHDIRR RQYYDDISPK NPKSQQFFIG ---------- ---------- ---------- ---------- ---------- ---------- NEIIEMMMMG GGMMTDLLII SLDDRRRYFF SSWWWHDVRR RQYYDDISRA NPRGQQFFLG SVAAEDMMMG GGMISDIIII SLDDRRRFVV NNWWWHDVRR RQYYDDITPE NPKGQQFFLG ---------- ---------- ---------- ---------- ---------- ---------- DGNNPADDDI IPLPVDSSII AADDQQQTII NNFFFDKTRR RLFFDDISPH KPFYEEVVIR DGEEPAKKKV VPLPVDSSII SNDDSSSRVV NNFFFDKTRR RLFFDDISPH HPRYEETTIA GGIFFRDDDH P--------- ---------- ---------G GKKTGAQIIR GRRYTNNNLT GGLYYRPPPH P--------- ---------- ---------G GEETGAQVVR GRRYTNNNLS GGIAARPPPH P--------- ---------- ---------G GTTAGGQIIR GRRYTNNNLT GGIAARPPPH P--------- ---------- ---------G GAAAAGQIIR GRRYTNNNLT GGIVVKPPPH P--------- ---------- ---------G GTTGYGQIIR GKRYTNNNLT GGIVVRTTTH PGGG------ ---------- ---------N NAANGGQIIR GRRYTNNNLA GGIVVRGGGH P--------- ---------- ---------S SEENGGQIIR GRRYTNNNLA GGIVVKAAAH P--------- ---------- ---------S SPPNGGQVVR GRRYSNNNLS GGSIIRGGGS VQQQVLEE-D QEELLLTQQQ QEEEPLLVVG GRRPGGQLLL GKRYTTTTLD GGSIIKGGGS VQQQVLEE-D QEELLLTQQQ QEEEPLLVVG GRRPGGQLLL GKRYTTTTLA GGSIIKGGGP VQQQVLEE-D QEELLLKQQQ QEEEPLLVVG GKKPGGQLLL GKRYTTTTLA GGSIIKGGGP VQQQVLDD-D QEELLLDQQQ QEEEPLLVVG GQQAGGQLLL GKRYTTTTLA GGSIIKGGGP VQQQVLEE-D QEELLLKQQQ QEEEPLLVVG GRRAGGQLLL GKRYTTTTLA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGSIIKGGGP VQQQVLEE-D EEELLLKQQQ QEEEPLLVVG GRRAGGQLLL GKRYTTTTLA GGSIIKGGGP VQQQVLEE-D QEELLLKQQQ QEEEPLLVVG GRRPGGQLLL GKRYTTTTLD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGSIIRGGGP VTTTVLEE-D KDDLLLEQQQ QDDDPVVIIG GKKPGGQLLL GKRYTNNNLK GGSIIRGGGP VTTTVLEE-D KEELLLEQQQ QDDDPVVTTG GIIPGGQLLL GKRYTSSSLI GGLIIKSSSP VAAAAIGG-E DGGKKKTQQQ QDDDVPPEEG GKKRGGQLLL GKRYTNNNLA GGLIIKSSSP VVVVAVKK-D DGGEEETQQQ QDDDVPPEEG GKKRGGQLLL GKRYTNNNLA GGLLLKSSSP VKKKAVGG-E DGGNNNSQQQ QDDDVPPQQG GSSRGGQLLL GKRYTNNNLA GGLLLKSSSP VKKKAVGG-E DGGNNNTQQQ QEEEVPPQQG GSSRGGQLLL GKRYTNNNLA GGLLLKSSSE VVVVYVTT-E DDDKKKEQQQ QSSSVPPQQG GRRRGGQLLL GKRYTNNNLR GGSVVTSSSN VKKKVLEE-G EKK----PPP PEEEALLYYG GKKEGGQLLL GKRYTTTTLK GGSIISTTTT VKKKVLEE-E DHHDDD-EEE EPPPALLYYG GQQEGGQLLL GKRYSTTTLK ---------- ---------- ---------- ---------- ----GGALLV GKRYTNNNFT GGAIIRAAAP RRRRVLNN-D PEELLLKAAA AEEEPVVFFG GRRLGGQLLL GRRYSSSSLP GGAIISLLLP NVVVIVKKED KEELLLKRRR RPPPARRYYG GRREGGQLLL GKRYSSSSLP ---------- ---------- ---------- ---------- ---------- ---------- RRQVV----- ---------- ---------- ---------- -------QQW GKRYSSSSLN AAQVV----- ---------- ---------- ---------- -------SSW GQRYTSSSLN NQYYPEGKKG GMVVVKKKNA N---LEIDKK KFFFVDDFGE ----RSHQGG GSSYCPP--- NQYYP-GRRG GMAAAKKKNV N---LELEKK KFFFVDDFGR ----RAHQGG GSSFCPP--- DQYYPDGPPA AQVVVLLLHA G---LTLADD DYWWVEEFPD G---RAHQGG GSSFCPPVV- DQYYPDGPPG GEVVVMMMNV G---LELDKK KYFFVSSFPD G---RAHQGG GSSFCPPVV- EQYYPGDGGA AMVVVMMMNV G---LTLDKK KFWWVDDFPA G---RSHQGG GSSFCPPVV- PQYYPEGDDG GMVVVKKKDA G---IEFDPP PFFFLEEWPK G---RPHQGG GSSYCPP--- EQYYPDGKKG GMVVVKKKDV N---MQFDPP PFFFVDDFGE ----RVHQGG GSSYCPP--- EQYYPVGRRG GIAAAKKKEA D---LSLDPP PFFFTEEVGD G---RPHQGG GSSYCPP--- KQYY-PDIIR RGSSSVVVLQ VDVTLKLNPP PFLLVDDFGK ELLPLAHEGG GIIWI----- KQYY-PNIIR RGSSSVVVLQ IDVTLKLNPP PFLLVDDFGK ELLPLAHEGG GIIWI----- KQYY-PDIIR RGSSSVVVLQ IDVTLKLNPP PFLLVDDFGK ELLPLAHEGG GIIWL----- KQYY-PDIIR RGSSSVVVLQ IDVTLTLNPP PFLLVDDFGK ELLPLAHEGG GIIWL----- KQYY-PDIIR RGSSSVVVLQ VDVTLKLNPP PFLLVDDFGK ELLPLAHEGG GIIWI----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KQYY-PDIIR RGSSSVVVLQ VDVTLKLNPP PFLLVDDFGK ELLPLAHEGG GIIWI----- KQYY-PDIIR RGSSSVVVLQ IDVTLKLNPP PFLLVDDFGK ELLPLAHEGG GIIWL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KQYY-PDIIK KGSSSVVVLQ IDVTLKLNPP PFLLVDDFGK EGGPLAHEGG GIIWV----- KQYY-PDLLK KGAAAVVVLQ IDVTLKLNPP PFLLVDDFGK EDDPLAHEGG GIIWI----- KQYY-PGVVE EGSSSHHHLQ IDVTLKINPP PFFFVDDFGA EDDPLAHEGG GIIWI----- KQYY-PKVVE EGSSSHHHLQ IDVTLKINPP PFFFVDDFGA EDDPLAHEGG GIIWI----- RQYY-PEMMD DGSSSHHHIQ IDVTLSINPP PFFFVDDFGD EEEPLAHEGG GIIWI----- VSYY-PEMME EGSSSHHHIQ IDGTLTINPP PFFFVDDFGD EDDPLAHEGG GIIWI----- EQYYGQDVVK KGSSSHHHLQ IDVTLSINPP PFFFVDDFGA EEEPLAHEGG GIIWI----- DQYY-PEVVK KGAAATTTVQ VNIPMEINRR RFLLIDDFGK IGGPLAHEGG GIIWI----- DQYY-PEVVR RGAAATTTLQ IDVPMVINKK KFLLIDDFGK VGGPLAHEGG GIIWI----- KQYY-PNVVK KGSSSVVVLQ IDVTLTVNKK KFLLVDDFGK ENNPLAHDGG GIILA----- KQYY-PEVVA AGGGGTTTVQ LDIVMKLNEE EFLLVDDFGG EYYPLPHE-- ---------- KQYY-PKVVS SGGGGHHHVL IDVTISLNEE EFLLVDDFAN EYYPLPHEGG GIIWLNNAA- ---------- ---------- ---------- ---------- ---------- ---------- ---------K KGKKKDDDAQ YLKYKELVEE EFAAVDDFYE LLL-RAHISS S--------- ---------K KGKKKDDDEQ FLKYKELKEE EFAAIDDFYA ELL-RPHQRR RPPAGGGRRQ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AARRVEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158AKKKKKKSAP PTAAVVPLAD GGAAMQSSLP PRTTTTLLSL TPSPPVVRRI AAYQQQWTFS gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- --MAAAAPTL gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSAIQQQQLL SPSSSGTSVP PGGISSAVVK VPPQQQVVQW AAAHHHLLLP PGAAVIIIAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------E ERFFTQQQAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMMLLLK KETTAPPPLL ---------- ---------- ---------- ---------L LLLKKKSSSG GCQQTTTTHH ---------- ---------- ---------- ---------- ---------- ---------- PPPLNNNNRR TPPPPASPHP PRRTRRVRRY TNNPPPLLPC PPPPPPAAAH HSHHIEEEAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----AAALL ---------- ---------- ---------- ---------- ---------- -----GGGLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMMR RR-------- ---------- ---------- ---------- ---------- ------MMMR RFPPSHHHLL ---------- MMAIVVVVPP PPPFFDPPFY PPPMMMAMAP PDDLLYYYVA AACCLLYYGT ---------- ---MAAAAKK KKKLLDPPFY PPPDDDAMAP PDDIIYYYVA AAAALLYYGT ---------- ----MMMMSS SSSMMDPPFH AAPLLLAMAP AEEFFYYYTL LLLLLLSSDF ---------- ----MMMMTT TTTMMDPPFH AAPLLLAMAP ANNFFYYYTL LLLLLLSSDF ---------- ----MMMMTT TTTLLDPPFY PPALLLAMGP VKKLLFFFTL LLMMLLSSDA ---------- ---MAAAATT TTTWWDPPFY PPPLLLAAAP PTTIIYYYVA AAMMFFDDER ---------- ---MVVVVTT TTTWWDPPFY PPPMMMAVAP AKKLLYYYVV VVRRLLNNMA ---------- ---MAAAASS SSSWWDPPFY PPPMMMAMAP RRRLLYYYVA AALLLLDDGR --------MA TTKCTTTTKK KKK--GPPYP TTLAAAMKGP REEIIYYYLP PPCCIIYYNT ---------- ---------- ---------- -------MGP REEIIYYYLP PPCCIIYYNT ALLLLPGAHS TTQCGGGGKK KKK--GPPYP SSLAAAMKGP REEIIYYYLP PPCCIIYYNT ---------- ---------- ---------- ------MKGP REEIIYYYLP PPCCIIYYNT --------MA TTKCGGGGNN NNN--GPPYS TTLAAAMKGP REEIIYYYLP PPCCIIYYNT AMMRRPISTA TTKCGGGGNN NNN--GPPYS TTLAAAMKGP REEIIYYYLP PPCCIIYYNT --------MA TTKCGGGGNN NNN--GPPYS TTLAAAMKG- ---------- ---------- --------MA TTKCGGGGNN NNN--GPPYS TTLAAAMKGP REEIIYYYLP PPCCIIYYNT LQQLLWQDTA TTKCGGGGDD DDD--GPPYP TTQAAAMKGP REEIIYYYLP PPCCIIYYNT HCCTTLVTSP TTKCGGGGNN NNN--GPPYS TTLAAAMKGP REEIIYYYLP PPCCIIYYNT --------MA TTKCGGGGNN NNN--GPPYS TTLAAAMKGP REEIIYYYLP PPCCIIYYNT AEETTAAANG KKTCCCCCHH HHHTTGPPYA TTLAAAMEGP RKKLLYYYVT TTCCVVYYGT ---------- ---------- ---------- ---------- ---------- ---------- ---------M AAKCGGGGSS SSS--GPPYK SSLAAAMKGP REEIIYYYLP PPCCIIYYST LGGVVVNKKS --VNGGGGCC CCCCCGPPYA SSISSSMSGP RSSLLYYYVT TTAAVVYYGT LAAVVVSKVN NNQQGGGGCC CCCCCGPPYA SSLAAAMSGP RTTLLYYYVT TTAAVVYYGT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---RMMMMLL LLLQQGPPYA TTLAAAMSGP SKKLLYYYVT TTAAVVYYGT ---MMAAANG AAACCCCCGG GGGGGGPPYA TTLAAAMEGP RKKLLYYYVT TTCCVVYYGT -----MSNCG LLKCHHHHGG GGG--GPPYA SSAAAAIKGP REEVVFFFVT TTAAPP---N -----MP-CP LLKCHHHHGG GGG--GPPYA SSAAAAIKGP REEVVFFFVT TTAAPP---H ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMSESSSSKK KKKCCGPPYA TTLAAAVRGP VKKLLYYYVV VVCCVVQQNL ---------- ---------- ---------- ------MRGP RKKLLYYYTV VVTTVVQQNL ---------- ---------- -----MPPLI TT-IIILILD DFFLLFFFSN NNWWLLHHDI -LLAAAGALA MMGLPPPPFF FFFRRADDTC QQPMMMPKTG QEEFFYYYVW WWTTLLGGEG LLLVVSGALA LLAAPPPPAA AAAGGADDTC AAPMMMKKTG QDDYYYYYVW WWTTLLGGEG GNNRRFIIAV VVVNPSSTSI IVHHHKVLPP YNDELHHHGN ACSSAAAALL -----PG--K GNNAAFLLAV VVVDPSSTGV VIYYYKLLPP YGDELHHHGN ACSSAAAAYY -----PA--K S--RRALLAV VVVKPSSTGI IVHHHTVMPP NGDEFHHHGN ACSSSSSSLL -----PTGGH S--KKALLAV VVVKPSSTGI IVHHHTVMPP NGDEFHHHGN ACSSAAAALL -----PAGGH S--KKGLLAV VVVDPSSKGI IVHHHQLMPP NGDEFHHHGN ACSSAAAALL -----PTGGH K--QQAIIAV VVVDPSSRAI IVGGGQVMPP HGDELHHHGN ACSSCCCCLL -----PAPPH N--KKAMMCV VVVDSSSTGV VVGGGVTMPP YGGELHHHGN ACSSMMMMLL -----PAPPH E--RRALLGV VVLDPSSTAI IVGGGRVMPP NADELHHHGN ACSAAAAALL -----PAPPH GEEAAYLLAT TTVDPSSQSV VIHHHRLMPP YKDELHHHGN TCSSCCCC-- ------FGGD GEEAAYLLAT TTVDPSSHSV VIHHHRLMPP HKDELHHHGN TCSSCCCC-- ------FGGD GEEAAYLLAT TTIDPSSQCV VIHHHRLMPP NRDELHHHGN ACSSCCCC-- ------FGGD GEEAAYLLAT TTVDPSSQCV VIHHHRLMPP HKDELHHHGN TCSSCCCC-- ------YGGD GEEAAYLLAT TTVDPSSQCV VIHHHRLMPP NKDELHHHGN TCSSCCCC-- ------FGGD GEEAAYLLAT TTVDPSSQCV VIEEE----- ---------- ---------- ---------- -EEAAYLLAT TTVDPSSQCV VIHHHRLMPP NKDELHHHGN TCSSCCCC-- ------FGGD GEEAAYLLAT TTVDPSSQCV VIHHHRLMPP NKDELHHHGN TCSSCCCC-- ------FGGD GEEAAYLLAT TTVDPSSQSV VIHHHRLMPP YKDELHHHGN TCSSCCCC-- ------FGGD GEEAAYLLAT TTVDPSSQCV VIHHHRLMPP NKDELHHHGN TCSSCCCC-- ------FGGD GEEAAYLLAT TTVDPSSQCV VIHHHRLMPP NKDELHHHGN TCSSCCCC-- ------FGGD GNNKKYLLAT TTLDPSSTSV VIHHHRLVII HGDKLHHHGN SCSSCCCC-- ------HGGD ---------- ---------- -------MPP NNDELHHHGN TCSSCCCC-- ------YGGD GNNKKYLLAT TTVDPSSSSV VIHHHRLMPP NNDELHHHGN TCSSCCCC-- ------YGGD GEEKKYLLAT TTVDPSSTSV VIHHHRLVPP YGDELHHHGN SCSSCCCC-- ------HGGD GEEKKYLLAT TTLDPSSTSV VIHHHRLVPP YGDELHHHGN SCSSCCCC-- ------HGGD ---------- ---------- -------MPP FGDELHHHGN SCSSCCCC-- ------HGGD GDDKKYLLAT TTVDPSSSSV VIHHHRLMPP FGDELHHHGN SCSSCCCC-- ------HGGD GNNKKYLLGT TTVDPSSTSV VIHHHRLVTT HGDELHHHGN ACSSCCCC-- ------HGGD ADDGGAIIFT TTVNPSSTCV VISSSRVVPP HGDEVHHHGN ACSSCCCC-- ------HDDK ADDGGAIIFT TTVNPSSTCI IISSSRVVPP NGDEVHHHGN ACSSCCCC-- ------HDDK ---------- ---------- ---------- ---------- ---------- ---------- DEEHHYLLAT TTVDPSSTCV VIHHHRTTNN SHNELHHHGN TCSSCCCCHH VVVVVPGGGK DPPHHYLLST TTVDPSSTCI IVHHHRTTNN RGDELHHHGN ACSSCCCCYY VVVVVDSSSK RYYDDDRRKN NNMVGVVLGV VLKKKDGVKK VEDKELLDQT PRILKKKK-- -------GGK MDDEEKLLVT TTLRPSSTGV VINNNSVVGG GRNEAHHHGS A--------- ---------- VDDEEKLLVT TTANPSSQGV VVNNNTLVGG GRNEAHHHDT D--------- ---------- EERRFIVGLL LSSSSRRIII IDTKKPREPV IEPPEEVKKV VYSSRLHCCG GPDAIYYYYS EERRYIVALL LSSSSRRIII VDTKKPRRPI VEPPEEAVVR RYTTKYHCCG GPDAIYYYYS EERRFIIGLL LSSSSRRIIV IDTKKPTQAI IEPPDDILLK KYSSRPHCCG GPEGIYYYYS EERRYIIGLL LSSSSRRIII IDTKKPTKAI IEPPEEVFFK KYSSRPHCCG GPDGIYYYYS EERRYIIGII ISSSSRRIII VDVKK-LKAI IEPPEEVFFK KYSSRPHCCG GPEGIYYYYS EERRYVVGLL LSSSSRRIII LDTKKPLKPV IEPPEELAAR RYSSRPHCCG GPGGIYYYYT EERRYVVDII ISSSSHHIII LDTKKPTQPV IDPPNNLAAR RYAARPHCCG GPDGIYYYYS EERRYIVGII ISSSSRRIII VDTKKPREPV IEPPEELHHR RYSSRPHCCG GPDGVYYYYS SSRRKILGLL LSSSSRRIIV VDVGGSRAPV IEAASSIQQK KVSSNTHCCL LASGEVVVVV SSRRKILSII ISSSSRRIIV VDVGGSRAPV IEPPNNIHHK KLGGNLHCCL LASGEVVVVI SSRRKMLCLL LSSSSRRIIV VDVGGSRAPV IEAAEEIHHK KLGGYVHCCL LASGEVVVVI AARRKVLALL LSSSSRRIIV VDVGGTRAPV IEPPKKIHHK KLGGFFHCCL LPSGEVVVVV SSRRKVLSLL LSSSSRRIIV VDVGGSRAPV IEPPEEIHHK KLAAFLHCCL LASGEVVVVI ---------- ---------- ---------- --PPKKIHHK KLAAFLHCCL LASGEVVVVI SSRRKVLSLL LSSSSRRIIV VDVGGSRAPV IEPPKKIHHK KLAAFLHCCL LASGEVVVVI SSRRKVLSLL LSSSSRRIIV VDVGGSRAPV IEPPKKIHHK KLAAFLHCCL LASGEVVVVI SSRRKVLSFF FSSSSRRIIV VDVGGTRAPV IEAAKKIHHK KLGGTPHCCL LPTGEVVVVI SSRRKVLSLL L--------- ---------- ---------- ---------- ---------- SSRRKVLSLL LSSSSRRIIV VDVGGSRAPV IEPPKKIHHK KLAAFLHCCL LASGEVVVVI KKRRFILSLL LSSGGRRVVV VDTAATRTPV VESSEEIAAN NLGGFPHCCL LASGDIIIII VVRRKILCLL LSSSSRRIIV VDVGGTRAPT VEPPYYVFFK KLAANLHCCL LGCGEIIIII VVRRKILCLL LSSSSRRIIV VDVGGSRAPT VEPPYYVFFK KLAANPHCCL LGCGEIIIII EERRFIASLL LSSGGRRIIV IDTKKTRSPV VDPPAAIIIK KLAAYPHCCL LASGELLLLI QQRRFIVGII ISSGGRRVVV IDTKKTRAPV VEPPEEISSK KLAAYPHCCL LASGEIIIII DDRRYVLSLL LSSGGRRIIA IDTKKERAPY VDPPKKIAAK KLAAYPHCCL LASGEIIIIV DDRRYVLSLL LSSGGRRIIA IDTKKERAPY VDPPKKIAAK KLAAFPHCCR RT-GEIIIIV SSRRFILSLL LSSGGRRVVV VDTLLKRAPV VEAAEEIAAK KLGGFPHCCL LASGEIIIII KKRRHIVCLL LSSDDRRIII INVEENRKIT IEPPSSLHHL LLSSFPHCCL LADGNIIIII KKRRHIVCLL LSSDDRRIIV INVEENREIT IEPPSSLHHL LLSSFPHCCL LADGNIIIII -----VPKLL LSSGGVVEEK VFVGGG---- ---------- ---------- ---------- TTRRRVLCLL LSSDDRRIIV IDTGGTRAPV IEGG--VLLG GCTTAPHCCL LPNGNIIIII KKRRRVLSLL LSSDDFFIII LDVVVTRKPT IDGG--VLLS SVTTAPHCCL LANGNIIIII GGGGQLQSLL LGGKKRRLLV TTSLLYWDK- ------LIIF FLAAISHYYQ QPNTALLLLQ DDRRFWTGLL LTTNNRRIII FDVHHSSNPT IDTT--VKKS SVVVGPHAAL LPGSMMMMMT DDRRYWAGLL LTTSSKKIIV FDVHHSARPT ITDD--VEES SVVVGPHAAL LPGRMLLLLT ALLLGGGGNN NEE----EGG --PGLLMMLD DYSSFFFFEE PLWWIDRGGY ---------- ALLLGGGGGG GPP----DGG RRPGFFLLLD DDTTFFFFEE PIWWVYRGGY ---------- TLLLGGGGGG GAAGKKKDGG TTAGFFIIMD DETTFFFFDD VLWWIDRGGD ---------- TLLLGGGGGG GGGGKKKDGG TTPGFFIIMD DETTFFFFEE VLWWIDRGGT ---------- TLLLGGGGGG GGGGEEEDGG TTPGFFIILD DETTFFFFEE ILYYMDRGGT ---------- ALLLGGGGNN NAA----EGG --PGAAMMLD DQSSFFFFEE PLWWVERGGY ---------- ALLLGGGGSS SPP----EGG --PGFFIILD DDNNLLLLEE VLWWIDRGGY ---------- ALLLGGGGSS SPP----EGG --PGFFVVMD DESSFFFFDD PLWWVERGGQ ---------- NTTTLLLLGG GDD----LQQ GGKSVVLLLD DETTFFFFEE VKWWKPGGGP ---------- SSSSLLLLGG GDD----PQQ GGKGVVLLLD DETTFFFFEE VKWWKPGGGP ---------- STTTLLLLGG GDD----SKK GGKGVVLLLD DETTFFFFEE VKWWQPGGGP ---------- STTTLLLLGG GDD----PEE GGKGVVLLLD DKTTFFFFEE VKWWQPGGGP ---------- SSSSLLLLGG GDD----VKK GGKGVVLLLD DETTFFFFEE VKWWRPGGGP ---------- SSSSLLLLGG GDD----VKK GGKGVVLLLD DETTFFFFEE VKWWRPGGGP ---------- SSSSLLLLGG GDD----VKK GGKGVVLLLD DETTFFFFEE VKWWRPGGGP ---------- SSSSLLLLGG GDD----VKK GGKGVVLLLD DETTFFFFEE VKWWRPGGGP ---------- STTTLLLLGG GDD----PKK GGKGVVLLLD DETTFFFFEE VKWWRPGGGP ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSSSLLLLGG GDD----VKK GGKGLLVVLL L-RRLLLLEE CS-------- ---------- SCCCLLLLGG GDD----KEE GGANFFLLLL LSEEFFFFNN VKGGNRLFFS ---------- SSSSIIIIGG GDD----PYY GGKGVVLLLD DETTFFFFEE VKWWAEGEEP ---------- SSSSLLLLGG GDD----PCC GGKGVVLLLD DETTFFFFEE VKWWVEGEEQ ---------- SCCCLLLLGG GDD----KDD GGENFFLLLL LSDDFFFFNN VKWWKPGHHL ---------- SCCCIIIIGG GDD----KDD GGENFFLLLL LSEEFFFFNN VKWWKPGHHL ---------- SCCCLLLLGG GDD----EEE GGKNFFLLLL LSDDFFFFNN IKWWKPGHHL ---------- SCCCLLLLGG GDD----EEE GGKNLLLLLL LSDDFFFFNN IKWWKPDIIL ---------- SCCCLLLLGG GDD----KEE GGANFFLLLL LSEEFFFFNN VKWWKPGHHL ---------- STTTLLLLGG GEE----ANN GGSNLLLLLD DKTTFFFFEE PKWWADEKKP ---------- STTTLLLLGG GEE----ADD GGSNLLLLLD DKTTFFFFEE PKWWADGKKP ---------- ---------- ---------- ---------- ---------- ---------- ---------- SIIIMMMMGG GDD----AEE GGK-FFVVEF FKNNFFFFEE LVWWRGDRRL ---------- SVVVMMMMGG GDD----AEE GGK-FFIILF FSDDFFFFNN CIWWKGDKKL ---------- DGGGVVVVNN NEE----SLL SSVNIIQQTS SHEENNNNGG LSGGASQFFI ---------- GLLLSSSSNN NDD----DDD HHRAVVEEYN NDGGEEEEYY VAWWPTADDQ GGVAVGDAAA GLLLSSSSNN NNN----KDD HHRAVVEEYT TAGGEEEEYY VAWWPTDGGR GGIKTG-KKK ---AYDWWWN PEVVLSWVPN N---TDLLLK LLEEEEKKD- RRYRIHWLRR KKKRKIIHHH ---AYDWWWN PGVVMTWVPR R---CEFFFS LLEEEEKKEG AAYKLHWLAA KKKRRLLYYY ---HYDWWWN PDYYMSWLPP P---QNIIIV PPEEEELLAN KKYRLHWLRR AAARRVVQQQ ---HYDWWWN PDYYMTWLPP P---QNIIIV PPEEEELLSN KKYRLHWLRR AAARRVVQQQ ---HYDWWWN PDYYMSWLPP P---QNIIIV PPEEEELLSN KKYKIHWLRR DDDRKVVQQQ ---AYDWWWH GDTTLTWTPD D---MDLLLV PPDDDDLLGA RRYRLHWLTT RRRRRLLQQQ ---HYDWWWH GDTTLTWTPR R---MSVVVL GGDDDDLLAG KKYRLHWLYY RRRRRLLQQQ ---AYDWWWH GDTTMTWTPN N---MGLLLD PPQQQQLLNK GGYRLHWLRR RRRRRLLQQQ ---GYDYYYQ RNVVMSWAPN N---VDNNNP AAHHHHAA-G LLYRIFWWQQ RRRHEIIQQQ ---GYDYYYQ RNIIMSWAPN N---VDNNNP AAHHHHAA-G LLYHIHWWQQ RRRHEIIQQQ ---GYDYYYQ RNVVMSWAPN N---VDNNNP AADDDDAA-G LLYHLHWWQQ RRRHEIIQQQ ---GYDYYYQ RNVVMSWAPN N---VDNNNP AADDDDAA-G LLYHLYWWQQ RRRREVVQQQ ---GYDYYYQ RNVVMSWAPN N---VDNNNP AADDDDAA-G LLYHLYWWQQ HHHHEVVQQQ ---GYDYYYQ RNVVMSWAPN N---VDNNNP AADDDDAA-G LLYHLYWWQQ RRRHEVVQQQ ---GYDYYYQ RNVVMSWAPN N---VDNNNP AADDDDAA-G LLYHLYWWQQ RRRHEVVQQQ ---GYDYYYQ RNVVMSWAPN N---VDNNNP AADDDDAA-G LLYHLYWWQQ RRRHEVVQQQ ---GYDYYYQ RNVVMSWAPN N---VNNNNP AADDDDAA-G LLYHLHWWQQ RRRHEVVQQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------SHSN N---LTRRRD YYPPPPAA-S RRVIT----- ---------- ---ERTYYYE AGLLFSQCSL L---FTEEEL MMCCCCAA-S GGVISCDYII MMMRVDDEEE ---GYDYYYQ RNVVMSWAPK K---ALKKKM EEEEEEAA-G MMYSLNWWTT EEEHRIIQQQ ---GYDYYYQ RNVVMSWAPK K---ALKKKM EEDDDDAA-G HHYSLNWWTT EEEHRVVQQQ ---GYDYYYQ RNTTMSWAPT T---AKDDDL QQHHHHDD-G LLYHLTILAA RRRGERRQQQ ---GYDYYYQ RNTTMSWAPK K---AQNNNL QQHHHHDD-G LLYHLHYWPP GGGGEKKQQQ ---GYDYYYQ RKTTMSWAPK K---AKDDDL QQHHHHDD-G LLYHLHYWPP GGGGEKKQQQ ---GYHYYYQ RKTTMSWAPK K---AKNNNL QQHHHHDD-G LLYHLHYWPP GGGGEKKQQQ ---GYDYYYQ RKTTMSWAPA A---ATDDDL QQHHHHDD-G LLYHLHYWPP GGGGEKKQQQ ---NYDYYYQ RNVVMSWSPN N---HKNNNP AAHHHHEE-G LLYSVHFWDD SSSKKLLQQQ ---NYDYYYQ RNIIMSWSPN N---HKNNNP AAHHHHEE-G LLYSVHFWDD TTTKKLLQQQ ---------- -----SRGPV V---TREEEL KKCCCCEE-P LLVCKRY--- ---------- ---GYDYYYQ HNVVMAWAPK K---LRHHHP TTDDDDDDRT QQYRLNYWQQ EEEREFFQQQ ---GYDYYYQ YDVVMSWAPN N---KRKKKN VVDDDDDDMS QQYRLNYWSS TTTQTYYQQQ ---QLSNNNN -EKKSSPEPI I---MEEEES FFLLLLTTGP LLKHVAV--- ---------- AVVGYDAAAL RNVVMTFGWS SNYYMFMMML QQDDDDAAMK RRFTIVWLHH TTTRQKKKKK KYYDYDAAAL RNLLLTFGWN NNYYMFMMML AADDDDAAMK HHFTVVWLHH TTTKQKKKKK SLLENAL--- ----ELLLLP PLHDDDPPPT KKKLLMFINM VSLLKSIWWY YEEGGWWVVI AILQHVL--- ----EVVVVP PLHDDDPPPT KKKLLMFVNV VNTTKSIWWY YEEGGWWVVI TILAHAL--- ----EVVVVP PAHDDDPPPV RRREEYFVGV VDTTTSIWWR REEGGFFTTA TILAHAL--- ----EVVVVP PAHDDDPPPV RRREEYFVGV VDTTTSIWWR REEGGFFTTA TILAHAL--- ----EIIIIP PAHDDDPPPS KKKDDYFCGV VDTTTAIFFQ QDDGGFFTTI EIFDHVF--- ----ELLLLP PAHDDDPPPT KKKAAYFVNC VSLLKSIWWR RDDDDWWVVI TLLAYAL--- ----ELLLLP PAHDDDPPPT KKKAAYFMNC VSLLKSIWWR RDDGGWWVVI ALVEHVL--- ----ELLLLP PAHDDDPPPA RRRTTYFVGV VSLLESVWWR RQQGGWWVVI TLM-DIP--- -LLLEIIIIF FLHDDDPPPS AAATTQFVGC ASSSNYKNN- ---------T TLM-DIP--- -LLLEIIIIF FLHDDDPPPD AAATTQFVGC ASSSNYKNN- ---------T TLL-DIP--- -LLLEIIIIF FLHNNNPPPD AAAAAQFVGC ASSSTYKNN- ---------T TLL-DIP--- -LLLEIIIIF FLHNNNPPPD AAAAAQFVGC ASSSTFKNN- ---------T TLL-DIP--- -LLLEIIIIF FLHNNNPPPD AAAAAQFVGC ASSSTYKNN- ---------T TLL-DIP--- -LLLEIIIIF FLHNNNPPPD AAAAAQFVGC ASSSTYKNN- ---------T TLL-DIP--- -LLLEIIIIF FLHNNNPPPD AAAAAQFVGC ASSSTYKNN- ---------T TLL-DIP--- -LLLEIIIIF FLHNNNPPPD AAAAAQFVGC ASSSTYKNN- ---------T TLM-DIP--- -LLLEIIIIF FLHDDDPPPA AAASSQFVGC ASSSTYKNN- ---------T ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SLL-DGANNN PLLLCLLLLS SIHWWWKKKN IIINNQYDVV ESFFSSDPP- ---------A TILEDIP--- -LLLEIIIIF FLHDDDPPPD AAAAAQLVGC ASSSTYKEE- ---------K TILKDIP--- -LLLEIIIIF FLHNNNPPPD AAADDQLVGC ASSSSYKEE- ---------K TLLNTLP--- -LLLEIIIIF FLHDDDPPPA KKKDDTFVGS ASSSNFKTT- ---------S TLLDKLP--- -LLLEIIIIF FLHDDDPPPA KKKDDTFVGS ATSSNFKTT- ---------S LILETLP--- -LLLEIIIIF FLHDDDPPPS KKKDDTYVGS ASSSNFKNN- ---------T LILPTLP--- -LLLEIIIIF FLHDDDPPPS KKKDDTFVGS ASSSNFKNN- ---------T TLLSTLP--- -LLLEVVVVF FLHDDDPPPS KKKDDTYVGC ATSSNFKTT- ---------S TILQLLP--- -LLLEVVVVF FLHEEEPPPT SSSEEHFVGC AGSSGHPVVS S--------T TILMRLP--- -LLLEVVVVF FLHEEEPPPT SSSEEHFVGC AGSSAHPDDP P--------V ---------- ---------- ---------- ---------- ---------- ---------- TILDDTP--- -LLLEIIIIF FLHNNNPPPR EEENNQYVGC AXXXXX---- ---------- TILSDTP--- -LLLEIIIIF FLHNNNPPPK KKKAAEFVGC ANAAKKKKKD D------FFE ---------- ---------- ---------- ---------- ---------- ---------- VFVGP----- -LLLEIIIIF FPWGGGSSSN AAANNYFSTT ATSSQYEDD- ---------- VFVGP----- -LLLEIIIIC CAWGGGEEEA HHHNNYFTST ATSSQYEDD- ---------- IIIPPEEEPL LLLLEGG--L LEILKKKPPF FKPPLVIDSL LLSLERRRQQ YPPKKPVLKL IIIEEQQQPF FFFFEGG--L LPVLKKKDDF FKPPLVIDSL VVSLERRRQQ YPPQQPRLRI AIIPPEEEPA AAAATAADDL LPLLQQQGGF FGPPLVIDSL VVSCERRRQQ YPPNNPVLSI AIIPPEEEPA AAAAPKKEEL LPLLQQQGGF FGPPLVIDSL VVSCERRRQQ YPPKKPKLSI IIIDDVVVPA AAAADAADDL LDLLKKKGGF FGPPLVIDSL VVACEHHHQQ YPPNNPVLKI IIIPPEEEAA AAAADPPDDL LPVLKKKGGF FKPPLVIDSL VVSCDLLLQQ YPPEEPKLKI IIIPPEEEPA AAAASEEDDL LPILKKKPPF FKPPLVINSL VVSCEHHHQQ YPPNNPRLKI IIIPPEEEPA AAAAEPPDDL LPLLKKKDDF FGPPLVINSL VVSCERRRQQ YPPNNPRHSL TSSVVKKKVI IIIIQVVPPK KVKGWWWMML LPGGLIILSL FFSNDRRRQQ YPPKKPRLQL TSSVVKKKVI IIIIQVVPPK KVKGWWWMML LPGGLIILSL FFSNDRRRQQ YPPKKPRLQL TSSVVKKKVI IIIIQVVPPK KVKGWWWMML LPGGLIILSL FFSNDRRRQQ YPPRRPRLQL TSSAAKKKVI IIIIQVVPPK KVKGWWWMML LPGGLIILSL FFSNDRRRQQ YPPRRPRLQL TSSVVKKKVI IIIIQVVPPK KVKGWWWLLL LPGGLIILSL FFSNDRRRQQ YPPRRPRLQL TSSVVKKKVI IIIIQVVPPK KVKGWWWLLL LPGGLIILSL FFSNDRRRQQ YPPRRPRL-- TSSVVKKKVI IIIIQVVPPK KVKGWWWLLL LPGGLI---- ---------- ---------- TSSVVKKKVI IIIIQVVPPK KVKGWWWLLL LPGGLIILSL FFSNDRRRQQ YPPRRPRLQL TSSVVKKKVI IIIIEVVPPK KVKGWWWMML LPGGLIILSL FFNNDRRRQQ YPPRRPRLQL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AVVLLRRRKL LLLLDLLYYA AVAKFFFGGV VVNNEFAWFI FFLS------ ---------- KAAAAKKKVI IIIIKVVPPK KVEGWWWAAL LPGGLIILSL FFSNDRRRQQ YPPNNPKLQL KAAAAKKKVI IIIIQVVPPK KVEGWWWPPM MPGGLIILSL FFSNDRRRQQ YTTNNPKLQL SSSHHLLLAI IIIIPVVKKL LVQNWWWIIL LPGGLIFLSL FFVNDRRRQQ YLLNNPVLQV SNNHHIIIVI IIIISVVEEL LVQNWWWFFL LPGGLIFLSL FFVNDRRRQQ YVVNNPKLQA TSSYYIIIVI IIIISVVKKL LVENWWWIIL LPGGLIFLSL FFVNDRRRQQ YPPNNPVLQV TSSHHVVVVI IIIISVVKKL LVENWWWIIL LPGGLIFLSI FFVNDRRRQQ YPPNNPVLQV SSSHHVVVAI IIIISIIKKL LVRNWWWIIL LPGGLIFVSL LLVNDRRRQQ YPPKKPVLQA TAAAALLLVA AAAAFIIPPK KVSGWWWAAL LPAALIILSL VVSCDRRRQQ YPPKKVKLQI VTTAALLLVA AAAATIIPPK KVENWWWAAL LPAALIILSL VVSCDRRRQQ YPPNNPKLQI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -GENGGGEEI IEGGMMILSL FFSNDRRRQQ YRRNNPRLQL EKKKKIIIDI IIIIPGGKKV VTGSGGGVVA AEGGMIIISL VVNCDRRRQQ YPPNNPKLQL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----EWWQQK KVADIIIGGN NPPPLPISAL IINSKRRRLL FPPKKPFQEI ---------- ----EWWQQK KVADIIIGGE EPPPLPISSL VVNTKRRRLL FPPHHPRQEI GGGIIFFRAD D--------- -------AHL LGAAAPQQME ESRRGGGRRR YVVTNSDDNN GGGLLYYREP P--------- -------SAA AGAAAPQQMS SSRRGGGRRR YIITNSNNNN GGGIIAARAP P--------- -------NRF FGGGGPQQME ESRRGGGRRR YWWTNSDDDD GGGIIAARTP P--------- -------NKF FAGGGPQQME ESRRGGGRRR YWWTNSDDDD GGGIIVVKTP P--------- -------NKF FYGGGPQQME ESRRGGGKRR YWWTNSDDEE GGGIIVVRAT T--------- ------AKGL LGGGGPQQME ESRRGGGRRR YFFTNGDDPP GGGIIVVRAG G--------- ------ATAL LGGGGPQQME ESRRGGGRRR YFFTNRDDEE GGGIIVVKAA A--------- -------AGL LGGGGPQQME ESRRGGGRRR YFFSNADDEE GGGSSIIRGG GVVLL--DLL CQQPPLVKKI IGGGGPQQMQ QSLLGGGKRR YAATTSDDKK GGGSSIIKGG GVVLL--DLL CQQPPLVKKV VGGGGPQQMQ QSLLGGGKRR YVVTTSDDKK GGGSSIIKGG GVVLL--DLL SQQPPLVKKV VGGGGPQQMQ QSLLGGGKRR YVVTTSDDKK GGGSSIIKDG GVVLL--DLL SQQPPLVKKV VGGGGPQQMQ QSLLGGGKRR YVVTTSDDKK GGGSSIIKGG GVVLL--DLL SQQPPLVKKV VGGGGPQQMQ QSLLGGGKRR YIITTSDDKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGSSIIKGG GVVLL--DLL SQQPPLVKKV VGGGGPQQMQ QSLLGGGKRR YIITTSDDKK GGGSSIIKGG GVVLL--DLL SQQPPLVKKV VGGGGPQQMQ QSLLGGGKRR YVVTTSDDKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGSSIIRGG GVVLL--DLL CQQPPVVKKV VGGGGPQQMQ QSLLGGGKRR YVVTNSDDKK GGGSSIIRGG GVVLL--DLL CQQPPVVKKI IGGGGPQQMQ QSLLGGGKRR YVVTSSDDKK GGGLLIIKGS SAAII--EKK WQQSVPIQQL LGGGGPQQMQ QTLLGGGKRR YVVTNSDDKK GGGLLIIKGS SAAVV--DEE WQQSVPIQKL LGGGGPQQMQ QSLLGGGKRR YVVTNSDDKK GGGLLLLKGS SAAVV--ENN FQQFVPIKKL LGGGGPQQMQ QSLLGGGKRR YAATNSDDRR GGGLLLLKGS SAAVV--ENN FQQFVPIKKL LGGGGPQQMQ QSLLGGGKRR YAATNSVVVV GGGLLLLKGS SYYVV--EKK EQQYVPVKHL LGGGGPQQMQ QSLLGGGKRR YVVTNSDDEE GGGSSVVTES SVVLL--G-- -PPIALVKRI IGGGGPQQMQ QSLLGGGKRR YVVTTKDDDD GGGSSIISET TVVLL--EDD -EEIALVKRI IGGGGPQQMQ QSLLGGGKRR YVVSTKDDDD ---------- ---------- ---------- -GGGGPAAKQ QSVVGGGKRR YVVTNSDDKK GGGAAIIRDA AVVLL--DLL EAAPPVLKRL LGGGGPQQMQ QSLLGGGRRR YVVSSSDDKK GGGAAIISDL LIIVVEEDLL ERRPARVKRL LGGGGPQQMQ QSLLGGGKRR YVVSSSDDKK ---------- ---------- ---------- ---------- ---------- ---------- DDDQQVV--- ---------- ---------- --------MS SSWWGGGKRR YFFSSADD-- GGGQQVV--- ---------- ---------- --------MS SSWWGGGQRR YYYTSADD-- YYYPEEEGGG LKKGWKLNNN AN-----GLE IKFVVVDE-- RRHQQVSGSD SSYYYCYYYY YYYP---GGG LRRGWKVNNN VN-----GLE LKFVVVDR-- RRHQQVWGTD SSFFFCYYYY YYYPDDDGGG VPPAALAHHH AG-----GLT LDYVVVEDGG RRHQQIEGTD SSFFFCYYYY YYYPDDDGGG VPPGVMANNN VG-----GLE LKYVVVSDGG RRHQQIEGTD SSFFFCYYYY YYYPGGGDDD RGGAAMANNN VG-----GLT LKFVVVDAGG RRHQQIEGTD SSFFFCYYYY YYYPEEEGGG IDDGWKLDDD AG-----GIE FPFLLLEKGG RRHQQVQGSD SSYYYCYYYY YYYPDDDGGG IKKGWKVDDD VN-----GMQ FPFVVVDE-- RRHQQIQGSD SSYYYCFFFF YYYPVVVGGG IRRGWKAEEE AD-----GLS LPFTTTEDGG RRHQQIEGSD SSYYYCYYYY YYY-PPPDDD LIIREVMLLL QVDVVDDGLK LPFVVVDKEE LLHEELPGSD IIWWWI---- YYY-PPPNNN LIIREVMLLL QIDVVDDGLK LPFVVVDKEE LLHEELPGSD IIWWWI---- YYY-PPPDDD LIIREVMLLL QIDVVDDGLK LPFVVVDKEE LLHEELPGSD IIWWWL---- YYY-PPPDDD LIIREVMLLL QIDVVDDGLT LPFVVVDKEE LLHEELPGSD IIWWWL---- YYY-PPPDDD LIIREVMLLL QVDVVDDGLK LPFVVVDKEE LLHEELPGSD IIWWWI---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYY-PPPDDD LIIREVMLLL QVDVVDDGLK LPFVVVDKEE LLHEELPGSD IIWWWI---- YYY-PPPDDD LIIREVMLLL QIDVVDDGLK LPFVVVDKEE LLHEEIPGSD IIWWWL---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYY-PPPDDD MIIKEVMLLL QIDVVDDGLK LPFVVVDKEE LLHEELPGSD IIWWWV---- YYY-PPPDDD LLLKEVMLLL QIDVVDDGLK LPFVVVDKEE LLHEEIPGSD IIWWWI---- YYY-PPPGGG LVVEKHILLL QIDVVDDGLK IPFVVVDAEE LLHEEMPGSD IIWWWI---- YYY-PPPKKK LVVEQHILLL QIDVVDDGLK IPFVVVDAEE LLHEEMPGSD IIWWWI---- YYY-PPPEEE LMMDKHIIII QIDVVDDGLS IPFVVVDDEE LLHEEMPGSD IIWWWI---- YYY-PPPEEE IMMEKHIIII QIDGGDDGLT IPFVVVDDEE LLHEEMPGSD IIWWWI---- YYYGQQQDDD LVVKKHMLLL QIDVVDDGLS IPFVVVDAEE LLHEEMPGSD IIWWWI---- YYY-PPPEEE HVVKSTMVVV QVNIIDDKME IRFIIIDKII LLHEEMPGSD IIWWWI---- YYY-PPPEEE NVVRSTMLLL QIDVVDDHMV IKFIIIDKVV LLHEEMPGSD IIWWWI---- YYY-PPPNNN VVVKEVMLLL QIDVVDDGLT VKFVVVDKEE LLHDDIPGSD IILLLA---- YYY-PPPEEE MVVAATIVVV QLDIIDDGMK LEFVVVDGEE LLHEEM---- ---------- YYY-PPPKKK MVVSQHIVVV LIDVVDDGIS LEFVVVDNEE LLHEEMPGSD IIWWWLAAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---KKDDAAA QYLKKAAGKE LEFVVVDELL RRHIIMGSSS ---------- ---------- ---KKDDEEE QFLKKLLGKE LEFIIIDAEE RRHQQMGRAG PPAAAGDDDD ------- ------- RR----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- VVQAREE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNNAKKAKKQ EETPCRRRTV PPPTGGTTAA RLDDDSPPTT TAAQLLLSLL TTPPPPRRII gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKAYEEEATT TSAAIIQVAS SPPRRRSESS KRRSSVPPGG LLLVVVESSA VVVAAKKQQV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MGGGRPP PPPPLLNNTP PPPHHHPNPP APPPPHPPRR VVVPPPLRRV RRRPPYYRRT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMI VKKDDPPTTT FSPPMAMAPP ---------- ---------- ---------- ---------M AKKDDPPTTT FTPPDAMAPP ---------- ---------- ---------- ---------- MRRDDPPTTT FSPPLAMAPP ---------- ---------- ---------- ---------- MRRDDPPTTT FSPPLAMAPP ---------- ---------- ---------- ---------- MRRDDPPTTT FSAALAMGPP ---------- ---------- ---------- ---------M AKKDDPPSSS FSPPLAAAPP ---------- ---------- ---------- ---------M VRRDDPPTTT FSPPMAVAPP ---------- ---------- ---------- ---------M ARRDDPPTTT FSPPMAMAPP ---------- ---------- ---------- ------ATTC T--GGPPGGG YPLLAMKGPP ---------- ---------- ---------- ---------- ---------- ------MGPP VPPPSQWWAA HLLPPGKHGA ALAAPAARGL LLLLLGSTTC G--GGPPGGG YPLLAMKGPP ---------- ---------- ---------- ---------- ---------- -----MKGPP ---------- ---------- ---------- ------ATTC G--GGPPGGG YPLLAMKGPP ---------- ---AARAEGA FLSSVAAQPM MMMMRIATTC G--GGPPGGG YPLLAMKGPP ---------- ---------- ---------- ------ATTC G--GGPPGGG YPLLAMKG-- ---------- ---------- ---------- ------ATTC G--GGPPGGG YPLLAMKGPP ---------- MLLGGEEPGH TQWWFLLSGQ QQQQLQATTC G--GGPPGGG YPQQAMKGPP ------LLLL KSSQQCLGFD QNEELHHTYC CCCCTVPTTC G--GGPPGGG YPLLAMKGPP ---------- ---------- ---------- ------ATTC G--GGPPGGG YPLLAMKGPP TNNNVPCCPP PAARRSLVLQ HMGGAAAAVE EEEETAGKKC CAAGGPPGGG YPLLAMEGPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MAAC G--GGPPGGG YPLLAMKGPP ---------- ---------- -MTTVLLDHG GGGGVNS--N GKKGGPPGGG YPIISMSGPP ---------- ---------- -MTTVLLQHA AAAAVSNNNQ GKKGGPPGGG YPLLAMSGPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R MVVGGPPGGG YPLLAMSGPP ---------- ---------- ---------- ----MAGAAC CAAGGPPGGG YPLLAMEGPP ---------- ---------- ---------- -----SGLLC H--GGPPGGG YPAAAIKGPP ---------- ---------- ---------- -----PPLLC H--GGPPGGG YPAAAIKGPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MME SKKGGPPGGG YPLLAVRGPP ---------- ---------- ---------- ---------- ---------- -----MRGPP ---------- ---------- ---------- ---------- ---MMPPGGG L---ILILDD ---------- -MMKKREFG- --------AL LLLLAGAMML PAAAADDEEE TSPPMPKTGG ---------- -MMKKFIVSG PMFFALLRAL LLLLVGALLA PVVAADDEEE TSPPMKKTGG PPPELVVAAA YGGTINNFFF FIAAVVPPSE YKKIHHVVEE ELLPPYDDEH HFGGWNNSSA PPPEIVVAAA YGGTVNNFFF FLAAVVPPSP YKKVYYLLDD DLLPPYDDEH HFGGWNNSSA PPAEFTTLLL SDDF---AAA ALAAVVPPSS YKKIHHVVTT TMMPPNDDEH HFGGWNNSSS PPAEFTTLLL SDDF---AAA ALAAVVPPSP YQQIHHVVTT TMMPPNDDEH HFGGWNNSSA PPVELTTLLL SDDA---GGG GLAAVVPPSE FQQIHHLLII IMMPPNDDEH HFGGWNNSSA PPPEIVVAAA DEER---AAA AIAAVVPPSP YSSIGGVVAA AMMPPHDDEH HFGGWNNSSC PPAELVVVVV NMMAG--AAA AMCCVVSSSS FQQVGGTTDD DMMPPYGGEH HFGGWNNSSM PPRELVVAAA DGGR---AAA ALGGVLPPSG YQQIGGVVEE EMMPPNDDEH HFGGWNNAAA PPREILLPPP YNNTTEEYYY YLAATVPPSP YQQVHHLLPP PMMPPYDDEH HSGGWNNSSC PPREILLPPP YNNTIEEYYY YLAATVPPSP YQQVHHLLPP PMMPPHDDEH HSGGWNNSSC PPREILLPPP YNNTIEEYYY YLAATIPPSP YQQVHHLLPP PMMPPNDDEH HSGGWNNSSC PPREILLPPP YNNTIEEYYY YLAATVPPSP YQQVHHLLPP PMMPPHDDEH HSGGWNNSSC PPREILLPPP YNNTTEEYYY YLAATVPPSP YQQVHHLLPP PMMPPNDDEH HSGGWNNSSC PPREILLPPP YNNTTEEYYY YLAATVPPSP YQQVEE---- ---------- ---------- ---------- ----TEEYYY YLAATVPPSP YQQVHHLLPP PMMPPNDDEH HSGGWNNSSC PPREILLPPP YNNTTEEYYY YLAATVPPSP YQQVHHLLPP PMMPPNDDEH HSGGWNNSSC PPREILLPPP YNNTTEEYYY YLAATVPPSP YQQVHHLLPP PMMPPYDDEH HSGGWNNSSC PPREILLPPP YNNTTEEYYY YLAATVPPSP YQQVHHLLPP PMMPPNDDEH HSGGWNNSSC PPREILLPPP YNNTTEEYYY YLAATVPPSP YQQVHHLLPP PMMPPNDDEH HSGGWNNSSC PPRELVVTTT YGGTINNYYY YLAATLPPSP YQQVHHLLPP PVVIIHDDKH HSGGWNNSSC ---------- ---------- ---------- ---------- -MMPPNDDEH HSGGWNNSSC PPREILLPPP YSSTINNYYY YLAATVPPSP YQQVHHLLPP PMMPPNDDEH HSGGWNNSSC PPRELVVTTT YGGTIEEYYY YLAATVPPSP YKKVHHLLPP PVVPPYDDEH HTGGWNNSSC PPRELVVTTT YGGTIEEYYY YLAATLPPSP YKKVHHLLPP PVVPPYDDEH HTGGWNNSSC ---------- ---------- ---------- ---------- -MMPPFDDEH HSGGWNNSSC PPSELVVTTT YGGTIDDYYY YLAATVPPSP YSSVHHLLPP PMMPPFDDEH HSGGWNNSSC PPRELVVTTT YGGTINNYYY YLGGTVPPSP YQQVHHLLPP PVVTTHDDEH HSGGWNNSSC PPREVVVTTT ---NADDAAA AIFFTVPPSD FQQVSSVVDD DVVPPHDDEH HTGGWNNSSC PPREVVVTTT ---HRDDAAA AIFFTVPPSE FQQISSVVDD DVVPPNDDEH HTGGWNNSSC ---------- ---------- ---------- ---------- ---------- ---------- PPVELVVVVV QNNLEEEYYY YLAATVPPSP YQQVHHTTYY YTTNNSNNEH HSGGWNNSSC PPRELTTVVV QNNLEPPYYY YLSSTVPPSP YQQIHHTTFF FTTNNRDDEH HSGGWNNSSC DDDRLSSNNN HDDIQYYDDD DRKKNMGGVF GSSVKKGGPP PVVKKVDDKL LSQQPTTLLK GGQEFVVWWW GEEGGDDKKK KLVVTLPPSA RQQVNNVVSS SVVGGGNNEH HGGGFSS--- GGQEYVVWWW GEEGGDDKKK KLVVTAPPSP YKKVNNLLSS SVVGGGNNEH HSDDFTT--- C-PPNG-KPP ERRFLIIIIG GLSSYIDTTP PREPPKIVVV VIIEEVKKVS YSLHTVVVHH C-PPNA-KPP ERRYLIIIIA ALSSYIDTTK KRRPPAAIII IVVEEAVGRT YTYHTVVVHH S-PPLTGHAA ERRFLIIIIG GLSSYVDTTP PTQAARHIII IIIEDILAKT YSPHTVVVHH S-PPLAGHAA ERRYLIIIIG GLSSYIDTTP PTKAAKHIII IIIEEVFKKT YSPHTIIIHH S-PPLTGHAA ERRYLIIIIG GISSYIDVVP PLKAAKHIII IIIEEVFAKT YSPHTIIIHH C-PPNAPHPP ERRYLVVVVG GLSSYIDTTP PLKPPFAVVV VIIEELAERT YSPHTVVVHH C-PPNAPHPP ERRYLVVVVD DISSTIDTTP PTQPPKVVVV VIIDNLAERT YAPHTVVVHH C-PPYAPHPP ERRYLIIIIG GISSHIDTTP PREPPRVVVV VIIEELHRRT YSPHTIIIHH -----FGDSS SRNKLIIIIG GLSSYVDVVP PRAPPKHVVV VIIESIQAKC VSTHTSSSHH -----FGDSS SRDKLIIIIS SISSYVDVVP PRAPPKHVVV VIIENIHAKC LGLHTSSSHH -----FGDSS SRTKLMMMMC CLSSYVDVVP PRAPPKHVVV VIIEEIHAKC LGVHTSSSHH -----YGDII ARTKLVVVVA ALSSYVDVVP PRAPPKHVVV VIIEKIHTKC LGFHTSSSHH -----FGDSS SRTKLVVVVS SLSSYVDVVP PRAPPKHVVV VIIEEIHAKC LALHTSSSHH ---------- ---------- ---------- ---------- ----KIHAKC LALHTSSSHH -----FGDSS SRTKLVVVVS SLSSYVDVVP PRAPPKHVVV VIIEKIHAKC LALHTSSSHH -----FGDSS SRTKLVVVVS SLSSYVDVVP PRAPPKHVVV VIIEKIHAKC LALHTSSSHH -----FGDSS SRNKLVVVVS SFSSYVDVVP PRAPPKHVVV VIIEKIHEKC LGPHTSSSHH -----FGDSS SRTKLVVVVS SL-------- ---------- ---------- ---------- -----FGDSS SRTKLVVVVS SLSSYVDVVP PRAPPKHVVV VIIEKIHAKC LALHTSSSHH -----HGDPP KRRFLIIIIS SLSGYVDTTP PRTPPSHVVV VVVEEIAENI LGPHTSSSHH -----YGDAA VRNKLIIIIC CLSSYVDVVP PRAPPRHTTT TVVEYVFWKC LALHTSSSHH -----YGDSS VRNKLIIIIC CLSSYVDVVP PRAPPRHTTT TVVEYVFWKC LAPHTSSSHH -----HGDPP ERRFLIIIIS SLSGYVDTTP PRSPPSHVVV VVVDAIIQKT LAPHTSSSHH -----HGDPP QRRFLIIIIG GISGYVDTTP PRAPPSHVVV VVVEEISTKT LAPHTSSSHH -----HGDAA DRRYLVVVVS SLSGYADTTP PRAPPSYYYY YVVDKIAEKT LAPHTAAAHH -----HGDAA DRRYLVVVVS SLSGYADTTP PRAPPSYYYY YVVDKIADKT LAPHTAAAHH -----HGDPP SRRFLIIIIS SLSGYVDTTP PRAPPAHVVV VVVEEIAEKT LGPHTSSSHH -----HDKPP KRSHLIIIIC CLSDYINVV- -RKIIYETTT TIIESLHSLN LSPHTSSSHH -----HDKPP KRSHLIIIIC CLSDYVNVV- -REIIYQTTT TIIESLHALN LSPHTSSSHH ---------- ----MVVVVK KLSGGKFVV- ---------- ---------- ---------- FVPP-GGKEE TRDRLVVVVC CLSDFVDTTP PRAPPKAVVV VIIE-VLKGA CTPHTTTTHH YVDDESSKTT KRDRLVVVVS SLSDYIDVVP PRKPPEVTTT TIID-VLKSH VTPHTTTTHH ------GKRR GGPQMLLLLS SLGKYVTSSA AWDKKQY--- -----LIKFL LASHTAAADD ---------- DRRFFWWWWG GLTNFIDVVP PSNPPKHTTT TIID-VKDSG VVPHTFFFFF ---------- DRRYLWWWWG GLTSFVDVVP PARPPVSTTT TIIT-VEKSG VVPHTLLLYY HCGGPDYYYS S-EEEGG--E GGGLLDHYYE PLLGWWIIDG GGDDQQY--- ------LAAY HCGGPDYYYS S-DDDGGRRE GGGFLDHDDE PIIGWWVVYG GGPPQQY--- ------FAAY HCGGPEYYYS SGDDDGGTTD GPGFMDCEED VLLGWWIIDG GGPPQQD--- ------KHHY HCGGPDYYYS SGDDDGGTTN GPGFMDCEEE VLLGWWIIDG GGPPQQT--- ------LHHY HCGGPEYYYS SGDDDGGTTD GPGFLDCEEE ILLGYYMMDG GGEEQQT--- ------KHHY HCGGPGYYYT T-EEEGG--K GGGALDAQQE PLLGWWVVEG GGPPQQY--- ------FAAY HCGGPDYYYS S-EEEGG--E GGGFLDHDDE VLLGWWIIDG GGDDQQY--- ------LHHY HCGGPDYYYS S-EEEGG--D GGGFMDHEED PLLGWWVVEG GGPPQQQ--- ------LAAY HCLLASVVVV V-LLLQQGGN GGSVLDGEEE VKKGWWKKPG GGAASSP--- ------MGGY HCLLASVVVI I-PPPQQGGN GGGVLDGEEE VKKGWWKKPG GGEEAAP--- ------MGGY HCLLASVVVI I-SSSKKGGN GGGVLDGEEE VKKGWWQQPG GGAAAAP--- ------MGGY HCLLPSVVVV V-PPPEEGGN GGGVLDGKKE VKKGWWQQPG GGAAAAP--- ------LGGY HCLLASVVVI I-VVVKKGGN GGGVLDGEEE VKKGWWRRPG GGAAAAP--- ------SGGY HCLLASVVVI I-VVVKKGGN GGGVLDGEEE VKKGWWRRPG GGAAAAP--- ------LGGY HCLLASVVVI I-VVVKKGGN GGGVLDGEEE VKKGWWRRPG GGAAAAP--- ------LGGY HCLLASVVVI I-VVVKKGGN GGGVLDGEEE VKKGWWRRPG GGAAAAP--- ------LGGY HCLLPTVVVI I-PPPKKGGN GGGVLDGEEE VKKGWWRRPG GGSSAAP--- ------MGGY ---------- ---------- ---------- ---------- ---------- ---------- HCLLASVVVI I-VVVKKGGN GDGLLLP--E CSSG------ ---------- ---------- HCLLASIIII I-KKKEEGGN AGNFLLDSSN VKKGGGNNRF FFPPIIS--- ------KEER HCLLGCIIII I-PPPYYGGN GGGVLDGEEE VKKGWWAAEE EEAAAAP--- ------FGGY HCLLGCIIII I-PPPCCGGN GGGVLDGEEE VKKGWWVVEE EESSAAQ--- ------FGGY HCLLASLLLI I-KKKDDGGN AGNFLLDSSN VKKGWWKKPH HHSSPPL--- ------FGGY HCLLASIIII I-KKKDDGGN AGNFLLDSSN VKKGWWKKPH HHSSPPL--- ------FGGY HCLLASIIIV V-EEEEEGGN AGNFLLDSSN IKKNWWKKPH HHSSPPL--- ------FGGY HCRRT-IIIV V-EEEEEGGN AGNLLLDSSN IKKNWWKKPI IISSPPL--- ------YGGY HCLLASIIII I-KKKEEGGN AGNFLLDSSN VKKGWWKKPH HHSSPPL--- ------FGGY HCLLADIIII I-AAANNGGT PGNLLDGKKE PKKGWWAADK KKTTVVP--- ------FNNY HCLLADIIII I-AAADDGGS PGNLLDGKKE PKKGWWAADK KKVVVVP--- ------FNNY ---------- ---------- ---------- ---------- ---------- ---------- HCLLPNIIII I-AAAEEGGN AG-FEFDKKE LVVGWWRRGR RRKKAAL--- ------CGGY HCLLANIIII I-AAAEEGGY AG-FLFDSSN CIIGWWKKGK KKKKAAL--- ------CGGY DYQQPNLLLQ Q-SSSLLSSV PLNITSKHHG LSSAGGAASF FFEEEEI--- ------LQQL FALLPGMMMT T-DDDDDHHG GTAVYNDDDY VAATWWPPTD DDDDMMQAAV VGGGDAYGGY YALLPGLLLT T-KKKDDHHG GTAVYTNAAY VAATWWPPTG GGDDLLRAKT TGGG-AYDDY YWNNELVSSE EWWAVV--II ED-LLKDDRY YNIFFLRRRR KRIHLLLLEE ENRM------ YWSSGMITTE EWWTVV--FF EE-FLKEEAY YNLVVLAAAR RHLYIIILQQ QHRM------ YWRRDMVSSE EWWALL--FF EN-IPLAAKY YHLFFLRRRR RNVQIIILAA AHQM------ YWRRDMVTTE EWWALL--FF EN-IPLSSKY YHLFFLRRRR RNVQIIILAA AHQM------ YWRRDMVSSE EWWGLL--FF EN-IPLSSKY YHIFFLRRRR KNVQIIILAA AHQM------ YWYYDLVTTE EWWGTT--VV ED-LPLGGRY YRLFFLTTTR RHLQIIIFDD DHQL------ YWYYDLLTTE EWWGTT--VV ES-VGLAAKY YHLVVLYYYR RHLQLLLLAA AYQM------ YWYYDMVTTE EWWGTT--II EG-LPLNNGY YRLIILRRRR RHLQLLLVEE EHQM------ YYHHNMVSSE EWWAAA--FF KDFNAA--LY YSIVVWQQQH EIIQLLLM-- -DGL------ YYHHNMVSSE EWWAAA--FF KDFNAA--LY YSIVVWQQQH EIIQLLLM-- -DGL------ YYHHNMISSE EWWAAA--FF RDFNAA--LY YSLVVWQQQH EIIQLLLL-- -DGL------ YYHHNMISSE EWWAAA--LL RDFNAA--LY YSLVVWQQQR EIVQLLLL-- -DGL------ YYHHNMISSE EWWAAA--LL RDFNAA--LY YSLVVWQQQH EIVQLLLL-- -DGL------ YYHHNMISSE EWWAAA--LL RDFNAA--LY YSLVVWQQQH EIVQLLLL-- -DGL------ YYHHNMISSE EWWAAA--LL RDFNAA--LY YSLVVWQQQH EIVQLLLL-- -DGL------ YYHHNMISSE EWWAAA--LL RDFNAA--LY YSLVVWQQQH EIVQLLLL-- -DGL------ YYHHNMISSE EWWAAA--VV QNFNAA--LY YKLVVWQQQH EIVQLLLM-- -DGH------ ---------- ---------- ---------- ---------- ---------- ---------- ---------I ISSAHH--RR LTSRYA--RV VGT------- ---------- ---------- RYWWGFWSSI IQQCCC--YY TTAEMA--GV VVSLLYIIIR VIDELLLL-- -DQANNNPII YYHHNMISSE EWWGAA--FF ALFKEA--MY YHLVVWTTTH RRIQIIILEE EDGL------ YYHHNMISSE EWWGAA--FF ALFKEA--HY YHLVVWTTTH RLVQIIILKK KDGL------ YYHHNMISSS SWWGAA--FF TKFDQD--LY YRLCCLAAAG ELRQLLLLNN NTGL------ YYHHNMISSS SWWGAA--FF LQFNQD--LY YRLVVWPPPG EIKQLLLLDD DKGL------ YYHHKMISSS SWWGAA--FF SKFDQD--LY YSLVVWPPPG EMKQIIILEE ETGL------ YYHHKMISSS SWWGAA--FF SKFNQD--LY YSLVVWPPPG EIKQIIILPP PTGL------ YYHHKMISSS SWWGAA--FF RTFDQD--LY YRLVVWPPPG ELKQLLLLSS STGL------ YYRRNMISSE EWWGSS--II KKFNAE--LY YNVIIWDDDK KYLQIIILQQ QLGA------ YYRRNMISSE EWWGSS--II KKFNAE--LY YNVIIWDDDK KHLQIIILMM MRGA------ -------SSL LRRGGG--VV CREEKE--LV VKKVV----- ---------- ---------- YYFFNMVAAE EWWGAA--FF RRYHTDRRQY YCLFFWQQQR ELFQIIILDD DDGL------ YYFFDMVSSE EWWGAA--WW RRWKVDMMQY YCLFFWSSSQ TLYQIIILSS SDGI------ LNRRESESSR RPPDEE--AA FESEFTGGLK KQVEE----- ---------- ---------- YAKKNMLTTS SFFTGGYYMM DFQMQAMMRF FNIQQLHHHR QPKKFFFVGG GP-------- YAKKNLVTTS SFFTGGYYMM DFKMAAMMHF FNVTTLHHHK QPKKFFFVGG GP-------- ELLRPLLDDP TKKLMMGMMV VKDLLLLSIW WW-EEEDGKN EKKVIIIIEE AEEGNNPEII EVVRPLLDDP TKKLMMGVVV VKDLLLLSIW WW-EEEDGKQ ERRVIIIIDD AEEGPPPPVV EVVRPAADDP VRREYYGVVV VTNLLLLSIW WW-EEEGGKH KKKTAAAATT ATTAEEPPLL EVVRPAADDP VRREYYGVVV VTNLLLLSIW WW-EEEGGKH EKKTAAAATT PPPKKKPPLL EIIRPAADDP SKKDYYGVVV VTNLLLLAIF WWKDDDDGTE KKKTIIIITT PDDADDPDLL ELLRPAADDP TKKAYYGCCV VKDLLLLSIW WW-DDDKDKA RKKVIIIIEE ADDPQQPPVV ELLRPAADDP TKKAYYGCCV VKDLLLLSIW WW-DDDNGSH KKKVIIIIDD ASSEQQPPII ELLRPAADDP ARRTYYGVVV VEDLLLLSVW WW-QQQNGSG RKKVIIIIEE AEEPQQPPLL EIIRFLLDDP SAATQQGCCA ANIQQQQYKN EE-------- ----TTTTWW EQQVSSKVKK EIIRFLLDDP DAATQQGCCA ANIQQQQYKN GG-------- ----TTTTWW EQQVSSKVKK EIIRFLLNNP DAAAQQGCCA ATIQQQQYKN GG-------- ----TTTTWW EQQVPPKVKK EIIRFLLNNP DAAAQQGCCA ATIQQQQFKN DD-------- ----TTTTWW QQQVPPKVKK EIIRFLLNNP DAAAQQGCCA ATIQQQQYKN GG-------- ----TTTTWW EQQVPPKVKK EIIRFLLNNP DAAAQQGCCA ATIQQQQYKN GG-------- ----TTTTWW EQQVPPKVKK EIIRFLLNNP DAAAQQGCCA ATIQQQQYKN GG-------- ----TTTTWW EQQVPPKVKK EIIRFLLNNP DAAAQQGCCA ATIQQQQYKN GG-------- ----TTTTWW EQQVPPKVKK EIIRFLLDDP AAASQQGCCA ATIQQQQYKN GG-------- ----TTTTWW EEEVPPKVKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CLLRSIIWWK NIINQQDVVE ESGRRRRSDP AA-------- ----AAAAVV KDDLYYVVAA EIIRFLLDDP DAAAQQGCCA ATVFFFFYKE DD-------- ----KKKKWW EKKVSSKVEE EIIRFLLNNP DAADQQGCCA ASIFFFFYKE DD-------- ----KKKKWW EQQVSSKVEE EIIRFLLDDP AKKDTTGSSA ANMIIIIFKT DD-------- ----SSSSWW EPPVPPKVQQ EIIRFLLDDP AKKDTTGSSA ANMIIIIFKT DD-------- ----SSSSWW ESSVPPKVQQ EIIRFLLDDP SKKDTTGSSA ANMIIIIFKN DD-------- ----TTTTWW ESSVPPKVEE EIIRFLLDDP SKKDTTGSSA ANMIIIIFKN DD-------- ----TTTTWW ESSVPPKVEE EVVRFLLDDP SKKDTTGCCA ANMVVVVFKT DD-------- ----SSSSWW ESSIPPKVRR EVVRFLLEEP TSSEHHACCA AGIFFFFHPV EE-------- -TT-TTTTHH TFFISSKVSS EVVRFLLEEP TSSEHHACCA AAIFFFFHPD KK-------- -KK-VVVVQQ STTISSKVEE ---------- ---------- ---------- ---------- ---------- ---------- EIIRFLLNNP REENQQGCCA AXXXXXXX-- ---------- ---------- ------QGEE EIIRFLLNNP KKKAEEGCCA AKVFFFFKKK DD-------- -EEFEEEEAA VPPGLLDTGG ---------- ---------- ---------- ---------- ---------- ---------- EIIRFPPGGS NAANYYATTA AQLWWWWYED AA-------- ---------- -EEWAAAVAA EIIRCAAGGE AHHNYYCTTA AQLWWWWYED EE-------- ---------- -EEWAAAVAA LKKKAAPLLT DIISSDDDDD KFLLYYSWII IEERRRDINP FKKPPLLGVV VLLLLGIFFF LKKKMMPLLT DIISSDDDDD RFLLYYSWLL LEERRRDINP HQQPPLLGVV VIIIIGLYYY LQQQAAPLLT DIISSDDDDD RFLLYYSWTT TEERRRDVDP HNNPPLLGVV VIIIIGIAAA LQQQAAPLLT DIISSDDDDD RFLLYYSWTT TEERRRDVDP RKKPPLLGVV VIIIIGIAAA LKKKAAPLLT DIISSDDDDD KYLLYYAWLL LEEHHHDVDP MNNPPLLGVV VIIIIGIVVV LKKKAAPLLT DIISSDDDDD RFLLYYSWTT TDDLLLDVDP FEEPPLLGVV VIIIIGIVVV LKKKAAPLLT DIISSDDDDD RFLLYYSWTT TEEHHHDVDP FNNPPLLGVV VIIIIGIVVV LKKKAAPLLT DIISSDDDDD RFLLYYSWTT TEERRRDVDP FNNPPHHGVV VLLLLGIVVV GWWWEEPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDINP QKKPPLLGII ILLLLGSIII GWWWEEPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDINP KKKPPLLGII ILLLLGSIII GWWWEEPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDIDP QRRPPLLGLL LLLLLGSIII GWWWEEPLLT DIISSDDDDD HFLLYYSWHH HDDRRRDVDP QRRPPLLGLL LLLLLGSIII GWWWEEPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDIDP QRRPPLLGLL LLLLLGSIII GWWWEEPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDIDP QRRPPLL--- ---------- GWWWEEPLLT ---------- ---------- ---------- ---------- ---------- GWWWEEPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDIDP QRRPPLLGLL LLLLLGSIII GWWWEEPLLT DIISSDDDDD RFLLYYNWHH HDDRRRDIDP KRRPPLLGII ILLLLGSIII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KFFFSSSEEP PAAFFSSSSD LLIIIIL--- ---------- ---------- ---------- GWWWEEPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDIDP RNNPPLLGII ILLLLGSIII GWWWEEPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDIDT RNNPPLLGII ILLLLGSIII NWWWEEPLLT DFFSSDDDDD RFLLYYVWHH HDDRRRNIDL KNNPPLLGLL LVVVVGLIII NWWWEEPLLT DFFSSDDDDD RFLLYYVWHH HDDRRRNIDV KNNPPLLGVV VAAAAGLIII NWWWEEPLLT DFFSSDDDDD RFLLYYVWHH HDDRRRNIDP KNNPPLLGII IVVVVGLLLL NWWWEEPLLT DFFSSDDDDD RFIIYYVWHH HDDRRRNIDP KNNPPLLGII IVVVVGLLLL NWWWEEPLLT DFFSSDDDDD RYLLYYVWHH HDDRRRNIDP AKKPPLLGVV VAAAAGLLLL GWWWEEPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDIDP LKKVVLLSVV VIIIIGSVVV NWWWDDPLLT DIISSDDDDD RFLLYYSWHH HDDRRRDIDP KNNPPLLSVV VIIIIGSIII ---------- ---------- ---------- ---------- ---------- ---------- NGGGMMGMMT DIISSDDDDD RYLLYYSWHH HDDRRRDIDR ANNPPLLGVV VLLLLGAIII SGGGDDGMMS DIISSDDDDD RFLLYYNWHH HDDRRRDIDP ENNPPLLGLL LLLLLGAIII ---------- ---------- ---------- ---------- ---------- ---------- DIIIAAILLV DIIAADDDDD QTLLWWNFDD DKKRRRDIDP HKKPPQQYKK KIIIIDQVVV DIIIAAVLLV DIISSDDDDD SRLLWWNFDD DKKRRRDIDP HHHPPQQYKK KIIIIGQVVV RAAD------ ---------- GHKKKKKTTG PPQLLIISGG GRRVVYYSSY TTWDDQPGGL REEP------ ---------- GAEEEEETTG PPQIIVVSGG GRRVVYYSSY SSWNNQPGGL RAAP------ ---------- GRTTTTTAAG PPQVVIISGG GRRVVYYSSY TTWDDQPGGV RTTP------ ---------- GKAAAAAAAA PPQVVIISGG GRRVVYYSSY TTWDDQPGGV KTTP------ ---------- GKTTTTTGGY PPQVVIISGG GKRVVYYSSY TTWDDQPDDR RAAT------ --------AA NGAAAAANNG PPQVVIISGG GRRVVYYSSY AAVDDQPGGI RAAG------ --------AA SAEEEEENNG PPQVVIISGG GRRVVYYSSY AAWDDQPGGI KAAA------ ---------- SGPPPPPNNG PPQVVVVSGG GRRVVYYSSY SSWDDQPGGI RGGGV-QQTT CPPEPPPLVV GKRRRRRPPG PPQIILLSGG GKRLLYYSSY DDWDDQ-DDL KGGGV-QQTT CPPEPPPLVV GKRRRRRPPG PPQIILLSGG GKRLLYYSSY AAWDDQ-NNL KGGGV-QQKK SPPEPPPLVV GKKKKKKPPG PPQIILLSGG GKRLLYYSSY AAWDDQ-DDL KDDGV-QQDD SPPEPPPLVV GKQQQQQAAG PPQIILLSGG GKRLLYYSSY AAWDDQ-DDL KGGGV-QQKK SPPEPPPLVV GKRRRRRAAG PPQIILLSGG GKRLLYYSSY AAWDDQ-DDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KGGGV-EEKK SPPEPPPLVV GKRRRRRAAG PPQIILLSGG GKRLLYYSSY AAWDDQ-DDL KGGGV-QQKK SPPEPPPLVV GKRRRRRPPG PPQIILLSGG GKRIIYYSSY DDWDDQ-DDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RGGGV-KKEE CPPDPPPVVV GKKKKKKPPG PPQIILLSGG GKRLLYYSSY KKWDDQ-DDM RGGGV-KKEE CPPDPPPVVV GKIIIIIPPG PPQIILLSGG GKRIIYYSSY IIWDDQ-DDL KGGSA-DDTT WSSDVVVPII GQKKKKKRRG PPQIILLTGG GKRLLYYSSF AAWDDQ-GGL KGGSA-DDTT WSSDVVVPII GKKKKKKRRG PPQIILLSGG GKRLLYYSSF AAWDDQ-KKL KGGSA-DDSS FFFDVVVPII GKSSSSSRRG PPQIILLSGG GKRLLYYSSF AAWDDQ-EEL KGGSA-DDTT FFFEVVVPII GKSSSSSRRG PPQIILLSGG GKRLLYYSSF AAWVVS-EEI KGGSY-DDEE EYYSVVVPVV GHRRRRRRRG PPQIILLSGG GKRIIYYSSF RRWDDQGDDL TEESV-EE-- -IIEAAALVV GRKKKKKEEG PPQLLLLSGG GKRLLYYSSY KKWDDQ-EEH SEETV-DD-- -IIPAAALVV GRQQQQQEEG PPQLLLLSGG GKRLLYYSSY KKWDDQ-EEN ---------- ---------- ---------G PPAIILLSGG GKRLLYYSSY TTWDDQ-NNV RDDAV-PPKK EPPEPPPVLL GRRRRRRLLG PPQLLLLSGG GRRLLYYSSF PPWDDQ-EEM SDDLIEKKKK EPPPAAARVV GRRRRRREEG PPQLLLLSGG GKRLLYYSSY PPWDDQ-KKM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---VVQQSGG GKRVVYYSSL NNWDD----- ---------- ---------- ---------- ---VVSSSGG GQRLLYYSSL NNWDD----- KKKKMVKLN- --PPPGGLEE EIKKEFFFDG EE-----AHQ RSSSGGASSD DYY------- RRRRMAKVN- --PPPGGLEE ELKKEFFFDG RR-----AHQ RWWWGGASTD DFF------- PPPPQVLAG- --PPPGGLTT TLDDDYWWEP DDGGG--YHQ REEEGGCSTD DFFSSSSVKK PPPPEVMAG- --GGGGGLEE ELKKDYFFSP DDGGG--YHQ REEEGGCSTD DFFSSSSV-- GGGGMVMAG- --EEEGGLTT TLKKDFWWDP AAGGG--YHQ REEEGGCSTD DFFSSSSV-- DDDDMVKLG- --PPPGGIEE EFPPKFFFEP KKGGG--HHQ RQQQGGCSSD DYY------- KKKKMVKVN- --PPPGGMQQ QFPPNFFFDG EE-----QHQ RQQQGGASSD DYY------- RRRRIAKAD- --PPPGGLSS SLPPGFFFEG DDGGG--LHQ REEEGGSSSD DYYSSSS--- IIIIGSVMVD DVVVVGGLKK KLPPNFLLDG KKEEEPGAHE RPPPGGCSSD DWW------- IIIIGSVMID DVAAAGGLKK KLPPNFLLDG KKEEEPGAHE RPPPGGCSSD DWW------- IIIIGSVMID DVVVVGGLKK KLPPNFLLDG KKEEEPGAHE RPPPGGCSSD DWW------- IIIIGSVMID DVVVVGGLTT TLPPNFLLDG KKEEEPGAHE RPPPGGCSSD DWW------- IIIIGSVMVD DVVVVGGLKK KLPPNFLLDG KKEEEPGAHE RPPPGGCSSD DWW------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIIIGSVMVD DVVVVGGLKK KLPPNFLLDG KKEEEPGAHE RPPPGGCSSD DWW------- IIIIGSVMID DVVVVGGLKK KLPPNFLLDG KKEEEPGAHE RPPPGGCTSD DWW------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIIIGSVMID DVEEEGGLKK KLPPNFLLDG KKEEEPGVHE RPPPGGCSSD DWW------- LLLLGAVMID DVKKKGGLKK KLPPNFLLDG KKEEEPGVHE RPPPGGCTSD DWW------- VVVVGSHIID DVEEEGGLKK KIPPNFFFDG AAEEEPGAHE RPPPGGCTSD DWW------- VVVVGSHIID DVEEEGGLKK KIPPNFFFDG AAEEEPGSHE RPPPGGCTSD DWW------- MMMMGSHIID DVEEEGGLSS SIPPNFFFDG DDEEEPGAHE RPPPGGCTSD DWW------- MMMMGSHIID DGEEEGGLTT TIPPDFFFDG DDEEEPGSHE RPPPGGCTSD DWW------- VVVVGSHMID DVEEEGGLSS SIPPNFFFDG AAEEEPGSHE RPPPGGCTSD DWW------- VVVVGATMVN NIEEEGKMEE EIRRDFLLDG KKIIIEGYHE RPPPGGCTSD DWW------- VVVVGATMID DVIIIGHMVV VIKKNFLLDG KKVVVPGYHE RPPPGGCTSD DWW------- VVVVGSVMID DVEEEGGLTT TVKKNFLLDG KKEEEPGCHD RPPPCCSTSD DLL------- VVVVGGTILD DIEEEGGMKK KLEENFLLDG GGEEEPGGHE R--------- ---------- VVVVGGHIID DVVVVGGISS SLEEDFLLDA NNEEEPGSHE RPPPGGCTSD DWWDDDDA-- ---------- ---------- ---------- ---------- ---------- ---------- ----GKDDYL LKNNNDGKEE ELEEDFAADY EELLLGG-HI RGGGSSLYSS S--------- ----GKDDFL LKYYYDGKEE ELEEQFAADY AAEEEKG-HQ RGGGAALYAG GAANNNNRLL ------- ------- KRR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LVVQARV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MAKAAAKKKQ QQETPPCCRT TPTGLTAARR LAADDAMQSL TTLLTPGGKA EAAAAAWWTT gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- GRRRSSAAPP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSIQLASPPR RSEEKGRKRS SSPGGGLLLV SSAKVVVVVP PAAAAVWWAW LLPGKHGAAL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --ARAEGAAL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------G LLGEEPGHHQ ---------- ---------- ---------- ---------- ------LLLN SSQCLGFDDN ---------- ---------- ---------- ---------- ---------- ---------- PPLNRTTPPH HPNNLAPAPP PPPRRRVVVP RRPYTTTIIN NPRRRLCCPH AARSLVLQQM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M ---------- ---------- ---------- ---------- ---------- ---------M ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMKREFG--- ---------- ---------- ---------- ---------- ---------- MMKFIVSGGM ---------- ----AAAVVF FFFRPTFYPM AAKKPEDLYA ACLTTGADDF FIVVDVPKSS ---------- -------AAL LLLPPTFYPD AARRPEDIYA AALVVGPDDF FLVVDVPKSS ---------- -------MMM MMMPPTFHPL AAQQPEEFYL LLLPPDPDDA ALVIDVPGSS ---------- -------MMM MMMPPTFHPL AAEEPENFYL LLLPPDPDDA ALVIDVPGSS ---------- -------MML LLLPPTFYAL AAEEPEKLFL LMLPPDPDDG GLVVDVPTSS ---------- -------AAW WWWPPSFYPL AAKKPETIYA AMFPPEPDDA AIVVDVPASS ---------- -------VVW WWWPPTFYPM AAKKPEKLYV VRLPPMPDDA AMVVDVSQSS ---------- -------AAW WWWPPTFYPM AAQQPERLYA ALLPPGPDDA ALVLDLPDSS ---------- -AAAKKKTT- ---CPGYPLA MM--PEEIYP PCIRRNPDDY YLTVDVPKSS ---------- ---------- ---------- ----PEEIYP PCIRRNPDDY YLTVDVPKSS RRGGGLGGGA ASSSQQQGG- ---CPGYPLA MM--PEEIYP PCIGGNPDDY YLTVDIPKSS ---------- ---------- ---------- MM--PEEIYP PCIRRNPDDY YLTVDVPKSS ---------- -AAAKKKGG- ---CPGYSLA MM--PEEIYP PCIRRNPDDY YLTVDVPKSS QQPPPRIIIS SAAAKKKGG- ---CPGYSLA MM--PEEIYP PCIRRNPDDY YLTVDVPKSS ---------- -AAAKKKGG- ---CPGYSLA MM-------- ------PDDY YLTVDVPKSS ---------- -AAAKKKGG- ---CPGYSLA MM--PEEIYP PCIRRNPDDY YLTVDVPKSS SSGGGLQQQD DAAAKKKGG- ---CPGYPQA MM--PEEIYP PCIRRNPDDY YLTVDVPKSS TTYYYTVVVT TPPPKKKGG- ---CPGYSLA MM--PEEIYP PCIRRNPDDY YLTVDVPKSS ---------- -AAAKKKGG- ---CPGYSLA MM--PEEIYP PCIRRNPDDY YLTVDVPKSS AAVVVTAAAA AGGGTTTCCT TTTKPGYALA MMKKPEKLYT TCVNNGLDDY YLTVDLPSSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMMKKKGG- ---CPGYKLA MM--PEEIYP PCIRRSPDDY YLTVDVPKSS DDHHHVNNNK KSSSVVVGGC CCCSPGYAIS MM--PESLYT TAVAAGPDDY YLTVDVPSSS QQHHHVSSSK KNNNQQQGGC CCCSPGYALA MM--PETLYT TAVAAGPDDY YLTVDLPNSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMQ QQQGPGYALA MM--PEKLYT TAVTTGPDDY YLTVDVPSSS -----MAAAA AGGGAAACCG GGGTPGYALA MMKKPEKLYT TCVNNGPDDY YLTVDVPNSS ------SSSN NGGGKKKHH- ----PGYAAA II--PEEVFT TAP---PDDA AITVDVPESS ------PPP- -PPPKKKHH- ----PGYAAA II--PEEVFT TAP---PDDA AITVNVPESS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----SSSSSC CCCCPGYALA VVNNPEKLYV VCVPPNGDDY YLTVDVPASS ---------- ---------- ---------- MMSSPEKLYV VTVPPNGDDY YLTVDVPESS ---------- ---------- ----PGLI-I LLSSDRFLFN NWLGGDITTD DRNPRMGQVV --AAAAGGGA AAAAGGGPPR RRRFDETCPM PPIIGEEFYW WTLVVEQDDK KLTIDLPGSS RRAAAVGGGA AAAAAAAPPG GGGRDETCPM KKIIGEDYYW WTLAAEQDDK KLTVDAPKSS EEEETSVVVV LPPPPYYDLF FFFFFGWWNS SALLC--N-- PPNNNNRFVP PPGGGRRSSS PPPPTGILLL LPPPPYYDLF FFFFFGWWNS SAYYC--N-- PPFFFFRYVP PPAAARRSSS SSSSTGVVVV MPPPPNNDFF FFFFFGWWNS SSLLS--LGG AAFFFFRFIP PPGGGRRSSS PPPPTGVVVV MPPPPNNDFF FFFFFGWWNS SALLS--LGG AAFFFFRYIP PPGGGRRSSS EEEEKGVLLL MPPPPNNDFF FFFFFGWWNS SALLS--LGG AAFFFFRYIP PPGGGRRSSS PPPPRAVVVV MPPPPHHDLF FFFFFGWWNS SCLLC--NPP PPHHHHRYVP PPGGGRRSSS SSSSTGVTTT MPPPPYYGLF FFFFFGWWNS SMLLC--NPP PPHHHHRYVP PPDDDRRSSS GGGGTAVVVV MPPPPNNDLF FFFFFGWWNS SALLC--YPP PPHHHHRYVP PPGGGRRSSS PPPPQSILLL MPPPPYYDLS SSSSSGWWNS SC------GG SSTTTTNKLP PPGGGMMSSS PPPPHSILLL MPPPPHHDLS SSSSSGWWNS SC------GG SSTTTTDKLP PPSSSIISSS PPPPQCILLL MPPPPNNDLS SSSSSGWWNS SC------GG SSTTTTTKLP PPCCCMMSSS PPPPQCILLL MPPPPHHDLS SSSSSGWWNS SC------GG IITTTTTKLP PPAAAIISSS PPPPQCILLL MPPPPNNDLS SSSSSGWWNS SC------GG SSTTTTTKLP PPSSSIISSS PPPPQCI--- ---------- ---------- ---------- ---------- ---------- PPPPQCILLL MPPPPNNDLS SSSSSGWWNS SC------GG SSTTTTTKLP PPSSSIISSS PPPPQCILLL MPPPPNNDLS SSSSSGWWNS SC------GG SSTTTTTKLP PPSSSIISSS PPPPQSILLL MPPPPYYDLS SSSSSGWWNS SC------GG SSTTTTNKLP PPSSSIISSS PPPPQCILLL MPPPPNNDLS SSSSSGWWNS SC------GG SSTTTTTKLP PPSSS----- PPPPQCILLL MPPPPNNDLS SSSSSGWWNS SC------GG SSTTTTTKLP PPSSSIISSS PPPPTSILLL VIIIIHHDLS SSSSSGWWNS SC------GG PPSSSSRFLP PPSSSLLSSG ---------- MPPPPNNDLS SSSSSGWWNS SC------GG AASSSSNKLP PPCCCIISSS PPPPSSILLL MPPPPNNDLS SSSSSGWWNS SC------GG SSSSSSNKLP PPCCCIISSS PPPPTSILLL VPPPPYYDLT TTTTTGWWNS SC------GG PPSSSSRFAP PPSSSVVSSG PPPPTSILLL VPPPPYYDLT TTTTTGWWNS SC------GG PPSSSSRFVP PPGGGVVSSG ---------- MPPPPFFDLS SSSSSGWWNS SC------GG AASSSSRYLP PPSSSIISSG PPPPSSILLL MPPPPFFDLS SSSSSGWWNS SC------GG AASSSSRYLP PPSSSIISSG PPPPTSILLL VTTTTHHDLS SSSSSGWWNS SC------GG PPSSSSRFLP PPSSSLLSSG DDDDTCIVVV VPPPPHHDVT TTTTTGWWNS SC------DD PPTTTTSHVP PPCCCNNSSD EEEETCIVVV VPPPPNNDVT TTTTTGWWNS SC------DD PPTTTTSHVP PPCCCNNSSD ---------- ---------- ---------- ---------- --------PR RRKKKSSSSG PPPPTCITTT TNNNNSSNLS SSSSSGWWNS SCHHFVV-GG EEVVVVDRLP PPCCCNNSSD PPPPTCVTTT TNNNNRRDLS SSSSSGWWNS SCYYYVVESS TTVVVVDRLP PPSSSNNSSD FFFFLGLGGG VKKKKVVDES SSSSSQPPTI IK------GG RRVVVVPQQL LLSSSDDGGK AAAATGIVVV VGGGGGGNAG GGGGGGFFS- ---------- ------RFTG GGGGGDDTTN PPPPQGVLLL VGGGGGGNAS SSSSSDFFT- ---------- ------RYAG GGGGGDDTTS SSSRRRIIDT TTPPPPREEP PKKIIIIKVV IIEPPVVSGG YYRLLHHCGG PPDAAIIISS SSSRRRIIDT TTPPPPRRRP PAAVAAAKII VVEPPARTGG YYKYYHHCGG PPDAAIIISS SSSRRRVVDT TTPPPPTQQA ARRIHHHKII IIEPPIKTGG YYRPPHHCGG PPEGGIIVSS SSSRRRIIDT TTPPPPTKKA AKKIHHHKII IIEPPVKTGG YYRPPHHCGG PPDGGIIVSS SSSRRRIIDV VV----LKKA AKKIHHHKII IIEPPVKTGG YYRPPHHCGG PPEGGIIVSS SSSRRRIIDT TTPPPPLKKP PFFLAAAKVV IIEPPLRTGG YYRPPHHCGG PPGGGIIVTT SSSHHHIIDT TTPPPPTQQP PKKVVVVKVV IIDPPLRTGG YYRPPHHCGG PPDGGIIISS SSSRRRIIDT TTPPPPREEP PRRIVVVKVV IIEPPLRTGG YYRPPHHCGG PPDGGVVVSS SSSRRRVVDV VVSSSSRAAP PKKLHHHKVV IIEAAIKCNN VVNTTHHCLL AASGGEEMVV SSSRRRVVDV VVSSSSRAAP PKKLHHHKVV IIEPPIKCNN LLNLLHHCLL AASGGEEMII SSSRRRVVDV VVSSSSRAAP PKKLHHHKVV IIEAAIKCGG LLYVVHHCLL AASGGEEMII SSSRRRVVDV VVTTTTRAAP PKKLHHHKVV IIEPPIKCNN LLFFFHHCLL PPSGGEEMVV SSSRRRVVDV VVSSSSRAAP PKKLHHHKVV IIEPPIKCEE LLFLLHHCLL AASGGEEMII ---------- ---------- ---------- ---PPIKCEE LLFLLHHCLL AASGGEEMII SSSRRRVVDV VVSSSSRAAP PKKLHHHKVV IIEPPIKCEE LLFLLHHCLL AASGGEEMII SSSRRRVVDV VVSSSSRAAP PKKLHHHKVV IIEPPIKCEE LLFLLHHCLL AASGGEEMII SSSRRRVVDV VVTTTTRAAP PKKLHHHKVV IIEAAIKCGG LLTPPHHCLL PPTGGEEMII ---------- ---------- ---------- ---------- ---------- ---------- SSSRRRVVDV VVSSSSRAAP PKKLHHHKVV IIEPPIKCEE LLFLLHHCLL AASGGEEMII GGGRRRVVDT TTTTTTRTTP PSSLHHHKVV VVESSINIGG LLFPPHHCLL AASGGDDMII SSSRRRVVDV VVTTTTRAAP PRRIHHHKTT VVEPPVKCGG LLNLLHHCLL GGCGGEEMII SSSRRRVVDV VVSSSSRAAP PRRIHHHKTT VVEPPVKCGG LLNPPHHCLL GGCGGEEMII GGGRRRVVDT TTTTTTRSSP PSSLHHHKVV VVDPPIKTGG LLYPPHHCLL AASGGEEMII GGGRRRVVDT TTTTTTRAAP PSSLHHHKVV VVEPPIKTGG LLYPPHHCLL AASGGEEMII GGGRRRAADT TTEEEERAAP PSSLYYYKYY VVDPPIKTGG LLYPPHHCLL AASGGEELVV GGGRRRAADT TTEEEERAAP PSSLYYYKYY VVDPPIKTGG LLFPPHHCRR TT-GGEELVV GGGRRRVVDT TTKKKKRAAP PAALHHHKVV VVEAAIKTGG LLFPPHHCLL AASGGEEMII DDDRRRIINV VVNNNNRKKI IYYLEEEHTT IIEPPLLN-- LLFPPHHCLL AADGGNNMII DDDRRRVVNV VVNNNNREEI IYYLQQQHTT IIEPPLLN-- LLFPPHHCLL AADGGNNMII GGGVVVKKFV VVGGGG---- ---------- ---------- ---------- ---------- DDDRRRVVDT TTTTTTRAAP PKKLAAAKVV IIEGGVGADD CCAPPHHCLL PPNGGNNMII DDDFFFIIDV VVTTTTRKKP PEEIVVVKTT IIDGGVSHNN VVAPPHHCLL AANGGNNMII KKKRRRVVTS SSYYYYWDDK KQQFYYYP-- -----LFLVV LLISSHDYQQ PPNTTAAKQQ NNNRRRIIDV VVSSSSSNNP PKKLHHHKTT IIDTTVSGGG VVGPPHFALL PPGSSMMITT SSSKKKVVDV VVSSSSARRP PVVLSSSKTT IITDDVSGGG VVGPPHYALL PPGRRMMITT SAALLNNGGG IILLLHYYSF FFEPLWIIDD DGDQQ----- ------AAAY DDFFWWNNL- SAALLGGGGG IILLLHDDTF FFEPIWVVYY YGPQQ----- ------AAAY DDFFWWNNL- STTLLGGPPG IIMMMCEETF FFDVLWIIDD DGPQQ----- ------HHHY DDFFWWNNL- STTLLGGPPG VVMMMCEETF FFEVLWIIDD DGPQQ----- ------HHHY DDFFWWNNL- STTLLGGPPG IILLLCEETF FFEILYMMDD DGEQQ----- ------HHHY DDFFWWNNL- TAALLNNGGG IILLLAQQSF FFEPLWVVEE EGPQQ----- ------AAAY DDGGWWHHL- SAALLSSGGG IILLLHDDNL LLEVLWIIDD DGDQQ----- ------HHHY DDFFWWHHL- SAALLSSGGG VVMMMHEESF FFDPLWVVEE EGPQQ----- ------AAAY DDFFWWHHL- VNNTTGGGGS FFLLLGEETF FFEVKWKKPP PGASS----- ------GGGY DDFFWWQQP- ISSSSGGGGG FFLLLGEETF FFEVKWKKPP PGEAA----- ------GGGY DDFFWWQQP- ISSTTGGGGG FFLLLGEETF FFEVKWQQPP PGAAA----- ------GGGY DDFFWWQQP- VSSTTGGGGG FFLLLGKKTF FFEVKWQQPP PGAAA----- ------GGGY DDFFWWQQP- ISSSSGGGGG FFLLLGEETF FFEVKWRRPP PGAAA----- ------GGGY DDFFWWQQP- ISSSSGGGGG FFLLLGEETF FFEVKWRRPP PGAAA----- ------GGGY DDFFWWQQP- ISSSSGGGGG FFLLLGEETF FFEVKWRRPP PGAAA----- ------GGGY DDFFWWQQP- ISSSSGGGGG FFLLLGEETF FFEVKWRRPP PGAAA----- ------GGGY DDFFWWQQP- ISSTTGGGGG FFLLLGEETF FFEVKWRRPP PGSAA----- ------GGGY DDFFWWQQP- ---------- ---------- ---------- ---------- ---------- ---------- ISSSSGGDDG SSLLLP--RL LLECS----- ---------- ---------- ---------- ISSCCGGGGN GGLLLDSSEF FFNVKGNNRR RFPII----- ------EEER TTHHLLEENY ISSSSGGGGG FFLLLGEETF FFEVKWAAEE EEAAA----- ------GGGY DDFFWWQQP- ISSSSGGGGG FFLLLGEETF FFEVKWVVEE EESAA----- ------GGGY DDFFWWQQP- ISSCCGGGGN GGLLLDSSDF FFNVKWKKPP PHSPP----- ------GGGY DDFFWWQQP- ISSCCGGGGN GGLLLDSSEF FFNVKWKKPP PHSPP----- ------GGGY DDFFWWQQP- VSSCCGGGGN GGLLLDSSDF FFNIKWKKPP PHSPP----- ------GGGY DDFFWWQQP- VSSCCGGGGN GGLLLDSSDF FFNIKWKKPP PISPP----- ------GGGY HHFFWWQQP- ISSCCGGGGN GGLLLDSSEF FFNVKWKKPP PHSPP----- ------GGGY DDYYWWQQP- ISSTTGGGGN FFLLLGKKTF FFEPKWAADD DKTVV----- ------NNNY DDFFWWQQP- ISSTTGGGGN FFLLLGKKTF FFEPKWAADD DKVVV----- ------NNNY DDFFWWQQP- ---------- ---------- ---------- ---------- ---------- ---------- ISSIIGGGG- DDEEEDKKNF FFELVWRRGG GRKAA----- ------GGGY DDYYWWQQP- ISSVVGGGG- DDLLLDSSDF FFNCIWKKGG GKKAA----- ------GGGY DDFFWWQQP- QDDGGNNLLN GGTTTKHHEN NNGLSGAASS SFEEE----- ------QQQL SSNNHHNNG- TGGLLNNTTA LLYYYDDDGE EEYVAWPPTT TDDMMGVAVV GDAADGGGGY DDIIRRLLI- TGGLLNNTTA LLYYYNAAGE EEYVAWPPTT TGDLLGIKTT G-AADGDDDY DDVVRRLLP- -PNNNELLVV WAVNNN---I IIEEEG-LEE HK-RYNRFFW DDDRRRIIHH HSLTLEEERM -PSSSGMMII WTVRRR---F FFEEEG-FEE CKGAYNKVVW DDDRRHLLYY YAIDLQEERM -PRRRDMMVV WALPPP---F FFEEEG-IEE DLNKYHRFFW DDDRRNVVQQ QTIDLAQQQM -PRRRDMMVV WALPPP---F FFEEEG-IEE DLNKYHRFFW DDDRRNVVQQ QTIDLANNQM -PRRRDMMVV WGLPPP---F FFEEEG-IEE DLNKYHKFFW KKKRRNVVQQ QTIDLANNQM -GYYYDLLVV WGTDDD---V VVEEEG-LDD ILARYRRFFW DDDRRHLLQQ QEIDFDEEQL -GYYYDLLLL WGTRRR---V VVEEEG-VDD ELGKYHRVVW DDDRRHLLQQ QTLDLAEEQM -GYYYDMMVV WGTNNN---I IIEEEG-LQQ ILKGYRRIIW DDDRRHLLQQ QALDVEEEQM -RHHHNMMVV WAANNN---F FFKKKGFNHH VAGLYSRVVW DDDHHIIIQQ QTLQM---GL -RHHHNMMVV WAANNN---F FFKKKGFNHH VAGLYSHVVW DDDHHIIIQQ QTLQM---GL -RHHHNMMII WAANNN---F FFRRRGFNDD VAGLYSHVVW DDDHHIIIQQ QTLTL---GL -RHHHNMMII WAANNN---L LLRRRGFNDD VAGLYSHVVW DDDRRIVVQQ QTLPL---GL -RHHHNMMII WAANNN---L LLRRRGFNDD VAGLYSHVVW DDDHHIVVQQ QTLSL---GL -RHHHNMMII WAANNN---L LLRRRGFNDD VAGLYSHVVW DDDHHIVVQQ QTLSL---GL -RHHHNMMII WAANNN---L LLRRRGFNDD VAGLYSHVVW DDDHHIVVQQ QTLSL---GL -RHHHNMMII WAANNN---L LLRRRGFNDD VAGLYSHVVW DDDHHIVVQQ QTLSL---GL -RHHHNMMII WAANNN---V VVQQQGFNDD VAGLYKHVVW DDDHHIVVQQ QTLLM---GH ---------- ---------- ---------- ---------- ---------- ---------- ---------- SAHNNN---R RRLLLGSRPP AASRVGI--- ---------- ---------- YAWWWGFFWW QCCLLL---Y YYTTTGAECC LASGVVILLD NNNRRIDDEE ESLPL---QA -RHHHNMMII WGAKKK---F FFAAAGFKEE VAGMYHSVVW DDDHHRIIQQ QTIDLE--GL -RHHHNMMII WGAKKK---F FFAAAGFKDD VAGHYHSVVW DDDHHLVVQQ QTIDLK--GL -RHHHNMMII WGATTT---F FFTTTGFDHH VDGLYRHCCI QQQGGLRRQQ QTLDLN--GL -RHHHNMMII WGAKKK---F FFLLLGFNHH VDGLYRHVVY SSSGGIKKQQ QTLDLD--GL -RHHHKMMII WGAKKK---F FFSSSGFDHH VDGLYSHVVY SSSGGMKKQQ QLIDLE--GL -RHHHKMMII WGAKKK---F FFSSSGFNHH VDGLYSHVVY SSSGGIKKQQ QLIDLP--GL -RHHHKMMII WGAAAA---F FFRRRGFDHH VDGLYRHVVY DDDGGLKKQQ QTLDLS--GL -RRRRNMMII WGSNNN---I IIKKKGFNHH VEGLYNSIIF EEEKKYLLQQ QTIDLQPPGA -RRRRNMMII WGSNNN---I IIKKKGFNHH VEGLYNSIIF EEEKKHLLQQ QTIDLMPPGA ---------- RGGVVV---V VVCCCDEECC QEPLVKCVVY ---------- ---------- -HFFFNMMVV WGAKKK---F FFRRRGYHDD CDTQYCRFFY RRRRRLFFQQ QTIDLD--GL -YFFFDMMVV WGANNN---W WWRRRGWKDD LDSQYCRFFY KKKQQLYYQQ QTIDLS--GI --RRRESSEE PDEIII---A AAFFFSSELL KTPLKQHEEV LLL------- ---------- -RKKKNMMLL FTGSSSNYYM MMDDDGQMDD AAKRFNTQQW DDDRRPKKKK KVFNVGAA-- -RKKKNLLVV FTGNNNNYYM MMDDDGKMDD PAKHFNTTTW DDDKKPKKKK KVFDVGAA-- LL---EEEPP LHHDDPTLLL MGGFNMMMVS DLLSSSSIIL LLFEEGGWAA VVIALLLPPP LL---EEEPP LHHDDPTLLL MGGFNVVVVN DLLSSSSIIL LLFEEGGWAA VVIAFLLPPP LL---EEEPP AHHDDPVEEE YGGFGVVVVD NLLGSSSIIT TTWEEGGFVV TTAAALLPPP LL---EEEPP AHHDDPVEEE YGGFGVVVVD NLLASSSIIT TTWEEGGFAA TTAPALLPPP LL---EEEPP AHHDDPSDDD YGGFGVVVVD NLLGAAAIIT TTWDDGGFAA TTIPALLPPP FF---EEEPP AHHDDPTAAA YGGFNCCCVS DLLSSSSIIT TTYDDDDWVV VVIAALLPPP LL---EEEPP AHHDDPTAAA YGGFNCCCVS DLLASSSIIL LLYDDGGWLL VVIAALLPPP LL---EEEPP AHHDDPATTT YGGFGVVVVS DLLASSSVVL LLHQQGGWII VVIAALLPPP PP-LLEEEFF LHHDDPSTTT QGGFGCCCAS IQQFYYYKKE EEG------- --TEIKKKKK PP-LLEEEFF LHHDDPDTTT QGGFGCCCAS IQQFYYYKKE EEG------- --TEIKKKKK PP-LLEEEFF LHHNNPDAAA QGGFGCCCAS IQQFYYYKKQ QQG------- --TEIKKKKK PP-LLEEEFF LHHNNPDAAA QGGFGCCCAS IQQFFFFKKE EEG------- --TQIKKKKK PP-LLEEEFF LHHNNPDAAA QGGFGCCCAS IQQFYYYKKE EEG------- --TEIKKKKK PP-LLEEEFF LHHNNPDAAA QGGFGCCCAS IQQFYYYKKE EEG------- --TEIKKKKK PP-LLEEEFF LHHNNPDAAA QGGFGCCCAS IQQFYYYKKE EEG------- --TEIKKKKK PP-LLEEEFF LHHNNPDAAA QGGFGCCCAS IQQFYYYKKE EEG------- --TEIKKKKK PP-LLEEEFF LHHDDPASSS QGGFGCCCAS IQQFYYYKKE EEG------- --TEIKKKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAILLCCCSS IHHWWKNNNN QDDYVVVVES GRRGSSSDDD DDY------- --AKLAAVVV PP-LLEEEFF LHHDDPDAAA QGGLGCCCAS VFFFYYYKKK KKG------- --KEIKKKKK PP-LLEEEFF LHHNNPDDDD QGGLGCCCAS IFFFYYYKKK KKG------- --KEIKKKKK PP-LLEEEFF LHHDDPADDD TGGFGSSSAS MIIFFFFKKQ QQG------- --SEILLKKK PP-LLEEEFF LHHDDPADDD TGGFGSSSAT MIIFFFFKKQ QQG------- --SEILLKKK PP-LLEEEFF LHHDDPSDDD TGGYGSSSAS MIIFFFFKKS SSD------- --TEILLKKK PP-LLEEEFF LHHDDPSDDD TGGFGSSSAS MIIFFFFKKS SSE------- --TEILLKKK PP-LLEEEFF LHHDDPSDDD TGGYGCCCAT MVVFFFFKKA AAG------- --SEILLKKK PP-LLEEEFF LHHEEPTEEE HAAFGCCCAG IFFIHHHPPE EEN------- --TTAKKKKK PP-LLEEEFF LHHEEPTEEE HAAFGCCCAG IFFIHHHPPE EEN------- --VSAKKKKK ---------- ---------- ---------- ---------- ---------- ---------- PP-LLEEEFF LHHNNPRNNN QGGYGCCCAX XXXXXXX--- ---------- -------QQQ PP-LLEEEFF LHHNNPKAAA EGGFGCCCAN VFFFKKKKKS SSS------- FFEVIVVDDD ---------- ---------- ---------- ---------- ---------- ---------- ---LLEEEFF PWWGGSNNNN YAAFTTTTAT LWWIYYYEED DDG------- -----KKAAA ---LLEEECC AWWGGEANNN YCCFSTTTAT LWWIYYYEEG GGG------- -----KKAAA ILLKPPPKKA APPVVVVTII SSLDDFYYYS GGGGERDSPF FPVVLTKVKK GFAAP----- VLLKDDDKKM MPPVVVVTII SSLDDFYYYS GGGGERDTPH HPRRLARVKK GYEEP----- LLLQGGGGGA APPVVVVTIL SSLDDFYYYS GGGGERDSPH HPVVLASVRR GAAAP----- LLLQGGGGGA APPVVVVTIL SSMDDFYYYS GGGGERDSPR RPKKLASVHH GATTP----- LLLKGGGGGA APPVVVVTIL SSLDDYYYYA GGGGEHDSPM MPVVLTKVEE GVTTP----- VLLKGGGKKA APPVVVVTIL SSMDDFYYYS GGGGDLDSPF FPKKLTKVRR GVAAPGG--- ILLKPPPKKA APPVVVVTIL SSVDDFYYYS GGGGEHDSPF FPRRLTKVQQ GVAAP----- LLLKDDDGGA APPVVVVTIL SSLDDFYYYS GGGGERDSPF FPRRHTSVRR GVAAP----- KGGWMMMPPE EPGIIIITIL SSLDDFYYYS LGGGDRDSPQ QPRRLTQIFF GIGGVQQDEL KGGWMMMPPE EPGIIIITIL SSLDDFYYYS LGGGDRDSPK KPRRLTQIFF GIGGVQQDEL KGGWMMMPPE EPGIIIITIL SSLDDFYYYS LGGGDRDSPQ QPRRLTQLFF GIGGVQQDEL KGGWMMMPPE EPGIIIITIL SSLDDFYYYS LGGGDRDSPQ QPRRLTQLFF GIDDVQQDEL KGGWLLLPPE EPGIIIITIL SSLDDFYYYS LGGGDRDSPQ QPRRLTQLFF GIGGVQQDEL KGGWLLLPPE EPGIIIITIL SSLDDFYYYS LGGGDRDSPQ QPRRL----- ---------- KGGWLLLPPE EPGIIIIT-- ---------- ---------- ---------- ---------- KGGWLLLPPE EPGIIIITIL SSLDDFYYYS LGGGDRDSPQ QPRRLTQLFF GIGGVQQDEL KGGWMMMPPE EPGIIIITIL SSLDDFYYYN LGGGDRDSPK KPRRLVQIFF GIGGVQQDEL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AKKFGGGVVS SSNFFFFPAI FFFDDLIIIL ---------- ---------- ---------- EGGWAAAPPE EPGIIIITII SSLDDFYYYS LGGGDRDTPR RPKKLVQIFF GIGGVTTDDL EGGWPPPPPE EPGIIIITII SSLDDFYYYS LGGGDRDTTR RPKKLVQIFF GIGGVTTDEL QNNWIIIPPE EPGIIIITFI SSLDDFYYYV LGGGDRNELK KPVVLTQLWW GIGGVAAEGK QNNWFFFPPE EPGIIIITFI SSLDDFYYYV LGGGDRNEVK KPKKLTQVWW GIGGVVVDGE ENNWIIIPPE EPGIIIITFI SSLDDFYYYV LGGGDRNEPK KPVVLTQIWW GLGGVKKEGN ENNWIIIPPE EPGIIIITFI SSLDDFYYYV LGGGDRNEPK KPVVLTQIWW GLGGVKKEGN RNNWIIIPPE EPGIIIITFI SSLDDYYYYV LGGGDRNEPA APVVLAQVWW GLGGVVVEDK SGGWAAAPPE EPAIIIITII SSMDDFYYYS LGGGDRDSPL LVKKLNQVYY GVEEVKKGK- ENNWAAAPPD DPAIIIITII SSMDDFYYYS LGGGDRDSPK KPKKLNQVFF GIEEVKKEHD ---------- ---------- ---------- ---------- ---------- ---------- ENNGEEEEEM MGGMMMMTII SSLDDYYYYS RGGGDRDSRA APRRLTQVFF GIDDRRRDEL GSSGVVVEED DGGIIIISII SSLDDFYYYN RGGGDRDTPE EPKKLTQLFF GIDDNVVDEL ---------- ---------- ---------- ---------- ---------- ---------- ADDIGGGPPA AIPPPPPVII AAADDTWWWN MGGGKRDSPH HPFFQIEKVV DV-------- ADDIGGGPPA AVPPPPPVII SSNDDRWWWN MGGGKRDSPH HPRRQVEKTT GV-------- ---------- -AAHKKLAPP QMMLEIIIIS SRDDDRRRVY VTTNNSSSSS TTTWFPPEGG ---------- -SSAEEAAPP QMMISVVVVS SRDDDRRRVY ITTNNSSSSS SSSWFPP-GG ---------- -NNRTTFGPP QMMVEIIIIS SRDDDRRRVY WTTNNSSSSS TTTWFPPDGG ---------- -NNKAAFGPP QMMVEIIIIS SRDDDRRRVY WTTNNSSSSS TTTWFPPDGG ---------- -NNKTTFGPP QMMVEIIIIS SRDDDKRRVY WTTNNSSSSS TTTWFPPGDD --------AA AKKGAALGPP QMMVEIIIIS SRDDDRRRVY FTTNNSSSGG AAAVFPPEGG --------AA ATTAEELGPP QMMVEIIIIS SRDDDRRRVY FTTNNSSSRR AAAWFPPDGG ---------- -AAGPPLGPP QMMVEVVVVS SRDDDRRRVY FSSNNSSSAA SSSWFPPVGG LLCCPPLVVV VKKKRRIGPP QMMIQLLLLS SLDDDKRRLY ATTTTSSSSS DDDWF--PDD LLCCPPLVVV VKKKRRVGPP QMMIQLLLLS SLDDDKRRLY VTTTTSSSSS AAAWF--PNN LLSSPPLVVV VKKKKKVGPP QMMIQLLLLS SLDDDKRRLY VTTTTSSSSS AAAWF--PDD LLSSPPLVVV VKKKQQVGPP QMMIQLLLLS SLDDDKRRLY VTTTTSSSSS AAAWF--PDD LLSSPPLVVV VKKKRRVGPP QMMIQLLLLS SLDDDKRRLY ITTTTSSSSS AAAWF--PDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLSSPPLVVV VKKKRRVGPP QMMIQLLLLS SLDDDKRRLY ITTTTSSSSS AAAWF--PDD LLSSPPLVVV VKKKRRVGPP QMMIQLLLLS SLDDDKRRIY VTTTTSSSSS DDDWF--PDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLCCPPVIVV VKKKKKVGPP QMMIQLLLLS SLDDDKRRLY VTTNNSSSSS KKKWF--PDD LLCCPPVTVV VKKKIIIGPP QMMIQLLLLS SLDDDKRRIY VTTSSSSSSS IIIWF--PDD KKWWSVPEII IQQQKKLGPP QMMIQLLLLT TLDDDKRRLY VTTNNSSSSS AAAWF--PGG EEWWSVPEII IQQKKKLGPP QMMIQLLLLS SLDDDKRRLY VTTNNSSSSS AAAWF--PKK NNFFFVPQII IKKKSSLGPP QMMIQLLLLS SLDDDKRRLY ATTNNSSSSS AAAWF--PEE NNFFFVPQII IKKKSSLGPP QMMIQLLLLS SLDDDKRRLY ATTNNSSSSS AAAWF--PEE KKEEYVPQVV VKKHRRLGPP QMMIQLLLLS SLDDDKRRIY VTTNNSSSSS RRRWFGGQDD ----IALYVV VKKRKKIGPP QMMLQLLLLS SLDDDKRRLY VTTTTSSSKK KKKWF--PEE DD--IALYVV VKKRQQIGPP QMMLQLLLLS SLDDDKRRLY VSSTTSSSKK KKKWF--PEE ---------- -------GPP AKKIQLLLLS SVDDDKRRLY VTTNNSSSSS TTTWF--PNN LLEEPPVFLL LKKRRRLGPP QMMLQLLLLS SLDDDRRRLY VSSSSSSSSS PPPWF--PEE LLEEPARYVV VKKRRRLGPP QMMLQLLLLS SLDDDKRRLY VSSSSSSSSS PPPWF--PKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMVSQQQQS SWDDDKRRVY FSSSSSSSAA NNNW------ ---------- ---------- -MMVSSSSSS SWDDDQRRLY YTTSSSSSAA NNNW------ LLLLKKKKWV VVLL-----S GGGGGLEIDK EFVDDFFEE- --RHHVVVRR LLSSGGDAAS LLLLRRRRWA AAVV-----E GGGGGLELEK EFVDDFFRR- --RHHVVVRR LLWWGGDAAS VVVVPPPPAV VVAA-----D GGGGGLTLAD DYVEEFFDD- --RHHIIIRR LLEEGGDCCS VVVVPPPPVV VVAA-----N GGGGGLELDK DYVSSFFDD- --RHHIIIRR LLEEGGDCCS RRRRGGGGAV VVAA-----N GGGGGLTLDK DFVDDFFAA- --RHHIIIRR LLEEGGDCCS IIIIDDDDWV VVLL-----N GGGGGIEFDP KFLEEWWKK- --RHHVVVRR LLQQGGDCCS IIIIKKKKWV VVVV-----D GGGGGMQFDP NFVDDFFEE- --RHHIIIRR LLQQGGDAAS IIIIRRRRWA AAAA-----G GGGGGLSLDP GFTEEVVDD- --RHHIIIRR LLEEGGDSSS LLLLIIIIES SSMMDVVDTN GGGGGLKLNP NFVDDFFKKP PGLHHLLLRR YYPPGGDCCS LLLLIIIIES SSMMDVVDTN GGGGGLKLNP NFVDDFFKKP PGLHHLLLRR YYPPGGDCCS LLLLIIIIES SSMMDVVDTK GGGGGLKLNP NFVDDFFKKP PGLHHLLLRR YYPPGGDCCS LLLLIIIIES SSMMDVVDTK GGGGGLTLNP NFVDDFFKKP PGLHHLLLRR YYPPGGDCCS LLLLIIIIES SSMMDVVDTK GGGGGLKLNP NFVDDFFKKP PGLHHLLLRR YYPPGGDCCS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLLLIIIIES SSMMDVVDTK GGGGGLKLNP NFVDDFFKKP PGLHHLLLRR YYPPGGDCCS LLLLIIIIES SSMMDVVDTK GGGGGLKLNP NFVDDFFKKP PGLHHIIIRR YYPPGGDCCT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMMMIIIIES SSMMDVVDTK GGGGGLKLNP NFVDDFFKKP PGLHHLLLRR YYPPGGDCCS LLLLLLLLEA AAMMDVVDTK GGGGGLKLNP NFVDDFFKKP PGLHHIIIRR YYPPGGDCCT LLLLVVVVKS SSIIDVVDTK GGGGGLKINP NFVDDFFAAP PGLHHMMMRR YYPPGGDCCT LLLLVVVVQS SSIIDVVDTN GGGGGLKINP NFVDDFFAAP PGLHHMMMRR YYPPGGDCCT LLLLMMMMKS SSIIDVVDTK GGGGGLSINP NFVDDFFDDP PGLHHMMMRR YYPPGGDCCT IIIIMMMMKS SSIIDGGDTK GGGGGLTINP DFVDDFFDDP PGLHHMMMRR YYPPGGDCCT LLLLVVVVKS SSMMDVVDTK GGGGGLSINP NFVDDFFAAP PGLHHMMMRR YYPPGGDCCT HHHHVVVVSA AAMMNIIDPS GGGKKMEINR DFIDDFFKKE EGLHHMMMRR YYPPGGDCCT NNNNVVVVSA AAMMDVVDPT GGGHHMVINK NFIDDFFKKP PGLHHMMMRR YYPPGGDCCT VVVVVVVVES SSMMDVVDTK GGGGGLTVNK NFVDDFFKKP PGLHHIIIRR FFPPGGDSST MMMMVVVVAG GGIIDIIDVN GGGGGMKLNE NFVDDFFGGP PGLHHMMMRR ---------- MMMMVVVVQG GGIIDVVDTN GGGGGISLNE DFVDDFFNNP PGLHHMMMRR YYPPGGDCCT ---------- ---------- ---------- ---------- ---------- ---------- --------KK KKDDLKKAYW DDDGGKELVE DFVDDFFEEG GGRHHMMMRR FFGGSSALLY --------KK KKDDLKKLYW DDDGGKELKE QFIDDFFAAK KGRHHMMMRR FFGGRRALLY SC----- SC----- SCVVR-- SCVV--- SCVV--- SC----- SC----- SC----- II----- II----- IL----- IL----- II----- ------- ------- II----- IL----- ------- ------- ------- IV----- II----- II----- II----- II----- II----- II----- II----- II----- IA----- ------- ILAA--- ------- ------- PGRRVRE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMMAAQQPPS SSEAAAATPR RTAPTLLAAD QSPRTTAAQL LLTTTPSPVI IAAAQQEAAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ----AAGRRS gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MAP ---------- ---------- ---------- ---------- ---------- ---------K ---------- ---------- ---------- ---------- ---------- ---------S ---------- ---------- ---------- ---------- ---------- ---------T ---------- ---------- ---------- ---------- ---------- ---------T ---------- ---------- ---------- ---------- ---------- ---------T ---------- ---------- ---------- ---------- ---------- ---------T ---------- ---------- ---------- ---------- ---------- ---------S ---------- ---------- ---------- ---------- ---------- -----MMTKK ---------- ---------- ---------- ---------- ---------- ---------- AAWTFIVLLA ASSPRSKGRS SVVPPVVSSS AVVAAAQVVQ WWWGGALIAR L-AAAHHTQK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMTKN ---------- ---------- ---------- ---------- ---RGALQSQ RASSSTTTKN ---------- ---------- ---------- ---------- ---------- -----MMTKN ---------- ---------- ---------- ---------- ---------- -----MMTKN ---------- ---------- ---------- ---------- GGGEGHQPWS LEDDDTTTKD ---------- ---------- ---------- ---------- NNNCFDNTET TFTTTSSTKN ---------- ---------- ---------- ---------- ---------- -----MMTKN SSAPTLNRRT TPTPHPLAPP PHHPPPPRRL VRRPPPRIIP HHHSLQMEGA TAAAANNKTH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AKS ---------- ---------- ---------- ---------- ------MATD VEKKKKK-VC ---------- ---------- ---------- ---------- ------MGTQ VEKKKVVNQC ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------L ---------- ---------- ---------- ---------- ---------- MAAAANNAAG ---------- ---------- ---------- ---------- ---------- -PNNNCCLKG ---------- ---------- ---------- ---------- ---------- -----CCLKG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MSK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---RG----- A-AAALLMGF ---------- ---------- ---------- ---------- ---FSGMHFR VLAAALLLAA FDDFFYPPPK KMMKAPPEED VCLYTGNRAF FAVVVKKKSY YSKIVVHKKV EELNDEHFGW LDDFFYPPPR RDDRAPPEED VALYTGNAPF FAVVVKKKSY YGKVIIYKKL DDLGDEHFGW MDDFFHAAPE ELLQAPAEEE TLLSFS-RPA AAVVVGGGSY YGKIVVHTTV TTMGDEHFGW MDDFFHAAPK KLLEAPAEEN TLLSFS-KPA AAVVVGGGSY YGQIVVHTTV TTMGDEHFGW LDDFFYPPAK KLLEGPVEEK TMLSAS-KPG GAVVVTTTSF FGQIVVHQQL IIMGDEHFGW WDDFFYPPPR RLLKAPPEET VMFDRK-QPA AAVVVAAASY YASIVVGQQV AAMGDEHFGW WDDFFYPPPR RMMKAPAEEK VRLNAN-KPA ACVVVQQQSF FGQVVVGVVT DDMGGEHFGW WDDFFYPPPK KMMQAPREER VLLDRE-RPA AGVVVDDDSY YAQIVVGRRV EEMADEHFGW -GGYYPTTLE EAA-GPREEE LCIYTGEAPY YATTTKKKSY YSQVIIHRRL PPMKDEHSGW ---------- ----GPREEE LCIYTGEAPY YATTTKKKSY YSQVIIHRRL PPMKDEHSGW -GGYYPSSLE EAA-GPREEE LCIYTGEAPY YATTTKKKSY YCQVIIHRRL PPMRDEHSGW ---------- ----GPREEE LCIYTGEAPY YATTTKKKSY YCQVIIHRRL PPMKDEHSGW -GGYYSTTLE EAA-GPREEE LCIYTGEAPY YATTTKKKSY YCQVIIHRRL PPMKDEHSGW -GGYYSTTLE EAA-GPREEE LCIYTGEAPY YATTTKKKSY YCQVIIE--- ---------- -GGYYSTTLE EAA-G----- ------EAPY YATTTKKKSY YCQVIIHRRL PPMKDEHSGW -GGYYSTTLE EAA-GPREEE LCIYTGEAPY YATTTKKKSY YCQVIIHRRL PPMKDEHSGW -GGYYPTTQE EAA-GPREEE LCIYTGEAPY YATTTKKKSY YSQVIIHRRL PPMKDEHSGW -GGYYSTTLE EAA-GPREEE LCIYTGEAPY YATTTKKKSY YCQVIIHRRL PPMKDEHSGW -GGYYSTTLE EAA-GPREEE LCIYTGEAPY YATTTKKKSY YCQVIIHRRL PPMKDEHSGW TGGYYATTLE EAAKGPREEK VCVYTGNKLY YATTTSSSSY YSQVIIHRRL PPVGDKHSGW ---------- ---------- ---------- ---------- ---------- --MNDEHSGW -GGYYKSSLD DAA-GPREEE LCIYTGNKPY YATTTKKKSY YSQVIIHRRL PPMNDEHSGW CGGYYASSIE ESS-GPREES VAVYTGEKPY YATTTSSSSY YSKVIIHRRL PPVGDEHTGW CGGYYASSLE EAA-GPREET VAVYTGEKPY YATTTNNNSY YSKVIIHRRL PPVGDEHTGW ---------- ---------- ---------- ---------- ---------- --MGDEHSGW QGGYYATTLA AAA-GPSEEK VAVYTGDKPY YATTTSSSSY YSSVIIHRRL PPMGDEHSGW GGGYYATTLE EAAKGPREEK VCVYTGNKPY YGTTTNNNSY YSQVIIHRRL PPVGDEHSGW -GGYYASSAD DAA-GPREEE VAP-NADGPA AFTTTEEESF FCQVIISRRV DDVGDEHTGW -GGYYASSAD DAA-GPREEE VAP-HADGPA AFTTTEEESF FCQIIISRRV DDVGDEHTGW ---------- ---------- ---------- ---------- ---------- ---------- CGGYYATTLD DAANGPVEEK VCVQLDEHGY YATTTAAASY YCQVIIHRRT YYTHNEHSGW ---------- ---SGPREEK TTVQLDPHGY YSTTTEEESY YCQIVVHRRT FFTGDEHSGW -MMLLITT-D DIISLDDRRF SWLHIRYDID DKNNNQQQVG GGSVLLKDDG PPVEDKDSQP RAATTCQQPY YMMITGQEEE VTLGGMDEQK KVTTTGGGSR RGQVIINSSV SSVRNEHGGF GAATTCAAPY YMMITGQEED VTLGGVDEQK KVTTTKKKSY YGKVVVNTTL SSVRNEHSDF WNACSSSACP NGKKNIIRFF LVVPGLLLRS SRYIDDKPPP NNNPPIIKKK VEEEEVKKKS WNACSSSACP NAKKFLLRYY LVVPALLLRS SRYIDDKPPP DDDKPVAKKK IEEEEAVVGT WNACSSSSSP LTHHFLLRFF LIIPGLLLRS SRYVDDKPPP HHHPAIHKKK IEDDDILLAT WNACSSSASP LAHHFIIRYY LIIPGLLLRS SRYIDDKPPP DDDPAIHKKK IEEEEVFFKT WNACSSSASP LTHHFLLRYY LIIPGIIIRS SRYIDDK--- EEEPAIHKKK IEEEEVFFAT WNACSSSCCP NAHHHMMRYY LVVPGLLLRS SRYIDDKPPP DDDPPLAKKK VEEEELAAET WNACSSSMCP NAHHHVVRYY LVVPDIIIRS SHTIDDKPPP DDDPPVVKKK VDNNNLAAET WNACSSAACP YAHHHVVRYY LVVPGIIIRS SRHIDDKPPP DDDPPIVKKK VEEEELHHRT WNTCSSSC-- -FDDTKKRKK LLLPGLLLMS SRYVDDGSSS EEEPPLHKKK VESSSIQQAC WNTCSSSC-- -FDDTKKRKK LLLPSIIIIS SRYVDDGSSS EEEPPLHKKK VENNNIHHAC WNACSSSC-- -FDDTKKRKK LLLPCLLLMS SRYVDDGSSS DDDPPLHKKK VEEEEIHHAC WNTCSSSC-- -YDDTKKRKK LLLPALLLIS SRYVDDGTTT EEEPPLHKKK VEKKKIHHTC WNTCSSSC-- -FDDTKKRKK LLLPSLLLIS SRYVDDGSSS EEEPPLHKKK VEEEEIHHAC ---------- ---------- ---------- ---------- ---------- --KKKIHHAC WNTCSSSC-- -FDDTKKRKK LLLPSLLLIS SRYVDDGSSS EEEPPLHKKK VEKKKIHHAC WNTCSSSC-- -FDDTKKRKK LLLPSLLLIS SRYVDDGSSS EEEPPLHKKK VEKKKIHHAC WNTCSSSC-- -FDDTKKRKK LLLPSFFFIS SRYVDDGTTT EEEPPLHKKK VEKKKIHHEC WNTCSSSC-- -FDDTKKRKK LLLPSLLL-- ---------- ---------- ---------- WNTCSSSC-- -FDDTKKRKK LLLPSLLLIS SRYVDDGSSS EEEPPLHKKK VEKKKIHHAC WNSCSSSC-- -HDDSAARFF LLLPSLLLLS GRYVDDATTT DDDPPLHKKK VEEEEIAAEI WNTCSSSC-- -YDDSKKRKK LLLPCLLLIS SRYVDDGTTT DDDPPIHKKK TEYYYVFFWC WNTCSSSC-- -YDDSKKRKK LLLPCLLLIS SRYVDDGSSS DDDPPIHKKK TEYYYVFFWC WNSCSSSC-- -HDDSAARFF LAAPSLLLVS GRYVDDKTTT NNNPPLHKKK VDAAAIIIQT WNSCSSSC-- -HDDSAARFF LVVPGIIIVS GRYVDDKTTT NNNPPLHKKK VEEEEISSTT WNSCSSSC-- -HDDSAARYY LLLPSLLLIS GRYADDKEEE NNNPPLYKKK YDKKKIAAET WNSCSSSC-- -HDDSVVRYY LLLPSLLLIS GRYADDKEEE NNNPPLYKKK YDKKKIAADT WNACSSSC-- -HDDSAARFF LLLPSLLLLS GRYVDDLKKK DDDPPLHKKK VEEEEIAAET WNACSSSC-- -HKKTEERHH LVVPCLLLNS DRYINNENNN EEE-ILEHHH TESSSLHHSN WNACSSSC-- -HKKTEERHH LVVPCLLLNS DRYVNNENNN EEE-ILQHHH TESSSLHHAN ---------- ---------- MPPRKLLLSS GVGKFFGGGG ---------- ---------- WNTCSSSCFP -GKKVPPRRR LLLPCLLLNS DRFVDDGTTT DDDPPLAKKK VE---VLLKA WNACSSSCYD ESKKVPPRRR LLLPSLLLNS DFYIDDVTTT DDDPPIVKKK TD---VLLKH PTPRIILK-- --KKVQQGQQ MQQLSLLLDG KRYVTTLYYY SSSAKFYPPP -----LIIKL FSA------- -------RFF FTTGGLLLDT NRFIDDHSSS DDDPPLHKKK TD---VKKDG FTD------- -------RYY LAAGGLLLDT SKFVDDHSSS DDDPPLSKKK TT---VEEKG SGGGYYSRLH TVHGGPPAII IILGE--EEG PPGGGIIIMM LLLYSSFFEK WWIDRRGDDY TGGGYYTKYH TVHGGPPAII IILGP--EEG PPGGGIIILL LLLDTTFFER WWVYRRGPPY TGGGYYSRPH TVHGGPPGII VVLGAGGDDG AAGGGIIIII MMMETTFFDR WWIDRRGPPD TGGGYYSRPH TIHGGPPGII VVLGGGGNNG PPGGGVVVII MMMETTFFER WWIDRRGPPT TGGGYYSRPH TIHGGPPGII VVLGGGGDDG PPGGGIIIII LLLETTFFER YYMDRRGEET TGGGYYSRPH TVHGGPPGII VVLGA--KKG PPGGGIIIMM LLLQSSFFER WWVERRGPPY TGGGYYARPH TVHGGPPGII IILGP--EEG PPGGGIIIII LLLDNNLLER WWIDRRGDDY TGGGYYSRPH TIHGGPPGVV VVLGP--DDG PPGGGVVVVV MMMESSFFDR WWVERRGPPQ CNNNVVSNTH TSHLLAAGEE MMTLD--NNG KKSSSFFFLL LLLETTFFET WWKPGGGAAP CNNNLLGNLH TSHLLAAGEE MMSLD--NNG KKGGGFFFLL LLLETTFFET WWKPGGGEEP CGGGLLGYVH TSHLLAAGEE MMTLD--NNG KKGGGFFFLL LLLETTFFET WWQPGGGAAP CNNNLLGFFH TSHLLPPGEE MMTLD--NNG KKGGGFFFLL LLLKTTFFET WWQPGGGAAP CEEELLAFLH TSHLLAAGEE MMSLD--NNG KKGGGFFFLL LLLETTFFET WWRPGGGAAP CEEELLAFLH TSHLLAAGEE MMSLD--NNG KKGGGFFFLL LLLETTFFET WWRPGGGAAP CEEELLAFLH TSHLLAAGEE MMSLD--NNG KKGGGFFFLL LLLETTFFET WWRPGGGAAP CEEELLAFLH TSHLLAAGEE MMSLD--NNG KKGGGFFFLL LLLETTFFET WWRPGGGAAP CGGGLLGTPH TSHLLPPGEE MMTLD--NNG KKGGGFFFLL LLLETTFFET WWRPGGGSSP ---------- ---------- ---------- ---------- ---------- ---------- CEEELLAFLH TSHLLAAGEE MMSLD--NNG KKGGGSSSVV LLL-RRLLE- ---------- IGGGLLGFPH TSHLLAAGDD MMCLD--NNA AANNNGGGLL LLLSEEFFNR GGNRLLFPPS CGGGLLANLH TSHLLGGGEE MMSID--NNG KKGGGFFFLL LLLETTFFEN WWAEGGEAAP CGGGLLANPH TSHLLGGGEE MMSLD--NNG KKGGGFFFLL LLLETTFFEN WWVEGGESSQ TGGGLLAYPH TSHLLAAGEE MMCLD--NNA EENNNGGGLL LLLSDDFFNR WWKPGGHSSL TGGGLLAYPH TSHLLAAGEE MMCID--NNA EENNNGGGLL LLLSEEFFNR WWKPGGHSSL TGGGLLAYPH TAHLLAAGEE LLCLD--NNA KKNNNGGGLL LLLSDDFFNR WWKPGGHSSL TGGGLLAFPH TAHRRTTGEE LLCLD--NNA KKNNNGGGLL LLLSDDFFNR WWKPDDISSL TGGGLLGFPH TSHLLAAGEE MMCLD--NNA AANNNGGGLL LLLSEEFFNR WWKPGGHSSL N---LLSFPH TSHLLAAGNN MMTLE--TTP SSNNNFFFLL LLLKTTFFET WWADEEKTTP N---LLSFPH TSHLLAAGNN MMTLE--SSP SSNNNFFFLL LLLKTTFFET WWADGGKVVP ---------- ---------- ---------- ---------- ---------- ---------- ADDDCCTAPH TTHLLPPGNN MMIMD--NNA KK---DDDVV EEEKNNFFET WWRGDDRKKL HNNNVVTAPH TTHLLAAGNN MMVMD--YYA KK---DDDII LLLSDDFFNT WWKGDDKKKL LVVVLLAISH TADQQPPTAA KKGVE--VVP VVNNNGGGQQ TTTHEENNGK GGASQQFEEI GGGGVVVGPH TFFLLPPSMM IILSD--GGG RRAAALLLEE YYYDGGEEYY WWPTAADDDQ GGGGVVVGPH TLYLLPPRMM IILSN--GGG RRAAALLLEE YYYAGGEEYH WWPTDDGDDR Y--------- -------LAA YDDFFFFWWW WLL-PPNEEV VVLSEEEWWW AAVPN--TTT Y--------- -------FAA YDDFFFFWWW WLL-PPSGGV VVMTEEEWWW TTVPR--CCC D--------- -------KHH YDDFFFFWWW WLL-PPRDDY YYMSEEEWWW AALPP--QQQ T--------- -------LHH YDDFFFFWWW WLL-PPRDDY YYMTEEEWWW AALPP--QQQ T--------- -------KHH YDDFFFFWWW WLL-PPRDDY YYMSEEEWWW GGLPP--QQQ Y--------- -------FAA YDDGGGGWWW WLL-GGYDDT TTLTEEEWWW GGTPD--MMM Y--------- -------LHH YDDFFFFWWW WLL-GGYDDT TTLTEEEWWW GGTPR--MMM Q--------- -------LAA YDDFFFFWWW WLL-GGYDDT TTMTEEEWWW GGTPN--MMM P--------- -------MGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW AAAPN--VVV P--------- -------MGG YDDFFFFWYY YPP-RRHNNI IIMSEEEWWW AAAPN--VVV P--------- -------MGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW AAAPN--VVV P--------- -------LGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW AAAPN--VVV P--------- -------SGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW AAAPN--VVV P--------- -------LGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW AAAPN--VVV P--------- -------LGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW AAAPN--VVV P--------- -------LGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW AAAPN--VVV P--------- -------MGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW AAAPN--VVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----IIISSS AAHSN--LLL S--------- -------KEE RTTHHHHLYY YNNYAAWGGL LLFSIIIQQQ CCCSL--FFF P--------- -------FGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW GGAPK--AAA Q--------- -------FGG YDDFFFFWYY YPP-RRHNNV VVMSEEEWWW GGAPK--AAA L--------- -------FGG YDDFFFFWYY YPP-RRHNNT TTMSSSSWWW GGAPT--AAA L--------- -------FGG YDDFFFFWYY YPP-RRHNNT TTMSSSSWWW GGAPK--AAA L--------- -------FGG YDDFFFFWYY YPP-RRHKKT TTMSSSSWWW GGAPK--AAA L--------- -------YGG YHHFFFFWYY YPP-RRHKKT TTMSSSSWWW GGAPK--AAA L--------- -------FGG YDDYYYYWYY YPP-RRHKKT TTMSSSSWWW GGAPA--AAA P--------- -------FNN YDDFFFFWYY YPP-RRRNNV VVMSEEEWWW GGSPN--HHH P--------- -------FNN YDDFFFFWYY YPP-RRRNNI IIMSEEEWWW GGSPN--HHH ---------- ---------- ---------- ---------- ---SLLLRRR GGGPV--TTT L--------- -------CGG YDDYYYYWYY YPP-HHFNNV VVMAEEEWWW GGAPK--LLL L--------- -------CGG YDDFFFFWYY YPP-YYFDDV VVMSEEEWWW GGAPN--KKK I--------- -------LQQ LSSNNNNHNN NGG---REEK KKSSRRRPPP DDEPI--MMM QVVVAVVGGD DAVAADGYGG YDDIIIIRAA AII-RRKNNV VVMTSSSFFF TTGWSNNMMM RIIIKTTGG- -KYAADGYDD YDDVVVVRAA APP-RRKNNL LLLTSSSFFF TTGWNNNMMM EDDKKKKKLH LLLKKD-RYY GGNRRRRDRR RRRRRHHLTT GENMAL---- ---EERRRPL EEESSSSSLC LLLKKEGAYY GGNKKKKDAA RHHHHYYIDD GQHMVL---- ---EERRRPL ENNVVVVVPD LLLLLANKYY GGHRRRRDRR RNNNNQQIDD GAHMAL---- ---EERRRPA ENNVVVVVPD LLLLLSNKYY GGHRRRRDRR RNNNNQQIDD GAHMAL---- ---EERRRPA ENNVVVVVPD LLLLLSNKYY GGHKKKKKRR RNNNNQQIDD GAHMAL---- ---EERRRPA EDDVVVVVPI LLLLLGARYY GGRRRRRDTT RHHHHQQIDD GDHLVF---- ---EERRRPA ESSLLLLLGE LLLLLAGKYY GGHRRRRDYY RHHHHQQLDD GAYMAL---- ---EERRRPA EGGDDDDDPI LLLLLNKGYY GGRRRRRDRR RHHHHQQLDD GEHMVL---- ---EERRRPA KDDPPPPPAV EEEAA-GLYY GGSRRRRDQQ HIIIIQQLQQ T-DLIP---- --LEERRRFL KDDPPPPPAV EEEAA-GLYY GGSHHHHDQQ HIIIIQQLQQ K-DLIP---- --LEERRRFL RDDPPPPPAV EEEAA-GLYY GGSHHHHDQQ HIIIIQQLTT Q-DLIP---- --LEERRRFL RDDPPPPPAV KKKAA-GLYY GGSHHHHDQQ RIIIIQQLPP Q-DLIP---- --LEERRRFL RDDPPPPPAV EEEAA-GLYY GGSHHHHDQQ HIIIIQQLSS K-DLIP---- --LEERRRFL RDDPPPPPAV EEEAA-GLYY GGSHHHHDQQ HIIIIQQLSS K-DLIP---- --LEERRRFL RDDPPPPPAV EEEAA-GLYY GGSHHHHDQQ HIIIIQQLSS K-DLIP---- --LEERRRFL RDDPPPPPAV EEEAA-GLYY GGSHHHHDQQ HIIIIQQLSS K-DLIP---- --LEERRRFL QNNPPPPPAV EEEAA-GLYY GGKHHHHDQQ HIIIIQQLLL P-DHIP---- --LEERRRFL ---------- ---------- ---------- ---------- ---------- ---------- LTTDDDDDYA SSSAA-SRVV AAGIIII--- ---------- ---------- ---------- TTTLLLLLML TTTAA-SGVV HHVIIIINII RIIIIEELPP Q-DAGANNNI IILCCRRRSI ALLMMMMMEV QQQAA-GMYY GGHSSSSDTT HRRRRQQIDD GEDLIP---- --LEERRRFL ALLMMMMMEV QQQAA-GHYY GGHSSSSDTT HLLLLQQIDD GKDLIP---- --LEERRRFL TKKLLLLLQV AAADD-GLYY GGRHHHHQAA GLLLLQQLDD GNTLLP---- --LEERRRFL LQQLLLLLQV AAADD-GLYY GGRHHHHSPP GIIIIQQLDD GDKLLP---- --LEERRRFL SKKLLLLLQV AAADD-GLYY GGSHHHHSPP GMMMMQQIDD GETLLP---- --LEERRRFL SKKLLLLLQV AAADD-GLYY GGSHHHHSPP GIIIIQQIDD GPTLLP---- --LEERRRFL RTTLLLLLQV QQQDD-GLYY GGRHHHHDPP GLLLLQQLDD GSTLLP---- --LEERRRFL KKKPPPPPAV GGGEE-GLYY GGNSSSSEDD KYYYYQQIDD PQLALP---- --LEERRRFL KKKPPPPPAV PPPEE-GLYY GGNSSSSEDD KHHHHQQIDD PMRALP---- --LEERRRFL CRRLLLLLKQ PPPEE-PLVV IIKCCCC--- ---------- ---------- ---------- RRRPPPPPTC DDDDDRTQYY GGCRRRRRQQ RLLLLQQIDD GDDLTP---- --LEERRRFL RRRNNNNNVL EEEDDMSQYY GGCRRRRKSS QLLLLQQIDD GSDITP---- --LEERRRFL FEESSSSSFK KKKTTGPLKK PPQHHHHL-- ---------- ---------- ---------- DFFLLLLLQA EEEAAMKRFF GGNTTTTDHH RPPPPKKFNN PGP------- --LEERRRFP DFFLLLLLAP EEEAAMKHFF GGNTTTTDHH KPPPPKKFDD PGP------- --LEERRRCA HDTLLMMGFI IINNVVVVSS DSSSSSIIIW LDDNAAEEKV IEPAEEEPG- -LLLLLKKPP HDTLLMMGFV VVNNVVVLNN DSSSSSIIIW LDDQAAEERV IDEAQQQPG- -LLLLLKKDD HDVEEYYGFV VVGGVVVVDD NEEGSSIIIW TGGHVVKKKT ATPAEEEPAD DLLLLLQQGG HDVEEYYGFV VVGGVVVVDD NEEASSIIIW TGGHAAEEKT ATPPEEEPKE ELLLLLQQGG HDSDDYYGFC CCGGVVVVDD NQQGAAIIIF TDDEAAKKKT ITDPVVVPAD DLLLLLKKGG HDTAAYYGFV VVNNVVVISS DSSSSSIIIW TKKAVVRRKV IEPAEEEAPD DLLLLLKKGG HDTAAYYGFM MMNNVVVVSS DSSASSIIIW LNNHLLKKKV IDPAEEEPED DLLLLLKKPP HDATTYYGFV VVGGVVVVSS DSSASSVVVW LNNGIIRRKV IEPAEEEPPD DLLLLLKKDD HDSTTQQGFV VVGGAAALSS IRRFYYKKKN E--------- TWVEKKKVVP PGGGGGWWMM HDDTTQQGFV VVGGAAALSS IRRFYYKKKN E--------- TWVEKKKVVP PGGGGGWWMM HNDAAQQGFV VVGGAAALSS IRRFYYKKKN Q--------- TWVEKKKVVP PGGGGGWWMM HNDAAQQGFV VVGGAAALSS IRRFFFKKKN E--------- TWAQKKKVVP PGGGGGWWMM HNDAAQQGFV VVGGAAALSS IRRFYYKKKN E--------- TWVEKKKVVP PGGGGGWWLL HNDAAQQGFV VVGGAAALSS IRRFYYKKKN E--------- TWVEKKKVVP PGGGGGWWLL HNDAAQQGFV VVGGAAALSS IRRFYYKKKN E--------- TWVEKKKVVP PGGGGGWWLL HNDAAQQGFV VVGGAAALSS IRRFYYKKKN E--------- TWVEKKKVVP PGGGGGWWLL HDASSQQGFV VVGGAAALSS IRRFYYKKKN E--------- TWVEKKKVVP PGGGGGWWMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- HWNNNQQDYD DDVVEEEVSS GGGGSSDDDP D--------- AVLKRRRKLY YKKKKKFFGG HDDAAQQGLV VVGGAAALSS VRRFYYKKKE K--------- KWAEKKKVVP PGGGGGWWAA HNDDDQQGLV VVGGAAALSS IRRFYYKKKE K--------- KWAEKKKVVP PGGGGGWWPP HDADDTTGFV VVGGAAALSS MRRFFFKKKT Q--------- SWHELLLAVK KNNNNNWWII HDADDTTGFV VVGGAAALTT MRRFFFKKKT Q--------- SWHEIIIVVE ENNNNNWWFF HDSDDTTGYV VVGGAAALSS MRRFFFKKKN S--------- TWYEIIIVVK KNNNNNWWII HDSDDTTGFV VVGGAAALSS MRRFFFKKKN S--------- TWHEVVVVVK KNNNNNWWII HDSDDTTGYV VVGGAAALTT MRRFFFKKKT A--------- SWHEVVVAIK KNNNNNWWII HETEEHHAFV VVGGAAALGG IRRIHHPPPV E-------T- THATLLLVIP PGGGGGWWAA HETEEHHAFV VVGGAAALGG IRRIHHPPPD E-------K- VQASLLLVIP PNNNNNWWAA ---------- ---------- ---------- ---------- ---------- ---------- HNRNNQQGYV VVGGAAAFXX XXXXXX---- ---------- ---------- -NNNNNGGEE HNKAAEEGFV VVGGAAALNN VHHFKKKKKK S-------EF EAKVIIIDGK KSSSSSGGVV ---------- ---------- ---------- ---------- ---------- ---------- WGNNNYYAFS SSTTAAALTT LLLIYYEEED D--------- --------WQ QDDDDDIIGG WGANNYYCFT TTSSAAALTT LLLIYYEEED G--------- --------WQ QDDDDDIIGG KKKAALLVVV VTDIIDDKKK FLLLSWWGIG GGGEVVVVVY DDSNPPPFKK PPVLVKLGGI KKKMMLLVVV VTDIIDDRRR FLVVSWWGLG GGGELLLLLY DDTNPPPHQQ PPRLVKIGGL GGGAALLVVV VTDIIDDRRR FLVVSWWGTG GGGEMMMMMY DDSDPPPHNN PPVLVRIGGI GGGAALLVVV VTDIIDDRRR FLVVSWWGTG GGGEMMMMMY DDSDPPPRKK PPKLVHIGGI GGGAALLVVV VTDIIDDKKK YLVVAWWGLG GGGEMMMMMY DDSDPPPMNN PPVLVEIGGI KKKAALLVVV VTDIIDDRRR FLVVSWWGTG GGGDLLLLLY DDSDPPPFEE PPKLVRIGGI KKKAALLVVV VTDIIDDRRR FLVVSWWGTG GGGELLLLLY DDSDPPPFNN PPRLVQIGGI GGGAALLVVV VTDIIDDRRR FLVVSWWGTG GGGELLLLLY DDSDPPPFNN PPRHVRLGGI PPPEELLIII ITDIIDDRRR FLFFSWWLHG GGGDIIIIIY DDSNPPPQKK PPRLIFLGGS PPPEELLIII ITDIIDDRRR FLFFSWWLHG GGGDIIIIIY DDSNPPPKKK PPRLIFLGGS PPPEELLIII ITDIIDDRRR FLFFSWWLHG GGGDLLLLLY DDSDPPPQRR PPRLLFLGGS PPPEELLIII ITDIIDDHHH FLFFSWWLHG GGGDIIIIIY DDSDPPPQRR PPRLLFLGGS PPPEELLIII ITDIIDDRRR FLFFSWWLHG GGGDLLLLLY DDSDPPPQRR PPRLLFLGGS PPPEELLIII ITDIIDDRRR FLFFSWWLHG GGGDLLLLLY DDSDPPPQRR PPRL------ PPPEELLIII IT-------- ---------- ---------- ---------- ---------- PPPEELLIII ITDIIDDRRR FLFFSWWLHG GGGDLLLLLY DDSDPPPQRR PPRLLFLGGS PPPEELLIII ITDIIDDRRR FLFFNWWLHG GGGDMMMMMY DDSDPPPKRR PPRLIFLGGS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVSSEEFFF FPPAADDLLL LIFFL----- ---------- ---------- ---------- PPPEELLIII ITDIIDDRRR FLFFSWWLHG GGGDIIIIIY DDTDPPPRNN PPKLIFLGGS PPPEELLIII ITDIIDDRRR FLFFSWWLHG GGGDIIIIIY DDTDTTTRNN PPKLIFLGGS PPPEELLIII ITDFFDDRRR FLFFVWWLHG GGGDIIIIIY NNEDLLLKNN PPVLLWVGGL PPPEELLIII ITDFFDDRRR FLFFVWWLHG GGGDIIIIIY NNEDVVVKNN PPKLVWAGGL PPPEELLIII ITDFFDDRRR FLFFVWWLHG GGGDIIIIIY NNEDPPPKNN PPVLIWVGGL PPPEELLIII ITDFFDDRRR FIFFVWWLHG GGGDIIIIIY NNEDPPPKNN PPVLIWVGGL PPPEELLIII ITDFFDDRRR YLLLVWWLHG GGGDIIIIIY NNEDPPPAKK PPVLVWAGGL PPPEELLIII ITDIIDDRRR FLVVSWWLHG GGGDIIIIIY DDSDPPPLKK VVKLVYIGGS PPPDDLLIII ITDIIDDRRR FLVVSWWLHG GGGDIIIIIY DDSDPPPKNN PPKLVFIGGS ---------- ---------- ---------- ---------- ---------- ---------- EEEMMMMMMM MTDIIDDRRR YLFFSWWRHG GGGDVVVVVY DDSDRRRANN PPRLVFLGGA EEEDDMMIII ISDIIDDRRR FLVVNWWRHG GGGDVVVVVY DDTDPPPENN PPKLLFLGGA ---------- ---------- ---------- ---------- ---------- ---------- PPPAALLPPP PVDIIDDQQQ TLIINFFMDG GGGKTTTTTF DDSDPPPHKK PPFQKVIDRQ PPPAALLPPP PVDIIDDSSS RLVVNFFMDG GGGKTTTTTF DDSDPPPHHH PPRQKTIGAQ FFHHRRDHPP ---------- ---------- --HHLTTGGL EEISRRDRRR RVVVTNNLLL YYHHRRPHPP ---------- ---------- --AAATTGGI SSVSRRDRRR RVIITNNLLL AARRRRPHPP ---------- ---------- --RRFAAGGV EEISRRDRRR RVWWTNNLLL AARRRRPHPP ---------- ---------- --KKFAAAAV EEISRRDRRR RVWWTNNLLL VVKKKKPHPP ---------- ---------- --KKFGGYYV EEISRRDKRR RVWWTNNLLL VVSSRRTHPP G--------- ---------- -AGGLNNGGV EEISRRDRRR RVFFTNNLLL VVRRRRGHPP ---------- ---------- -AAALNNGGV EEISRRDRRR RVFFTNNLLL VVRRKKAHPP ---------- ---------- --GGLNNGGV EEVSRRDRRR RVFFSNNLLL IIVVRRGSVV QVVLLEE-DD DQLLTQQQPL VVKKIPPGGI QQLSLLDKRR RLAATTTLLL IIVVKKGSVV QVVLLEE-DD DQLLTQQQPL VVKKVPPGGI QQLSLLDKRR RLVVTTTLLL IIVVKKGPVV QVVLLEE-DD DQLLKQQQPL VVKKVPPGGI QQLSLLDKRR RLVVTTTLLL IIVVKKGPVV QVVLLDD-DD DQLLDQQQPL VVKKVAAGGI QQLSLLDKRR RLVVTTTLLL IIVVKKGPVV QVVLLEE-DD DQLLKQQQPL VVKKVAAGGI QQLSLLDKRR RLIITTTLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIVVKKGPVV QVVLLEE-DD DELLKQQQPL VVKKVAAGGI QQLSLLDKRR RLIITTTLLL IIVVKKGPVV QVVLLEE-DD DQLLKQQQPL VVKKVPPGGI QQLSLLDKRR RIVVTTTLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IILLRRGPVV TVVLLEE-DD DKLLEQQQPV IVKKVPPGGI QQLSLLDKRR RLVVTNNLLL IIQQRRGPVV TVVLLEE-DD DKLLEQQQPV TVKKIPPGGI QQLSLLDKRR RIVVTSSLLL IIQQKKSPVV AAAIIGG-EE EDKKTQQQSP EIQQLRRGGI QQLTLLDKRR RLVVTNNLLL IIQQKKSPVV VAAVVKK-DD DDEETQQQSP EIKKLRRGGI QQLSLLDKRR RLVVTNNLLL LLQQKKSPVV KAAVVGG-EE EDNNSQQQFP QIKKLRRGGI QQLSLLDKRR RLAATNNLLL LLQQKKSPVV KAAVVGG-EE EDNNTQQQFP QIKKLRRGGI QQLSLLDKRR RLAATNNLLL LLQQKKSEVV VYYVVTT-EE EDKKEQQQYP QVHHLRRGGI QQLSLLDKRR RIVVTNNLLL VVHHTTSNVV KVVLLEE-GG GE---PPPIL YVRRIEEGGL QQLSLLDKRR RLVVTTTLLL IIHHSSTTVV KVVLLEE-EE EDDD-EEEIL YVRRIEEGGL QQLSLLDKRR RLVVSTTLLL ---------- ---------- ---------- -------GGI QQLSVVDKRR RLVVTNNFFF IIQQRRAPRR RVVLLNN-DD DPLLKAAAPV FLRRLLLGGL QQLSLLDRRR RLVVSSSLLL IICCSSLPNN VIIVVKKEDD DKLLKRRRPR YVRRLEEGGL QQLSLLDKRR RLVVSSSLLL ---------- ---------- ---------- ---------- ---------- ---------- VVNN------ ---------- ---------- ---------V SSQSWWDKRR RVFFSSSLLL VVNN------ ---------- ---------- ---------V SSSSWWDQRR RLYYTSSLLL LYSTTQYYEG GLLGGMMLNN --SGGGEIID KKFVVDDDFG ----ARRSGD SYYCCYPP-- LYSSSQYY-G GLLGGMMVNN --EGGGELLE KKFVVDDDFG ----ARRWGD SFFCCYPP-- LYSTTQYYDG GVVAAQQAHG --DGGGTLLA DDYVVEEEFP ----YRREGD SFFCCYPPSS LYSTTQYYDG GVVGGEEANG --NGGGELLD KKYVVSSSFP ----YRREGD SFFCCYPPSS LYSTTQYYGD DRRAAMMANG --NGGGTLLD KKFVVDDDFP ----YRREGD SFFCCYPPSS LYGAAQYYEG GIIGGMMLDG --NGGGEFFD PPFLLEEEWP ----HRRQGD SYYCCYPP-- LYRAAQYYDG GIIGGMMVDN --DGGGQFFD PPFVVDDDFG ----QRRQGD SYYCCFPP-- LYASSQYYVG GIIGGIIAED --GGGGSLLD PPFTTEEEVG ----LRREGD SYYCCYPPSS LYSDDQYYPD DLLRRGGMLV VTNGGGKLLN PPFVVDDDFG PLLPALRPGD SWWII----- LYSAAQYYPN NLLRRGGMLI VTNGGGKLLN PPFVVDDDFG PLLPALRPGD SWWII----- LYSAAQYYPD DLLRRGGMLI VTKGGGKLLN PPFVVDDDFG PLLPALRPGD SWWLL----- LYSAAQYYPD DLLRRGGMLI VTKGGGTLLN PPFVVDDDFG PLLPALRPGD SWWLL----- LYSAAQYYPD DLLRRGGMLV VTKGGGKLLN PPFVVDDDFG PLLPALRPGD SWWII----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LYSAAQYYPD DLLRRGGMLV VTKGGGKLLN PPFVVDDDFG PLLPALRPGD SWWII----- LYSDDQYYPD DLLRRGGMLI VTKGGGKLLN PPFVVDDDFG PLLPALRPGD TWWLL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LYSKKQYYPD DMMKKGGMLI VTKGGGKLLN PPFVVDDDFG PGGPVLRPGD SWWVV----- LYSIIQYYPD DLLKKGGMLI VTKGGGKLLN PPFVVDDDFG PDDPVLRPGD TWWII----- LFSAAQYYPG GLLEEGGILI VTKGGGKIIN PPFVVDDDFG PDDPALRPGD TWWII----- LFSAAQYYPK KLLEEGGILI VTNGGGKIIN PPFVVDDDFG PDDPSLRPGD TWWII----- LFSAAQYYPE ELLDDGGIII VTKGGGSIIN PPFVVDDDFG PEEPALRPGD TWWII----- LFSAASYYPE EIIEEGGIII GTKGGGTIIN PPFVVDDDFG PDDPSLRPGD TWWII----- LFSRRQYYQD DLLKKGGMLI VTKGGGSIIN PPFVVDDDFG PEEPSLRPGD TWWII----- LYKKKQYYPE EHHKKGGMVV IPSGGKEIIN RRFIIDDDFG EGGPYLRPGD TWWII----- LYKKKQYYPE ENNRRGGMLI VPTGGHVIIN KKFIIDDDFG PGGPYLRPGD TWWII----- FYSTTQYYPN NVVKKGGMLI VTKGGGTVVN KKFVVDDDFG PNNPCLRPGD TLLAA----- LFSPPQYYPE EMMAAGGIVL IVNGGGKLLN EEFVVDDDFG PYYPGLR--- ---------- LYSPPQYYPK KMMSSGGIVI VTNGGGSLLN EEFVVDDDFA PYYPSLRPGD TWWLLANNDD ---------- ---------- ---------- ---------- ---------- ---------- LLANN----- ---KKGGDAY KYWDDGELLV EEFVVDDDFY GLL--RRGSA Y--------- LLANN----- ---KKGGDEF KYWDDGELLK EEFIIDDDFY KLL--RRGRA YAAGGDGGNN ------- ------- KKR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLVQQEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMAAAAQQSA ATTTTPCTTT AVVVPTTLTT RDDGQQLPPT TTTAAQQQLL LSSSSLPPGG gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PVYAAAAWWT FFFSSSSAIQ QQVLSSPPPR RSSEEEKGGR TSPSSAAKVP PPAAAAWWHW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MG ---------- ---------- ---------- ---------- ---------- ------LLKN ---------- ---------- ---------- ---------- ---------- ---------- --MRRSSAAP TTTLLLLPLN NNNRPPPPPH HPPNNNLAAP SPPRRPPYTN NNPRRRCCPH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AAPFFRRRR PFFYYSSSPM MAAPDLYVCL LYYTTGGTTT ---------- ---------- ---KLLPPPP PFFYYTTTPD DAAPDIYVAL LYYVVGGTTT ---------- ---------- ---SMMPPPP PFFHHSSSPL LAAPEFYTLL LSSPPDDFFF ---------- ---------- ---TMMPPPP PFFHHSSSPL LAAPNFYTLL LSSPPDDFFF ---------- ---------- ---TLLPPPP PFFYYSSSAL LAGPKLFTML LSSPPDDAAA ---------- ---------- ---TWWPPPP PFFYYSSSPL LAAPTIYVMF FDDPPEERRR ---------- ---------- ---TWWPPPP PFFYYSSSPM MAAPKLYVRL LNNPPMMAAA ---------- ---------- ---SWWPPPP PFFYYSSSPM MAAPRLYVLL LDDPPGGRRR ---------- ---------- MKKK--CCCC PYYPPPPPLA AMGPEIYLCI IYYRRNNTTT ---------- ---------- ---------- ---------- --GPEIYLCI IYYRRNNTTT LPPGGAALII AAARRRGGLL HQQK--CCCC PYYPPPPPLA AMGPEIYLCI IYYGGNNTTT ---------- ---------- ---------- ---------- -MGPEIYLCI IYYRRNNTTT ---------- ---------- MKKN--CCCC PYYSSPPPLA AMGPEIYLCI IYYRRNNTTT -AERGAFLQQ SAAQQQPPMR TKKN--CCCC PYYSSPPPLA AMGPEIYLCI IYYRRNNTTT ---------- ---------- MKKN--CCCC PYYSSPPPLA AMG------- ---------- ---------- ---------- MKKN--CCCC PYYSSPPPLA AMGPEIYLCI IYYRRNNTTT LGKEGHTQPP WLLSSSGGQL TKKD--CCCC PYYPPPPPQA AMGPEIYLCI IYYRRNNTTT SQGCFDQNTT EHHTTTYYCT SKKN--CCCC PYYSSPPPLA AMGPEIYLCI IYYRRNNTTT ---------- ---------- MKKN--CCCC PYYSSPPPLA AMGPEIYLCI IYYRRNNTTT ARHSLQHMEE GAAAAAVVET NTTHTTKKKK PYYAAPPPLA AMGPKLYVCV VYYNNGGTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -KKS--CCCC PYYKKPPPLA AMGPEIYLCI IYYRRSSTTT -------MAA TLLDDDHHGV KVVCCCSSSS PYYAAPPPIS SMGPSLYVAV VYYAAGGTTT -------MGG TLLQQQHHAV VQQCCCSSSS PYYAAPPPLA AMGPTLYVAV VYYAAGGTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---LQQGGGG PYYAAPPPLA AMGPKLYVAV VYYTTGGTTT ---------- ---------M NAAGGGTTTT PYYAAPPPLA AMGPKLYVCV VYYNNGGTTT ---------- ---------- CKKG------ PYYAAPPPAA AIGPEVFVAP P------NNN ---------- ---------- CKKG------ PYYAAPPPAA AIGPEVFVAP P------HHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -SSKCCCCCC PYYAAPPPLA AVGPKLYVCV VQQPPNNLLL ---------- ---------- ---------- ---------- -MGPKLYTTV VQQPPNNLLL ---------- ---------- ---------- PLLII----I ILLDFLFSWL LHHGGDDIII MKRRG----- ------AALA LGGFRRFFFF DTTCCSSSPM MPTGEFYVTL LGGVVEEGGG MKRFSGPMHH FLLRRRAALV LAAAGGRRRR DTTCCSSSPM MKTGDYYVTL LGGAAEEGGG GINRDDDFII AAVVVKEYSK IHKVEEELLL PYIIINLHHH FSSALC-PNN PPNERVPPPL GVNADDDFLL AAVVVKPYGK VYKLDDDLLL PYIIIGLHHH FSSAYC-PNN PPFERVPPPL S--RDDDALL AAIIVGSYGK IHTVTTTMMM PNTTTGFHHH FSSSLS-PLL AAFERIPPPL S--KDDDALL AAIIVGPYGQ IHTVTTTMMM PNKKKGFHHH FSSALS-PLL AAFERIPPPL S--KDDDGLL AAVVVTEFGQ IHQLIIIMMM PNKKKGFHHH FSSALS-PLL AAFERIPPPI K--QDDDAII AAVVVAPYAS IGQVAAAMMM PHAAAGLHHH FSSCLC-PNN PPHERVPPPL NG-KDDDAMM CCVVVQSFGQ VGVTDDDMMM PYTTTGLHHH FSSMLC-PNN PPHERVPPPI E--RDDDALL GGLLLDGYAQ IGRVEEEMMM PNAAAALHHH FSAALC-PYY PPHERVPPPI GTEADDDYLL AAVVVKPYSQ VHRLPPPMMM PYLLLKLHHH SSSC------ SSTSRLPPPL GIEADDDYLL AAVVVKPYSQ VHRLPPPMMM PHLLLKLHHH SSSC------ SSTSRLPPPI GIEADDDYLL AAVVIKPYCQ VHRLPPPMMM PNLLLRLHHH SSSC------ SSTSRLPPPL GIEADDDYLL AAVVVKPYCQ VHRLPPPMMM PHLLLKLHHH SSSC------ IITARLPPPL GTEADDDYLL AAVVVKPYCQ VHRLPPPMMM PNLLLKLHHH SSSC------ SSTSRLPPPL GTEADDDYLL AAVVVKPYCQ VE-------- ---------- ---------- ---------- -TEADDDYLL AAVVVKPYCQ VHRLPPPMMM PNLLLKLHHH SSSC------ SSTSRLPPPL GTEADDDYLL AAVVVKPYCQ VHRLPPPMMM PNLLLKLHHH SSSC------ SSTSRLPPPL GTEADDDYLL AAVVVKPYSQ VHRLPPPMMM PYLLLKLHHH SSSC------ SSTSRLPPPF GTEADDDYLL AAVVVKPYCQ VHRLPPPMMM PNLLLKLHHH SSSC------ SSTSRLPPPL GTEADDDYLL AAVVVKPYCQ VHRLPPPMMM PNLLLKLHHH SSSC------ SSTSRLPPPL GINKDDDYLL AAVVLSPYSQ VHRLPPPVVV IHIIIGLHHH SSSC------ PPSKRLPPPL ---------- ---------- -------MMM PNTTTNLHHH SSSC------ AASVRLPPPL GINKDDDYLL AAVVVKPYSQ VHRLPPPMMM PNVVVNLHHH SSSC------ SSSVRLPPPL GIEKDDDYLL AAVVVSPYSK VHRLPPPVVV PYVVVGLHHH TSSC------ PPSERAPPPL GIEKDDDYLL AAVVLNPYSK VHRLPPPVVV PYVVVGLHHH TSSC------ PPSQRVPPPI ---------- ---------- -------MMM PFVVVGLHHH SSSC------ AASDRLPPPL GIDKDDDYLL AAVVVSPYSS VHRLPPPMMM PFVVVGLHHH SSSC------ AASDRLPPPL GINKDDDYLL GGVVVNPYSQ VHRLPPPVVV THVVVGLHHH SSSC------ PPSSRLPPPL AADGDDDAII FFVVVEDFCQ VSRVDDDVVV PHIIIGVHHH TSSC------ PPTKRVPPPL ARDGDDDAII FFVVVEEFCQ ISRVDDDVVV PNIIIGVHHH TSSC------ PPTKRVPPPL ---------- ---------- ---------- ---------- ---------- -----PRRRL DEEHDDDYLL AAVVVAPYCQ VHRTYYYTTT NSKKKHLHHH SSSCHFVP-- EEVTRLPPPL DEPHDDDYLL SSVVVEPYCQ IHRTFFFTTT NRKKKGLHHH SSSCYYVDEE TTVKRLPPPL RQYDTTTDRR KKPPMQFGGS VKDGPPPVVV KVLLLEELDD SILK------ RRVGGQLLLL MGDEDDDKLL VVIILGARGQ VNSVSSSVVV GG---RAHHH G--------- ---DRTGGGL VGDEDDDKLL VVVVAKPYGK VNTLSSSVVV GG---RAHHH S--------- ---DRAGGGL RSSSSRIYYI DTKKPPEKKI IPKSSSYYHP DISALGN-E- EEEGGGPGII LDHHHYYSFE RSSSSRIYYI DTKKPKRAAV APGTTTYYHP DISALGG-DR EEEGGGPGII FDHHHDDTFE RSSSSRIYYV DTKKPPQRRI HPATTTYYHP EVSTLGGKDT DDDGGGAPII FDCCCEETFD RSSSSRIYYI DTKKPPKKKI HPKTTTYYHP DVSTLGGKDT NNNGGGPPVV FDCCCEETFE RSSSSRIYYI DVKK-PKKKI HPATTTYYHP EVSTLGGEDT DDDGGGPPII FDCCCEETFE RSSSSRIYYI DTKKPPKFFL APETTTYYHP GVTALGN-E- KKKGGGPGII ADAAAQQSFE RSSSSHITTI DTKKPPQKKV VPETTTYYHP DISALGS-E- EEEGGGPGII FDHHHDDNLE RSSSSRIHHI DTKKPPERRI VPRTTTYYHP DVSALGS-E- DDDGGGPGVV FDHHHEESFD MSSSSRIYYV DVGGSPAKKL HAACCCVVHA SMVNTLG-LG NNNGGGKGFF VDGGGEETFE ISSSSRIYYV DVGGSPAKKL HPACCCLLHA SMISSLG-PG NNNGGGKGFF VDGGGEETFE MSSSSRIYYV DVGGSPAKKL HAACCCLLHA SMISTLG-SG NNNGGGKGFF VDGGGEETFE ISSSSRIYYV DVGGTPAKKL HPTCCCLLHP SMVSTLG-PG NNNGGGKGFF VDGGGKKTFE ISSSSRIYYV DVGGSPAKKL HPACCCLLHA SMISSLG-VG NNNGGGKGFF VDGGGEETFE ---------- ---------- -PACCCLLHA SMISSLG-VG NNNGGGKGFF VDGGGEETFE ISSSSRIYYV DVGGSPAKKL HPACCCLLHA SMISSLG-VG NNNGGGKGFF VDGGGEETFE ISSSSRIYYV DVGGSPAKKL HPACCCLLHA SMISSLG-VG NNNGGGKGFF VDGGGEETFE ISSSSRIYYV DVGGTPAKKL HAECCCLLHP TMISTLG-PG NNNGGGKGFF VDGGGEETFE ---------- ---------- ---------- ---------- ---------- ---------- ISSSSRIYYV DVGGSPAKKL HPACCCLLHA SMISSLG-VG NNNGGGKDSS LLPPP--RLE LSSGGRVYYV DTAATPTSSL HSEIIILLHA SMISCLG-KG NNNAAAAGGG FLDDDSSEFN ISSSSRIYYV DVGGTPARRI HPWCCCLLHG CMISSIG-PG NNNGGGKGFF VDGGGEETFE ISSSSRIYYV DVGGSPARRI HPWCCCLLHG CMISSLG-PG NNNGGGKGFF VDGGGEETFE VSSGGRIYYV DTKKTPSSSL HPQTTTLLHA SMISCLG-KG NNNAAAEGGG FLDDDSSDFN VSSGGRVYYV DTKKTPASSL HPTTTTLLHA SMISCIG-KG NNNAAAEGGG FLDDDSSEFN ISSGGRIYYA DTKKEPASSL YPETTTLLHA SLVSCLG-EG NNNAAAKGGG FLDDDSSDFN ISSGGRIYYA DTKKEPASSL YPDTTTLLHT -LVSCLG-EG NNNAAAKGGG LLDDDSSDFN LSSGGRVYYV DTLLKPAAAL HAETTTLLHA SMISCLG-KG NNNAAAAGGG FLDDDSSEFN NSSDDRIYYI NVEEN-KYYL EPSNNNLLHA DMISTLG-AG TTTPPPSGFF LDGGGKKTFE NSSDDRIYYV NVEEN-EYYL QPANNNLLHA DMISTLG-AG SSSPPPSGFF LDGGGKKTFE SSSGGVEGGK FVGGG----- ---------- ---------- ---------- ---------- NSSDDRIFFV DTGGTPAKKL AGKAAACCHP NMISIMG-AG NNNAAAKGDD FFDDDKKNFE NSSDDFIYYI DVVVTPKEEI VGKHHHVVHA NMISVMG-AG YYYAAAKGDD FFDDDSSDFN DGGKKRLYYV TSLLYADQQF Y-KLLLLLDP NKQDGVN-SS VVVPPPVLGG ISKKKHHENG DTTNNRIFFI DVHHSPNKKL HTDGGGVVFP GITGLSN-DH GGGGGGRTLL VNDDDDDGEY DTTSSKIFFV DVHHSPRVVL SDKGGGVVYP GITGLSN-KH GGGGGGRTLL VTNNNAAGEY PGGKKKWWWD GDDDQ----- --------LY DDDFWWWW-P NVLVEWWPPP PN----TIDG PGGRRRWWWY GPPPQ----- --------FY DDDFWWWW-P SVMIEWWPPP PR----CFEG VGGRRRWWWD GPPPQ----- --------KY DDDFWWWW-P RYMVEWWPPP PP----QFNG VGGRRRWWWD GPPPQ----- --------LY DDDFWWWW-P RYMVEWWPPP PP----QFNG IGGRRRYYYD GEEEQ----- --------KY DDDFWWWW-P RYMVEWWPPP PP----QFNG PGGRRRWWWE GPPPQ----- --------FY DDDGWWWW-G YTLVEWWPPP PD----MVDG VGGRRRWWWD GDDDQ----- --------LY DDDFWWWW-G YTLLEWWPPP PR----MVSG PGGRRRWWWE GPPPQ----- --------LY DDDFWWWW-G YTMVEWWPPP PN----MIGG VGGTTTWWWP GAAAS----- --------MY DDDFWYYY-R HVMVEWWPPP PN----VFDG VGGTTTWWWP GEEEA----- --------MY DDDFWYYY-R HIMVEWWPPP PN----VFDG VGGTTTWWWP GAAAA----- --------MY DDDFWYYY-R HVMIEWWPPP PN----VFDG VGGTTTWWWP GAAAA----- --------LY DDDFWYYY-R HVMIEWWPPP PN----VLDG VGGTTTWWWP GAAAA----- --------SY DDDFWYYY-R HVMIEWWPPP PN----VLDG VGGTTTWWWP GAAAA----- --------LY DDDFWYYY-R HVMIEWWPPP PN----VLDG VGGTTTWWWP GAAAA----- --------LY DDDFWYYY-R HVMIEWWPPP PN----VLDG VGGTTTWWWP GAAAA----- --------LY DDDFWYYY-R HVMIEWWPPP PN----VLDG VGGTTTWWWP GSSSA----- --------MY DDDFWYYY-R HVMIEWWPPP PN----VVNG ---------- ---------- ---------- ---------- ---------- ---------- CGG------- ---------- ---------- ---------- ----ISSSSS SN----LRTG VGGRRRGGGR FPPPI----- --------KR TTTHLYYYYA WLFWIQQSSS SL----FYTG VGGNNNWWWE EAAAA----- --------FY DDDFWYYY-R HVMIEWWPPP PK----AFLG VGGNNNWWWE ESSSA----- --------FY DDDFWYYY-R HVMIEWWPPP PK----AFLG VGGRRRWWWP HSSSP----- --------FY DDDFWYYY-R HTMISWWPPP PT----AFKG VGGRRRWWWP HSSSP----- --------FY DDDFWYYY-R HTMISWWPPP PK----AFQG INNRRRWWWP HSSSP----- --------FY DDDFWYYY-R HTMISWWPPP PK----AFKG INNRRRWWWP ISSSP----- --------YY HHHFWYYY-R HTMISWWPPP PK----AFKG VGGRRRWWWP HSSSP----- --------FY DDDYWYYY-R HTMISWWPPP PA----AFTG PGGTTTWWWD KTTTV----- --------FY DDDFWYYY-R RVMIEWWPPP PN----HIKG PGGTTTWWWD KVVVV----- --------FY DDDFWYYY-R RIMIEWWPPP PN----HIKG ---------- ---------- ---------- ---------- ----LRRPPP PV----TVRD LGGTTTWWWG RKKKA----- --------CY DDDYWYYY-H FVMVEWWPPP PK----LFRG CGGTTTWWWG KKKKA----- --------CY DDDFWYYY-Y FVMVEWWPPP PN----KWRG LAAKKKGGGS FEEEE----- --------LL SSSNHNNN-- RKSERPPPPP PI----MAES VTTYYYWWWT DDDDMAAVVA VVGDVDGGYY DDDIRAAA-R KVMLSFFWWW WSNNNNMMFG VTTHHHWWWT GDDDLAAIIK TTG-YDGGYY DDDVRAAA-R KLLVSFFWWW WNNNNNMMFG GG-KLEEHLL DD-YYHFWWD RRKRKRIIHH SLLENRAL-- -----EEEEL LRPPPLPTTT GG-SLEECLL EEGYYHVWWD AAKRRHLLYY AIIEHRVL-- -----EEEEV VRPPPLPTTT GG-VPEEDLL AANYYHFWWD RRARRNVVQQ TIIQHQAL-- -----EEEEV VRPPPAPVVV GG-VPEEDLL SSNYYHFWWD RRARRNVVQQ TIINHQAL-- -----EEEEV VRPPPAPVVV GG-VPEEDLL SSNYYHFWWK RRDRKNVVQQ TIINHQAL-- -----EEEEI IRPPPAPSSS GG-VPDDILL GGAYYHFWWD TTRRRHLLQQ EIIEHQVF-- -----EEEEL LRPPPAPTTT GG-LGDDELL AAGYYHVWWD YYRRRHLLQQ TLLEYQAL-- -----EEEEL LRPPPAPTTT GG-DPQQILL NNKYYHIWWD RRRRRHLLQQ ALLEHQVL-- -----EEEEL LRPPPAPAAA GGFPAHHVEE --GYYFVWWD QQRHEIIIQQ TLL-DGIP-- -LLLLEEEEI IRFFFLPSSS GGFPAHHVEE --GYYHVWWD QQRHEIIIQQ TLL-DGIP-- -LLLLEEEEI IRFFFLPDDD GGFPADDVEE --GYYHVWWD QQRHEIIIQQ TLL-DGIP-- -LLLLEEEEI IRFFFLPDDD GGFPADDVKK --GYYYVWWD QQRREIVVQQ TLL-DGIP-- -LLLLEEEEI IRFFFLPDDD GGFPADDVEE --GYYYVWWD QQHHEIVVQQ TLL-DGIP-- -LLLLEEEEI IRFFFLPDDD GGFPADDVEE --GYYYVWWD QQRHEIVVQQ TLL-DGIP-- -LLLLEEEEI IRFFFLPDDD GGFPADDVEE --GYYYVWWD QQRHEIVVQQ TLL-DGIP-- -LLLLEEEEI IRFFFLPDDD GGFPADDVEE --GYYYVWWD QQRHEIVVQQ TLL-DGIP-- -LLLLEEEEI IRFFFLPDDD GGFPADDVEE --GYYHVWWD QQRHEIVVQQ TLL-DGIP-- -LLLLEEEEI IRFFFLPAAA ---------- ---------- ---------- ---------- ---------- ---------- GGSDYPPASS --SVV----- ---------- ---------- ---------- ---------- GGALMCCLTT --SVVCLDDN IIMRVIDDEE SLL-DQGANI ILLLLCCCCL LRSSSIKNNN GGFMEEEVQQ --GYYNVWWD TTEHRRIIQQ TII-DGIP-- -LLLLEEEEI IRFFFLPDDD GGFMEDDVQQ --GYYNVWWD TTEHRLVVQQ TII-DGIP-- -LLLLEEEEI IRFFFLPDDD GGFLQHHVAA --GYYTCIIQ AARGELRRQQ TLL-TGLP-- -LLLLEEEEI IRFFFLPAAA GGFLQHHVAA --GYYHVYYS PPGGEIKKQQ TLL-KGLP-- -LLLLEEEEI IRFFFLPAAA GGFLQHHVAA --GYYHVYYS PPGGEMKKQQ LII-TGLP-- -LLLLEEEEI IRFFFLPSSS GGFLQHHVAA --GYYHVYYS PPGGEIKKQQ LII-TGLP-- -LLLLEEEEI IRFFFLPSSS GGFLQHHVQQ --GYYHVYYD PPGGELKKQQ TLL-TGLP-- -LLLLEEEEV VRFFFLPSSS GGFPAHHVGG --GYYHIFFE DDSKKYLLQQ TIIPLGLP-- -LLLLEEEEV VRFFFLPTTT GGFPAHHVPP --GYYHIFFE DDTKKHLLQQ TIIPRGLP-- -LLLLEEEEV VRFFFLPTTT DDELKCCQPP --PVVRVYY- ---------- ---------- ---------- ---------- GGYPTDDCDD RRTYYNFYYR QQERELFFQQ TII-DGTP-- -LLLLEEEEI IRFFFLPRRR GGWNVDDLEE MMSYYNFYYK SSTQTLYYQQ TII-DGTP-- -LLLLEEEEI IRFFFLPKKK SSSSFLLKKK GGPKKAEVVL ---------- ---------- ---------- ---------- GGQLQDDAEE MMKFFVQWWD HHTRQPKKKK VFFAP----- -LLLLEEEEI IRFFFPSNNN GGKLADDPEE MMKFFVTWWD HHTKQPKKKK VFFAP----- -LLLLEEEEI IRCCCAEAAA KLLGIINMMM VLKKDDLLSS SSSSSIWWWW FFF-EEDNAE EIPAEEPPEE --NLLPEKAP KLLGVVNVVV LTKKDDLLSS SSSSSIWWWW FFF-EEDQAE DIEAQQPPEE --PLLPPKMP REEGVVGVVV VTTTNNLLEE EEGGSIWWWW WWW-EEGHVK TIPAEEPPTT DDELLPPQAP REEGVVGVVV VTTTNNLLEE EEAASIWWWW WWW-EEGHAE TIPPEEPPPP EEKLLPPQAP KDDGCCGVVV VTTTNNLLQQ QQGGAIFFFW WWWKDDDEAK TIDPVVPPDD DDDLLPDKAP KAAGVVNCCC ILKKDDLLSS SSSSSIWWWW YYY-DDKAVR EIPAEEAADD DDQLLPPKAP KAAGMMNCCC VLKKDDLLSS SSAASIWWWW YYY-DDNHLK DIPAEEPPSS DDQLLPPKAP RTTGVVGVVV VLEEDDLLSS SSAASVWWWW HHH-QQNGIR EIPAEEPPEE DDQLLPPKAP ATTGVVGCCC LSNNIIQQRR RRFFYKNNNE GGG------- WSVEKKVVQQ PPSKKKVWEP ATTGVVGCCC LSNNIIQQRR RRFFYKNNNG GGG------- WSVEKKVVQQ PPSKKKVWEP AAAGVVGCCC LSTTIIQQRR RRFFYKNNNG GGG------- WSVEKKVVQQ PPPKKKVWEP AAAGVVGCCC LSTTIIQQRR RRFFFKNNND GGG------- WSAQKKVVQQ PPPKKKVWEP AAAGVVGCCC LSTTIIQQRR RRFFYKNNNG GGG------- WSVEKKVVQQ PPPKKKVWEP AAAGVVGCCC LSTTIIQQRR RRFFYKNNNG GGG------- WSVEKKVVQQ PPPKKKVWEP AAAGVVGCCC LSTTIIQQRR RRFFYKNNNG GGG------- WSVEKKVVQQ PPPKKKVWEP AAAGVVGCCC LSTTIIQQRR RRFFYKNNNG GGG------- WSVEKKVVQQ PPPKKKVWEP ASSGVVGCCC LSTTIIQQRR RRFFYKNNNG GGG------- WSVEKKVVEE PPPKKKVWEP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- INNDDDVVVV VFSSGGRRGG GGGGSDPPPA YYY------- VVLKRRKKDD YYYAAVVFSS AAAGVVGCCC LSTTVVFFRR RRFFYKEEED GGG------- WAAEKKVVKK PPSKKKVWEP ADDGVVGCCC LSSSIIFFRR RRFFYKEEED GGG------- WAAEKKVVQQ PPSKKKVWEP KDDGVVGSSS LSNNMMIIRR RRFFFKTTTD GGG------- WSHELLAAPP KKPLLKVWEP KDDGVVGSSS LSNNMMIIRR RRFFFKTTTD GGG------- WNHEIIVVSS EEPLLKVWEP KDDGVVGSSS LSNNMMIIRR RRFFFKNNND DDD------- WSYEIIVVSS KKPLLKVWEP KDDGVVGSSS LSNNMMIIRR RRFFFKNNND EEE------- WSHEVVVVSS KKPLLKVWEP KDDGVVGCCC LSNNMMVVRR RRFFFKTTTD GGG------- WSHEVVAASS KKPLLKVWEP SEEAVVGCCC LSGGIIFFRR RRIIHPVVVE NNN------- HAATLLVVFF PPSKKKVWEP SEEAVVGCCC LSAAIIFFRR RRIIHPDDDK NNN------- QTASLLVVTT PPSKKKVWDP ---------- ---------- ---------- ---------- ---------- ---------- ENNGVVGCCC FXXXXXXXXX XXXXX----- ---------- ---------- -----QGGMG KAAGVVGCCC LAKKVVFFHH HHFFKKKKKD SSS------- AKKVIIDDPP KKLVVDTGDG ---------- ---------- ---------- ---------- ---------- ---------- ANNASSTTTT LSQQLLWWLL LLIIYEDDDA GGG------- --------EE QQAKKAVIAI HNNCTTSTTT LSQQLLWWLL LLIIYEDDDE GGG------- --------EE QQAKKAVIAV PPPPPLLTDD DDSSLLDFLL LLWIVVVRRQ IINVVLLLTG KVVKKFRADD DDHH------ PPPPPLLTDD DDSSLLDFLL VLWLLLLRRQ IINRRLLLAG RVVKKYREPP PPHH------ PPPPPLLTDD DDSSLLDFLL VCWTMMMRRQ VVDVVLLLAG SVVRRARAPP PPHH------ PPPPPLLTDD DDSSMMDFLL VCWTMMMRRQ VVDKKLLLAG SVVHHARTPP PPHH------ PPPPPLLTDD DDSSLLDYLL VCWLMMMHHQ VVDVVLLLTG KVVEEVKTPP PPHH------ PPPPPLLTDD DDSSMMDFLL VCWTLLLLLQ VVDKKLLLTG KVVRRVRATT TTHHG----- PPPPPLLTDN NNSSVVDFLL VCWTLLLHHQ VVDRRLLLTG KVVQQVRAGG GGHH------ PPPPPLLTDN NNSSLLDFLL VCWTLLLRRQ VVDRRHHHTG SVVRRVKAAA AAHH------ GGGGGLLTDL LLSSLLDFLL FNWHIIIRRQ IINRRLLLTG QIIFFIRGGG GGSSQ-DDQE GGGGGLLTDL LLSSLLDFLL FNWHIIIRRQ IINRRLLLTG QIIFFIKGGG GGSSQ-DDQE GGGGGLLTDL LLSSLLDFLL FNWHLLLRRQ IIDRRLLLTG QLLFFIKGGG GGPPQ-DDQE GGGGGLLTDL LLSSLLDFLL FNWHIIIRRQ VVDRRLLLTG QLLFFIKDGG GGPPQ-DDQE GGGGGLLTDL LLSSLLDFLL FNWHLLLRRQ IIDRRLLLTG QLLFFIKGGG GGPPQ-DDQE GGGGGLLTDL LLSSLLDFLL FNWHLLLRRQ IIDRRLLL-- ---------- ---------- GGGGGLLT-- ---------- ---------- ---------- ---------- ---------- GGGGGLLTDL LLSSLLDFLL FNWHLLLRRQ IIDRRLLLTG QLLFFIKGGG GGPPQ-DDEE GGGGGLLTDL LLSSLLDFLL FNWHMMMRRQ IIDRRLLLVG QIIFFIKGGG GGPPQ-DDQE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NNNNNEEPPW WWFFFFDLII FS-------- ---------- ---------- ---------- GGGGGLLTDL LLSSLLDFLL FNWHIIIRRQ IIDKKLLLVG QIIFFIRGGG GGPPT-DDKD GGGGGLLTDL LLSSLLDFLL FNWHIIIRRQ IIDKKLLLVG QIIFFIRGGG GGPPT-DDKE GGGGGLLTDL LLSSLLDFLL FNWHIIIRRQ IIDVVLLLTG QLLWWIKGSS SSPPA-EEDG GGGGGLLTDL LLSSLLDFLL FNWHIIIRRQ IIDKKLLLTG QVVWWIKGSS SSPPV-DDDG GGGGGLLTDL LLSSLLDFLL FNWHIIIRRQ IIDVVLLLTG QIIWWLKGSS SSPPK-EEDG GGGGGLLTDL LLSSLLDFII FNWHIIIRRQ IIDVVLLLTG QIIWWLKGSS SSPPK-EEDG GGGGGLLTDV VVSSLLDYLL LNWHIIIRRQ IIDVVLLLAG QVVWWLKGSS SSEEV-EEDD AAAAALLTDL LLSSMMDFLL VCWHIIIRRQ IIDKKLLLNS QVVYYVTESS SSNNK-GGEK AAAAALLTDL LLSSMMDFLL VCWHIIIRRQ IIDKKLLLNS QVVFFISETT TTTTK-EEDH ---------- ---------- ---------- ---------- ---------- ---------- GGGGGMMTDL LLSSLLDYLL FNWHVVVRRQ IIDRRLLLTG QVVFFIRDAA AAPPR-DDPE GGGGGMMSDI IISSLLDFLL VCWHVVVRRQ IIDKKLLLTG QLLFFISDLL LLPPVEDDKE ---------- ---------- ---------- ---------- ---------- ---------- PPPPPLLVDS SSAAAADTLL ISFDTTTRRL IIDFFQQQIY EKKVVV---- ---------- PPPPPLLVDS SSSSNNDRLL VTFDTTTRRL IIDRRQQQVY EKKTTV---- ---------- ---------- -----AAGGK TQMMLLEEEI SRRRRVYYVT NSSSTTWWDQ FPPEKKVVVK ---------- -----SSGGE TQMMIISSSV SRRRRVYYIT NSSSSSWWNQ FPP-RRAAAK ---------- -----NNGGT AQMMVVEEEI SRRRRVYYWT NSSSTTWWDQ FPPDPPVVVL ---------- -----NNGGA AQMMVVEEEI SRRRRVYYWT NSSSTTWWDQ FPPDPPVVVM ---------- -----NNGGT GQMMVVEEEI SRKKRVYYWT NSSSTTWWDQ FPPGGGVVVM ---------- --AAAKKNNA NQMMVVEEEI SRRRRVYYFT NSGGAAVVDQ FPPEDDVVVK ---------- --AAATTSSE NQMMVVEEEI SRRRRVYYFT NSRRAAWWDQ FPPDKKVVVK ---------- -----AASSP NQMMVVEEEV SRRRRVYYFS NSAASSWWDQ FPPVRRAAAK ELLTTCPPPP LLVVVKKGGR PQMMIIQQQL SLKKRLYYAT TSSSDDWWDQ F--PIISSSV ELLTTCPPPP LLVVVKKGGR PQMMIIQQQL SLKKRLYYVT TSSSAAWWDQ F--PIISSSV ELLKKSPPPP LLVVVKKGGK PQMMIIQQQL SLKKRLYYVT TSSSAAWWDQ F--PIISSSV ELLDDSPPPP LLVVVKKGGQ AQMMIIQQQL SLKKRLYYVT TSSSAAWWDQ F--PIISSSV ELLKKSPPPP LLVVVKKGGR AQMMIIQQQL SLKKRLYYIT TSSSAAWWDQ F--PIISSSV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ELLKKSPPPP LLVVVKKGGR AQMMIIQQQL SLKKRLYYIT TSSSAAWWDQ F--PIISSSV ELLKKSPPPP LLVVVKKGGR PQMMIIQQQL SLKKRIYYVT TSSSDDWWDQ F--PIISSSV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DLLEECPPPP VVVVVKKGGK PQMMIIQQQL SLKKRLYYVT NSSSKKWWDQ F--PIISSSV ELLEECPPPP VVVVVKKGGI PQMMIIQQQL SLKKRIYYVT SSSSIIWWDQ F--PLLAAAV GKKTTWSSVV PPIIIQQGGK RQMMIIQQQL TLKKRLYYVT NSSSAAWWDQ F--PVVSSSH GEETTWSSVV PPIIIQQGGK RQMMIIQQQL SLKKRLYYVT NSSSAAWWDQ F--PVVSSSH GNNSSFFFVV PPIIIKKGGS RQMMIIQQQL SLKKRLYYAT NSSSAAWWDQ F--PMMSSSH GNNTTFFFVV PPIIIKKGGS RQMMIIQQQL SLKKRLYYAT NSSSAAWWVS F--PMMSSSH DKKEEEYYVV PPVVVKKGGR RQMMIIQQQL SLKKRIYYVT NSSSRRWWDQ FGGQVVSSSH K-----IIAA LLVVVKKGGK EQMMLLQQQL SLKKRLYYVT TSKKKKWWDQ F--PVVAAAT HDD---IIAA LLVVVKKGGQ EQMMLLQQQL SLKKRLYYVS TSKKKKWWDQ F--PVVAAAT ---------- ---------- -AKKIIQQQL SVKKRLYYVT NSSSTTWWDQ F--PVVSSSV ELLKKEPPPP VVLLLKKGGR LQMMLLQQQL SLRRRLYYVS SSSSPPWWDQ F--PVVGGGT ELLKKEPPAA RRVVVKKGGR EQMMLLQQQL SLKKRLYYVS SSSSPPWWDQ F--PVVGGGH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMVVSSSQ SWKKRVYYFS SSAANNWWD- ------KKKD ---------- ---------- --MMVVSSSS SWQQRLYYYT SSAANNWWD- ------KKKD LAN------P SIDKKEFFFF VVDDFF---- AARRRSSSSS HQQVVLSGGD SSSSSYP--- VVN------P ELEKKEFFFF VVDDFF---- AARRRAAAAA HQQVVLWGGD SSTSSFP--- AAG------P DLADDDYYYY VVEEFFG--- YYRRRAAAAA HQQIILEGGD SSTSSFPSSV AVG------G NLDKKDYYYY VVSSFFG--- YYRRRAAAAA HQQIILEGGD SSTSSFPSSV AVG------E NLDKKDFFFF VVDDFFG--- YYRRRSSSSS HQQIILEGGD SSTSSFPSSV LAG------P NFDPPKFFFF LLEEWWG--- HHRRRPPPPP HQQVVLQGGD SSSSSYP--- VVN------P DFDPPNFFFF VVDDFF---- QQRRRVVVVV HQQIILQGGD SSSSSYP--- AAD------P GLDPPGFFFF TTEEVVG--- LLRRRPPPPP HQQIILEGGD SSSSSYPSS- MQVDDVVVDV NLNPPNFFFF VVDDFFELLP AALLLAAAAA HEELLYPGGD SSSIIW---- MQIDDVVVDA NLNPPNFFFF VVDDFFELLP AALLLAAAAA HEELLYPGGD SSSIIW---- MQIDDVVVDV KLNPPNFFFF VVDDFFELLP AALLLAAAAA HEELLYPGGD SSSIIW---- MQIDDVVVDV KLNPPNFFFF VVDDFFELLP AALLLAAAAA HEELLYPGGD SSSIIW---- MQVDDVVVDV KLNPPNFFFF VVDDFFELLP AALLLAAAAA HEELLYPGGD SSSIIW---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MQVDDVVVDV KLNPPNFFFF VVDDFFELLP AALLLAAAAA HEELLYPGGD SSSIIW---- MQIDDVVVDV KLNPPNFFFF VVDDFFELLP AALLLAAAAA HEEIIYPGGD TTSIIW---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MQIDDVVVDE KLNPPNFFFF VVDDFFEGGP VVLLLAAAAA HEELLYPGGD SSSIIW---- MQIDDVVVDK KLNPPNFFFF VVDDFFEDDP VVLLLAAAAA HEEIIYPGGD TTSIIW---- IQIDDVVVDE KINPPNFFFF VVDDFFEDDP AALLLAAAAA HEEMMYPGGD TTSIIW---- IQIDDVVVDE NINPPNFFFF VVDDFFEDDP SSLLLAAAAA HEEMMYPGGD TTSIIW---- IQIDDVVVDE KINPPNFFFF VVDDFFEEEP AALLLAAAAA HEEMMYPGGD TTSIIW---- IQIDDGGGDE KINPPDFFFF VVDDFFEDDP SSLLLAAAAA HEEMMYPGGD TTSIIW---- MQIDDVVVDE KINPPNFFFF VVDDFFEEEP SSLLLAAAAA HEEMMYPGGD TTSIIW---- MQVNNIIIDE SINRRDFFFF IIDDFFIGGP YYLLLAAAAA HEEMMYPGGD TTSIIW---- MQIDDVVVDI TINKKNFFFF IIDDFFVGGP YYLLLAAAAA HEEMMYPGGD TTSIIW---- MQIDDVVVDE KVNKKNFFFF VVDDFFENNP CCLLLAAAAA HDDIIFPCGD TTSIIL---- IQLDDIIIDE NLNEENFFFF VVDDFFEYYP GGLLLPPPPP HEEMM----- ---------- ILIDDVVVDV NLNEEDFFFF VVDDFFEYYP SSLLLPPPPP HEEMMYPGGD TTSIIWNDDA ---------- ---------- ---------- ---------- ---------- ---------- DQYLLKKKAN WLVEEDFFFF VVDDFFLLL- --RRRAAAAA HIIMMFGSSA YYS------- DQFLLKKKLY WLKEEQFFFF IIDDFFELL- --RRRPPPPP HQQMMFGARA YYAPPAGNNR ------- ------- RRR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- VVVVEEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NNSAAKAKKE AATPPPTTAV VTTTTTAALA ADDDDGASSL PRRQQLLSLL LPPSSSVIKK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AYQATTTFFF SSSAAAASSP RRREKGGRRR KTTTRRSPGV VEEEISSSSS SAAKQQVVPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MASPPPTTT LLPPPTTPTP HHHNLAAPPP ASSSPPPPRP PLLLTRRLLL LVPYRRTTNN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----AVFFR DPPPMAAPDD YAACCCLYTG ---------- ---------- ---------- ------ALLP DPPPDAAPDD YAAAAALYVG ---------- ---------- ---------- ------MMMP DPAPLAAAEE YLLLLLLSPS ---------- ---------- ---------- ------MMMP DPAPLAAANN YLLLLLLSPS ---------- ---------- ---------- ------MLLP DPPALAAVKK FLLMMMLSPS ---------- ---------- ---------- ------AWWP DPPPLAAPTT YAAMMMFDPK ---------- ---------- ---------- ------VWWP DPPPMAAAKK YVVRRRLNPN ---------- ---------- ---------- ------AWWP DPPPMAARRR YAALLLLDPE ---------- ---------- ---------- --AAAKT--C GPTLAMMREE YPPCCCIYRG ---------- ---------- ---------- ---------- -------REE YPPCCCIYRG AAVHLLPPPP KHHHGVIIII AAAAALLLGG -ASSSQG--C GPSLAMMREE YPPCCCIYGG ---------- ---------- ---------- ---------- -----MMREE YPPCCCIYRG ---------- ---------- ---------- --AAAKG--C GPTLAMMREE YPPCCCIYRG ------AAEE AEEEGTQQQQ SSSSAMMRII ASAAAKG--C GPTLAMMREE YPPCCCIYRG ---------- ---------- ---------- --AAAKG--C GPTLAMM--- ---------- ---------- ---------- ---------- --AAAKG--C GPTLAMMREE YPPCCCIYRG ---MLLGGKK EPPPGAPPPP WWWWLQQLQQ EDAAAKG--C GPTQAMMREE YPPCCCIYRG ---KSSQQGG LGGGFTTTTT EEEEHCCTVV FTPPPKG--C GPTLAMMREE YPPCCCIYRG ---------- ---------- ---------- --AAAKG--C GPTLAMMREE YPPCCCIYRG RRLPAARRHH LVVVLIEEEE GGGGAEETAA AAGGGTCTTK GPTLAMMRKK YTTCCCVYNG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMMKG--C GPSLAMMREE YPPCCCIYRG ---------- ------AAAA TTTTLGGVNN EKSSSVGCCS GPSISMMRSS YTTAAAVYAG ---------- ------GGGG TTTTLAAVSS EKNNNQGCCS GPSLAMMRTT YTTAAAVYAG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MQQG GPTLAMMSKK YTTAAAVYTG ---------- ---------- -------MAA AAGGGACGGT GPTLAMMRKK YTTCCCVYNG ---------- ---------- --------SS PNGGGKH--- GPSAAIIREE FTTAAAP--A ---------- ---------- --------PP --PPPKH--- GPSAAIIREE FTTAAAP--A ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----SSCCC GPTLAVVVKK YVVCCCVQPD ---------- ---------- ---------- ---------- -----MMRKK YVVTTTVQPD ---------- ---------- ---------- ---------- MPT-ILLDFF FNNWWWLHGR ----MMKKRR EFFFG----- -----LLAGG -AAAAGPRRF ADQPMPPQEE YWWTTTLGVM ----MMKKRR IVVVSSHHHH FFFFLLLVGG LAAAAAPGGR ADAPMKKQDD YWWTTTLGAV GGNNNAADDF VVVDNNNPEE TTSSKVEEEI DDELHHHHGW WCSSL-GPPP FIIIPPLLSR GGNNNPPDDF VVVDDDDPPP TTGGKLDDDI DDELHHHHGW WCSSY-APPP YIIIPPLLSR SS---PPDDA VIIDKKKPSS TTGGTVTTTT DDEFHHHHGW WCSSL-TAAA FIIIPPLLSR SS---PPDDA VIIDKKKPPP TTGGTVTTTK DDEFHHHHGW WCSSL-AAAA YIIIPPLLSR SS---PPDDG VVVDDDDPEE KKGGQLIIIK DDEFHHHHGW WCSSL-TAAA YIIIPPIISR KK---PPDDA VVVDDDDPPP RRAAQVAAAA DDELHHHHGW WCSSL-APPP YVVVPPLLSR NN---PPDDA VVVDDDDSSS TTGGVTDDDT GGELHHHHGW WCSSL-APPP YVVVPPIISH EE---PPDDA VLLDDDDPGG TTAARVEEEA DDELHHHHGW WCSAL-APPP YIIIPPIISR GGEEEPPDDY TVVDDDDPPP QQSSRLPPPL DDELHHHHGW WCSS--FSSS KIIIPPLLSR GGEEEPPDDY TVVDDDDPPP HHSSRLPPPL DDELHHHHGW WCSS--FSSS KIIIPPIISR GGEEEPPDDY TVVDDDDPPP QQCCRLPPPL DDELHHHHGW WCSS--FSSS KMMMPPLLSR GGEEEPPDDY TVVDDDDPPP QQCCRLPPPL DDELHHHHGW WCSS--YIII KVVVPPLLSR GGEEEPPDDY TVVDDDDPPP QQCCRLPPPL DDELHHHHGW WCSS--FSSS KVVVPPLLSR GGEEEPPDDY TVVDDDDPPP QQCC------ ---------- ---------- ---------- --EEEPPDDY TVVDDDDPPP QQCCRLPPPL DDELHHHHGW WCSS--FSSS KVVVPPLLSR GGEEEPPDDY TVVDDDDPPP QQCCRLPPPL DDELHHHHGW WCSS--FSSS KVVVPPLLSR GGEEEPPDDY TVVDDDDPPP QQSSRLPPPL DDELHHHHGW WCSS--FSSS KVVVPPFFSR GGEEEPPDDY TVVDDDDPPP QQCCRLPPPL DDELHHHHGW WCSS--FSSS KVVVPPLL-- GGEEEPPDDY TVVDDDDPPP QQCCRLPPPL DDELHHHHGW WCSS--FSSS KVVVPPLLSR GGNNNLLDDY TVVDDDDPPP TTSSRLPPPI DDKLHHHHGW WCSS--HPPP FIIIPPLLGR ---------- ---------- ---------T DDELHHHHGW WCSS--YAAA KIIIPPLLSR GGNNNPPDDY TVVDDDDPPP SSSSRLPPPV DDELHHHHGW WCSS--YSSS KIIIPPLLSR GGEEEPPDDY TVVDDDDPPP TTSSRLPPPV DDELHHHHGW WCSS--HPPP FIIIPPLLGR GGEEEPPDDY TVVDDDDPPP TTSSRLPPPV DDELHHHHGW WCSS--HPPP FIIIPPIIGR ---------- ---------- ---------V DDELHHHHGW WCSS--HAAA YVVVPPLLGR GGDDDPPDDY TVVDDDDPPP SSSSRLPPPV DDELHHHHGW WCSS--HAAA YVVVPPLLGR GGNNNPPDDY TVVDDDDPPP TTSSRLPPPV DDELHHHHGW WCSS--HPPP FIIIPPLLGR AADDDPPDDA TVVDNNNPDD TTCCRVDDDI DDEVHHHHGW WCSS--HPPP HIIIPPLLDR AADDDPPDDA TVVNNNNPEE TTCCRVDDDI DDEVHHHHGW WCSS--HPPP HIIIPPLLDR ---------- ---------- ---------- ---------- ---------- -VVVRRLLGV DDEEEGGDDY TVVDDDDPPP TTCCRTYYYK NNELHHHHGW WCSSHVGEEE RVVVPPLLDR DDPPPGGDDY TVVDDDDPPP TTCCRTFFFK DDELHHHHGW WCSSYVSTTT RVVVPPLLDF RRYYYIITTD NPPRVVVGFF LLGGDGPPPL DDKELLLDQP PRIL---RRR QLLLLLLLKR MMDDDQQDDK TIIDRRRPAA TTGGSVSSS- NNEAHHHHGF F--------- FWWWGGLLNR VVDDDQQDDK TVVDNNNPPP QQGGTLSSS- NNEAHHHHDF F--------- YWWWGGLLSK IYYYIIIDTP PPRPKIIIKK EEEVVSSGYS SLLVVHHCGP PDDAIIYYSA G--EG--EEE IYYYIVVDTP PKRPAVAAKK EEEARTTGYT TYYVVHHCGP PDDAIIYYSA G--DGRREEE IYYYVIIDTP PPTARIHHKK EEEIKTTGYS SPPVVHHCGP PEEGIIYYST GGGDGTTDDD IYYYIIIDTP PPTAKIHHKK EEEVKTTGYS SPPIIHHCGP PDDGIIYYST GGGDGTTNNN IYYYIVVDV- -PLAKIHHKK EEEVKTTGYS SPPIIHHCGP PEEGIIYYST GGGDGTTDDD IYYYILLDTP PPLPFLAAKK EEELRTTGYS SPPVVHHCGP PGGGIIYYTA G--EG--KKK ITTTILLDTP PPTPKVVVKK DDDLRTTGYA APPVVHHCGP PDDGIIYYSA G--EG--EEE IHHHIVVDTP PPRPRIVVKK EEELRTTGYS SPPIIHHCGP PDDGVVYYSA G--EG--DDD IYYYVVVDVS SPRPKLHHKK EEEIKCCNVS STTSSHHCLA ASSGEEVVVN L--LQGGNNN IYYYVVVDVS SPRPKLHHKK EEEIKCCNLG GLLSSHHCLA ASSGEEVVIS L--PQGGNNN IYYYVVVDVS SPRPKLHHKK EEEIKCCGLG GVVSSHHCLA ASSGEEVVIS L--SKGGNNN IYYYVVVDVT TPRPKLHHKK EEEIKCCNLG GFFSSHHCLP PSSGEEVVVS L--PEGGNNN IYYYVVVDVS SPRPKLHHKK EEEIKCCELA ALLSSHHCLA ASSGEEVVIS L--VKGGNNN ---------- ---------- ---IKCCELA ALLSSHHCLA ASSGEEVVIS L--VKGGNNN IYYYVVVDVS SPRPKLHHKK EEEIKCCELA ALLSSHHCLA ASSGEEVVIS L--VKGGNNN IYYYVVVDVS SPRPKLHHKK EEEIKCCELA ALLSSHHCLA ASSGEEVVIS L--VKGGNNN IYYYVVVDVT TPRPKLHHKK EEEIKCCGLG GPPSSHHCLP PTTGEEVVIS L--PKGGNNN ---------- ---------- ---------- ---------- ---------- ---------- IYYYVVVDVS SPRPKLHHKK EEEIKCCELA ALLSSHHCLA ASSGEEVVIS L--VKGGNNN VYYYVVVDTT TPRPSLHHKK EEEINIIGLG GPPSSHHCLA ASSGDDIIIS L--KEGGNNN IYYYVVVDVT TPRPRIHHKK EEEVKCCGLA ALLSSHHCLG GCCGEEIIIS I--PYGGNNN IYYYVVVDVS SPRPRIHHKK EEEVKCCGLA APPSSHHCLG GCCGEEIIIS L--PCGGNNN IYYYVIIDTT TPRPSLHHKK DDDIKTTGLA APPSSHHCLA ASSGEELLIS L--KDGGNNN VYYYVIIDTT TPRPSLHHKK EEEIKTTGLA APPSSHHCLA ASSGEEIIIS I--KDGGNNN IYYYAIIDTE EPRPSLYYKK DDDIKTTGLA APPAAHHCLA ASSGEEIIVS L--EEGGNNN IYYYAIIDTE EPRPSLYYKK DDDIKTTGLA APPAAHHCRT T--GEEIIVS L--EEGGNNN VYYYVVVDTK KPRPALHHKK EEEIKTTGLG GPPSSHHCLA ASSGEEIIIS L--KEGGNNN IYYYIIINVN N-RIYLEEHH EEELLNN-LS SPPSSHHCLA ADDGNNIIIS L--ANGGTTT IYYYVIINVN N-RIYLQQHH EEELLNN-LS SPPSSHHCLA ADDGNNIIIS L--ADGGSSS EGGGKVVFVG G--------- ---------- ---------- ---------- ---------- IFFFVIIDTT TPRPKLAAKK EEEVGAADCT TPPTTHHCLP PNNGNNIIIS M--AEGGNNN IYYYILLDVT TPRPEIVVKK DDDVSHHNVT TPPTTHHCLA ANNGNNIIIS M--AEGGYYY LYYYVTTTSY YAWKQFYYPP ---LFLLVLA ASSAADDYQP PNNTAALLQD V--SLSSVVV IFFFIFFDVS SPSPKLHHKK DDDVSGGGVV VPPFFFFALP PGGSMMMMTG S--DDHHGGG IFFFVFFDVS SPAPVLSSKK TTTVSGGGVV VPPLLYYALP PGGRMMLLTG S--KDHHGGG PGGLLDFLGG GGKEIGDDQ- ---------- -------LLA AYYDFWNNN- -PPELLVEWA PGGFLDFIGG GGREVGPPQ- ---------- -------FFA AYYDFWNNN- -PPGMMIEWT APGFMDFLGG GGREIGPPQ- ---------- -------KKH HYYDFWNNN- -PPDMMVEWA PPGFMDFLGG GGREIGPPQ- ---------- -------LLH HYYDFWNNN- -PPDMMVEWA PPGFLDFLGG GGREMGEEQ- ---------- -------KKH HYYDFWNNN- -PPDMMVEWG PGGALDFLGG GGREVGPPQ- ---------- -------FFA AYYDGWHHH- -GGDLLVEWG PGGFLDLLGG GGREIGDDQ- ---------- -------LLH HYYDFWHHH- -GGDLLLEWG PGGFMDFLGG GGREVGPPQ- ---------- -------LLA AYYDFWHHH- -GGDMMVEWG KGSVLDFKGG GGTEKGAAS- ---------- -------MMG GYYDFYQQQ- -RRNMMVEWA KGGVLDFKGG GGTEKGEEA- ---------- -------MMG GYYDFYQQQ- -RRNMMVEWA KGGVLDFKGG GGTEQGAAA- ---------- -------MMG GYYDFYQQQ- -RRNMMIEWA KGGVLDFKGG GGTEQGAAA- ---------- -------LLG GYYDFYQQQ- -RRNMMIEWA KGGVLDFKGG GGTERGAAA- ---------- -------SSG GYYDFYQQQ- -RRNMMIEWA KGGVLDFKGG GGTERGAAA- ---------- -------LLG GYYDFYQQQ- -RRNMMIEWA KGGVLDFKGG GGTERGAAA- ---------- -------LLG GYYDFYQQQ- -RRNMMIEWA KGGVLDFKGG GGTERGAAA- ---------- -------LLG GYYDFYQQQ- -RRNMMIEWA KGGVLDFKGG GGTERGSSA- ---------- -------MMG GYYDFYQQQ- -RRNMMIEWA ---------- ---------- ---------- ---------- ---------- ---------- KDGLLLLSGG GG-------- ---------- ---------- ---------- -------ISA AGNFLLFKGG GGRSNFPPI- ---------- -------KKE ERRTHYEEEY YAAGFFWIQC KGGVLDFKGG GGNEAEAAA- ---------- -------FFG GYYDFYQQQ- -RRNMMIEWG KGGVLDFKGG GGNEVESSA- ---------- -------FFG GYYDFYQQQ- -RRNMMIEWG EGNFLLFKGG GGREKHSSP- ---------- -------FFG GYYDFYQQQ- -RRNMMISWG EGNFLLFKGG GGREKHSSP- ---------- -------FFG GYYDFYQQQ- -RRNMMISWG KGNFLLFKNN NNREKHSSP- ---------- -------FFG GYYDFYQQQ- -RRKMMISWG KGNLLLFKNN NNREKISSP- ---------- -------YYG GYYHFYQQQ- -RRKMMISWG AGNFLLFKGG GGREKHSSP- ---------- -------FFG GYYDYYQQQ- -RRKMMISWG SGNLLDFKGG GGTPAKTTV- ---------- -------FFN NYYDFYQQQ- -RRNMMIEWG SGNLLDFKGG GGTPAKVVV- ---------- -------FFN NYYDFYQQQ- -RRNMMIEWG ---------- ---------- ---------- ---------- ---------- -------LRG KG-FEFFVGG GGTSRRKKA- ---------- -------CCG GYYDYYQQQ- -HHNMMVEWG KG-FLFFIGG GGTTKKKKA- ---------- -------CCG GYYDFYQQQ- -YYDMMVEWG VLNITSNSAA AAKEAFEEE- ---------- -------LLQ QLLSNNNNN- ---ESSERPD RTAVYNEATT TTYMPDDDMA AAAVVAVVVG GGAAVVDYYG GYYDIALLL- -RRNMMLSFT RTAVYTEATT TTHIPGDDLA AAAIIKTTTG GGKKYYDYYD DYYDVALLL- -RRNLLVSFT AAVPNTIDGL KEHHHHKKKK RRYYYYGGGI HHDDLLKKKR KKKKISLLLG GNNNRRMMM- TTVPRCFEGF SECCCCKKKK AAYYYYGGGL HHDDLLKKKR RRRRLAILLG GHHHRRMMM- AALPPQFNGI VEDDDDLLLL KKYYYYGGGL HHDDLLAAAR RRRRVTILLG GHHHQQMMM- AALPPQFNGI VEDDDDLLLL KKYYYYGGGL HHDDLLAAAR RRRRVTILLG GHHHQQMMM- GGLPPQFNGI VEDDDDLLLL KKYYYYGGGI HHKKLLDDDR KKKKVTILLG GHHHQQMMM- GGTPDMVDGL VDIIIILLLL RRYYYYGGGL HHDDLLRRRR RRRRLEIFFG GHHHQQLLL- GGTPRMVSGV LDEEEELLLL KKYYYYGGGL HHDDLLRRRR RRRRLTLLLG GYYYQQMMM- GGTPNMIGGL DQIIIILLLL GGYYYYGGGL HHDDLLRRRR RRRRLALVVG GHHHQQMMM- AAAPNVFDGN PHVVVVAAAA LLYYYYGGGI FFDDWWRRRH EEEEITLMMT TDDDGGLLL- AAAPNVFDGN PHVVVVAAAA LLYYYYGGGI HHDDWWRRRH EEEEITLMMK KDDDGGLLL- AAAPNVFDGN PDVVVVAAAA LLYYYYGGGL HHDDWWRRRH EEEEITLLLQ QDDDGGLLL- AAAPNVLDGN PDVVVVAAAA LLYYYYGGGL YYDDWWRRRR EEEEVTLLLQ QDDDGGLLL- AAAPNVLDGN PDVVVVAAAA LLYYYYGGGL YYDDWWHHHH EEEEVTLLLK KDDDGGLLL- AAAPNVLDGN PDVVVVAAAA LLYYYYGGGL YYDDWWRRRH EEEEVTLLLK KDDDGGLLL- AAAPNVLDGN PDVVVVAAAA LLYYYYGGGL YYDDWWRRRH EEEEVTLLLK KDDDGGLLL- AAAPNVLDGN PDVVVVAAAA LLYYYYGGGL YYDDWWRRRH EEEEVTLLLK KDDDGGLLL- AAAPNVVNGN PDVVVVAAAA LLYYYYGGGL HHDDWWRRRH EEEEVTLMMP PDDDGGHHH- ---------- ---------- ---------- ---------- ---------- ---------- AAHSNLRTGR DPAAAAAAAA RRVVVVAAAT ---------- ---------- ---------- CCCSLFYTGE LCLLLLAAAA GGVVVVHHHS CCNNYYMMMR VVVVDSLLLQ QDDDQQAAAN GGAPKAFLGK MEVVVVAAAA MMYYYYGGGL NNDDWWEEEH RRRRITILLG GDDDGGLLL- GGAPKAFLGK MDVVVVAAAA HHYYYYGGGL NNDDWWEEEH RRRRVTILLG GDDDGGLLL- GGAPTAFKGD LHVVVVDDDD LLYYYYGGGL TTQQLLRRRG EEEERTLLLG GTTTGGLLL- GGAPKAFQGN LHVVVVDDDD LLYYYYGGGL HHSSWWGGGG EEEEKTLLLG GKKKGGLLL- GGAPKAFKGD LHVVVVDDDD LLYYYYGGGL HHSSWWGGGG EEEEKLILLG GTTTGGLLL- GGAPKAFKGN LHVVVVDDDD LLYYYYGGGL HHSSWWGGGG EEEEKLILLG GTTTGGLLL- GGAPAAFTGD LHVVVVDDDD LLYYYYGGGL HHDDWWGGGG EEEEKTLLLG GTTTGGLLL- GGSPNHIKGN PHVVVVEEEE LLYYYYGGGV HHEEWWSSSK KKKKLTILLP PLLLGGAAA- GGSPNHIKGN PHVVVVEEEE LLYYYYGGGV HHEEWWTTTK KKKKLTILLP PRRRGGAAA- GGGPVTVRDE LCQQQQEEEE LLVVVVIIIK RR-------- ---------- ---------- GGAPKLFRGH PDCCCCDDDD QQYYYYGGGL NNRRWWEEER EEEEFTILLG GDDDGGLLL- GGAPNKWRGK NDLLLLDDDD QQYYYYGGGL NNKKWWTTTQ TTTTYTILLG GDDDGGIII- DDEPIMAESE SLKKKKTTTT LLKKKKPPPV AALL------ ---------- ---------- TTGWSMMFGM LDAAAAAAAA RRFFFFGGGI VVDDLLTTTR QQQQKVFVVP PPPP------ TTGWNMMFGM LDPPPPAAAA HHFFFFGGGV VVDDLLTTTK QQQQKVFVVP PPPP------ ---RPLLLLH HHDPTLLMGF INVVVVSSLL LKKDDDSSSI IWYDDGKKWW NVIIIAAELL ---RPLLLLH HHDPTLLMGF VNVVLLNNTT TKKDDDSSSI IWYDDGKKWW QVIIIAAQFF ---RPAAAAH HHDPVEEYGF VGVVVVDDTT TTTNNNEGSI IWRGGGKKFF HTIIIAAEAA ---RPAAAAH HHDPVEEYGF VGVVVVDDTT TTTNNNEASI IWRGGGKKFF HTIIIPPEAA ---RPAAAAH HHDPSDDYGF CGVVVVDDTT TTTNNNQGAI IFQDDGTTFF ETIIIPPVAA ---RPAAAAH HHDPTAAYGF VNVVIISSLL LKKDDDSSSI IWRKKDKKWW AVIIIAAEAA ---RPAAAAH HHDPTAAYGF MNVVVVSSLL LKKDDDSASI IWRNNGSSWW HVIIIAAEAA ---RPAAAAH HHDPATTYGF VGVVVVSSLL LEEDDDSASV VWRNNGSSWW GVIIIAAEAA --LRFLLLLH HHDPSTTQGF VGAALLSSSS SNNIIIRFYK KN-------- --SSSEEKII --LRFLLLLH HHDPDTTQGF VGAALLSSSS SNNIIIRFYK KN-------- --SSSEEKII --LRFLLLLH HHNPDAAQGF VGAALLSSSS STTIIIRFYK KN-------- --SSSEEKII --LRFLLLLH HHNPDAAQGF VGAALLSSSS STTIIIRFFK KN-------- --SSSQQKII --LRFLLLLH HHNPDAAQGF VGAALLSSSS STTIIIRFYK KN-------- --SSSEEKII --LRFLLLLH HHNPDAAQGF VGAALLSSSS STTIIIRFYK KN-------- --SSSEEKII --LRFLLLLH HHNPDAAQGF VGAALLSSSS STTIIIRFYK KN-------- --SSSEEKII --LRFLLLLH HHNPDAAQGF VGAALLSSSS STTIIIRFYK KN-------- --SSSEEKII --LRFLLLLH HHDPASSQGF VGAALLSSSS STTIIIRFYK KN-------- --SSSEEKII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPLRSIIIIH HHWKNNNQDY DVEEVVSSFF FSSGGGGGSD DP-------- --VVVKKRLL --LRFLLLLH HHDPDAAQGL VGAALLSSSS STTVVVRFYK KE-------- --AAAEEKII --LRFLLLLH HHNPDDDQGL VGAALLSSSS SSSIIIRFYK KE-------- --AAAEEKII --LRFLLLLH HHDPADDTGF VGAALLSSSS SNNMMMRFFK KT-------- --SSSEELII --LRFLLLLH HHDPADDTGF VGAALLTTSS SNNMMMRFFK KT-------- --NNNEEIII --LRFLLLLH HHDPSDDTGY VGAALLSSSS SNNMMMRFFK KN-------- --SSSEEIII --LRFLLLLH HHDPSDDTGF VGAALLSSSS SNNMMMRFFK KN-------- --SSSEEVII --LRFLLLLH HHDPSDDTGY VGAALLTTSS SNNMMMRFFK KT-------- --SSSEEVII --LRFLLLLH HHEPTEEHAF VGAALLGGSS SGGIIIRIHP PVS------- --AAATTLAA --LRFLLLLH HHEPTEEHAF VGAALLGGSS SAAIIIRIHP PDP------- --TTTSSLAA ---------- ---------- ---------- ---------- ---------- ---------- --LRFLLLLH HHNPRNNQGY VGAAFFXXXX XXXXXXXXX- ---------- ---------- --LRFLLLLH HHNPKAAEGF VGAALLNNAA AKKVVVHFKK KKD------- -FKKKVVIII ---------- ---------- ---------- ---------- ---------- ---------- --LRFPPPPW WWGSNNNYAF STAALLTTSS SQQLLLLIYE ED-------- ---------- --LRCAAAAW WWGEANNYCF TSAALLTTSS SQQLLLLIYE ED-------- ---------- EE--NLEILL LLVVPLLVVT TDIDDLLDDD DDKFFLYLLS GIEVRRQNFK PPTGGKKVGG EE--PLPVLL LLVVPLLVVT TDIDDLLDDD DDRFFLYVVS GLELRRQNHQ PPAGGRRVGG TTDDELPLLL LLVVPLLVVT TDIDDLLDDD DDRFFLYVVS GTEMRRQDHN PPAGGSSVGG PPEEKLPLLL LLVVPLLVVT TDIDDMMDDD DDRFFLYVVS GTEMRRQDRK PPAGGSSVGG DDDDDLDLLL LLCCPLLVVT TDIDDLLDDD DDKYYLYVVA GLEMHHQDMN PPTGGKKVGG DDDDQLPVLL LLVVPLLVVT TDIDDMMDDD DDRFFLYVVS GTDLLLQDFE PPTGGKKVGG SSDDQLPILL LLVVPLLVVT TDINNVVDDD DDRFFLYVVS GTELHHQDFN PPTGGKKVGG EEDDQLPLLL LLVVPLLVVT TDINNLLDDD DDRFFLYVVS GTELRRQDFN PPTGGSSVGG QQPPSKVKGG GGMMPLLIIT TDILLLLDDD DDRFFLYFFS LHDIRRQNQK PPTGGQQIGG QQPPSKVKGG GGMMPLLIIT TDILLLLDDD DDRFFLYFFS LHDIRRQNKK PPTGGQQIGG QQPPPKVKGG GGMMPLLIIT TDILLLLDDD DDRFFLYFFS LHDLRRQDQR PPTGGQQLGG QQPPPKVKGG GGMMPLLIIT TDILLLLDDD DDHFFLYFFS LHDIRRQDQR PPTGGQQLGG QQPPPKVKGG GGMMPLLIIT TDILLLLDDD DDRFFLYFFS LHDLRRQDQR PPTGGQQLGG QQPPPKVKGG GGMMPLLIIT TDILLLLDDD DDRFFLYFFS LHDLRRQDQR PP-------- QQPPPKVKGG GGMMPLLIIT T--------- ---------- ---------- ---------- QQPPPKVKGG GGMMPLLIIT TDILLLLDDD DDRFFLYFFS LHDLRRQDQR PPTGGQQLGG EEPPPKVKGG GGMMPLLIIT TDILLLLDDD DDRFFLYFFN LHDMRRQDKR PPVGGQQIGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDYYYAVAKK KKLLSEEFFP PPAWWFFSSS SDLLLIIFFL ---------- ---------- KKPPSKVEGG GGMMPLLIIT TDILLLLDDD DDRFFLYFFS LHDIRRQDRN PPVGGQQIGG QQPPSKVEGG GGMMPLLIIT TDILLLLDDD DDRFFLYFFS LHDIRRQDRN PPVGGQQIGG PPKKPLVQNN NNMMPLLIIT TDFLLLLDDD DDRFFLYFFV LHDIRRQDKN PPTGGQQLGG SSEEPLVQNN NNMMPLLIIT TDFLLLLDDD DDRFFLYFFV LHDIRRQDKN PPTGGQQVGG SSKKPLVENN NNMMPLLIIT TDFLLLLDDD DDRFFLYFFV LHDIRRQDKN PPTGGQQIGG SSKKPLVENN NNMMPLLIIT TDFLLLLDDD DDRFFIYFFV LHDIRRQDKN PPTGGQQIGG SSKKPLVRNN NNMMPLLIIT TDFVVLLDDD DDRYYLYLLV LHDIRRQDAK PPAGGQQVGG FFPPSKVSGG GGMMPLLIIT TDILLMMDDD DDRFFLYVVS LHDIRRQDLK VVNSSQQVGG TTPPSKVENN NNMMPLLIIT TDILLMMDDD DDRFFLYVVS LHDIRRQDKN PPNSSQQVGG ---------- ---------- ---------- ---------- ---------- ---------- ------GENN NNMMGMMMMT TDILLLLDDD DDRYYLYFFS RHDVRRQDAN PPTGGQQVGG PPKKLVTGSS SSMMGMMIIS SDIIILLDDD DDRFFLYVVN RHDVRRQDEN PPTGGQQLGG ---------- ---------- ---------- ---------- ---------- ---------- EEQQAKVADD DDDDILLPPV VDISSAADDD DDQTTLWIIN MDKTRRLDHK PPIYYEEKDR EEQQAKVADD DDKKVLLPPV VDISSNNDDD DDSRRLWVVN MDKTRRLDHH PPVYYEEKGA GIFHADDHP- ---------- -------GHH HHKKKLTPPP QLLIIIIRDD GRYYVTSLYT GLYHEPPHP- ---------- -------GAA AAEEEATPPP QIIVVVVRDD GRYYITSLYS GIARAPPHP- ---------- -------GRR RRTTTFAPPP QVVIIIIRDD GRYYWTSLYT GIARTPPHP- ---------- -------GKK KKAAAFAPPP QVVIIIIRDD GRYYWTSLYT GIVKTPPHP- ---------- -------GKK KKTTTFGPPP QVVIIIIRDD GRYYWTSLYT GIVSATTHPG ---------- ----AAANGG GGAAALNPPP QVVIIIIRDD GRYYFTSLYA GIVRAGGHP- ---------- ----AAASAA AAEEELNPPP QVVIIIIRDD GRYYFTSLYA GIVRAAAHP- ---------- -------SGG GGPPPLNPPP QVVVVVVRDD GRYYFSSLYS GSIVGGGSVQ VEE--LLTCP PELLVVVGKK KKRRRIPPPP QIILLLLLDD GRYYATSLYD GSIVGGGSVQ VEE--LLTCP PELLVVVGKK KKRRRVPPPP QIILLLLLDD GRYYVTSLYA GSIVGGGPVQ VEE--LLKSP PELLVVVGKK KKKKKVPPPP QIILLLLLDD GRYYVTSLYA GSIVDGGPVQ VDD--LLDSP PELLVVVGKK KKQQQVAPPP QIILLLLLDD GRYYVTSLYA GSIVGGGPVQ VEE--LLKSP PELLVVVGKK KKRRRVAPPP QIILLLLLDD GRYYITSLYA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSIVGGGPVQ VEE--LLKSP PELLVVVGKK KKRRRVAPPP QIILLLLLDD GRYYITSLYA GSIVGGGPVQ VEE--LLKSP PELLVVVGKK KKRRRVPPPP QIILLLLLDD GRYYVTSLYD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSILGGGPVT VEE--LLECP PDVVVVVGKK KKKKKVPPPP QIILLLLLDD GRYYVTSLYK GSIQGGGPVT VEE--LLECP PDVVVVVGKK KKIIIIPPPP QIILLLLLDD GRYYVTSLYI GLIQGSSPVA AGG--KKTWS SDPPIIIGQQ QQKKKLRPPP QIILLLLLDD GRYYVTSLFA GLIQGSSPVV AKK--EETWS SDPPIIIGKK KKKKKLRPPP QIILLLLLDD GRYYVTSLFA GLLQGSSPVK AGG--NNSFF FDPPIIIGKK KKSSSLRPPP QIILLLLLDD GRYYATSLFA GLLQGSSPVK AGG--NNTFF FEPPIIIGKK KKSSSLRPPP QIILLLLLDD GRYYATSLFA GLLQGSSEVV YTT--KKEEY YSPPVVVGHH HHRRRLRPPP QIILLLLLDD GRYYVTSLFR GSVHESSNVK VEE------I IELLVVVGRR RRKKKIEPPP QLLLLLLLDD GRYYVTSLYK GSIHETTTVK VEE--DD--I IPLLVVVGRR RRQQQIEPPP QLLLLLLLDD GRYYVSSLYK ---------- ---------- ---------- -------PPP AIILLLLVDD GRYYVTSFYT GAIQDAAPRR VNN--LLKEP PEVVLLLGRR RRRRRLLPPP QLLLLLLLDD GRYYVSSLFP GAICDLLPNV IKKEELLKEP PPRRVVVGRR RRRRRLEPPP QLLLLLLLDD GRYYVSSLYP ---------- ---------- ---------- ---------- ---------- ---------- RQVN------ ---------- ---------- ---------- -VVQQQQWDD GRYYFSSLLN AQVN------ ---------- ---------- ---------- -VVSSSSWDD GRYYYTSLLN TWNYYGKMMV LAN-----PS GGLEEDFFFV VDGGEE---- AARSHHQLSG GASSYYCYPP SWNYYGRMMA VVN-----PE GGLEEEFFFV VDGGRR---- AARAHHQLWG GASTFFCYPP TWDYYGPQQV AAG-----PD GGLTTAYYYV VEPPDDGG-- YYRAHHQLEG GCSTFFCYPP TWDYYGPEEV AVG-----GN GGLEEDYYYV VSPPDDGG-- YYRAHHQLEG GCSTFFCYPP TWEYYDGMMV AVG-----EN GGLTTDFFFV VDPPAAGG-- YYRSHHQLEG GCSTFFCYPP AVPYYGDMMV LAG-----PN GGIEEDFFFL LEPPKKGG-- HHRPHHQLQG GCSSYYCYPP AWEYYGKMMV VVN-----PD GGMQQDFFFV VDGGEE---- QQRVHHQLQG GASSYYCFPP SWEYYGRIIA AAD-----PG GGLSSDFFFT TEGGDDGG-- LLRPHHQLEG GSSSYYCYPP DWKYYDIGGS MQVDDVDTVN GGLKKNFFFV VDGGKKEELP AALAHHEYPG GCSSWWI--- AWKYYNIGGS MQIDDVDTAN GGLKKNFFFV VDGGKKEELP AALAHHEYPG GCSSWWI--- AWKYYDIGGS MQIDDVDTVK GGLKKNFFFV VDGGKKEELP AALAHHEYPG GCSSWWL--- AWKYYDIGGS MQIDDVDTVK GGLTTNFFFV VDGGKKEELP AALAHHEYPG GCSSWWL--- AWKYYDIGGS MQVDDVDTVK GGLKKNFFFV VDGGKKEELP AALAHHEYPG GCSSWWI--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AWKYYDIGGS MQVDDVDTVK GGLKKNFFFV VDGGKKEELP AALAHHEYPG GCSSWWI--- DWKYYDIGGS MQIDDVDTVK GGLKKNFFFV VDGGKKEELP AALAHHEYPG GCTSWWL--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KWKYYDIGGS MQIDDVDTEK GGLKKNFFFV VDGGKKEEGP VVLAHHEYPG GCSSWWV--- IWKYYDLGGA MQIDDVDTKK GGLKKNFFFV VDGGKKEEDP VVLAHHEYPG GCTSWWI--- AWKYYGVGGS IQIDDVDTEK GGLKKNFFFV VDGGAAEEDP AALAHHEYPG GCTSWWI--- AWKYYKVGGS IQIDDVDTEN GGLKKNFFFV VDGGAAEEDP SSLAHHEYPG GCTSWWI--- AWRYYEMGGS IQIDDVDTEK GGLSSNFFFV VDGGDDEEEP AALAHHEYPG GCTSWWI--- AWVYYEMGGS IQIDDGDTEK GGLTTNFFFV VDGGDDEEDP SSLAHHEYPG GCTSWWI--- RWEYYDVGGS MQIDDVDTEK GGLSSNFFFV VDGGAAEEEP SSLAHHEYPG GCTSWWI--- KWDYYEVGGA MQVNNIDPES GKMEENFFFI IDGGKKIIGP YYLAHHEYPG GCTSWWI--- KWDYYEVGGA MQIDDVDPIT GHMVVNFFFI IDGGKKVVGP YYLAHHEYPG GCTSWWI--- TWKYYNVGGS MQIDDVDTEK GGLTTNFFFV VDGGKKEENP CCLAHHDFPC CSTSLLA--- PWKYYEVGGG IQLDDIDVEN GGMKKNFFFV VDGGGGEEYP GGLPHHE--- ---------- PWKYYKVGGG ILIDDVDTVN GGISSNFFFV VDAANNEEYP SSLPHHEYPG GCTSWWLANN ---------- ---------- ---------- ---------- ---------- ---------- NW-----GGK DQYLLKAYNW DGKEEVFFFV VDYYEELLL- --RAHHIFGS SLYS------ NW-----GGK DQFLLKLYYW DGKEEKFFFI IDYYAAEEL- --RPHHQFGA ALYAAAGDGG P------ P------ PSSSVR- PSSSV-- PSSSV-- P------ P------ PSSS--- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- NDDDA-- ------- ------- GNNNRVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158SAKAAAKKPS ETPCCCCRTA AVPGGTAALA AGGGAQSLPT TLLLLTGGSS PPPVRKKYQA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -------MAR gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAAAAWTTFF SSSSSSAAII QVVVLSSSRS SKGGKKSSVV VPGGLLVISA AVVAAKVVVP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRSSSAPPTT LLPPPPPPLL NNNNRPTTHP PLAAAAPPHH HPRRVVPTLV VRRPPYTIIN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMAI VPFKRRDFFF YPSPPAAAPP ---------- ---------- ---------- ---------M AKLKPPDFFF YPTPPAAAPP ---------- ---------- ---------- ---------- MSMRPPDFFF HASPPAAAPP ---------- ---------- ---------- ---------- MTMRPPDFFF HASPPAAAPP ---------- ---------- ---------- ---------- MTLRPPDFFF YPSAAAAGPP ---------- ---------- ---------- ---------M ATWKPPDFFF YPSPPAAAPP ---------- ---------- ---------- ---------M VTWRPPDFFF YPSPPAAAPP ---------- ---------- ---------- ---------M ASWRPPDFFF YPSPPAAAPP ---------- ---------- ---------- ---AAATTKC TK--CCGYYY PTPLLMMGPP ---------- ---------- ---------- ---------- ---------- -------GPP PSQQWWPPPP PPGGAAVLAA PAAARRGGGP GG-SSSTTQC GK--CCGYYY PSPLLMMGPP ---------- ---------- ---------- ---------- ---------- -----MMGPP ---------- ---------- ---------- ---AAATTKC GN--CCGYYY STPLLMMGPP ------AAAE EEGGAFTLSS VAAAQQPPPP IIAAAATTKC GN--CCGYYY STPLLMMGPP ---------- ---------- ---------- ---AAATTKC GN--CCGYYY STPLLMMG-- ---------- ---------- ---------- ---AAATTKC GN--CCGYYY STPLLMMGPP -----GGGGK KKGGHTAQWW FLLLSSGGGW QQEAAATTKC GD--CCGYYY PTPQQMMGPP ----LNQQQG GGFFDQTNEE LHHHTTYYYL VVFPPPTTKC GN--CCGYYY STPLLMMGPP ---------- ---------- ---------- ---AAATTKC GN--CCGYYY STPLLMMGPP NVPPCHRRRH HHLLQHIMGG AAAAAAVVVA AAAGGGKKTC CHTAKKGYYY ATPLLMMGPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMMAAKC GS--CCGYYY KSPLLMMGPP ---------- -------MTT VLLLDDHHHV NNESSS--VN GCCKSSGYYY ASPIIMMGPP ---------- -------MTT VLLLQQHHHV SSENNNNNQQ GCCKSSGYYY ASPLLMMGPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R MLQVGGGYYY ATPLLMMGPP ---------- ---------- ---------A AAAGGGAAAC CGGATTGYYY ATPLLMMGPP ---------- ---------- ---------M SSPGGGLLKC HG----GYYY ASPAAIIGPP ---------- ---------- ---------M PP-PPPLLKC HG----GYYY ASPAAIIGPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMSE SKCKCCGYYY ATPLLVVGPP ---------- ---------- ---------- ---------- ---------- -----MMGPP ---------- ---------- ---------- ---------- ------MLLL IT---LLLDD ------KKKR RRGG------ ------AAAA GG-AAAMMGL PFRAFFATTT CQSPPPPTGG ------KKKR RRSSGPSMFF ALLLRRAAAS GGLAAALLAA PAGVRRATTT CASPPKKTGG EDLAYYYYYY TTTTGGNAAA VVDNNPPKSE ETSSIVHKKV LPINDEEEHH HFGWWAAALL EDIAYYYYYY VTTTGGNPAA VVDDDPPKSP PTGGVIYKKL LPIGDEEEHH HFGWWAAAYY EEFAYYSSSS PFFFSS-PAA IIDKKPPGSS STGGIVHTTV MPTGDEEEHH HFGWWAASLL ENFAYYSSSS PFFFSS-PAA IIDKKPPGSP PTGGIVHTTV MPKGDEEEHH HFGWWAAALL EKLAFFSSSS PAAASS-PAA VVDDDPPTSE EKGGIVHQQL MPKGDEEEHH HFGWWAAALL ETIAYYDDDD PRRRKK-PAA VVDDDPPASP PRAAIVGQQV MPAGDEEEHH HFGWWAACLL EKLAYYNNNN PAAANN-PCC VVDDDSSQSS STGGVVGVVT MPTGGEEEHH HFGWWAAMLL ERLGYYDDDD PRRREE-PGG LLDDDPPDSG GTAAIVGRRV MPAADEEEHH HFGWWAAALL EEIVYYYYYY RTTTGGEPAA VVDDDPPKSP PQSSVIHRRL MPLKDEEEHH HSGWWTTC-- EEIVYYYYYY RTTTGGEPAA VVDDDPPKSP PHSSVIHRRL MPLKDEEEHH HSGWWTTC-- EEIVYYYYYY GTTTGGEPAA VVDDDPPKSP PQCCVIHRRL MPLRDEEEHH HSGWWAAC-- EEIIYYYYYY RTTTGGEPAA VVDDDPPKSP PQCCVIHRRL MPLKDEEEHH HSGWWTTC-- EEIVYYYYYY RTTTGGEPAA VVDDDPPKSP PQCCVIHRRL MPLKDEEEHH HSGWWTTC-- EEIVYYYYYY RTTTGGEPAA VVDDDPPKSP PQCCVIE--- ---------- ---------- ---------- ------EPAA VVDDDPPKSP PQCCVIHRRL MPLKDEEEHH HSGWWTTC-- EEIVYYYYYY RTTTGGEPAA VVDDDPPKSP PQCCVIHRRL MPLKDEEEHH HSGWWTTC-- EEIVYYYYYY RTTTGGEPAA VVDDDPPKSP PQSSVIHRRL MPLKDEEEHH HSGWWTTC-- EEIVYYYYYY RTTTGGEPAA VVDDDPPKSP PQCCVIHRRL MPLKDEEEHH HSGWWTTC-- EEIVYYYYYY RTTTGGEPAA VVDDDPPKSP PQCCVIHRRL MPLKDEEEHH HSGWWTTC-- EKLVYYYYYY NTTTGGNLAA VVDDDPPSSP PTSSVIHRRL VIIGDKKKHH HSGWWSSC-- ---------- ---------- ---------- ---------- MPTNDEEEHH HSGWWTTC-- EEIVYYYYYY RTTTGGNPAA VVDDDPPKSP PSSSVIHRRL MPVNDEEEHH HSGWWTTC-- ESLIYYYYYY ATTTGGEPAA VVDDDPPSSP PTSSVIHRRL VPVGDEEEHH HTGWWSSC-- ETLIYYYYYY ATTTGGEPAA VVDDDPPNSP PTSSVIHRRL VPVGDEEEHH HTGWWSSC-- ---------- ---------- ---------- ---------- MPVGDEEEHH HSGWWSSC-- EKLIYYYYYY TTTTGGDPAA VVDDDPPSSP PSSSVIHRRL MPVGDEEEHH HSGWWSSC-- EKLLYYYYYY NTTTGGNPGG VVDDDPPNSP PTSSVIHRRL VTVGDEEEHH HSGWWAAC-- EEVLFF---- -NNNAADPFF VVDNNPPESD DTCCVISRRV VPIGDEEEHH HTGWWAAC-- EEVLFF---- -HHHAADPFF VVNNNPPESE ETCCIISRRV VPIGDEEEHH HTGWWAAC-- ---------- ---------- ---------- ---------- ---------- ---------- EKLLYYQQQQ PLLLDDEGAA VVDDDPPASP PTCCVIHRRT TNKHNEEEHH HSGWWTTCHH EKLLYYQQQQ PLLLDDPGSS VVDDDPPESP PTCCIVHRRT TNKGDEEEHH HSGWWAACYY RFLYFFHHHH GIIIRRYIKK PPRVVGGQVF FLGGVLKDDG VKLEDKKKLL DSQPPPPK-- EEFVYYGGGG VGGGMMDQVV IIDRRPPGSA ATGGVINSSV VG-RNEEEHH HGGFFAA--- EDYVYYGGGG AGGGVVDQVV VVDNNPPKSP PQGGVVNTTL VG-RNEEEHH HSDFFDD--- CCCPNN-KKP PIERFLLVVV PGRSSSSIID DTKKKKPNPE EIIIVVIIEE PPEEVVSGSS CCCPNN-KKP PLERYLLVVV PARSSSSIID DTKKKKPDKR RAAAIIVVEE PPEEAATGTT SSSPLLGHHA ALERFLLIII PGRSSSSIVD DTKKKKPHPQ QHHHIIIIEE PPDDIITGSS SSSPLLGHHA AIERYLLIII PGRSSSSIID DTKKKKPDPK KHHHIIIIEE PPEEVVTGSS SSSPLLGHHA ALERYLLIII PGRSSSSIID DVKKKK-EPK KHHHIIIIEE PPEEVVTGSS CCCPNNPHHP PMERYLLVVV PGRSSSSIID DTKKKKPDPK KAAAVVIIEE PPEELLTGSS CCCPNNPHHP PVERYLLVVV PDRSSSSIID DTKKKKPDPQ QVVVVVIIDD PPNNLLTGAA CCCPYYPHHP PVERYLLVVV PGRSSSSIID DTKKKKPDPE EVVVVVIIEE PPEELLTGSS ------GDDS SKSNKLLLLL PGMSSSSIVD DVGGGGSEPA AHHHVVIIEE AASSIICNSS ------GDDS SKSDKLLLLL PSISSSSIVD DVGGGGSEPA AHHHVVIIEE PPNNIICNGG ------GDDS SKSTKLLLLL PCMSSSSIVD DVGGGGSDPA AHHHVVIIEE AAEEIICGGG ------GDDI IKATKLLLLL PAISSSSIVD DVGGGGTEPA AHHHVVIIEE PPKKIICNGG ------GDDS SKSTKLLLLL PSISSSSIVD DVGGGGSEPA AHHHVVIIEE PPEEIICEAA ---------- ---------- ---------- ---------- ---------- PPKKIICEAA ------GDDS SKSTKLLLLL PSISSSSIVD DVGGGGSEPA AHHHVVIIEE PPKKIICEAA ------GDDS SKSTKLLLLL PSISSSSIVD DVGGGGSEPA AHHHVVIIEE PPKKIICEAA ------GDDS SKSNKLLLLL PSISSSSIVD DVGGGGTEPA AHHHVVIIEE AAKKIICGGG ------GDDS SKSTKLLLLL PS-------- ---------- ---------- ---------- ------GDDS SKSTKLLLLL PSISSSSIVD DVGGGGSEPA AHHHVVIIEE PPKKIICEAA ------GDDP PAKRFLLLLL PSLSGGGVVD DTAAAATDPT THHHVVVVEE SSEEIIIGGG ------GDDA AKVNKLLLLL PCISSSSIVD DVGGGGTDPA AHHHTTVVEE PPYYVVCGAA ------GDDS SKVNKLLLLL PCISSSSIVD DVGGGGSDPA AHHHTTVVEE PPYYVVCGAA ------GDDP PAERFLLAAA PSVSGGGIVD DTKKKKTNPS SHHHVVVVDD PPAAIITGAA ------GDDP PAQRFLLVVV PGVSGGGVVD DTKKKKTNPA AHHHVVVVEE PPEEIITGAA ------GDDA AADRYLLLLL PSISGGGIAD DTKKKKENPA AYYYYYVVDD PPKKIITGAA ------GDDA AVDRYLLLLL PSISGGGIAD DTKKKKENPA AYYYYYVVDD PPKKIITGAA ------GDDP PASRFLLLLL PSLSGGGVVD DTLLLLKDPA AHHHVVVVEE AAEEIITGGG ------DKKP PEKSHLLVVV PCNSDDDIIN NVEEEENE-K KEEETTIIEE PPSSLLN-SS ------DKKP PEKSHLLVVV PCNSDDDIVN NVEEEENE-E EQQQTTIIEE PPSSLLN-SS ---------- -----MMPPP RKSSGGGEKF FVGGGGG--- ---------- ---------- FFFP--GKKE EPTDRLLLLL PCNSDDDIVD DTGGGGTDPA AAAAVVIIEE GG--VVADTT YYYDEESKKT TPKDRLLLLL PSNSDDDIID DVVVVVTDPK KVVVTTIIDD GG--VVHNTT ------GKKR RQGPQMMQQQ LSDGKKKLVT TSLLLLYSAD DYYY------ ----LLLVAA ---------- --DRFFFTTT GGDTNNNIID DVHHHHSDPN NHHHTTIIDD TT--VVGGVV ---------- --DRYLLAAA GGDTSSSIVD DVHHHHSDPR RSSSTTIITT DD--VVGGVV HCGYSSGNE- -EEGEEGGPG GGLHEPPLLK WWDGGGGQQQ Y--------A DFFWWWLPNV HCGYSSGGP- -DDGEEGGPG GGFHEPPIIR WWYGGGGQQQ Y--------A DFFWWWLPSV HCGYSSGGAG KDDGDDGGAG GGFCDVVLLR WWDGGGGQQQ D--------H DFFWWWLPRY HCGYSSGGGG KDDGNNGGPG GGFCEVVLLR WWDGGGGQQQ T--------H DFFWWWLPRY HCGYSSGGGG EDDGDDGGPG GGFCEIILLR YYDGGGGQQQ T--------H DFFWWWLPRY HCGYTTGNA- -EEGKKGGPG GGAAEPPLLR WWEGGGGQQQ Y--------A DGGWWWLGYT HCGYSSGSP- -EEGEEGGPG GGFHEVVLLR WWDGGGGQQQ Y--------H DFFWWWLGYT HCGYSSGSP- -EEGDDGGPG GGFHDPPLLR WWEGGGGQQQ Q--------A DFFWWWLGYT HCLVVVLGD- -LLQNNGGKS SSVGEVVKKT WWPGGGGSSS P--------G DFFYYYPRHV HCLVIILGD- -PPQNNGGKG GGVGEVVKKT WWPGGGGAAA P--------G DFFYYYPRHI HCLVIILGD- -SSKNNGGKG GGVGEVVKKT WWPGGGGAAA P--------G DFFYYYPRHV HCLVVVLGD- -PPENNGGKG GGVGEVVKKT WWPGGGGAAA P--------G DFFYYYPRHV HCLVIILGD- -VVKNNGGKG GGVGEVVKKT WWPGGGGAAA P--------G DFFYYYPRHV HCLVIILGD- -VVKNNGGKG GGVGEVVKKT WWPGGGGAAA P--------G DFFYYYPRHV HCLVIILGD- -VVKNNGGKG GGVGEVVKKT WWPGGGGAAA P--------G DFFYYYPRHV HCLVIILGD- -VVKNNGGKG GGVGEVVKKT WWPGGGGAAA P--------G DFFYYYPRHV HCLVIILGD- -PPKNNGGKG GGVGEVVKKT WWPGGGGAAA P--------G DFFYYYPRHV ---------- ---------- ---------- ---------- ---------- ---------- HCLVIILGD- -VVKNNGGKG GGLPECCSS- ---------- ---------- ---------- HCLIIILGD- -KKENNAAAN NNFDNVVKKR GGRFFFFIII S--------E THHYYYNAWL HCLIIIIGD- -PPYNNGGKG GGVGEVVKKN WWEEEEEAAA P--------G DFFYYYPRHV HCLIIILGD- -PPCNNGGKG GGVGEVVKKN WWEEEEEAAA Q--------G DFFYYYPRHV HCLLIILGD- -KKDNNAAEN NNFDNVVKKR WWPHHHHPPP L--------G DFFYYYPRHT HCLIIIIGD- -KKDNNAAEN NNFDNVVKKR WWPHHHHPPP L--------G DFFYYYPRHT HCLIVVLGD- -EEENNAAKN NNFDNIIKKR WWPHHHHPPP L--------G DFFYYYPRHT HCRIVVLGD- -EEENNAAKN NNLDNIIKKR WWPIIIIPPP L--------G HFFYYYPRHT HCLIIILGD- -KKENNAAAN NNFDNVVKKR WWPHHHHPPP L--------G DYYYYYPRHT HCLIIILGE- -AANTTPPSN NNLGEPPKKT WWDKKKKVVV P--------N DFFYYYPRRV HCLIIILGE- -AADSSPPSN NNLGEPPKKT WWDKKKKVVV P--------N DFFYYYPRRI ---------- ---------- ---------- ---------- ---------- ---------- HCLIIIMGD- -AAENNAAK- --FDELLVVT WWGRRRRAAA L--------G DYYYYYPHFV HCLIIIMGD- -AAEYYAAK- --FDNCCIIT WWGKKKKAAA L--------G DFFYYYPYFV DYQLQQVNE- -SSLVVPPVN NNIKGLLSSK GGSFFFFEEE I--------Q SNNNNNG-RK FALMTTSND- -DDDGGGGRA AAVDYVVAAY WWTDDDDMMM QGAAAGADGG DIIAAAIRKV YALLTTSNN- -KKDGGGGRA AAVNYVVAAH WWTGGGGLLL RGKKKGADGD DVVAAAPRKL LVSSP--TIE GG--KKKLEH YYYYNRIHHL RKRKISSLLT LLEM------ --ELRRPHPT MITTP--CFE GG--SSSLEC YYYYNKLHHL AKRRLAAIID LLEM------ --EVRRPHPT MVSSP--QFE GG--VVVPED YYYYHRLHHL RARRVTTIID LLQM------ --EVRRPHPV MVTTP--QFE GG--VVVPED YYYYHRLHHL RARRVTTIID LLNM------ --EVRRPHPV MVSSP--QFE GG--VVVPED YYYYHKIHHL RDRKVTTIID LLNM------ --EIRRPHPS LVTTP--MVE GG--VVVPDI YYYYRRLHHL TRRRLEEIID FFEL------ --ELRRPHPT LLTTP--MVE GG--LLLGDE YYYYHRLHHL YRRRLTTLLD LLEM------ --ELRRPHPT MVTTP--MIE GG--DDDPQI YYYYRRLHHL RRRRLAALLD VVEM------ --ELRRPHPA MVSSP--VFK GGFFPPPAHV YYYYSRIFFW QRHEITTLLQ MM-L-----L LLEIRRFHPS MVSSP--VFK GGFFPPPAHV YYYYSHIHHW QRHEITTLLQ MM-L-----L LLEIRRFHPD MISSP--VFR GGFFPPPADV YYYYSHLHHW QRHEITTLLT LL-L-----L LLEIRRFHPD MISSP--VLR GGFFPPPADV YYYYSHLYYW QRREVTTLLP LL-L-----L LLEIRRFHPD MISSP--VLR GGFFPPPADV YYYYSHLYYW QHHEVTTLLS LL-L-----L LLEIRRFHPD MISSP--VLR GGFFPPPADV YYYYSHLYYW QRHEVTTLLS LL-L-----L LLEIRRFHPD MISSP--VLR GGFFPPPADV YYYYSHLYYW QRHEVTTLLS LL-L-----L LLEIRRFHPD MISSP--VLR GGFFPPPADV YYYYSHLYYW QRHEVTTLLS LL-L-----L LLEIRRFHPD MISSP--VVQ GGFFPPPADV YYYYKHLHHW QRHEVTTLLL MM-H-----L LLEIRRFHPA ---------- ---------- ---------- ---------- ---------- ---------- ----S--LRL GGSSDDDYPA VVVVGIT--- ---------- ---------- ---------- FWSSS--FYT GGAALLLMCL VVVVVISCCY IMRVDSSLLP LL-ANNNIIL LLCLRRSHKN MISSP--AFA GGFFMMMEEV YYYYHSLNNW TEHRITTIID LL-L-----L LLEIRRFHPD MISSP--AFA GGFFMMMEDV YYYYHSLNNW TEHRVTTIID LL-L-----L LLEIRRFHPD MISSP--AFT GGFFLLLQHV YYYYRHLTTL ARGERTTLLD LL-L-----L LLEIRRFHPA MISSP--AFL GGFFLLLQHV YYYYRHLHHW PGGEKTTLLD LL-L-----L LLEIRRFHPA MISSP--AFS GGFFLLLQHV YYYYSHLHHW PGGEKLLIID LL-L-----L LLEIRRFHPS MISSP--AFS GGFFLLLQHV YYYYSHLHHW PGGEKLLIID LL-L-----L LLEIRRFHPS MISSP--AFR GGFFLLLQHV YYYYRHLHHW PGGEKTTLLD LL-L-----L LLEVRRFHPS MISSP--HIK GGFFPPPAHV YYYYNSVHHW DSKKLTTIID LLPA-----L LLEVRRFHPT MISSP--HIK GGFFPPPAHV YYYYNSVHHW DTKKLTTIID LLPA-----L LLEVRRFHPT --SSP--TVC DDEELLLKCQ VVVVKCKRR- ---------- ---------- ---------- MVAAP--LFR GGYYPPPTDC YYYYCRLNNW QEREFTTIID LL-L-----L LLEIRRFHPR MVSSP--KWR GGWWNNNVDL YYYYCRLNNW STQTYTTIID LL-I-----L LLEIRRFHPK SESSP--MAF SSSSSSSFLK KKKKQHVAA- ---------- ---------- ---------- MLTTWNYMMD GGQQLLLQDA FFFFNTIVVL HTRQKVVFFN VVA------L LLEIRRFWSN LVTTWNYMMD GGKKLLLADP FFFFNTVVVL HTKQKVVFFD VVA------L LLEIRRCWEA MNMMVVVVVV LDSSSFYY-E EKWWAAEEVV IIAAAEGGNN ELPPFKKAPP LLVVTIIDDD MNVVVVVLLL TDSSSFYY-E EKWWAAEEVV IIAAAEGGPP PLDDFKKMPP LLVVTIIDDD YGVVVVVVVV TNEGSWRR-E EKFFVVKKTT AAAAATAAEE PLGGFGGAPP LLVVTIIDDD YGVVVVVVVV TNEASWRR-E EKFFAAEETT AAPPPPKKKK PLGGFGGAPP LLVVTIIDDD YGVVVVVVVV TNQGAWQQKD DTFFAAKKTT IIPPPDAADD DLGGFGGAPP LLVVTIIDDD YNCCVVVIII LDSSSYRR-D DKWWVVRRVV IIAAADPPQQ PLGGFKKAPP LLVVTIIDDD YNCCVVVVVV LDSASYRR-D DSWWLLKKVV IIAAASEEQQ PLPPFKKAPP LLVVTIINNN YGVVVVVVVV LDSASHRR-Q QSWWIIRRVV IIAAAEPPQQ PLDDFGGAPP LLVVTIINNN QGCCAAALLL SIRFYG---- ---------- TTEEEQVVSS VGMMLPPEPG LLIITIILLL QGCCAAALLL SIRFYG---- ---------- TTEEEQVVSS VGMMLPPEPG LLIITIILLL QGCCAAALLL SIRFYG---- ---------- TTEEEQVVPP VGMMLPPEPG LLIITIILLL QGCCAAALLL SIRFFG---- ---------- TTQQQQVVPP VGMMLPPEPG LLIITIILLL QGCCAAALLL SIRFYG---- ---------- TTEEEQVVPP VGLLLPPEPG LLIITIILLL QGCCAAALLL SIRFYG---- ---------- TTEEEQVVPP VGLLLPPEPG LLIITIILLL QGCCAAALLL SIRFYG---- ---------- TTEEEQVVPP VGLLLPPEPG LLIIT----- QGCCAAALLL SIRFYG---- ---------- TTEEEQVVPP VGLLLPPEPG LLIITIILLL QGCCAAALLL SIRFYG---- ---------- TTEEEEVVPP VGMMLPPEPG LLIITIILLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QVVVEEEVVV FGGGSY---- ---------- AAKKKDLLYY VKGGVVVSSN EEFFPAAWWW QGCCAAALLL SVRFYG---- ---------- KKEEEKVVSS VGAALPPEPG LLIITIILLL QGCCAAALLL SIRFYG---- ---------- KKEEEQVVSS VGPPMPPEPG LLIITIILLL TGSSAAALLL SMRFFG---- ---------- SSEEEPVVPP VNIILPPEPG LLIITFFLLL TGSSAAALLL SMRFFG---- ---------- SSEEESVVPP VNFFLPPEPG LLIITFFLLL TGSSAAALLL SMRFFD---- ---------- TTEEESVVPP VNIILPPEPG LLIITFFLLL TGSSAAALLL SMRFFE---- ---------- TTEEESVVPP VNIILPPEPG LLIITFFLLL TGCCAAALLL SMRFFG---- ---------- SSEEESIIPP VNIILPPEPG LLIITFFVVV HGCCAAALLL SIRIHNSS-- ---------- TTTTTFIISS VGAALPPEPA LLIITIILLL HGCCAAALLL SIRIHNPP-- ---------- VVSSSTIISS VNAALPPDPA LLIITIILLL ---------- ---------- ---------- ---------- ---------- ---------- QGCCAAAFFF XXXXX----- ---------- ---------- GNEEIEEMGG MMMMTIILLL EGCCAAALLL AVHFKSDD-- --------FF EEVVVPGGLL TSVVAEEDGG MMIISIIIII ---------- ---------- ---------- ---------- ---------- ---------- YTTTAAALLL SLLIYG---- ---------- -----EWWAA VDGGNPPAIP LLPPVIISSS YSTTAAALLL SLLIYG---- ---------- -----EWWAA VDGGEPPAVP LLPPVIISSS ILLLDFLLYY LGGIIEVVVV QIISSPPFFF KPPPVLTTTK VVLLLGGGGG FFRRAAHP-- ILLLDFLLYY VGGLLELLLL QIITTPPHHH QPPPRLAAAR VVIIIGGGGG YYRREEHP-- LLLLDFLLYY VGGTTEMMMM QVVSSPPHHH NPPPVLAAAS VVIIIGGGGG AARRAAHP-- LMMMDFLLYY VGGTTEMMMM QVVSSPPRRR KPPPKLAAAS VVIIIGGGGG AARRTTHP-- LLLLDYLLYY VGGLLEMMMM QVVSSPPMMM NPPPVLTTTK VVIIIGGGGG VVKKTTHP-- LMMMDFLLYY VGGTTDLLLL QVVSSPPFFF EPPPKLTTTK VVIIIGGGGG VVRRAAHP-- LVVVDFLLYY VGGTTELLLL QVVSSPPFFF NPPPRLTTTK VVIIIGGGGG VVRRAAHP-- LLLLDFLLYY VGGTTELLLL QVVSSPPFFF NPPPRHTTTS VVLLLGGGGG VVKKAAHP-- LLLLDFLLYY FLLHHDIIII QIISSPPQQQ KPPPRLTTTQ IILLLGGGGG IIRRGGSVVV LLLLDFLLYY FLLHHDIIII QIISSPPKKK KPPPRLTTTQ IILLLGGGGG IIKKGGSVVV LLLLDFLLYY FLLHHDLLLL QIISSPPQQQ RPPPRLTTTQ LLLLLGGGGG IIKKGGPVVV LLLLDFLLYY FLLHHDIIII QVVSSPPQQQ RPPPRLTTTQ LLLLLGGGGG IIKKDDPVVV LLLLDFLLYY FLLHHDLLLL QIISSPPQQQ RPPPRLTTTQ LLLLLGGGGG IIKKGGPVVV LLLLDFLLYY FLLHHDLLLL QIISSPPQQQ RPPPRL---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLLLDFLLYY FLLHHDLLLL QIISSPPQQQ RPPPRLTTTQ LLLLLGGGGG IIKKGGPVVV LLLLDFLLYY FLLHHDMMMM QIISSPPKKK RPPPRLVVVQ IILLLGGGGG IIKKGGPVVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IFFFSLIIII F--------- ---------- ---------- ---------- ---------- ILLLDFLLYY FLLHHDIIII QIITTPPRRR NPPPKLVVVQ IILLLGGGGG IIRRGGPVVV ILLLDFLLYY FLLHHDIIII QIITTTTRRR NPPPKLVVVQ IILLLGGGGG IIRRGGPVVV ILLLDFLLYY FLLHHDIIII QIIEELLKKK NPPPVLTTTQ LLVVVGGGGG IIKKGGPVAA ILLLDFLLYY FLLHHDIIII QIIEEVVKKK NPPPKLTTTQ VVAAAGGGGG IIKKGGPVAA ILLLDFLLYY FLLHHDIIII QIIEEPPKKK NPPPVLTTTQ IIVVVGGGGG LLKKGGPVAA ILLLDFIIYY FLLHHDIIII QIIEEPPKKK NPPPVLTTTQ IIVVVGGGGG LLKKGGPVAA ILLLDYLLYY LLLHHDIIII QIIEEPPAAA KPPPVLAAAQ VVAAAGGGGG LLKKGGEVYY IMMMDFLLYY VLLHHDIIII QIISSPPLLL KVVVKLNNNQ VVIIIGGGGG VVTTEENVVV IMMMDFLLYY VLLHHDIIII QIISSPPKKK NPPPKLNNNQ VVIIIGGGGG IISSEETVVV ---------- ---------- ---------- ---------- ---------- ---------- ILLLDYLLYY FRRHHDVVVV QIISSRRAAA NPPPRLTTTQ VVLLLGGGGG IIRRDDPRVV ILLLDFLLYY VRRHHDVVVV QIITTPPEEE NPPPKLTTTQ LLLLLGGGGG IISSDDPNII ---------- ---------- ---------- ---------- ---------- ---------- IAAADTLLWW IMMDDKTTTT LIISSPPHHH KPPPFQIIIE KKIIIDDRRR VV-------- INNNDRLLWW VMMDDKTTTT LIISSPPHHH HPPPRQVVVE KKIIIGGAAA VV-------- ---------- ---------- --AGTAMMLL EIISSSSRRV TSLLLYYSSW WWWWDDDDFY ---------- ---------- --SGTAMMII SVVSSSSRRV TSLLLYYSSW WWWWNNNNFY ---------- ---------- --NGAGMMVV EIISSSSRRV TSLLLYYSSW WWWWDDDDFY ---------- ---------- --NGAGMMVV EIISSSSRRV TSLLLYYSSW WWWWDDDDFY ---------- ---------- --NGGGMMVV EIISSSSRKV TSLLLYYSSW WWWWDDDDFY ---------- ---------- -AKNNGMMVV EIISSSSRRV TSLLLYYGGV VVVVDDDDFY ---------- ---------- -ATSNGMMVV EIISSSSRRV TSLLLYYRRW WWWWDDDDFY ---------- ---------- --ASNGMMVV EVVSSSSRRV SSLLLYYAAW WWWWDDDDFY EEE-DDDQEE TCCQQPEPPP LVKGPGMMII QLLSSSSLKL TSLLLYYSSW WWWWDDDDFY EEE-DDDQEE TCCQQPEPPP LVKGPGMMII QLLSSSSLKL TSLLLYYSSW WWWWDDDDFY EEE-DDDQEE KSSQQPEPPP LVKGPGMMII QLLSSSSLKL TSLLLYYSSW WWWWDDDDFY DDD-DDDQEE DSSQQPEPPP LVKGAGMMII QLLSSSSLKL TSLLLYYSSW WWWWDDDDFY EEE-DDDQEE KSSQQPEPPP LVKGAGMMII QLLSSSSLKL TSLLLYYSSW WWWWDDDDFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EEE-DDDEEE KSSQQPEPPP LVKGAGMMII QLLSSSSLKL TSLLLYYSSW WWWWDDDDFY EEE-DDDQEE KSSQQPEPPP LVKGPGMMII QLLSSSSLKI TSLLLYYSSW WWWWDDDDFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EEE-DDDKDD ECCQQPDPPP VVKGPGMMII QLLSSSSLKL TSLLLYYSSW WWWWDDDDFY EEE-DDDKEE ECCQQPDPPP VVKGPGMMII QLLSSSSLKI TSLLLYYSSW WWWWDDDDFY GGG-EEEDGG TWWQQSDVVV PIQGRGMMII QLLTTTTLKL TSLLLFFSSW WWWWDDDDFY KKK-DDDDGG TWWQQSDVVV PIQGRGMMII QLLSSSSLKL TSLLLFFSSW WWWWDDDDFY GGG-EEEDGG SFFQQFDVVV PIKGRGMMII QLLSSSSLKL TSLLLFFSSW WWWWDDDDFY GGG-EEEDGG TFFQQFEVVV PIKGRGMMII QLLSSSSLKL TSLLLFFSSW WWWWVVVVFY TTT-EEEDDD EEEQQYSVVV PVKGRGMMII QLLSSSSLKI TSLLLFFSSW WWWWDDDDFY EEE-GGGEKK ---PPIEAAA LVKGEGMMLL QLLSSSSLKL TSLLLYYKKW WWWWDDDDFY EEE-EEEDHH ---EEIPAAA LVKGEGMMLL QLLSSSSLKL SSLLLYYKKW WWWWDDDDFY ---------- ---------- -----GKKII QLLSSSSVKL TSFFFYYSSW WWWWDDDDFY NNN-DDDPEE KEEAAPEPPP VLKGLGMMLL QLLSSSSLRL SSLLLFFSSW WWWWDDDDFY KKKEDDDKEE KEERRPPAAA RVKGEGMMLL QLLSSSSLKL SSLLLYYSSW WWWWDDDDFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMVV SQQSSSSWKV SSLLLLLAAW WWWWDDDD-- ---------- ---------- ------MMVV SSSSSSSWQL TSLLLLLAAW WWWWDDDD-- YEGGKKWVVK LA---PPSGL LLEEIDKEEE FDF------- RHQRRLLLSG GGDASDYCYP Y-GGRRWAAK VV---PPEGL LLEELEKEEE FDF------- RHQRRLLLWG GGDASDFCYP YDGGPPAVVL AA---PPDGL LLTTLADDDD YEF------- RHQRRLLLEG GGDCSDFCYP YDGGPPVVVM AV---GGNGL LLEELDKDDD YSF------- RHQRRLLLEG GGDCSDFCYP YGDDGGAVVM AV---EENGL LLTTLDKDDD FDF------- RHQRRLLLEG GGDCSDFCYP YEGGDDWVVK LA---PPNGI IIEEFDPKKK FEW------- RHQRRLLLQG GGDCSDYCYP YDGGKKWVVK VV---PPDGM MMQQFDPNNN FDF------- RHQRRLLLQG GGDASDYCFP YVGGRRWAAK AA---PPGGL LLSSLDPGGG FEV------- RHQRRLLLEG GGDSSDYCYP YPDDIIESSV MQVDTVVNGL LLKKLNPNNN FDFPPLLLLP LHERRYYYPG GGDCSDWI-- YPNNIIESSV MQVDTAANGL LLKKLNPNNN FDFPPLLLLP LHERRYYYPG GGDCSDWI-- YPDDIIESSV MQVDTVVKGL LLKKLNPNNN FDFPPLLLLP LHERRYYYPG GGDCSDWL-- YPDDIIESSV MQVDTVVKGL LLTTLNPNNN FDFPPLLLLP LHERRYYYPG GGDCSDWL-- YPDDIIESSV MQVDTVVKGL LLKKLNPNNN FDFPPLLLLP LHERRYYYPG GGDCSDWI-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YPDDIIESSV MQVDTVVKGL LLKKLNPNNN FDFPPLLLLP LHERRYYYPG GGDCSDWI-- YPDDIIESSV MQVDTVVKGL LLKKLNPNNN FDFPPLLLLP LHERRYYYPG GGDCTDWL-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YPDDIIESSV MQVDTEEKGL LLKKLNPNNN FDFPPGGGGP LHERRYYYPG GGDCSDWV-- YPDDLLEAAV MQVDTKKKGL LLKKLNPNNN FDFPPDDDDP LHERRYYYPG GGDCTDWI-- YPGGVVKSSH IQVDTEEKGL LLKKINPNNN FDFPPDDDDP LHERRYYYPG GGDCTDWI-- YPKKVVQSSH IQVDTEENGL LLKKINPNNN FDFPPDDDDP LHERRYYYPG GGDCTDWI-- YPEEMMKSSH IQVDTEEKGL LLSSINPNNN FDFPPEEEEP LHERRYYYPG GGDCTDWI-- YPEEMMKSSH IQGDTEEKGL LLTTINPDDD FDFPPDDDDP LHERRYYYPG GGDCTDWI-- YQDDVVKSSH MQVDTEEKGL LLSSINPNNN FDFPPEEEEP LHERRYYYPG GGDCTDWI-- YPEEVVSAAT MQIDPEESGM MMEEINRDDD FDFEEGGGGP LHERRYYYPG GGDCTDWI-- YPEEVVSAAT MQVDPIITGM MMVVINKNNN FDFPPGGGGP LHERRYYYPG GGDCTDWI-- YPNNVVESSV MQVDTEEKGL LLTTVNKNNN FDFPPNNNNP LHDRRFFFPC CGDSTDLA-- YPEEVVAGGT IQIDVEENGM MMKKLNENNN FDFPPYYYYP LHERR----- ---------- YPKKVVQGGH ILVDTVVNGI IISSLNEDDD FDFPPYYYYP LHERRYYYPG GGDCTDWLAN ---------- ---------- ---------- ---------- ---------- ---------- ------KKKD DQKAYNNWDK KKEELVEDDD FDFGGLLLL- RHIRRFFFGS SSALYS---- ------KKKD DQKLYYYWDK KKEELKEQQQ FDFKKLLLL- RHQRRFFFGA ARALYGAGDG ------- ------- SV----- SV----- SV----- ------- ------- S------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- DA----- ------- ------- NRQRRVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSSKAKKKKA TTPCRTAVVV PPTTLAAADG GGAAMQSLPR TTTAQQLLSS SLLTTTPVVR gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RKAAAAAAQT FAVVVLAASS RSEKRKRVGG LESSAVAQVV VSQAVVWAAH WPPPPPPPKG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AAAAAAEAG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M GGGGGGGKEG ---------- ---------- ---------- ---------- ------LLLK NQQQQQQGLF ---------- ---------- ---------- ---------- ---------- ---------- --------AP TPNNNRTTPP HPNLPAPHRR VLRLVRPRTI IVPPLLCPPP HRRRRRRHLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -KKKKKKREG ---------- ---------- ---------- ---------- ---------- -KKKKKKRIS ---------- ---------- --MMIPPKRD DPPTFFYYSS KKMMAMKKKA APDDLAAAAL ---------- ---------- ----MKKKPD DPPTFFYYTT RRDDAMRRRA APDDIAAAAL ---------- ---------- -----SSRPD DPPTFFHHSS EELLAMQQQA APEEFLLLLL ---------- ---------- -----TTRPD DPPTFFHHSS KKLLAMEEEA APNNFLLLLL ---------- ---------- -----TTRPD DPPTFFYYSS KKLLAMEEEG GPKKLLLLLL ---------- ---------- ----MTTKPD DPPSFFYYSS RRLLAAKKKA APTTIAAAAF ---------- ---------- ----MTTRPD DPPTFFYYSS RRMMAVKKKA APKKLVVVVL ---------- ---------- ----MSSRPD DPPTFFYYSS KKMMAMQQQA APRRLAAAAL ---------- ---------- --TTCKK-CG GPPGYYPPPP EEAAMK---G GPEEIPPPPI ---------- ---------- ---------- ---------- -----M---G GPEEIPPPPI GGGAAAVVVP GGLLLLP--- -ATTCKK-CG GPPGYYPPPP EEAAMK---G GPEEIPPPPI ---------- ---------- ---------- ---------- ----MK---G GPEEIPPPPI ---------- ---------- --TTCNN-CG GPPGYYSSPP EEAAMK---G GPEEIPPPPI GGGAFFTTTV PPMMRRPAAA ASTTCNN-CG GPPGYYSSPP EEAAMK---G GPEEIPPPPI ---------- ---------- --TTCNN-CG GPPGYYSSPP EEAAMK---G G--------- ---------- ---------- --TTCNN-CG GPPGYYSSPP EEAAMK---G GPEEIPPPPI GGGHTTAAAF GGQQLLWEEE EDTTCDD-CG GPPGYYPPPP EEAAMK---G GPEEIPPPPI FFFDQQTTTL YYCCTTLFFF FTTTCNN-CG GPPGYYSSPP EEAAMK---G GPEEIPPPPI ---------- ---------- --TTCNN-CG GPPGYYSSPP EEAAMK---G GPEEIPPPPI LLLQHHIIIA VVEETTAAAA AAKKCHHAKG GPPGYYAAPP EEAAMEKKKG GPKKLTTTTV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AACSS-CG GPPGYYKKPP DDAAMK---G GPEEIPPPPI ---------V HHGGVVVEEE EK--NCCKSG GPPGYYAAPP EESSMS---G GPSSLTTTTV ---------V HHAAVVVEEE EKNNQCCKSG GPPGYYAAPP EEAAMS---G GPTTLTTTTV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RLLVGG GPPGYYAAPP AAAAMS---G GPKKLTTTTV ---------- ----MMAAAA AAAACGGATG GPPGYYAAPP EEAAMEKKKG GPKKLTTTTV ---------- ------MPPP PNLLCGG--G GPPGYYAAPP DDAAIK---G GPEEVTTTTP ---------- ------M--- --LLCGG--G GPPGYYAAPP DDAAIK---G GPEEVTTTTP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMEKKKCG GPPGYYAAPP DDAAVRNNNG GPKKLVVVVV ---------- ---------- ---------- ---------- ----MRSSSG GPKKLVVVVV ---------- ---------- ---------M MPPGLLII-- DDIILISSSL LDFFLNNNNL GGG------- AALLAAA--- -AMMLFFAFA ADDETTCCSS YYMMPKIIIT TGEEFWWWWL SSSGPPSSSA AALLVVSLLL LALLAAAVRA ADDETTCCSS YYMMKKIIIT TGDDYWWWWL LYYTGGTTII NDDFFIAADV NSSSETSKKK IVHVVEEEEP YINNNEEELH GGWASSCC-- LYYVGGTTVV NDDFFLAADV DSSSPTGKKK VIYLLDDDDP YIGGGEEELH GGWASSCC-- LSSPDDFF-- -DDAALAADV KSSSSTGKKK IVHVVTTTTP NTGGGEEEFH GGWASSSS-- LSSPDDFF-- -DDAALAADV KSSSPTGQQQ IVHVVTTTTP NKGGGEEEFH GGWASSSS-- LSSPDDAA-- -DDGGLAADV DSSSEKGQQQ IVHLLIIIIP NKGGGEEEFH GGWASSSS-- FDDPEERR-- -DDAAIAADV DSSSPRASSS IVGVVAAAAP HAGGGEEELH GGWASSCC-- LNNPMMAAGG -DDAAMCCDV DSSSSTGQQQ VVGTTDDDDP YTGGGEEELH GGWASSCC-- LDDPGGRR-- -DDAALGGDL DSSSGTAQQQ IVGVVEEEEP NAAAAEEELH GGWASACC-- IYYRNNTTTT EDDYYLAADV DSSSPQSQQQ VIHLLPPPPP YLKKKEEELH GGWTSS---- IYYRNNTTII EDDYYLAADV DSSSPHSQQQ VIHLLPPPPP HLKKKEEELH GGWTSS---- IYYGNNTTII EDDYYLAADI DSSSPQCQQQ VIHLLPPPPP NLRRREEELH GGWASS---- IYYRNNTTII EDDYYLAADV DSSSPQCQQQ VIHLLPPPPP HLKKKEEELH GGWTSS---- IYYRNNTTTT EDDYYLAADV DSSSPQCQQQ VIHLLPPPPP NLKKKEEELH GGWTSS---- IYYRNNTTTT EDDYYLAADV DSSSPQCQQQ VIE------- ---------- ---------- --------TT EDDYYLAADV DSSSPQCQQQ VIHLLPPPPP NLKKKEEELH GGWTSS---- IYYRNNTTTT EDDYYLAADV DSSSPQCQQQ VIHLLPPPPP NLKKKEEELH GGWTSS---- IYYRNNTTTT EDDYYLAADV DSSSPQSQQQ VIHLLPPPPP YLKKKEEELH GGWTSS---- IYYRNNTTTT EDDYYLAADV DSSSPQCQQQ VIHLLPPPPP NLKKKEEELH GGWTSS---- IYYRNNTTTT EDDYYLAADV DSSSPQCQQQ VIHLLPPPPP NLKKKEEELH GGWTSS---- VYYNGGTTII NDDYYLAADL DSSSPTSQQQ VIHLLPPPPI HIGGGKKKLH GGWSSS---- ---------- ---------- ---------- ---------P NTNNNEEELH GGWTSS---- IYYRSSTTII NDDYYLAADV DSSSPSSQQQ VIHLLPPPPP NVNNNEEELH GGWTSS---- VYYAGGTTII EDDYYLAADV DSSSPTSKKK VIHLLPPPPP YVGGGEEELH GGWSSS---- VYYAGGTTII EDDYYLAADL DSSSPTSKKK VIHLLPPPPP YVGGGEEELH GGWSSS---- ---------- ---------- ---------- ---------P FVGGGEEELH GGWSSS---- VYYTGGTTII DDDYYLAADV DSSSPSSSSS VIHLLPPPPP FVGGGEEELH GGWSSS---- VYYNGGTTII NDDYYLGGDV DSSSPTSQQQ VIHLLPPPPT HVGGGEEELH GGWASS---- P-----NNAA DDDAAIFFDV NSSSDTCQQQ VISVVDDDDP HIGGGEEEVH GGWASS---- P-----HHRR DDDAAIFFNV NSSSETCQQQ IISVVDDDDP NIGGGEEEVH GGWASS---- ---------- ---------- ---------- ---------- ---------- ---------- VQQPNNLLEE EDDYYLAADV DSSSPTCQQQ VIHTTYYYYN SKHHHEEELH GGWTSSFFVV VQQPNNLLEE PDDYYLSSDV DSSSPTCQQQ IVHTTFFFFN RKGGGEEELH GGWASSYYVV LHHGDDIIQQ YTTDDRKKRM VVVVFLGSSS VLKGGPPPPK VLEEEKKKED QQPPIL---- LGGVEEGGGG DDDKKLVVDL RSSSATGQQQ VINVVSSSSG G-RRREEEAH GGFA------ LGGAEEGGGG DDDKKLVVDA NSSSPQGKKK VVNLLSSSSG G-RRREEEAH DDFD------ PPGG-PIIER RRRFIVVVPP GLSSSSRRYY IIIDTTKPRR EKIIKKVEPE EEEEEEVKKV PPAA-PLLER RRRYIVVVPP ALSSSSRRYY VVVDTTKKRR RAAAKKIEPE EEEEVVAVVR PPTTGALLER RRRFIIIIPP GLSSSSRRYY IIIDTTKPTT QRHHKKIEPD DDDDEEILLK PPAAGAIIER RRRYIIIIPP GLSSSSRRYY IIIDTTKPTT KKHHKKIEPE EEEEEEVFFK PPTTGALLER RRRYIIIIPP GISSSSRRYY VVVDVVKPLL KKHHKKIEPE EEEEEEVFFK PPAAPPMMER RRRYVVVVPP GLSSSSRRYY LLLDTTKPLL KFAAKKVEPE EEEETTLAAR PPAAPPVVER RRRYVVVVPP DISSSSHHTT LLLDTTKPTT QKVVKKVDPN NNNNEELAAR PPAAPPVVER RRRYIVVVPP GISSSSRRHH VVVDTTKPRR ERVVKKVEPE EEEEEELHHR --FFGSKKSR RNNKILLLPP GLSSSSRRYY VVVDVVGPRR AKHHKKVEAS SSSSEEIQQK --FFGSKKSR RDDKILLLPP SISSSSRRYY VVVDVVGPRR AKHHKKVEPN NNNNEEIHHK --FFGSKKSR RTTKMLLLPP CLSSSSRRYY VVVDVVGPRR AKHHKKVEAE EEEEDDIHHK --YYGIKKAR RTTKVLLLPP ALSSSSRRYY VVVDVVGPRR AKHHKKVEPK KKKKDDIHHK --FFGSKKSR RTTKVLLLPP SLSSSSRRYY VVVDVVGPRR AKHHKKVEPE EEEEDDIHHK ---------- ---------- ---------- ---------- --------PK KKKKDDIHHK --FFGSKKSR RTTKVLLLPP SLSSSSRRYY VVVDVVGPRR AKHHKKVEPK KKKKDDIHHK --FFGSKKSR RTTKVLLLPP SLSSSSRRYY VVVDVVGPRR AKHHKKVEPK KKKKDDIHHK --FFGSKKSR RNNKVLLLPP SFSSSSRRYY VVVDVVGPRR AKHHKKVEAK KKKKDDIHHK --FFGSKKSR RTTKVLLLPP SL-------- ---------- ---------- ---------- --FFGSKKSR RTTKVLLLPP SLSSSSRRYY VVVDVVGPRR AKHHKKVEPK KKKKDDIHHK --HHGPAAKR RRRFILLLPP SLSSGGRRYY VVVDTTAPRR TSHHKKVESE EEEEDDIAAN --YYGAKKVR RNNKILLLPP CLSSSSRRYY VVVDVVGPRR ARHHKKTEPY YYYYEEVFFK --YYGSKKVR RNNKILLLPP CLSSSSRRYY VVVDVVGPRR ARHHKKTEPY YYYYEEVFFK --HHGPAAER RRRFIAAAPP SLSSGGRRYY IIIDTTKPRR SSHHKKVDPA AAAADDIIIK --HHGPAAQR RRRFIVVVPP GISSGGRRYY IIIDTTKPRR ASHHKKVEPE EEEEDDISSK --HHGAAADR RRRYVLLLPP SLSSGGRRYY IIIDTTKPRR ASYYKKYDPK KKKKEEIAAK --HHGAVVDR RRRYVLLLPP SLSSGGRRYY IIIDTTKPRR ASYYKKYDPK KKKKEEIAAK --HHGPAASR RRRFILLLPP SLSSGGRRYY VVVDTTLPRR AAHHKKVEAE EEEEDDIAAK --HHDPEEKR RSSHIVVVPP CLSSDDRRYY IIINVVE-RR KYEEHHTEPS SSSSKKLHHL --HHDPEEKR RSSHIVVVPP CLSSDDRRYY IIINVVE-RR EYQQHHTEPS SSSSKKLHHL ---------- ----VPPPRR KLSSGGVVGG VVVFVVG--- ---------- ---------- PPGGGEPPTR RDDRVLLLPP CLSSDDRRFF IIIDTTGPRR AKAAKKVEG- ----DDVLLG DDSSSTPPKR RDDRVLLLPP SLSSDDFFYY LLLDVVVPRR KEVVKKTDG- ----DDVLLS ----GRQQGG GPPQLQQQLL SLGGKKRRYY TTTTSSLAWW DQYYPP---- ----DDLIIF --------DR RRRFWTTTGG GLTTNNRRFF FFFDVVHPSS NKHHKKTDT- ----FFVKKS --------DR RRRYWAAAGG GLTTSSKKFF FFFDVVHPAA RVSSKKTTD- ----FFVEES SGGYYRRTHC CGDDDDAAAY IIIALGNNE- GGEGPGIIIL HHHHYSFFEP PLGGGKWIID TGGYYKKTHC CGDDDDAAAY IIIALGGGP- GGEGPGIIIL HHHHDTFFEP PIGGGRWVVY TGGYYRRTHC CGEEEEGGGY VVVTLGGGAK GGDGAPIIIM CCCCETFFDV VLGGGRWIID TGGYYRRTHC CGDDDDGGGY VVVTLGGGGK GGNGPPVVVM CCCCETFFEV VLGGGRWIID TGGYYRRTHC CGEEEEGGGY VVVTLGGGGE GGDGPPIIIL CCCCETFFEI ILGGGRYMMD TGGYYRRTHC CGGGGGGGGY VVVALGNNA- GGKGPGIIIL AAAAQSFFEP PLGGGRWVVE TGGYYRRTHC CGDDDDGGGY IIIALGSSP- GGEGPGIIIL HHHHDNLLEV VLGGGRWIID TGGYYRRTHC CGDDDDGGGY VVVALGSSP- GGDGPGVVVM HHHHESFFDP PLGGGRWVVE CNNVVNNTHC CLSSSSGGGV MMMNTLGGD- QQNGKGFFFL GGGGETFFEV VKGGGTWKKP CNNLLNNTHC CLSSSSGGGV MMMSSLGGD- QQNGKGFFFL GGGGETFFEV VKGGGTWKKP CGGLLYYTHC CLSSSSGGGV MMMSTLGGD- KKNGKGFFFL GGGGETFFEV VKGGGTWQQP CNNLLFFTHC CLSSSSGGGV MMMSTLGGD- EENGKGFFFL GGGGKTFFEV VKGGGTWQQP CEELLFFTHC CLSSSSGGGV MMMSSLGGD- KKNGKGFFFL GGGGETFFEV VKGGGTWRRP CEELLFFTHC CLSSSSGGGV MMMSSLGGD- KKNGKGFFFL GGGGETFFEV VKGGGTWRRP CEELLFFTHC CLSSSSGGGV MMMSSLGGD- KKNGKGFFFL GGGGETFFEV VKGGGTWRRP CEELLFFTHC CLSSSSGGGV MMMSSLGGD- KKNGKGFFFL GGGGETFFEV VKGGGTWRRP CGGLLTTTHC CLTTTTGGGV MMMSTLGGD- KKNGKGFFFL GGGGETFFEV VKGGGTWRRP ---------- ---------- ---------- ---------- ---------- ---------- CEELLFFTHC CLSSSSGGGV MMMSSLGGD- KKNGKDSSSL PPPP-RLLEC CSGGG----- IGGLLFFTHC CLSSSSGGGI MMMSCLGGD- EENAAGGGGL DDDDSEFFNV VKGGGRGNNR CGGLLNNTHC CLCCCCGGGI MMMSSIGGD- YYNGKGFFFL GGGGETFFEV VKGGGNWAAE CGGLLNNTHC CLCCCCGGGI MMMSSLGGD- CCNGKGFFFL GGGGETFFEV VKGGGNWVVE TGGLLYYTHC CLSSSSGGGL MMMSCLGGD- DDNAEGGGGL DDDDSDFFNV VKGGGRWKKP TGGLLYYTHC CLSSSSGGGI MMMSCIGGD- DDNAEGGGGL DDDDSEFFNV VKGGGRWKKP TGGLLYYTHC CLSSSSGGGI LLLSCLGGD- EENAKGGGGL DDDDSDFFNI IKNNNRWKKP TGGLLFFTHC CR----GGGI LLLSCLGGD- EENAKGGGGL DDDDSDFFNI IKNNNRWKKP TGGLLFFTHC CLSSSSGGGI MMMSCLGGD- EENAAGGGGL DDDDSEFFNV VKGGGRWKKP N--LLFFTHC CLDDDDGGGI MMMSTLGGE- NNTPSGFFFL GGGGKTFFEP PKGGGTWAAD N--LLFFTHC CLDDDDGGGI MMMSTLGGE- DDSPSGFFFL GGGGKTFFEP PKGGGTWAAD ---------- ---------- ---------- ---------- ---------- ---------- ADDCCAATHC CLNNNNGGGI MMMSIMGGD- EENAKGDDDE DDDDKNFFEL LVGGGTWRRG HNNVVAATHC CLNNNNGGGI MMMSVMGGD- EEYAKGDDDL DDDDSDFFNC CIGGGTWKKG LVVLLIITDY YQNNNNTTTL KKKDGVNNE- LLVPVLGGGT KKKKHENNGL LSAAAKGAAS GGGVVGGTFA ALGGGGSSSM IIIGLSNND- DDGGRTLLLY DDDDDGEEYV VATTTYWPPT GGGVVGGTYA ALGGGGRRRL IIIGLSNNN- DDGGRTLLLY NNNNAGEEYV VATTTHWPPT GGY------- ---------- YYFFWWWNL- PPPNNEEVLV SSSWWANN-- ---TID-LKL GGY------- ---------- YYFFWWWNL- PPPSSGGVMI TTSWWTRR-- ---CFE-FSL GGD------- ---------- YYFFWWWNL- PPPRRDDYMV SSSWWAPP-- ---QFN-IVP GGT------- ---------- YYFFWWWNL- PPPRRDDYMV TTSWWAPP-- ---QFN-IVP GGT------- ---------- YYFFWWWNL- PPPRRDDYMV SSSWWGPP-- ---QFN-IVP GGY------- ---------- YYGGWWWHL- GGGYYDDTLV TTSWWGDD-- ---MVD-LVP GGY------- ---------- YYFFWWWHL- GGGYYDDTLL TTSWWGRR-- ---MVS-VLG GGQ------- ---------- YYFFWWWHL- GGGYYDDTMV TTSWWGNN-- ---MIG-LDP GGP------- ---------- YYFFWYYQP- RRRHHNNVMV SSTWWANN-- ---VFDFNPA GGP------- ---------- YYFFWYYQP- RRRHHNNIMV SSTWWANN-- ---VFDFNPA GGP------- ---------- YYFFWYYQP- RRRHHNNVMI SSTWWANN-- ---VFDFNPA GGP------- ---------- YYFFWYYQP- RRRHHNNVMI SSTWWANN-- ---VLDFNPA GGP------- ---------- YYFFWYYQP- RRRHHNNVMI SSTWWANN-- ---VLDFNPA GGP------- ---------- YYFFWYYQP- RRRHHNNVMI SSTWWANN-- ---VLDFNPA GGP------- ---------- YYFFWYYQP- RRRHHNNVMI SSTWWANN-- ---VLDFNPA GGP------- ---------- YYFFWYYQP- RRRHHNNVMI SSTWWANN-- ---VLDFNPA GGP------- ---------- YYFFWYYQP- RRRHHNNVMI SSTWWANN-- ---VVNFNPA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --ASSANN-- ---LRTSRDY FFS------- ---------- RRHHLYYENY AAAWWGGLFW SSWQQCLL-- ---FYTAELM EEP------- ---------- YYFFWYYQP- RRRHHNNVMI SSTWWGKK-- ---AFLFKME EEQ------- ---------- YYFFWYYQP- RRRHHNNVMI SSTWWGKK-- ---AFLFKME HHL------- ---------- YYFFWYYQP- RRRHHNNTMI SSTWWGTT-- ---AFKFDLQ HHL------- ---------- YYFFWYYQP- RRRHHNNTMI SSTWWGKK-- ---AFQFNLQ HHL------- ---------- YYFFWYYQP- RRRHHKKTMI SSTWWGKK-- ---AFKFDLQ IIL------- ---------- YYFFWYYQP- RRRHHKKTMI SSTWWGKK-- ---AFKFNLQ HHL------- ---------- YYYYWYYQP- RRRHHKKTMI SSSWWGAA-- ---AFTFDLQ KKP------- ---------- YYFFWYYQP- RRRRRNNVMI SSTWWGNN-- ---HIKFNPA KKP------- ---------- YYFFWYYQP- RRRRRNNIMI SSTWWGNN-- ---HIKFNPA ---------- ---------- ---------- ---------- SSIRRGVV-- ---TVREELK RRL------- ---------- YYYYWYYQP- HHHFFNNVMV AASWWGKK-- ---LFRYHPT KKL------- ---------- YYFFWYYQP- YYYFFDDVMV SSSWWGNN-- ---KWRWKNV FFI------- ---------- LLNNHNNNG- ---RREEKSE SSDPPDII-- ---MAESESF DDQVVAVVVG DAVVAADDDD YYIIRAALI- RRRKKNNVML TTSFFTSSNN YYYMMFQMLQ GGRIIKTTTG -KYYAADDDD YYVVRAALP- RRRKKNNLLV TTSFFTNNNN YYYMMFKMLA LKDYYYIHWW DLKRKKSLTT LGRRM----- LRLHHDKKLM NMMMMVVSSS LLLLSSILWW LKEYYYLHWW DLKRRRAIDD LGRRM----- VRLHHDKKLM NVVVVVLNNN TTLLSSILWW LLAYYYLHWW DLARRRTIDD LGQQM----- VRAHHDRREY GVVVVVVDDD TTLLEGITWW LLSYYYLHWW DLARRRTIDD LGQQM----- VRAHHDRREY GVVVVVVDDD TTLLEAITWW LLSYYYIHWW KLDRKKTIDD LGQQM----- IRAHHDKKDY GVVVVVVDDD TTLLQGITWW LLGYYYLHWW DLRRRREIDD FGQQL----- LRAHHDKKAY NCCCCVISSS LLLLSSITWW LLAYYYLHWW DLRRRRTLDD LGQQM----- LRAHHDKKAY NCCCCVVSSS LLLLSAILWW LLNYYYLHWW DLRRRRALDD VGQQM----- LRAHHDRRTY GVVVVVVSSS LLLLSAVLWW EA-YYYIFWW DWRHEETLQQ MTGGL----L IRLHHDAATQ GCCCCALSSS SSQQRFKEEE EA-YYYIHWW DWRHEETLQQ MKGGL----L IRLHHDAATQ GCCCCALSSS SSQQRFKEGG EA-YYYLHWW DWRHEETLTT LQGGL----L IRLHHNAAAQ GCCCCALSSS SSQQRFKQGG KA-YYYLYWW DWRREETLPP LQGGL----L IRLHHNAAAQ GCCCCALSSS SSQQRFKEDD EA-YYYLYWW DWHHEETLSS LKGGL----L IRLHHNAAAQ GCCCCALSSS SSQQRFKEGG EA-YYYLYWW DWRHEETLSS LKGGL----L IRLHHNAAAQ GCCCCALSSS SSQQRFKEGG EA-YYYLYWW DWRHEETLSS LKGGL----L IRLHHNAAAQ GCCCCALSSS SSQQRFKEGG EA-YYYLYWW DWRHEETLSS LKGGL----L IRLHHNAAAQ GCCCCALSSS SSQQRFKEGG EA-YYYLHWW DWRHEETLLL MPGGH----L IRLHHDAASQ GCCCCALSSS SSQQRFKEGG ---------- ---------- ---------- ---------- ---------- ---------- SA-VVVT--- ---------- ---------- ---------- ---------- ---------- TA-VVVSCDD NYMRVVSLPP LQQQANNNNL LRIHHWIINQ VVVVVEVSSS FFRRGGDDAA QA-YYYLNWW DWEHRRTIDD LGGGL----L IRLHHDAAAQ GCCCCALSSS SSFFRFKKDD QA-YYYLNWW DWEHRRTIDD LGGGL----L IRLHHNAADQ GCCCCALSSS SSFFRFKKDD AD-YYYLTII QLRGEETLDD LGGGL----L IRLHHDKKDT GSSSSALSSS SSIIRFKQDD AD-YYYLHYY SWGGEETLDD LGGGL----L IRLHHDKKDT GSSSSALTTT SSIIRFKQDD AD-YYYLHYY SWGGEELIDD LGGGL----L IRLHHDKKDT GSSSSALSSS SSIIRFKSDD AD-YYYLHYY SWGGEELIDD LGGGL----L IRLHHDKKDT GSSSSALSSS SSIIRFKSDD QD-YYYLHYY DWGGEETLDD LGGGL----L VRLHHDKKDT GCCCCALTTT SSVVRFKADD GE-YYYVHFF EWSKKKTIDD LPGGA----L VRLHHESSEH GCCCCALGGG SSFFRIPEEE PE-YYYVHFF EWTKKKTIDD LPGGA----L VRLHHESSEH GCCCCALGGG SSFFRIPEKK PE-VVVKRYY ---------- ---------- ---------- ---------- ---------- DDRYYYLNYY RWEREETIDD LGGGL----L IRLHHNEENQ GCCCCAFXXX XXXXXX---- EDMYYYLNYY KWTQTTTIDD LGGGI----L IRLHHNKKAE GCCCCALNNN AAFFHFKSDD KTGKKKVAVV L--------- ---------- ---------- ---------- ---------- EAMFFFIVWW DLTRQQVFNN VP-------L IRPWWGAANY TTTTTALTTT SSWWLIEDAA EAMFFFVVWW DLTKQQVFDD VP-------L IRAWWGHHNY STTTTALTTT SSWWLIEGEE WFYYY-EDGG WEEEEKKVVV EEEELLLEG- NPEIIILPFF KAPPPPPVDD DIIISDSRRY WFYYY-EDGG WEEEERRVVV DDQQFFFEG- PPPVVVLDFF KMPPPPPVDD DIIISDSRRY WWRRR-EGGG FKKKKKKTTT TTEEAAATAD EPPLLLLGFF GAPPPPPVDD DILLSDSRRY WWRRR-EGGG FEEEEKKTTT TTEEAAAPKE KPPLLLLGFF GAPPPPPVDD DILLSDSRRY WWQQQKDDGG FKKKKKKTTT TTVVAAADAD DPDLLLLGFF GAPPPPPVDD DILLSDAHHY WYRRR-DKDD WRRRRKKVVV EEEEAAADPD QPPVVVLGFF KAPPPPPVDD DILLSDSLLY WYRRR-DNGG WKKKKKKVVV DDEEAAASED QPPIIILPFF KAPPPPPVDD DILLSDSHHY WHRRR-QNGG WRRRRKKVVV EEEEAAAEPD QPPLLLLDFF GAPPPPPVDD DILLSDSRRY EG-------- ---------- WWKKIIIQVP SKVKKKGMLL PEPPPPGIDD DILLSDSRRY GG-------- ---------- WWKKIIIQVP SKVKKKGMLL PEPPPPGIDD DILLSDSRRY GG-------- ---------- WWKKIIIQVP PKVKKKGMLL PEPPPPGIDD DILLSDSRRY DG-------- ---------- WWKKIIIQVP PKVKKKGMLL PEPPPPGIDD DILLSDSRRY GG-------- ---------- WWKKIIIQVP PKVKKKGLLL PEPPPPGIDD DILLSDSRRY GG-------- ---------- WWKKIIIQVP PKVKKKGLLL PEPPPPGIDD DILLSDSRRY GG-------- ---------- WWKKIIIQVP PKVKKKGLLL PEPPPPGI-- ---------- GG-------- ---------- WWKKIIIQVP PKVKKKGLLL PEPPPPGIDD DILLSDSRRY GG-------- ---------- WWKKIIIEVP PKVKKKGMLL PEPPPPGIDD DILLSDNRRY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AY-------- ---------- VVRRLLLDLY YVVAAAKGVV VSSSSSNFPP PAIIFDL--- DG-------- ---------- WWKKIIIKVP SKVEEEGALL PEPPPPGIDD DIIISDSRRY DG-------- ---------- WWKKIIIQVP SKVEEEGPMM PEPPPPGIDD DIIISDSRRY DG-------- ---------- WWLLIIIPVK PKVQQQNILL PEPPPPGIDD DFIISDVRRY DG-------- ---------- WWIIIIISVE PKVQQQNFLL PEPPPPGIDD DFIISDVRRY DD-------- ---------- WWIIIIISVK PKVEEENILL PEPPPPGIDD DFIISDVRRY DE-------- ---------- WWVVIIISVK PKVEEENILL PEPPPPGIDD DFIISDVRRY DG-------- ---------- WWVVIIISIK PKVRRRNILL PEPPPPGIDD DFIISDVRRY ENSSS----- -----TT--- HHLLAAAFIP SKVSSSGALL PEPPPPAIDD DIIISDSRRY KNPPP----- -----KK--- QQLLAAATIP SKVEEENALL PDPPPPAIDD DIIISDSRRY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -QGEEENEII EMGGGGGMDD DIIISDSRRY DSDDD----- -----EEFFF AAIIIIIPGK LDTGGGSVAA EDGGGGGIDD DIIISDNRRY ---------- ---------- ---------- ---------- ---------- ---------- AG-------- ---------- -------EWQ AAVAAADGNN PAIIIIPPDD DIIIADNRRF EG-------- ---------- -------EWQ AAVAAADGEE PAVVVVPPDD DIIISDNRRF DIPPPFKPLG GGKLLGGGGG FFRRH----- ---------- -AGGKGGQMR RDGGRRRRVY DIPPPHQPLG GGKIIGGGGG YYRRH----- ---------- -SGGEGGQMR RDGGRRRRVY DVPPPHNPLG GGRIIGGGGG AARRH----- ---------- -NGGTGGQMR RDGGRRRRVY DVPPPRKPLG GGHIIGGGGG AARRH----- ---------- -NGGAAAQMR RDGGRRRRVY DVPPPMNPLG GGEIIGGGGG VVKKH----- ---------- -NGGTYYQMR RDGGKKRRVY DVPPPFEPLG GGRIIGGGGG VVRRHG---- ---------- -KNNAGGQMR RDGGRRRRVY DVPPPFNPLG GGQIIGGGGG VVRRH----- ---------- -TSSEGGQMR RDGGRRRRVY DVPPPFNPHG GGRLLGGGGG VVKKH----- ---------- -ASSPGGQMR RDGGRRRRVY DIPPPQKPLG GGFLLGGGGG IIRRSQVLLE --ELTTTQPP PKGGRGGQML LDGGKKRRLY DIPPPKKPLG GGFLLGGGGG IIKKSQVLLE --ELTTTQPP PKGGRGGQML LDGGKKRRLY DIPPPQRPLG GGFLLGGGGG IIKKPQVLLE --ELKKKQPP PKGGKGGQML LDGGKKRRLY DVPPPQRPLG GGFLLGGGGG IIKKPQVLLD --ELDDDQPP PKGGQGGQML LDGGKKRRLY DIPPPQRPLG GGFLLGGGGG IIKKPQVLLE --ELKKKQPP PKGGRGGQML LDGGKKRRLY DIPPPQRPL- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DIPPPQRPLG GGFLLGGGGG IIKKPQVLLE --ELKKKQPP PKGGRGGQML LDGGKKRRLY DIPPPKRPLG GGFLLGGGGG IIKKPQVLLE --ELKKKQPP PKGGRGGQML LDGGKKRRIY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DIPPPRNPLG GGFLLGGGGG IIRRPTVLLE --DLEEEQPP PKGGKGGQML LDGGKKRRLY DITTTRNPLG GGFLLGGGGG IIRRPTVLLE --ELEEEQPP PKGGIGGQML LDGGKKRRIY NILLLKNPLG GGWVVGGGGG IIKKPAAIIG --GKTTTQSV VQGGKGGQML LDGGKKRRLY NIVVVKNPLG GGWAAGGGGG IIKKPVAVVK --GETTTQSV VQGGKGGQML LDGGKKRRLY NIPPPKNPLG GGWVVGGGGG LLKKPKAVVG --GNSSSQFV VKGGSGGQML LDGGKKRRLY NIPPPKNPLG GGWVVGGGGG LLKKPKAVVG --GNTTTQFV VKGGSGGQML LDGGKKRRLY NIPPPAKPLG GGWAAGGGGG LLKKEVYVVT --DKEEEQYV VKGGRGGQML LDGGKKRRIY DIPPPLKVLS SSYIIGGGGG VVTTNKVLLE --K----PIA AKGGKGGQML LDGGKKRRLY DIPPPKNPLS SSFIIGGGGG IISSTKVLLE --HD---EIA AKGGQGGQML LDGGKKRRLY ---------- ---------- ---------- ---------- -----GGAKV VDGGKKRRLY DIRRRANPLG GGFLLGGGGG IIRRPRVLLN --ELKKKAPP PKGGRGGQML LDGGRRRRLY DIPPPENPLG GGFLLGGGGG IISSPVIVVK EEELKKKRPA AKGGRGGQML LDGGKKRRLY ---------- ---------- ---------- ---------- ---------- ---------- DIPPPHKPQY YYVIIDDRRR VV-------- ---------- --------MW WDGGKKRRVY DIPPPHHPQY YYTIIGGAAA VV-------- ---------- --------MW WDGGQQRRLY TNSSLYYYWD NQQFYPPELL KKKGGGGVLN --PSGLLEIK EFVFF----- ---ARRRLSG TNSSLYYYWN NQQFYPP-LL RRRGGGGAVN --PEGLLELK EFVFF----- ---ARRRLWG TNSSLYYYWD DQQFYPPDVV PPPAAAAVAH --PDGLLTLD DWVFFGGG-- ---YRRRLEG TNSSLYYYWD DQQFYPPDVV PPPGGGGVAN --GNGLLELK DFVFFGGG-- ---YRRRLEG TNSSLYYYWD EQQFYPPGRR GGGAAAAVAN --ENGLLTLK DWVFFGGG-- ---YRRRLEG TNSSLYYYVD PQQFYPPEII DDDGGGGVLD --PNGIIEFP KFLWWGGG-- ---HRRRLQG TNSSLYYYWD EQQFYPPDII KKKGGGGVVD --PDGMMQFP NFVFF----- ---QRRRLQG SNSSLYYYWD EQQFYPPVII RRRGGGGAAE --PGGLLSLP GFTVVGGG-- ---LRRRLEG TTSSLYYYWD KQQFY--PLL IIIRRRRSML VDVNGLLKLP NLVFFEEEPP LGGALLLYPG TTSSLYYYWD KQQFY--PLL IIIRRRRSML VDANGLLKLP NLVFFEEEPP LGGALLLYPG TTSSLYYYWD KQQFY--PLL IIIRRRRSML VDVKGLLKLP NLVFFEEEPP LGGALLLYPG TTSSLYYYWD KQQFY--PLL IIIRRRRSML VDVKGLLTLP NLVFFEEEPP LGGALLLYPG TTSSLYYYWD KQQFY--PLL IIIRRRRSML VDVKGLLKLP NLVFFEEEPP LGGALLLYPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TTSSLYYYWD KQQFY--PLL IIIRRRRSML VDVKGLLKLP NLVFFEEEPP LGGALLLYPG TTSSLYYYWD KQQFY--PLL IIIRRRRSML VDVKGLLKLP NLVFFEEEPP LGGALLLYPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TNSSLYYYWD KQQFY--PMM IIIKKKKSML VDEKGLLKLP NLVFFEEEPP GGGVLLLYPG TSSSLYYYWD KQQFY--PLL LLLKKKKAML VDKKGLLKLP NLVFFEEEPP DGGVLLLYPG TNSSLFFFWD KQQFY--PLL VVVEEEESIL VDEKGLLKIP NFVFFEEEPP DGGALLLYPG TNSSLFFFWD KQQFY--PLL VVVEEEESIL VDENGLLKIP NFVFFEEEPP DGGSLLLYPG TNSSLFFFWD RQQFY--PLL MMMDDDDSII VDEKGLLSIP NFVFFEEEPP EGGALLLYPG TNSSLFFFWV VSSFY--PII MMMEEEESII GDEKGLLTIP DFVFFEEEPP DGGSLLLYPG TNSSLFFFWD EQQFYGGQLL VVVKKKKSML VDEKGLLSIP NFVFFEEEPP EGGSLLLYPG TTSSLYYYWD DQQFY--PHH VVVKKKKAMV IDESKMMEIR DLIFFIIIEE GGGYLLLYPG STSSLYYYWD DQQFY--PNN VVVRRRRAML VDITHMMVIK NLIFFVVVPP GGGYLLLYPG TNSSFYYYWD KQQFY--PVV VVVKKKKSML VDEKGLLTVK NLVFFEEEPP NGGCLLLFPC SSSSLFFFWD KQQFY--PMM VVVAAAAGIV IDENGMMKLE NLVFFEEEPP YGGGLLL--- SSSSLYYYWD KQQFY--PMM VVVSSSSGIV VDVNGIISLE DLVFFEEEPP YGGSLLLYPG ---------- ---------- ---------- ---------- ---------- ---------- SSSSLLLLWD ---------- ---KKKKKDA KANWGKKELE DAVFFLLLGG LGG-RRRFGS TSSSLLLLWD ---------- ---KKKKKDE KLYWGKKELE QAIFFEEEKK LGG-RRRFGA GDYP--- GDYP--- GDYPSSR GDYPSS- GDYPSS- GDYP--- GDFP--- GDYPSS- GD----- GD----- GD----- GD----- GD----- ------- ------- GD----- GD----- ------- ------- ------- GD----- GD----- GD----- GD----- GD----- GD----- GD----- GD----- GD----- GD----- ------- GDANDD- ------- SA----- RADGNNV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNNSKKAAA KKKPSSPCRR AVRAADDDGA AAMQQLLPPP RTAQQQSSSS LTTPSPIIKA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AYETFSSSII LLAPPRSSSK KTRRSPLVEE SSAAAAVVKK KQPSSSSSQA AAVWLPPPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----AEEEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---GLGKKKK ---------- ---------- ---------- ---------- ---------- ---NSQGGGG ---------- ---------- ---------- ---------- ---------- ---------- -MGPTLLPLL RRTPPHPPPA ASPPPPVPLL RLVVVVRRYY YRNVVVVVPP PPLHARHHHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MKRRRR ---------- ---------- ---------- ---------- ---------- ----MKRRRR ---------- ---------A VPFFFRDDPP TFYPPPPPSK MAAKKAPPED DLLLAAYCCL ---------- ---------- AKLLLPDDPP TFYPPPPPTR DAARRAPPED DIIIAAYAAL ---------- ---------- MSMMMPDDPP TFHAAAAASE LAAQQAAAEE EFFFAAYLLL ---------- ---------- MTMMMPDDPP TFHAAAAASK LAAEEAAAEN NFFFAAYLLL ---------- ---------- MTLLLPDDPP TFYPPPPPSK LAAEEGVVEK KLLLAAFMML ---------- ---------- ATWWWPDDPP SFYPPPPPSR LAAKKAPPET TIIIAAYMMF ---------- ---------- VTWWWPDDPP TFYPPPPPSR MAAKKAAAEK KLLLAAYRRL ---------- ---------- ASWWWPDDPP TFYPPPPPSK MAAQQARRER RLLLGGYLLL ---------- --------AK TK---CGGPP GYPTTTTTPE AMM--GRREE EIIIVVYCCI ---------- ---------- ---------- ---------- -----GRREE EIIIVVYCCI KHGAAAAVII ARRPGGAASQ GK---CGGPP GYPSSSSSPE AMM--GRREE EIIIVVYCCI ---------- ---------- ---------- ---------- -MM--GRREE EIIIIIYCCI ---------- --------AK GN---CGGPP GYSTTTTTPE AMM--GRREE EIIIVVYCCI AEGAFFFTQQ AQQPIISSAK GN---CGGPP GYSTTTTTPE AMM--GRREE EIIIVVYCCI ---------- --------AK GN---CGGPP GYSTTTTTPE AMM--G---- ---------- ---------- --------AK GN---CGGPP GYSTTTTTPE AMM--GRREE EIIIVVYCCI EPGHTTTAPP LSSWQQDDAK GD---CGGPP GYPTTTTTPE AMM--GRREE EIIIVVYCCI LGFDQQQTTT HTTLVVTTPK GN---CGGPP GYSTTTTTPE AMM--GRREE EIIIVVYCCI ---------- --------AK GN---CGGPP GYSTTTTTPE AMM--GRREE EIIIVVYCCI LVLQHHHIEE AAAAAAAAGT CHTTTKGGPP GYATTTTTPE AMMKKGRREK KLLLVVYCCV ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MK GS---CGGPP GYKSSSSSPD AMM--GRREE EIIIVVYCCI --------AA LDDVNNKKSV GCCCCSGGPP GYASSSSSPE SMM--GRRES SLLLIIYAAV --------GG LQQVSSKKNQ GCCCCSGGPP GYASSSSSPE AMM--GRRET TLLLIIYAAV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MLQQQGGGPP GYATTTTTPA AMM--GSSEK KLLLIIYAAV ---------- ---AAAAAGA CGGGGTGGPP GYATTTTTPE AMMKKGRREK KLLLLLYCCV ---------- ---MSSNNGK HG----GGPP GYASSSSSPD AII--GRREE EVVVLLFAAP ---------- ---MPP--PK HG----GGPP GYASSSSSPD AII--GRREE EVVVLLFAAP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------S SKCCCCGGPP GYATTTTTPD AVVNNGVVEK KLLLLLYCCV ---------- ---------- ---------- ---------- -MMSSGRREK KLLLLLYTTV ---------- ---------- ------MMPP GLITTTTT-D ILLSSLDDRF FLLLYYFWWL EFG------- ---AGGAAAG PFRRRFAADD ETCQQQQQSY MPPIITQQEE EFFFVVYTTL IVSGPPPSHH LRRSGGAAAA PAGGGRAADD ETCAAAAASY MKKIITQQED DYYYVVYTTL LYYTTGGINR DDFIAAVDVN NPKSSYKKII VVVVKKVELP NDDDELLLHH HHFGGWAACS LYYVVGGVNA DDFLAAVDVD DPKSSYKKVV IIIIKKLDLP GDDDELLLHH HHFGGWAACS LSSPPDD--R DDALAAVDVK KPGSSYKKII VVVVTTVTMP GDDDEFFFHH HHFGGWAACS LSSPPDD--K DDALAAVDVK KPGSSYQQII VVVVTTVTMP GDDDEFFFHH HHFGGWAACS LSSPPDD--K DDGLAAVDVD DPTSSFQQII VVVVQQLIMP GDDDEFFFHH HHFGGWAACS FDDPPEE--Q DDAIAAVDVD DPASSYSSII VVVVQQVAMP GDDDELLLHH HHFGGWAACS LNNPPMMG-K DDAMCCVDVD DSQSSFQQVV VVVVVVTDMP GGGGELLLHH HHFGGWAACS LDDPPGG--R DDALGGVDLD DPDSSYQQII VVVVRRVEMP ADDDELLLHH HHFGGWAACS IYYRRNNTEA DDYLAATDVD DPKSSYQQVV IIIIRRLPMP KDDDELLLHH HHSGGWTTCS IYYRRNNIEA DDYLAATDVD DPKSSYQQVV IIIIRRLPMP KDDDELLLHH HHSGGWTTCS IYYGGNNIEA DDYLAATDID DPKSSYQQVV IIIIRRLPMP RDDDELLLHH HHSGGWAACS IYYRRNNIEA DDYLAATDVD DPKSSYQQVV IIIIRRLPMP KDDDELLLHH HHSGGWTTCS IYYRRNNTEA DDYLAATDVD DPKSSYQQVV IIIIRRLPMP KDDDELLLHH HHSGGWTTCS IYYRRNNTEA DDYLAATDVD DPKSSYQQVV IIII------ ---------- ---------- -------TEA DDYLAATDVD DPKSSYQQVV IIIIRRLPMP KDDDELLLHH HHSGGWTTCS IYYRRNNTEA DDYLAATDVD DPKSSYQQVV IIIIRRLPMP KDDDELLLHH HHSGGWTTCS IYYRRNNTEA DDYLAATDVD DPKSSYQQVV IIIIRRLPMP KDDDELLLHH HHSGGWTTCS IYYRRNNTEA DDYLAATDVD DPKSSYQQVV IIIIRRLPMP KDDDELLLHH HHSGGWTTCS IYYRRNNTEA DDYLAATDVD DPKSSYQQVV IIIIRRLPMP KDDDELLLHH HHSGGWTTCS VYYNNGGINK DDYLAATDLD DPSSSYQQVV IIIIRRLPVI GDDDKLLLHH HHSGGWSSCS ---------- ---------- ---------- --------MP NDDDELLLHH HHSGGWTTCS IYYRRSSINK DDYLAATDVD DPKSSYQQVV IIIIRRLPMP NDDDELLLHH HHSGGWTTCS VYYAAGGIEK DDYLAATDVD DPSSSYKKVV IIIIRRLPVP GDDDELLLHH HHTGGWSSCS VYYAAGGIEK DDYLAATDLD DPNSSYKKVV IIIIRRLPVP GDDDELLLHH HHTGGWSSCS ---------- ---------- ---------- --------MP GDDDELLLHH HHSGGWSSCS VYYTTGGIDK DDYLAATDVD DPSSSYSSVV IIIIRRLPMP GDDDELLLHH HHSGGWSSCS VYYNNGGINK DDYLGGTDVD DPNSSYQQVV IIIIRRLPVT GDDDELLLHH HHSGGWAACS P------ADG DDAIFFTDVN NPESSFQQVV IIIIRRVDVP GDDDEVVVHH HHTGGWAACS P------RDG DDAIFFTNVN NPESSFQQII IIIIRRVDVP GDDDEVVVHH HHTGGWAACS ---------- ---------- ---------- ---------- ---------- ---------- VQQPPNNEEH DDYLAATDVD DPASSYQQVV IIIIRRTYTN HNNNELLLHH HHSGGWTTCS VQQPPNNEPH DDYLSSTDVD DPESSYQQII VVVVRRTFTN GDDDELLLHH HHSGGWAACS LHHGGDDQYD TTDRKKNRMV VGQVVGSSVV LLLLDDGPVK EDDDKEEELL LDSQQPPPRI LGGVVEEGDE DDKLVVTDLR RPGSSRQQVV IIIISSVSVG RNNNEAAAHH HHGGGFAA-- LGGAAEEGDE DDKLVVTDAN NPKSSYKKVV VVVVTTLSVG RNNNEAAAHH HHSDDFDD-- SSAAPNNGGK PELLLVVPGL LSSSYIIIDD TTPRRREEPV VVIEEPEEVV KKVSGGGYSS SSAAPNNAAK PELLLVVPAL LSSSYIIVDD TTPRRRRRPI IIVEEPVVAA GGRTGGGYTT SSSSPLLTTH AELLLIIPGL LSSSYVVIDD TTPTTTQQAI IIIEEPEEII AAKTGGGYSS SSAAPLLAAH AELLLIIPGL LSSSYIIIDD TTPTTTKKAI IIIEEPEEVV KKKTGGGYSS SSAAPLLTTH AELLLIIPGI ISSSYIIVDD VV-LLLKKAI IIIEEPEEVV AAKTGGGYSS SSCCPNNAAH PELLLVVPGL LSSSYIILDD TTPLLLKKPV VVIEEPTTLL EERTGGGYSS SSMMPNNAAH PELLLVVPDI ISSSTIILDD TTPTTTQQPV VVIDDPEELL EERTGGGYAA AAAAPYYAAH PELLLVVPGI ISSSHIIVDD TTPRRREEPV VVIEEPEELL RRRTGGGYSS SSCC---FFD SSLLLLLPGL LSSSYVVVDD VVSRRRAAPV VVIEEAEEII AAKCNNNVSS SSCC---FFD SSLLLLLPSI ISSSYVVVDD VVSRRRAAPV VVIEEPEEII AAKCNNNLGG SSCC---FFD SSLLLLLPCL LSSSYVVVDD VVSRRRAAPV VVIEEADDII AAKCGGGLGG SSCC---YYD IALLLLLPAL LSSSYVVVDD VVTRRRAAPV VVIEEPDDII TTKCNNNLGG SSCC---FFD SSLLLLLPSL LSSSYVVVDD VVSRRRAAPV VVIEEPDDII AAKCEEELAA ---------- ---------- ---------- ---------- -----PDDII AAKCEEELAA SSCC---FFD SSLLLLLPSL LSSSYVVVDD VVSRRRAAPV VVIEEPDDII AAKCEEELAA SSCC---FFD SSLLLLLPSL LSSSYVVVDD VVSRRRAAPV VVIEEPDDII AAKCEEELAA SSCC---FFD SSLLLLLPSF FSSSYVVVDD VVTRRRAAPV VVIEEADDII EEKCGGGLGG SSCC---FFD SSLLLLLPSL L--------- ---------- ---------- ---------- SSCC---FFD SSLLLLLPSL LSSSYVVVDD VVSRRRAAPV VVIEEPDDII AAKCEEELAA SSCC---HHD PKLLLLLPSL LSSGYVVVDD TTTRRRTTPV VVVEESDDII EENIGGGLGG SSCC---YYD AVLLLLLPCL LSSSYVVVDD VVTRRRAAPT TTVEEPEEVV WWKCGGGLAA SSCC---YYD SVLLLLLPCL LSSSYVVVDD VVSRRRAAPT TTVEEPEEVV WWKCGGGLAA SSCC---HHD PELLLAAPSL LSSGYVVIDD TTTRRRSSPV VVVDDPDDII QQKTGGGLAA SSCC---HHD PQLLLVVPGI ISSGYVVIDD TTTRRRAAPV VVVEEPDDII TTKTGGGLAA SSCC---HHD ADLLLLLPSL LSSGYAAIDD TTERRRAAPY YYVDDPEEII EEKTGGGLAA SSCC---HHD ADLLLLLPSL LSSGYAAIDD TTERRRAAPY YYVDDPEEII DDKTGGGLAA SSCC---HHD PSLLLLLPSL LSSGYVVVDD TTKRRRAAPV VVVEEADDII EEKTGGGLGG SSCC---HHK PKLLLVVPCL LSSDYIIINN VVNRRRKKIT TTIEEPKKLL SSLN---LSS SSCC---HHK PKLLLVVPCL LSSDYVVINN VVNRRREEIT TTIEEPKKLL AALN---LSS ---------- --MMMPPRKL LSSGGKKVFF VVG------- ---------- ---------- SSCCP--GGK ETLLLLLPCL LSSDFVVIDD TTTRRRAAPV VVIEEGDDVV KKGADDDCTT SSCCDEESSK TKLLLLLPSL LSSDYIILDD VVTRRRKKPT TTIDDGDDVV KKSHNNNVTT LLKK-----K RGMMMQQLSL LGGKYVVTTT SSYWWWDDK- ------DDLL KKFLVVVLAA ---------- -DFFFTTGGL LTTNFIIFDD VVSSSSNNPT TTIDDTFFVV DDSGGGGVVV ---------- -DLLLAAGGL LTTSFVVFDD VVSAAARRPT TTITTDFFVV KKSGGGGVVV RRRLTVHHPD DAIIIIAAAA LLGN---GGP GGILLLHSFE EPKKKDRGGD D--------- KKKYTVHHPD DAIIIIAAAA LLGG--RGGP GGILLLHTFE EPRRRYRGGP P--------- RRRPTVHHPE EGVVVVTTTT LLGGKKTGGA PGIMMMCTFD DVRRRDRGGP P--------- RRRPTIHHPD DGVVVVTTTT LLGGKKTGGP PGVMMMCTFE EVRRRDRGGP P--------- RRRPTIHHPE EGVVVVTTTT LLGGEETGGP PGILLLCTFE EIRRRDRGGE E--------- RRRPTVHHPG GGVVVVAAAA LLGN---GGP GGILLLASFE EPRRRERGGP P--------- RRRPTVHHPD DGIIIIAAAA LLGS---GGP GGILLLHNLE EVRRRDRGGD D--------- RRRPTIHHPD DGVVVVAAAA LLGS---GGP GGVMMMHSFD DPRRRERGGP P--------- NNNTTSHHAS SGMMMMNNNN TTLG--GGGK GSFLLLGTFE EVTTTPGGGA A--------- NNNLTSHHAS SGMMMMSSSS SSLG--GGGK GGFLLLGTFE EVTTTPGGGE E--------- YYYVTSHHAS SGMMMMSSSS TTLG--GGGK GGFLLLGTFE EVTTTPGGGA A--------- FFFFTSHHPS SGMMMMSSSS TTLG--GGGK GGFLLLGTFE EVTTTPGGGA A--------- FFFLTSHHAS SGMMMMSSSS SSLG--GGGK GGFLLLGTFE EVTTTPGGGA A--------- FFFLTSHHAS SGMMMMSSSS SSLG--GGGK GGFLLLGTFE EVTTTPGGGA A--------- FFFLTSHHAS SGMMMMSSSS SSLG--GGGK GGFLLLGTFE EVTTTPGGGA A--------- FFFLTSHHAS SGMMMMSSSS SSLG--GGGK GGFLLLGTFE EVTTTPGGGA A--------- TTTPTSHHPT TGMMMMSSSS TTLG--GGGK GGFLLLGTFE EVTTTPGGGS S--------- ---------- ---------- ---------- ---------- ---------- ---------- FFFLTSHHAS SGMMMMSSSS SSLG--GGGK DGSLLLPRLE EC-------- ---------- FFFPTSHHAS SGMMMMSSSS CCLG--GAAA GNGLLLDEFN NVRRRRLFFP P--------- NNNLTSHHGC CGMMMMSSSS SSIG--GGGK GGFLLLGTFE EVNNNEGEEA A--------- NNNPTSHHGC CGMMMMSSSS SSLG--GGGK GGFLLLGTFE EVNNNEGEES S--------- YYYPTSHHAS SGMMMMSSSS CCLG--GAAE GNGLLLDDFN NVRRRPGHHS S--------- YYYPTSHHAS SGMMMMSSSS CCIG--GAAE GNGLLLDEFN NVRRRPGHHS S--------- YYYPTAHHAS SGLLLLSSSS CCLG--GAAK GNGLLLDDFN NIRRRPGHHS S--------- FFFPTAHHT- -GLLLLSSSS CCLG--GAAK GNGLLLDDFN NIRRRPDIIS S--------- FFFPTSHHAS SGMMMMSSSS CCLG--GAAA GNGLLLDEFN NVRRRPGHHS S--------- FFFPTSHHAD DGMMMMSSSS TTLG--GPPS GNFLLLGTFE EPTTTDEKKT T--------- FFFPTSHHAD DGMMMMSSSS TTLG--GPPS GNFLLLGTFE EPTTTDGKKV V--------- ---------- ---------- ---------- ---------- ---------- ---------- AAAPTTHHPN NGMMMMSSSS IIMG--GAAK G-DEEEDNFE ELTTTGDRRK K--------- AAAPTTHHAN NGMMMMSSSS VVMG--GAAK G-DLLLDDFN NCTTTGDKKK K--------- IIISTADDPN NTKKKKDDDD GGVN--SPPV LNGTTTKENG GLKKKSQFFE E--------- GGGPTFFFPG GSIIIIGGGG LLSN--HGGR TALYYYDGEY YVYYYTADDD DGGGGAAAVA GGGPTLYYPG GRIIIIGGGG LLSN--HGGR TALYYYNGEY YVHHHTDGGD DGGGGAAAIK -------LLY YDFWWWWNL- VLSSEWAPPP P---TD-LLL EHDRRYYRRI HHFDLKRRII -------FFY YDFWWWWNL- VMTSEWTPPP P---CE-LLL ECEAAYYKKL HHVDLKRHLL -------KKY YDFWWWWNL- YMSSEWAPPP P---QN-PPP EDAKKYYRRL HHFDLARNVV -------LLY YDFWWWWNL- YMTSEWAPPP P---QN-PPP EDSKKYYRRL HHFDLARNVV -------KKY YDFWWWWNL- YMSSEWGPPP P---QN-PPP EDSKKYYKKI HHFKLDRNVV -------FFY YDGWWWWHL- TLTSEWGPPP P---MD-PPP DIGRRYYRRL HHFDLRRHLL -------LLY YDFWWWWHL- TLTSEWGPPP P---MS-GGG DEAKKYYRRL HHVDLRRHLL -------LLY YDFWWWWHL- TMTSEWGPPP P---MG-PPP QINGGYYRRL HHIDLRRHLL -------MMY YDFWYYYQP- VMSTEWAPPP P---VDFAAA HV-LLYYRRI FFVDWRHIII -------MMY YDFWYYYQP- IMSTEWAPPP P---VDFAAA HV-LLYYHHI HHVDWRHIII -------MMY YDFWYYYQP- VMSTEWAPPP P---VDFAAA DV-LLYYHHL HHVDWRHIII -------LLY YDFWYYYQP- VMSTEWAPPP P---VDFAAA DV-LLYYHHL YYVDWRRIVV -------SSY YDFWYYYQP- VMSTEWAPPP P---VDFAAA DV-LLYYHHL YYVDWHHIVV -------LLY YDFWYYYQP- VMSTEWAPPP P---VDFAAA DV-LLYYHHL YYVDWRHIVV -------LLY YDFWYYYQP- VMSTEWAPPP P---VDFAAA DV-LLYYHHL YYVDWRHIVV -------LLY YDFWYYYQP- VMSTEWAPPP P---VDFAAA DV-LLYYHHL YYVDWRHIVV -------MMY YDFWYYYQP- VMSTEWAPPP P---VNFAAA DV-LLYYHHL HHVDWRHIVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---AISASSS S---LTSYYY PA-RRVVIIT ---------- -------KKR RTHLYYYENY LFSWIQCSSS S---FTAMMM CL-GGVVIIS CCLNYMRIDD -------FFY YDFWYYYQP- VMSTEWGPPP P---ALFEEE EV-MMYYSSL NNVDWEHRII -------FFY YDFWYYYQP- VMSTEWGPPP P---ALFEEE DV-HHYYSSL NNVDWEHLVV -------FFY YDFWYYYQP- TMSTSWGPPP P---AKFQQQ HV-LLYYHHL TTCQLRGLRR -------FFY YDFWYYYQP- TMSTSWGPPP P---AQFQQQ HV-LLYYHHL HHVSWGGIKK -------FFY YDFWYYYQP- TMSTSWGPPP P---AKFQQQ HV-LLYYHHL HHVSWGGMKK -------YYY YHFWYYYQP- TMSTSWGPPP P---AKFQQQ HV-LLYYHHL HHVSWGGIKK -------FFY YDYWYYYQP- TMSSSWGPPP P---ATFQQQ HV-LLYYHHL HHVDWGGLKK -------FFY YDFWYYYQP- VMSTEWGPPP P---HKFAAA HV-LLYYSSV HHIEWSKYLL -------FFY YDFWYYYQP- IMSTEWGPPP P---HKFAAA HV-LLYYSSV HHIEWTKHLL ---------- ---------- --SILRGPPP P---TREKKK CQ-LLVVCCK RRV------- -------CCY YDYWYYYQP- VMASEWGPPP P---LRYTTT DCRQQYYRRL NNFRWERLFF -------CCY YDFWYYYQP- VMSSEWGPPP P---KRWVVV DLMQQYYRRL NNFKWTQLYY -------LLL LSNHNNNNG- KSSDRPDPPP P---MESFFF LKGLLKKHHV AAEL------ GGDDVAGYYY YDIRAAALI- VMTSSFTWWW WYYYMFQQQQ DAMRRFFTTI VVQDLTRPKK GG--YAGYYY YDVRAAALP- LLTSSFTWWW WYYYMFKAAA DPMHHFFTTV VVTDLTKPKK HTTTEEERMA AALL----RP LLHHDDTLII INMMVSLKLL LSSSWLLLWW F-EDDWWEKV YDDDQQQRMV VVLL----RP LLHHDDTLVV VNVVLNTKLL LSSSWLLLWW F-EDDWWERV QDDDAAAQMA AALL----RP AAHHDDVEVV VGVVVDTTLL LEEEWTTTWW W-EGGFFKKT QDDDAAAQMA AALL----RP AAHHDDVEVV VGVVVDTTLL LEEEWTTTWW W-EGGFFEKT QDDDAAAQMA AALL----RP AAHHDDSDCC CGVVVDTTLL LQQQFTTTWW WKDDDFFKKT QDDDDDDQLV VVFF----RP AAHHDDTAVV VNCCISLKLL LSSSWTTTWW Y-DKKWWRKV QDDDAAAQMA AALL----RP AAHHDDTAMM MNCCVSLKLL LSSSWLLLWW Y-DNNWWKKV QDDDEEEQMV VVLL----RP AAHHDDATVV VGVVVSLELL LSSSWLLLWW H-QNNWWRKV QQQQ---GLI IIPP--LLRF LLHHDDSTVV VGCCLSSNQQ QRRRNEEEEE G--------- QQQQ---GLI IIPP--LLRF LLHHDDDTVV VGCCLSSNQQ QRRRNEEEGG G--------- QTTT---GLI IIPP--LLRF LLHHNNDAVV VGCCLSSTQQ QRRRNQQQGG G--------- QPPP---GLI IIPP--LLRF LLHHNNDAVV VGCCLSSTQQ QRRRNEEEDD G--------- QSSS---GLI IIPP--LLRF LLHHNNDAVV VGCCLSSTQQ QRRRNEEEGG G--------- QSSS---GLI IIPP--LLRF LLHHNNDAVV VGCCLSSTQQ QRRRNEEEGG G--------- QSSS---GLI IIPP--LLRF LLHHNNDAVV VGCCLSSTQQ QRRRNEEEGG G--------- QSSS---GLI IIPP--LLRF LLHHNNDAVV VGCCLSSTQQ QRRRNEEEGG G--------- QLLL---GHI IIPP--LLRF LLHHDDASVV VGCCLSSTQQ QRRRNEEEGG G--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EPPP---QAG GGAANILLRS IIHHWWNNDD DVVVVSFSRR RGGGPDDDAA Y--------- QDDDEEEGLI IIPP--LLRF LLHHDDDAVV VGCCLSSTFF FRRREKKKDD G--------- QDDDKKKGLI IIPP--LLRF LLHHNNDDVV VGCCLSSSFF FRRREKKKDD G--------- QDDDNNNGLL LLPP--LLRF LLHHDDADVV VGSSLSSNII IRRRTQQQDD G--------- QDDDDDDGLL LLPP--LLRF LLHHDDADVV VGSSLTSNII IRRRTQQQDD G--------- QDDDEEEGLL LLPP--LLRF LLHHDDSDVV VGSSLSSNII IRRRNSSSDD D--------- QDDDPPPGLL LLPP--LLRF LLHHDDSDVV VGSSLSSNII IRRRNSSSDD E--------- QDDDSSSGLL LLPP--LLRF LLHHDDSDVV VGCCLTSNVV VRRRTAAADD G--------- QDDDQQQGAL LLPP--LLRF LLHHEETEVV VGCCLGSGFF FRRRVEEEEE N-------T- QDDDMMMGAL LLPP--LLRF LLHHEETEVV VGCCLGSAFF FRRRDEEEKK N-------K- ---------- ---------- ---------- ---------- ---------- ---------- QDDDDDDGLT TTPP--LLRF LLHHNNRNVV VGCCFXXXXX XXXX------ ---------- QDDDSSSGIT TTPP--LLRF LLHHNNKAVV VGCCLNAKFF FHHHKSSSDD S-------EF ---------- ---------- ---------- ---------- ---------- ---------- KNNNGGG--- ------LLRF PPWWGGNNSS STTTLTSQWW WLLLDDDDAA G--------- KDDDGGG--- ------LLRC AAWWGGANTT TSTTLTSQWW WLLLDGGGEE G--------- IIPAELNLLP EEEILLKPPP FVVLLVVVDD DDILLDDKFL LYLWWGIGRQ YYDDIIFKKV IIEAQFPLLP PPPVLLKDDD FVVLLVVVDD DDILLDDRFL LYVWWGLGRQ YYDDIIHQQR AAPAEAELLP PPPLLLQGGG FVVLLVVVDD DDLLLDDRFL LYVWWGTGRQ YYDDVVHNNV AAPPEAKLLP PPPLLLQGGG FVVLLVVVDD DDLMMDDRFL LYVWWGTGRQ YYDDVVRKKK IIDPVADLLP DDDLLLKGGG FCCLLVVVDD DDLLLDDKYL LYVWWGLGHQ YYDDVVMNNV IIPAEAQLLP PPPVLLKGGG FVVLLVVVDD DDLMMDDRFL LYVWWGTGLQ YYDDVVFEEK IIPAEAQLLP PPPILLKPPP FVVLLVVVDD NNLVVDDRFL LYVWWGTGHQ YYDDVVFNNR IIPAEAQLLP PPPLLLKDDD FVVLLVVVDD NNLLLDDRFL LYVWWGTGRQ YYDDVVFNNR TTVEKISKKK VVVKGGWMMM LMMLLIIIDD LLLLLDDRFL LYFWWLHGRQ YYDDIIQKKR TTVEKISKKK VVVKGGWMMM LMMLLIIIDD LLLLLDDRFL LYFWWLHGRQ YYDDIIKKKR TTVEKIPKKK VVVKGGWMMM LMMLLIIIDD LLLLLDDRFL LYFWWLHGRQ YYDDIIQRRR TTAQKIPKKK VVVKGGWMMM LMMLLIIIDD LLLLLDDHFL LYFWWLHGRQ YYDDVVQRRR TTVEKIPKKK VVVKGGWLLL LMMLLIIIDD LLLLLDDRFL LYFWWLHGRQ YYDDIIQRRR TTVEKIPKKK VVVKGGWLLL LMMLLIIIDD LLLLLDDRFL LYFWWLHGRQ YYDDIIQRRR TTVEKIPKKK VVVKGGWLLL LMMLLIII-- ---------- ---------- ---------- TTVEKIPKKK VVVKGGWLLL LMMLLIIIDD LLLLLDDRFL LYFWWLHGRQ YYDDIIQRRR TTVEKIPKKK VVVKGGWMMM LMMLLIIIDD LLLLLDDRFL LYFWWLHGRQ YYDDIIKRRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AALKRLYAAV VVVAKKFGGG VLLEEFFFPP WWIFFDDLLI IIF------- ---------- KKAEKISKKK VVVEGGWAAA LMMLLIIIDD LLILLDDRFL LYFWWLHGRQ YYDDIIRNNK KKAEKISKKK VVVEGGWPPP MMMLLIIIDD LLILLDDRFL LYFWWLHGRQ YYDDIIRNNK SSHELIPLLK VVVQNNWIII LMMLLIIIDD LLILLDDRFL LYFWWLHGRQ YYNNIIKNNV SSHEIIPLLK VVVQNNWFFF LMMLLIIIDD LLILLDDRFL LYFWWLHGRQ YYNNIIKNNK TTYEIIPLLK VVVENNWIII LMMLLIIIDD LLILLDDRFL LYFWWLHGRQ YYNNIIKNNV TTHEVIPLLK VVVENNWIII LMMLLIIIDD LLILLDDRFI IYFWWLHGRQ YYNNIIKNNV SSHEVIPLLK VVVRNNWIII LMMLLIIIDD VVILLDDRYL LYLWWLHGRQ YYNNIIAKKV TTATLASKKK VVVSGGWAAA LMMLLIIIDD LLIMMDDRFL LYVWWLHGRQ YYDDIILKKK VVASLASKKK VVVENNWAAA LMMLLIIIDD LLIMMDDRFL LYVWWLHGRQ YYDDIIKNNK ---------- ---------- ---------- ---------- ---------- ---------- ---------Q GGGENNGEEE IMMMMMMMDD LLILLDDRYL LYFWWRHGRQ YYDDIIANNR EEKVIILVVD TTTGSSGVVV AMMMMIIIDD IIILLDDRFL LYVWWRHGRQ YYDDIIENNK ---------- ---------- ---------- ---------- ---------- ---------- ------AKKA VVVADDIGGG NDDLLPPPDD SSIAADDQTL LWIFFMDGRL FFDDIIHKKF ------AKKA VVVADDIGGG EKKLLPPPDD SSINNDDSRL LWVFFMDGRL FFDDIIHHHR LTTTKVKGIF FHHHH----- ---------- ----GGHKLL TTTAQQMMLE DDGRRRVYYS LAAARVKGLY YHHHH----- ---------- ----GGAEAA TTTAQQMMIS DDGRRRVYYS LAAASVRGIA ARRRR----- ---------- ----GGRTFF AAAGQQMMVE DDGRRRVYYS LAAASVHGIA ARRRR----- ---------- ----GGKAFF AAAGQQMMVE DDGRRRVYYS LTTTKVEGIV VKKKK----- ---------- ----GGKTFF GGGGQQMMVE DDGKRRVYYS LTTTKVRGIV VSSSSG---- ---------- --AANNGALL NNNGQQMMVE DDGRRRVYYS LTTTKVQGIV VRRRR----- ---------- --AASSAELL NNNGQQMMVE DDGRRRVYYS HTTTSVRGIV VRRRR----- ---------- ----SSGPLL NNNGQQMMVE DDGRRRVYYS LTTTQIFGSI IVVVVQVLLL LLEE-QQTCE PLVVGGKRII PPPGQQMMIQ DDGKRRLYYS LTTTQIFGSI IVVVVQVLLL LLEE-QQTCE PLVVGGKRVV PPPGQQMMIQ DDGKRRLYYS LTTTQLFGSI IVVVVQVLLL LLEE-QQKSE PLVVGGKKVV PPPGQQMMIQ DDGKRRLYYS LTTTQLFGSI IVVVVQVLLL LLDD-QQDSE PLVVGGKQVV AAAGQQMMIQ DDGKRRLYYS LTTTQLFGSI IVVVVQVLLL LLEE-QQKSE PLVVGGKRVV AAAGQQMMIQ DDGKRRLYYS L--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LTTTQLFGSI IVVVVQVLLL LLEE-EEKSE PLVVGGKRVV AAAGQQMMIQ DDGKRRLYYS LVVVQIFGSI IVVVVQVLLL LLEE-QQKSE PLVVGGKRVV PPPGQQMMIQ DDGKRRIYYS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LVVVQIFGSI ILLLLTVLLL LLEE-KKECD PVVVGGKKVV PPPGQQMMIQ DDGKRRLYYS LVVVQIFGSI IQQQQTVLLL LLEE-KKECD PVVVGGKIII PPPGQQMMIQ DDGKRRIYYS LTTTQLWGLI IQQQQAAIII IIGG-DDTWD VPIIGGQKLL RRRGQQMMIQ DDGKRRLYYS LTTTQVWGLI IQQQQVAVVV VVKK-DDTWD VPIIGGKKLL RRRGQQMMIQ DDGKRRLYYS LTTTQIWGLL LQQQQKAVVV VVGG-DDSFD VPIIGGKSLL RRRGQQMMIQ DDGKRRLYYS LTTTQIWGLL LQQQQKAVVV VVGG-DDTFE VPIIGGKSLL RRRGQQMMIQ DDGKRRLYYS LAAAQVWGLL LQQQQVYVVV VVTT-DDEES VPVVGGHRLL RRRGQQMMIQ DDGKRRIYYS LNNNQVYGSV VHHHHKVLLL LLEE-EE--E ALVVGGRKII EEEGQQMMLQ DDGKRRLYYS LNNNQVFGSI IHHHHKVLLL LLEE-DD--P ALVVGGRQII EEEGQQMMLQ DDGKRRLYYS ---------- ---------- ---------- ---------- ---GAAKKIQ DDGKRRLYYS LTTTQVFGAI IQQQQRVLLL LLNN-PPKEE PVLLGGRRLL LLLGQQMMLQ DDGRRRLYYS LTTTQLFGAI ICCCCVIVVV VVKKEKKKEP ARVVGGRRLL EEEGQQMMLQ DDGKRRLYYS ---------- ---------- ---------- ---------- ---------- ---------- QIIIEKVDQV VNNNN----- ---------- ---------- ------MMVS DDGKRRVYYS QVVVEKTGQV VNNNN----- ---------- ---------- ------MMVS DDGQRRLYYS SLLYSTWQFY PPPPLWWKNN ----PSGLEE DVVGG----- -ASSHQVRRL GGAASYC--- SLLYSSWQFY PPPPLWWKNN ----PEGLEE EVVGG----- -AAAHQVRRL GGAASFC--- SLLYSTWQFY PPPPVAALHH ----PDGLTT AVVPP----- -YAAHQIRRL GGCCSFCVVK SLLYSTWQFY PPPPVVVMNN ----GNGLEE DVVPP----- -YAAHQIRRL GGCCSFCVV- SLLYSTWQFY PPPPRAAMNN ----ENGLTT DVVPP----- -YSSHQIRRL GGCCSFCVV- SLLYGAVQFY PPPPIWWKDD ----PNGIEE DLLPP----- -HPPHQVRRL GGCCSYC--- SLLYRAWQFY PPPPIWWKDD ----PDGMQQ DVVGG----- -QVVHQIRRL GGAASYC--- SLLYASWQFY PPPPIWWKEE ----PGGLSS DTTGG----- -LPPHQIRRL GGSSSYC--- SLLYSDWQFY ----LEEVLL DVVTVNGLKK NVVGGPLLLG PAAAHELRRY GGCCIWI--- SLLYSAWQFY ----LEEVLL DVVTANGLKK NVVGGPLLLG PAAAHELRRY GGCCIWI--- SLLYSAWQFY ----LEEVLL DVVTVKGLKK NVVGGPLLLG PAAAHELRRY GGCCIWL--- SLLYSAWQFY ----LEEVLL DVVTVKGLTT NVVGGPLLLG PAAAHELRRY GGCCIWL--- SLLYSAWQFY ----LEEVLL DVVTVKGLKK NVVGGPLLLG PAAAHELRRY GGCCIWI--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SLLYSAWQFY ----LEEVLL DVVTVKGLKK NVVGGPLLLG PAAAHELRRY GGCCIWI--- SLLYSDWQFY ----LEEVLL DVVTVKGLKK NVVGGPLLLG PAAAHEIRRY GGCCIWL--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SLLYSKWQFY ----MEEVLL DVVTEKGLKK NVVGGPGGGG PVAAHELRRY GGCCIWV--- SLLYSIWQFY ----LEEVLL DVVTKKGLKK NVVGGPDDDG PVAAHEIRRY GGCCIWI--- SLLFSAWQFY ----LKKHLL DVVTEKGLKK NVVGGPDDDG PAAAHEMRRY GGCCIWI--- SLLFSAWQFY ----LQQHLL DVVTENGLKK NVVGGPDDDG PSAAHEMRRY GGCCIWI--- SLLFSAWQFY ----LKKHII DVVTEKGLSS NVVGGPEEEG PAAAHEMRRY GGCCIWI--- SLLFSAWSFY ----IKKHII DGGTEKGLTT NVVGGPDDDG PSAAHEMRRY GGCCIWI--- SLLFSRWQFY GGGGLKKHLL DVVTEKGLSS NVVGGPEEEG PSAAHEMRRY GGCCIWI--- SLLYKKWQFY ----HSSTVV NIIPESKMEE NIIGGEGGGG PYAAHEMRRY GGCCIWI--- SLLYKKWQFY ----NSSTLL DVVPITHMVV NIIGGPGGGG PYAAHEMRRY GGCCIWI--- SFFYSTWQFY ----VEEVLL DVVTEKGLTT NVVGGPNNNG PCAAHDIRRF GGSSILA--- SLLFSPWQFY ----MAATVV DIIVENGMKK NVVGGPYYYG PGPPHEMRR- ---------- SLLYSPWQFY ----MQQHVV DVVTVNGISS NVVAAPYYYG PSPPHEMRRY GGCCIWLAA- ---------- ---------- ---------- ---------- ---------- ---------- SLLLANW--- -----KKDAA LKKYNWGKEE VVVYYGLLLG --AAHIMRRF SSLL------ SLLLANW--- -----KKDEE LKKYYWGKEE KIIYYKLLLG --PPHQMRRF RRLLPAGRRL ------- ------- R------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- VRRVVEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NSSPPSSEAA TTTPPRVVVP TRDAMQQSSL PRRTTQQSLL LTTPPIIEEA AWSSIQVLAS gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- -------GGS SALPLNNRTP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SPPPSKGRTR SVVPLLVVSS SAAVVVVPSQ QAVVVAAHWW WLPPPGKGAA VVVLGLLLPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AEERAGFF TTTLPMRRPI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MGG GLGKKEEGTT AAAQGQLLWQ ---------- ---------- ---------- -----LLKNN NSQGGCLFQQ TTTNYCTTLV ---------- ---------- ---------- ---------- ---------- ---------- TPPPPLAPSP PHHPVVPPRR LVVTTIINVP PRLLLPPPHH HARHHSLLHH IIIMVETTAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MHGVVVN ---------- ---------- ---------- ---------- ---------- ---MHAVVVS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMAA ---------- ---------- ---------- ---------- ---------- --------MS ---------- ---------- ---------- ---------- ---------- --------MP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MKRRREG-- ----ALAAAG ---------- ---------- ---------- ---------- -MKRRFISPP SSSMALVVSG ---MAIIIVF FKRRPPFFYP SSPKMAAMMM AAPPPEDDAY AACLLYYTGI IADFIAVDDS -----MMMAL LKPPPPFFYP TTPRDAAMMM AAPPPEDDAY AAALLYYVGV VPDFLAVDDS --------MM MRPPPPFFHA SSPELAAMMM AAAAAEEEAY LLLLLSSPD- -PDALAIDDS --------MM MRPPPPFFHA SSPKLAAMMM AAAAAENNAY LLLLLSSPD- -PDALAIDDS --------ML LRPPPPFFYP SSAKLAAMMM GGVVVEKKAF LLMLLSSPD- -PDGLAVDDS -----MMMAW WKPPPPFFYP SSPRLAAAAA AAPPPETTAY AAMFFDDPE- -PDAIAVDDS -----MMMVW WRPPPPFFYP SSPRMAAVVV AAAAAEKKAY VVRLLNNPMG GPDAMCVDDS -----MMMAW WRPPPPFFYP SSPKMAAMMM AARRRERRGY AALLLDDPG- -PDALGLDDS -MMTKCCCT- --CCPPYYPT PPLEAMMKKK GGRRREEEVY PPCIIYYRNT TPDYLAVDDS ---------- ---------- -------MMM GGRRREEEVY PPCIIYYRNI IPDYLAVDDS AHHTQCCCG- --CCPPYYPS PPLEAMMKKK GGRRREEEVY PPCIIYYGNI IPDYLAVDDS ---------- ---------- -----MMKKK GGRRREEEIY PPCIIYYRNI IPDYLAVDDS -MMTKCCCG- --CCPPYYST PPLEAMMKKK GGRRREEEVY PPCIIYYRNT TPDYLAVDDS STTTKCCCG- --CCPPYYST PPLEAMMKKK GGRRREEEVY PPCIIYYRNT TPDYLAVDDS -MMTKCCCG- --CCPPYYST PPLEAMMKKK GG-------- ---------T TPDYLAVDDS -MMTKCCCG- --CCPPYYST PPLEAMMKKK GGRRREEEVY PPCIIYYRNT TPDYLAVDDS DTTTKCCCG- --CCPPYYPT PPQEAMMKKK GGRRREEEVY PPCIIYYRNT TPDYLAVDDS TSSTKCCCG- --CCPPYYST PPLEAMMKKK GGRRREEEVY PPCIIYYRNT TPDYLAVDDS -MMTKCCCG- --CCPPYYST PPLEAMMKKK GGRRREEEVY PPCIIYYRNT TPDYLAVDDS ANNKTCCCCT TAKKPPYYAT PPLEAMMEEE GGRRREKKVY TTCVVYYNGI ILDYLAVDDS ---------- ---------- ---------- ---------- ---------- ---------- ---AKCCCG- --CCPPYYKS PPLDAMMKKK GGRRREEEVY PPCIIYYRSI IPDYLAVDDS KKK-VNNNGC CKSSPPYYAS PPIESMMSSS GGRRRESSIY TTAVVYYAGI IPDYLAVDDS KVVNQQQQGC CKSSPPYYAS PPLEAMMSSS GGRRRETTIY TTAVVYYAGI IPDYLAVDDS ---------- ---------- ---------- ---------- ---------- ---------- -----RRRMQ QVGGPPYYAT PPLAAMMSSS GGSSSEKKIY TTAVVYYTGI IPDYLAVDDS ANNAACCCCG GATTPPYYAT PPLEAMMEEE GGRRREKKLY TTCVVYYNGI IPDYLGVDDS NCCLKCCCH- ----PPYYAS PPADAIIKKK GGRRREEELF TTAPP----A APDAIFVDDS -CCLKCCCH- ----PPYYAS PPADAIIKKK GGRRREEELF TTAPP----R RPDAIFVNNS ---------- ---------- ---------- ---------- ---------- ---------- ---MSEEESC CKCCPPYYAT PPLDAVVRRR GGVVVEKKLY VVCVVQQPNE EGDYLAVDDS ---------- ---------- -----MMRRR GGRRREKKLY VVTVVQQPNE EGDYLSVDDS ---------- ----PPLLIT ---DILLIII LLDDDRFFYF NNWLLHHGDQ QITDRKPRRV ALLMGLLLPR RAFFDDTTCQ SSPYMPPKKK TTQQQEEEVY WWTLLGGVEG GQDKLVIDDS ALLLAAAAPG GVRRDDTTCA SSPYMKKKKK TTQQQEDDVY WWTLLGGAEG GQDKLVVDDS TYYKKIVHEY YIINEEEHHF NNACCSSSSA LCCCC-PPPP GGPPNNIERR RRFFLLIIVV TYYKKVIYDY YIIGEEEHHF NNACCSSSSA YCCCC-PPPP AAPPFFLERR RRYYLLIIVV TYYKKIVHTN NTTGEEEHHF NNACCSSSSS LSSSS-PPPP TTAAFFLERR RRFFLLIIII TYYQQIVHTN NKKGEEEHHF NNACCSSSSA LSSSS-PPPP AAAAFFIERR RRYYLLIIII KFFQQIVHIN NKKGEEEHHF NNACCSSSSA LSSSS-PPPP TTAAFFLERR RRYYLLIIII RYYSSIVGAH HAAGEEEHHF NNACCSSSSC LCCCC-PPPP AAPPHHMERR RRYYLLVVVV TFFQQVVGDY YTTGEEEHHF NNACCSSSSM LCCCC-PPPP AAPPHHVERR RRYYLLVVVV TYYQQIVGEN NAAAEEEHHF NNACCSSAAA LCCCC-PPPP AAPPHHVERR RRYYLLIIVV QYYQQVIHPY YLLKEEEHHS NNTCCSSSSC ---------- FFSSTTKSRR NNKKLLIILL HYYQQVIHPH HLLKEEEHHS NNTCCSSSSC ---------- FFSSTTKSRR DDKKLLIILL QYYQQVIHPN NLLREEEHHS NNACCSSSSC ---------- FFSSTTKSRR TTKKLLMMLL QYYQQVIHPH HLLKEEEHHS NNTCCSSSSC ---------- YYIITTKARR TTKKLLVVLL QYYQQVIHPN NLLKEEEHHS NNTCCSSSSC ---------- FFSSTTKSRR TTKKLLVVLL QYYQQVIE-- ---------- ---------- ---------- ---------- ---------- QYYQQVIHPN NLLKEEEHHS NNTCCSSSSC ---------- FFSSTTKSRR TTKKLLVVLL QYYQQVIHPN NLLKEEEHHS NNTCCSSSSC ---------- FFSSTTKSRR TTKKLLVVLL QYYQQVIHPY YLLKEEEHHS NNTCCSSSSC ---------- FFSSTTKSRR NNKKLLVVLL QYYQQVIHPN NLLKEEEHHS NNTCCSSSSC ---------- FFSSTTKSRR TTKKLLVVLL QYYQQVIHPN NLLKEEEHHS NNTCCSSSSC ---------- FFSSTTKSRR TTKKLLVVLL TYYQQVIHPH HIIGKKKHHS NNSCCSSSSC ---------- HHPPSSAKRR RRFFLLIILL ---------N NTTNEEEHHS NNTCCSSSSC ---------- YYAASSKVRR NNKKLLIILL SYYQQVIHPN NVVNEEEHHS NNTCCSSSSC ---------- YYSSSSKVRR NNKKLLIILL TYYKKVIHPY YVVGEEEHHT NNSCCSSSSC ---------- HHPPSSAERR RRFFLLIIAA TYYKKVIHPY YVVGEEEHHT NNSCCSSSSC ---------- HHPPSSAQRR RRFFLLIIVV ---------F FVVGEEEHHS NNSCCSSSSC ---------- HHAASSADRR RRYYLLVVLL SYYSSVIHPF FVVGEEEHHS NNSCCSSSSC ---------- HHAASSVDRR RRYYLLVVLL TYYQQVIHPH HVVGEEEHHS NNACCSSSSC ---------- HHPPSSASRR RRFFLLIILL TFFQQVISDH HIIGEEEHHT NNACCSSSSC ---------- HHPPTTEKRR SSHHLLIIVV TFFQQIISDN NIIGEEEHHT NNACCSSSSC ---------- HHPPTTEKRR SSHHLLIIVV ---------- ---------- ---------- ---------- ---------- ----MMVVPP TYYQQVIHYS SKKHEEEHHS NNTCCSSSSC HFFFFVPPPP GGEEVVPTRR DDRRLLVVLL TYYQQIVHFR RKKGEEEHHS NNACCSSSSC YYYYYVDDDD SSTTVVPKRR DDRRLLVVLL LGGSSVLKPV VLLEKKKLDS TTPRRIILLK ---------- --RRVVQGGG PPQQMMLLQQ TRRQQVINSG G--REEEHHG SSA------- ---------- -------DRR RRFFFFWWTT QYYKKVVNSG G--REEEHHS TTD------- ---------- -------DRR RRYYLLWWAA GLSRRIYYID DDDPPREKII KKVVVIEEPE VSGSTVVCGP DAIIYAAGGG EE--EEGEEG ALSRRIYYID DDDPPRRAVA KKIIIVEEPE RTGTTVVCGP DAIIYAAGGG PP--DDGEEG GLSRRIYYVD DDDPPTQRIH KKIIIIEEPD KTGSTVVCGP EGIIYTTGGG AAKKDDGDDP GLSRRIYYID DDDPPTKKIH KKIIIIEEPE KTGSTIICGP DGIIYTTGGG GGKKDDGNNP GISRRIYYID DDD--LKKIH KKIIIIEEPE KTGSTIICGP EGIIYTTGGG GGEEDDGDDP GLSRRIYYID DDDPPLKFLA KKVVVIEEPE RTGSTVVCGP GGIIYAAGGG AA--EEGKKG DISHHITTID DDDPPTQKVV KKVVVIDDPN RTGATVVCGP DGIIYAAGGG PP--EEGEEG GISRRIHHID DDDPPRERIV KKVVVIEEPE RTGSTIICGP DGVVYAAGGG PP--EEGDDG GLSRRIYYVD DDDSSRAKLH KKVVVIEEAS KCNSTSSCLA SGEEVNNLLL DD--LLQNNG SISRRIYYVD DDDSSRAKLH KKVVVIEEPN KCNGTSSCLA SGEEVSSLLL DD--PPQNNG CLSRRIYYVD DDDSSRAKLH KKVVVIEEAE KCGGTSSCLA SGEEVSSLLL DD--SSKNNG ALSRRIYYVD DDDTTRAKLH KKVVVIEEPK KCNGTSSCLP SGEEVSSLLL DD--PPENNG SLSRRIYYVD DDDSSRAKLH KKVVVIEEPE KCEATSSCLA SGEEVSSLLL DD--VVKNNG ---------- ---------- --------PK KCEATSSCLA SGEEVSSLLL DD--VVKNNG SLSRRIYYVD DDDSSRAKLH KKVVVIEEPK KCEATSSCLA SGEEVSSLLL DD--VVKNNG SLSRRIYYVD DDDSSRAKLH KKVVVIEEPK KCEATSSCLA SGEEVSSLLL DD--VVKNNG SFSRRIYYVD DDDTTRAKLH KKVVVIEEAK KCGGTSSCLP TGEEVSSLLL DD--PPKNNG SL-------- ---------- ---------- ---------- ---------- ---------- SLSRRIYYVD DDDSSRAKLH KKVVVIEEPK KCEATSSCLA SGEEVSSLLL DD--VVKNND SLSRRVYYVD DDDTTRTSLH KKVVVVEESE NIGGTSSCLA SGDDISSLLL DD--KKENNG CLSRRIYYVD DDDTTRARIH KKTTTVEEPY KCGATSSCLG CGEEISSIII DD--PPYNNG CLSRRIYYVD DDDSSRARIH KKTTTVEEPY KCGATSSCLG CGEEISSLLL DD--PPCNNG SLSRRIYYVD DDDTTRSSLH KKVVVVDDPA KTGATSSCLA SGEELSSLLL DD--KKDNNG GISRRVYYVD DDDTTRASLH KKVVVVEEPE KTGATSSCLA SGEEISSIII DD--KKDNNG SLSRRIYYAD DDDEERASLY KKYYYVDDPK KTGATAACLA SGEEISSLLL DD--EEENNG SLSRRIYYAD DDDEERASLY KKYYYVDDPK KTGATAACRT -GEEISSLLL DD--EEENNG SLSRRVYYVD DDDKKRAALH KKVVVVEEAE KTGGTSSCLA SGEEISSLLL DD--KKENNG CLSRRIYYIN NNNNNRKYLE HHTTTIEEPS LN-STSSCLA DGNNISSLLL EE--AANTTG CLSRRIYYVN NNNNNREYLQ HHTTTIEEPS LN-STSSCLA DGNNISSLLL EE--AADSSG KLSVVEGGKF FFFGG----- ---------- ---------- ---------- ---------- CLSRRIFFVD DDDTTRAKLA KKVVVIEEG- GADTTTTCLP NGNNISSMMM DD--AAENNG SLSFFIYYID DDDTTRKEIV KKTTTIDDG- SHNTTTTCLA NGNNISSMMM DD--AAEYYG SLGRRLYYVT TTTYYWDQFY PP-------- FLVATAAYQP NTAALDDVVV EE--SSLVVL GLTRRIFFID DDDSSSNKLH KKTTTIDDT- SGGVTFFALP GSMMMGGSSS DD--DDDGGT GLTKKIFFVD DDDSSARVLS KKTTTITTD- SGGVTLLALP GRMMLGGSSS NN--KKDGGT LLHYYYYYSF FFPPWDDGGD Y--------- ----AFLLL- -PPNNEEVSS EWWWAAAV-- LLHDDDDDTF FFPPWYYGGP Y--------- ----AFLLL- -PPSSGGVSS EWWWTTTV-- MMCEEEEETF FFVVWDDGGP D--------- ----HFLLL- -PPRRDDYSS EWWWAAAL-- MMCEEEEETF FFVVWDDGGP T--------- ----HFLLL- -PPRRDDYSS EWWWAAAL-- LLCEEEEETF FFIIYDDGGE T--------- ----HFLLL- -PPRRDDYSS EWWWGGGL-- LLAQQQQQSF FFPPWEEGGP Y--------- ----AGLLL- -GGYYDDTSS EWWWGGGT-- LLHDDDDDNL LLVVWDDGGD Y--------- ----HFLLL- -GGYYDDTSS EWWWGGGT-- MMHEEEEESF FFPPWEEGGP Q--------- ----AFLLL- -GGYYDDTSS EWWWGGGT-- LLGEEEEETF FFVVWPPGGA P--------- ----GFPPP- -RRHHNNVTT EWWWAAAA-- LLGEEEEETF FFVVWPPGGE P--------- ----GFPPP- -RRHHNNITT EWWWAAAA-- LLGEEEEETF FFVVWPPGGA P--------- ----GFPPP- -RRHHNNVTT EWWWAAAA-- LLGKKKKKTF FFVVWPPGGA P--------- ----GFPPP- -RRHHNNVTT EWWWAAAA-- LLGEEEEETF FFVVWPPGGA P--------- ----GFPPP- -RRHHNNVTT EWWWAAAA-- LLGEEEEETF FFVVWPPGGA P--------- ----GFPPP- -RRHHNNVTT EWWWAAAA-- LLGEEEEETF FFVVWPPGGA P--------- ----GFPPP- -RRHHNNVTT EWWWAAAA-- LLGEEEEETF FFVVWPPGGA P--------- ----GFPPP- -RRHHNNVTT EWWWAAAA-- LLGEEEEETF FFVVWPPGGS P--------- ----GFPPP- -RRHHNNVTT EWWWAAAA-- ---------- ---------- ---------- ---------- ---------- ---------- LLP-----RL LLCC------ ---------- ---------- --------AA ISSSAAAH-- LLDSSSSSEF FFVVGRRFFP S--------- ----EHNNNY YAAWWGGLWW IQQQCCCC-- LLGEEEEETF FFVVWEEEEA P--------- ----GFPPP- -RRHHNNVTT EWWWGGGA-- LLGEEEEETF FFVVWEEEES Q--------- ----GFPPP- -RRHHNNVTT EWWWGGGA-- LLDSSSSSDF FFVVWPPHHS L--------- ----GFPPP- -RRHHNNTTT SWWWGGGA-- LLDSSSSSEF FFVVWPPHHS L--------- ----GFPPP- -RRHHNNTTT SWWWGGGA-- LLDSSSSSDF FFIIWPPHHS L--------- ----GFPPP- -RRHHKKTTT SWWWGGGA-- LLDSSSSSDF FFIIWPPIIS L--------- ----GFPPP- -RRHHKKTTT SWWWGGGA-- LLDSSSSSEF FFVVWPPHHS L--------- ----GYPPP- -RRHHKKTSS SWWWGGGA-- LLGKKKKKTF FFPPWDDKKT P--------- ----NFPPP- -RRRRNNVTT EWWWGGGS-- LLGKKKKKTF FFPPWDDKKV P--------- ----NFPPP- -RRRRNNITT EWWWGGGS-- ---------- ---------- ---------- ---------- --------II LRRRGGGG-- EEDKKKKKNF FFLLWGGRRK L--------- ----GYPPP- -HHFFNNVSS EWWWGGGA-- LLDSSSSSDF FFCCWGGKKK L--------- ----GFPPP- -YYFFDDVSS EWWWGGGA-- TTKHHHHHEN NNLLGSSFFE I--------- ----QNGGG- ---RREEKDD RPPPDDDE-- YYDDDDDDGE EEVVWTTDDD QGGAAVVVGG DAAAGIIII- -RRKKNNVSS SFFFTTTGNY YYNAAAAAGE EEVVWTTGGD RGGAATTTGG -KKKDVPPP- -RRKKNNLSS SFFFTTTGNY TTIEEEDDDD GGLLLLDDD- RRGRRIWLKR RRISSSTTGG EEEEENRRMM ----EEELRR CCFEEEEEEE GGLLLLEEEG AAGKKLWLKR RHLAAADDGG QQEEEHRRMM ----EEEVRR QQFEEENNNN GGPPPPAAAN KKGRRLWLAR RNVTTTDDGG AAQQQHQQMM ----EEEVRR QQFEEENNNN GGPPPPSSSN KKGRRLWLAR RNVTTTDDGG AANNNHQQMM ----EEEVRR QQFEEENNNN GGPPPPSSSN KKGKKIWLDR RNVTTTDDGG AANNNHQQMM ----EEEIRR MMVEEEDDDD GGPPPPGGGA RRGRRLWLRR RHLEEEDDGG DDEEEHQQLL ----EEELRR MMVEEESSSS GGGGGGAAAG KKGRRLWLRR RHLTTTDDGG AAEEEYQQMM ----EEELRR MMIEEEGGGG GGPPPPNNNK GGGRRLWLRR RHLAAADDGG EEEEEHQQMM ----EEELRR VVFKKKDDDD GGAAAA---G LLGRRIWWRH HIITTTQQTT -----DGGLL --LLEEEIRR VVFKKKDDDD GGAAAA---G LLGHHIWWRH HIITTTQQKK -----DGGLL --LLEEEIRR VVFRRRDDDD GGAAAA---G LLGHHLWWRH HIITTTTTQQ -----DGGLL --LLEEEIRR VVLRRRDDDD GGAAAA---G LLGHHLWWRR RIVTTTPPQQ -----DGGLL --LLEEEIRR VVLRRRDDDD GGAAAA---G LLGHHLWWHH HIVTTTSSKK -----DGGLL --LLEEEIRR VVLRRRDDDD GGAAAA---G LLGHHLWWRH HIVTTTSSKK -----DGGLL --LLEEEIRR VVLRRRDDDD GGAAAA---G LLGHHLWWRH HIVTTTSSKK -----DGGLL --LLEEEIRR VVLRRRDDDD GGAAAA---G LLGHHLWWRH HIVTTTSSKK -----DGGLL --LLEEEIRR VVVQQQNNNN GGAAAA---G LLGHHLWWRH HIVTTTLLPP -----DGGHH --LLEEEIRR ---------- ---------- ---------- ---------- ---------- ---------- LLRLLLTTTT GGYYYY---S RRAIIT---- ---------- ---------- ---------- FFYTTTTTTT GGMMMM---S GGHIISDYMR RIDSSSPPQQ -----DQQAA PPLLCCCLRR AAFAAALLLL GGEEEE---G MMGSSLWWEH HRITTTDDGG EE---DGGLL --LLEEEIRR AAFAAALLLL GGEEEE---G HHGSSLWWEH HLVTTTDDGG KK---DGGLL --LLEEEIRR AAFTTTKKKK GGQQQQ---G LLGHHLILRG GLRTTTDDGG NN---TGGLL --LLEEEIRR AAFLLLQQQQ GGQQQQ---G LLGHHLYWGG GIKTTTDDGG DD---KGGLL --LLEEEIRR AAFSSSKKKK GGQQQQ---G LLGHHLYWGG GMKLLLDDGG EE---TGGLL --LLEEEIRR AAFSSSKKKK GGQQQQ---G LLGHHLYWGG GIKLLLDDGG PP---TGGLL --LLEEEIRR AAFRRRTTTT GGQQQQ---G LLGHHLYWGG GLKTTTDDGG SS---TGGLL --LLEEEVRR HHIKKKKKKK GGAAAA---G LLGSSVFWSK KYLTTTDDPP QQPPPLGGAA --LLEEEVRR HHIKKKKKKK GGAAAA---G LLGSSVFWTK KHLTTTDDPP MMPPPRGGAA --LLEEEVRR TTVCCCRRRR DDKKKK---P LLICCKY--- ---------- ---------- ---------- LLFRRRRRRR GGTTTTRRRT QQGRRLYWER RLFTTTDDGG DD---DGGLL --LLEEEIRR KKWRRRRRRR GGVVVVMMMS QQGRRLYWTQ QLYTTTDDGG SS---DGGII --LLEEEIRR MMAFFFEEEE SSFFFFGGGP LLPHHVV--- ---------- ---------- ---------- MMMDDDFFFF GGQQQQMMMK RRGTTIWLTR RPKVVVNNPP GGAAAP---- --LLEEEIRR MMMDDDFFFF GGAAAAMMMK HHGTTVWLTK KPKVVVDDPP GGAAAP---- --LLEEEIRR RLHLLMGFFM MVSSKKDLSS SSIIWWWEDD GWNNAAAEAP PEG--LPPEE EEIPPKKKKA RLHLLMGFFV VVNNKKDLSS SSIIWWWEDD GWQQAAADAP PEG--LPPPP PPVDDKKKKM RAHEEYGFFV VVDDTTNLEG SSIIWWWEGG GFHHVVVTAP PTADDLPPPP PPLGGGGGGA RAHEEYGFFV VVDDTTNLEA SSIIWWWEGG GFHHAAATPP PPKEELPPPP PPLGGGGGGA RAHDDYGFFV VVDDTTNLQG AAIIFFWDDD GFEEAAATPP PDADDLPPDD DDLGGGGGGA RAHAAYGFFC CVSSKKDLSS SSIIWWWDKK DWAAVVVEAA ADPDDLPPPP PPVGGKKKKA RAHAAYGFFC CVSSKKDLSA SSIIWWWDNN GWHHLLLDAP PSEDDLPPPP PPIPPKKKKA RAHTTYGFFV VVSSEEDLSA SSVVWWWQNN GWGGIIIEAP PEPDDLPPPP PPLDDGGGGA RLHTTQGFFC CASSNNIQRF YYKKNNE--- -------WEV VQVPPKKKVV VVKMMPPPPE RLHTTQGFFC CASSNNIQRF YYKKNNG--- -------WEV VQVPPKKKVV VVKMMPPPPE RLHAAQGFFC CASSTTIQRF YYKKNNG--- -------WEV VQVPPKKKVV VVKMMPPPPE RLHAAQGFFC CASSTTIQRF FFKKNND--- -------WQV VQVPPKKKVV VVKMMPPPPE RLHAAQGFFC CASSTTIQRF YYKKNNG--- -------WEV VQVPPKKKVV VVKLLPPPPE RLHAAQGFFC CASSTTIQRF YYKKNNG--- -------WEV VQVPPKKKVV VVKLLPPPPE RLHAAQGFFC CASSTTIQRF YYKKNNG--- -------WEV VQVPPKKKVV VVKLLPPPPE RLHAAQGFFC CASSTTIQRF YYKKNNG--- -------WEV VQVPPKKKVV VVKLLPPPPE RLHSSQGFFC CASSTTIQRF YYKKNNG--- -------WEV VEVPPKKKVV VVKMMPPPPE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RIHNNQDYYV VESSSSGRGG SSDDPPA--- -------VKK KDLYYAVVVV VVAGGVVVVS RLHAAQGLLC CASSTTVFRF YYKKEED--- -------WEV VKVPPKKKVV VVEAAPPPPE RLHDDQGLLC CASSSSIFRF YYKKEED--- -------WEV VQVPPKKKVV VVEPPPPPPE RLHDDTGFFS SASSNNMIRF FFKKTTD--- -------WEA APVKKLKKVV VVQIIPPPPE RLHDDTGFFS SATTNNMIRF FFKKTTD--- -------WEV VSVEELKKVV VVQFFPPPPE RLHDDTGYYS SASSNNMIRF FFKKNND--- -------WEV VSVKKLKKVV VVEIIPPPPE RLHDDTGFFS SASSNNMIRF FFKKNND--- -------WEV VSVKKLKKVV VVEIIPPPPE RLHDDTGYYC CATTNNMVRF FFKKTTD--- -------WEA ASIKKLKKVV VVRIIPPPPE RLHEEHAFFC CAGGGGIFRI HHPPVVE--- -------HTV VFIPPKKKVV VVSAAPPPPE RLHEEHAFFC CAGGAAIFRI HHPPDDK--- -------QSV VTIPPKKKVV VVEAAPPPPD ---------- ---------- ---------- ---------- ---------- ---------- RLHNNQGYYC CAXXXXXXXX XX-------- ---------- ------QQGG GGEEEEEEEM RLHAAEGFFC CANNKKVFHF KKKKKKD--- -------AVD DPGKKVDDTT TTGVVEEEED ---------- ---------- ---------- ---------- ---------- ---------- RPWNNYAFFT TATTQQLWLI YYEEDDA--- ---------- -EWQQKAAVV VVAGGPPPPA RAWNNYCFFT TATTQQLWLI YYEEDDE--- ---------- -EWQQKAAVV VVAGGPPPPA AVVVPPLLVT TIDISDDKKF LSSWWGGEVV RRQYDIISSP FKVVVVTGKG GGGGIHRRHP MVVVPPLLVT TIDISDDRRF VSSWWGGELL RRQYDIITTP HQRRRRAGKG GGGGLHRRHP AVVVPPLLVT TIDLSDDRRF VSSWWGGEMM RRQYDVVSSP HNVVVVAGRG GGGGIRRRHP AVVVPPLLVT TIDLSDDRRF VSSWWGGEMM RRQYDVVSSP RKKKKKAGHG GGGGIRRRHP ACCCPPLLVT TIDLSDDKKY VAAWWGGEMM HHQYDVVSSP MNVVVVTGEG GGGGIKKKHP AVVVPPLLVT TIDLSDDRRF VSSWWGGDLL LLQYDVVSSP FEKKKKTGRG GGGGISRRHP AVVVPPLLVT TINLSDDRRF VSSWWGGELL HHQYDVVSSP FNRRRRTGQG GGGGIRRRHP AVVVPPLLVT TINLSDDRRF VSSWWGGELL RRQYDVVSSP FNRRRRTGRG GGGGIRKKHP EMMMPGLLIT TILLSDDRRF FSSWWLGDII RRQYDIISSP QKRRRRTGFG GGGGSVRRSV EMMMPGLLIT TILLSDDRRF FSSWWLGDII RRQYDIISSP KKRRRRTGFG GGGGSVKKSV EMMMPGLLIT TILLSDDRRF FSSWWLGDLL RRQYDIISSP QRRRRRTGFG GGGGSVKKPV EMMMPGLLIT TILLSDDHHF FSSWWLGDII RRQYDVVSSP QRRRRRTGFG GGGGSVKKPV EMMMPGLLIT TILLSDDRRF FSSWWLGDLL RRQYDIISSP QRRRRRTGFG GGGGSVKKPV EMMMPGLLIT TILLSDDRRF FSSWWLGDLL RRQYDIISSP QRRRRR---- ---------- EMMMPGLLIT T--------- ---------- ---------- ---------- ---------- EMMMPGLLIT TILLSDDRRF FSSWWLGDLL RRQYDIISSP QRRRRRTGFG GGGGSVKKPV EMMMPGLLIT TILLSDDRRF FNNWWLGDMM RRQYDIISSP KRRRRRVGFG GGGGSVKKPV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SLLLSNEEFP PAWIFSDLLL FLL------- ---------- ---------- ---------- EMMMPGLLIT TILISDDRRF FSSWWLGDII RRQYDIITTP RNKKKKVGFG GGGGSLRRPV EMMMPGLLIT TILISDDRRF FSSWWLGDII RRQYDIITTT RNKKKKVGFG GGGGSQRRPV EMMMPGLLIT TFLISDDRRF FVVWWLGDII RRQYNIIEEL KNVVVVTGWG GGGGLQKKPV EMMMPGLLIT TFLISDDRRF FVVWWLGDII RRQYNIIEEV KNKKKKTGWG GGGGLQKKPV EMMMPGLLIT TFLISDDRRF FVVWWLGDII RRQYNIIEEP KNVVVVTGWG GGGGLQKKPV EMMMPGLLIT TFLISDDRRF FVVWWLGDII RRQYNIIEEP KNVVVVTGWG GGGGLQKKPV EMMMPGLLIT TFVISDDRRY LVVWWLGDII RRQYNIIEEP AKVVVVAGWG GGGGLQKKEV EMMMPALLIT TILISDDRRF VSSWWLGDII RRQYDIISSP LKKKKKNSYG GGGGSHTTNV DMMMPALLIT TILISDDRRF VSSWWLGDII RRQYDIISSP KNKKKKNSFG GGGGSHSSTV ---------- ---------- ---------- ---------- ---------- ---------- MMMMGGMMMT TILISDDRRY FSSWWRGDVV RRQYDIISSR ANRRRRTGFG GGGGAQRRPR DMMMGGMMIS SIIISDDRRF VNNWWRGDVV RRQYDIITTP ENKKKKTGFG GGGGACSSPN ---------- ---------- ---------- ---------- ---------- ---------- ADDDIPLLPV VISIADDQQT INNFFMGKTT RRLFDIISSP HKFFFFIYVD DDRRQN---- AKKKVPLLPV VISISDDSSR VNNFFMGKTT RRLFDIISSP HHRRRRVYTG GGAAQN---- ---------- ---------- AAGGHHLTGA MLISRRRRGR VVVNLLLLYT TTTNYGGKKG ---------- ---------- SSGGAAATGA MIVSRRRRGR VIINLLLLYS SSSNYGGRRG ---------- ---------- NNGGRRFAGG MVISRRRRGR VWWNLLLLYT TTTDYGGPPA ---------- ---------- NNGGKKFAAG MVISRRRRGR VWWNLLLLYT TTTDYGGPPG ---------- ---------- NNGGKKFGYG MVISRRRRGR VWWNLLLLYT TTTEYDDGGA G--------- ---------- KKNNGGLNGG MVISRRRRGR VFFNLLLLYA AAAPYGGDDG ---------- ---------- TTSSAALNGG MVISRRRRGR VFFNLLLLYA AAAEYGGKKG ---------- ---------- AASSGGLNGG MVVSRRRRGR VFFNLLLLYS SSSEYGGRRG QVVLEEE-DT TCCCCQPEEL KKGGKKIPGG MILSLLLLGR LAATLLLLYD DDDKYDDIIR QVVLEEE-DT TCCCCQPEEL KKGGKKVPGG MILSLLLLGR LVVTLLLLYA AAAKYNNIIR QVVLEEE-DK KSSSSQPEEL KKGGKKVPGG MILSLLLLGR LVVTLLLLYA AAAKYDDIIR QVVLDDD-DD DSSSSQPEEL KKGGKKVAGG MILSLLLLGR LVVTLLLLYA AAAKYDDIIR QVVLEEE-DK KSSSSQPEEL KKGGKKVAGG MILSLLLLGR LIITLLLLYA AAAKYDDIIR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QVVLEEE-DK KSSSSQPEEL KKGGKKVAGG MILSLLLLGR LIITLLLLYA AAAKYDDIIR QVVLEEE-DK KSSSSQPEEL KKGGKKVPGG MILSLLLLGR IVVTLLLLYD DDDKYDDIIR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TVVLEEE-DE ECCCCQPDDV KKGGKKVPGG MILSLLLLGR LVVNLLLLYK KKKKYDDIIK TVVLEEE-DE ECCCCQPDDV KKGGKKIPGG MILSLLLLGR IVVSLLLLYI IIIKYDDLLK AAAIGGG-ET TWWWWQSDDP QQGGQQLRGG MILTLLLLGR LVVNLLLLFA AAAKYGGVVE VAAVKKK-DT TWWWWQSDDP QQGGKKLRGG MILSLLLLGR LVVNLLLLFA AAAKYKKVVE KAAVGGG-ES SFFFFQFDDP KKGGKKLRGG MILSLLLLGR LAANLLLLFA AAARYEEMMD KAAVGGG-ET TFFFFQFEEP KKGGKKLRGG MILSLLLLGR LAANLLLLFA AAAVYEEMME VYYVTTT-EE EEEEEQYSSP KKGGHHLRGG MILSLLLLGR IVVNLLLLFR RRREYDDVVK KVVLEEE-G- -----PIEEL KKGGRRIEGG MLLSLLLLGR LVVTLLLLYK KKKDYEEVVK KVVLEEE-E- -----EIPPL KKGGRRIEGG MLLSLLLLGR LVVTLLLLYK KKKDYEEVVR ---------- ---------- --------GG KILSVVVVGR LVVNFFFFYT TTTKYNNVVK RVVLNNN-DK KEEEEAPEEV KKGGRRLLGG MLLSLLLLGR LVVSLLLLFP PPPKYEEVVA VIIVKKKEDK KEEEERPPPR KKGGRRLEGG MLLSLLLLGR LVVSLLLLYP PPPKYKKVVS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MVQSWWWWGR VFFSLLLLLN NNN------K ---------- ---------- ---------- MVSSWWWWGR LYYSLLLLLN NNN------K MLLNNAN--- --PPPGGIII EFFFGEE--- ----QVRRRL LSGGGSSYYY YYYCYP---- MVVNNVN--- --PPPGGLLL EFFFGRR--- ----QVRRRL LWGGGSSFFF FFFCYP---- QAAHHAG--- --PPPGGLLL DWWWPDD--- ----QIRRRL LEGGGSSFFF FFFCYPSR-- EAANNVG--- --GGGGGLLL DFFFPDD--- ----QIRRRL LEGGGSSFFF FFFCYPS--- MAANNVG--- --EEEGGLLL DWWWPAA--- ----QIRRRL LEGGGSSFFF FFFCYPS--- MLLDDAG--- --PPPGGFFF KFFFPKK--- ----QVRRRL LQGGGSSYYY YYYCYP---- MVVDDVN--- --PPPGGFFF NFFFGEE--- ----QIRRRL LQGGGSSYYY YYYCFP---- IAAEEAD--- --PPPGGLLL GFFFGDD--- ----QIRRRL LEGGGSSYYY YYYCYPS--- GMMLLQVDVV DDVVVGGLLL NLLLGKKPLG GGPPELRRRY YPGGGIIWWW WWWI------ GMMLLQIDVV DDAAAGGLLL NLLLGKKPLG GGPPELRRRY YPGGGIIWWW WWWI------ GMMLLQIDVV DDVVVGGLLL NLLLGKKPLG GGPPELRRRY YPGGGIIWWW WWWL------ GMMLLQIDVV DDVVVGGLLL NLLLGKKPLG GGPPELRRRY YPGGGIIWWW WWWL------ GMMLLQVDVV DDVVVGGLLL NLLLGKKPLG GGPPELRRRY YPGGGIIWWW WWWI------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GMMLLQVDVV DDVVVGGLLL NLLLGKKPLG GGPPELRRRY YPGGGIIWWW WWWI------ GMMLLQIDVV DDVVVGGLLL NLLLGKKPLG GGPPEIRRRY YPGGGIIWWW WWWL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GMMLLQIDVV DDEEEGGLLL NLLLGKKPGG GGPPELRRRY YPGGGIIWWW WWWV------ GMMLLQIDVV DDKKKGGLLL NLLLGKKPDG GGPPEIRRRY YPGGGIIWWW WWWI------ GIILLQIDVV DDEEEGGIII NFFFGAAPDG GGPPEMRRRY YPGGGIIWWW WWWI------ GIILLQIDVV DDEEEGGIII NFFFGAAPDG GGPPEMRRRY YPGGGIIWWW WWWI------ GIIIIQIDVV DDEEEGGIII NFFFGDDPEG GGPPEMRRRY YPGGGIIWWW WWWI------ GIIIIQIDGG DDEEEGGIII DFFFGDDPDG GGPPEMRRRY YPGGGIIWWW WWWI------ GMMLLQIDVV DDEEEGGIII NFFFGAAPEG GGPPEMRRRY YPGGGIIWWW WWWI------ GMMVVQVNII DDEEEGKIII DLLLGKKEGG GGPPEMRRRY YPGGGIIWWW WWWI------ GMMLLQIDVV DDIIIGHIII NLLLGKKPGG GGPPEMRRRY YPGGGIIWWW WWWI------ GMMLLQIDVV DDEEEGGVVV NLLLGKKPNG GGPPDIRRRF FPCGGIILLL LLLA------ GIIVVQLDII DDEEEGGLLL NLLLGGGPYG GGPPEMRRR- ---------- ---------- GIIVVLIDVV DDVVVGGLLL DLLLANNPYG GGPPEMRRRY YPGGGIIWWW WWWLAND--- ---------- ---------- ---------- ---------- ---------- ---------- GDDAAQYLKK AANNNDGLLL DAAAYEEGLG GG--IMRRRF FGSSS----- ---------- GDDEEQFLKK LLYYYDGLLL QAAAYAAKLG GG--QMRRRF FGARRPPAAA AAAGDGNVQQ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- RRRVVVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNKKKQQSEE ATTRTPPPTT LTAAAARLAA DDDAQQQSLP RRTTAAQLLL SLLPPGPPKA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QAATTFIQQQ LLASPRSSEE KRRRKKTRSS SVPGLIISSA AAAVVQAAAQ WWAAHHWLGK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------RA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMGLEE ---------- ---------- ---------- ---------- ---------- LLLLKKNSCL ---------- ---------- ---------- ---------- ---------- ---------- ARRPPTLNNN RRTPPHPPNN LPPPAASPPP PHPRVTTLLV VPPTIPPPRP CCPPPPHASL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MRE ---------- ---------- ---------- ---------- ---------- -------MFI ---------- -AVVFKKRRD PFPPPAAAMP EDDLAAAYVV VAACYTTGIN RDDVVDDVPP ---------- --AALKKPPD PFPPPAAAMP EDDIAAAYVV VAAAYVTGVN ADDVVDDVPP ---------- --MMMRRPPD PFAAPAAAMP EEEFAAAYTT TLLLSPFS-- RDDVVDDVPP ---------- --MMMRRPPD PFAAPAAAMP ENNFAAAYTT TLLLSPFS-- KDDVVDDVPP ---------- --MMLRRPPD PFPPAAAAMP EKKLAAAFTT TLLMSPAS-- KDDVVDDVPP ---------- --AAWKKPPD PFPPPAAAAP ETTIAAAYVV VAAMDPRK-- QDDVVDDVPP ---------- --VVWRRPPD PFPPPAAAVP EKKLAAAYVV VVVRNPANG- KDDVVDDVSS ---------- --AAWRRPPD PFPPPAAAMP ERRLGGGYVV VAALDPRE-- RDDVVDDLPP ---------- -KTT---CCG PYTTLMMMKP EEEIVVVYLL LPPCYRTGTE ADDTTDDVPP ---------- ---------- --------MP EEEIVVVYLL LPPCYRTGIE ADDTTDDVPP HVVVPLLLPG AQGG---CCG PYSSLMMMKP EEEIVVVYLL LPPCYGTGIE ADDTTDDIPP ---------- ---------- -----MMMKP EEEIIIIYLL LPPCYRTGIE ADDTTDDVPP ---------- -KGG---CCG PYTTLMMMKP EEEIVVVYLL LPPCYRTGTE ADDTTDDVPP ETTTVMMRPI SKGG---CCG PYTTLMMMKP EEEIVVVYLL LPPCYRTGTE ADDTTDDVPP ---------- -KGG---CCG PYTTLMMMK- ---------- --------TE ADDTTDDVPP ---------- -KGG---CCG PYTTLMMMKP EEEIVVVYLL LPPCYRTGTE ADDTTDDVPP PAAAFQQLWQ DKGG---CCG PYTTQMMMKP EEEIVVVYLL LPPCYRTGTE ADDTTDDVPP GTTTLCCTLV TKGG---CCG PYTTLMMMKP EEEIVVVYLL LPPCYRTGTE ADDTTDDVPP ---------- -KGG---CCG PYTTLMMMKP EEEIVVVYLL LPPCYRTGTE ADDTTDDVPP VIIIAEETAA ATCCTAAKKG PYTTLMMMEP EKKLVVVYVV VTTCYNTGIN KDDTTDDLPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- -KGG---CCG PYSSLMMMKP EEEIVVVYLL LPPCYRTGIN KDDTTDDVPP ----VGGVVN KVGGCKKSSG PYSSIMMMSP ESSLIIIYVV VTTAYATGIE KDDTTDDVPP ----VAAVVS KQGGCKKSSG PYSSLMMMSP ETTLIIIYVV VTTAYATGIE KDDTTDDLPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMQVVGGG PYTTLMMMSP EKKLIIIYVV VTTAYTTGID KDDTTDDVPP -------MAA AACCGAATTG PYTTLMMMEP EKKLLLLYVV VTTCYNTGIN KDDTTDDVPP --------MS NKHH-----G PYSSAIIIKP EEEVLLLFVV VTTA--NAAD GDDTTDDVPP --------MP -KHH-----G PYSSAIIIKP EEEVLLLFVV VTTA--HARD GDDTTNNVPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- -SSSCKKCCG PYTTLVVVRP EKKLLLLYVV VVVCQPLDEE HDDTTDDVPP ---------- ---------- -----MMMRP EKKLLLLYTT TVVTQPLDEP HDDTTDDVPP ---------- ---------M PLTT-LLLID RFFLYYYFSS SNNWHGIRQY DTTNNRRMGG F----LLAAG AGPPRAAFFA DTQQPPPPKG EEEFVVVYVV VWWTGVGMGD EDDTTDDLPP VSSSALLVSG AAPPGVVRRA DTAAPKKKKG EDDYVVVYVV VWWTGAGVGD EDDTTDDAPP PSSKKKIIVV HKVPPYYDEE HGGCSSAALC KKPPNIIIRR FLLIIPGGSS RYIITTTKKK PSSKKKVVII YKLPPYYDEE HGGCSSAAYC KKPPFLLLRR YLLIIPAASS RYIVTTTKKK PSSKKKIIVV HTVPPNNDEE HGGCSSSSLS HHAAFLLLRR FLLIIPGGSS RYVITTTKKK PSSQQQIIVV HTVPPNNDEE HGGCSSAALS HHAAFIIIRR YLLIIPGGSS RYIITTTKKK PSSQQQIIVV HQLPPNNDEE HGGCSSAALS HHAAFLLLRR YLLIIPGGSS RYIVVVVKKK PSSSSSIIVV GQVPPHHDEE HGGCSSCCLC HHPPHMMMRR YLLVVPGGSS RYILTTTKKK SSSQQQVVVV GVTPPYYGEE HGGCSSMMLC HHPPHVVVRR YLLVVPDDSS HTILTTTKKK PSSQQQIIVV GRVPPNNDEE HGGCSAAALC HHPPHVVVRR YLLIIPGGSS RHIVTTTKKK PSSQQQVVII HRLPPYYDEE HGGCSSCC-- DDSSTKKKRN KLLIIPGGSS RYVVVVVGGG PSSQQQVVII HRLPPHHDEE HGGCSSCC-- DDSSTKKKRD KLLIIPSSSS RYVVVVVGGG PSSQQQVVII HRLPPNNDEE HGGCSSCC-- DDSSTKKKRT KLLMMPCCSS RYVVVVVGGG PSSQQQVVII HRLPPHHDEE HGGCSSCC-- DDIITKKKRT KLLVVPAASS RYVVVVVGGG PSSQQQVVII HRLPPNNDEE HGGCSSCC-- DDSSTKKKRT KLLVVPSSSS RYVVVVVGGG PSSQQQVVII E--------- ---------- ---------- ---------- ---------- PSSQQQVVII HRLPPNNDEE HGGCSSCC-- DDSSTKKKRT KLLVVPSSSS RYVVVVVGGG PSSQQQVVII HRLPPNNDEE HGGCSSCC-- DDSSTKKKRT KLLVVPSSSS RYVVVVVGGG PSSQQQVVII HRLPPYYDEE HGGCSSCC-- DDSSTKKKRN KLLVVPSSSS RYVVVVVGGG PSSQQQVVII HRLPPNNDEE HGGCSSCC-- DDSSTKKKRT KLLVVPSS-- ---------- PSSQQQVVII HRLPPNNDEE HGGCSSCC-- DDSSTKKKRT KLLVVPSSSS RYVVVVVGGG PSSQQQVVII HRLIIHHDKK HGGCSSCC-- DDPPSAAARR FLLIIPSSSG RYVVTTTAAA ---------- ---PPNNDEE HGGCSSCC-- DDAASKKKRN KLLIIPCCSS RYVVVVVGGG PSSQQQVVII HRLPPNNDEE HGGCSSCC-- DDSSSKKKRN KLLIIPCCSS RYVVVVVGGG PSSKKKVVII HRLPPYYDEE HGGCSSCC-- DDPPSAAARR FLLIIPSSSG RYVITTTKKK PSSKKKVVII HRLPPYYDEE HGGCSSCC-- DDPPSAAARR FLLIIPGGSG RYVITTTKKK ---------- ---PPFFDEE HGGCSSCC-- DDAASAAARR YLLVVPSSSG RYAITTTKKK PSSSSSVVII HRLPPFFDEE HGGCSSCC-- DDAASVVVRR YLLVVPSSSG RYAITTTKKK PSSQQQVVII HRLTTHHDEE HGGCSSCC-- DDPPSAAARR FLLIIPSSSG RYVVTTTLLL PSSQQQVVII SRVPPHHDEE HGGCSSCC-- KKPPTEEERS HLLIIPCCSD RYIIVVVEEE PSSQQQIIII SRVPPNNDEE HGGCSSCC-- KKPPTEEERS HLLIIPCCSD RYVIVVVEEE ---------- ---------- ---------- ---------- -MMVVRKKSG VGKVVVVGGG PSSQQQVVII HRTNNSSNEE HGGCSSCCHF KKEEVPPPRD RLLVVPCCSD RFVITTTGGG PSSQQQIIVV HRTNNRRDEE HGGCSSCCYY KKTTVPPPRD RLLVVPSSSD FYILVVVVVV GVVSSSVVLL KDGKKVVDKK LQQRILKK-- KKRRVQQQGP QMMLLLSSGK RYVTSSSLLL PSSQQQVVII NSVGGGGNEE HGG------- --------RR FFFWWGGGTN RFIFVVVHHH PSSKKKVVVV NTLGGGGNEE HDD------- --------RR YLLWWGGGTS KFVFVVVHHH PPNPPRPPKI IIKKVIIIEE PPEEEVKKKS GGYRHHPDAA YISAAALLNE E-EGPGGGGL PPDKKRPPAV VVKKIVVVEE PPEEEAGGGT GGYKHHPDAA YISAAALLGD DREGPGGGGF PPHPPTAARI IIKKIIIIEE PPDDDIAAAT GGYRHHPEGG YVSTTTLLGD DTDGAPPPGF PPDPPTAAKI IIKKIIIIEE PPEEEVKKKT GGYRHHPDGG YVSTTTLLGD DTNGPPPPGF --EPPLAAKI IIKKIIIIEE PPEEEVAAAT GGYRHHPEGG YVSTTTLLGD DTDGPPPPGF PPDPPLPPFL LLKKVIIIEE PPEEELEEET GGYRHHPGGG YVTAAALLNE E-KGPGGGGA PPDPPTPPKV VVKKVIIIDD PPNNNLEEET GGYRHHPDGG YISAAALLSE E-EGPGGGGF PPDPPRPPRI IIKKVIIIEE PPEEELRRRT GGYRHHPDGG YVSAAALLSE E-DGPGGGGF SSEPPRPPKL LLKKVIIIEE AASSSIAAAC NNVNHHASGG VMVNNNTTGL LGNGKGGGSV SSEPPRPPKL LLKKVIIIEE PPNNNIAAAC NNLNHHASGG VMISSSSSGP PGNGKGGGGV SSDPPRPPKL LLKKVIIIEE AAEEEIAAAC GGLYHHASGG VMISSSTTGS SGNGKGGGGV TTEPPRPPKL LLKKVIIIEE PPKKKITTTC NNLFHHPSGG VMVSSSTTGP PGNGKGGGGV SSEPPRPPKL LLKKVIIIEE PPEEEIAAAC EELFHHASGG VMISSSSSGV VGNGKGGGGV ---------- ---------- PPKKKIAAAC EELFHHASGG VMISSSSSGV VGNGKGGGGV SSEPPRPPKL LLKKVIIIEE PPKKKIAAAC EELFHHASGG VMISSSSSGV VGNGKGGGGV SSEPPRPPKL LLKKVIIIEE PPKKKIAAAC EELFHHASGG VMISSSSSGV VGNGKGGGGV TTEPPRPPKL LLKKVIIIEE AAKKKIEEEC GGLTHHPTGG VMISSSTTGP PGNGKGGGGV ---------- ---------- ---------- ---------- ---------- ---------- SSEPPRPPKL LLKKVIIIEE PPKKKIAAAC EELFHHASGG VMISSSSSGV VGNGKDDDGL TTDPPRPPSL LLKKVVVVEE SSEEEIEEEI GGLFHHASGG IMISSSCCGK KGNAAGGGNF TTDPPRPPRI IIKKTVVVEE PPYYYVWWWC GGLNHHGCGG IMISSSSSGP PGNGKGGGGV SSDPPRPPRI IIKKTVVVEE PPYYYVWWWC GGLNHHGCGG IMISSSSSGP PGNGKGGGGV TTNPPRPPSL LLKKVVVVDD PPAAAIQQQT GGLYHHASGG LMISSSCCGK KGNAEGGGNF TTNPPRPPSL LLKKVVVVEE PPEEEITTTT GGLYHHASGG IMISSSCCGK KGNAEGGGNF EENPPRPPSL LLKKYVVVDD PPKKKIEEET GGLYHHASGG ILVSSSCCGE EGNAKGGGNF EENPPRPPSL LLKKYVVVDD PPKKKIDDDT GGLFHHT-GG ILVSSSCCGE EGNAKGGGNL KKDPPRPPAL LLKKVVVVEE AAEEEIEEET GGLFHHASGG IMISSSCCGK KGNAAGGGNF NNE--RIIYL LLHHTIIIEE PPSSSLSSSN --LFHHADGG IMISSSTTGA AGTPSGGGNL NNE--RIIYL LLHHTIIIEE PPSSSLAAAN --LFHHADGG IMISSSTTGA AGSPSGGGNL GG-------- ---------- ---------- ---------- ---------- ---------- TTDPPRPPKL LLKKVIIIEE GG---VKKKA DDCAHHPNGG IMISSSIIGA AGNAKGGG-F TTDPPRPPEI IIKKTIIIDD GG---VKKKH NNVAHHANGG IMISSSVVGA AGYAKGGG-F YYSAAWKKQF FFPP------ -----LKKKL VVLIHDPNTT LKQDDDGGNS SSVPVLLLNI SSDPPSPPKL LLKKTIIIDD TT---VDDDG GGVGHFPGSS MITGGGLLND DHGGRTTTAV SSDPPAPPVL LLKKTIIITT DD---VKKKG GGVGHYPGRR LITGGGLLNK KHGGRTTTAV SEPLLLLLGK WWIIGGGYY- -------AYD WNLPPPPNVL LVSSSSEEWA VPPPNTIIG- TEPIIIIIGR WWVVGGGYY- -------AYD WNLPPPPSVM MITTTSEEWT VPPPRCFFG- TDVLLLLLGR WWIIGGGDD- -------HYD WNLPPPPRYM MVSSSSEEWA LPPPPQFFG- TEVLLLLLGR WWIIGGGTT- -------HYD WNLPPPPRYM MVTTTSEEWA LPPPPQFFG- TEILLLLLGR YYMMGGGTT- -------HYD WNLPPPPRYM MVSSSSEEWG LPPPPQFFG- SEPLLLLLGR WWVVGGGYY- -------AYD WHLGGGGYTL LVTTTSEEWG TPPPDMVVG- NEVLLLLLGR WWIIGGGYY- -------HYD WHLGGGGYTL LLTTTSEEWG TPPPRMVVG- SDPLLLLLGR WWVVGGGQQ- -------AYD WHLGGGGYTM MVTTTSEEWG TPPPNMIIG- TEVKKKKKGT WWKKGGGPP- -------GYD WQPRRRRHVM MVSSSTEEWA APPPNVFFGF TEVKKKKKGT WWKKGGGPP- -------GYD WQPRRRRHIM MVSSSTEEWA APPPNVFFGF TEVKKKKKGT WWQQGGGPP- -------GYD WQPRRRRHVM MISSSTEEWA APPPNVFFGF TEVKKKKKGT WWQQGGGPP- -------GYD WQPRRRRHVM MISSSTEEWA APPPNVLLGF TEVKKKKKGT WWRRGGGPP- -------GYD WQPRRRRHVM MISSSTEEWA APPPNVLLGF TEVKKKKKGT WWRRGGGPP- -------GYD WQPRRRRHVM MISSSTEEWA APPPNVLLGF TEVKKKKKGT WWRRGGGPP- -------GYD WQPRRRRHVM MISSSTEEWA APPPNVLLGF TEVKKKKKGT WWRRGGGPP- -------GYD WQPRRRRHVM MISSSTEEWA APPPNVLLGF TEVKKKKKGT WWRRGGGPP- -------GYD WQPRRRRHVM MISSSTEEWA APPPNVVVGF ---------- ---------- ---------- ---------- ---------- ---------- RECSSSSSG- ---------- ---------- ---------- -----AIISA HSSSNLRRGS ENVKKKKKGR GGNNFFFSS- -------ERT LENAAAAWLF FWSSSWIIQC CSSSLFYYGA TEVKKKKKGN WWAAEEEPP- -------GYD WQPRRRRHVM MISSSTEEWG APPPKAFFGF TEVKKKKKGN WWVVEEEQQ- -------GYD WQPRRRRHVM MISSSTEEWG APPPKAFFGF DNVKKKKKGR WWKKHHHLL- -------GYD WQPRRRRHTM MISSSTSSWG APPPTAFFGF ENVKKKKKGR WWKKHHHLL- -------GYD WQPRRRRHTM MISSSTSSWG APPPKAFFGF DNIKKKKKNR WWKKHHHLL- -------GYD WQPRRRRHTM MISSSTSSWG APPPKAFFGF DNIKKKKKNR WWKKIIILL- -------GYH WQPRRRRHTM MISSSTSSWG APPPKAFFGF ENVKKKKKGR WWKKHHHLL- -------GYD WQPRRRRHTM MISSSSSSWG APPPAAFFGF TEPKKKKKGT WWAAKKKPP- -------NYD WQPRRRRRVM MISSSTEEWG SPPPNHIIGF TEPKKKKKGT WWAAKKKPP- -------NYD WQPRRRRRIM MISSSTEEWG SPPPNHIIGF ---------- ---------- ---------- ---------- --SSSILLRG GPPPVTVVDE NELVVVVVGT WWRRRRRLL- -------GYD WQPHHHHFVM MVAAASEEWG APPPKLFFGY DNCIIIIIGT WWKKKKKLL- -------GYD WQPYYYYFVM MVSSSSEEWG APPPNKWWGW EGLSSSSSAK GGAAFFFII- -------QLS HNG----RKS SESSSDRRPD EPPPIMAASS GYVAAAAATY WWPPDDDQQA GDAVAGGGYD RLIRRRRKVM MLTTTSSSFT GWWWSMMMGQ GYVAAAAATH WWPPGGGRRA G-KYAGGDYD RLPRRRRKLL LVTTTSSSFT GWWWNMMMGK ELKD--RRRG NNRWDDDLRR KRRRIIIIII SLLGGGEEEN MMAAAAL--- -EEEEELHKM ELKEGGAAAG NNKWDDDLRR RHHHLLLLLL AILGGGQQEH MMVVVVL--- -EEEEEVHKM ELLANNKKKG HHRWDDDLRR RNNNVVVVVV TILGGGAAQH MMAAAAL--- -EEEEEVHRY ELLSNNKKKG HHRWDDDLRR RNNNVVVVVV TILGGGAANH MMAAAAL--- -EEEEEVHRY ELLSNNKKKG HHKWKKKLRR KNNNVVVVVV TILGGGAANH MMAAAAL--- -EEEEEIHKY DLLGAARRRG RRRWDDDLRR RHHHLLLLLL EIFGGGDDEH LLVVVVF--- -EEEEELHKY DLLAGGKKKG HHRWDDDLRR RHHHLLLLLL TLLGGGAAEY MMAAAAL--- -EEEEELHKY QLLNKKGGGG RRRWDDDLRR RHHHLLLLLL ALVGGGEEEH MMVVVVL--- -EEEEELHRY HEA-GGLLLG SSRWDDDWHH EIIIIIIIII TLMTTT---D LLIIIIP--- -EEEEEIHAQ HEA-GGLLLG SSHWDDDWHH EIIIIIIIII TLMKKK---D LLIIIIP--- -EEEEEIHAQ DEA-GGLLLG SSHWDDDWHH EIIIIIIIII TLLQQQ---D LLIIIIP--- -EEEEEIHAQ DKA-GGLLLG SSHWDDDWRR EIIIVVVVVV TLLQQQ---D LLIIIIP--- -EEEEEIHAQ DEA-GGLLLG SSHWDDDWHH EIIIVVVVVV TLLKKK---D LLIIIIP--- -EEEEEIHAQ DEA-GGLLLG SSHWDDDWHH EIIIVVVVVV TLLKKK---D LLIIIIP--- -EEEEEIHAQ DEA-GGLLLG SSHWDDDWHH EIIIVVVVVV TLLKKK---D LLIIIIP--- -EEEEEIHAQ DEA-GGLLLG SSHWDDDWHH EIIIVVVVVV TLLKKK---D LLIIIIP--- -EEEEEIHAQ DEA-GGLLLG KKHWDDDWHH EIIIVVVVVV TLMPPP---D HHIIIIP--- -EEEEEIHAQ ---------- ---------- ---------- ---------- ---------- ---------- PSA-SSRRRA GGI------- ---------- ---------- ---------- ---------- CTA-SSGGGH VVIDNNNYRR VIIIDDDDDD SLLQQQ---D AAGGGGANNI ICCCCCLHIQ EQA-GGMMMG HHSWDDDWHH RRRRIIIIII TILGGGEE-D LLIIIIP--- -EEEEEIHAQ DQA-GGHHHG HHSWDDDWHH RLLLVVVVVV TILGGGKK-D LLIIIIP--- -EEEEEIHAQ HAD-GGLLLG RRHIQQQLGG ELLLRRRRRR TLLGGGNN-T LLLLLLP--- -EEEEEIHKT HAD-GGLLLG RRHYSSSWGG EIIIKKKKKK TLLGGGDD-K LLLLLLP--- -EEEEEIHKT HAD-GGLLLG SSHYSSSWGG EMMMKKKKKK LILGGGEE-T LLLLLLP--- -EEEEEIHKT HAD-GGLLLG SSHYSSSWGG EIIIKKKKKK LILGGGPP-T LLLLLLP--- -EEEEEIHKT HQD-GGLLLG RRHYDDDWGG ELLLKKKKKK TLLGGGSS-T LLLLLLP--- -EEEEEVHKT HGE-GGLLLG NNSFEEEWKK KYYYLLLLLL TILPPPQQPL AALLLLP--- -EEEEEVHSH HPE-GGLLLG NNSFEEEWKK KHHHLLLLLL TILPPPMMPR AALLLLP--- -EEEEEVHSH CPE-PPLLLI KKCY------ ---------- ---------- ---------- ---------- DDDRTTQQQG CCRYRRRWRR ELLLFFFFFF TILGGGDD-D LLTTTTP--- -EEEEEIHEQ DEDMSSQQQG CCRYKKKWQQ TLLLYYYYYY TILGGGSS-D IITTTTP--- -EEEEEIHKE LKTGPPLLLP QQHVLLL--- ---------- ---------- ---------- ---------- DEAMKKRRRG NNTWDDDLRR QPPPKKKKKK VFVPPPGGAP ---------- -EEEEEIWAY DEAMKKHHHG NNTWDDDLKK QPPPKKKKKK VFVPPPGGAP ---------- -EEEEEIWHY GGINSSKDLL IIWLWFY--- DGKNNAKKVV VIEAEEPPLL G-NNLPPEIL LPFFFVLDII GGVNNNKDLL IIWLWFY--- DGKQQARRVV VIDAQQPPFF G-PPLPPPVL LDFFFVLDII GGVGDDTNLL IIWTWWR--- GGKHHVKKTT TATAEEPPAA ADEELPPPLL LGFFFVLDIL GGVGDDTNLL IIWTWWR--- GGKHHAKKTT TATPEEPPAA KEKKLPPPLL LGFFFVLDIL GGCGDDTNLL IIFTWWQKKK DGTEEAKKTT TITPVVPPAA ADDDLPPDLL LGFFFCLDIL GGVNSSKDLL IIWTWYR--- KDKAAVKKVV VIEAEEAAAA PDQQLPPPVL LGFFFVLDIL GGMNSSKDLL IIWLWYR--- NGSHHLKKVV VIDAEEPPAA EDQQLPPPIL LPFFFVLDIL GGVGSSEDLL VVWLWHR--- NGSGGIKKVV VIEAEEPPAA PDQQLPPPLL LDFFFVLDIL GGVGSSNIQQ KKNEEG---- ---------- -TWEKKVVII VPSSKKKVKG GMLLLMLDIL GGVGSSNIQQ KKNEGG---- ---------- -TWEKKVVII VPSSKKKVKG GMLLLMLDIL GGVGSSTIQQ KKNQGG---- ---------- -TWEKKVVII VPPPKKKVKG GMLLLMLDIL GGVGSSTIQQ KKNEDG---- ---------- -TWQKKVVII VPPPKKKVKG GMLLLMLDIL GGVGSSTIQQ KKNEGG---- ---------- -TWEKKVVII VPPPKKKVKG GLLLLMLDIL GGVGSSTIQQ KKNEGG---- ---------- -TWEKKVVII VPPPKKKVKG GLLLLMLDIL GGVGSSTIQQ KKNEGG---- ---------- -TWEKKVVII VPPPKKKVKG GLLLLML--- GGVGSSTIQQ KKNEGG---- ---------- -TWEKKVVII VPPPKKKVKG GLLLLMLDIL GGVGSSTIQQ KKNEGG---- ---------- -TWEKKVVII VPPPKKKVKG GMLLLMLDIL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDDVSSSGRR DDPDAY---- ---------- -AVKRRKKLL LYYYAVVVAK KGVVVLEPAI GGVGSSTVFF KKEKDG---- ---------- -KWEKKVVII VPSSKKKVEG GALLLMLDII GGVGSSSIFF KKEKDG---- ---------- -KWEKKVVII VPSSKKKVEG GPMMMMLDII GGVGSSNMII KKTQDG---- ---------- -SWELLAAII VKPPLKKVQN NILLLMLDFI GGVGTTNMII KKTQDG---- ---------- -SWEIIVVII VEPPLKKVQN NFLLLMLDFI GGVGSSNMII KKNSDD---- ---------- -TWEIIVVII VKPPLKKVEN NILLLMLDFI GGVGSSNMII KKNSDE---- ---------- -TWEVVVVII VKPPLKKVEN NILLLMLDFI GGVGTTNMVV KKTADG---- ---------- -SWEVVAAII IKPPLKKVRN NILLLMLDFI AAVGGGGIFF PPVEENS--- ------TT-- -THTLLVVAA IPSSKKKVSG GALLLMLDII AAVGGGAIFF PPDEKNP--- ------KK-- -VQSLLVVAA IPSSKKKVEN NALLLMLDII ---------- ---------- ---------- ---------- ---------- ---------- GGVGXXXXXX ---------- ---------- ---------- -----QQGEN NEIIIMMDII GGVGNNKVFF KKKSDSD--- ------EEFF FEAVIIDDII GKLLVDDTGS SVAAAMMDII ---------- ---------- ---------- ---------- ---------- ---------- AASTTTQLWW EEDDAG---- ---------- ---------- WQAAKAAVAD DGNNNDLDII CCTSTTQLWW EEDGEG---- ---------- ---------- WQAAKAAVAD DGEEEKLDII SLDDDKKFLL YLWWIIGEEV RRQYDSSSSS FFFKKKPGKV KLGGGIFFHR A--------- SLDDDRRFLL YVWWLLGEEL RRQYDTTTTT HHHQQQPGRV KIGGGLYYHR E--------- SLDDDRRFLL YVWWTTGEEM RRQYDSSSSS HHHNNNPGSV RIGGGIAARR A--------- SMDDDRRFLL YVWWTTGEEM RRQYDSSSSS RRRKKKPGSV HIGGGIAARR T--------- SLDDDKKYLL YVWWLLGEEM HHQYDSSSSS MMMNNNPGKV EIGGGIVVKK T--------- SMDDDRRFLL YVWWTTGDDL LLQYDSSSSS FFFEEEPGKV RIGGGIVVSR AG-------- SVDDDRRFLL YVWWTTGEEL HHQYDSSSSS FFFNNNPGKV QIGGGIVVRR A--------- SLDDDRRFLL YVWWTTGEEL RRQYDSSSSS FFFNNNPGSV RLGGGIVVRK A--------- SLDDDRRFLL YFWWHHGDDI RRQYDSSSSS QQQKKKPGQI FLGGGSIIVR GQVVLLQQTQ SLDDDRRFLL YFWWHHGDDI RRQYDSSSSS KKKKKKPGQI FLGGGSIIVK GQVVLLQQTQ SLDDDRRFLL YFWWHHGDDL RRQYDSSSSS QQQRRRPGQL FLGGGSIIVK GQVVLLQQKQ SLDDDHHFLL YFWWHHGDDI RRQYDSSSSS QQQRRRPGQL FLGGGSIIVK DQVVLLQQDQ SLDDDRRFLL YFWWHHGDDL RRQYDSSSSS QQQRRRPGQL FLGGGSIIVK GQVVLLQQKQ SLDDDRRFLL YFWWHHGDDL RRQYDSSSSS QQQRRRP--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SLDDDRRFLL YFWWHHGDDL RRQYDSSSSS QQQRRRPGQL FLGGGSIIVK GQVVLLEEKQ SLDDDRRFLL YFWWHHGDDM RRQYDSSSSS KKKRRRPGQI FLGGGSIIVK GQVVLLQQKQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FFSSDLLLII IF-------- ---------- ---------- ---------- ---------- SLDDDRRFLL YFWWHHGDDI RRQYDTTTTT RRRNNNPGQI FLGGGSIILR GTVVLLKKEQ SLDDDRRFLL YFWWHHGDDI RRQYDTTTTT RRRNNNPGQI FLGGGSIIQR GTVVLLKKEQ SLDDDRRFLL YFWWHHGDDI RRQYNEEEEE KKKNNNPGQL WVGGGLIIQK GAAAIIDDTQ SLDDDRRFLL YFWWHHGDDI RRQYNEEEEE KKKNNNPGQV WAGGGLIIQK GVAAVVDDTQ SLDDDRRFLL YFWWHHGDDI RRQYNEEEEE KKKNNNPGQI WVGGGLLLQK GKAAVVDDSQ SLDDDRRFII YFWWHHGDDI RRQYNEEEEE KKKNNNPGQI WVGGGLLLQK GKAAVVDDTQ SLDDDRRYLL YLWWHHGDDI RRQYNEEEEE AAAKKKPGQV WAGGGLLLQK GVYYVVDDEQ SMDDDRRFLL YVWWHHGDDI RRQYDSSSSS LLLKKKVSQV YIGGGSVVHT EKVVLLEE-P SMDDDRRFLL YVWWHHGDDI RRQYDSSSSS KKKNNNPSQV FIGGGSIIHS EKVVLLDD-E ---------- ---------- ---------- ---------- ---------- ---------- SLDDDRRYLL YFWWHHGDDV RRQYDSSSSS AAANNNPGQV FLGGGAIIQR DRVVLLPPKA SLDDDRRFLL YVWWHHGDDV RRQYDTTTTT EEENNNPGQL FLGGGAIICS DVIIVVKKKR ---------- ---------- ---------- ---------- ---------- ---------- AADDDQQTLL WIFFDDGKKT RRLFDSSSSS HHHKKKPYEK VIDDRQVVN- ---------- SNDDDSSRLL WVFFDDGKKT RRLFDSSSSS HHHHHHPYEK TIGGAQVVN- ---------- -------AGK KKLLTTGPPQ QMLLISDGRR YVVVTTLYNN QQFYYPPEGL KKKGWWVVKK -------SGE EEAATTGPPQ QMIIVSDGRR YIIITTLYNN QQFYYPP-GL RRRGWWAAKK -------NGT TTFFAAGPPQ QMVVISDGRR YWWWTTLYDD QQFYYPPDGV PPPAAAVVLL -------NGA AAFFAAAPPQ QMVVISDGRR YWWWTTLYDD QQFYYPPDGV PPPGVVVVMM -------NGT TTFFGGYPPQ QMVVISDGKK YWWWTTLYEE QQFYYPPGDR GGGAAAVVMM ------AKNA AALLNNGPPQ QMVVISDGRR YFFFTTLYPP QQFYYPPEGI DDDGWWVVKK ------ATSE EELLNNGPPQ QMVVISDGRR YFFFTTLYEE QQFYYPPDGI KKKGWWVVKK -------ASP PPLLNNGPPQ QMVVVSDGRR YFFFSSLYEE QQFYYPPVGI RRRGWWAAKK PPLLLVVKGR RRIIPPGPPQ QMIILSDGKK YAAATTLYKK QQFYY--PDL IIIREESSVV PPLLLVVKGR RRVVPPGPPQ QMIILSDGKK YVVVTTLYKK QQFYY--PNL IIIREESSVV PPLLLVVKGK KKVVPPGPPQ QMIILSDGKK YVVVTTLYKK QQFYY--PDL IIIREESSVV PPLLLVVKGQ QQVVAAGPPQ QMIILSDGKK YVVVTTLYKK QQFYY--PDL IIIREESSVV PPLLLVVKGR RRVVAAGPPQ QMIILSDGKK YIIITTLYKK QQFYY--PDL IIIREESSVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPLLLVVKGR RRVVAAGPPQ QMIILSDGKK YIIITTLYKK QQFYY--PDL IIIREESSVV PPLLLVVKGR RRVVPPGPPQ QMIILSDGKK YVVVTTLYKK QQFYY--PDL IIIREESSVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPVVVIVKGK KKVVPPGPPQ QMIILSDGKK YVVVTTLYKK QQFYY--PDM IIIKEESSVV PPVVVTVKGI IIIIPPGPPQ QMIILSDGKK YVVVTTLYKK QQFYY--PDL LLLKEEAAVV SVPPPEIQGK KKLLRRGPPQ QMIILTDGKK YVVVTTLFKK QQFYY--PGL VVVEKKSSHH SVPPPEIQGK KKLLRRGPPQ QMIILSDGKK YVVVTTLFKK QQFYY--PKL VVVEQQSSHH FVPPPQIKGS SSLLRRGPPQ QMIILSDGKK YAAATTLFRR QQFYY--PEL MMMDKKSSHH FVPPPQIKGS SSLLRRGPPQ QMIILSDGKK YAAATTLFVV SSFYY--PEI MMMEKKSSHH YVPPPQVKGR RRLLRRGPPQ QMIILSDGKK YVVVTTLFEE QQFYYGGQDL VVVKKKSSHH IALLLYVKGK KKIIEEGPPQ QMLLLSDGKK YVVVTTLYDD QQFYY--PEH VVVKSSAATT IALLLYVKGQ QQIIEEGPPQ QMLLLSDGKK YVVVSSLYDD QQFYY--PEN VVVRSSAATT ---------- ------GPPA AKIILSDGKK YVVVTTFYKK QQFYY--PNV VVVKEESSVV PPVVVFLKGR RRLLLLGPPQ QMLLLSDGRR YVVVSSLFKK QQFYY--PEM VVVAAAGGTT PARRRYVKGR RRLLEEGPPQ QMLLLSDGKK YVVVSSLYKK QQFYY--PKM VVVSQQGGHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MVVQSDGKK YFFFSSLL-- ---------- ---KKKKKDD ---------- ---------- -MVVSSDGQQ YYYYTTLL-- ---------- ---KKKKKDD NAAANN--GG GGGGLEEEEI KEFFFDG--- --------RQ VRLLSSSGGS DSYCYP---- NVVVNN--GG GGGGLEEEEL KEFFFDG--- --------RQ VRLLWWWGGT DSFCYP---- HAAAGG--GG GGGGLTTTTL DDYYWEPG-- --------RQ IRLLEEEGGT DSFCYPSVVV NVVVGG--GG GGGGLEEEEL KDYYFSPG-- --------RQ IRLLEEEGGT DSFCYPSVVV NVVVGG--GG GGGGLTTTTL KDFFWDPG-- --------RQ IRLLEEEGGT DSFCYPSVVV DAAAGG--GG GGGGIEEEEF PKFFFEPG-- --------RQ VRLLQQQGGS DSYCYP---- DVVVNN--GG GGGGMQQQQF PNFFFDG--- --------RQ IRLLQQQGGS DSYCFP---- EAAADD--GG GGGGLSSSSL PGFFFEGG-- --------RQ IRLLEEEGGS DSYCYPS--- LQQQVVDDGG GGGGLKKKKL PNFFLDGEPP PPPLGGPPLE LRYYPPPGGS DIWI------ LQQQIIDDGG GGGGLKKKKL PNFFLDGEPP PPPLGGPPLE LRYYPPPGGS DIWI------ LQQQIIDDGG GGGGLKKKKL PNFFLDGEPP PPPLGGPPLE LRYYPPPGGS DIWL------ LQQQIIDDGG GGGGLTTTTL PNFFLDGEPP PPPLGGPPLE LRYYPPPGGS DIWL------ LQQQVVDDGG GGGGLKKKKL PNFFLDGEPP PPPLGGPPLE LRYYPPPGGS DIWI------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LQQQVVDDGG GGGGLKKKKL PNFFLDGEPP PPPLGGPPLE LRYYPPPGGS DIWI------ LQQQIIDDGG GGGGLKKKKL PNFFLDGEPP PPPLGGPPLE IRYYPPPGGS DIWL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LQQQIIDDGG GGGGLKKKKL PNFFLDGEPP PPPGGGPPLE LRYYPPPGGS DIWV------ LQQQIIDDGG GGGGLKKKKL PNFFLDGEPP PPPDGGPPLE IRYYPPPGGS DIWI------ LQQQIIDDGG GGGGLKKKKI PNFFFDGEPP PPPDGGPPLE MRYYPPPGGS DIWI------ LQQQIIDDGG GGGGLKKKKI PNFFFDGEPP PPPDGGPPLE MRYYPPPGGS DIWI------ IQQQIIDDGG GGGGLSSSSI PNFFFDGEPP PPPEGGPPLE MRYYPPPGGS DIWI------ IQQQIIDDGG GGGGLTTTTI PDFFFDGEPP PPPDGGPPLE MRYYPPPGGS DIWI------ LQQQIIDDGG GGGGLSSSSI PNFFFDGEPP PPPEGGPPLE MRYYPPPGGS DIWI------ VQQQVVNDGG KKKKMEEEEI RDFFLDGIEE EEEGGGPPLE MRYYPPPGGS DIWI------ LQQQIIDDGG HHHHMVVVVI KNFFLDGVPP PPPGGGPPLE MRYYPPPGGS DIWI------ LQQQIIDDGG GGGGLTTTTV KNFFLDGEPP PPPNGGPPLD IRFFPPPCGS DILA------ VQQQLLDDGG GGGGMKKKKL ENFFLDGEPP PPPYGGPPLE MR-------- ---------- VLLLIIDDGG GGGGISSSSL EDFFLDAEPP PPPYGGPPLE MRYYPPPGGS DIWLANDAAA ---------- ---------- ---------- ---------- ---------- ---------- AQQQYYLADD GGGGKEEEEL EDFFADYLGG GGGLGG--RI MRFFGGGSSS S--------- EQQQFFLLDD GGGGKEEEEL EQFFADYEKK KKKLGG--RQ MRFFGGGARA GPAGDGNRRR ------- ------- KK----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLARREE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSAKAKKKKK PSSSATTPCC CCRRRTTAVG TTARLLGGAM MMMQLRRTTT AAQQLLLSTT gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GPRRRRIKKA AAAAWTTAAI QQREESSRKR VVPPLLVEEE AAAAQVVVVV PQAAVVQQQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---SAPPPPL NNHNNPPPAP HHPPVVPLLL VVVVRTTTII NPPRLLPPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMMAIIIKRT YYPPPSPKKK KEELAYVVVA ---------- ---------- ---------- ----MMMKPT YYPPPTPRRR REEIAYVVVA ---------- ---------- ---------- -------RPT HHAAASPEQQ QEEFAYTTTL ---------- ---------- ---------- -------RPT HHAAASPKEE EEEFAYTTTL ---------- ---------- ---------- -------RPT YYPPPSAKEE EEELAFTTTL ---------- ---------- ---------- ----MMMKPS YYPPPSPRKK KEEIAYVVVA ---------- ---------- ---------- ----MMMRPT YYPPPSPRKK KEELAYVVVV ---------- ---------- ---------- ----MMMRPT YYPPPSPKQQ QEELGYVVVA ---------- ---------- -------MMA TTTKCCC-CG PPTTTPLE-- -EEIVYLLLP ---------- ---------- ---------- ---------- ---------- -EEIVYLLLP WHHHLPPGHH GGGAAVIIIA RGLPGGAHHS TTTQCCC-CG PPSSSPLE-- -EEIVYLLLP ---------- ---------- ---------- ---------- ---------- -EEIIYLLLP ---------- ---------- -------MMA TTTKCCC-CG SSTTTPLE-- -EEIVYLLLP -----AAREE GGGAFTQQQA QPRPIISTTA TTTKCCC-CG SSTTTPLE-- -EEIVYLLLP ---------- ---------- -------MMA TTTKCCC-CG SSTTTPLE-- ---------- ---------- ---------- -------MMA TTTKCCC-CG SSTTTPLE-- -EEIVYLLLP -MMMLGGEPP GGGHTAPPPL SGLWQQDTTA TTTKCCC-CG PPTTTPQE-- -EEIVYLLLP LKKKSQQCGG FFFDQTTTTH TYTLVVTSSP TTTKCCC-CG SSTTTPLE-- -EEIVYLLLP ---------- ---------- -------MMA TTTKCCC-CG SSTTTPLE-- -EEIVYLLLP CPPPARRSVV LLLQHIEEEA AVTAAAANNG KKKTCCCAKG AATTTPLEKK KEELVYVVVT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M AAAKCCC-CG KKSSSPLD-- -EEIVYLLLP ---------- ------AAAL DHVVNNKKKS ---VNNNKSG AASSSPIE-- -EELIYVVVT ---------- ------GGGL QHVVSSKVVN NNNQQQQKSG AASSSPLE-- -EELIYVVVT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RRRVGG AATTTPLA-- -EELIYVVVT ---------- ---------- --MAAAANNG AAAACCCATG AATTTPLEKK KEELLYVVVT ---------- ---------- ---MSSNCCG LLLKCCC--G AASSSPAD-- -EEVLFVVVT ---------- ---------- ---MPP-CCP LLLKCCC--G AASSSPAD-- -EEVLFVVVT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMMSEEEKCG AATTTPLDNN NEELLYVVVV ---------- ---------- ---------- ---------- --------SS SEELLYTTTV ---------- ---------- ---------- ---------G IITTT--DSS SRRLYFSSSN ----MKKRFF GGG------- -AAAGGALLA MMMGLLLAFE CCQQQSPYII IEEFVYVVVW ----MKKFVV SSSGPSHHHL RAVSGGALLA LLLAAAAVRE CCAAASPYII IEEYVYVVVW AACCCLLYTT TNRDAVVVVD VVVNPSTTSV VEELPPYNEE EHHHHHHGWW SSALLCC--P AAAAALLYVV VNADAVVVVD VVVDPSTTGL LDDLPPYGEE EHHHHHHGWW SSAYYCC--P LLLLLLLSPP P-RDAVVVID VVVKPSTTGV VTTMPPNGEE EHHHHHHGWW SSSLLSS--P LLLLLLLSPP P-KDAVVVID VVVKPSTTGV VTTMPPNGEE EHHHHHHGWW SSALLSS--P LLMMMLLSPP P-KDAVVVVD VVVDPSKKGL LIIMPPNGEE EHHHHHHGWW SSALLSS--P AAMMMFFDPP P-QDAVVVVD VVVDPSRRAV VAAMPPHGEE EHHHHHHGWW SSCLLCC--P VVRRRLLNPP P-KDCVVVVD VVVDSSTTGT TDDMPPYGEE EHHHHHHGWW SSMLLCC--P AALLLLLDPP P-RDGVVVLD LLLDPSTTAV VEEMPPNAEE EHHHHHHGWW SSALLCC--P PPCCCIIYRR READATTTVD VVVDPSQQSL LPPMPPYKEE EHHHHHHGWW SSC------- PPCCCIIYRR READATTTVD VVVDPSHHSL LPPMPPHKEE EHHHHHHGWW SSC------- PPCCCIIYGG GEADATTTVD IIIDPSQQCL LPPMPPNREE EHHHHHHGWW SSC------- PPCCCIIYRR READATTTVD VVVDPSQQCL LPPMPPHKEE EHHHHHHGWW SSC------- PPCCCIIYRR READATTTVD VVVDPSQQCL LPPMPPNKEE EHHHHHHGWW SSC------- PPCCCIIYRR READATTTVD VVVDPSQQC- ---------- ---------- ---------- ---------- -EADATTTVD VVVDPSQQCL LPPMPPNKEE EHHHHHHGWW SSC------- PPCCCIIYRR READATTTVD VVVDPSQQCL LPPMPPNKEE EHHHHHHGWW SSC------- PPCCCIIYRR READATTTVD VVVDPSQQSL LPPMPPYKEE EHHHHHHGWW SSC------- PPCCCIIYRR READATTTVD VVVDPSQQCL LPPMPPNKEE EHHHHHHGWW SSC------- PPCCCIIYRR READATTTVD VVVDPSQQCL LPPMPPNKEE EHHHHHHGWW SSC------- TTCCCVVYNN NNKDATTTVD LLLDPSTTSL LPPVIIHGKK KHHHHHHGWW SSC------- ---------- ---------- ---------- ---MPPNNEE EHHHHHHGWW SSC------- PPCCCIIYRR RNKDATTTVD VVVDPSSSSL LPPMPPNNEE EHHHHHHGWW SSC------- TTAAAVVYAA AEKDATTTVD VVVDPSTTSL LPPVPPYGEE EHHHHHHGWW SSC------- TTAAAVVYAA AEKDATTTVD LLLDPSTTSL LPPVPPYGEE EHHHHHHGWW SSC------- ---------- ---------- ---------- ---MPPFGEE EHHHHHHGWW SSC------- TTAAAVVYTT TDKDATTTVD VVVDPSSSSL LPPMPPFGEE EHHHHHHGWW SSC------- TTCCCVVYNN NNKDGTTTVD VVVDPSTTSL LPPVTTHGEE EHHHHHHGWW SSC------- TTAAAPP--- -DGDFTTTVD VVVNPSTTCV VDDVPPHGEE EHHHHHHGWW SSC------- TTAAAPP--- -DGDFTTTVN VVVNPSTTCV VDDVPPNGEE EHHHHHHGWW SSC------- ---------- ---------- ---------- ---------- ---------- ---------- VVCCCVVQPP PEHDATTTVD VVVDPSTTCT TYYTNNSHEE EHHHHHHGWW SSCHHFFVVP VVTTTVVQPP PPHDSTTTVD VVVDPSTTCT TFFTNNRGEE EHHHHHHGWW SSCYYYYVVD NNWWWLLHGG GYDTKNNNPR MMMVGVLLGG GPPVKKVEKK KLLLLDDQPP IIK------- WWTTTLLGVV VDEDVTTTID LLLRPSTTGV VSSVGGGREE EHHHHHHGFF ---------- WWTTTLLGAA ADEDVTTTVD AAANPSQQGL LSSVGGGREE EHHHHHHDFF ---------- NNGG-KPPNN FLLLLLIIVV VGLRYIIDDT TKPEPPPKII IIIIIIIIVV EVVVKGHHHT NNAA-KPPFF YLLLLLIIVV VALRYIVDDT TKKRPPPAVV VVVVAAAAII EAAAVGHHHT LLTTGHAAFF FLLLLLIIII IGLRYVIDDT TKPQAAARII IIIIHHHHII EIIILGHHHT LLAAGHAAFF YLLLLLIIII IGLRYIIDDT TKPKAAAKII IIIIHHHHII EVVVFGHHHT LLTTGHAAFF YLLLLLIIII IGIRYIVDDV VKPKAAAKII IIIIHHHHII EVVVFGHHHT NNAAPHPPHH YLLLLLVVVV VGLRYILDDT TKPKPPPFLL LLLLAAAAVV ELLLAGHHHT NNAAPHPPHH YLLLLLVVVV VDIRTILDDT TKPQPPPKVV VVVVVVVVVV DLLLAGHHHT YYAAPHPPHH YLLLLLIIVV VGIRHIVDDT TKPEPPPRII IIIIVVVVVV ELLLHGHHHT --FFGDSSTT KLLLLLIILL LGLMYVVDDV VGPAPPPKLL LLLLHHHHVV EIIIQNHHHT --FFGDSSTT KLLLLLIILL LSIIYVVDDV VGPAPPPKLL LLLLHHHHVV EIIIHNHHHT --FFGDSSTT KLLLLLMMLL LCLMYVVDDV VGPAPPPKLL LLLLHHHHVV EIIIHGHHHT --YYGDIITT KLLLLLVVLL LALIYVVDDV VGPAPPPKLL LLLLHHHHVV EIIIHNHHHT --FFGDSSTT KLLLLLVVLL LSLIYVVDDV VGPAPPPKLL LLLLHHHHVV EIIIHEHHHT ---------- ---------- ---------- ---------- ---------- -IIIHEHHHT --FFGDSSTT KLLLLLVVLL LSLIYVVDDV VGPAPPPKLL LLLLHHHHVV EIIIHEHHHT --FFGDSSTT KLLLLLVVLL LSLIYVVDDV VGPAPPPKLL LLLLHHHHVV EIIIHEHHHT --FFGDSSTT KLLLLLVVLL LSFIYVVDDV VGPAPPPKLL LLLLHHHHVV EIIIHGHHHT --FFGDSSTT KLLLLLVVLL LSL------- ---------- ---------- ---------- --FFGDSSTT KLLLLLVVLL LSLIYVVDDV VGPAPPPKLL LLLLHHHHVV EIIIHEHHHT --HHGDPPSS FLLLLLIILL LSLLYVVDDT TAPTPPPSLL LLLLHHHHVV EIIIAGHHHT --YYGDAASS KLLLLLIILL LCLIYVVDDV VGPAPPPRII IIIIHHHHTT EVVVFGHHHT --YYGDSSSS KLLLLLIILL LCLIYVVDDV VGPAPPPRII IIIIHHHHTT EVVVFGHHHT --HHGDPPSS FLLLLLIIAA ASLVYVIDDT TKPSPPPSLL LLLLHHHHVV DIIIIGHHHT --HHGDPPSS FLLLLLIIVV VGIVYVIDDT TKPAPPPSLL LLLLHHHHVV EIIISGHHHT --HHGDAASS YLLLLLVVLL LSLIYAIDDT TKPAPPPSLL LLLLYYYYYY DIIIAGHHHT --HHGDAASS YLLLLLVVLL LSLIYAIDDT TKPAPPPSLL LLLLYYYYYY DIIIAGHHHT --HHGDPPSS FLLLLLIILL LSLLYVVDDT TLPAPPPALL LLLLHHHHVV EIIIAGHHHT --HHDKPPTT HLLLLLIIVV VCLNYIINNV VE-KIIIYLL LLLLEEEETT ELLLH-HHHT --HHDKPPTT HLLLLLIIVV VCLNYVINNV VE-EIIIYLL LLLLQQQQTT ELLLH-HHHT ---------- -MMMMMVVPP PKLSGKVFFV VG-------- ---------- ---------- --GGGKEEVV RLLLLLVVLL LCLNFVIDDT TGPAPPPKLL LLLLAAAAVV EVVVLDHHHT EESSSKTTVV RLLLLLVVLL LSLNYILDDV VVPKPPPEII IIIIVVVVTT DVVVLNHHHT ----GKRRVV QMMMMMLLQQ QSLDYVTTTS SLADKKKQFF FFFFYYYY-- -LLLIVHHHT ---------- FFFFFFWWTT TGLDFIFDDV VHPNPPPKLL LLLLHHHHTT DVVVKGHHHT ---------- YLLLLLWWAA AGLDFVFDDV VHPRPPPVLL LLLLSSSSTT TVVVEGHHHT HCGGPIIYYI ISG-EEEG-E EEGGGGIILM DHHYSLGGER GDDYYY---- -----LYDWN HCGGPIIYYI ISG-DDDGRE EEGGGGIIFL DHHDTIGGER GPPYYY---- -----FYDWN HCGGPIIYYV VSGGDDDGTD DDGGGGIIFI DCCETLGGER GPPDDD---- -----KYDWN HCGGPIIYYV VSGGDDDGTN NNGGGGVVFI DCCETLGGER GPPTTT---- -----LYDWN HCGGPIIYYV VSGGDDDGTD DDGGGGIIFI DCCETLGGER GEETTT---- -----KYDWN HCGGPIIYYV VTG-EEEG-K KKGGGGIIAM DAAQSLGGER GPPYYY---- -----FYDWH HCGGPIIYYI ISG-EEEG-E EEGGGGIIFI DHHDNLGGER GDDYYY---- -----LYDWH HCGGPVVYYV VSG-EEEG-D DDGGGGVVFV DHHESLGGER GPPQQQ---- -----LYDWH HCLLAEEVVM MVL-LLLQGN NNSSSSFFVL DGGETKGGEG GAAPPP---- -----MYDYQ HCLLAEEVVM MIL-PPPQGN NNGGGGFFVL DGGETKGGEG GEEPPP---- -----MYDYQ HCLLAEEVVM MIL-SSSKGN NNGGGGFFVL DGGETKGGEG GAAPPP---- -----MYDYQ HCLLPEEVVM MVL-PPPEGN NNGGGGFFVL DGGKTKGGEG GAAPPP---- -----LYDYQ HCLLAEEVVM MIL-VVVKGN NNGGGGFFVL DGGETKGGEG GAAPPP---- -----SYDYQ HCLLAEEVVM MIL-VVVKGN NNGGGGFFVL DGGETKGGEG GAAPPP---- -----LYDYQ HCLLAEEVVM MIL-VVVKGN NNGGGGFFVL DGGETKGGEG GAAPPP---- -----LYDYQ HCLLAEEVVM MIL-VVVKGN NNGGGGFFVL DGGETKGGEG GAAPPP---- -----LYDYQ HCLLPEEVVM MIL-PPPKGN NNGGGGFFVL DGGETKGGEG GSSPPP---- -----MYDYQ ---------- ---------- ---------- ---------- ---------- ---------- HCLLAEEVVM MIL-VVVKGN NNGGGGSSLV LPP-RSGG-- ---------- ---------- HCLLADDIIM MIL-KKKEGN NNNNNNGGFL LDDSEKGGSL FPPSSS---- -----KRTYE HCLLGEEIIM MII-PPPYGN NNGGGGFFVL DGGETKGGEG EAAPPP---- -----FYDYQ HCLLGEEIIM MIL-PPPCGN NNGGGGFFVL DGGETKGGEG ESSQQQ---- -----FYDYQ HCLLAEELLM MIL-KKKDGN NNNNNNGGFL LDDSDKGGEG HSSLLL---- -----FYDYQ HCLLAEEIIM MII-KKKDGN NNNNNNGGFL LDDSEKGGEG HSSLLL---- -----FYDYQ HCLLAEEIIL LVL-EEEEGN NNNNNNGGFL LDDSDKNNEG HSSLLL---- -----FYDYQ HCRRTEEIIL LVL-EEEEGN NNNNNNGGLL LDDSDKNNED ISSLLL---- -----YYHYQ HCLLAEEIIM MIL-KKKEGN NNNNNNGGFL LDDSEKGGEG HSSLLL---- -----FYDYQ HCLLANNIIM MIL-AAANGT TTNNNNFFLL DGGKTKGGPE KTTPPP---- -----FYDYQ HCLLANNIIM MIL-AAADGS SSNNNNFFLL DGGKTKGGPG KVVPPP---- -----FYDYQ ---------- ---------- ---------- ---------- ---------- ---------- HCLLPNNIIM MIM-AAAEGN NN----DDFV FDDKNVGGSD RKKLLL---- -----CYDYQ HCLLANNIIM MIM-AAAEGY YY----DDFI FDDSDIGGTD KKKLLL---- -----CYDYQ DYQQPAALLK KQV-SSSLSV VVNNNNGGIQ SKKHESAAEQ FEEIII---- -----LLSNN FALLPMMMMI ITS-DDDDHG GGAAAALLVE NDDDGATTMA DDDQQQAGDD AAADGYYDAL YALLPMMLLI ITS-KKKDHG GGAAAALLVE TNNAGATTID GDDRRRAG-- KKKDGYYDAL LL-PPNNEVV SEEAVVP--I DDG--LDD-- RRYNRIIHHF DDRKKKHSTG GEERRMM--- LL-PPSSGII SEETVVP--F EEG--LEEGG AAYNKLLHHV DDAKRRYADG GQERRMM--- LL-PPRRDVV SEEALLP--F NNG--LAANN KKYHRLLHHF DDRARRQTDG GAQQQMM--- LL-PPRRDVV SEEALLP--F NNG--LSSNN KKYHRLLHHF DDRARRQTDG GANQQMM--- LL-PPRRDVV SEEGLLP--F NNG--LSSNN KKYHKIIHHF KKRDKKQTDG GANQQMM--- LL-GGYYDVV SEEGTTP--V DDG--LGGAA RRYRRLLHHF DDTRRRQEDG GDEQQLL--- LL-GGYYDLL SEEGTTP--V SSG--LAAGG KKYHRLLHHV DDYRRRQTDG GAEQQMM--- LL-GGYYDVV SEEGTTP--I GGG--LNNKK GGYRRLLHHI DDRRRRQADG GEEQQMM--- PP-RRHHNVV TEEAAAP--F DDGFFE--GG LLYSRIIFFV DDQREEQTQT T--GGLL--- PP-RRHHNVV TEEAAAP--F DDGFFE--GG LLYSHIIHHV DDQREEQTQK K--GGLL--- PP-RRHHNII TEEAAAP--F DDGFFE--GG LLYSHLLHHV DDQREEQTTQ Q--GGLL--- PP-RRHHNII TEEAAAP--L DDGFFK--GG LLYSHLLYYV DDQREEQTPQ Q--GGLL--- PP-RRHHNII TEEAAAP--L DDGFFE--GG LLYSHLLYYV DDQHEEQTSK K--GGLL--- PP-RRHHNII TEEAAAP--L DDGFFE--GG LLYSHLLYYV DDQREEQTSK K--GGLL--- PP-RRHHNII TEEAAAP--L DDGFFE--GG LLYSHLLYYV DDQREEQTSK K--GGLL--- PP-RRHHNII TEEAAAP--L DDGFFE--GG LLYSHLLYYV DDQREEQTSK K--GGLL--- PP-RRHHNII TEEAAAP--V NNGFFE--GG LLYKHLLHHV DDQREEQTLP P--GGHH--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AIIAHHS--R TTGSSS--SS RRVGITT--- ---------- ---------- NNYAAWWGWW WIICCCS--Y TTGAAT--SS GGVVISSCCL NNIMVVESPQ Q--QQAANPP PP-RRHHNII TEEGAAP--F LLGFFQ--GG MMYHSLLNNV DDTERRQTDG GE-GGLL--- PP-RRHHNII TEEGAAP--F LLGFFQ--GG HHYHSLLNNV DDTERRQTDG GK-GGLL--- PP-RRHHNII TSSGAAP--F KKGFFA--GG LLYRHLLTTC QQAREEQTDG GN-GGLL--- PP-RRHHNII TSSGAAP--F QQGFFA--GG LLYRHLLHHV SSPGEEQTDG GD-GGLL--- PP-RRHHKII TSSGAAP--F KKGFFA--GG LLYSHLLHHV SSPGEEQLDG GE-GGLL--- PP-RRHHKII TSSGAAP--F KKGFFA--GG LLYSHLLHHV SSPGEEQLDG GP-GGLL--- PP-RRHHKII SSSGAAP--F TTGFFQ--GG LLYRHLLHHV DDPGEEQTDG GS-GGLL--- PP-RRRRNII TEEGSSP--I KKGFFG--GG LLYNSVVHHI EEDSKKQTDP PQPGGAA--- PP-RRRRNII TEEGSSP--I KKGFFP--GG LLYNSVVHHI EEDTKKQTDP PMPGGAA--- ---------- ILLGGGP--V RRDEEP--PP LLVKCKKRRV ---------- ---------- PP-HHFFNVV SEEGAAP--F RRGYYDRRTT QQYCRLLNNF RRQEEEQTDG GD-GGLL--- PP-YYFFDVV SEEGAAP--W RRGWWEMMSS QQYCRLLNNF KKSTTTQTDG GS-GGII--- GG---RREEE DRRDEEP--A EESSSKGGPP LLKQHVVAAE LL-------- ---------- II-RRKKNLL SSSTGGWNNM FFGQQEMMKK RRFNTIIVVQ DDHTQQKVNP PGA------- PP-RRKKNVV SSSTGGWNNM FFGKKEMMKK HHFNTVVVVT DDHTQQKVDP PGA------- -LRLHTLMMF INMVVVVSLL LLSSIWWFFE DDGWNKVIII EIPPAPPLEE G-LLPILLLK -VRLHTLMMF VNVVVLLNTT TTSSIWWFFE DDGWQRVIII DIEEAPPFEE G-LLPVLLLK -VRAHVEYYF VGVVVVVDTT TTSSIWWWWE GGGFHKTAAA TIPPAPPATT ADLLPLLLLQ -VRAHVEYYF VGVVVVVDTT TTSSIWWWWE GGGFHKTAAA TIPPPPPAPP KELLPLLLLQ -IRAHSDYYF CGVVVVVDTT TTAAIWWWWD DDGFEKTIII TIDDPPPADD ADLLPLLLLK -LRAHTAYYF VNCVVIISLL LLSSIWWYYD KKDWAKVIII EIPPAAAADD PDLLPVLLLK -LRAHTAYYF MNCVVVVSLL LLSSIWWYYD NNGWHKVIII DIPPAPPASS EDLLPILLLK -LRAHATYYF VGVVVVVSLL LLSSVWWHHQ NNGWGKVIII EIPPAPPAEE PDLLPLLLLK LIRLHSTQQF VGCAALLSSS SSYYKEEGG- -------TTT WSVVEVVIQQ VPKKKKGGGW LIRLHDTQQF VGCAALLSSS SSYYKGGGG- -------TTT WSVVEVVIQQ VPKKKKGGGW LIRLHDAQQF VGCAALLSSS SSYYKGGGG- -------TTT WSVVEVVIQQ VPKKKKGGGW LIRLHDAQQF VGCAALLSSS SSFFKDDGG- -------TTT WSAAQVVIQQ VPKKKKGGGW LIRLHDAQQF VGCAALLSSS SSYYKGGGG- -------TTT WSVVEVVIQQ VPKKKKGGGW LIRLHDAQQF VGCAALLSSS SSYYKGGGG- -------TTT WSVVEVVIQQ VPKKKKGGGW LIRLHDAQQF VGCAALLSSS SSYYKGGGG- -------TTT WSVVEVVIQQ VPKKKKGGGW LIRLHDAQQF VGCAALLSSS SSYYKGGGG- -------TTT WSVVEVVIQQ VPKKKKGGGW LIRLHASQQF VGCAALLSSS SSYYKGGGG- -------TTT WSVVEVVIEE VPKKKKGGGW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLRIHNNQQY DVVEEVVSFF FFSSDAAYY- -------AAA VVLLKKKLDD LYAAVAKKKF LIRLHDAQQL VGCAALLSSS SSYYKDDGG- -------KKK WAAAEVVIKK VPKKKEGGGW LIRLHDDQQL VGCAALLSSS SSYYKDDGG- -------KKK WAAAEVVIQQ VPKKKEGGGW LIRLHADTTF VGSAALLSSS SSFFKDDGG- -------SSS WSHHEAAIPP VKLLKQNNNW LIRLHADTTF VGSAALLTSS SSFFKDDGG- -------SSS WNHHEVVISS VELLKQNNNW LIRLHSDTTY VGSAALLSSS SSFFKDDDD- -------TTT WSYYEVVISS VKLLKENNNW LIRLHSDTTF VGSAALLSSS SSFFKDDEE- -------TTT WSHHEVVISS VKLLKENNNW LVRLHSDTTY VGCAALLTSS SSFFKDDGG- -------SSS WSHHEAAISS IKLLKRNNNW LVRLHTEHHF VGCAALLGSS SSHHPEENN- -----T-TTT HAAATVVAFF IPKKKSGGGW LVRLHTEHHF VGCAALLGSS SSHHPKKNN- -----K-VVV QTAASVVATT IPKKKENNNW ---------- ---------- ---------- ---------- ---------- ---------- LIRLHRNQQY VGCAAFFXXX XXXX------ ---------- ---------- ----QENNNG LIRLHKAEEF VGCAALLNAA AAKKKDDSS- -----EFEEE AKKKVDDIPP GKVVDGSSSG ---------- ---------- ---------- ---------- ---------- ---------- LIRPWNNYYF STTAALLTSS SSYYEAAGG- ---------- --------EE WQKKAADDDI LIRAWANYYF TSTAALLTSS SSYYEEEGG- ---------- --------EE WQKKAADDDI PPPFKAPPPL VTDIIDDLLK KFLYLWWWGI IGEVVRYYDN KPVLTTGVKL IIIFFAP--- DDDFKMPPPL VTDIIDDLLR RFLYVWWWGL LGELLRYYDN QPRLAAGVKI LLLYYEP--- GGGFGAPPPL VTDIIDDLLR RFLYVWWWGT TGEMMRYYDD NPVLAAGVRI IIIAAAP--- GGGFGAPPPL VTDIIDDMMR RFLYVWWWGT TGEMMRYYDD KPKLAAGVHI IIIAATP--- GGGFGAPPPL VTDIIDDLLK KYLYVWWWGL LGEMMHYYDD NPVLTTGVEI IIIVVTP--- GGGFKAPPPL VTDIIDDMMR RFLYVWWWGT TGDLLLYYDD EPKLTTGVRI IIIVVAPGG- PPPFKAPPPL VTDIINNVVR RFLYVWWWGT TGELLHYYDD NPRLTTGVQI IIIVVAP--- DDDFGAPPPL VTDIINNLLR RFLYVWWWGT TGELLRYYDD NPRHTTGVRL IIIVVAP--- MMMLPEPGGL ITDIILLLLR RFLYFWWWLH HGDIIRYYDN KPRLTTGIFL SSSIIGVQQV MMMLPEPGGL ITDIILLLLR RFLYFWWWLH HGDIIRYYDN KPRLTTGIFL SSSIIGVQQV MMMLPEPGGL ITDIILLLLR RFLYFWWWLH HGDLLRYYDD RPRLTTGLFL SSSIIGVQQV MMMLPEPGGL ITDIILLLLH HFLYFWWWLH HGDIIRYYDD RPRLTTGLFL SSSIIDVQQV LLLLPEPGGL ITDIILLLLR RFLYFWWWLH HGDLLRYYDD RPRLTTGLFL SSSIIGVQQV LLLLPEPGGL ITDIILLLLR RFLYFWWWLH HGDLLRYYDD RPRL------ ---------- LLLLPEPGGL IT-------- ---------- ---------- ---------- ---------- LLLLPEPGGL ITDIILLLLR RFLYFWWWLH HGDLLRYYDD RPRLTTGLFL SSSIIGVQQV MMMLPEPGGL ITDIILLLLR RFLYFWWWLH HGDMMRYYDD RPRLVVGIFL SSSIIGVQQV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGVVSSNNE FPPAAWWFFL LLIIF----- ---------- ---------- ---------- AAALPEPGGL ITDIILLLLR RFLYFWWWLH HGDIIRYYDD NPKLVVGIFL SSSIIGVTTV PPPMPEPGGL ITDIILLLLR RFLYFWWWLH HGDIIRYYDD NPKLVVGIFL SSSIIGVTTV IIILPEPGGL ITDFFLLLLR RFLYFWWWLH HGDIIRYYND NPVLTTGLWV LLLIIGVAAA FFFLPEPGGL ITDFFLLLLR RFLYFWWWLH HGDIIRYYND NPKLTTGVWA LLLIIGVVVA IIILPEPGGL ITDFFLLLLR RFLYFWWWLH HGDIIRYYND NPVLTTGIWV LLLLLGVKKA IIILPEPGGL ITDFFLLLLR RFIYFWWWLH HGDIIRYYND NPVLTTGIWV LLLLLGVKKA IIILPEPGGL ITDFFVVLLR RYLYLWWWLH HGDIIRYYND KPVLAAGVWA LLLLLGVVVY AAALPEPAAL ITDIILLMMR RFLYVWWWLH HGDIIRYYDD KVKLNNSVYI SSSVVEVKKV AAALPDPAAL ITDIILLMMR RFLYVWWWLH HGDIIRYYDD NPKLNNSVFI SSSIIEVKKV ---------- ---------- ---------- ---------- ---------- ---------- EEEIEMGGGM MTDIILLLLR RYLYFWWWRH HGDVVRYYDD NPRLTTGVFL AAAIIDRRRV VVVAEDGGGM ISDIIIILLR RFLYVWWWRH HGDVVRYYDD NPKLTTGLFL AAAIIDNVVI ---------- ---------- ---------- ---------- ---------- ---------- GGGNPAIPPL PVDIISSAAQ QTLWIFFFMD DGKTTRFFDD KPFQIIYKVI QQQVV----- GGGEPAVPPL PVDIISSNNS SRLWVFFFMD DGKTTRFFDD HPRQVVYKTI QQQVV----- ---------- --------AA GHHKKLLGGG GGAPPMMISS SRRDDGRRRY VVVTNNSLYT ---------- --------SS GAAEEAAGGG GGAPPMMVSS SRRDDGRRRY IIITNNSLYS ---------- --------NN GRRTTFFGGG GGGPPMMISS SRRDDGRRRY WWWTNNSLYT ---------- --------NN GKKAAFFAAA AAGPPMMISS SRRDDGRRRY WWWTNNSLYT ---------- --------NN GKKTTFFYYY YYGPPMMISS SRRDDGKKRY WWWTNNSLYT ---------- -----AAAKK NGGAALLGGG GGGPPMMISS SRRDDGRRRY FFFTNNSLYA ---------- -----AAATT SAAEELLGGG GGGPPMMISS SRRDDGRRRY FFFTNNSLYA ---------- --------AA SGGPPLLGGG GGGPPMMVSS SRRDDGRRRY FFFSNNSLYS EE-DQTTCCC QPPPLVVVKK GKKRRIIGGG GGGPPMMLSS SLLDDGKKRY AAATTTSLYD EE-DQTTCCC QPPPLVVVKK GKKRRVVGGG GGGPPMMLSS SLLDDGKKRY VVVTTTSLYA EE-DQKKSSS QPPPLVVVKK GKKKKVVGGG GGGPPMMLSS SLLDDGKKRY VVVTTTSLYA DD-DQDDSSS QPPPLVVVKK GKKQQVVGGG GGGPPMMLSS SLLDDGKKRY VVVTTTSLYA EE-DQKKSSS QPPPLVVVKK GKKRRVVGGG GGGPPMMLSS SLLDDGKKRY IIITTTSLYA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EE-DEKKSSS QPPPLVVVKK GKKRRVVGGG GGGPPMMLSS SLLDDGKKRY IIITTTSLYA EE-DQKKSSS QPPPLVVVKK GKKRRVVGGG GGGPPMMLSS SLLDDGKKRY VVVTTTSLYD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EE-DKEECCC QPPPVVVVKK GKKKKVVGGG GGGPPMMLSS SLLDDGKKRY VVVTNNSLYK EE-DKEECCC QPPPVVVVKK GKKIIIIGGG GGGPPMMLSS SLLDDGKKRY VVVTSSSLYI GG-EDTTWWW QVVVPIIIQQ GQQKKLLGGG GGGPPMMLTT TLLDDGKKRY VVVTNNSLFA KK-DDTTWWW QVVVPIIIQQ GKKKKLLGGG GGGPPMMLSS SLLDDGKKRY VVVTNNSLFA GG-EDSSFFF QVVVPIIIKK GKKSSLLGGG GGGPPMMLSS SLLDDGKKRY AAATNNSLFA GG-EDTTFFF QVVVPIIIKK GKKSSLLGGG GGGPPMMLSS SLLDDGKKRY AAATNNSLFA TT-EDEEEEE QVVVPVVVKK GHHRRLLGGG GGGPPMMLSS SLLDDGKKRY VVVTNNSLFR EE-GE----- PAAALVVVKK GRRKKIIGGG GGGPPMMLSS SLLDDGKKRY VVVTTTSLYK EE-ED----- EAAALVVVKK GRRQQIIGGG GGGPPMMLSS SLLDDGKKRY VVVSTTSLYK ---------- ---------- -------GGG GGGPPKKLSS SVVDDGKKRY VVVTNNSFYT NN-DPKKEEE APPPVLLLKK GRRRRLLGGG GGGPPMMLSS SLLDDGRRRY VVVSSSSLFP KKEDKKKEEE RAAARVVVKK GRRRRLLGGG GGGPPMMLSS SLLDDGKKRY VVVSSSSLYP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMQSS SWWDDGKKRY FFFSSSSLLN ---------- ---------- ---------- -----MMSSS SWWDDGQQRY YYYTSSSLLN TDNQFYYYGL GWWMVVVKKL AANN--SSLL DKFFVDFE-- -----ASQLG GDAASYC--- SNNQFYYYGL GWWMAAAKKV VVNN--EELL EKFFVDFR-- -----AAQLG GDAASFC--- TDDQFYYYGV AAAQVVVLLA AAGG--DDLL ADWWVEFD-- -----YAQLG GDCCSFCSVK TDDQFYYYGV GVVEVVVMMA VVGG--NNLL DKFFVSFD-- -----YAQLG GDCCSFCSV- TDEQFYYYDR AAAMVVVMMA VVGG--NNLL DKWWVDFA-- -----YSQLG GDCCSFCSV- ADPQFYYYGI GWWMVVVKKL AAGG--NNII DPFFLEWK-- -----HPQLG GDCCSYC--- ADEQFYYYGI GWWMVVVKKV VVNN--DDMM DPFFVDFE-- -----QVQLG GDAASYC--- SDEQFYYYGI GWWIAAAKKA AADD--GGLL DPFFTEVD-- -----LPQLG GDSSSYCS-- DDKQFYYYDL REEGSSSVVM QQVVDTNNLL NPLLVDFKPP LGGGPAAEYG GDCCSWI--- ADKQFYYYNL REEGSSSVVM QQIIDTNNLL NPLLVDFKPP LGGGPAAEYG GDCCSWI--- ADKQFYYYDL REEGSSSVVM QQIIDTKKLL NPLLVDFKPP LGGGPAAEYG GDCCSWL--- ADKQFYYYDL REEGSSSVVM QQIIDTKKLL NPLLVDFKPP LGGGPAAEYG GDCCSWL--- ADKQFYYYDL REEGSSSVVM QQVVDTKKLL NPLLVDFKPP LGGGPAAEYG GDCCSWI--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ADKQFYYYDL REEGSSSVVM QQVVDTKKLL NPLLVDFKPP LGGGPAAEYG GDCCSWI--- DDKQFYYYDL REEGSSSVVM QQIIDTKKLL NPLLVDFKPP LGGGPAAEYG GDCCTWL--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KDKQFYYYDM KEEGSSSVVM QQIIDTKKLL NPLLVDFKPP GGGGPVAEYG GDCCSWV--- IDKQFYYYDL KEEGAAAVVM QQIIDTKKLL NPLLVDFKPP DGGGPVAEYG GDCCTWI--- ADKQFYYYGL EKKGSSSHHI QQIIDTKKLL NPFFVDFAPP DGGGPAAEYG GDCCTWI--- ADKQFYYYKL EQQGSSSHHI QQIIDTNNLL NPFFVDFAPP DGGGPSAEYG GDCCTWI--- ADRQFYYYEL DKKGSSSHHI QQIIDTKKLL NPFFVDFDPP EGGGPAAEYG GDCCTWI--- AVVSFYYYEI EKKGSSSHHI QQIIDTKKLL NPFFVDFDPP DGGGPSAEYG GDCCTWI--- RDEQFYYYDL KKKGSSSHHM QQIIDTKKLL NPFFVDFAPP EGGGPSAEYG GDCCTWI--- KDDQFYYYEH KSSGAAATTM QQVVNPSSMM NRLLIDFKEE GGGGPYAEYG GDCCTWI--- KDDQFYYYEN RSSGAAATTM QQIIDPTTMM NKLLIDFKPP GGGGPYAEYG GDCCTWI--- TDKQFYYYNV KEEGSSSVVM QQIIDTKKLL NKLLVDFKPP NGGGPCADFC GDSSTLA--- PDKQFYYYEM AAAGGGGTTI QQLLDVNNMM NELLVDFGPP YGGGPGPE-- ---------- PDKQFYYYKM SQQGGGGHHI LLIIDTNNII NELLVDFNPP YGGGPSPEYG GDCCTWLDA- ---------- ---------- ---------- ---------- ---------- ---------- ND-------- KKKGKKKDDD QQYYLYWWKK VEAAVDFEGG LGGG--AIFS SALLY----- ND-------- KKKGKKKDDD QQFFLYWWKK KEAAIDFAKK LGGG--PQFA RALLYAGNRL ------- ------- KK----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLARRRE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NKAKKKKQPP PTTAVPTGGL LTTTTTAARR LLDGGAQQSL PPTTALLLLL LLTTTPRYYA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -------MMR gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ATFAIIQQVS SSPRESSRKK TTTRVGLEES AVVQVVPPQA AVWWAAHPPK LLIIIAAPAR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------EEA LLQQQSSVAQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MKKE QQPPPWWFLS ---------- ---------- ---------- ---------- --LLLLKGGL NNTTTEELHT ---------- ---------- ---------- ---------- ---------- ---------- SPTPLLNNNP PTPHNPPPAA SSSPHRVLLR VRRRIINNPP PLCCPPPHHL MMEEEGGAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMAAATTVLD ---------- ---------- ---------- ---------- ---------- MMGGGTTVLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------RRE ---------- ---------- ---------- ---------- ---------- -------RRI MMHHHFFALR --------MA AIIVVPPFKR DPPTTPPPPP KKKMMAMLLA YVACTGGGNR ADDFIIVVDN ---------- -MMAAKKLKP DPPTTPPPPP RRRDDAMIIA YVAAVGGGNA PDDFLLVVDD ---------- ---MMSSMRP DPPTTAPPPP EEELLAMFFA YTLLPDDS-R PDDALLVVDK ---------- ---MMTTMRP DPPTTAPPPP KKKLLAMFFA YTLLPDDS-K PDDALLVVDK ---------- ---MMTTLRP DPPTTPAAAA KKKLLAMLLA FTLMPDDS-K PDDGLLVVDD ---------- -MMAATTWKP DPPSSPPPPP RRRLLAAIIA YVAMPEEK-Q PDDAIIVVDD ---------- -MMVVTTWRP DPPTTPPPPP RRRMMAVLLA YVVRPMMN-K PDDAMMVVDD ---------- -MMAASSWRP DPPTTPPPPP KKKMMAMLLG YVALPGGE-R PDDALLVVDD --------TK KCCTTKK--C GPPGGTLLLL EEEAAMKIIV YLPCRNNGEA PDDYLLTTDD ---------- ---------- ---------- ------MIIV YLPCRNNGEA PDDYLLTTDD RRLPPG--TQ QCCGGKK--C GPPGGSLLLL EEEAAMKIIV YLPCGNNGEA PDDYLLTTDD ---------- ---------- ---------- -----MKIII YLPCRNNGEA PDDYLLTTDD --------TK KCCGGNN--C GPPGGTLLLL EEEAAMKIIV YLPCRNNGEA PDDYLLTTDD QQRPPIAATK KCCGGNN--C GPPGGTLLLL EEEAAMKIIV YLPCRNNGEA PDDYLLTTDD --------TK KCCGGNN--C GPPGGTLLLL EEEAAMK--- --------EA PDDYLLTTDD --------TK KCCGGNN--C GPPGGTLLLL EEEAAMKIIV YLPCRNNGEA PDDYLLTTDD SSLWWQEETK KCCGGDD--C GPPGGTQQQQ EEEAAMKIIV YLPCRNNGEA PDDYLLTTDD TTTLLVFFTK KCCGGNN--C GPPGGTLLLL EEEAAMKIIV YLPCRNNGEA PDDYLLTTDD --------TK KCCGGNN--C GPPGGTLLLL EEEAAMKIIV YLPCRNNGEA PDDYLLTTDD AATAAAAAKT TCCCCHHTAK GPPGGTLLLL EEEAAMELLV YVTCNGGGNK LDDYLLTTDD ---------- ---------- ---------- ---------- ---------- ---------- --------AK KCCGGSS--C GPPGGSLLLL DDDAAMKIIV YLPCRSSGNK PDDYLLTTDD DDVVVNEE-V VNNGGCCCKS GPPGGSIIII EEESSMSLLI YVTAAGGGEK PDDYLLTTDD QQVVVSEENQ QQQGGCCCKS GPPGGSLLLL EEEAAMSLLI YVTAAGGGEK PDDYLLTTDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -RRMMLLQVG GPPGGTLLLL AAAAAMSLLI YVTATGGGDK PDDYLLTTDD --MAAAAAAA ACCCCGGGAT GPPGGTLLLL EEEAAMELLL YVTCNGGGNK PDDYLLTTDD ---MMSPPLK KCCHHGG--- GPPGGSAAAA DDDAAIKVVL FVTA---ADG PDDAIITTDN ---MMP--LK KCCHHGG--- GPPGGSAAAA DDDAAIKVVL FVTA---ADG PDDAIITTNN ---------- ---------- ---------- ---------- ---------- ---------- --------MS SEESSKKCKC GPPGGTLLLL DDDAAVRLLL YVVCPNNDEH GDDYLLTTDD ---------- ---------- ---------- -----MRLLL YTVTPNNDPH GDDYLLTTDD ---------- ---------- MPPGGT---- DDDIILILLY FSNWGDDRYD ITTDRRNNRV --AAAG--MG GLLPPFFRAF ADDEEQPPPP YYYMMPKFFV YVWTVEEMDE QDDKLLTTDR RRVSSGLLLA AAAPPAAGVR ADDEEAPPPP YYYMMKKYYV YVWTAEEVDE QDDKLLTTDN PSESSSIVVK KEELYYYYIN DEELHFWNAA L--PPPNNGK IIERRRRRRR FLIPGGLLSS PSPGGGVIIK KDDLYYYYIG DEELHFWNAA Y--PPPNNAK LLERRRRRRR YLIPAALLSS PSSGGGIVVT TTTMNNNNTG DEEFHFWNAA L--PPPLLTH LLERRRRRRR FLIPGGLLSS PSPGGGIVVT TTTMNNNNKG DEEFHFWNAA L--PPPLLAH IIERRRRRRR YLIPGGLLSS PSEGGGIVVQ QIIMNNNNKG DEEFHFWNAA L--PPPLLTH LLERRRRRRR YLIPGGIISS PSPAAAIVVQ QAAMHHHHAG DEELHFWNAA L--PPPNNAH MMERRRRRRR YLVPGGLLSS SSSGGGVVVV VDDMYYYYTG GEELHFWNAA L--PPPNNAH VVERRRRRRR YLVPDDIISS PSGAAAIVVR REEMNNNNAA DEELHFWNAA L--PPPYYAH VVERRRRRRR YLIPGGIISS PSPSSSVIIR RPPMYYYYLK DEELHSWNTT --------FD KKSRRRRNNN KLIPGGLLSS PSPSSSVIIR RPPMHHHHLK DEELHSWNTT --------FD KKSRRRRDDD KLIPSSIISS PSPCCCVIIR RPPMNNNNLR DEELHSWNAA --------FD KKSRRRRTTT KLMPCCLLSS PSPCCCVIIR RPPMHHHHLK DEELHSWNTT --------YD KKARRRRTTT KLVPAALLSS PSPCCCVIIR RPPMNNNNLK DEELHSWNTT --------FD KKSRRRRTTT KLVPSSLLSS PSPCCCVII- ---------- ---------- ---------- ---------- ---------- PSPCCCVIIR RPPMNNNNLK DEELHSWNTT --------FD KKSRRRRTTT KLVPSSLLSS PSPCCCVIIR RPPMNNNNLK DEELHSWNTT --------FD KKSRRRRTTT KLVPSSLLSS PSPSSSVIIR RPPMYYYYLK DEELHSWNTT --------FD KKSRRRRNNN KLVPSSFFSS PSPCCCVIIR RPPMNNNNLK DEELHSWNTT --------FD KKSRRRRTTT KLVPSSLL-- PSPCCCVIIR RPPMNNNNLK DEELHSWNTT --------FD KKSRRRRTTT KLVPSSLLSS PSPSSSVIIR RPPVHHHHIG DKKLHSWNSS --------HD AAKRRRRRRR FLIPSSLLSS ---------- ---MNNNNTN DEELHSWNTT --------YD KKVRRRRNNN KLIPCCLLSS PSPSSSVIIR RPPMNNNNVN DEELHSWNTT --------YD KKVRRRRNNN KLIPCCLLSS PSPSSSVIIR RPPVYYYYVG DEELHTWNSS --------HD AAERRRRRRR FLIPSSLLSS PSPSSSVIIR RPPVYYYYVG DEELHTWNSS --------HD AAQRRRRRRR FLIPGGIISS ---------- ---MFFFFVG DEELHSWNSS --------HD AADRRRRRRR YLVPSSLLSS PSPSSSVIIR RPPMFFFFVG DEELHSWNSS --------HD VVDRRRRRRR YLVPSSLLSS PSPSSSVIIR RPPVHHHHVG DEELHSWNAA --------HD AASRRRRRRR FLIPSSLLSS PSDCCCVIIR RDDVHHHHIG DEEVHTWNAA --------HK EEKRRRRSSS HLIPCCLLSS PSECCCIIIR RDDVNNNNIG DEEVHTWNAA --------HK EEKRRRRSSS HLIPCCLLSS ---------- ---------- ---------- ---------- ---------- -MVRKKLLSS PSPCCCVIIR RYYTSSSSKH NEELHSWNTT HVVPPP--GK PPTRRRRDDD RLVPCCLLSS PSPCCCIVVR RFFTRRRRKG DEELHSWNAA YVVDDDEESK PPKRRRRDDD RLVPSSLLSS GVFGGGVLLD DPPVVVVVLE DKKELSPTPP ---------K QQGGGGGPPP QMLLSSLLGG PSAGGGVIIS SSSVGGGG-R NEEAHGFSAA ---------- --DRRRRRRR FFWGGGLLTT PSPGGGVVVT TSSVGGGG-R NEEAHSFTDD ---------- --DRRRRRRR YLWGGGLLTT SRRIIITTTK PPNNPRRPPP PKVVIEEVKV VGYYYYSSLH TVCCPIIYII ISSSLGGEEE SRRIIITTTK PPDDKRRPPP PKIIVEVAVR RGYYYYTTYH TVCCPIIYII ISSSLGGDDD SRRIIVTTTK PPHHPTTAAA AKIIIEEILK KGYYYYSSPH TVCCPIIYVV VSSSLGGDDD SRRIIITTTK PPDDPTTAAA AKIIIEEVFK KGYYYYSSPH TICCPIIYVV VSSSLGGDDD SRRIIIVVVK --EEPLLAAA AKIIIEEVFK KGYYYYSSPH TICCPIIYVV VSSSLGGDDD SRRIIITTTK PPDDPLLPPP PKVVIETLAR RGYYYYSSPH TVCCPIIYVV VTTTLGGEEE SHHIIITTTK PPDDPTTPPP PKVVIDELAR RGYYYYAAPH TVCCPIIYII ISSSLGGEEE SRRIIITTTK PPDDPRRPPP PKVVIEELHR RGYYYYSSPH TICCPVVYVV VSSSLGGEEE SRRIIVVVVG SSEEPRRPPP PKVVIEEIQK KNVVVVSSTH TSCCAEEVMM MVVVTLLLLL SRRIIVVVVG SSEEPRRPPP PKVVIEEIHK KNLLLLGGLH TSCCAEEVMM MIIISLLPPP SRRIIVVVVG SSDDPRRPPP PKVVIEDIHK KGLLLLGGVH TSCCAEEVMM MIIITLLSSS SRRIIVVVVG TTEEPRRPPP PKVVIEDIHK KNLLLLGGFH TSCCPEEVMM MVVVTLLPPP SRRIIVVVVG SSEEPRRPPP PKVVIEDIHK KELLLLAALH TSCCAEEVMM MIIISLLVVV ---------- ---------- ------DIHK KELLLLAALH TSCCAEEVMM MIIISLLVVV SRRIIVVVVG SSEEPRRPPP PKVVIEDIHK KELLLLAALH TSCCAEEVMM MIIISLLVVV SRRIIVVVVG SSEEPRRPPP PKVVIEDIHK KELLLLAALH TSCCAEEVMM MIIISLLVVV SRRIIVVVVG TTEEPRRPPP PKVVIEDIHK KGLLLLGGPH TSCCPEEVMM MIIITLLPPP ---------- ---------- ---------- ---------- ---------- ---------- SRRIIVVVVG SSEEPRRPPP PKVVIEDIHK KELLLLAALH TSCCAEEVMM MIIISLLVVV GRRVVVTTTA TTDDPRRPPP PKVVVEDIAN NGLLLLGGPH TSCCADDIMM MIIICLLKKK SRRIIVVVVG TTDDPRRPPP PKTTVEEVFK KGLLLLAALH TSCCGEEIMM MIIISIIPPP SRRIIVVVVG SSDDPRRPPP PKTTVEEVFK KGLLLLAAPH TSCCGEEIMM MIIISLLPPP GRRIIVTTTK TTNNPRRPPP PKVVVDDIIK KGLLLLAAPH TSCCAEELMM MIIICLLKKK GRRVVVTTTK TTNNPRRPPP PKVVVEDISK KGLLLLAAPH TSCCAEEIMM MIIICIIKKK GRRIIATTTK EENNPRRPPP PKYYVDEIAK KGLLLLAAPH TACCAEEILL LVVVCLLEEE GRRIIATTTK EENNPRRPPP PKYYVDEIAK KGLLLLAAPH TACCTEEILL LVVVCLLEEE GRRVVVTTTL KKDDPRRPPP PKVVVEDIAK KGLLLLGGPH TSCCAEEIMM MIIICLLKKK DRRIIIVVVE NNEE-RRIII IHTTIEKLHL L-LLLLSSPH TSCCANNIMM MIIITLLAAA DRRIIVVVVE NNEE-RRIII IHTTIEKLHL L-LLLLSSPH TSCCANNIMM MIIITLLAAA GVVEEKVVVG GG-------- ---------- ---------- ---------- ---------- DRRIIVTTTG TTDDPRRPPP PKVVIEDVLG GDCCCCTTPH TTCCPNNIMM MIIIIMMAAA DFFIIIVVVV TTDDPRRPPP PKTTIDDVLS SNVVVVTTPH TTCCANNIMM MIIIVMMAAA KRRLLVSSSL YYSSAWWKKK KP----DLIF FVLLLLAASH TAYYPAALKK KQQQGVVSSS NRRIIIVVVH SSDDPSSPPP PKTTIDFVKS SGVVVVVVPH TFAAPMMMII ITTTLSSDDD SKKIIVVVVH SSDDPAAPPP PKTTITFVES SGVVVVVVPH TLAAPMMLII ITTTLSSKKK ---GGIMLDH HSFLLGKWWI DGDDQY---- ---------- --AYWWL-PP NEVLSSSSSS RRRGGILLDH HTFIIGRWWV YGPPQY---- ---------- --AYWWL-PP SGVMSSSSSS TTTGPIIMDC CTFLLGRWWI DGPPQD---- ---------- --HYWWL-PP RDYMSSSSSS TTTGPVIMDC CTFLLGRWWI DGPPQT---- ---------- --HYWWL-PP RDYMSSSSSS TTTGPIILDC CTFLLGRYYM DGEEQT---- ---------- --HYWWL-PP RDYMSSSSSS ---GGIMLDA ASFLLGRWWV EGPPQY---- ---------- --AYWWL-GG YDTLSSSSSS ---GGIILDH HNLLLGRWWI DGDDQY---- ---------- --HYWWL-GG YDTLSSSSSS ---GGVVMDH HSFLLGRWWV EGPPQQ---- ---------- --AYWWL-GG YDTMSSSSSS GGGGGFLLDG GTFKKGTWWK PGAASP---- ---------- --GYWYP-RR HNVMTTTTTT GGGGGFLLDG GTFKKGTWWK PGEEAP---- ---------- --GYWYP-RR HNIMTTTTTT GGGGGFLLDG GTFKKGTWWQ PGAAAP---- ---------- --GYWYP-RR HNVMTTTTTT GGGGGFLLDG GTFKKGTWWQ PGAAAP---- ---------- --GYWYP-RR HNVMTTTTTT GGGGGFLLDG GTFKKGTWWR PGAAAP---- ---------- --GYWYP-RR HNVMTTTTTT GGGGGFLLDG GTFKKGTWWR PGAAAP---- ---------- --GYWYP-RR HNVMTTTTTT GGGGGFLLDG GTFKKGTWWR PGAAAP---- ---------- --GYWYP-RR HNVMTTTTTT GGGGGFLLDG GTFKKGTWWR PGAAAP---- ---------- --GYWYP-RR HNVMTTTTTT GGGGGFLLDG GTFKKGTWWR PGSSAP---- ---------- --GYWYP-RR HNVMTTTTTT ---------- ---------- ---------- ---------- ---------- ---------- GGGGDSVLLP PRLSSG---- ---------- ---------- ---------- ----AAAAAA GGGAGGLLLD DEFKKGRGGN RFPPIS---- ---------- --ERLYNYAA WGLFWWWWWW GGGGGFLLDG GTFKKGNWWA EEAAAP---- ---------- --GYWYP-RR HNVMTTTTTT GGGGGFLLDG GTFKKGNWWV EESSAQ---- ---------- --GYWYP-RR HNVMTTTTTT GGGAGGLLLD DDFKKGRWWK PHSSPL---- ---------- --GYWYP-RR HNTMTTTTTT GGGAGGLLLD DEFKKGRWWK PHSSPL---- ---------- --GYWYP-RR HNTMTTTTTT GGGAGGLLLD DDFKKNRWWK PHSSPL---- ---------- --GYWYP-RR HKTMTTTTTT GGGAGGLLLD DDFKKNRWWK PISSPL---- ---------- --GYWYP-RR HKTMTTTTTT GGGAGGLLLD DEFKKGRWWK PHSSPL---- ---------- --GYWYP-RR HKTMSSSSSS GGGPGFLLDG GTFKKGTWWA DKTTVP---- ---------- --NYWYP-RR RNVMTTTTTT GGGPGFLLDG GTFKKGTWWA DKVVVP---- ---------- --NYWYP-RR RNIMTTTTTT ---------- ---------- ---------- ---------- ---------- ----IIIIII GGGAGDVEFD DNFVVGTWWR GRKKAL---- ---------- --GYWYP-HH FNVMSSSSSS GGGAGDILFD DDFIIGTWWK GKKKAL---- ---------- --GYWYP-YY FDVMSSSSSS SSSPLGQTSK KENSSAKGGA SFEEEI---- ---------- --QLHNG--- REKSDDDDDD HHHGTLEYND DGEAATYWWP TDDDMQGAVV VAGGGAAADG GGGYRAI-RR KNVMSSSSSS HHHGTLEYTN NGEAATHWWP TGDDLRGAII IKGGGKKADG GGDYRAP-RR KNLLSSSSSS WWAAPP--IE GG--LLHLLK YGNNNNRIIF DDRRKRRRRH HHSLLLENNN RMMMML---- WWTTPP--FE GG--FFCLLK YGNNNNKLLV DDAAKRRHHY YYAILLEHHH RMMMML---- WWAAPP--FE GG--IIDLLL YGHHHHRLLF DDRRARRNNQ QQTILLQHHH QMMMML---- WWAAPP--FE GG--IIDLLL YGHHHHRLLF DDRRARRNNQ QQTILLNHHH QMMMML---- WWGGPP--FE GG--IIDLLL YGHHHHKIIF KKRRDRRNNQ QQTILLNHHH QMMMML---- WWGGPP--VE GG--LLILLL YGRRRRRLLF DDTTRRRHHQ QQEIFFEHHH QLLLLF---- WWGGPP--VE GG--VVELLL YGHHHHRLLV DDYYRRRHHQ QQTLLLEYYY QMMMML---- WWGGPP--IE GG--LLILLL YGRRRRRLLI DDRRRRRHHQ QQALVVEHHH QMMMML---- WWAAPP--FK GGFFNNVEEA YGSSSSRIIV DDQQRHHIIQ QQTLMM-DDD GLLLLP---- WWAAPP--FK GGFFNNVEEA YGSSSSHIIV DDQQRHHIIQ QQTLMM-DDD GLLLLP---- WWAAPP--FR GGFFNNVEEA YGSSSSHLLV DDQQRHHIIQ QQTLLL-DDD GLLLLP---- WWAAPP--LR GGFFNNVKKA YGSSSSHLLV DDQQRRRIIQ QQTLLL-DDD GLLLLP---- WWAAPP--LR GGFFNNVEEA YGSSSSHLLV DDQQHHHIIQ QQTLLL-DDD GLLLLP---- WWAAPP--LR GGFFNNVEEA YGSSSSHLLV DDQQRHHIIQ QQTLLL-DDD GLLLLP---- WWAAPP--LR GGFFNNVEEA YGSSSSHLLV DDQQRHHIIQ QQTLLL-DDD GLLLLP---- WWAAPP--LR GGFFNNVEEA YGSSSSHLLV DDQQRHHIIQ QQTLLL-DDD GLLLLP---- WWAAPP--VQ GGFFNNVEEA YGKKKKHLLV DDQQRHHIIQ QQTLMM-DDD GHHHHP---- ---------- ---------- ---------- ---------- ---------- ---------- SSAASS--RL GGSSRRASSA VAGGGGITT- ---------- ---------- ---------- QQCCSS--YT GGAAEELTTA VHVVVVISSL NNIIMRRIIE EESLLL-DDD QAAAAANNII WWGGPP--FA GGFFKKVQQA YGHHHHSLLV DDTTEHHRRQ QQTILL-DDD GLLLLP---- WWGGPP--FA GGFFKKVQQA YGHHHHSLLV DDTTEHHLLQ QQTILL-DDD GLLLLP---- WWGGPP--FT GGFFDDVAAD YGRRRRHLLC QQAARGGLLQ QQTLLL-TTT GLLLLP---- WWGGPP--FL GGFFNNVAAD YGRRRRHLLV SSPPGGGIIQ QQTLLL-KKK GLLLLP---- WWGGPP--FS GGFFDDVAAD YGSSSSHLLV SSPPGGGMMQ QQLILL-TTT GLLLLP---- WWGGPP--FS GGFFNNVAAD YGSSSSHLLV SSPPGGGIIQ QQLILL-TTT GLLLLP---- WWGGPP--FR GGFFDDVQQD YGRRRRHLLV DDPPGGGLLQ QQTLLL-TTT GLLLLP---- WWGGPP--IK GGFFNNVGGE YGNNNNSVVI EEDDSKKYYQ QQTILLPLLL GAAAAP---- WWGGPP--IK GGFFNNVPPE YGNNNNSVVI EEDDTKKHHQ QQTILLPRRR GAAAAP---- RRGGPP--VC DDEEEEQPPE VIKKKKCKKV ---------- ---------- ---------- WWGGPP--FR GGYYHHCDDD YGCCCCRLLF RRQQERRLLQ QQTILL-DDD GLLLLP---- WWGGPP--WR GGWWKKLEED YGCCCCRLLF KKSSTQQLLQ QQTILL-DDD GIIIIP---- PPDDPP--AF SSSSEEKKKT KPQQQQHVVE LL-------- ---------- ---------- FFTTWWNYMD GGQQMMAEEA FGNNNNTIIQ DDHHTRRPPK KKVFVVAPPP ---------- FFTTWWNYMD GGKKMMPEEA FGNNNNTVVT DDHHTKKPPK KKVFVVAPPP ---------- EEELRLHHDL MINNMVVSLL LLKKDDSSIW LWWWFF--ED DKWAAEEVPA EEPPPLLLLL EEEVRLHHDL MVNNVLLNTT TTKKDDSSIW LWWWFF--ED DKWAAEEVEA QQPPPFFLLL EEEVRAHHDE YVGGVVVDTT TTTTNNGSIW TWWWWW--EG GKFVVKKTPA EEPPPAALLL EEEVRAHHDE YVGGVVVDTT TTTTNNASIW TWWWWW--EG GKFAAEETPP EEPPPAALLL EEEIRAHHDD YCGGVVVDTT TTTTNNGAIF TWWWWWKKDD DTFAAKKTDP VVPPPAALLL EEELRAHHDA YVNNCIISLL LLKKDDSSIW TWWWYY--DK KKWVVRRVPA EEAAAAALLL EEELRAHHDA YMNNCVVSLL LLKKDDASIW LWWWYY--DN NSWLLKKVPA EEPPPAALLL EEELRAHHDT YVGGVVVSLL LLEEDDASVW LWWWHH--QN NSWIIRRVPA EEPPPAALLL EEEIRLHHDT QVGGCLLSSS SSNNIIFYKN EEEEGG---- --------VE KKVVVIIKKK EEEIRLHHDT QVGGCLLSSS SSNNIIFYKN EGGGGG---- --------VE KKVVVIIKKK EEEIRLHHNA QVGGCLLSSS SSTTIIFYKN QGGGGG---- --------VE KKVVVIIKKK EEEIRLHHNA QVGGCLLSSS SSTTIIFFKN EDDDGG---- --------AQ KKVVVIIKKK EEEIRLHHNA QVGGCLLSSS SSTTIIFYKN EGGGGG---- --------VE KKVVVIIKKK EEEIRLHHNA QVGGCLLSSS SSTTIIFYKN EGGGGG---- --------VE KKVVVIIKKK EEEIRLHHNA QVGGCLLSSS SSTTIIFYKN EGGGGG---- --------VE KKVVVIIKKK EEEIRLHHNA QVGGCLLSSS SSTTIIFYKN EGGGGG---- --------VE KKVVVIIKKK EEEIRLHHDS QVGGCLLSSS SSTTIIFYKN EGGGGG---- --------VE KKVVVIIKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CCCLRIHHWN QDVVVVVSFF FFSSGGGSDP DAAAYY---- --------LK RRKKKLLAAA EEEIRLHHDA QVGGCLLSSS SSTTVVFYKE KDDDGG---- --------AE KKVVVIIKKK EEEIRLHHND QVGGCLLSSS SSSSIIFYKE KDDDGG---- --------AE KKVVVIIKKK EEEIRLHHDD TVGGSLLSSS SSNNMMFFKT QDDDGG---- --------HE LLAAAIILLL EEEIRLHHDD TVGGSLLTSS SSNNMMFFKT QDDDGG---- --------HE IIVVVIILLL EEEIRLHHDD TVGGSLLSSS SSNNMMFFKN SDDDDD---- --------YE IIVVVIILLL EEEIRLHHDD TVGGSLLSSS SSNNMMFFKN SDDDEE---- --------HE VVVVVIILLL EEEVRLHHDD TVGGCLLTSS SSNNMMFFKT ADDDGG---- --------HE VVAAAIILLL EEEVRLHHEE HVGGCLLGSS SSGGIIIHPV EEEENN---- --------AT LLVVVAAKKK EEEVRLHHEE HVGGCLLGSS SSAAIIIHPD EKKKNN---- --------AS LLVVVAAKKK ---------- ---------- ---------- ---------- ---------- ---------- EEEIRLHHNN QVGGCFFXXX XXXXXXXX-- ---------- ---------- ---------- EEEIRLHHNA EVGGCLLNAA AAKKVVFKKK SDDDSS---- -------FKV IIDDDIIVVV ---------- ---------- ---------- ---------- ---------- ---------- EEEIRPWWGN YSTTTLLTSS SSQQLLIYED DAAAGG---- ---------- -------KKK EEEIRAWWGN YTSSTLLTSS SSQQLLIYED GEEEGG---- ---------- -------KKK PIILLKKPPF VLLVVTDIDD ILLDDKFLWW GGGEQYSKVV VLLLLLLTTT GGKKKLLLGG PVVLLKKDDF VLLVVTDIDD ILLDDRFVWW GGGEQYTQRR RLLLLLLAAA GGKKKIIIGG PLLLLQQGGF VLLVVTDIDD LLLDDRFVWW GGGEQYSNVV VLLLLLLAAA GGRRRIIIGG PLLLLQQGGF VLLVVTDIDD LMMDDRFVWW GGGEQYSKKK KLLLLLLAAA GGHHHIIIGG PLLLLKKGGF CLLVVTDIDD LLLDDKYVWW GGGEQYSNVV VLLLLLLTTT GGEEEIIIGG PVVLLKKGGF VLLVVTDIDD LMMDDRFVWW GGGDQYSEKK KLLLLLLTTT GGRRRIIIGG PIILLKKPPF VLLVVTDINN LVVDDRFVWW GGGEQYSNRR RLLLLLLTTT GGQQQIIIGG PLLLLKKDDF VLLVVTDINN LLLDDRFVWW GGGEQYSNRR RHHHHHHTTT GGRRRLLLGG KKKGGWWMML MLLIITDILL LLLDDRFFWW LGGDQYSKRR RLLLLLLTTT GGFFFLLLGG KKKGGWWMML MLLIITDILL LLLDDRFFWW LGGDQYSKRR RLLLLLLTTT GGFFFLLLGG KKKGGWWMML MLLIITDILL LLLDDRFFWW LGGDQYSRRR RLLLLLLTTT GGFFFLLLGG KKKGGWWMML MLLIITDILL LLLDDHFFWW LGGDQYSRRR RLLLLLLTTT GGFFFLLLGG KKKGGWWLLL MLLIITDILL LLLDDRFFWW LGGDQYSRRR RLLLLLLTTT GGFFFLLLGG KKKGGWWLLL MLLIITDILL LLLDDRFFWW LGGDQYSRRR RLLLLLL--- ---------- KKKGGWWLLL MLLIIT---- ---------- ---------- ---------- ---------- KKKGGWWLLL MLLIITDILL LLLDDRFFWW LGGDQYSRRR RLLLLLLTTT GGFFFLLLGG KKKGGWWMML MLLIITDILL LLLDDRFFWW LGGDQYSRRR RLLLLLLVVV GGFFFLLLGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VAAKKFFGGV LEEFFPPAWW IFFDDLLF-- ---------- ---------- ---------- KEEGGWWAAL MLLIITDILL ILLDDRFFWW LGGDQYTNKK KLLLLLLVVV GGFFFLLLGG KEEGGWWPPM MLLIITDILL ILLDDRFFWW LGGDQYTNKK KLLLLLLVVV GGFFFLLLGG KQQNNWWIIL MLLIITDFLL ILLDDRFFWW LGGDQYENVV VLLLLLLTTT GGWWWVVVGG KQQNNWWFFL MLLIITDFLL ILLDDRFFWW LGGDQYENKK KLLLLLLTTT GGWWWAAAGG KEENNWWIIL MLLIITDFLL ILLDDRFFWW LGGDQYENVV VLLLLLLTTT GGWWWVVVGG KEENNWWIIL MLLIITDFLL ILLDDRFFWW LGGDQYENVV VLLLLLLTTT GGWWWVVVGG KRRNNWWIIL MLLIITDFVV ILLDDRYLWW LGGDQYEKVV VLLLLLLAAA GGWWWAAAGG KSSGGWWAAL MLLIITDILL IMMDDRFVWW LGGDQYSKKK KLLLLLLNNN SSYYYIIIGG KEENNWWAAL MLLIITDILL IMMDDRFVWW LGGDQYSNKK KLLLLLLNNN SSFFFIIIGG ---------- ---------- ---------- ---------- ---------- ---------- QEENNGGEEI MMMMMTDILL ILLDDRYFWW RGGDQYSNRR RLLLLLLTTT GGFFFLLLGG DGGSSGGVVA MMMIISDIII ILLDDRFVWW RGGDQYTNKK KLLLLLLTTT GGFFFLLLGG ---------- ---------- ---------- ---------- ---------- ---------- AAADDIIGGN DLLPPVDISS IAADDQTIFF MGGKLFSKFF FQQQQQQIII YYVVVIIIDR AAADDIIGGE KLLPPVDISS INNDDSRVFF MGGKLFSHRR RQQQQQQVVV YYTTTIIIGA FHAAAA---- ---------- -------AGH KTTAPQQMEE IISRRTLLSS SSTWDDNNQY YHEEEE---- ---------- -------SGA ETTAPQQMSS VVSRRTLLSS SSSWNNNNQY ARAAAA---- ---------- -------NGR TAAGPQQMEE IISRRTLLSS SSTWDDDDQY ARTTTT---- ---------- -------NGK AAAGPQQMEE IISRRTLLSS SSTWDDDDQY VKTTTT---- ---------- -------NGK TGGGPQQMEE IISKRTLLSS SSTWDDEEQY VSAAAAGG-- ---------- ------AKNG ANNGPQQMEE IISRRTLLGG GGAVDDPPQY VRAAAA---- ---------- ------ATSA ENNGPQQMEE IISRRTLLRR RRAWDDEEQY VRAAAA---- ---------- -------ASG PNNGPQQMEE VVSRRSLLAA AASWDDEEQY IVGGGGQQVE EE-QLTCCQQ PPPLVVVKGK RPPGPQQMQQ LLSKRTLLSS SSDWDDKKQY IVGGGGQQVE EE-QLTCCQQ PPPLVVVKGK RPPGPQQMQQ LLSKRTLLSS SSAWDDKKQY IVGGGGQQVE EE-QLKSSQQ PPPLVVVKGK KPPGPQQMQQ LLSKRTLLSS SSAWDDKKQY IVDDDDQQVD DD-QLDSSQQ PPPLVVVKGK QAAGPQQMQQ LLSKRTLLSS SSAWDDKKQY IVGGGGQQVE EE-QLKSSQQ PPPLVVVKGK RAAGPQQMQQ LLSKRTLLSS SSAWDDKKQY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IVGGGGQQVE EE-ELKSSQQ PPPLVVVKGK RAAGPQQMQQ LLSKRTLLSS SSAWDDKKQY IVGGGGQQVE EE-QLKSSQQ PPPLVVVKGK RPPGPQQMQQ LLSKRTLLSS SSDWDDKKQY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ILGGGGTTVE EE-KLECCQQ PPPVIIVKGK KPPGPQQMQQ LLSKRTLLSS SSKWDDKKQY IQGGGGTTVE EE-KLECCQQ PPPVTTVKGK IPPGPQQMQQ LLSKRTLLSS SSIWDDKKQY IQGGGGAAAG GG-DKTWWQQ SSVPEEIQGQ KRRGPQQMQQ LLTKRTLLSS SSAWDDKKQY IQGGGGVVAK KK-DETWWQQ SSVPEEIQGK KRRGPQQMQQ LLSKRTLLSS SSAWDDKKQY LQGGGGKKAG GG-DNSFFQQ FFVPQQIKGK SRRGPQQMQQ LLSKRTLLSS SSAWDDRRQY LQGGGGKKAG GG-DNTFFQQ FFVPQQIKGK SRRGPQQMQQ LLSKRTLLSS SSAWVVVVSY LQGGGGVVYT TT-DKEEEQQ YYVPQQVKGH RRRGPQQMQQ LLSKRTLLSS SSRWDDEEQY VHEEEEKKVE EE-E----PP IIALYYVKGR KEEGPQQMQQ LLSKRTLLKK KKKWDDDDQY IHEEEEKKVE EE-DD---EE IIALYYVKGR QEEGPQQMQQ LLSKRSLLKK KKKWDDDDQY ---------- ---------- ---------- ---GPAAKQQ LLSKRTFFSS SSTWDDKKQY IQDDDDRRVN NN-PLKEEAA PPPVFFLKGR RLLGPQQMQQ LLSRRSLLSS SSPWDDKKQY ICDDDDVVIK KKEKLKEERR PPARYYVKGR REEGPQQMQQ LLSKRSLLSS SSPWDDKKQY ---------- ---------- ---------- ---------- ---------- ---------- VN-------- ---------- ---------- -------MSS QQSKRSLLAA AANWDD---- VN-------- ---------- ---------- -------MSS SSSQRTLLAA AANWDD---- YYPEGLKKKG WWKLAANN-- ------PIID DDEFFFFFVV VVFFE---RS QLGGASSDYY YYP-GLRRRG WWKVVVNN-- ------PLLE EEEFFFFFVV VVFFR---RA QLGGATTDFY YYPDGVPPPA AALAAAGG-- ------PLLA AADYYYYWVV VVFFD---RA QLGGCTTDFY YYPDGVPPPG VVMAVVGG-- ------GLLD DDDYYYYFVV VVFFD---RA QLGGCTTDFY YYPGDRGGGA AAMAVVGG-- ------ELLD DDDFFFFWVV VVFFA---RS QLGGCTTDFY YYPEGIDDDG WWKLAAGG-- ------PFFD DDKFFFFFLL LLWWK---RP QLGGCSSDYY YYPDGIKKKG WWKVVVNN-- ------PFFD DDNFFFFFVV VVFFE---RV QLGGASSDYF YYPVGIRRRG WWKAAADD-- ------PLLD DDGFFFFFTT TTVVD---RP QLGGSSSDYY YY-PDLIIIR EEVMQQVVDV DDDDTTVLLN NNNFFFFLVV VVFFKLLLLA EYGGCSSDW- YY-PNLIIIR EEVMQQIIDV DDDDTTALLN NNNFFFFLVV VVFFKLLLLA EYGGCSSDW- YY-PDLIIIR EEVMQQIIDV DDDDTTVLLN NNNFFFFLVV VVFFKLLLLA EYGGCSSDW- YY-PDLIIIR EEVMQQIIDV DDDDTTVLLN NNNFFFFLVV VVFFKLLLLA EYGGCSSDW- YY-PDLIIIR EEVMQQVVDV DDDDTTVLLN NNNFFFFLVV VVFFKLLLLA EYGGCSSDW- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YY-PDLIIIR EEVMQQVVDV DDDDTTVLLN NNNFFFFLVV VVFFKLLLLA EYGGCSSDW- YY-PDLIIIR EEVMQQIIDV DDDDTTVLLN NNNFFFFLVV VVFFKLLLLA EYGGCSSDW- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YY-PDMIIIK EEVMQQIIDV DDDDTTELLN NNNFFFFLVV VVFFKGGGLA EYGGCSSDW- YY-PDLLLLK EEVMQQIIDV DDDDTTKLLN NNNFFFFLVV VVFFKDDDLA EYGGCSSDW- YY-PGLVVVE KKHIQQIIDV DDDDTTEIIN NNNFFFFFVV VVFFADDDLA EYGGCSSDW- YY-PKLVVVE QQHIQQIIDV DDDDTTEIIN NNNFFFFFVV VVFFADDDLA EYGGCSSDW- YY-PELMMMD KKHIQQIIDV DDDDTTEIIN NNNFFFFFVV VVFFDEEELA EYGGCSSDW- YY-PEIMMME KKHIQQIIDG DDDDTTEIIN NNDFFFFFVV VVFFDDDDLA EYGGCSSDW- YYGQDLVVVK KKHMQQIIDV DDDDTTEIIN NNNFFFFFVV VVFFAEEELA EYGGCSSDW- YY-PEHVVVK SSTMQQVVNI DDDDPPEIIN NNDFFFFLII IIFFKGGGLA EYGGCSSDW- YY-PENVVVR SSTMQQIIDV DDDDPPIIIN NNNFFFFLII IIFFKGGGLA EYGGCSSDW- YY-PNVVVVK EEVMQQIIDV DDDDTTEVVN NNNFFFFLVV VVFFKNNNLA DFCGSSSDL- YY-PEMVVVA AATIQQLLDI DDDDVVELLN NNNFFFFLVV VVFFGYYYLP E--------- YY-PKMVVVS QQHILLIIDV DDDDTTVLLN NNDFFFFLVV VVFFNYYYLP EYGGCSSDWA ---------- ---------- ---------- ---------- ---------- ---------- ---------K KKDDQQYYLK AAAAYYNLLV VVDFFFFAVV VVFFELLLRA IFSSLSSS-- ---------K KKDDQQFFLK LLLLYYYLLK KKQFFFFAII IIFFALLLRP QFARLAAGAD ------- ------- SKKR--- S------ S------ ------- ------- S------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- D------ ------- ------- NLLVQAR 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMMMMNSAAK QPSSEATPPC RTAAAAAVPP GLLTLLADGA MQSSSSLLTT TTASSLLTPP gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPPRRIIKAY QEEEAWTTTS AIQVLSSSSP RSGTRVPGVV EISSAAVVAV PPPAAQWAGA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------GA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------GH ---------- ---------- ---------- ---------- ---------- ------LLFD ---------- ---------- ---------- ---------- ---------- ---------- ---------M AGGGSAPPPL PLNNRPTTTP HPASPHPRPP LTRLVVRRPI NNNRRPCPLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------G- ---------- ---------- ---------- ---------- ---------- --------SG ---------- --------AI IFFFKRRRPP FPPMMAAMMK KKPEEELAAA CCYGGTGINN ---------- ---------M MLLLKPPPPP FPPDDAAMMR RRPEEEIAAA AAYGGTGVNN ---------- ---------- -MMMRPPPPP FAPLLAAMMQ QQAEEEFAAA LLSDDFS--- ---------- ---------- -MMMRPPPPP FAPLLAAMME EEAEEEFAAA LLSDDFS--- ---------- ---------- -LLLRPPPPP FPALLAAMME EEVEEELAAA MMSDDAS--- ---------- ---------M MWWWKPPPPP FPPLLAAAAK KKPEEEIAAA MMDEERK--- ---------- ---------M MWWWRPPPPP FPPMMAAVVK KKAEEELAAA RRNMMANG-- ---------- ---------M MWWWRPPPPP FPPMMAAMMQ QQREEELGGG LLDGGRE--- ---------- ------MAKC C----CCCPP YTLAAMMKK- --REEEIVVV CCYNNTGTEE ---------- ---------- ---------- -------MM- --REEEIVVV CCYNNTGIEE AAAALLIIII APGLP-HSQC C----CCCPP YSLAAMMKK- --REEEIVVV CCYNNTGIEE ---------- ---------- ---------- -----MMKK- --REEEIIII CCYNNTGIEE ---------- ------MAKC C----CCCPP YTLAAMMKK- --REEEIVVV CCYNNTGTEE AFFFLLQQQQ SVPMPATAKC C----CCCPP YTLAAMMKK- --REEEIVVV CCYNNTGTEE ---------- ------MAKC C----CCCPP YTLAAMMKK- ---------- -------TEE ---------- ------MAKC C----CCCPP YTLAAMMKK- --REEEIVVV CCYNNTGTEE HTTTQQPPPP WFGQWETAKC C----CCCPP YTQAAMMKK- --REEEIVVV CCYNNTGTEE DQQQNNTTTT ELYCLFSPKC C----CCCPP YTLAAMMKK- --REEEIVVV CCYNNTGTEE ---------- ------MAKC C----CCCPP YTLAAMMKK- --REEEIVVV CCYNNTGTEE QHHHMMEEEE GAVEAANGTC CTTTAKKKPP YTLAAMMEEK KKREEELVVV CCYGGTGINN ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MKC C----CCCPP YSLAAMMKK- --REEEIVVV CCYSSTGINN ----MMAAAA TVHGVEKSVN NCCCKSSSPP YSISSMMSS- --REEELIII AAYGGTGIEE ----MMGGGG TVHAVEVNQQ QCCCKSSSPP YSLAAMMSS- --REEELIII AAYGGTGIEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R RQQQVGGGPP YTLAAMMSS- --SEEELIII AAYGGTGIDD ---------- ----AANGAC CGGGATTTPP YTLAAMMEEK KKREEELLLL CCYGGTGINN ---------- ----MPCGKC C-------PP YSAAAIIKK- --REEEVLLL AA---NAADD ---------- ----M-CPKC C-------PP YSAAAIIKK- --REEEVLLL AA---HARDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------SE ECCCKCCCPP YTLAAVVRRN NNVEEELLLL CCQNNLDEEE ---------- ---------- ---------- -----MMRRS SSREEELLLL TTQNNLDEPP ---------- ---------- --------PP LT-IILLIIS SSDRRRLYYY WWHDDIRQYY ---------- --ALA-LAGL LRRRAFFFDD TQPMMPPKKI IIQEEEFVVV TTGEEGMGDD GPPPMMHHHH FAALSLLAAA AGGGVRRRDD TAPMMKKKKI IIQEEEYVVV TTGEEGVGDD NRADDDDIAV VVVDVVVVVP PPKKSETSKK IIIVVHHHKE EEELHHFFFF FGAACCSSAC NAPDDDDLAV VVVDVVVVVP PPKKSPTGKK VVVIIYYYKD DEELHHFFFF FGAACCSSAC -RPDDDDLAV VIIDVVVVVP PPGGSSTGKK IIIVVHHHTT TEEFHHFFFF FGAACCSSSS -KPDDDDLAV VIIDVVVVVP PPGGSPTGQQ IIIVVHHHTT TEEFHHFFFF FGAACCSSAS -KPDDDDLAV VVVDVVVVVP PPTTSEKGQQ IIIVVHHHQI IEEFHHFFFF FGAACCSSAS -QPDDDDIAV VVVDVVVVVP PPAASPRASS IIIVVGGGQA AEELHHFFFF FGAACCSSCC -KPDDDDMCV VVVDVVVVVS SSQQSSTGQQ VVVVVGGGVD DEELHHFFFF FGAACCSSMC -RPDDDDLGV VLLDLLLLLP PPDDSGTAQQ IIIVVGGGRE EEELHHFFFF FGAACCSAAC EAPDDDDLAT TVVDVVVVVP PPKKSPQSQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- EAPDDDDLAT TVVDVVVVVP PPKKSPHSQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- EAPDDDDLAT TVVDIIIIIP PPKKSPQCQQ VVVIIHHHRP PEELHHSSSS SGAACCSSC- EAPDDDDLAT TVVDVVVVVP PPKKSPQCQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- EAPDDDDLAT TVVDVVVVVP PPKKSPQCQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- EAPDDDDLAT TVVDVVVVVP PPKKSPQCQQ VVVIIEEE-- ---------- ---------- EAPDDDDLAT TVVDVVVVVP PPKKSPQCQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- EAPDDDDLAT TVVDVVVVVP PPKKSPQCQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- EAPDDDDLAT TVVDVVVVVP PPKKSPQSQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- EAPDDDDLAT TVVDVVVVVP PPKKSPQCQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- EAPDDDDLAT TVVDVVVVVP PPKKSPQCQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- NKLDDDDLAT TVVDLLLLLP PPSSSPTSQQ VVVIIHHHRP PKKLHHSSSS SGSSCCSSC- ---------- ---------- ---------- ---------- -EELHHSSSS SGTTCCSSC- NKPDDDDLAT TVVDVVVVVP PPKKSPSSQQ VVVIIHHHRP PEELHHSSSS SGTTCCSSC- EKPDDDDLAT TVVDVVVVVP PPSSSPTSKK VVVIIHHHRP PEELHHTTTT TGSSCCSSC- EKPDDDDLAT TVVDLLLLLP PPNNSPTSKK VVVIIHHHRP PEELHHTTTT TGSSCCSSC- ---------- ---------- ---------- ---------- -EELHHSSSS SGSSCCSSC- DKPDDDDLAT TVVDVVVVVP PPSSSPSSSS VVVIIHHHRP PEELHHSSSS SGSSCCSSC- NKPDDDDLGT TVVDVVVVVP PPNNSPTSQQ VVVIIHHHRP PEELHHSSSS SGAACCSSC- DGPDDDDIFT TVVDVVVVVP PPEESDTCQQ VVVIISSSRD DEEVHHTTTT TGAACCSSC- DGPDDDDIFT TVVNVVVVVP PPEESETCQQ IIIIISSSRD DEEVHHTTTT TGAACCSSC- ---------- ---------- ---------- ---------- ---------- ---------- EHGDDDDLAT TVVDVVVVVP PPAASPTCQQ VVVIIHHHRY YEELHHSSSS SGTTCCSSCF PHGDDDDLST TVVDVVVVVP PPEESPTCQQ IIIVVHHHRF FEELHHSSSS SGAACCSSCY YDITTTTRKN NPPRMMMMMG GGQQVFLGSS VVVLLKKKDP PKKELDSSSS SQPPRRILK- DEQDDDDLVT TIIDLLLLLP PPGGSATGQQ VVVIINNNSS SEEAHHGGGG GGAA------ DEQDDDDLVT TVVDAAAAAP PPKKSPQGKK VVVVVNNNTS SEEAHHSSSS SDDD------ NGGKPPPNNI ERRRRFFFLL PGRIIDDDTK PPPPPEPKII IKKKVEEEPE EKKGGYYYSR NAAKPPPFFL ERRRRYYYLL PARVVDDDTK PPKKKRPAVV AKKKIEEEPE EGGGGYYYTK LTTHAAAFFL ERRRRFFFLL PGRIIDDDTK PPPPPQARII HKKKIEEEPD DAAGGYYYSR LAAHAAAFFI ERRRRYYYLL PGRIIDDDTK PPPPPKAKII HKKKIEEEPE EKKGGYYYSR LTTHAAAFFL ERRRRYYYLL PGRVVDDDVK --PPPKAKII HKKKIEEEPE EAAGGYYYSR NAAHPPPHHM ERRRRYYYLL PGRLLDDDTK PPPPPKPFLL AKKKVEEEPE EEEGGYYYSR NAAHPPPHHV ERRRRYYYLL PDHLLDDDTK PPPPPQPKVV VKKKVDDDPN NEEGGYYYAR YAAHPPPHHV ERRRRYYYLL PGRVVDDDTK PPPPPEPRII VKKKVEEEPE ERRGGYYYSR -FFDSSSTTK SRRRNKKKLL PGRVVDDDVG SSPPPAPKLL HKKKVEEEAS SAANNVVVSN -FFDSSSTTK SRRRDKKKLL PSRVVDDDVG SSPPPAPKLL HKKKVEEEPN NAANNLLLGN -FFDSSSTTK SRRRTKKKLL PCRVVDDDVG SSPPPAPKLL HKKKVEEEAE EAAGGLLLGY -YYDIIITTK ARRRTKKKLL PARVVDDDVG TTPPPAPKLL HKKKVEEEPK KTTNNLLLGF -FFDSSSTTK SRRRTKKKLL PSRVVDDDVG SSPPPAPKLL HKKKVEEEPE EAAEELLLAF ---------- ---------- ---------- ---------- --------PK KAAEELLLAF -FFDSSSTTK SRRRTKKKLL PSRVVDDDVG SSPPPAPKLL HKKKVEEEPK KAAEELLLAF -FFDSSSTTK SRRRTKKKLL PSRVVDDDVG SSPPPAPKLL HKKKVEEEPK KAAEELLLAF -FFDSSSTTK SRRRNKKKLL PSRVVDDDVG TTPPPAPKLL HKKKVEEEAK KEEGGLLLGT -FFDSSSTTK SRRRTKKKLL PS-------- ---------- ---------- ---------- -FFDSSSTTK SRRRTKKKLL PSRVVDDDVG SSPPPAPKLL HKKKVEEEPK KAAEELLLAF -HHDPPPSSA KRRRRFFFLL PSRVVDDDTA TTPPPTPSLL HKKKVEEESE EEEGGLLLGF -YYDAAASSK VRRRNKKKLL PCRVVDDDVG TTPPPAPRII HKKKTEEEPY YWWGGLLLAN -YYDSSSSSK VRRRNKKKLL PCRVVDDDVG SSPPPAPRII HKKKTEEEPY YWWGGLLLAN -HHDPPPSSA ERRRRFFFLL PSRIIDDDTK TTPPPSPSLL HKKKVDDDPA AQQGGLLLAY -HHDPPPSSA QRRRRFFFLL PGRIIDDDTK TTPPPAPSLL HKKKVEEEPE ETTGGLLLAY -HHDAAASSA DRRRRYYYLL PSRIIDDDTK EEPPPAPSLL YKKKYDDDPK KEEGGLLLAY -HHDAAASSV DRRRRYYYLL PSRIIDDDTK EEPPPAPSLL YKKKYDDDPK KDDGGLLLAF -HHDPPPSSA SRRRRFFFLL PSRVVDDDTL KKPPPAPALL HKKKVEEEAE EEEGGLLLGF -HHKPPPTTE KRRRSHHHLL PCRIINNNVE NN---KIYLL EHHHTEEEPS SSS--LLLSF -HHKPPPTTE KRRRSHHHLL PCRIINNNVE NN---EIYLL QHHHTEEEPS SAA--LLLSF ---------- --------MM RKVVVFFFVG GG-------- ---------- ---------- -GGKEEEVVP TRRRDRRRLL PCRIIDDDTG TTPPPAPKLL AKKKVEEEG- -KKDDCCCTA ESSKTTTVVP KRRRDRRRLL PSFLLDDDVV TTPPPKPEII VKKKTDDDG- -KKNNVVVTA ---KRRRVVQ GGGGPQQQMM LSRTTTTTSL YYAAADKQFF YPPP------ -KKVVLLLAI ---------- DRRRRFFFFF GGRFFDDDVH SSPPPNPKLL HKKKTDDDT- -DDGGVVVVG ---------- DRRRRYYYLL GGKFFDDDVH SSPPPRPVLL SKKKTTTTD- -KKGGVVVVG RLTVCCPPPI IIIIIGGGNE --EEGEEGGG GGIIIMMSFE EEKWWDRGGD Q--------- KYTVCCPPPI IIIIIGGGGP --DDGEEGGG GGIIILLTFE EERWWYRGGP Q--------- RPTVCCPPPI IIIIVGGGGA GGDDGDDPGG GGIIIIITFD DDRWWDRGGP Q--------- RPTICCPPPI IIIIVGGGGG GGDDGNNPGG GGVVVIITFE EERWWDRGGP Q--------- RPTICCPPPI IIIIVGGGGG GGDDGDDPGG GGIIIIITFE EERYYDRGGE Q--------- RPTVCCPPPI IIIIVGGGNA --EEGKKGGG GGIIIMMSFE EERWWERGGP Q--------- RPTVCCPPPI IIIIIGGGSP --EEGEEGGG GGIIIIINLE EERWWDRGGD Q--------- RPTICCPPPV VVVVVGGGSP --EEGDDGGG GGVVVVVSFD DDRWWERGGP Q--------- NTTSCCAAAE EEEEMLLLGD --LLQNNGSS SSFFFLLTFE EETWWPGGGA S--------- NLTSCCAAAE EEEEMLLLGD --PPQNNGGG GGFFFLLTFE EETWWPGGGE A--------- YVTSCCAAAE EEEEMLLLGD --SSKNNGGG GGFFFLLTFE EETWWPGGGA A--------- FFTSCCPPPE EEEEMLLLGD --PPENNGGG GGFFFLLTFE EETWWPGGGA A--------- FLTSCCAAAE EEEEMLLLGD --VVKNNGGG GGFFFLLTFE EETWWPGGGA A--------- FLTSCCAAAE EEEEMLLLGD --VVKNNGGG GGFFFLLTFE EETWWPGGGA A--------- FLTSCCAAAE EEEEMLLLGD --VVKNNGGG GGFFFLLTFE EETWWPGGGA A--------- FLTSCCAAAE EEEEMLLLGD --VVKNNGGG GGFFFLLTFE EETWWPGGGA A--------- TPTSCCPPPE EEEEMLLLGD --PPKNNGGG GGFFFLLTFE EETWWPGGGS A--------- ---------- ---------- ---------- ---------- ---------- ---------- FLTSCCAAAE EEEEMLLLGD --VVKNNDGG GGSSSVVRLE EE-------- ---------- FPTSCCAAAD DDDDMLLLGD --KKENNGNN NNGGGLLEFN NNRGGRLFFP I--------- NLTSCCGGGE EEEEMIIIGD --PPYNNGGG GGFFFLLTFE EENWWEGEEA A--------- NPTSCCGGGE EEEEMLLLGD --PPCNNGGG GGFFFLLTFE EENWWEGEES A--------- YPTSCCAAAE EEEEMLLLGD --KKDNNGNN NNGGGLLDFN NNRWWPGHHS P--------- YPTSCCAAAE EEEEMIIIGD --KKDNNGNN NNGGGLLEFN NNRWWPGHHS P--------- YPTACCAAAE EEEELLLLGD --EEENNGNN NNGGGLLDFN NNRWWPGHHS P--------- FPTACCTTTE EEEELLLLGD --EEENNGNN NNGGGLLDFN NNRWWPDIIS P--------- FPTSCCAAAE EEEEMLLLGD --KKENNGNN NNGGGLLEFN NNRWWPGHHS P--------- FPTSCCAAAN NNNNMLLLGE --AANTTGNN NNFFFLLTFE EETWWDEKKT V--------- FPTSCCAAAN NNNNMLLLGE --AADSSGNN NNFFFLLTFE EETWWDGKKV V--------- ---------- ---------- ---------- ---------- ---------- ---------- APTTCCPPPN NNNNMMMMGD --AAENNG-- --DDDVVNFE EETWWGDRRK A--------- APTTCCAAAN NNNNMMMMGD --AAEYYG-- --DDDIIDFN NNTWWGDKKK A--------- ISTAYYPPPA AAAAKVVVNE --SSLVVLNN NNGGGQQENG GGKGGSQFFE E--------- GPTFAAPPPM MMMMISSSND --DDDGGTAA AALLLEEGEY YYYWWTADDD MAAVVVDDAV GPTLAAPPPM MMMMISSSNN --KKDGGTAA AALLLEEGEY YYHWWTDGGD LAAIIT--KY -----YDDDD DWWNPPEVVS SEN---TIIE DG-LKLELLK KDRRNNNNII FWDDRRRKKK -----YDDDD DWWNPPGVIT TER---CFFE EG-FSLELLK KEAANNNNLL VWDDAAAKRR -----YDDDD DWWNPPDYVS SEP---QFFE NG-IVPELLL LAKKHHHHLL FWDDRRRARR -----YDDDD DWWNPPDYVT TEP---QFFE NG-IVPELLL LSKKHHHHLL FWDDRRRARR -----YDDDD DWWNPPDYVS SEP---QFFE NG-IVPELLL LSKKHHHHII FWKKRRRDKK -----YDDDD DWWHGGDTVT TED---MVVE DG-LVPDLLL LGRRRRRRLL FWDDTTTRRR -----YDDDD DWWHGGDTLT TER---MVVE SG-VLGDLLL LAKKHHHHLL VWDDYYYRRR -----YDDDD DWWHGGDTVT TEN---MIIE GG-LDPQLLL LNGGRRRRLL IWDDRRRRRR -----YDDDD DWWQRRNVVS SEN---VFFK DGFNPAHEEA A-LLSSSSII VWDDQQQREE -----YDDDD DWWQRRNIVS SEN---VFFK DGFNPAHEEA A-LLSSSSII VWDDQQQREE -----YDDDD DWWQRRNVIS SEN---VFFR DGFNPADEEA A-LLSSSSLL VWDDQQQREE -----YDDDD DWWQRRNVIS SEN---VLLR DGFNPADKKA A-LLSSSSLL VWDDQQQREE -----YDDDD DWWQRRNVIS SEN---VLLR DGFNPADEEA A-LLSSSSLL VWDDQQQHEE -----YDDDD DWWQRRNVIS SEN---VLLR DGFNPADEEA A-LLSSSSLL VWDDQQQREE -----YDDDD DWWQRRNVIS SEN---VLLR DGFNPADEEA A-LLSSSSLL VWDDQQQREE -----YDDDD DWWQRRNVIS SEN---VLLR DGFNPADEEA A-LLSSSSLL VWDDQQQREE -----YDDDD DWWQRRNVIS SEN---VVVQ NGFNPADEEA A-LLKKKKLL VWDDQQQREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -IN---LRRL TGSRDYPSSA A-RRGGGGTT ---------- -----RTTTT TLLEAAGLWS SIL---FYYT TGAELMCTTA A-GGVVVVSS LDNNIIIMVV -----YDDDD DWWQRRNVIS SEK---AFFA LGFKMEEQQA A-MMHHHHLL VWDDTTTERR -----YDDDD DWWQRRNVIS SEK---AFFA LGFKMEDQQA A-HHHHHHLL VWDDTTTERR -----YDDDD DWWQRRNTIS SST---AFFT KGFDLQHAAD D-LLRRRRLL CIQQAAAREE -----YDDDD DWWQRRNTIS SSK---AFFL QGFNLQHAAD D-LLRRRRLL VYSSPPPGEE -----YDDDD DWWQRRKTIS SSK---AFFS KGFDLQHAAD D-LLSSSSLL VYSSPPPGEE -----YHHHH HWWQRRKTIS SSK---AFFS KGFNLQHAAD D-LLSSSSLL VYSSPPPGEE -----YDDDD DWWQRRKTIS SSA---AFFR TGFDLQHQQD D-LLRRRRLL VYDDPPPGEE -----YDDDD DWWQRRNVIS SEN---HIIK KGFNPAHGGE E-LLNNNNVV IFEEDDDSKK -----YDDDD DWWQRRNIIS SEN---HIIK KGFNPAHPPE E-LLNNNNVV IFEEDDDTKK ---------- ---------S SLV---TVVC RDEELKCPPE E-LLKKKKKK VY-------- -----YDDDD DWWQHHNVVA AEK---LFFR RGYHPTDDDD DRQQCCCCLL FYRRQQQEEE -----YDDDD DWWQYYDVVS SEN---KWWR RGWKNVDEED DMQQCCCCLL FYKKSSSTTT -----LSSSS SHHN--EKES SRI---MAAF ESSESFLKKT TGLLQQQQVV EVLL------ VVDDGYDDDD DRRLRRNVLT TSSNNNMMMD FGQMLQDEEA AMRRNNNNII QWDDHHHTQQ YYDDGYDDDD DRRLRRNLVT TSNNNNMMMD FGKMLADEEA AMHHNNNNVV TWDDHHHTQQ KRHHSSSSGE ENAL-----R LPTTTGGFNM VSLKKKDSSL LWWWFYYGWW AAAEVVPPPE RHYYAAAAGE EHVL-----R LPTTTGGFNV VNTKKKDSSL LWWWFYYGWW AAAEVVEPPE RNQQTTTTGQ QHAL-----R APVVVGGFGV VDTTTTNEGT TWWWWRRGFF VVVKTTPPPT RNQQTTTTGN NHAL-----R APVVVGGFGV VDTTTTNEAT TWWWWRRGFF AAAETTPPPP KNQQTTTTGN NHAL-----R APSSSGGFGV VDTTTTNQGT TWWWWQQGFF AAAKTTDPPD RHQQEEEEGE EHVF-----R APTTTGGFNC VSLKKKDSST TWWWYRRDWW VVVRVVPAAD RHQQTTTTGE EYAL-----R APTTTGGFNC VSLKKKDSAL LWWWYRRGWW LLLKVVPPPS RHQQAAAAGE EHVL-----R APAAAGGFGV VSLEEEDSAL LWWWHRRGWW IIIRVVPPPE EIQQTTTTT- -DIP---LLR LPSSSGGFGC ASSNNNIRFE EEEEG----- ------VVVQ EIQQTTTTK- -DIP---LLR LPDDDGGFGC ASSNNNIRFE EGGGG----- ------VVVQ EIQQTTTTQ- -DIP---LLR LPDDDGGFGC ASSTTTIRFQ QGGGG----- ------VVVQ EIQQTTTTQ- -DIP---LLR LPDDDGGFGC ASSTTTIRFE EDDDG----- ------AVVQ EIQQTTTTK- -DIP---LLR LPDDDGGFGC ASSTTTIRFE EGGGG----- ------VVVQ EIQQTTTTK- -DIP---LLR LPDDDGGFGC ASSTTTIRFE EGGGG----- ------VVVQ EIQQTTTTK- -DIP---LLR LPDDDGGFGC ASSTTTIRFE EGGGG----- ------VVVQ EIQQTTTTK- -DIP---LLR LPDDDGGFGC ASSTTTIRFE EGGGG----- ------VVVQ EIQQTTTTP- -DIP---LLR LPAAAGGFGC ASSTTTIRFE EGGGG----- ------VVVE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VIEESSSSQ- -DGANPILLR IKNNNDDYVV ESFSSSGGGD DAAAY----- ------LKKD RRQQTTTTG- -DIP---LLR LPDDDGGLGC ASSTTTVRFK KDDDG----- ------AVVK RLQQTTTTG- -DIP---LLR LPDDDGGLGC ASSSSSIRFK KDDDG----- ------AVVQ ELQQTTTTG- -TLP---LLR LPAAAGGFGS ASSNNNMRFQ QDDDG----- ------HAAP EIQQTTTTG- -KLP---LLR LPAAAGGFGS ATSNNNMRFQ QDDDG----- ------HVVS EMQQLLLLG- -TLP---LLR LPSSSGGYGS ASSNNNMRFS SDDDD----- ------YVVS EIQQLLLLG- -TLP---LLR LPSSSGGFGS ASSNNNMRFS SDDDE----- ------HVVS ELQQTTTTG- -TLP---LLR LPSSSGGYGC ATSNNNMRFA ADDDG----- ------HAAS KYQQTTTTPP PLLP---LLR LPTTTAAFGC AGSGGGIRIE EEEENSS--- ------AVVF KHQQTTTTPP PRLP---LLR LPTTTAAFGC AGSAAAIRIE EKKKNPP--- ------AVVT ---------- ---------- ---------- ---------- ---------- ---------- ELQQTTTTG- -DTP---LLR LPRRRGGYGC AXXXXXXXX- ---------- ---------- TLQQTTTTG- -DTP---LLR LPKKKGGFGC ANAKKKVHFS SDDDSDD--- ----FFKDDP ---------- ---------- ---------- ---------- ---------- ---------- QPKKVVVVPA AP-----LLR PSNNNAAFTT ATSQQQLLID DAAAG----- ---------E QPKKVVVVPA AP-----LLR AEAAACCFST ATSQQQLLIG GEEEG----- ---------E NLLLEEEIKK KAAPPLTTID ISSSSLDDDK KFLLSSSSGG EVRYDNPFPV LLLTGKVLLL PLLLPPPVKK KMMPPLTTID ISSSSLDDDR RFVVSSSSGG ELRYDNPHPR LLLAGRVIII ELLLPPPLQG GAAPPLTTID LSSSSLDDDR RFVVSSSSGG EMRYDDPHPV LLLAGSVIII KLLLPPPLQG GAAPPLTTID LSSSSMDDDR RFVVSSSSGG EMRYDDPRPK LLLAGSVIII DLLLDDDLKG GAAPPLTTID LSSSSLDDDK KYVVAAAAGG EMHYDDPMPV LLLTGKVIII QLLLPPPVKK KAAPPLTTID LSSSSMDDDR RFVVSSSSGG DLLYDDPFPK LLLTGKVIII QLLLPPPIKK KAAPPLTTIN LSSSSVDDDR RFVVSSSSGG ELHYDDPFPR LLLTGKVIII QLLLPPPLKG GAAPPLTTIN LSSSSLDDDR RFVVSSSSGG ELRYDDPFPR HHHTGSVLLL SKKKVVVKWP PEEPGLTTIL LSSSSLDDDR RFFFSSSSLG DIRYDNPQPR LLLTGQILLL SKKKVVVKWP PEEPGLTTIL LSSSSLDDDR RFFFSSSSLG DIRYDNPKPR LLLTGQILLL PKKKVVVKWP PEEPGLTTIL LSSSSLDDDR RFFFSSSSLG DLRYDDPQPR LLLTGQLLLL PKKKVVVKWP PEEPGLTTIL LSSSSLDDDH HFFFSSSSLG DIRYDDPQPR LLLTGQLLLL PKKKVVVKWP PEEPGLTTIL LSSSSLDDDR RFFFSSSSLG DLRYDDPQPR LLLTGQLLLL PKKKVVVKWP PEEPGLTTIL LSSSSLDDDR RFFFSSSSLG DLRYDDPQPR LLL------- PKKKVVVKWP PEEPGLTT-- ---------- ---------- ---------- ---------- PKKKVVVKWP PEEPGLTTIL LSSSSLDDDR RFFFSSSSLG DLRYDDPQPR LLLTGQLLLL PKKKVVVKWP PEEPGLTTIL LSSSSLDDDR RFFFNNNNLG DMRYDDPKPR LLLVGQILLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YAAAVVVAFV VSSSNEPPAW IFFFFFSDDL LLFFLLLL-- ---------- ---------- SKKKVVVEWP PEEPGLTTIL ISSSSLDDDR RFFFSSSSLG DIRYDDPRPK LLLVGQILLL SKKKVVVEWP PEEPGLTTIL ISSSSLDDDR RFFFSSSSLG DIRYDDTRPK LLLVGQILLL PLLLVVVQWP PEEPGLTTFL ISSSSLDDDR RFFFVVVVLG DIRYNDLKPV LLLTGQLVVV PLLLVVVQWP PEEPGLTTFL ISSSSLDDDR RFFFVVVVLG DIRYNDVKPK LLLTGQVAAA PLLLVVVEWP PEEPGLTTFL ISSSSLDDDR RFFFVVVVLG DIRYNDPKPV LLLTGQIVVV PLLLVVVEWP PEEPGLTTFL ISSSSLDDDR RFFFVVVVLG DIRYNDPKPV LLLTGQIVVV PLLLVVVRWP PEEPGLTTFV ISSSSLDDDR RYLLVVVVLG DIRYNDPAPV LLLAGQVAAA SKKKVVVSWP PEEPALTTIL ISSSSMDDDR RFVVSSSSLG DIRYDDPLVK LLLNSQVIII SKKKVVVEWP PDDPALTTIL ISSSSMDDDR RFVVSSSSLG DIRYDDPKPK LLLNSQVIII ---------- ---------- ---------- ---------- ---------- ---------- ----GGGEGE EMMGGMTTIL ISSSSLDDDR RYFFSSSSRG DVRYDDRAPR LLLTGQVLLL LVVVTTTGGE EDDGGMSSII ISSSSLDDDR RFVVNNNNRG DVRYDDPEPK LLLTGQLLLL ---------- ---------- ---------- ---------- ---------- ---------- AKKKVVVAIP PAAIPLVVIS IAAAAADDDQ QTIINNNNMG KTRFDDPHPF QQQIYEKIII AKKKVVVAIP PAAVPLVVIS ISSSSNDDDS SRVVNNNNMG KTRFDDPHPR QQQVYEKIII GGIFRRAHHP ---------- --------AA GKTTTGGGPQ MDGRRVVYVV VTNNNSLYSW GGLYRREHHP ---------- --------SS GETTTGGGPQ MDGRRVVYII ITNNNSLYSW GGIARRAHHP ---------- --------NN GTAAAGGGPQ MDGRRVVYWW WTNNNSLYSW GGIARRTHHP ---------- --------NN GAAAAAAAPQ MDGRRVVYWW WTNNNSLYSW GGIVKKTHHP ---------- --------NN GTGGGYYYPQ MDGKKVVYWW WTNNNSLYSW GGIVRRAHHP ---------- --------KK NANNNGGGPQ MDGRRVVYFF FTNNNSLYGV GGIVRRAHHP ---------- --------TT SENNNGGGPQ MDGRRVVYFF FTNNNSLYRW GGIVKKAHHP ---------- --------AA SPNNNGGGPQ MDGRRVVYFF FSNNNSLYAW GGSIRRGSSV VVLLEE---C CQQPPPELKK GRPPPGGGPQ MDGKKLLYAA ATTTTSLYSW GGSIKKGSSV VVLLEE---C CQQPPPELKK GRPPPGGGPQ MDGKKLLYVV VTTTTSLYSW GGSIKKGPPV VVLLEE---S SQQPPPELKK GKPPPGGGPQ MDGKKLLYVV VTTTTSLYSW GGSIKKDPPV VVLLDD---S SQQPPPELKK GQAAAGGGPQ MDGKKLLYVV VTTTTSLYSW GGSIKKGPPV VVLLEE---S SQQPPPELKK GRAAAGGGPQ MDGKKLLYII ITTTTSLYSW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGSIKKGPPV VVLLEE---S SQQPPPELKK GRAAAGGGPQ MDGKKLLYII ITTTTSLYSW GGSIKKGPPV VVLLEE---S SQQPPPELKK GRPPPGGGPQ MDGKKIIYVV VTTTTSLYSW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGSIRRGPPV VVLLEE---C CQQPPPDVKK GKPPPGGGPQ MDGKKLLYVV VTNNNSLYSW GGSIRRGPPV VVLLEE---C CQQPPPDVKK GIPPPGGGPQ MDGKKIIYVV VTSSSSLYSW GGLIKKGPPV AAIIGG---W WQQSSSDPQQ GKRRRGGGPQ MDGKKLLYVV VTNNNSLFSW GGLIKKGPPV AAVVKK---W WQQSSSDPQQ GKRRRGGGPQ MDGKKLLYVV VTNNNSLFSW GGLLKKGPPV AAVVGG---F FQQFFFDPKK GSRRRGGGPQ MDGKKLLYAA ATNNNSLFSW GGLLKKGPPV AAVVGG---F FQQFFFEPKK GSRRRGGGPQ MDGKKLLYAA ATNNNSLFSW GGLLKKGEEV YYVVTT---E EQQYYYSPKK GRRRRGGGPQ MDGKKIIYVV VTNNNSLFSW GGSVTTENNV VVLLEE---- -PPIIIELKK GKEEEGGGPQ MDGKKLLYVV VTTTTSLYKW GGSISSETTV VVLLEE---- -EEIIIPLKK GQEEEGGGPQ MDGKKLLYVV VSTTTSLYKW ---------- ---------- ---------- -----GGGPA KDGKKLLYVV VTNNNSFYSW GGAIRRDPPR VVLLNN---E EAAPPPEVKK GRLLLGGGPQ MDGRRLLYVV VSSSSSLFSW GGAISSDPPN IIVVKKEEEE ERRPPPPRKK GREEEGGGPQ MDGKKLLYVV VSSSSSLYSW ---------- ---------- ---------- ---------- ---------- ---------- DRQV------ ---------- ---------- ---------- MDGKKVVYFF FSSSSSLLAW GAQV------ ---------- ---------- ---------- MDGQQLLYYY YTSSSSLLAW WNQQFPEKGW WVVKA----- ----PPPSGG LIDFVDDE-- ----AARSHH QQQVVRLSGS WNQQFP-RGW WAAKV----- ----PPPEGG LLEFVDDR-- ----AARAHH QQQVVRLWGS WDQQFPDPAA AVVLA----- ----PPPDGG LLAWVEEDG- ----YYRAHH QQQIIRLEGS WDQQFPDPGV VVVMV----- ----GGGNGG LLDFVSSDG- ----YYRAHH QQQIIRLEGS WEQQFPGGAA AVVMV----- ----EEENGG LLDWVDDAG- ----YYRSHH QQQIIRLEGS VPQQFPEDGW WVVKA----- ----PPPNGG IFDFLEEKG- ----HHRPHH QQQVVRLQGS WEQQFPDKGW WVVKV----- ----PPPDGG MFDFVDDE-- ----QQRVHH QQQIIRLQGS WEQQFPVRGW WAAKA----- ----PPPGGG LLDFTEEDG- ----LLRPHH QQQIIRLEGS WKQQF-PIRE ESSVQDVDTT TTTTVVVNGG LLNLVDDKEP PLPPAALAHH EEELLRYPGS WKQQF-PIRE ESSVQDVDTT TTTTAAANGG LLNLVDDKEP PLPPAALAHH EEELLRYPGS WKQQF-PIRE ESSVQDVDTT TTTTVVVKGG LLNLVDDKEP PLPPAALAHH EEELLRYPGS WKQQF-PIRE ESSVQDVDTT TTTTVVVKGG LLNLVDDKEP PLPPAALAHH EEELLRYPGS WKQQF-PIRE ESSVQDVDTT TTTTVVVKGG LLNLVDDKEP PLPPAALAHH EEELLRYPGS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WKQQF-PIRE ESSVQDVDTT TTTTVVVKGG LLNLVDDKEP PLPPAALAHH EEELLRYPGS WKQQF-PIRE ESSVQDVDTT TTTTVVVKGG LLNLVDDKEP PLPPAALAHH EEEIIRYPGT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WKQQF-PIKE ESSVQDVDTT TTTTEEEKGG LLNLVDDKEP PGPPVVLAHH EEELLRYPGS WKQQF-PLKE EAAVQDVDTT TTTTKKKKGG LLNLVDDKEP PDPPVVLAHH EEEIIRYPGT WKQQF-PVEK KSSHQDVDTT TTTTEEEKGG LINFVDDAEP PDPPAALAHH EEEMMRYPGT WKQQF-PVEQ QSSHQDVDTT TTTTEEENGG LINFVDDAEP PDPPSSLAHH EEEMMRYPGT WRQQF-PMDK KSSHQDVDTT TTTTEEEKGG LINFVDDDEP PEPPAALAHH EEEMMRYPGT WVSSF-PMEK KSSHQDGDTT TTTTEEEKGG LINFVDDDEP PDPPSSLAHH EEEMMRYPGT WEQQFGQVKK KSSHQDVDTT TTTTEEEKGG LINFVDDAEP PEPPSSLAHH EEEMMRYPGT WDQQF-PVKS SAATQNIDPP PPPPEEESGK MINLIDDKIE EGPPYYLAHH EEEMMRYPGT WDQQF-PVRS SAATQDVDPP PPPPIIITGH MINLIDDKVP PGPPYYLAHH EEEMMRYPGT WKQQF-PVKE ESSVQDVDTT TTTTEEEKGG LVNLVDDKEP PNPPCCLAHH DDDIIRFPGT WKQQF-PVAA AGGTQDIDVV VVVVEEENGG MLNLVDDGEP PYPPGGLPHH EEEMMR---- WKQQF-PVSQ QGGHLDVDTT TTTTVVVNGG ILNLVDDNEP PYPPSSLPHH EEEMMRYPGT ---------- ---------- ---------- ---------- ---------- ---------- W-------KK KKKDQLKAYY YYYYNNNWDG KLVAVDDELG GL----RAHH IIIMMRFGSY W-------KK KKKDQLKLYY YYYYYYYWDG KLKAIDDAEK KL----RPHH QQQMMRFGRY SSDPP-- STDPP-- STDPPK- STDPP-- STDPP-- SSDPP-- SSDPP-- SSDPP-- SSD---- SSD---- SSD---- SSD---- SSD---- ------- ------- SSD---- TSD---- ------- ------- ------- SSD---- TSD---- TSD---- TSD---- TSD---- TSD---- TSD---- TSD---- TSD---- TSD---- ------- TSDNN-- ------- YSS---- YAGGGLQ 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NSSAKKKKKK KQPPEPCRTT AAAAPGGGTA AARRAGAAMS LTTTTAQSLL TPPPGPVVKA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YAAAAWWWFS IIQVVSSPPS SSKTPGVIIS SSSSAAAAAV AAKKQQVVSQ AAAAVQQAPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------EE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------KK ---------- ---------- ---------- ---------- ---------- -------LGG ---------- ---------- ---------- ---------- ---------- ---------- MRRSSAAATL LLNNNPTPPP PPLSPRPTTR RRLLVVVVVR PPYYRRTTVP PPPRLPPPHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------RR ---------- ---------- ---------- ---------- ---------- --------RR ---------- ---------- --AAIPKRRP TTYPSSPPKM MMKKKAEDLV CCYYYYTTIN ---------- ---------- ----MKKPPP TTYPTTPPRD MMRRRAEDIV AAYYYYTTVN ---------- ---------- -----SRPPP TTHASSPPEL MMQQQAEEFT LLSSSSFF-- ---------- ---------- -----TRPPP TTHASSPPKL MMEEEAENFT LLSSSSFF-- ---------- ---------- -----TRPPP TTYPSSAAKL MMEEEGEKLT MMSSSSAA-- ---------- ---------- ----MTKPPP SSYPSSPPRL AAKKKAETIV MMDDDDRR-- ---------- ---------- ----MTRPPP TTYPSSPPRM VVKKKAEKLV RRNNNNAAG- ---------- ---------- ----MSRPPP TTYPSSPPKM MMQQQAERLV LLDDDDRR-- ---------- ---------- MAKKCK-CCP GGPTPPLLEA KK---GEEIL CCYYYYTTTE ---------- ---------- ---------- ---------- MM---GEEIL CCYYYYTTIE HHHAVLIAPA AARGLLPP-- HSQQCK-CCP GGPSPPLLEA KK---GEEIL CCYYYYTTIE ---------- ---------- ---------- ---------- KK---GEEIL CCYYYYTTIE ---------- ---------- MAKKCN-CCP GGSTPPLLEA KK---GEEIL CCYYYYTTTE EEEATLQSVA AAQPMMPPAA TAKKCN-CCP GGSTPPLLEA KK---GEEIL CCYYYYTTTE ---------- ---------- MAKKCN-CCP GGSTPPLLEA KK---G---- --------TE ---------- ---------- MAKKCN-CCP GGSTPPLLEA KK---GEEIL CCYYYYTTTE PPPHAQPWFL LLSGQQWWEE TAKKCD-CCP GGPTPPQQEA KK---GEEIL CCYYYYTTTE GGGDTNTELH HHTYCCLLFF SPKKCN-CCP GGSTPPLLEA KK---GEEIL CCYYYYTTTE ---------- ---------- MAKKCN-CCP GGSTPPLLEA KK---GEEIL CCYYYYTTTE VVVQIMEGAA AAAVEEAAAA NGTTCHAKKP GGATPPLLEA EEKKKGEKLV CCYYYYTTIN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MKKCS-CCP GGKSPPLLDA KK---GEEIL CCYYYYTTIN -----MATVL LLDHGGVVEE KSVVNCKSSP GGASPPIIES SS---GESLV AAYYYYTTIE -----MGTVL LLQHAAVVEE VNQQQCKSSP GGASPPLLEA SS---GETLV AAYYYYTTIE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RLVGGP GGATPPLLAA SS---GEKLV AAYYYYTTID ---------- ------AAAA NGAACGATTP GGATPPLLEA EEKKKGEKLV CCYYYYTTIN ---------- ------MMPP CGKKCG---P GGASPPAADA KK---GEEVV AA----NNAD ---------- ------MM-- CPKKCG---P GGASPPAADA KK---GEEVV AA----HHRD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --SSEKKCCP GGATPPLLDA RRNNNGEKLV CCQQQQLLEE ---------- ---------- ---------- ---------- RRSSSGEKLT TTQQQQLLEP ---------- ---------- ---------P GGIT----DI IISSSLRFLS WWHHHHIIQY FFF------- ---ALLAA-- LAGGLFAFFD EECQSSPPYM KKIIITEEFV TTGGGGGGGD VVVGSMHFAL LLRALLSSLL LAAAAAVRRD EECASSPPYM KKIIITEDYV TTGGGGGGGD AIIVVDPSSS ETTYSSKIVV HHKKVEELLP YIDEEFGGWN AASSSSSSLL PPNGG-ERRR PLLVVDPSSS PTTYGGKVII YYKKLDDLLP YIDEEFGGWN AASSSSSSYY PPNAA-ERRR PLLVIDPSSS STTYGGKIVV HHTTVTTMMP NTDEEFGGWN AASSSSSSLL PPLTTGERRR PLLVIDPSSS PTTYGGQIVV HHTTVTTMMP NKDEEFGGWN AASSSSSSLL PPLAAGERRR PLLVVDPSSS EKKFGGQIVV HHQQLIIMMP NKDEEFGGWN AASSSSSSLL PPLTTGERRR PIIVVDPSSS PRRYAASIVV GGQQVAAMMP HADEEFGGWN AASSSSSSLL PPNAAPERRR PMMVVDSSSS STTFGGQVVV GGVVTDDMMP YTGEEFGGWN AASSSSSSLL PPNAAPERRR PLLVLDPSSS GTTYAAQIVV GGRRVEEMMP NADEEFGGWN AASSSSAALL PPYAAPERRR PLLTVDPSSS PQQYSSQVII HHRRLPPMMP YLDEESGGWN TTSSSSSS-- ---FFGSRRR PLLTVDPSSS PHHYSSQVII HHRRLPPMMP HLDEESGGWN TTSSSSSS-- ---FFGSRRR PLLTVDPSSS PQQYCCQVII HHRRLPPMMP NLDEESGGWN AASSSSSS-- ---FFGSRRR PLLTVDPSSS PQQYCCQVII HHRRLPPMMP HLDEESGGWN TTSSSSSS-- ---YYGARRR PLLTVDPSSS PQQYCCQVII HHRRLPPMMP NLDEESGGWN TTSSSSSS-- ---FFGSRRR PLLTVDPSSS PQQYCCQVII EE-------- ---------- ---------- ---------- PLLTVDPSSS PQQYCCQVII HHRRLPPMMP NLDEESGGWN TTSSSSSS-- ---FFGSRRR PLLTVDPSSS PQQYCCQVII HHRRLPPMMP NLDEESGGWN TTSSSSSS-- ---FFGSRRR PLLTVDPSSS PQQYSSQVII HHRRLPPMMP YLDEESGGWN TTSSSSSS-- ---FFGSRRR PLLTVDPSSS PQQYCCQVII HHRRLPPMMP NLDEESGGWN TTSSSSSS-- ---FFGSRRR PLLTVDPSSS PQQYCCQVII HHRRLPPMMP NLDEESGGWN TTSSSSSS-- ---FFGSRRR LLLTVDPSSS PTTYSSQVII HHRRLPPVVI HIDKKSGGWN SSSSSSSS-- ---HHGKRRR ---------- ---------- -------MMP NTDEESGGWN TTSSSSSS-- ---YYGVRRR PLLTVDPSSS PSSYSSQVII HHRRLPPMMP NVDEESGGWN TTSSSSSS-- ---YYGVRRR PLLTVDPSSS PTTYSSKVII HHRRLPPVVP YVDEETGGWN SSSSSSSS-- ---HHGERRR PLLTVDPSSS PTTYSSKVII HHRRLPPVVP YVDEETGGWN SSSSSSSS-- ---HHGQRRR ---------- ---------- -------MMP FVDEESGGWN SSSSSSSS-- ---HHGDRRR PLLTVDPSSS PSSYSSSVII HHRRLPPMMP FVDEESGGWN SSSSSSSS-- ---HHGDRRR PLLTVDPSSS PTTYSSQVII HHRRLPPVVT HVDEESGGWN AASSSSSS-- ---HHGSRRR PIITVDPSSS DTTFCCQVII SSRRVDDVVP HIDEETGGWN AASSSSSS-- ---HHDKRRR PIITVNPSSS ETTFCCQIII SSRRVDDVVP NIDEETGGWN AASSSSSS-- ---HHDKRRR ---------- ---------- ---------- ---------- ---------- ---------- GLLTVDPSSS PTTYCCQVII HHRRTYYTTN SKNEESGGWN TTSSSSSSHH PP-GGGTRRR GLLTVDPSSS PTTYCCQIVV HHRRTFFTTN RKDEESGGWN AASSSSSSYY DDESSSKRRR IRRNPRGVVV FLLGGGSVLL KKDDGPPVVK VLDKKSQQPT PPIIIILL-- -----GGGGG QLLTIDPSSS ATTRGGQVII NNSSVSSVVG G-NEEGGGFS AA-------- ------DRRR QLLTVDPSSS PQQYGGKVVV NNTTLSSVVG G-NEESDDFT DD-------- ------DRRR RFIVVVPGGL LLSSSRIIII ITKPPNPEPP PIIIIIKVVI EEPEKSSSRR LLTVVHHHGD RYIVVVPAAL LLSSSRIIIV VTKPPDKRPP PVVVVAKIIV EEPVGTTTKK YYTVVHHHGD RFIIIIPGGL LLSSSRIVVI ITKPPHPQAA AIIIIHKIII EEPEATTSRR PPTVVHHHGE RYIIIIPGGL LLSSSRIIII ITKPPDPKAA AIIIIHKIII EEPEKTTSRR PPTIIHHHGD RYIIIIPGGI IISSSRIIIV VVK--EPKAA AIIIIHKIII EEPEATTSRR PPTIIHHHGE RYVVVVPGGL LLSSSRIIIL LTKPPDPKPP PLLLLAKVVI EEPTETTSRR PPTVVHHHGG RYVVVVPDDI IISSSHIIIL LTKPPDPQPP PVVVVVKVVI DDPEETTARR PPTVVHHHGD RYIVVVPGGI IISSSRIIIV VTKPPDPEPP PIIIIVKVVI EEPERTTSRR PPTIIHHHGD RKILLLPGGL LLSSSRIVVV VVGSSEPAPP PLLLLHKVVI EEAEACCSNN TTTSSHHHLS RKILLLPSSI IISSSRIVVV VVGSSEPAPP PLLLLHKVVI EEPEACCGNN LLTSSHHHLS RKMLLLPCCL LLSSSRIVVV VVGSSDPAPP PLLLLHKVVI EEADACCGYY VVTSSHHHLS RKVLLLPAAL LLSSSRIVVV VVGTTEPAPP PLLLLHKVVI EEPDTCCGFF FFTSSHHHLS RKVLLLPSSL LLSSSRIVVV VVGSSEPAPP PLLLLHKVVI EEPDACCAFF LLTSSHHHLS ---------- ---------- ---------- ---------- --PDACCAFF LLTSSHHHLS RKVLLLPSSL LLSSSRIVVV VVGSSEPAPP PLLLLHKVVI EEPDACCAFF LLTSSHHHLS RKVLLLPSSL LLSSSRIVVV VVGSSEPAPP PLLLLHKVVI EEPDACCAFF LLTSSHHHLS RKVLLLPSSF FFSSSRIVVV VVGTTEPAPP PLLLLHKVVI EEADECCGTT PPTSSHHHLT RKVLLLPSSL LL-------- ---------- ---------- ---------- ---------- RKVLLLPSSL LLSSSRIVVV VVGSSEPAPP PLLLLHKVVI EEPDACCAFF LLTSSHHHLS RFILLLPSSL LLSGGRVVVV VTATTDPTPP PLLLLHKVVV EESDEIIGFF PPTSSHHHLS RKILLLPCCL LLSSSRIVVV VVGTTDPAPP PIIIIHKTTV EEPEWCCANN LLTSSHHHLC RKILLLPCCL LLSSSRIVVV VVGSSDPAPP PIIIIHKTTV EEPEWCCANN PPTSSHHHLC RFIAAAPSSL LLSGGRIVVI ITKTTNPSPP PLLLLHKVVV DDPDQTTAYY PPTSSHHHLS RFIVVVPGGI IISGGRVVVI ITKTTNPAPP PLLLLHKVVV EEPDTTTAYY PPTSSHHHLS RYVLLLPSSL LLSGGRIAAI ITKEENPAPP PLLLLYKYYV DDPEETTAYY PPTAAHHHLS RYVLLLPSSL LLSGGRIAAI ITKEENPAPP PLLLLYKYYV DDPEDTTAFF PPTAAHHHR- RFILLLPSSL LLSGGRVVVV VTLKKDPAPP PLLLLHKVVV EEADETTGFF PPTSSHHHLS RHIVVVPCCL LLSDDRIIII IVENNE-KII ILLLLEHTTI EEPKSNNSFF PPTSSHHHLD RHIVVVPCCL LLSDDRIVVI IVENNE-EII ILLLLQHTTI EEPKANNSFF PPTSSHHHLD --VPPPRKKL LLSGGVEKKV VVGGG----- ---------- ---------- ---------- RRVLLLPCCL LLSDDRIVVI ITGTTDPAPP PLLLLAKVVI EEGDKAATAA PPTTTHHHLN RRVLLLPSSL LLSDDFIIIL LVVTTDPKPP PIIIIVKTTI DDGDKHHTAA PPTTTHHHLN GQLQQQLSSL LLGKKRLVVT TSLYYSADKK KFFFFYP--- ---DKLLAII SSTAADDDQN RFWTTTGGGL LLTNNRIIIF FVHSSDPNPP PLLLLHKTTI DDTFDGGVGG PPTFFFFFLG RYWAAAGGGL LLTSSKIVVF FVHSSDPRPP PLLLLSKTTI TTDFKGGVGG PPTLLYYYLG AIIALLGGGG NN-EEG--EG PGGMLLHFEP PPKEIGGYY- ---------- -------LDD AIIALLGGGG GG-DDGRREG PGGLLLHFEP PPREVGGYY- ---------- -------FDD GVVTLLGGGG GGKDDGTTDG AGGIMMCFDV VVREIGGDD- ---------- -------KDD GVVTLLGGGG GGKDDGTTNG PGGIMMCFEV VVREIGGTT- ---------- -------LDD GVVTLLGGGG GGEDDGTTDG PGGILLCFEI IIREMGGTT- ---------- -------KDD GVVALLGGGG NN-EEG--KG PGGMLLAFEP PPREVGGYY- ---------- -------FDD GIIALLGGGG SS-EEG--EG PGGILLHLEV VVREIGGYY- ---------- -------LDD GVVALLGGGG SS-EEG--DG PGGVMMHFDP PPREVGGQQ- ---------- -------LDD GMMNTTLLLL GG-LLQGGNG KSSLLLGFEV VVTEKGGPP- ---------- -------MDD GMMSSSLLLL GG-PPQGGNG KGGLLLGFEV VVTEKGGPP- ---------- -------MDD GMMSTTLLLL GG-SSKGGNG KGGLLLGFEV VVTEQGGPP- ---------- -------MDD GMMSTTLLLL GG-PPEGGNG KGGLLLGFEV VVTEQGGPP- ---------- -------LDD GMMSSSLLLL GG-VVKGGNG KGGLLLGFEV VVTERGGPP- ---------- -------SDD GMMSSSLLLL GG-VVKGGNG KGGLLLGFEV VVTERGGPP- ---------- -------LDD GMMSSSLLLL GG-VVKGGNG KGGLLLGFEV VVTERGGPP- ---------- -------LDD GMMSSSLLLL GG-VVKGGNG KGGLLLGFEV VVTERGGPP- ---------- -------LDD GMMSTTLLLL GG-PPKGGNG KGGLLLGFEV VVTERGGPP- ---------- -------MDD ---------- ---------- ---------- ---------- ---------- ---------- GMMSSSLLLL GG-VVKGGNG KGGVLLPLEC CC-------- ---------- ---------- GMMSCCLLLL GG-KKEGGNA ANNLLLDFNV VVRSNFFSS- ---------- -------KTT GMMSSSIIII GG-PPYGGNG KGGLLLGFEV VVNEAEEPP- ---------- -------FDD GMMSSSLLLL GG-PPCGGNG KGGLLLGFEV VVNEVEEQQ- ---------- -------FDD GMMSCCLLLL GG-KKDGGNA ENNLLLDFNV VVREKHHLL- ---------- -------FDD GMMSCCIIII GG-KKDGGNA ENNLLLDFNV VVREKHHLL- ---------- -------FDD GLLSCCLLLL GG-EEEGGNA KNNLLLDFNI IIREKHHLL- ---------- -------FDD GLLSCCLLLL GG-EEEGGNA KNNLLLDFNI IIREKIILL- ---------- -------YHH GMMSCCLLLL GG-KKEGGNA ANNLLLDFNV VVREKHHLL- ---------- -------FDD GMMSTTLLLL GG-AANGGTP SNNLLLGFEP PPTPAKKPP- ---------- -------FDD GMMSTTLLLL GG-AADGGSP SNNLLLGFEP PPTPAKKPP- ---------- -------FDD ---------- ---------- ---------- ---------- ---------- ---------- GMMSIIMMMM GG-AAEGGNA K--VEEDFEL LLTSRRRLL- ---------- -------CDD GMMSVVMMMM GG-AAEGGYA K--ILLDFNC CCTTKKKLL- ---------- -------CDD TKKDGGVVVV NN-SSLSSVP VNNQTTKNGL LLKEAFFII- ---------- -------LSS SIIGLLSSSS NN-DDDHHGG RAAEYYDEYV VVYMPDDQQG GAAAAAVVDD AAAVVAGYDD RIIGLLSSSS NN-KKDHHGG RAAEYYNEYV VVHIPGGRRG GAKKKKTT-- KKKYYAGYDD DFWWNL-PEE LVSEEWWAAV PIEED--LLL KKLHHLLLKD D--NRFLLLK RRRKKILTTT DFWWNL-PGG MISEEWWTTV PFEEE--FFF SSLCCLLLKE EGGNKVLLLK RRRRRLIDDD DFWWNL-PDD MVSEEWWAAL PFEEN--III VVPDDLLLLA ANNHRFLLLA RRRRRVIDDD DFWWNL-PDD MVSEEWWAAL PFEEN--III VVPDDLLLLS SNNHRFLLLA RRRRRVIDDD DFWWNL-PDD MVSEEWWGGL PFEEN--III VVPDDLLLLS SNNHKFLLLD RRRKKVIDDD DGWWHL-GDD LVSEEWWGGT PVEED--LLL VVPIILLLLG GAARRFLLLR RRRRRLIDDD DFWWHL-GDD LLSEEWWGGT PVEES--VVV LLGEELLLLA AGGHRVLLLR RRRRRLLDDD DFWWHL-GDD MVSEEWWGGT PIEEG--LLL DDPIILLLLN NKKRRILLLR RRRRRLLDDD DFWYQP-RNN MVTEEWWAAA PFKKDFFNNN PPAVVEEEA- -GGSRVWWWR HHHEEILQQQ DFWYQP-RNN MVTEEWWAAA PFKKDFFNNN PPAVVEEEA- -GGSHVWWWR HHHEEILQQQ DFWYQP-RNN MITEEWWAAA PFRRDFFNNN PPAVVEEEA- -GGSHVWWWR HHHEEILTTT DFWYQP-RNN MITEEWWAAA PLRRDFFNNN PPAVVKKKA- -GGSHVWWWR RRREEVLPPP DFWYQP-RNN MITEEWWAAA PLRRDFFNNN PPAVVEEEA- -GGSHVWWWH HHHEEVLSSS DFWYQP-RNN MITEEWWAAA PLRRDFFNNN PPAVVEEEA- -GGSHVWWWR HHHEEVLSSS DFWYQP-RNN MITEEWWAAA PLRRDFFNNN PPAVVEEEA- -GGSHVWWWR HHHEEVLSSS DFWYQP-RNN MITEEWWAAA PLRRDFFNNN PPAVVEEEA- -GGSHVWWWR HHHEEVLSSS DFWYQP-RNN MITEEWWAAA PVQQNFFNNN PPAVVEEEA- -GGKHVWWWR HHHEEVLLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AIISSAAH SRLLTSSRRR DDYAASSSA- -SSGI----- ---------- THLYENYAGG FWWIIQQCCC SYTTTAAEEE LLMLLTTTA- -SSVILYYYM RRRVVDLPPP DFWYQP-RNN MITEEWWGGA PFAALFFKKK MMEVVQQQA- -GGHSVWWWE HHHRRIIDDD DFWYQP-RNN MITEEWWGGA PFAALFFKKK MMEVVQQQA- -GGHSVWWWE HHHRRVIDDD DFWYQP-RNN MITSSWWGGA PFTTKFFDDD LLQVVAAAD- -GGRHCLLLR GGGEERLDDD DFWYQP-RNN MITSSWWGGA PFLLQFFNNN LLQVVAAAD- -GGRHVWWWG GGGEEKLDDD DFWYQP-RKK MITSSWWGGA PFSSKFFDDD LLQVVAAAD- -GGSHVWWWG GGGEEKIDDD HFWYQP-RKK MITSSWWGGA PFSSKFFNNN LLQVVAAAD- -GGSHVWWWG GGGEEKIDDD DYWYQP-RKK MISSSWWGGA PFRRTFFDDD LLQVVQQQD- -GGRHVWWWG GGGEEKLDDD DFWYQP-RNN MITEEWWGGS PIKKKFFNNN PPAVVGGGE- -GGNSIWWWS KKKKKLIDDD DFWYQP-RNN MITEEWWGGS PIKKKFFNNN PPAVVPPPE- -GGNSIWWWT KKKKKLIDDD ---------- --ILLRRGGG PVCCREEEEE LLKQQPPPE- -PPKCV---- ---------- DYWYQP-HNN MVSEEWWGGA PFRRRYYHHH PPTCCDDDDR RTTCRFWWWE RRREEFIDDD DFWYQP-YDD MVSEEWWGGA PWRRRWWKKK NNVLLEEEDM MSSCRFWWWT QQQTTYIDDD SNHNNG--EE SEDRRPPDDE PAFFESSEEE SSFKKKKKTG GPPQHE---- ---------- DIRALI-RNN MLSSSFFTTG WMDDFQQMMM LLQAAEEEAM MKKNTQLLLT RRRQQKFNNN DVRALP-RNN LVSSSFFTTG WMDDFKKMMM LLAPPEEEAM MKKNTTLLLT KKKQQKFDDD LLGGRMAL-E LRRRPPLHHH DTTKGGGFIN NNNMVVVSLS SSSSSSSLY- GNNAEKKEIA LLGGRMVL-E VRRRPPLHHH DTTKGGGFVN NNNVVLLNTS SSSSSSSLY- GQQAERRDIA LLGGQMAL-E VRRRPPAHHH DVVRGGGFVG GGGVVVVDTE EEEGSSSTR- GHHVKKKTIA LLGGQMAL-E VRRRPPAHHH DVVRGGGFVG GGGVVVVDTE EEEASSSTR- GHHAEKKTIP LLGGQMAL-E IRRRPPAHHH DSSKGGGFCG GGGVVVVDTQ QQQGAAATQK GEEAKKKTIP FFGGQLVF-E LRRRPPAHHH DTTKGGGFVN NNNCVIISLS SSSSSSSTR- DAAVRKKEIA LLGGQMAL-E LRRRPPAHHH DTTKGGGFMN NNNCVVVSLS SSSASSSLR- GHHLKKKDIA VVGGQMVL-E LRRRPPAHHH DAARGGGFVG GGGVVVVSLS SSSASSSLR- GGGIRKKEIA MMTTGLIP-E IRRRFFLHHH DSSAGGGFVG GGGCALLSSR RRRFYYYE-- -------WSE MMKKGLIP-E IRRRFFLHHH DDDAGGGFVG GGGCALLSSR RRRFYYYE-- -------WSE LLQQGLIP-E IRRRFFLHHH NDDAGGGFVG GGGCALLSSR RRRFYYYQ-- -------WSE LLQQGLIP-E IRRRFFLHHH NDDAGGGFVG GGGCALLSSR RRRFFFFE-- -------WSQ LLKKGLIP-E IRRRFFLHHH NDDAGGGFVG GGGCALLSSR RRRFYYYE-- -------WSE LLKKGLIP-E IRRRFFLHHH NDDAGGGFVG GGGCALLSSR RRRFYYYE-- -------WSE LLKKGLIP-E IRRRFFLHHH NDDAGGGFVG GGGCALLSSR RRRFYYYE-- -------WSE LLKKGLIP-E IRRRFFLHHH NDDAGGGFVG GGGCALLSSR RRRFYYYE-- -------WSE MMPPGHIP-E IRRRFFLHHH DAAAGGGFVG GGGCALLSSR RRRFYYYE-- -------WSE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLQQQAGANC LRRRSSIHHH WNNIDDDYDV VVVVEVVSFG GGGGSSSD-- -------VVK LLGGGLIP-E IRRRFFLHHH DDDAGGGLVG GGGCALLSSR RRRFYYYK-- -------WAE LLGGGLIP-E IRRRFFLHHH NDDAGGGLVG GGGCALLSSR RRRFYYYK-- -------WAE LLGGGLLP-E IRRRFFLHHH DAAKGGGFVG GGGSALLSSR RRRFFFFQ-- -------WSE LLGGGLLP-E IRRRFFLHHH DAAKGGGFVG GGGSALLTSR RRRFFFFQ-- -------WNE LLGGGLLP-E IRRRFFLHHH DSSKGGGYVG GGGSALLSSR RRRFFFFS-- -------WSE LLGGGLLP-E IRRRFFLHHH DSSKGGGFVG GGGSALLSSR RRRFFFFS-- -------WSE LLGGGLLP-E VRRRFFLHHH DSSKGGGYVG GGGCALLTSR RRRFFFFA-- -------WSE LLPPGALP-E VRRRFFLHHH ETTSAAAFVG GGGCALLGSR RRRIHHHES- -----TTHAT LLPPGALP-E VRRRFFLHHH ETTSAAAFVG GGGCALLGSR RRRIHHHEP- -----KKQTS ---------- ---------- ---------- ---------- ---------- ---------- LLGGGLTP-E IRRRFFLHHH NRREGGGYVG GGGCAFFXXX XXXXXXX--- ---------- LLGGGITP-E IRRRFFLHHH NKKKGGGFVG GGGCALLNAH HHHFKKKSD- -----EEAKV ---------- ---------- ---------- ---------- ---------- ---------- VVPP-----E IRRRFFPWWW GNNAAAAFST TTTTALLTSL LLLIYYYD-- ---------- VVPP-----E IRRRCCAWWW GAAHCCCFTS SSSTALLTSL LLLIYYYG-- ---------- EPPLLE-ILF FKALVVTDDS SSSDKFLYSS LWWIGVRQQY YYSSNPKPLV LLLGGIHAAD QPPFFE-VLF FKMLVVTDDS SSSDRFLYSS LWWLGLRQQY YYTTNPQPLV IIIGGLHEEP EPPAATDLLF FGALVVTDDS SSSDRFLYSS CWWTGMRQQY YYSSDPNPLV IIIGGIRAAP EPPAAPELLF FGALVVTDDS SSSDRFLYSS CWWTGMRQQY YYSSDPKPLV IIIGGIRTTP VPPAADDLLF FGALVVTDDS SSSDKYLYAA CWWLGMHQQY YYSSDPNPLV IIIGGIKTTP EAAAADDVLF FKALVVTDDS SSSDRFLYSS CWWTGLLQQY YYSSDPEPLV IIIGGISAAT EPPAASDILF FKALVVTDDS SSSDRFLYSS CWWTGLHQQY YYSSDPNPLV IIIGGIRAAG EPPAAEDLLF FGALVVTDDS SSSDRFLYSS CWWTGLRQQY YYSSDPNPHV LLLGGIRAAA KVVIIQPKGL LPELIITDDS SSSDRFLYSS NWWHGIRQQY YYSSNPKPLI LLLGGSVGGG KVVIIQPKGL LPELIITDDS SSSDRFLYSS NWWHGIRQQY YYSSNPKPLI LLLGGSVGGG KVVIIQPKGL LPELIITDDS SSSDRFLYSS NWWHGLRQQY YYSSDPRPLL LLLGGSVGGG KVVIIQPKGL LPELIITDDS SSSDHFLYSS NWWHGIRQQY YYSSDPRPLL LLLGGSVDDG KVVIIQPKGL LPELIITDDS SSSDRFLYSS NWWHGLRQQY YYSSDPRPLL LLLGGSVGGG KVVIIQPKGL LPELIITDDS SSSDRFLYSS NWWHGLRQQY YYSSDPRPL- ---------- KVVIIQPKGL LPELIIT--- ---------- ---------- ---------- ---------- KVVIIQPKGL LPELIITDDS SSSDRFLYSS NWWHGLRQQY YYSSDPRPLL LLLGGSVGGG KVVIIEPKGL LPELIITDDS SSSDRFLYNN NWWHGMRQQY YYSSDPRPLI LLLGGSVGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RKKLLDYAKV VVSEFFPPPF FFFDLLIILL S--------- ---------- ---------- KVVIIKPEGL LPELIITDDS SSSDRFLYSS NWWHGIRQQY YYTTDPNPLI LLLGGSLGGG KVVIIQPEGM MPELIITDDS SSSDRFLYSS NWWHGIRQQY YYTTDTNPLI LLLGGSQGGG LAAIIPKQNL LPELIITDDS SSSDRFLYVV NWWHGIRQQY YYEEDLNPLL VVVGGLQGGS IVVIISEQNL LPELIITDDS SSSDRFLYVV NWWHGIRQQY YYEEDVNPLV AAAGGLQGGS IVVIISKENL LPELIITDDS SSSDRFLYVV NWWHGIRQQY YYEEDPNPLI VVVGGLQGGS VVVIISKENL LPELIITDDS SSSDRFIYVV NWWHGIRQQY YYEEDPNPLI VVVGGLQGGS VAAIISKRNL LPELIITDDS SSSDRYLYVV NWWHGIRQQY YYEEDPKPLV AAAGGLQGGS LVVAAFPSGL LPELIITDDS SSSDRFLYSS CWWHGIRQQY YYSSDPKVLV IIIGGSHEES LVVAATPENL LPDLIITDDS SSSDRFLYSS CWWHGIRQQY YYSSDPNPLV IIIGGSHEET ---------- ---------- ---------- ---------- ---------- ---------- -------ENI IEMMMMTDDS SSSDRYLYSS NWWHGVRQQY YYSSDRNPLV LLLGGAQDDA IDDIIPKGSA AEDMIISDDS SSSDRFLYNN CWWHGVRQQY YYTTDPNPLL LLLGGACDDL ---------- ---------- ---------- ---------- ---------- ---------- -----EQADN NPALPPVDDA AAADQTLWNN SFFDGTRLLF FFSSDPKPQK IIIRRQN--- -----EQADE EPALPPVDDS SSSDSRLWNN TFFDGTRLLF FFSSDPHPQK IIIAAQN--- HPP------- ---------- ----GKLLLL LTTTGMEIRD GRYYVNNSLS SSTTWDFPPL HPP------- ---------- ----GEAAAA ATTTGMSVRD GRYYINNSLS SSSSWNFPPL HPP------- ---------- ----GTFFFF FAAAGMEIRD GRYYWNNSLS SSTTWDFPPV HPP------- ---------- ----GAFFFF FAAAAMEIRD GRYYWNNSLS SSTTWDFPPV HPP------- ---------- ----GTFFFF FGGGYMEIRD GRYYWNNSLS SSTTWDFPPR HPPGG----- ---------- ---ANALLLL LNNNGMEIRD GRYYFNNSLG GGAAVDFPPI HPP------- ---------- ---ASELLLL LNNNGMEIRD GRYYFNNSLR RRAAWDFPPI HPP------- ---------- ----SPLLLL LNNNGMEVRD GRYYFNNSLA AASSWDFPPI SVVQQEEEDD DDEEELTTPL VVVVGRIIII IPPPGMQLLD GRYYATTSLS SSDDWDF--L SVVQQEEEDD DDEEELTTPL VVVVGRVVVV VPPPGMQLLD GRYYVTTSLS SSAAWDF--L PVVQQEEEDD DDEEELKKPL VVVVGKVVVV VPPPGMQLLD GRYYVTTSLS SSAAWDF--L PVVQQDDDDD DDEEELDDPL VVVVGQVVVV VAAAGMQLLD GRYYVTTSLS SSAAWDF--L PVVQQEEEDD DDEEELKKPL VVVVGRVVVV VAAAGMQLLD GRYYITTSLS SSAAWDF--L ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PVVQQEEEDD DDEEELKKPL VVVVGRVVVV VAAAGMQLLD GRYYITTSLS SSAAWDF--L PVVQQEEEDD DDEEELKKPL VVVVGRVVVV VPPPGMQLLD GRYYVTTSLS SSDDWDF--L ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PVVTTEEEDD DDDDDLEEPV IIIVGKVVVV VPPPGMQLLD GRYYVNNSLS SSKKWDF--M PVVTTEEEDD DDEEELEEPV TTTVGIIIII IPPPGMQLLD GRYYVSSSLS SSIIWDF--L PVVAAGGGEE EEGGGKTTVP EEEIGKLLLL LRRRGMQLLD GRYYVNNSLS SSAAWDF--L PVVVVKKKDD DDGGGETTVP EEEIGKLLLL LRRRGMQLLD GRYYVNNSLS SSAAWDF--L PVVKKGGGEE EEGGGNSSVP QQQIGSLLLL LRRRGMQLLD GRYYANNSLS SSAAWDF--L PVVKKGGGEE EEGGGNTTVP QQQIGSLLLL LRRRGMQLLD GRYYANNSLS SSAAWVF--I EVVVVTTTEE EEDDDKEEVP QQQVGRLLLL LRRRGMQLLD GRYYVNNSLS SSRRWDFGGL NVVKKEEEGG GGKKK---AL YYYVGKIIII IEEEGMQLLD GRYYVTTSLK KKKKWDF--H TVVKKEEEEE EEHHHD--AL YYYVGQIIII IEEEGMQLLD GRYYVTTSLK KKKKWDF--N ---------- ---------- ---------- ----GKQLVD GRYYVNNSFS SSTTWDF--V PRRRRNNNDD DDEEELKKPV FFFLGRLLLL LLLLGMQLLD GRYYVSSSLS SSPPWDF--M PNNVVKKKDD DDEEELKKAR YYYVGRLLLL LEEEGMQLLD GRYYVSSSLS SSPPWDF--M ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MSQWD GRYYFSSSLA AANNWD---- ---------- ---------- ---------- -----MSSWD GRYYYSSSLA AANNWD---- KKGKA----- -PPPSLEDDE EEFF------ ASSHHHHQVV LLSSGAASDS SSSYYYPP-- RRGKV----- -PPPELEEEE EEFF------ AAAHHHHQVV LLWWGAASDS SSSFFFPP-- PPALA----- -PPPDLTAAD DDYWG----- YAAHHHHQII LLEEGCCSDS SSSFFFPPSV PPGMV----- -GGGNLEDDD DDYFG----- YAAHHHHQII LLEEGCCSDS SSSFFFPPSV GGAMV----- -EEENLTDDD DDFWG----- YSSHHHHQII LLEEGCCSDS SSSFFFPPSV DDGKA----- -PPPNIEDDK KKFFG----- HPPHHHHQVV LLQQGCCSDS SSSYYYPP-- KKGKV----- -PPPDMQDDN NNFF------ QVVHHHHQII LLQQGAASDS SSSYYYPP-- RRGKA----- -PPPGLSDDG GGFFG----- LPPHHHHQII LLEEGSSSDS SSSYYYPPS- IIRVQDDVVV TVVVNLKNNN NNFLEPPPLP AAAHHHHELL YYPPGCCSDI IIIWWW---- IIRVQDDVVV TAAANLKNNN NNFLEPPPLP AAAHHHHELL YYPPGCCSDI IIIWWW---- IIRVQDDVVV TVVVKLKNNN NNFLEPPPLP AAAHHHHELL YYPPGCCSDI IIIWWW---- IIRVQDDVVV TVVVKLTNNN NNFLEPPPLP AAAHHHHELL YYPPGCCSDI IIIWWW---- IIRVQDDVVV TVVVKLKNNN NNFLEPPPLP AAAHHHHELL YYPPGCCSDI IIIWWW---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIRVQDDVVV TVVVKLKNNN NNFLEPPPLP AAAHHHHELL YYPPGCCSDI IIIWWW---- IIRVQDDVVV TVVVKLKNNN NNFLEPPPLP AAAHHHHEII YYPPGCCTDI IIIWWW---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIKVQDDVVV TEEEKLKNNN NNFLEPPPGP VAAHHHHELL YYPPGCCSDI IIIWWW---- LLKVQDDVVV TKKKKLKNNN NNFLEPPPDP VAAHHHHEII YYPPGCCTDI IIIWWW---- VVEHQDDVVV TEEEKLKNNN NNFFEPPPDP AAAHHHHEMM YYPPGCCTDI IIIWWW---- VVEHQDDVVV TEEENLKNNN NNFFEPPPDP SAAHHHHEMM YYPPGCCTDI IIIWWW---- MMDHQDDVVV TEEEKLSNNN NNFFEPPPEP AAAHHHHEMM YYPPGCCTDI IIIWWW---- MMEHQDDGGG TEEEKLTNND DDFFEPPPDP SAAHHHHEMM YYPPGCCTDI IIIWWW---- VVKHQDDVVV TEEEKLSNNN NNFFEPPPEP SAAHHHHEMM YYPPGCCTDI IIIWWW---- VVKTQNNIII PEEESMENND DDFLIEEEGP YAAHHHHEMM YYPPGCCTDI IIIWWW---- VVRTQDDVVV PIIITMVNNN NNFLVPPPGP YAAHHHHEMM YYPPGCCTDI IIIWWW---- VVKVQDDVVV TEEEKLTNNN NNFLEPPPNP CAAHHHHDII FFPPGSSTDI IIILLL---- VVATQDDIII VEEENMKNNN NNFLEPPPYP GPPHHHHEMM ---------- ---------- VVSHLDDVVV TVVVNISNND DDFLEPPPYP SPPHHHHEMM YYPPGCCTDI IIIWWWNNDA ---------- ---------- ---------- ---------- ---------- ---------- --KDQLLKKK YNNNWKEVVD DDFALGGGL- -AAHHHHIMM FFGGSLLYS- ---------- --KDQLLKKK YYYYWKEKKQ QQFAEKKKL- -PPHHHHQMM FFGGRLLYGP PPPAAAGGNR ------- ------- KKKR--- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLLVARE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSAKKKKQ PEETPPPPAV GGAAAAADDA AMQQSSRRTT AALLLSSLPP GPPIIKAAAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- --------RS gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAWTFFSAQS SPRSSSESGR KKKKTRRVVG LVEISSAAVQ AAVQQQAHWL PKHHGGAALI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAEEGGFFLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MGL GEPPGGTTQP ---------- ---------- ---------- ---------- ------LKNS QLGGFFQQNT ---------- ---------- ---------- ---------- ---------- ---------- SSAPTTLPNP PPHPPPNPAP AAAASPPHHR VPLTRLVPIP PRLPPPPPHA RLVVLLHHME ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MA ---------- ---------- ---------- ---------- ---------- --------MG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M KEFFGG---- ---------- ---------- ---------- ---------- ---------M KIVVSSPPMH ---------- -MAFFKKRRD DDPPKKMMAA PPPPLAYCCT TTGGINRRRA DDFFAAADVN ---------- ---LLKKPPD DDPPRRDDAA PPPPIAYAAV TTGGVNAAAP DDFFAAADVD ---------- ---MMRRPPD DDPPEELLAA PPPAFAYLLP FFSS--RRRP DDAAAAADVK ---------- ---MMRRPPD DDPPKKLLAA PPPAFAYLLP FFSS--KKKP DDAAAAADVK ---------- ---LLRRPPD DDPPKKLLAG PPPVLAFMMP AASS--KKKP DDGGAAADVD ---------- ---WWKKPPD DDPPRRLLAA PPPPIAYMMP RRKK--QQQP DDAAAAADVD ---------- ---WWRRPPD DDPPRRMMAA PPPALAYRRP AANNG-KKKP DDAACCCDVD ---------- ---WWRRPPD DDPPKKMMAA PPPRLGYLLP RREE--RRRP DDAAGGGDLD ---------- ATK----CCG GGPPEEAAMG PPPRIVYCCR TTGGTEAAAP DDYYAAADVD ---------- ---------- ---------G PPPRIVYCCR TTGGIEAAAP DDYYAAADVD APPRRLLP-A STQ----CCG GGPPEEAAMG PPPRIVYCCG TTGGIEAAAP DDYYAAADID ---------- ---------- --------MG PPPRIIYCCR TTGGIEAAAP DDYYAAADVD ---------- ATK----CCG GGPPEEAAMG PPPRIVYCCR TTGGTEAAAP DDYYAAADVD SVVQQRRPAS ATK----CCG GGPPEEAAMG PPPRIVYCCR TTGGTEAAAP DDYYAAADVD ---------- ATK----CCG GGPPEEAAMG ---------- ----TEAAAP DDYYAAADVD ---------- ATK----CCG GGPPEEAAMG PPPRIVYCCR TTGGTEAAAP DDYYAAADVD WFFSSLLWED ATK----CCG GGPPEEAAMG PPPRIVYCCR TTGGTEAAAP DDYYAAADVD ELLTTTTLFT PTK----CCG GGPPEEAAMG PPPRIVYCCR TTGGTEAAAP DDYYAAADVD ---------- ATK----CCG GGPPEEAAMG PPPRIVYCCR TTGGTEAAAP DDYYAAADVD GAAAATTAAA GKTTTAAKKG GGPPEEAAMG PPPRLVYCCN TTGGINKKKL DDYYAAADLD ---------- ---------- ---------- ---------- ---------- ---------- ---------- MAK----CCG GGPPDDAAMG PPPRIVYCCR TTGGINKKKP DDYYAAADVD TVVDDVVVEK S-VCCKKSSG GGPPEESSMG PPPRLIYAAA TTGGIEKKKP DDYYAAADVD TVVQQVVVEK NNQCCKKSSG GGPPEEAAMG PPPRLIYAAA TTGGIEKKKP DDYYAAADLD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---QQVVGGG GGPPAAAAMG PPPSLIYAAT TTGGIDKKKP DDYYAAADVD -----MMAAA GAAGGAATTG GGPPEEAAMG PPPRLLYCCN TTGGINKKKP DDYYGGGDVD -------MPN GLK------G GGPPDDAAIG PPPRVLFAA- NNAAADGGGP DDAAFFFDVN -------M-- PLK------G GGPPDDAAIG PPPRVLFAA- HHAARDGGGP DDAAFFFNVN ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MSCCKKCCG GGPPDDAAVG PPPVLLYCCP LLDDEEHHHG DDYYAAADVD ---------- ---------- --------MG PPPRLLYTTP LLDDEPHHHG DDYYSSSDVD ---------- ---------M MMPPDDIILL DDDDLYFWWG IIRRQYDDDI TTDDKKKRMV -----AAA-A AMGRRAAFFA AADDYYMMPT GGGQFVYTTV GGMMGDEEEQ DDKKVVVDLR FAARRVVSLA ALAGGVVRRA AADDYYMMKT GGGQYVYTTA GGVVGDEEEQ DDKKVVVDAN PPKSETYSKI IIHHHKVVLY YINEFFGGNA CCSSAC-NKK KEERRFFLIV PGLLLSYYII PPKSPTYGKV VVYYYKLLLY YIGEFFGGNA CCSSAC-NKK KEERRYYLIV PALLLSYYVV PPGSSTYGKI IIHHHTVVMN NTGEFFGGNA CCSSSS-LHH HEERRFFLII PGLLLSYYII PPGSPTYGQI IIHHHTVVMN NKGEFFGGNA CCSSAS-LHH HEERRYYLII PGLLLSYYII PPTSEKFGQI IIHHHQLLMN NKGEFFGGNA CCSSAS-LHH HEERRYYLII PGIIISYYVV PPASPRYASI IIGGGQVVMH HAGEFFGGNA CCSSCC-NHH HEERRYYLVV PGLLLSYYLL SSQSSTFGQV VVGGGVTTMY YTGEFFGGNA CCSSMC-NHH HEERRYYLVV PDIIISTTLL PPDSGTYAQI IIGGGRVVMN NAAEFFGGNA CCSAAC-YHH HEERRYYLIV PGIIISHHVV PPKSPQYSQV VVHHHRLLMY YLKESSGGNT CCSSC---DD DSSNNKKLIL PGLLLSYYVV PPKSPHYSQV VVHHHRLLMH HLKESSGGNT CCSSC---DD DSSDDKKLIL PSIIISYYVV PPKSPQYCQV VVHHHRLLMN NLRESSGGNA CCSSC---DD DSSTTKKLML PCLLLSYYVV PPKSPQYCQV VVHHHRLLMH HLKESSGGNT CCSSC---DD DAATTKKLVL PALLLSYYVV PPKSPQYCQV VVHHHRLLMN NLKESSGGNT CCSSC---DD DSSTTKKLVL PSLLLSYYVV PPKSPQYCQV VVEEE----- ---------- ---------- ---------- ---------- PPKSPQYCQV VVHHHRLLMN NLKESSGGNT CCSSC---DD DSSTTKKLVL PSLLLSYYVV PPKSPQYCQV VVHHHRLLMN NLKESSGGNT CCSSC---DD DSSTTKKLVL PSLLLSYYVV PPKSPQYSQV VVHHHRLLMY YLKESSGGNT CCSSC---DD DSSNNKKLVL PSFFFSYYVV PPKSPQYCQV VVHHHRLLMN NLKESSGGNT CCSSC---DD DSSTTKKLVL PSLLL----- PPKSPQYCQV VVHHHRLLMN NLKESSGGNT CCSSC---DD DSSTTKKLVL PSLLLSYYVV PPSSPTYSQV VVHHHRLLVH HIGKSSGGNS CCSSC---DD DKKRRFFLIL PSLLLGYYVV ---------- --------MN NTNESSGGNT CCSSC---DD DVVNNKKLIL PCLLLSYYVV PPKSPSYSQV VVHHHRLLMN NVNESSGGNT CCSSC---DD DVVNNKKLIL PCLLLSYYVV PPSSPTYSKV VVHHHRLLVY YVGETTGGNS CCSSC---DD DEERRFFLIA PSLLLGYYII PPNSPTYSKV VVHHHRLLVY YVGETTGGNS CCSSC---DD DQQRRFFLIV PGIIIGYYII ---------- --------MF FVGESSGGNS CCSSC---DD DDDRRYYLVL PSLLLGYYII PPSSPSYSSV VVHHHRLLMF FVGESSGGNS CCSSC---DD DDDRRYYLVL PSLLLGYYII PPNSPTYSQV VVHHHRLLVH HVGESSGGNA CCSSC---DD DSSRRFFLIL PSLLLGYYVV PPESDTFCQV VVSSSRVVVH HIGETTGGNA CCSSC---KK KKKSSHHLIV PCLLLDYYII PPESETFCQI IISSSRVVVN NIGETTGGNA CCSSC---KK KKKSSHHLIV PCLLLDYYII ---------- ---------- ---------- ---------- -------MVP RKLLLGGGVV PPASPTYCQV VVHHHRTTTS SKHESSGGNT CCSSCFV-KK KTTDDRRLVL PCLLLDFFII PPESPTYCQI IIHHHRTTTR RKGESSGGNA CCSSCYVEKK KKKDDRRLVL PSLLLDYYLL GGQVFLGGSV VVKKKDGGVV VLEKSSQQTP RRILK---KK KGGPPQQMLQ LSLLLKYYTT PPGSATRGQV VVNNNSVVVG G-REGGGGSA ---------- -DDRRFFFWT GGLLLNFFFF PPKSPQYGKV VVNNNTLLVG G-RESSDDTD ---------- -DDRRYYLWA GGLLLSFFFF ITTKKPNNNP EEEPIIKVVI EPPEEEEEEE VKSSGGYSRL TVVHCGPAAG GGGE---GEP VTTKKPDDDK RRRPAAKIIV EPPEEEEEVV AGTTGGYTKY TVVHCGPAAG GGGP---GEP ITTKKPHHHP QQQAHHKIII EPPDDDDDEE IATTGGYSRP TVVHCGPGTG GGGAGGKGDA ITTKKPDDDP KKKAHHKIII EPPEEEEEEE VKTTGGYSRP TIIHCGPGTG GGGGGGKGNP VVVKK-EEEP KKKAHHKIII EPPEEEEEEE VATTGGYSRP TIIHCGPGTG GGGGGGEGDP LTTKKPDDDP KKKPAAKVVI EPPEEEEETT LETTGGYSRP TVVHCGPGAG GGGA---GKP LTTKKPDDDP QQQPVVKVVI DPPNNNNNEE LETTGGYARP TVVHCGPGAG GGGP---GEP VTTKKPDDDP EEEPVVKVVI EPPEEEEEEE LRTTGGYSRP TIIHCGPGAG GGGP---GDP VVVGGSEEEP AAAPHHKVVI EAASSSSSEE IACCNNVSNT TSSHCLAGNL LLLD---QNK VVVGGSEEEP AAAPHHKVVI EPPNNNNNEE IACCNNLGNL TSSHCLAGSL LLLD---QNK VVVGGSDDDP AAAPHHKVVI EAAEEEEEDD IACCGGLGYV TSSHCLAGSL LLLD---KNK VVVGGTEEEP AAAPHHKVVI EPPKKKKKDD ITCCNNLGFF TSSHCLPGSL LLLD---ENK VVVGGSEEEP AAAPHHKVVI EPPEEEEEDD IACCEELAFL TSSHCLAGSL LLLD---KNK ---------- ---------- -PPKKKKKDD IACCEELAFL TSSHCLAGSL LLLD---KNK VVVGGSEEEP AAAPHHKVVI EPPKKKKKDD IACCEELAFL TSSHCLAGSL LLLD---KNK VVVGGSEEEP AAAPHHKVVI EPPKKKKKDD IACCEELAFL TSSHCLAGSL LLLD---KNK VVVGGTEEEP AAAPHHKVVI EAAKKKKKDD IECCGGLGTP TSSHCLPGSL LLLD---KNK ---------- ---------- ---------- ---------- ---------- ---------- VVVGGSEEEP AAAPHHKVVI EPPKKKKKDD IACCEELAFL TSSHCLAGSL LLLD---KNK VTTAATDDDP TTTPHHKVVV ESSEEEEEDD IEIIGGLGFP TSSHCLAGSL LLLD---ENA VVVGGTDDDP AAAPHHKTTV EPPYYYYYEE VWCCGGLANL TSSHCLGGSI IIID---YNK VVVGGSDDDP AAAPHHKTTV EPPYYYYYEE VWCCGGLANP TSSHCLGGSL LLLD---CNK ITTKKTNNNP SSSPHHKVVV DPPAAAAADD IQTTGGLAYP TSSHCLAGSL LLLD---DNE ITTKKTNNNP AAAPHHKVVV EPPEEEEEDD ITTTGGLAYP TSSHCLAGSI IIID---DNE ITTKKENNNP AAAPYYKYYV DPPKKKKKEE IETTGGLAYP TAAHCLAGSL LLLD---ENK ITTKKENNNP AAAPYYKYYV DPPKKKKKEE IDTTGGLAFP TAAHCRTGSL LLLD---ENK VTTLLKDDDP AAAPHHKVVV EAAEEEEEDD IETTGGLGFP TSSHCLAGSL LLLD---ENA IVVEENEEE- KKKIEEHTTI EPPSSSSSKK LSNN--LSFP TSSHCLAGSL LLLE---NTS IVVEENEEE- EEEIQQHTTI EPPSSSSSKK LANN--LSFP TSSHCLAGSL LLLE---DSS VVVGGG---- ---------- ---------- ---------- ---------- ---------- ITTGGTDDDP AAAPAAKVVI EGG-----DD VKAADDCTAP TTTHCLPGSM MMMD---ENK LVVVVTDDDP KKKPVVKTTI DGG-----DD VKHHNNVTAP TTTHCLAGSM MMMD---EYK TSSLLYSSSA DDDKYYP--- --------DD LKLLVVLAIS TAADYQPTDV VVVE---LVV FVVHHSDDDP NNNPHHKTTI DTT-----FF VDGGGGVVGP TFFFALPSGS SSSD---DGR FVVHHSDDDP RRRPSSKTTI TDD-----FF VKGGGGVVGP TLLYALPRGS SSSN---DGR PGGGGMMMLL DDYSFPPLGG GKEDRY---- ----LDFWWN N--EEVSSEA AVP---IG-- PGGGGLLLLL DDDTFPPIGG GREYRY---- ----FDFWWN N--GGITTET TVP---FG-- APPPGIIIMM DDETFVVLGG GREDRD---- ----KDFWWN N--DDVSSEA ALP---FG-- PPPPGIIIMM DDETFVVLGG GREDRT---- ----LDFWWN N--DDVTTEA ALP---FG-- PPPPGIIILL DDETFIILGG GREDRT---- ----KDFWWN N--DDVSSEG GLP---FG-- PGGGGMMMLL DDQSFPPLGG GREERY---- ----FDGWWH H--DDVTTEG GTP---VG-- PGGGGIIILL DDDNLVVLGG GREDRY---- ----LDFWWH H--DDLTTEG GTP---VG-- PGGGGVVVMM DDESFPPLGG GREERQ---- ----LDFWWH H--DDVTTEG GTP---IG-- KGGGSLLLLL DDETFVVKGG GTEPGP---- ----MDFYYQ Q--NNVSSEA AAP---FGFF KGGGGLLLLL DDETFVVKGG GTEPGP---- ----MDFYYQ Q--NNVSSEA AAP---FGFF KGGGGLLLLL DDETFVVKGG GTEPGP---- ----MDFYYQ Q--NNISSEA AAP---FGFF KGGGGLLLLL DDKTFVVKGG GTEPGP---- ----LDFYYQ Q--NNISSEA AAP---LGFF KGGGGLLLLL DDETFVVKGG GTEPGP---- ----SDFYYQ Q--NNISSEA AAP---LGFF KGGGGLLLLL DDETFVVKGG GTEPGP---- ----LDFYYQ Q--NNISSEA AAP---LGFF KGGGGLLLLL DDETFVVKGG GTEPGP---- ----LDFYYQ Q--NNISSEA AAP---LGFF KGGGGLLLLL DDETFVVKGG GTEPGP---- ----LDFYYQ Q--NNISSEA AAP---LGFF KGGGGLLLLL DDETFVVKGG GTEPGP---- ----MDFYYQ Q--NNISSEA AAP---VGFF ---------- ---------- ---------- ---------- ---------- ---------- KDDDGVVVLL LL-RLCCSGG G--------- ---------- --------IA AHS---RGSS AGGGNLLLLL LLSEFVVKGG GRSRLS---- ----KTHYYE EYYGGWSSIC CCS---YGAA KGGGGLLLLL DDETFVVKGG GNEEGP---- ----FDFYYQ Q--NNISSEG GAP---FGFF KGGGGLLLLL DDETFVVKGG GNEEGQ---- ----FDFYYQ Q--NNISSEG GAP---FGFF EGGGNLLLLL LLSDFVVKGG GREPGL---- ----FDFYYQ Q--NNISSSG GAP---FGFF EGGGNLLLLL LLSEFVVKGG GREPGL---- ----FDFYYQ Q--NNISSSG GAP---FGFF KGGGNLLLLL LLSDFIIKNN NREPGL---- ----FDFYYQ Q--KKISSSG GAP---FGFF KGGGNLLLLL LLSDFIIKNN NREPDL---- ----YHFYYQ Q--KKISSSG GAP---FGFF AGGGNLLLLL LLSEFVVKGG GREPGL---- ----FDYYYQ Q--KKISSSG GAP---FGFF SGGGNLLLLL DDKTFPPKGG GTPDEP---- ----FDFYYQ Q--NNISSEG GSP---IGFF SGGGNLLLLL DDKTFPPKGG GTPDGP---- ----FDFYYQ Q--NNISSEG GSP---IGFF ---------- ---------- ---------- ---------- ------SSLG GGP---VDEE KGGG-VVVEE FFKNFLLVGG GTSGDL---- ----CDYYYQ Q--NNVAAEG GAP---FGYY KGGG-IIILL FFSDFCCIGG GTTGDL---- ----CDFYYQ Q--DDVSSEG GAP---WGWW VLLLNQQQTT SSHENLLSAA AKESQI---- ----LSNNNN N--EEESSRD DEP---ASSS RTTTAEEEYY NNDGEVVATT TYMTAQVAVV GDDAYDIAAL L--NNLTTST TGWNNYMGQQ RTTTAEEEYY TTAGEVVATT THITDRIKTT G--KYDVAAL L--NNVTTST TGWNNYMGKK LLLEEHLLLD D---YNRIHH FLKRISLLTT LGEEEENMMA AALL---EEL PLLLDDPPTT FLLEECLLLE EGGGYNKLHH VLKRLAIIDD LGQQQEHMMV VVLL---EEV PLLLDDPPTT IPPEEDLLLA ANNNYHRLHH FLARVTIIDD LGAAAQHMMA AALL---EEV PAAADDPPVV IPPEEDLLLS SNNNYHRLHH FLARVTIIDD LGAAANHMMA AALL---EEV PAAADDPPVV IPPEEDLLLS SNNNYHKIHH FLDRVTIIDD LGAAANHMMA AALL---EEI PAAADDPPSS LPPDDILLLG GAAAYRRLHH FLRRLEIIDD FGDDDEHLLV VVFF---EEL PAAADDPPTT VGGDDELLLA AGGGYHRLHH VLRRLTLLDD LGAAAEYMMA AALL---EEL PAAADDPPTT LPPQQILLLN NKKKYRRLHH ILRRLALLDD VGEEEEHMMV VVLL---EEL PAAADDPPAA NAAHHVEEE- -GGGYSRIFF VWRHITLLQQ MT----DLLI IIPP-LLEEI FLLLDDPPSS NAAHHVEEE- -GGGYSHIHH VWRHITLLQQ MK----DLLI IIPP-LLEEI FLLLDDPPDD NAADDVEEE- -GGGYSHLHH VWRHITLLTT LQ----DLLI IIPP-LLEEI FLLLNNPPDD NAADDVKKK- -GGGYSHLYY VWRRVTLLPP LQ----DLLI IIPP-LLEEI FLLLNNPPDD NAADDVEEE- -GGGYSHLYY VWHHVTLLSS LK----DLLI IIPP-LLEEI FLLLNNPPDD NAADDVEEE- -GGGYSHLYY VWRHVTLLSS LK----DLLI IIPP-LLEEI FLLLNNPPDD NAADDVEEE- -GGGYSHLYY VWRHVTLLSS LK----DLLI IIPP-LLEEI FLLLNNPPDD NAADDVEEE- -GGGYSHLYY VWRHVTLLSS LK----DLLI IIPP-LLEEI FLLLNNPPDD NAADDVEEE- -GGGYKHLHH VWRHVTLLLL MP----DHHI IIPP-LLEEI FLLLDDPPAA ---------- ---------- ---------- ---------- ---------- ---------- RYYPPASSS- -SSSVGIT-- ---------- ---------- ---------- ---------- EMMCCLTTT- -SSSVVISCC LYMRDSLLPP LQ----DAAG GGAANLLCCL SIIIWWKKNN KEEEEVQQQ- -GGGYHSLNN VWEHITIIDD LGEEE-DLLI IIPP-LLEEI FLLLDDPPDD KEEDDVQQQ- -GGGYHSLNN VWEHVTIIDD LGKKK-DLLI IIPP-LLEEI FLLLNNPPDD DQQHHVAAA- -GGGYRHLTT CLRGRTLLDD LGNNN-TLLL LLPP-LLEEI FLLLDDPPAA NQQHHVAAA- -GGGYRHLHH VWGGKTLLDD LGDDD-KLLL LLPP-LLEEI FLLLDDPPAA DQQHHVAAA- -GGGYSHLHH VWGGKLIIDD LGEEE-TLLL LLPP-LLEEI FLLLDDPPSS NQQHHVAAA- -GGGYSHLHH VWGGKLIIDD LGPPP-TLLL LLPP-LLEEI FLLLDDPPSS DQQHHVQQQ- -GGGYRHLHH VWGGKTLLDD LGSSS-TLLL LLPP-LLEEV FLLLDDPPSS NAAHHVGGG- -GGGYNSVHH IWSKLTIIDD LPQQQPLAAL LLPP-LLEEV FLLLEEPPTT NAAHHVPPP- -GGGYNSVHH IWTKLTIIDD LPMMMPRAAL LLPP-LLEEV FLLLEEPPTT EKKCCQPPP- -PPPVKCKRR V--------- ---------- ---------- ---------- HTTDDCDDDR RTTTYCRLNN FWERFTIIDD LGDDD-DLLT TTPP-LLEEI FLLLNNPPRR KVVDDLEEEM MSSSYCRLNN FWTQYTIIDD LGSSS-DIIT TTPP-LLEEI FLLLNNPPKK EFFLLKKKKG GPPPKQHVAA E--------- ---------- ---------- ---------- MQQDDAEEEM MKKKFNTIVV QLTRKVFFNN VPGGGAP--- -----LLEEI FPPPGGSSNN MAADDPEEEM MKKKFNTVVV TLTKKVFFDD VPGGGAP--- -----LLEEI CAAAGGEEAA TTKLMMGGFF NNNSDLSSSI WWWWYYYDDG WWNAAIIEEE EIPPEL---P PEIKPFFKAP TTKLMMGGFF NNNNDLSSSI WWWWYYYDDG WWQAAIIDDD DIEEQF---P PPVKDFFKMP VVREYYGGFF GGGDNLESSI WWWWRRRGGG FFHVVAATTT TIPPEADDDP PPLQGFFGAP VVREYYGGFF GGGDNLESSI WWWWRRRGGG FFHAAAATTT TIPPEAEEEP PPLQGFFGAP SSKDYYGGFF GGGDNLQAAI FFWWQQQDDG FFEAAIITTT TIDDVADDDP PDLKGFFGAP TTKAYYGGFF NNNSDLSSSI WWWWRRRKKD WWAVVIIEEE EIPPEADDDP PPVKGFFKAP TTKAYYGGFF NNNSDLSSSI WWWWRRRNNG WWHLLIIDDD DIPPEADDDP PPIKPFFKAP AARTYYGGFF GGGSDLSSSV WWWWRRRNNG WWGIIIIEEE EIPPEADDDP PPLKDFFGAP SSATQQGGFF GGGSIQRYYK NNEE------ -----TTWWW WSVVKIPPPK KVKWMLLPEG DDATQQGGFF GGGSIQRYYK NNGG------ -----TTWWW WSVVKIPPPK KVKWMLLPEG DDAAQQGGFF GGGSIQRYYK NNGG------ -----TTWWW WSVVKIPPPK KVKWMLLPEG DDAAQQGGFF GGGSIQRFFK NNDD------ -----TTWWW WSAAKIPPPK KVKWMLLPEG DDAAQQGGFF GGGSIQRYYK NNGG------ -----TTWWW WSVVKIPPPK KVKWLLLPEG DDAAQQGGFF GGGSIQRYYK NNGG------ -----TTWWW WSVVKIPPPK KVKWLLLPEG DDAAQQGGFF GGGSIQRYYK NNGG------ -----TTWWW WSVVKIPPPK KVKWLLLPEG DDAAQQGGFF GGGSIQRYYK NNGG------ -----TTWWW WSVVKIPPPK KVKWLLLPEG AAASQQGGFF GGGSIQRYYK NNGG------ -----TTWWW WSVVKIPPPK KVKWMLLPEG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NNINQQDDYY VVVSGRGSSD PPAA------ -----AAVVV VVLLRLYYYV VVAFGVVVSN DDAAQQGGLL GGGSVFRYYK EEDD------ -----KKWWW WAAAKIPPPK KVEWALLPEG DDADQQGGLL GGGSIFRYYK EEDD------ -----KKWWW WAAAKIPPPK KVEWPMMPEG AAKDTTGGFF GGGSMIRFFK TTDD------ -----SSWWW WSHHLIKKKK KVQWILLPEG AAKDTTGGFF GGGTMIRFFK TTDD------ -----SSWWW WNHHIIEEEK KVQWFLLPEG SSKDTTGGYY GGGSMIRFFK NNDD------ -----TTWWW WSYYIIKKKK KVEWILLPEG SSKDTTGGFF GGGSMIRFFK NNDD------ -----TTWWW WSHHVIKKKK KVEWILLPEG SSKDTTGGYY GGGTMVRFFK TTDD------ -----SSWWW WSHHVIKKKK KVRWILLPEG TTSEHHAAFF GGGGIFRHHP VVEESSS--- -----TTHHH HAAALAPPPK KVSWALLPEA TTSEHHAAFF GGGGIFRHHP DDKKPPP--- -----VVQQQ QTAALAPPPK KVEWALLPDA ---------- ---------- ---------- ---------- ---------- ---------- RRENQQGGYY GGGXXXXXX- ---------- ---------- ---------Q QGEGEIIEMG KKKAEEGGFF GGGNVFHKKK KKDDDDD--- -----EEAAA AKKKIIKKKD DTGGVAAEDG ---------- ---------- ---------- ---------- ---------- ---------- NNANYYAAFF TTTTLWLYYE DDAA------ ---------- ------QQQA AVAIGNNPAP AAHNYYCCFF SSSTLWLYYE DDEE------ ---------- ------QQQA AVAIGEEPAP VVTDDSSSLD DDKFLYWWGE EINPKLLTTG KGGHRADD-- ---------- -------GGH VVTDDSSSLD DDRFLYWWGE EINPQLLAAG KGGHREPP-- ---------- -------GGA VVTDDSSSLD DDRFLYWWGE EVDPNLLAAG RGGRRAPP-- ---------- -------GGR VVTDDSSSMD DDRFLYWWGE EVDPKLLAAG HGGRRTPP-- ---------- -------GGK VVTDDSSSLD DDKYLYWWGE EVDPNLLTTG EGGKKTPP-- ---------- -------GGK VVTDDSSSMD DDRFLYWWGD DVDPELLTTG RGGSRATTG- ---------- -------NNG VVTDDSSSVD DDRFLYWWGE EVDPNLLTTG QGGRRAGG-- ---------- -------SSA VVTDDSSSLD DDRFLYWWGE EVDPNHHTTG RGGRKAAA-- ---------- -------SSG IITDDSSSLD DDRFLYWWGD DINPKLLTTG FGGVRGGGQV VVLLL-DQQE TCQPPEPGGK IITDDSSSLD DDRFLYWWGD DINPKLLTTG FGGVKGGGQV VVLLL-DQQE TCQPPEPGGK IITDDSSSLD DDRFLYWWGD DIDPRLLTTG FGGVKGGGQV VVLLL-DQQE KSQPPEPGGK IITDDSSSLD DDHFLYWWGD DVDPRLLTTG FGGVKDGGQV VVLLL-DQQE DSQPPEPGGK IITDDSSSLD DDRFLYWWGD DIDPRLLTTG FGGVKGGGQV VVLLL-DQQE KSQPPEPGGK IITDDSSSLD DDRFLYWWGD DIDPRLL--- ---------- ---------- ---------- IIT------- ---------- ---------- ---------- ---------- ---------- IITDDSSSLD DDRFLYWWGD DIDPRLLTTG FGGVKGGGQV VVLLL-DEEE KSQPPEPGGK IITDDSSSLD DDRFLYWWGD DIDPRLLVVG FGGVKGGGQV VVLLL-DQQE KSQPPEPGGK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FFPPPFFFFD DDLLII---- ---------- ---------- ---------- ---------- IITDDSSSLD DDRFLYWWGD DIDPNLLVVG FGGLRGGGTV VVLLL-DKKD ECQPPDPGGK IITDDSSSLD DDRFLYWWGD DIDTNLLVVG FGGQRGGGTV VVLLL-DKKE ECQPPDPGGK IITDDSSSLD DDRFLYWWGD DIDLNLLTTG WGGQKGSSAA AAIII-EDDG TWQSSDVGGQ IITDDSSSLD DDRFLYWWGD DIDVNLLTTG WGGQKGSSVA AAVVV-DDDG TWQSSDVGGK IITDDSSSLD DDRFLYWWGD DIDPNLLTTG WGGQKGSSKA AAVVV-EDDG SFQFFDVGGK IITDDSSSLD DDRFIYWWGD DIDPNLLTTG WGGQKGSSKA AAVVV-EDDG TFQFFEVGGK IITDDSSSLD DDRYLYWWGD DIDPKLLAAG WGGQKGSSVY YYVVV-EDDD EEQYYSVGGH IITDDSSSMD DDRFLYWWGD DIDPKLLNNS YGGHTESSKV VVLLL-GEEK --PIIEAGGR IITDDSSSMD DDRFLYWWGD DIDPNLLNNS FGGHSETTKV VVLLL-EDDH --EIIPAGGR ---------- ---------- ---------- ---------- ---------- ---------- MMTDDSSSLD DDRYLYWWGD DIDRNLLTTG FGGQRDAARV VVLLL-DPPE KEAPPEPGGR IISDDSSSLD DDRFLYWWGD DIDPNLLTTG FGGCSDLLVI IIVVVEDKKE KERPPPAGGR ---------- ---------- ---------- ---------- ---------- ---------- PPVDDAAAAD DDQTLWFFGK KIDPKQQIIY VDRN------ ---------- ---------- PPVDDSSSND DDSRLWFFGK KIDPHQQVVY TGAN------ ---------- ---------- KKLTGAPPMM MMLLEEIIIR DDDDDGGGRR RVVYYYSYSS STWWDDQQFY PPGGLKGGNA EEATGAPPMM MMIISSVVVR DDDDDGGGRR RVVYYYSYSS SSWWNNQQFY PPGGLRGGNV TTFAGGPPMM MMVVEEIIIR DDDDDGGGRR RVVYYYSYSS STWWDDQQFY PPGGVPAAHA AAFAAGPPMM MMVVEEIIIR DDDDDGGGRR RVVYYYSYSS STWWDDQQFY PPGGVPGGNV TTFGYGPPMM MMVVEEIIIR DDDDDGGGKR RVVYYYSYSS STWWDDQQFY PPDDRGAANV AALNGGPPMM MMVVEEIIIR DDDDDGGGRR RVVYYYSYGG GAVVDDQQFY PPGGIDGGDA EELNGGPPMM MMVVEEIIIR DDDDDGGGRR RVVYYYSYRR RAWWDDQQFY PPGGIKGGDV PPLNGGPPMM MMVVEEVVVR DDDDDGGGRR RVVYYYSYAA ASWWDDQQFY PPGGIRGGEA RRIPGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSYSS SDWWDDQQFY --DDLIRRLQ RRVPGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSYSS SAWWDDQQFY --NNLIRRLQ KKVPGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSYSS SAWWDDQQFY --DDLIRRLQ QQVAGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSYSS SAWWDDQQFY --DDLIRRLQ RRVAGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSYSS SAWWDDQQFY --DDLIRRLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRVAGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSYSS SAWWDDQQFY --DDLIRRLQ RRVPGGPPMM MMIIQQLLLL DDDDDGGGKR RIIYYYSYSS SDWWDDQQFY --DDLIRRLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKVPGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSYSS SKWWDDQQFY --DDMIKKLQ IIIPGGPPMM MMIIQQLLLL DDDDDGGGKR RIIYYYSYSS SIWWDDQQFY --DDLLKKLQ KKLRGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSFSS SAWWDDQQFY --GGLVEELQ KKLRGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSFSS SAWWDDQQFY --KKLVEELQ SSLRGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSFSS SAWWDDQQFY --EELMDDIQ SSLRGGPPMM MMIIQQLLLL DDDDDGGGKR RLLYYYSFSS SAWWVVSSFY --EEIMEEIQ RRLRGGPPMM MMIIQQLLLL DDDDDGGGKR RIIYYYSFSS SRWWDDQQFY GGDDLVKKLQ KKIEGGPPMM MMLLQQLLLL DDDDDGGGKR RLLYYYSYKK KKWWDDQQFY --EEHVKKVQ QQIEGGPPMM MMLLQQLLLL DDDDDGGGKR RLLYYYSYKK KKWWDDQQFY --EENVRRLQ ----GGPPKK KKIIQQLLLV DDDDDGGGKR RLLYYYSYSS STWWDDQQFY --NNVVKKLQ RRLLGGPPMM MMLLQQLLLL DDDDDGGGRR RLLYYYSFSS SPWWDDQQFY --EEMVAAVQ RRLEGGPPMM MMLLQQLLLL DDDDDGGGKR RLLYYYSYSS SPWWDDQQFY --KKMVSSVL ---------- ---------- ---------- ---------- ---------- ---------- --------MM MMVVSSQQQW DDDDDGGGKR RVVYYYSLAA ANWWDD---- ------KKAQ --------MM MMVVSSSSSW DDDDDGGGQR RLLYYYSLAA ANWWDD---- ------KKEQ AAA----PPP GGGGLLEIDK EEEFDFG--- AARRSSSVVS SGGGDAAASD DDSCYPP--- VVV----PPP GGGGLLELEK EEEFDFG--- AARRAAAVVW WGGGDAAASD DDSCYPP--- AAA----PPP GGGGLLTLAD DDDWEFPG-- YYRRAAAIIE EGGGDCCCSD DDSCYPPSSV VVV----GGG GGGGLLELDK DDDFSFPG-- YYRRAAAIIE EGGGDCCCSD DDSCYPPSSV VVV----EEE GGGGLLTLDK DDDWDFPG-- YYRRSSSIIE EGGGDCCCSD DDSCYPPSSV AAA----PPP GGGGIIEFDP KKKFEWPG-- HHRRPPPVVQ QGGGDCCCSD DDSCYPP--- VVV----PPP GGGGMMQFDP NNNFDFG--- QQRRVVVIIQ QGGGDAAASD DDSCFPP--- AAA----PPP GGGGLLSLDP GGGFEVGG-- LLRRPPPIIE EGGGDSSSSD DDSCYPPSS- QQQDDDTVVV GGGGLLKLNP NNNLDFGELG AALLAAALLP PGGGDCCCSD DDII------ QQQDDDTAAA GGGGLLKLNP NNNLDFGELG AALLAAALLP PGGGDCCCSD DDII------ QQQDDDTVVV GGGGLLKLNP NNNLDFGELG AALLAAALLP PGGGDCCCSD DDIL------ QQQDDDTVVV GGGGLLTLNP NNNLDFGELG AALLAAALLP PGGGDCCCSD DDIL------ QQQDDDTVVV GGGGLLKLNP NNNLDFGELG AALLAAALLP PGGGDCCCSD DDII------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQQDDDTVVV GGGGLLKLNP NNNLDFGELG AALLAAALLP PGGGDCCCSD DDII------ QQQDDDTVVV GGGGLLKLNP NNNLDFGELG AALLAAAIIP PGGGDCCCTD DDIL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQQDDDTEEE GGGGLLKLNP NNNLDFGEGG VVLLAAALLP PGGGDCCCSD DDIV------ QQQDDDTKKK GGGGLLKLNP NNNLDFGEDG VVLLAAAIIP PGGGDCCCTD DDII------ QQQDDDTEEE GGGGLLKINP NNNFDFGEDG AALLAAAMMP PGGGDCCCTD DDII------ QQQDDDTEEE GGGGLLKINP NNNFDFGEDG SSLLAAAMMP PGGGDCCCTD DDII------ QQQDDDTEEE GGGGLLSINP NNNFDFGEEG AALLAAAMMP PGGGDCCCTD DDII------ QQQDDDTEEE GGGGLLTINP DDDFDFGEDG SSLLAAAMMP PGGGDCCCTD DDII------ QQQDDDTEEE GGGGLLSINP NNNFDFGEEG SSLLAAAMMP PGGGDCCCTD DDII------ QQQNDDPEEE GGKKMMEINR DDDLDFGIGG YYLLAAAMMP PGGGDCCCTD DDII------ QQQDDDPIII GGHHMMVINK NNNLDFGVGG YYLLAAAMMP PGGGDCCCTD DDII------ QQQDDDTEEE GGGGLLTVNK NNNLDFGENG CCLLAAAIIP PGGGDSSSTD DDIA------ QQQDDDVEEE GGGGMMKLNE NNNLDFGEYG GGLLPPPMM- ---------- ---------- LLLDDDTVVV GGGGIISLNE DDDLDFAEYG SSLLPPPMMP PGGGDCCCTD DDILANNDDA ---------- ---------- ---------- ---------- ---------- ---------- QQQLAAYNNN DDGGKKELVE DDDADFYLLG --RRAAAMMG GSSSALLLYS SS-------- QQQLLLYYYY DDGGKKELKE QQQADFYELG --RRPPPMMG GRRRALLLYG GGPGDGGNNR ------- ------- V------ V------ V------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- A------ ------- ------- RQAAREE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNNKKAKQQP PSSEEAAPPP RTAVVTGGLT ARLLLDGAMM QSQLLLLLGS SSSPVVRRIK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AQEWFSSIVA ASSSPSSGGT RRSSVPPPGL ISAVVAVVPS QAAAVQHHHW WLLLPPGGHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----EERREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMMG GLLLKKEEPP ---------- ---------- ---------- ---------- ------KKKN NSSSGGCCGG ---------- ---------- ---------- ---------- ---------- ---------- -AGATLPLNT TPTTPPPAAS PPPPHPPPRV TLVRRPIINV PPPRLPPPPH HAAAHHSSVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMMRRRRFF ---------- ---------- ---------- ---------- ---------- -MMMRRFFVV ---------- ---------- ---------M AAIIVFFFPP TFPPPPPKKM AMAAPDLAAY ---------- ---------- ---------- --MMALLLPP TFPPPPPRRD AMAAPDIAAY ---------- ---------- ---------- ----MMMMPP TFAAPPPEEL AMAAPEFAAY ---------- ---------- ---------- ----MMMMPP TFAAPPPKKL AMAAPNFAAY ---------- ---------- ---------- ----MLLLPP TFPPAAAKKL AMGGPKLAAF ---------- ---------- ---------- --MMAWWWPP SFPPPPPRRL AAAAPTIAAY ---------- ---------- ---------- --MMVWWWPP TFPPPPPRRM AVAAPKLAAY ---------- ---------- ---------- --MMAWWWPP TFPPPPPKKM AMAAPRLGGY ---------- ---------- -----MMMAT KKCCT---PP GYTTLLLEEA MKGGPEIVVY ---------- ---------- ---------- ---------- ---------- -MGGPEIVVY AAAAVVLIIA PPPRGLLLLP PGGAAHHHST QQCCG---PP GYSSLLLEEA MKGGPEIVVY ---------- ---------- ---------- ---------- ---------- MKGGPEIIIY ---------- ---------- -----MMMAT KKCCG---PP GYTTLLLEEA MKGGPEIVVY AFFFTTLQQS VVVQPMMMRP PIISSTTTAT KKCCG---PP GYTTLLLEEA MKGGPEIVVY ---------- ---------- -----MMMAT KKCCG---PP GYTTLLLEEA MKGG------ ---------- ---------- -----MMMAT KKCCG---PP GYTTLLLEEA MKGGPEIVVY HTTTAAQPPW FFFSGQQQLW WQQDDTTTAT KKCCG---PP GYTTQQQEEA MKGGPEIVVY DQQQTTNTTE LLLTYCCCTL LVVTTSSSPT KKCCG---PP GYTTLLLEEA MKGGPEIVVY ---------- ---------- -----MMMAT KKCCG---PP GYTTLLLEEA MKGGPEIVVY QHHHIIMEEG AAAAVEEETA AAAAANNNGK TTCCCTTTPP GYTTLLLEEA MEGGPKLVVY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MA KKCCG---PP GYSSLLLDDA MKGGPEIVVY ------MAAT VVVDHGGGVV VNNKKKKKS- VVNNGCCCPP GYSSIIIEES MSGGPSLIIY ------MGGT VVVQHAAAVV VSSKKVVVNN QQQQGCCCPP GYSSLLLEEA MSGGPTLIIY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --RRMQQQPP GYTTLLLAAA MSGGPKLIIY ---------- --------MA AAAAANNNGA AACCCGGGPP GYTTLLLEEA MEGGPKLLLY ---------- ---------M MSSNNCCCGL KKCCH---PP GYSSAAADDA IKGGPEVLLF ---------- ---------M MPP--CCCPL KKCCH---PP GYSSAAADDA IKGGPEVLLF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M SSEESCCCPP GYTTLLLDDA VRGGPKLLLY ---------- ---------- ---------- ---------- ---------- MRGGPKLLLY ---------- ---------- ---------- --------PP GLTT---DDI LILLDFLYYF ---------- ----ALLLAA AGGAALLLAM GGLLPRRRDD ETQQPPPYYM PKTTGEFVVY GPPPSSMHHF AAARALLLVS SGGAALLLAL AAAAPGGGDD ETAAPPPYYM KKTTGDYVVY ALYYGTTIII AIIAVDNSSS EYYYSSIVHK EELLNEFFGW NSSAL-G--- KKKIIERFLP ALYYGTTVVV PLLAVDDSSS PYYYGGVIYK DDLLGEFFGW NSSAY-A--- KKKLLERYLP LLSSDFF--- PLLAIDKSSS SYYYGGIVHT TTMMGEFFGW NSSSL-TGGG HHHLLERFLP LLSSDFF--- PLLAIDKSSS PYYYGGIVHT TTMMGEFFGW NSSAL-AGGG HHHIIERYLP LLSSDAA--- PLLAVDDSSS EFFFGGIVHQ IIMMGEFFGW NSSAL-TGGG HHHLLERYLP AFDDERR--- PIIAVDDSSS PYYYAAIVGQ AAMMGEFFGW NSSCL-APPP HHHMMERYLP VLNNMAAGGG PMMCVDDSSS SFFFGGVVGV DDMMGEFFGW NSSML-APPP HHHVVERYLP ALDDGRR--- PLLGLDDSSS GYYYAAIVGR EEMMAEFFGW NAAAL-APPP HHHVVERYLP PIYYNTTTTT PLLAVDDSSS PYYYSSVIHR PPMMKESSGW NSSC--FGGG DDDKKSRKLP PIYYNTTIII PLLAVDDSSS PYYYSSVIHR PPMMKESSGW NSSC--FGGG DDDKKSRKLP PIYYNTTIII PLLAVDDSSS PYYYCCVIHR PPMMRESSGW NSSC--FGGG DDDKKSRKLP PIYYNTTIII PLLAVDDSSS PYYYCCVIHR PPMMKESSGW NSSC--YGGG DDDKKARKLP PIYYNTTTTT PLLAVDDSSS PYYYCCVIHR PPMMKESSGW NSSC--FGGG DDDKKSRKLP PIYYNTTTTT PLLAVDDSSS PYYYCCVIE- ---------- ---------- ---------- -------TTT PLLAVDDSSS PYYYCCVIHR PPMMKESSGW NSSC--FGGG DDDKKSRKLP PIYYNTTTTT PLLAVDDSSS PYYYCCVIHR PPMMKESSGW NSSC--FGGG DDDKKSRKLP PIYYNTTTTT PLLAVDDSSS PYYYSSVIHR PPMMKESSGW NSSC--FGGG DDDKKSRKLP PIYYNTTTTT PLLAVDDSSS PYYYCCVIHR PPMMKESSGW NSSC--FGGG DDDKKSRKLP PIYYNTTTTT PLLAVDDSSS PYYYCCVIHR PPMMKESSGW NSSC--FGGG DDDKKSRKLP TVYYGTTIII LLLAVDDSSS PYYYSSVIHR PPVVGKSSGW NSSC--HGGG DDDAAKRFLP ---------- ---------- ---------- --MMNESSGW NSSC--YGGG DDDKKVRKLP PIYYSTTIII PLLAVDDSSS PYYYSSVIHR PPMMNESSGW NSSC--YGGG DDDKKVRKLP TVYYGTTIII PLLAVDDSSS PYYYSSVIHR PPVVGETTGW NSSC--HGGG DDDAAERFLP TVYYGTTIII PLLAVDDSSS PYYYSSVIHR PPVVGETTGW NSSC--HGGG DDDAAQRFLP ---------- ---------- ---------- --MMGESSGW NSSC--HGGG DDDAADRYLP TVYYGTTIII PLLAVDDSSS PYYYSSVIHR PPMMGESSGW NSSC--HGGG DDDVVDRYLP TVYYGTTIII PLLGVDDSSS PYYYSSVIHR PPVVGESSGW NSSC--HGGG DDDAASRFLP TP---NNAAA PIIFVDNSSS DFFFCCVISR DDVVGETTGW NSSC--HDDD KKKEEKRHLP TP---HHRRR PIIFVNNSSS EFFFCCIISR DDVVGETTGW NSSC--HDDD KKKEEKRHLP ---------- ---------- ---------- ---------- ---------- --------MR VVQQNLLEEE GLLAVDDSSS PYYYCCVIHR YYTTHESSGW NSSCHVGGGG KKKPPTRRLP VVQQNLLEEE GLLSVDDSSS PYYYCCIVHR FFTTGESSGW NSSCYVSSSS KKKPPKRRLP NLHHDIIQQQ IRRKPRVVVV FGGGGGVLKD PPVVEKSSQP TLLK---GGG KKKQQGGQML WLGGEGGGGG QLLVIDRSSS ARRRGGVINS SSVVREGGGF S--------- -----DRFFG WLGGEGGGGG QLLVVDNSSS PYYYGGVVNT SSVVRESSDF T--------- -----DRYLG PGGLLSIIYI IITPPRREEI IIIIIKKEEP KKKKSSLHTT VCGPIYIIIA L-EEG-EGGP PAALLSIIYI VVTPKRRRRV VAAAAKKEEP VVGGTTYHTT VCGPIYIIIA L-DDGREGGP PGGLLSIIYV IITPPTTQQI IHHHHKKEEP LLAATTPHTT VCGPIYVVVT LKDDGTDGGA PGGLLSIIYI IITPPTTKKI IHHHHKKEEP FFKKTTPHTT ICGPIYVVVT LKDDGTNGGP PGGIISIIYI VVV-PLLKKI IHHHHKKEEP FFAATTPHTT ICGPIYVVVT LEDDGTDGGP PGGLLSIIYI LLTPPLLKKL LAAAAKKEEP AAEETTPHTT VCGPIYVVVA L-EEG-KGGP PDDIISIITI LLTPPTTQQV VVVVVKKDDP AAEETTPHTT VCGPIYIIIA L-EEG-EGGP PGGIISIIHI VVTPPRREEI IVVVVKKEEP HHRRTTPHTT ICGPVYVVVA L-EEG-DGGP PGGLLSIIYV VVVSPRRAAL LHHHHKKEEA QQAACCTHTT SCLAEVMMMN T-LLQGNGGK PSSIISIIYV VVVSPRRAAL LHHHHKKEEP HHAACCLHTT SCLAEVMMMS S-PPQGNGGK PCCLLSIIYV VVVSPRRAAL LHHHHKKEEA HHAACCVHTT SCLAEVMMMS T-SSKGNGGK PAALLSIIYV VVVTPRRAAL LHHHHKKEEP HHTTCCFHTT SCLPEVMMMS T-PPEGNGGK PSSLLSIIYV VVVSPRRAAL LHHHHKKEEP HHAACCLHTT SCLAEVMMMS S-VVKGNGGK ---------- ---------- ---------P HHAACCLHTT SCLAEVMMMS S-VVKGNGGK PSSLLSIIYV VVVSPRRAAL LHHHHKKEEP HHAACCLHTT SCLAEVMMMS S-VVKGNGGK PSSLLSIIYV VVVSPRRAAL LHHHHKKEEP HHAACCLHTT SCLAEVMMMS S-VVKGNGGK PSSFFSIIYV VVVTPRRAAL LHHHHKKEEA HHEECCPHTT SCLPEVMMMS T-PPKGNGGK PSSLL----- ---------- ---------- ---------- ---------- ---------- PSSLLSIIYV VVVSPRRAAL LHHHHKKEEP HHAACCLHTT SCLAEVMMMS S-VVKGNGGK PSSLLSVVYV VVTTPRRTTL LHHHHKKEES AAEEIIPHTT SCLADIMMMS C-KKEGNAAA PCCLLSIIYV VVVTPRRAAI IHHHHKKEEP FFWWCCLHTT SCLGEIMMMS S-PPYGNGGK PCCLLSIIYV VVVSPRRAAI IHHHHKKEEP FFWWCCPHTT SCLGEIMMMS S-PPCGNGGK PSSLLSIIYV IITTPRRSSL LHHHHKKDDP IIQQTTPHTT SCLAELMMMS C-KKDGNAAE PGGIISVVYV IITTPRRAAL LHHHHKKEEP SSTTTTPHTT SCLAEIMMMS C-KKDGNAAE PSSLLSIIYA IITEPRRAAL LYYYYKKDDP AAEETTPHTT ACLAEILLLS C-EEEGNAAK PSSLLSIIYA IITEPRRAAL LYYYYKKDDP AADDTTPHTT ACRTEILLLS C-EEEGNAAK PSSLLSVVYV VVTKPRRAAL LHHHHKKEEA AAEETTPHTT SCLAEIMMMS C-KKEGNAAA PCCLLSIIYI IIVN-RRKKL LEEEEHHEEP HHSSNNPHTT SCLANIMMMS T-AANGTPPS PCCLLSIIYV IIVN-RREEL LQQQQHHEEP HHAANNPHTT SCLANIMMMS T-AADGSPPS RKKLLSEEGK VVVG------ ---------- ---------- ---------- ---------- PCCLLSIIFV IITTPRRAAL LAAAAKKEEG LLKKAAPHTT TCLPNIMMMS I-AAEGNAAK PSSLLSIIYI LLVTPRRKKI IVVVVKKDDG LLKKHHPHTT TCLANIMMMS V-AAEGYAAK LSSLLGLLYV TTSYAWWDDF FYYYYPP--- IIKKLLSHTT AYQPALKKKD G-SSLSVPPV GGGLLTIIFI FFVSPSSNNL LHHHHKKDDT KKDDGGPHTT FALPMMIIIG L-DDDHGGGR GGGLLTIIFV FFVSPAARRL LSSSSKKTTD EEKKGGPHTT LALPMLIIIG L-KKDHGGGR GGILMLYYFF FLGGKWWWED DQY------- ----LLAAYY DDFWW-PNEV VVVSSSSAAV GGIFLLDDFF FIGGRWWWEY YQY------- ----FFAAYY DDFWW-PSGV VVITTSSTTV PGIFIMEEFF FLGGRWWWED DQD------- ----KKHHYY DDFWW-PRDY YYVSSSSAAL PGVFIMEEFF FLGGRWWWED DQT------- ----LLHHYY DDFWW-PRDY YYVTTSSAAL PGIFILEEFF FLGGRYYYED DQT------- ----KKHHYY DDFWW-PRDY YYVSSSSGGL GGIAMLQQFF FLGGRWWWEE EQY------- ----FFAAYY DDGWW-GYDT TTVTTSSGGT GGIFILDDLL LLGGRWWWED DQY------- ----LLHHYY DDFWW-GYDT TTLTTSSGGT GGVFVMEEFF FLGGRWWWEE EQQ------- ----LLAAYY DDFWW-GYDT TTVTTSSGGT GSFVLLEEFF FKGGTWWWEP PSP------- ----MMGGYY DDFWY-RHNV VVVSSTTAAA GGFVLLEEFF FKGGTWWWEP PAP------- ----MMGGYY DDFWY-RHNI IIVSSTTAAA GGFVLLEEFF FKGGTWWWEP PAP------- ----MMGGYY DDFWY-RHNV VVISSTTAAA GGFVLLKKFF FKGGTWWWEP PAP------- ----LLGGYY DDFWY-RHNV VVISSTTAAA GGFVLLEEFF FKGGTWWWEP PAP------- ----SSGGYY DDFWY-RHNV VVISSTTAAA GGFVLLEEFF FKGGTWWWEP PAP------- ----LLGGYY DDFWY-RHNV VVISSTTAAA GGFVLLEEFF FKGGTWWWEP PAP------- ----LLGGYY DDFWY-RHNV VVISSTTAAA GGFVLLEEFF FKGGTWWWEP PAP------- ----LLGGYY DDFWY-RHNV VVISSTTAAA GGFVLLEEFF FKGGTWWWEP PAP------- ----MMGGYY DDFWY-RHNV VVISSTTAAA ---------- ---------- ---------- ---------- ---------- ---------- DGSLVL--LL LSGG------ ---------- ---------- ---------- -----AAAAH GNGFLLSSFF FKGGRGGGSR RIS------- ----KKEERR TTHLYYAWGL LLWSSWWCCC GGFVLLEEFF FKGGNWWWEE EAP------- ----FFGGYY DDFWY-RHNV VVISSTTGGA GGFVLLEEFF FKGGNWWWEE EAQ------- ----FFGGYY DDFWY-RHNV VVISSTTGGA GNGFLLSSFF FKGGRWWWEP PPL------- ----FFGGYY DDFWY-RHNT TTISSTTGGA GNGFLLSSFF FKGGRWWWEP PPL------- ----FFGGYY DDFWY-RHNT TTISSTTGGA GNGFLLSSFF FKNNRWWWEP PPL------- ----FFGGYY DDFWY-RHKT TTISSTTGGA GNGLLLSSFF FKNNRWWWEP PPL------- ----YYGGYY HHFWY-RHKT TTISSTTGGA GNGFLLSSFF FKGGRWWWEP PPL------- ----FFGGYY DDYWY-RHKT TTISSSSGGA GNFLLLKKFF FKGGTWWWPD DVP------- ----FFNNYY DDFWY-RRNV VVISSTTGGS GNFLLLKKFF FKGGTWWWPD DVP------- ----FFNNYY DDFWY-RRNI IIISSTTGGS ---------- ---------- ---------- ---------- ---------- ---SSIIGGG G-DFVEKKFF FVGGTWWWSG GAL------- ----CCGGYY DDYWY-HFNV VVVAASSGGA G-DFILSSFF FIGGTWWWTG GAL------- ----CCGGYY DDFWY-YFDV VVVSSSSGGA LNGIQTHHNN NSAAKGGGES SEI------- ----LLQQLL SSNHN--REK KKESSDDDDE TALVEYDDEE EATTYWWWMT TMQGAAAGAA DDGGYYGGYY DDIRA-RKNV VVLTTSSTTG TALVEYAAEE EATTHWWWIT TLRGKKKGKK DDGGYYDDYY DDVRA-RKNL LLVTTSSTTG NNN-IIEDGG -KKLEHHLD- --RGNIIFFW WDDLRRRRRI ILGEEENNRA AL-----LRL RRR-FFEEGG -SSLECCLEG GGAGNLLVVW WDDLAAARHL LIGQQEHHRV VL-----VRL PPP-FFENGG -VVPEDDLAN NNKGHLLFFW WDDLRRRRNV VIGAAQHHQA AL-----VRA PPP-FFENGG -VVPEDDLSN NNKGHLLFFW WDDLRRRRNV VIGAANHHQA AL-----VRA PPP-FFENGG -VVPEDDLSN NNKGHIIFFW WKKLRRRRNV VIGAANHHQA AL-----IRA DDD-VVEDGG -VVPDIILGA AARGRLLFFW WDDLTTTRHL LIGDDEHHQV VF-----LRA RRR-VVESGG -LLGDEELAG GGKGHLLVVW WDDLYYYRHL LLGAAEYYQA AL-----LRA NNN-IIEGGG -DDPQIILNK KKGGRLLIIW WDDLRRRRHL LLGEEEHHQV VL-----LRA NNN-FFKDGG FPPAHVVE-G GGLGSIIVVW WDDWQQQHII ILT---DDGI IP-----IRL NNN-FFKDGG FPPAHVVE-G GGLGSIIVVW WDDWQQQHII ILK---DDGI IP-----IRL NNN-FFRDGG FPPADVVE-G GGLGSLLVVW WDDWQQQHII ILQ---DDGI IP-----IRL NNN-LLRDGG FPPADVVK-G GGLGSLLVVW WDDWQQQRIV VLQ---DDGI IP-----IRL NNN-LLRDGG FPPADVVE-G GGLGSLLVVW WDDWQQQHIV VLK---DDGI IP-----IRL NNN-LLRDGG FPPADVVE-G GGLGSLLVVW WDDWQQQHIV VLK---DDGI IP-----IRL NNN-LLRDGG FPPADVVE-G GGLGSLLVVW WDDWQQQHIV VLK---DDGI IP-----IRL NNN-LLRDGG FPPADVVE-G GGLGSLLVVW WDDWQQQHIV VLK---DDGI IP-----IRL NNN-VVQNGG FPPADVVE-G GGLGKLLVVW WDDWQQQHIV VLP---DDGI IP-----IRL ---------- ---------- ---------- ---------- ---------- ---------- NNN-RRLTGG SDDYPAAS-S SSRAGTT--- ---------- ---------- ---------- LLL-YYTTGG ALLMCLLT-S SSGHVSSLLD DNNYIIIRID DLQ---DDQG GANNPIILRI KKK-FFALGG FMMEEVVQ-G GGMGHLLVVW WDDWTTTHRI IIGEE-DDGI IP-----IRL KKK-FFALGG FMMEDVVQ-G GGHGHLLVVW WDDWTTTHLV VIGKK-DDGI IP-----IRL TTT-FFTKGG FLLQHVVA-G GGLGRLLCCI IQQLAAAGLR RLGNN-TTGL LP-----IRL KKK-FFLQGG FLLQHVVA-G GGLGRLLVVY YSSWPPPGIK KLGDD-KKGL LP-----IRL KKK-FFSKGG FLLQHVVA-G GGLGSLLVVY YSSWPPPGMK KIGEE-TTGL LP-----IRL KKK-FFSKGG FLLQHVVA-G GGLGSLLVVY YSSWPPPGIK KIGPP-TTGL LP-----IRL AAA-FFRTGG FLLQHVVQ-G GGLGRLLVVY YDDWPPPGLK KLGSS-TTGL LP-----VRL NNN-IIKKGG FPPAHVVG-G GGLGNVVIIF FEEWDDDKYL LIPQQPLLGL LP-----VRL NNN-IIKKGG FPPAHVVP-G GGLGNVVIIF FEEWDDDKHL LIPMMPRRGL LP-----VRL VVV-VVCRDD ELLKCQQP-P PPLIKKKVVY Y--------- ---------- ---------- KKK-FFRRGG YPPTDCCDRT TTQGCLLFFY YRRWQQQRLF FIGDD-DDGT TP-----IRL NNN-WWRRGG WNNVDLLEMS SSQGCLLFFY YKKWSSSQLY YIGSS-DDGT TP-----IRL III-AAFESS SSSFLKKKGP PPLPQVVEEV VLL------- ---------- ---------- SSSYMMDFGG QLLQDAAEMK KKRGNIIQQW WDDLHHHRPK KFPGGAPP-- -------IRP NNNYMMDFGG KLLADPPEMK KKHGNVVTTW WDDLHHHKPK KFPGGAPP-- -------IRA DDPTINNMVV KKKKDLLSSS SSSSIWLWWW EEDGKNEKKI IIEEIIPPPA AAEELLEELL DDPTVNNVVV KKKKDLLSSS SSSSIWLWWW EEDGKQERRI IIDDIIEEEA AAQQFFEELL DDPVVGGVVV TTTTNLLGGG SSSSIWTWWW EEGGKHKKKA AATTIIPPPA AAEEAATTLL DDPVVGGVVV TTTTNLLAAA SSSSIWTWWW EEGGKHEKKA AATTIIPPPP PPEEAAPPLL DDPSCGGVVV TTTTNLLGGG AAAAIFTWWW DDDGTEKKKI IITTIIDDDP PPVVAADDLL DDPTVNNCVV KKKKDLLSSS SSSSIWTWWW DDKDKARKKI IIEEIIPPPA AAEEAADDLL DDPTMNNCVV KKKKDLLAAA SSSSIWLWWW DDNGSHKKKI IIDDIIPPPA AAEEAASSLL DDPAVGGVVV EEEEDLLAAA SSSSVWLWWW QQNGSGRKKI IIEEIIPPPA AAEEAAEELL DDPSVGGCAA NNNNIQQFFF YYYYKNEEEE ---------T TTWWSSVVVE EEKKIIQQKK DDPDVGGCAA NNNNIQQFFF YYYYKNEGGG ---------T TTWWSSVVVE EEKKIIQQKK NNPDVGGCAA TTTTIQQFFF YYYYKNQGGG ---------T TTWWSSVVVE EEKKIIQQKK NNPDVGGCAA TTTTIQQFFF FFFFKNEDDD ---------T TTWWSSAAAQ QQKKIIQQKK NNPDVGGCAA TTTTIQQFFF YYYYKNEGGG ---------T TTWWSSVVVE EEKKIIQQKK NNPDVGGCAA TTTTIQQFFF YYYYKNEGGG ---------T TTWWSSVVVE EEKKIIQQKK NNPDVGGCAA TTTTIQQFFF YYYYKNEGGG ---------T TTWWSSVVVE EEKKIIQQKK NNPDVGGCAA TTTTIQQFFF YYYYKNEGGG ---------T TTWWSSVVVE EEKKIIQQKK DDPAVGGCAA TTTTIQQFFF YYYYKNEGGG ---------T TTWWSSVVVE EEKKIIEEKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WWKNDVVVEE SSSSGRRGGG SSSSDPDAAA ---------A AAVVVVLLLK KKRRLLDDAA DDPDVGGCAA TTTTVFFFFF YYYYKEKDDD ---------K KKWWAAAAAE EEKKIIKKKK NNPDVGGCAA SSSSIFFFFF YYYYKEKDDD ---------K KKWWAAAAAE EEKKIIQQKK DDPAVGGSAA NNNNMIIFFF FFFFKTQDDD ---------S SSWWSSHHHE EELLIIPPLL DDPAVGGSAA NNNNMIIFFF FFFFKTQDDD ---------S SSWWNNHHHE EEIIIISSLL DDPSVGGSAA NNNNMIIFFF FFFFKNSDDD ---------T TTWWSSYYYE EEIIIISSLL DDPSVGGSAA NNNNMIIFFF FFFFKNSDDD ---------T TTWWSSHHHE EEVVIISSLL DDPSVGGCAA NNNNMVVFFF FFFFKTADDD ---------S SSWWSSHHHE EEVVIISSLL EEPTVGGCAA GGGGIFFIII HHHHPVEEEE -------TTT TTHHAAAAAT TTLLAAFFKK EEPTVGGCAA AAAAIFFIII HHHHPDEKKK -------KKV VVQQTTAAAS SSLLAATTKK ---------- ---------- ---------- ---------- ---------- ---------- NNPRVGGCAA XXXXXXXXXX XXXX------ ---------- ---------- ---------- NNPKVGGCAA KKKKVFFFFF KKKKKKSDDD -------EEE EEAAKKKKKV VVIIIIPPVV ---------- ---------- ---------- ---------- ---------- ---------- GGSNSTTTAA QQQQLWWIII YYYYEDDAAA ---------- ---------- ------EEKK GGEATSSTAA QQQQLWWIII YYYYEDGEEE ---------- ---------- ------EEKK PPLLLKPPFA AVVIIIDDLK KLLLLSLLWG GGGGEVRRDS NNPFKKLLTK VKLLGGGAAD PPLLLKDDFM MVVIIIDDLR RLVVVSLLWG GGGGELRRDT NNPHQQLLAR VKIIGGGEEP PPLLLQGGFA AVVIIIDDLR RLVVVSCCWG GGGGEMRRDS DDPHNNLLAS VRIIGGGAAP PPLLLQGGFA AVVIIIDDMR RLVVVSCCWG GGGGEMRRDS DDPRKKLLAS VHIIGGGTTP PPLLLKGGFA ACVIIIDDLK KLVVVACCWG GGGGEMHHDS DDPMNNLLTK VEIIGGGTTP PPLLLKGGFA AVVIIIDDMR RLVVVSCCWG GGGGDLLLDS DDPFEELLTK VRIIGGGAAT PPLLLKPPFA AVVIIINNVR RLVVVSCCWG GGGGELHHDS DDPFNNLLTK VQIIGGGAAG PPLLLKDDFA AVVIIINNLR RLVVVSCCWG GGGGELRRDS DDPFNNHHTS VRLLGGGAAA KKGGGWMMLE EMIIIILLLR RLFFFSNNWL LGGGDIRRDS NNPQKKLLTQ IFLLGGGGGG KKGGGWMMLE EMIIIILLLR RLFFFSNNWL LGGGDIRRDS NNPKKKLLTQ IFLLGGGGGG KKGGGWMMLE EMIIIILLLR RLFFFSNNWL LGGGDLRRDS DDPQRRLLTQ LFLLGGGGGG KKGGGWMMLE EMIIIILLLH HLFFFSNNWL LGGGDIRRDS DDPQRRLLTQ LFLLGGGDDG KKGGGWLLLE EMIIIILLLR RLFFFSNNWL LGGGDLRRDS DDPQRRLLTQ LFLLGGGGGG KKGGGWLLLE EMIIIILLLR RLFFFSNNWL LGGGDLRRDS DDPQRRLL-- ---------- KKGGGWLLLE EMI------- ---------- ---------- ---------- ---------- KKGGGWLLLE EMIIIILLLR RLFFFSNNWL LGGGDLRRDS DDPQRRLLTQ LFLLGGGGGG KKGGGWMMLE EMIIIILLLR RLFFFNNNWL LGGGDMRRDS DDPKRRLLVQ IFLLGGGGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVKKKFGGVS SLFAAAWWFL LIFFFLSS-- ---------- ---------- ---------- KKGGGWAALE EMIIIILLLR RLFFFSNNWL LGGGDIRRDT DDPRNNLLVQ IFLLGGGGGG KKGGGWPPME EMIIIILLLR RLFFFSNNWL LGGGDIRRDT DDTRNNLLVQ IFLLGGGGGG KKNNNWIILE EMIFFFLLLR RLFFFVNNWL LGGGDIRRNE DDLKNNLLTQ LWVVGGGGGS KKNNNWFFLE EMIFFFLLLR RLFFFVNNWL LGGGDIRRNE DDVKNNLLTQ VWAAGGGGGS KKNNNWIILE EMIFFFLLLR RLFFFVNNWL LGGGDIRRNE DDPKNNLLTQ IWVVGGGGGS KKNNNWIILE EMIFFFLLLR RIFFFVNNWL LGGGDIRRNE DDPKNNLLTQ IWVVGGGGGS KKNNNWIILE EMIFFFVVLR RLLLLVNNWL LGGGDIRRNE DDPAKKLLAQ VWAAGGGGGS KKGGGWAALE EMIIIILLMR RLVVVSCCWL LGGGDIRRDS DDPLKKLLNQ VYIIGGGEES KKNNNWAALD DMIIIILLMR RLVVVSCCWL LGGGDIRRDS DDPKNNLLNQ VFIIGGGEET ---------- ---------- ---------- ---------- ---------- ---------- QQNNNGEEIM MMMIIILLLR RLFFFSNNWR RGGGDVRRDS DDRANNLLTQ VFLLGGGDDA DDSSSGVVAD DMIIIIIILR RLVVVNCCWR RGGGDVRRDT DDPENNLLTQ LFLLGGGDDL ---------- ---------- ---------- ---------- ---------- ---------- AADDDIGGNA ADPIIISSAQ QLIIINSSFM MGGGKTRRDS DDPHKKQQIE KVIIDRR--- AADDDIGGEA AKPIIISSNS SLVVVNTTFM MGGGKTRRDS DDPHHHQQVE KTIIGAA--- DHPP------ ---------- -------AGG KLTTAPQQML EEIISRGVYY YVNLYSSSSW PHPP------ ---------- -------SGG EATTAPQQMI SSVVSRGVYY YINLYSSSSW PHPP------ ---------- -------NGG TFAAGPQQMV EEIISRGVYY YWNLYSSSSW PHPP------ ---------- -------NGG AFAAGPQQMV EEIISRGVYY YWNLYSSSSW PHPP------ ---------- -------NGG TFGGGPQQMV EEIISRGVYY YWNLYSSSSW THPPGG---- ---------- -------KNN ALNNGPQQMV EEIISRGVYY YFNLYGGGGV GHPP------ ---------- -------TSS ELNNGPQQMV EEIISRGVYY YFNLYRRRRW AHPP------ ---------- -------ASS PLNNGPQQMV EEVVSRGVYY YFNLYAAAAW GSVVQQLLEE --DEELLTPE EEEEEPVKGG RIPPGPQQMI QQLLSLGLYY YATLYSSSSW GSVVQQLLEE --DEELLTPE EEEEEPVKGG RVPPGPQQMI QQLLSLGLYY YVTLYSSSSW GPVVQQLLEE --DEELLKPE EEEEEPVKGG KVPPGPQQMI QQLLSLGLYY YVTLYSSSSW GPVVQQLLDD --DEELLDPE EEEEEPVKGG QVAAGPQQMI QQLLSLGLYY YVTLYSSSSW GPVVQQLLEE --DEELLKPE EEEEEPVKGG RVAAGPQQMI QQLLSLGLYY YITLYSSSSW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GPVVQQLLEE --DEELLKPE EEEEEPVKGG RVAAGPQQMI QQLLSLGLYY YITLYSSSSW GPVVQQLLEE --DEELLKPE EEEEEPVKGG RVPPGPQQMI QQLLSLGIYY YVTLYSSSSW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GPVVTTLLEE --DDDLLEPD DDDDDPIKGG KVPPGPQQMI QQLLSLGLYY YVNLYSSSSW GPVVTTLLEE --DEELLEPD DDDDDPTKGG IIPPGPQQMI QQLLSLGIYY YVSLYSSSSW SPVVAAIIGG --EGGKKTSD DDDDDVEQGG KLRRGPQQMI QQLLTLGLYY YVNLFSSSSW SPVVVVVVKK --DGGEETSD DDDDDVEQGG KLRRGPQQMI QQLLSLGLYY YVNLFSSSSW SPVVKKVVGG --EGGNNSFD DDDDDVQKGG SLRRGPQQMI QQLLSLGLYY YANLFSSSSW SPVVKKVVGG --EGGNNTFE EEEEEVQKGG SLRRGPQQMI QQLLSLGLYY YANLFSSSSW SEVVVVVVTT --EDDKKEYS SSSSSVQKGG RLRRGPQQMI QQLLSLGIYY YVNLFSSSSW SNVVKKLLEE --GKK---IE EEEEEAYKGG KIEEGPQQML QQLLSLGLYY YVTLYKKKKW TTVVKKLLEE --EHHDD-IP PPPPPAYKGG QIEEGPQQML QQLLSLGLYY YVTLYKKKKW ---------- ---------- ---------- ----GPAAKI QQLLSVGLYY YVNFYSSSSW APRRRRLLNN --DEELLKPE EEEEEPFKGG RLLLGPQQML QQLLSLGLYY YVSLFSSSSW LPNNVVVVKK EEDEELLKPP PPPPPAYKGG RLEEGPQQML QQLLSLGLYY YVSLYSSSSW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MV SSQQSWGVYY YFSLLAAAAW ---------- ---------- ---------- --------MV SSSSSWGLYY YYSLLAAAAW NNQFPPKKGM MVKLNAN--- -GLIFFFDGE E----ARSSQ QVVLLLGAAS SSSSSYYCCY NNQFPPRRGM MAKVNVN--- -GLLFFFDGR R----ARAAQ QVVLLLGAAS SSSSSFFCCY DDQFPPPPAQ QVLAHAG--- -GLLYYWEPD DGGG-YRAAQ QIILLLGCCS SSSSSFFCCY DDQFPPPPGE EVMANVG--- -GLLYYFSPD DGGG-YRAAQ QIILLLGCCS SSSSSFFCCY EEQFPPGGAM MVMANVG--- -GLLFFWDPA AGGG-YRSSQ QIILLLGCCS SSSSSFFCCY PPQFPPDDGM MVKLDAG--- -GIFFFFEPK KGGG-HRPPQ QVVLLLGCCS SSSSSYYCCY EEQFPPKKGM MVKVDVN--- -GMFFFFDGE E----QRVVQ QIILLLGAAS SSSSSYYCCF EEQFPPRRGI IAKAEAD--- -GLLFFFEGD DGGG-LRPPQ QIILLLGSSS SSSSSYYCCY KKQF--IIRG GSVMLQVDDT TGLLFFLDGK KEEEPALAAE ELLYYYGCCS SSIIIWWII- KKQF--IIRG GSVMLQIDDT TGLLFFLDGK KEEEPALAAE ELLYYYGCCS SSIIIWWII- KKQF--IIRG GSVMLQIDDT TGLLFFLDGK KEEEPALAAE ELLYYYGCCS SSIIIWWLL- KKQF--IIRG GSVMLQIDDT TGLLFFLDGK KEEEPALAAE ELLYYYGCCS SSIIIWWLL- KKQF--IIRG GSVMLQVDDT TGLLFFLDGK KEEEPALAAE ELLYYYGCCS SSIIIWWII- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKQF--IIRG GSVMLQVDDT TGLLFFLDGK KEEEPALAAE ELLYYYGCCS SSIIIWWII- KKQF--IIRG GSVMLQIDDT TGLLFFLDGK KEEEPALAAE EIIYYYGCCT TTIIIWWLL- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKQF--IIKG GSVMLQIDDT TGLLFFLDGK KEEEPVLAAE ELLYYYGCCS SSIIIWWVV- KKQF--LLKG GAVMLQIDDT TGLLFFLDGK KEEEPVLAAE EIIYYYGCCT TTIIIWWII- KKQF--VVEG GSHILQIDDT TGLIFFFDGA AEEEPALAAE EMMYYYGCCT TTIIIWWII- KKQF--VVEG GSHILQIDDT TGLIFFFDGA AEEEPSLAAE EMMYYYGCCT TTIIIWWII- RRQF--MMDG GSHIIQIDDT TGLIFFFDGD DEEEPALAAE EMMYYYGCCT TTIIIWWII- VVSF--MMEG GSHIIQIDDT TGLIFFFDGD DEEEPSLAAE EMMYYYGCCT TTIIIWWII- EEQFGGVVKG GSHMLQIDDT TGLIFFFDGA AEEEPSLAAE EMMYYYGCCT TTIIIWWII- DDQF--VVKG GATMVQVNDP PGMIFFLDGK KIIIEYLAAE EMMYYYGCCT TTIIIWWII- DDQF--VVRG GATMLQIDDP PGMIFFLDGK KVVVPYLAAE EMMYYYGCCT TTIIIWWII- KKQF--VVKG GSVMLQIDDT TGLVFFLDGK KEEEPCLAAD DIIFFFCSST TTIIILLAA- KKQF--VVAG GGTIVQLDDV VGMLFFLDGG GEEEPGLPPE EMM------- ---------- KKQF--VVSG GGHIVLIDDT TGILFFLDAN NEEEPSLPPE EMMYYYGCCT TTIIIWWLLA ---------- ---------- ---------- ---------- ---------- ---------- --------KG GKDDAQYLAY YDKLFFADYE ELLLG-RAAI IMMFFFSLLY YY-------- --------KG GKDDEQFLLY YDKLFFADYA AEEEK-RPPQ QMMFFFALLY YYPPPAAGGD ------- ------- SSKKKR- SS----- SS----- ------- ------- SS----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- DD----- ------- ------- NNLLLVV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSAAAAAK KKPATPCRRT VVPPTTLLAA ALLAADDGGA AQQSLRTTTA AASSSLLLLG gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSRRIIAAYQ AAWWTTFFSS AAIQAAASSP PRSSGGKKKR RVPVVESSAA VAAAQVVQQA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MA RSAAPPTTPP PPLNTTTPPP PHPPAAAAAP PHPPPLRLVV RPPPRTIPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------IVVK RRRRDPTFPP PKMAAAMKKK ---------- ---------- ---------- ------MAAK PPPPDPTFPP PRDAAAMRRR ---------- ---------- ---------- -------MMR PPPPDPTFAA PELAAAMQQQ ---------- ---------- ---------- -------MMR PPPPDPTFAA PKLAAAMEEE ---------- ---------- ---------- -------MMR PPPPDPTFPP AKLAAAMEEE ---------- ---------- ---------- ------MAAK PPPPDPSFPP PRLAAAAKKK ---------- ---------- ---------- ------MVVR PPPPDPTFPP PRMAAAVKKK ---------- ---------- ---------- ------MAAR PPPPDPTFPP PKMAAAMQQQ ---------- ---------- ---------- ----MMCTT- CCCCGPGYTT LEAMMMK--- ---------- ---------- ---------- ---------- ---------- ------M--- AVWHWLLPPP GKAAAALIIA AAAAAARRLL LPG-HHCGG- CCCCGPGYSS LEAMMMK--- ---------- ---------- ---------- ---------- ---------- ---MMMK--- ---------- ---------- ---------- ----MMCGG- CCCCGPGYTT LEAMMMK--- -------AAE RAAAAFLQQS AAAAAAQQMM RPIATTCGG- CCCCGPGYTT LEAMMMK--- ---------- ---------- ---------- ----MMCGG- CCCCGPGYTT LEAMMMK--- ---------- ---------- ---------- ----MMCGG- CCCCGPGYTT LEAMMMK--- ---MGLLGGK EEHHHTQPPW LLLLLLSSQQ LWQETTCGG- CCCCGPGYTT QEAMMMK--- --LKNSSQQG CLDDDQNTTE HHHHHHTTCC TLVFSSCGG- CCCCGPGYTT LEAMMMK--- ---------- ---------- ---------- ----MMCGG- CCCCGPGYTT LEAMMMK--- RLCPHAARRH SLQQQHMEEG AAAAAAAAEE TAAANNCCCA KKKKGPGYTT LEAMMMEKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------CGG- CCCCGPGYSS LDAMMMK--- ---------- ------MAAT LLLLLLDDGG VVNEKKNGGK SSSSGPGYSS IESMMMS--- ---------- ------MGGT LLLLLLQQAA VVSEVVQGGK SSSSGPGYSS LEAMMMS--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------RMMV GGGGGPGYTT LAAMMMS--- ---------- ---------- ---------- MAAANNCCCA TTTTGPGYTT LEAMMMEKKK ---------- ---------- ---------- -MSPCCCHH- ----GPGYSS ADAIIIK--- ---------- ---------- ---------- -MP-CCCHH- ----GPGYSS ADAIIIK--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------ESSK CCCCGPGYTT LDAVVVRNNN ---------- ---------- ---------- ---------- ---------- ---MMMRSSS ---------- ---------- ---------- ---------- ----MPGLTT -DILLLISSS -----MMKKR RE-------- --------LL AAG-LLLPPA FFFFADETQQ PYMPPPKIII -----MMKKR FIGGGPMHHF LLLLLLRRLL VSGLLLAPPV RRRRADETAA PYMKKKKIII AEDAAYVAAY YTGTTGIIIA DFFIVNKSEI VHHHKVELPI NNLHHGGGGN SSAACCCCPN AEDAAYVAAY YVGTTGVVVP DFFLVDKSPV IYYYKLDLPI GGLHHGGGGN SSAACCCCPN AEEAAYTLLS SPDFFS---P DAALVKGSSI VHHHTVTMPT GGFHHGGGGN SSSSSSSSPL AENAAYTLLS SPDFFS---P DAALVKGSPI VHHHTVTMPK GGFHHGGGGN SSAASSSSPL GEKAAFTLLS SPDAAS---P DGGLVDTSEI VHHHQLIMPK GGFHHGGGGN SSAASSSSPL AETAAYVAAD DPERRK---P DAAIVDASPI VGGGQVAMPA GGLHHGGGGN SSCCCCCCPN AEKAAYVVVN NPMAANGGGP DAAMVDQSSV VGGGVTDMPT GGLHHGGGGN SSMMCCCCPN AERGGYVAAD DPGRRE---P DAALVDDSGI VGGGRVEMPA AALHHGGGGN AAAACCCCPY GEEVVYLPPY YRNTTGTTTP DYYLTDKSPV IHHHRLPMPL KKLHHGGGGN SSCC------ GEEVVYLPPY YRNTTGIIIP DYYLTDKSPV IHHHRLPMPL KKLHHGGGGN SSCC------ GEEVVYLPPY YGNTTGIIIP DYYLTDKSPV IHHHRLPMPL RRLHHGGGGN SSCC------ GEEIIYLPPY YRNTTGIIIP DYYLTDKSPV IHHHRLPMPL KKLHHGGGGN SSCC------ GEEVVYLPPY YRNTTGTTTP DYYLTDKSPV IHHHRLPMPL KKLHHGGGGN SSCC------ GEEVVYLPPY YRNTTGTTTP DYYLTDKSPV IEEE------ ---------- ---------- G--------- ------TTTP DYYLTDKSPV IHHHRLPMPL KKLHHGGGGN SSCC------ GEEVVYLPPY YRNTTGTTTP DYYLTDKSPV IHHHRLPMPL KKLHHGGGGN SSCC------ GEEVVYLPPY YRNTTGTTTP DYYLTDKSPV IHHHRLPMPL KKLHHGGGGN SSCC------ GEEVVYLPPY YRNTTGTTTP DYYLTDKSPV IHHHRLPMPL KKLHHGGGGN SSCC------ GEEVVYLPPY YRNTTGTTTP DYYLTDKSPV IHHHRLPMPL KKLHHGGGGN SSCC------ GEKVVYVTTY YNGTTGIIIL DYYLTDSSPV IHHHRLPVII GGLHHGGGGN SSCC------ ---------- ---------- ---------- -------MPT NNLHHGGGGN SSCC------ GEEVVYLPPY YRSTTGIIIP DYYLTDKSPV IHHHRLPMPV NNLHHGGGGN SSCC------ GESIIYVTTY YAGTTGIIIP DYYLTDSSPV IHHHRLPVPV GGLHHGGGGN SSCC------ GETIIYVTTY YAGTTGIIIP DYYLTDNSPV IHHHRLPVPV GGLHHGGGGN SSCC------ ---------- ---------- ---------- -------MPV GGLHHGGGGN SSCC------ GEKIIYVTTY YTGTTGIIIP DYYLTDSSPV IHHHRLPMPV GGLHHGGGGN SSCC------ GEKLLYVTTY YNGTTGIIIP DYYLTDNSPV IHHHRLPVTV GGLHHGGGGN SSCC------ GEELLFVTT- ---NNAAAAP DAAITNESDV ISSSRVDVPI GGVHHGGGGN SSCC------ GEELLFVTT- ---HHARRRP DAAITNESEI ISSSRVDVPI GGVHHGGGGN SSCC------ ---------- ---------- ---------- ---------- ---------- ---------- GEKLLYVVVQ QPNLLDEEEG DYYLTDASPV IHHHRTYTNK HHLHHGGGGN SSCCFFFFP- GEKLLYTVVQ QPNLLDEEEG DYYLTDESPI VHHHRTFTNK GGLHHGGGGN SSCCYYYYDE LRFYYFSNNH HGDIIRQQQI TDDRNVQVFV LKKKDGPVKL EEELLQQQQT LLKK------ TEEVVYVWWG GVEGGMGGGQ DKKLTRGSAV INNNSVSVG- RRAHHGGGGS ---------- TEDVVYVWWG GAEGGVGGGQ DKKLTNKSPV VNNNTLSVG- RRAHHDDDDT ---------- NGGIIIRRIV GSSSRIIDPP EPKKIIIKKV IIIEPEEKKK VSYYYYSLHT HCCGPPDDAA NAALLLRRIV ASSSRIIDPK RPAAVVAKKI VVVEPVVVGG RTYYYYTYHT HCCGPPDDAA LTTLLLRRII GSSSRVVDPP QARRIIHKKI IIIEPEELAA KTYYYYSPHT HCCGPPEEGG LAAIIIRRII GSSSRIIDPP KAKKIIHKKI IIIEPEEFKK KTYYYYSPHT HCCGPPDDGG LTTLLLRRII GSSSRIID-P KAKKIIHKKI IIIEPEEFAA KTYYYYSPHT HCCGPPEEGG NAAMMMRRVV GSSSRIIDPP KPFFLLAKKV IIIEPTTAEE RTYYYYSPHT HCCGPPGGGG NAAVVVRRVV DSSSHIIDPP QPKKVVVKKV IIIDPEEAEE RTYYYYAPHT HCCGPPDDGG YAAVVVRRIV GSSSRIIDPP EPRRIIVKKV IIIEPEEHRR RTYYYYSPHT HCCGPPDDGG -FFKKKRNIL GSSSRVVDSP APKKLLHKKV IIIEAEEQAA KCVVVVSTHT HCCLAASSGG -FFKKKRDIL SSSSRVVDSP APKKLLHKKV IIIEPEEHAA KCLLLLGLHT HCCLAASSGG -FFKKKRTML CSSSRVVDSP APKKLLHKKV IIIEADDHAA KCLLLLGVHT HCCLAASSGG -YYKKKRTVL ASSSRVVDTP APKKLLHKKV IIIEPDDHTT KCLLLLGFHT HCCLPPSSGG -FFKKKRTVL SSSSRVVDSP APKKLLHKKV IIIEPDDHAA KCLLLLALHT HCCLAASSGG ---------- ---------- ---------- ----PDDHAA KCLLLLALHT HCCLAASSGG -FFKKKRTVL SSSSRVVDSP APKKLLHKKV IIIEPDDHAA KCLLLLALHT HCCLAASSGG -FFKKKRTVL SSSSRVVDSP APKKLLHKKV IIIEPDDHAA KCLLLLALHT HCCLAASSGG -FFKKKRNVL SSSSRVVDTP APKKLLHKKV IIIEADDHEE KCLLLLGPHT HCCLPPTTGG -FFKKKRTVL S--------- ---------- ---------- ---------- ---------- -FFKKKRTVL SSSSRVVDSP APKKLLHKKV IIIEPDDHAA KCLLLLALHT HCCLAASSGG -HHAAARRIL SSGGRVVDTP TPSSLLHKKV VVVESDDAEE NILLLLGPHT HCCLAASSGG -YYKKKRNIL CSSSRVVDTP APRRIIHKKT VVVEPEEFWW KCLLLLALHT HCCLGGCCGG -YYKKKRNIL CSSSRVVDSP APRRIIHKKT VVVEPEEFWW KCLLLLAPHT HCCLGGCCGG -HHAAARRIA SSGGRVVDTP SPSSLLHKKV VVVDPDDIQQ KTLLLLAPHT HCCLAASSGG -HHAAARRIV GSGGRVVDTP APSSLLHKKV VVVEPDDSTT KTLLLLAPHT HCCLAASSGG -HHAAARRVL SSGGRAADEP APSSLLYKKY VVVDPEEAEE KTLLLLAPHT HCCLAASSGG -HHVVVRRVL SSGGRAADEP APSSLLYKKY VVVDPEEADD KTLLLLAPHT HCCRTT--GG -HHAAARRIL SSGGRVVDKP APAALLHKKV VVVEADDAEE KTLLLLGPHT HCCLAASSGG -HHEEERSIV CSDDRIINN- KIYYLLEHHT IIIEPKKHSS LNLLLLSPHT HCCLAADDGG -HHEEERSIV CSDDRVVNN- EIYYLLQHHT IIIEPKKHAA LNLLLLSPHT HCCLAADDGG --------VP KSGGVKKFG- ---------- ---------- ---------- ---------- -GGPPPRDVL CSDDRVVDTP APKKLLAKKV IIIEGDDLKK GACCCCTPHT HCCLPPNNGG ESSPPPRDVL SSDDFIIDTP KPEEIIVKKT IIIDGDDLKK SHVVVVTPHT HCCLAANNGG ---QQQGPLQ SGKKRVVTYA DKQQFFYPP- -----DDIKK FLLLLLASHT DYYQPPNNTT ------RRWT GTNNRIIDSP NPKKLLHKKT IIIDTFFKDD SGVVVVVPHT FAALPPGGSS ------RRWA GTSSKVVDSP RPVVLLSKKT IIITDFFEKK SGVVVVVPHT YAALPPGGRR IIISGNNEE- --E---GGII LMLDDHYYFF EPLWWEIGGD Y--------- ---AYYDFFW IIISGGGPP- --DRRRGGII FLLDDHDDFF EPIWWEVGGP Y--------- ---AYYDFFW IIVSGGGAAK KKDTTTGPII FIMDDCEEFF DVLWWEIGGP D--------- ---HYYDFFW IIVSGGGGGK KKDTTTGPVV FIMDDCEEFF EVLWWEIGGP T--------- ---HYYDFFW IIVSGGGGGE EEDTTTGPII FILDDCEEFF EILYYEMGGE T--------- ---HYYDFFW IIVTGNNAA- --E---GGII AMLDDAQQFF EPLWWEVGGP Y--------- ---AYYDGGW IIISGSSPP- --E---GGII FILDDHDDLL EVLWWEIGGD Y--------- ---HYYDFFW VVVSGSSPP- --E---GGVV FVMDDHEEFF DPLWWEVGGP Q--------- ---AYYDFFW EEMVLGGDD- --LGGGGGFF VLLDDGEEFF EVKWWEKGGA P--------- ---GYYDFFW EEMILGGDD- --PGGGGGFF VLLDDGEEFF EVKWWEKGGE P--------- ---GYYDFFW EEMILGGDD- --SGGGGGFF VLLDDGEEFF EVKWWEQGGA P--------- ---GYYDFFW EEMVLGGDD- --PGGGGGFF VLLDDGKKFF EVKWWEQGGA P--------- ---GYYDFFW EEMILGGDD- --VGGGGGFF VLLDDGEEFF EVKWWERGGA P--------- ---GYYDFFW EEMILGGDD- --VGGGGGFF VLLDDGEEFF EVKWWERGGA P--------- ---GYYDFFW EEMILGGDD- --VGGGGGFF VLLDDGEEFF EVKWWERGGA P--------- ---GYYDFFW EEMILGGDD- --VGGGGGFF VLLDDGEEFF EVKWWERGGA P--------- ---GYYDFFW EEMILGGDD- --PGGGGGFF VLLDDGEEFF EVKWWERGGS P--------- ---GYYDFFW ---------- ---------- ---------- ---------- ---------- ---------- EEMILGGDD- --VGGGGDSS LVLLLP--LL ECS------- ---------- ---------- DDMILGGDD- --KGGGAGGG FLLLLDSSFF NVKGGSNFFP S--------- ---ERRTHHL EEMIIGGDD- --PGGGGGFF VLLDDGEEFF EVKWWEAEEA P--------- ---GYYDFFW EEMILGGDD- --PGGGGGFF VLLDDGEEFF EVKWWEVEES Q--------- ---GYYDFFW EEMILGGDD- --KGGGAGGG FLLLLDSSFF NVKWWEKHHS L--------- ---GYYDFFW EEMIIGGDD- --KGGGAGGG FLLLLDSSFF NVKWWEKHHS L--------- ---GYYDFFW EELVLGGDD- --EGGGAGGG FLLLLDSSFF NIKWWEKHHS L--------- ---GYYDFFW EELVLGGDD- --EGGGAGGG LLLLLDSSFF NIKWWEKIIS L--------- ---GYYHFFW EEMILGGDD- --KGGGAGGG FLLLLDSSFF NVKWWEKHHS L--------- ---GYYDYYW NNMILGGEE- --AGGGPGFF LLLDDGKKFF EPKWWPAKKT P--------- ---NYYDFFW NNMILGGEE- --AGGGPGFF LLLDDGKKFF EPKWWPAKKV P--------- ---NYYDFFW ---------- ---------- ---------- ---------- ---------- ---------- NNMIMGGDD- --AGGGAGDD FVEFFDKKFF ELVWWSRRRK L--------- ---GYYDYYW NNMIMGGDD- --AGGGAGDD FILFFDSSFF NCIWWTKKKK L--------- ---GYYDFFW AAKQVNNEE- --SSSSPLGG IQTSSKHHNN GLSGGEAFFE I--------- ---QLLSNNH MMITSNNDD- --DHHHGTLL VEYNNDDDEE YVAWWMPDDD QGVVAAAAVV VADGYYDIIR MMITSNNNN- --KHHHGTLL VEYTTNAAEE YVAWWIPGGD RGIIKKKKYY YADDYYDVVR WWNNNNNNEV VWWAAVVVPN ---TIIIEED -KLLLHDYGG HFFDRKRRRI HHHHLLLLLT WWNNNSSSGI IWWTTVVVPR ---CFFFEEE -SLLLCEYGG HVVDAKRRRL YYYYIIIIID WWNNNRRRDV VWWAALLLPP ---QFFFEEN -VPPPDAYGG HFFDRARRRV QQQQIIIIID WWNNNRRRDV VWWAALLLPP ---QFFFEEN -VPPPDSYGG HFFDRARRRV QQQQIIIIID WWNNNRRRDV VWWGGLLLPP ---QFFFEEN -VPPPDSYGG HFFKRDRRRV QQQQIIIIID WWHHHYYYDV VWWGGTTTPD ---MVVVEED -VPPPIGYGG HFFDTRRRRL QQQQIIIIID WWHHHYYYDL LWWGGTTTPR ---MVVVEES -LGGGEAYGG HVVDYRRRRL QQQQLLLLLD WWHHHYYYDV VWWGGTTTPN ---MIIIEEG -DPPPINYGG HIIDRRRRRL QQQQLLLLLD WWQQQHHHNV VWWAAAAAPN ---VFFFKKD FPAAAV-YGG FVVDQRHHHI QQQQLLLLLQ WWQQQHHHNV VWWAAAAAPN ---VFFFKKD FPAAAV-YGG HVVDQRHHHI QQQQLLLLLQ WWQQQHHHNI IWWAAAAAPN ---VFFFRRD FPAAAV-YGG HVVDQRHHHI QQQQLLLLLT WWQQQHHHNI IWWAAAAAPN ---VLLLRRD FPAAAV-YGG YVVDQRRRRV QQQQLLLLLP WWQQQHHHNI IWWAAAAAPN ---VLLLRRD FPAAAV-YGG YVVDQHHHHV QQQQLLLLLS WWQQQHHHNI IWWAAAAAPN ---VLLLRRD FPAAAV-YGG YVVDQRHHHV QQQQLLLLLS WWQQQHHHNI IWWAAAAAPN ---VLLLRRD FPAAAV-YGG YVVDQRHHHV QQQQLLLLLS WWQQQHHHNI IWWAAAAAPN ---VLLLRRD FPAAAV-YGG YVVDQRHHHV QQQQLLLLLS WWQQQHHHNI IWWAAAAAPN ---VVVVQQN FPAAAV-YGG HVVDQRHHHV QQQQLLLLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- -SSAAHHHSN ---LRRRLLT SDYYYA-VAA ---------- ---------- LLEEEWWWGW WQQCCCCCSL ---FYYYTTT ALMMML-VHH CLLNIMRRRD EEEELLLLLP WWQQQHHHNI IWWGGAAAPK ---AFFFAAL FMEEEV-YGG NVVDTEHHHI QQQQIIIIID WWQQQHHHNI IWWGGAAAPK ---AFFFAAL FMEEEV-YGG NVVDTEHHHV QQQQIIIIID WWQQQHHHNI IWWGGAAAPT ---AFFFTTK FLQQQV-YGG TCCQARGGGR QQQQLLLLLD WWQQQHHHNI IWWGGAAAPK ---AFFFLLQ FLQQQV-YGG HVVSPGGGGK QQQQLLLLLD WWQQQHHHKI IWWGGAAAPK ---AFFFSSK FLQQQV-YGG HVVSPGGGGK QQQQIIIIID WWQQQHHHKI IWWGGAAAPK ---AFFFSSK FLQQQV-YGG HVVSPGGGGK QQQQIIIIID WWQQQHHHKI IWWGGAAAPA ---AFFFRRT FLQQQV-YGG HVVDPGGGGK QQQQLLLLLD WWQQQRRRNI IWWGGSSSPN ---HIIIKKK FPAAAV-YGG HIIEDSKKKL QQQQIIIIID WWQQQRRRNI IWWGGSSSPN ---HIIIKKK FPAAAV-YGG HIIEDTKKKL QQQQIIIIID ---------- -RRGGGGGPV ---TVVVCCR ELKKKQ-VII RVV------- ---------- WWQQQFFFNV VWWGGAAAPK ---LFFFRRR YPTTTCRYGG NFFRQERRRF QQQQIIIIID WWQQQFFFDV VWWGGAAAPN ---KWWWRRR WNVVVLMYGG NFFKSTQQQY QQQQIIIIID HHNNNRRREE EPPDDEEEPI ---MAAAFFE SSFFFKGKPP AEEL------ ---------- RRLLLKKKNL LFFTTGGGWS NNNMMMMDDF QLQQQAMFGG VQQDHTRRRK KKKKFFFFFN RRLLLKKKNV VFFTTGGGWN NNNMMMMDDF KLAAAPMFGG VTTDHTKKKK KKKKFFFFFD LEENMAL--- ----ELDTTT KLLLMMGGII IMVVVSLLKK DSSSWLLWYE WNEEEKVIII LQEHMVL--- ----ELDTTT KLLLMMGGVV VVVVVNTTKK DSSSWLLWYE WQEEERVIII LAQHMAL--- ----EADVVV REEEYYGGVV VVVVVDTTTT NESSWTTWRE FHKKKKTAAA LANHMAL--- ----EADVVV REEEYYGGVV VVVVVDTTTT NESSWTTWRE FHEEEKTAAA LANHMAL--- ----EADSSS KDDDYYGGCC CVVVVDTTTT NQAAFTTWQD FEKKKKTIII FDEHLVF--- ----EADTTT KAAAYYGGVV VCVVVSLLKK DSSSWTTWRD WARRRKVIII LAEYMAL--- ----EADTTT KAAAYYGGMM MCVVVSLLKK DSSSWLLWRD WHKKKKVIII VEEHMVL--- ----EADAAA RTTTYYGGVV VVVVVSLLEE DSSSWLLWRQ WGRRRKVIII M--DLIP--- -LLLELDSSS ATTTQQGGVV VCAAASSSNN IRYYNEEE-- -------TTT M--DLIP--- -LLLELDDDD ATTTQQGGVV VCAAASSSNN IRYYNEEG-- -------TTT L--DLIP--- -LLLELNDDD AAAAQQGGVV VCAAASSSTT IRYYNQQG-- -------TTT L--DLIP--- -LLLELNDDD AAAAQQGGVV VCAAASSSTT IRFFNEED-- -------TTT L--DLIP--- -LLLELNDDD AAAAQQGGVV VCAAASSSTT IRYYNEEG-- -------TTT L--DLIP--- -LLLELNDDD AAAAQQGGVV VCAAASSSTT IRYYNEEG-- -------TTT L--DLIP--- -LLLELNDDD AAAAQQGGVV VCAAASSSTT IRYYNEEG-- -------TTT L--DLIP--- -LLLELNDDD AAAAQQGGVV VCAAASSSTT IRYYNEEG-- -------TTT M--DHIP--- -LLLELDAAA ASSSQQGGVV VCAAASSSTT IRYYNEEG-- -------TTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- L--DAGANNP ILLLCIWNNN INNNQQDDDD DVEEESFFSS GGSSPDDA-- -------AAA LE-DLIP--- -LLLELDDDD AAAAQQGGVV VCAAASSSTT VRYYEKKD-- -------KKK LK-DLIP--- -LLLELNDDD ADDDQQGGVV VCAAASSSSS IRYYEKKD-- -------KKK LN-TLLP--- -LLLELDAAA KDDDTTGGVV VSAAASSSNN MRFFTQQD-- -------SSS LD-KLLP--- -LLLELDAAA KDDDTTGGVV VSAAATSSNN MRFFTQQD-- -------SSS LE-TLLP--- -LLLELDSSS KDDDTTGGVV VSAAASSSNN MRFFNSSD-- -------TTT LP-TLLP--- -LLLELDSSS KDDDTTGGVV VSAAASSSNN MRFFNSSD-- -------TTT LS-TLLP--- -LLLELDSSS KDDDTTGGVV VCAAATSSNN MRFFTAAD-- -------SSS LQPLALP--- -LLLELETTT SEEEHHAAVV VCAAAGSSGG IRHHVEEES- -----T-TTT LMPRALP--- -LLLELETTT SEEEHHAAVV VCAAAGSSAA IRHHDEEKP- -----K-VVV ---------- ---------- ---------- ---------- ---------- ---------- LD-DLTP--- -LLLELNRRR ENNNQQGGVV VCAAAXXXXX XXXX------ ---------- LS-DITP--- -LLLELNKKK KAAAEEGGVV VCAAANAAKK VHKKKSSDD- -----EFEEE ---------- ---------- ---------- ---------- ---------- ---------- VGAP------ -LLLEPGNNN ANNNYYAASS STAAATSSQQ LLYYDDDA-- ---------- VGAP------ -LLLEAGAAA HNNNYYCCTT TTAAATSSQQ LLYYDGGE-- ---------- IIPPEPLLLL EGNPEIIKKK FFVVVVVTDD DDKFLLSLGG IGGEVRQQYY SNNPFFKPVT IIEEQPFFFF EGPPPVVKKK FFVVVVVTDD DDRFLLSLGG LGGELRQQYY TNNPHHQPRA AIPPEPAAAA TAEPPLLQQQ FFVVVVVTDD DDRFLLSCGG TGGEMRQQYY SDDPHHNPVA AIPPEPAAAA PKKPPLLQQQ FFVVVVVTDD DDRFLLSCGG TGGEMRQQYY SDDPRRKPKA IIDDVPAAAA DADPDLLKKK FFCCCCCTDD DDKYLLACGG LGGEMHQQYY SDDPMMNPVT IIPPEAAAAA DPQPPVVKKK FFVVVVVTDD DDRFLLSCGG TGGDLLQQYY SDDPFFEPKT IIPPEPAAAA SEQPPIIKKK FFVVVVVTDN DDRFLLSCGG TGGELHQQYY SDDPFFNPRT IIPPEPAAAA EPQPPLLKKK FFVVVVVTDN DDRFLLSCGG TGGELRQQYY SDDPFFNPRT TSVVKVIIII QVSKVKKWWW LLMMMMMTDL DDRFLLSNLL HGGDIRQQYY SNNPQQKPRT TSVVKVIIII QVSKVKKWWW LLMMMMMTDL DDRFLLSNLL HGGDIRQQYY SNNPKKKPRT TSVVKVIIII QVPKVKKWWW LLMMMMMTDL DDRFLLSNLL HGGDLRQQYY SDDPQQRPRT TSAAKVIIII QVPKVKKWWW LLMMMMMTDL DDHFLLSNLL HGGDIRQQYY SDDPQQRPRT TSVVKVIIII QVPKVKKWWW LLMMMMMTDL DDRFLLSNLL HGGDLRQQYY SDDPQQRPRT TSVVKVIIII QVPKVKKWWW LLMMMMMTDL DDRFLLSNLL HGGDLRQQYY SDDPQQRPR- TSVVKVIIII QVPKVKKWWW LLMMMMMT-- ---------- ---------- ---------- TSVVKVIIII QVPKVKKWWW LLMMMMMTDL DDRFLLSNLL HGGDLRQQYY SDDPQQRPRT TSVVKVIIII EVPKVKKWWW LLMMMMMTDL DDRFLLNNLL HGGDMRQQYY SDDPKKRPRV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AVLLRKLLLL DLYVVAAFFF VVLLLLLPPW SSLLIILS-- ---------- ---------- KAAAKVIIII KVSKVEEWWW LLMMMMMTDL DDRFLLSNLL HGGDIRQQYY TDDPRRNPKV KAAAKVIIII QVSKVEEWWW MMMMMMMTDL DDRFLLSNLL HGGDIRQQYY TDDTRRNPKV SSHHLAIIII PVPKVQQWWW LLMMMMMTDL DDRFLLVNLL HGGDIRQQYY EDDLKKNPVT SNHHIVIIII SVPKVQQWWW LLMMMMMTDL DDRFLLVNLL HGGDIRQQYY EDDVKKNPKT TSYYIVIIII SVPKVEEWWW LLMMMMMTDL DDRFLLVNLL HGGDIRQQYY EDDPKKNPVT TSHHVVIIII SVPKVEEWWW LLMMMMMTDL DDRFIIVNLL HGGDIRQQYY EDDPKKNPVT SSHHVAIIII SIPKVRRWWW LLMMMMMTDV DDRYLLVNLL HGGDIRQQYY EDDPAAKPVA TAAALVAAAA FISKVSSWWW LLMMMMMTDL DDRFLLSCLL HGGDIRQQYY SDDPLLKVKN VTAALVAAAA TISKVEEWWW LLMMMMMTDL DDRFLLSCLL HGGDIRQQYY SDDPKKNPKN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---QGEEGGG IIMMMMMTDL DDRYLLSNRR HGGDVRQQYY SDDRAANPRT EKKKIDIIII PGLDTGGGGG AAMMMMMSDI DDRFLLNCRR HGGDVRQQYY TDDPEENPKT ---------- ---------- ---------- ---------- ---------- ---------- ---------- EWAAVAAIII NNDDDDDVDS DDQTLLNSMM DGGKTRLLFF SDDPHHKPFI ---------- EWAAVAAIII EEKKKKKVDS DDSRLLNTMM DGGKTRLLFF SDDPHHHPRV GKVVVKLLGI FFHHDDHHPP ---------- -----AGHTA QQLLEEEEEE IIIIISSSDD GRVVVKIIGL YYHHPPHHPP ---------- -----SGATA QQIISSSSSS VVVVVSSSDD GSVVVRIIGI AARRPPHHPP ---------- -----NGRAG QQVVEEEEEE IIIIISSSDD GSVVVHIIGI AARRPPHHPP ---------- -----NGKAG QQVVEEEEEE IIIIISSSDD GKVVVEIIGI VVKKPPHHPP ---------- -----NGKGG QQVVEEEEEE IIIIISSSDD GKVVVRIIGI VVSSTTHHPP GG-------- -----KNGNG QQVVEEEEEE IIIIISSSDD GKVVVQIIGI VVRRGGHHPP ---------- -----TSANG QQVVEEEEEE IIIIISSSDD GSVVVRLLGI VVRRAAHHPP ---------- -----ASGNG QQVVEEEEEE VVVVVSSSDD GQIIIFLLGS IIVVGGSSVV QQVVE-QELT TCQEEKGKPG QQIIQQQQQQ LLLLLSSSDD GQIIIFLLGS IIVVGGSSVV QQVVE-QELT TCQEEKGKPG QQIIQQQQQQ LLLLLSSSDD GQLLLFLLGS IIVVGGPPVV QQVVE-QELK KSQEEKGKPG QQIIQQQQQQ LLLLLSSSDD GQLLLFLLGS IIVVGGPPVV QQVVD-QELD DSQEEKGKAG QQIIQQQQQQ LLLLLSSSDD GQLLLFLLGS IIVVGGPPVV QQVVE-QELK KSQEEKGKAG QQIIQQQQQQ LLLLLSSSDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GQLLLFLLGS IIVVGGPPVV QQVVE-EELK KSQEEKGKAG QQIIQQQQQQ LLLLLSSSDD GQIIIFLLGS IIVVGGPPVV QQVVE-QELK KSQEEKGKPG QQIIQQQQQQ LLLLLSSSDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GQIIIFLLGS IILLGGPPVV TTVVE-KDLE ECQDDKGKPG QQIIQQQQQQ LLLLLSSSDD GQIIIFLLGS IIQQGGPPVV TTVVE-KELE ECQDDKGKPG QQIIQQQQQQ LLLLLSSSDD GQLLLWVVGL IIQQSSPPVV AAAAG-DGKT TWQDDQGQRG QQIIQQQQQQ LLLLLTTTDD GQVVVWAAGL IIQQSSPPVV VVAAK-DGET TWQDDQGKRG QQIIQQQQQQ LLLLLSSSDD GQIIIWVVGL LLQQSSPPVV KKAAG-DGNS SFQDDKGKRG QQIIQQQQQQ LLLLLSSSDD GQIIIWVVGL LLQQSSPPVV KKAAG-DGNT TFQEEKGKRG QQIIQQQQQQ LLLLLSSSDD GQVVVWAAGL LLQQSSEEVV VVYYT-DDKE EEQSSKGHRG QQIIQQQQQQ LLLLLSSSDD SQVVVYIIGS VVHHSSNNVV KKVVE-EK-- --PEEKGREG QQLLQQQQQQ LLLLLSSSDD SQVVVFIIGS IIHHTTTTVV KKVVE-DHD- --EPPKGREG QQLLQQQQQQ LLLLLSSSDD ---------- ---------- ---------- ---------G AAIIQQQQQQ LLLLLSSSDD GQVVVFLLGA IIQQAAPPRR RRVVN-PELK KEAEEKGRLG QQLLQQQQQQ LLLLLSSSDD GQLLLFLLGA IICCLLPPNN VVIIKEKELK KERPPKGREG QQLLQQQQQQ LLLLLSSSDD ---------- ---------- ---------- ---------- ---------- ---------- YEKKKVIIRQ VVNN------ ---------- ---------- --VVSSSSSS QQQQQSSSDD YEKKKTIIAQ VVNN------ ---------- ---------- --VVSSSSSS SSSSSSSSDD RRRVTTNSLL LWDDQFFEEE GWWWVVKKKN N---GGGGDK VGE--AAQLL SGGGDASSSD RRRVTTNSLL LWNNQFF--- GWWWAAKKKN N---GGGGEK VGR--AAQLL WGGGDASTTD RRRVTTNSLL LWDDQFFDDD AAAAVVLLLH G---GGGGAD VPDG-YYQLL EGGGDCSTTD RRRVTTNSLL LWDDQFFDDD GVVVVVMMMN G---GGGGDK VPDG-YYQLL EGGGDCSTTD KKRVTTNSLL LWDDQFFGGG AAAAVVMMMN G---GGGGDK VPAG-YYQLL EGGGDCSTTD RRRVTTNSLL LVDDQFFEEE GWWWVVKKKD G---GGGGDP LPKG-HHQLL QGGGDCSSSD RRRVTTNSLL LWDDQFFDDD GWWWVVKKKD N---GGGGDP VGE--QQQLL QGGGDASSSD RRRVSSNSLL LWDDQFFVVV GWWWAAKKKE D---GGGGDP TGDG-LLQLL EGGGDSSSSD KKRLTTTSLL LWDDQFFPPP REEESSVVVL VDDTGGGGNP VGKEPAAEYY PGGGDCSSSD KKRLTTTSLL LWDDQFFPPP REEESSVVVL IDDTGGGGNP VGKEPAAEYY PGGGDCSSSD KKRLTTTSLL LWDDQFFPPP REEESSVVVL IDDTGGGGNP VGKEPAAEYY PGGGDCSSSD KKRLTTTSLL LWDDQFFPPP REEESSVVVL IDDTGGGGNP VGKEPAAEYY PGGGDCSSSD KKRLTTTSLL LWDDQFFPPP REEESSVVVL VDDTGGGGNP VGKEPAAEYY PGGGDCSSSD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKRLTTTSLL LWDDQFFPPP REEESSVVVL VDDTGGGGNP VGKEPAAEYY PGGGDCSSSD KKRITTTSLL LWDDQFFPPP REEESSVVVL IDDTGGGGNP VGKEPAAEYY PGGGDCTSSD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKRLTTNSLL LWDDQFFPPP KEEESSVVVL IDDTGGGGNP VGKEPVVEYY PGGGDCSSSD KKRITTSSLL LWDDQFFPPP KEEEAAVVVL IDDTGGGGNP VGKEPVVEYY PGGGDCTSSD KKRLTTNSLL LWDDQFFPPP EKKKSSHHHL IDDTGGGGNP VGAEPAAEYY PGGGDCTSSD KKRLTTNSLL LWDDQFFPPP EQQQSSHHHL IDDTGGGGNP VGAEPSSEYY PGGGDCTSSD KKRLTTNSLL LWDDQFFPPP DKKKSSHHHI IDDTGGGGNP VGDEPAAEYY PGGGDCTSSD KKRLTTNSLL LWVVSFFPPP EKKKSSHHHI IDDTGGGGNP VGDEPSSEYY PGGGDCTSSD KKRITTNSLL LWDDQFFQQQ KKKKSSHHHL IDDTGGGGNP VGAEPSSEYY PGGGDCTSSD KKRLTTTSLL LWDDQFFPPP KSSSAATTTV VNDPKKKKNR IGKIEYYEYY PGGGDCTSSD KKRLSSTSLL LWDDQFFPPP RSSSAATTTL IDDPHHHHNK IGKVPYYEYY PGGGDCTSSD KKRLTTNSFF FWDDQFFPPP KEEESSVVVL IDDTGGGGNK VGKEPCCDFF PCGGDSTSSD RRRLSSSSLL LWDDQFFPPP AAAAGGTTTV LDDVGGGGNE VGGEPGGE-- ---------- KKRLSSSSLL LWDDQFFPPP SQQQGGHHHV IDDTGGGGNE VANEPSSEYY PGGGDCTSSD ---------- ---------- ---------- ---------- ---------- ---------- KKRVSSSSLL LWDD------ KKKKKKDDDA YLAYGGGGVE VYELG--IFF GSSSALYSSS QQRLTTSSLL LWDD------ KKKKKKDDDE FLLYGGGGKE IYAEK--QFF GARRALYAAG SSPP--- SSPP--- SSPPSVR SSPPSV- SSPPSV- SSPP--- SSPP--- SSPPS-- II----- II----- II----- II----- II----- ------- ------- II----- II----- ------- ------- ------- II----- II----- II----- II----- II----- II----- II----- II----- II----- II----- ------- IINNDA- ------- ------- PPGGNRV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMMSKAAKKK QPAAPPTTTA VVVTGAAARL LGASLLRRTT LSSLLTTPPS SVRIIKKKYQ gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- --------MA gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QAAAATFIIQ QAAASSRRGT RPPLVESSSA AKKQVVSQAA AVVVVWAAAW WWLLLPPPGK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----AAARA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------G GGLLLGGGEE ---------- ---------- ---------- ---------- -----LLLLN NNSSSQQQCL ---------- ---------- ---------- ---------- ---------- ---------- ARSSSPTLLN NTTTPPHHAS PPPVPLRLLP PYYRTIVPPP RLLLLCPPPH HHAAARRRSL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMMKKKRE ---------- ---------- ---------- ---------- ---------- --MMMKKKFI ---------- -------MAI VVFFRRPFFY SSPPKMMMAP EYVVVVAALT GGGIINNRAA ---------- ---------M AALLPPPFFY TTPPRDDMAP EYVVVVAALV GGGVVNNAPP ---------- ---------- MMMMPPPFFH SSPPELLMAA EYTTTTLLLP DSS----RPP ---------- ---------- MMMMPPPFFH SSPPKLLMAA EYTTTTLLLP DSS----KPP ---------- ---------- MMLLPPPFFY SSAAKLLMGV EFTTTTLLLP DSS----KPP ---------- ---------M AAWWPPPFFY SSPPRLLAAP EYVVVVAAFP EKK----QPP ---------- ---------M VVWWPPPFFY SSPPRMMVAA EYVVVVVVLP MNNGG--KPP ---------- ---------M AAWWPPPFFY SSPPKMMMAR EYVVVVAALP GEE----RPP ---------- ----MAATKC TT--CCPYYP PPLLEAAKGR EYLLLLPPIR NGGTTEEAPP ---------- ---------- ---------- -------MGR EYLLLLPPIR NGGIIEEAPP HAAPRGLPPG --AAHSSTQC GG--CCPYYP PPLLEAAKGR EYLLLLPPIG NGGIIEEAPP ---------- ---------- ---------- -------KGR EYLLLLPPIR NGGIIEEAPP ---------- ----MAATKC GG--CCPYYS PPLLEAAKGR EYLLLLPPIR NGGTTEEAPP EAFVQPMPPI AASSTAATKC GG--CCPYYS PPLLEAAKGR EYLLLLPPIR NGGTTEEAPP ---------- ----MAATKC GG--CCPYYS PPLLEAAKG- ---------- ---TTEEAPP ---------- ----MAATKC GG--CCPYYS PPLLEAAKGR EYLLLLPPIR NGGTTEEAPP PHTFSGQWWQ EEDDTAATKC GG--CCPYYP PPQQEAAKGR EYLLLLPPIR NGGTTEEAPP GDQLTYCLLV FFTTSPPTKC GG--CCPYYS PPLLEAAKGR EYLLLLPPIR NGGTTEEAPP ---------- ----MAATKC GG--CCPYYS PPLLEAAKGR EYLLLLPPIR NGGTTEEAPP VQHAAVEAAA AAAANGGKTC CCTTKKPYYA PPLLEAAEGR EYVVVVTTVN GGGIINNKLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMAKC GG--CCPYYK PPLLDAAKGR EYLLLLPPIR SGGIINNKPP ---VDHGVVN EEKKKSS-VN GGCCSSPYYA PPIIESSSGR EYVVVVTTVA GGGIIEEKPP ---VQHAVVS EEKKVNNNQQ GGCCSSPYYA PPLLEAASGR EYVVVVTTVA GGGIIEEKPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R MMQQGGPYYA PPLLAAASGS EYVVVVTTVT GGGIIDDKPP -------AAA AAAANGGAAC CCGGTTPYYA PPLLEAAEGR EYVVVVTTVN GGGIINNKPP -------MMS PPNNCGGLKC HH----PYYA PPAADAAKGR EFVVVVTTP- -AAAADDGPP -------MMP ----CPPLKC HH----PYYA PPAADAAKGR EFVVVVTTP- -AARRDDGPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MSE SSCCCCPYYA PPLLDAARGV EYVVVVVVVP NDDEEEEHGG ---------- ---------- ---------- -------RGR EYTTTTVVVP NDDEEPPHGG ---------- ---------- ------PLLI ----DIIILD RFSSSSNNLG DRRQQYYDII F----ALAAG --AALAAMGL PPRRFFDTTC SSPPYMMKTQ EYVVVVWWLV EMMGGDDEQQ VGPARALSSG LLAALAALAA PPGGRRDTTC SSPPYMMKTQ EYVVVVWWLA EVVGGDDEQQ ADDDFIVVVD DNPKSTTSSI HLYIIIDLHA CCSSACC--P PKPNNFFLLV VPPGGGLRSS PDDDFLVVVD DDPKSTTGGV YLYIIIDLHA CCSSACC--P PKPFFYYLLV VPPAAALRSS PDDDALVVID DKPGSTTGGI HMNTTTDFHA CCSSSSS--P PHAFFFFLLI IPPGGGLRSS PDDDALVVID DKPGSTTGGI HMNKKKDFHA CCSSASS--P PHAFFYYLLI IPPGGGLRSS PDDDGLVVVD DDPTSKKGGI HMNKKKDFHA CCSSASS--P PHAFFYYLLI IPPGGGIRSS PDDDAIVVVD DDPASRRAAI GMHAAADLHA CCSSCCC--P PHPHHYYLLV VPPGGGLRSS PDDDAMVVVD DDSQSTTGGV GMYTTTGLHA CCSSMCC--P PHPHHYYLLV VPPDDDIRSS PDDDALVVLD DDPDSTTAAI GMNAAADLHA CCSAACC--P PHPHHYYLLV VPPGGGIRSS PDDDYLTTVD DDPKSQQSSV HMYLLLDLHT CCSSC----- -DSTTKKLLL LPPGGGLMSS PDDDYLTTVD DDPKSHHSSV HMHLLLDLHT CCSSC----- -DSTTKKLLL LPPSSSIISS PDDDYLTTVD DDPKSQQCCV HMNLLLDLHA CCSSC----- -DSTTKKLLL LPPCCCLMSS PDDDYLTTVD DDPKSQQCCV HMHLLLDLHT CCSSC----- -DITTKKLLL LPPAAALISS PDDDYLTTVD DDPKSQQCCV HMNLLLDLHT CCSSC----- -DSTTKKLLL LPPSSSLISS PDDDYLTTVD DDPKSQQCCV E--------- ---------- ---------- ---------- PDDDYLTTVD DDPKSQQCCV HMNLLLDLHT CCSSC----- -DSTTKKLLL LPPSSSLISS PDDDYLTTVD DDPKSQQCCV HMNLLLDLHT CCSSC----- -DSTTKKLLL LPPSSSLISS PDDDYLTTVD DDPKSQQSSV HMYLLLDLHT CCSSC----- -DSTTKKLLL LPPSSSFISS PDDDYLTTVD DDPKSQQCCV HMNLLLDLHT CCSSC----- -DSTTKKLLL LPPSSSL--- PDDDYLTTVD DDPKSQQCCV HMNLLLDLHT CCSSC----- -DSTTKKLLL LPPSSSLISS LDDDYLTTVD DDPSSTTSSV HVHIIIDLHS CCSSC----- -DPSSFFLLL LPPSSSLLSS ---------- ---------- -MNTTTDLHT CCSSC----- -DASSKKLLL LPPCCCLISS PDDDYLTTVD DDPKSSSSSV HMNVVVDLHT CCSSC----- -DSSSKKLLL LPPCCCLISS PDDDYLTTVD DDPSSTTSSV HVYVVVDLHS CCSSC----- -DPSSFFLLA APPSSSLVSS PDDDYLTTVD DDPNSTTSSV HVYVVVDLHS CCSSC----- -DPSSFFLLV VPPGGGIVSS ---------- ---------- -MFVVVDLHS CCSSC----- -DASSYYLLL LPPSSSLISS PDDDYLTTVD DDPSSSSSSV HMFVVVDLHS CCSSC----- -DASSYYLLL LPPSSSLISS PDDDYLTTVD DDPNSTTSSV HVHVVVDLHA CCSSC----- -DPSSFFLLL LPPSSSLLSS PDDDAITTVD DNPESTTCCV SVHIIIDVHA CCSSC----- -KPTTHHLLV VPPCCCLNSS PDDDAITTVN NNPESTTCCI SVNIIIDVHA CCSSC----- -KPTTHHLLV VPPCCCLNSS ---------- ---------- ---------- ---------- -------MMP PRRKKKLSSS GDDDYLTTVD DDPASTTCCV HTSKKKNLHT CCSSCFFVVP PKEVVRRLLL LPPCCCLNSS GDDDYLTTVD DDPESTTCCI HTRKKKDLHA CCSSCYYVVD DKTVVRRLLL LPPSSSLNSS ITTTDRNNPR RVGQVLLGGV KVVLLLDELP RRILK----- -KRVVQQMMQ QLLSSSLDGG QDDDKLTTID DRPGSTTGGV NVG---NAHA ---------- -----FFFFT TGGGGGLDTT QDDDKLTTVD DNPKSQQGGV NVG---NAHD ---------- -----YYLLA AGGGGGLDTT SIIIYIKPPR RREPPPIIKV VVEPPEVVVV VSGGYSSTTH HCGPPPAAII AGNNNE---- SIIIYVKPKR RRRPPPVAKI IIEPPEAAAR RTGGYTTTTH HCGPPPAAII AGGGGP---- SIIIYIKPPT TTQAAAIHKI IIEPPDIIIK KTGGYSSTTH HCGPPPGGII TGGGGAGKKK SIIIYIKPPT TTKAAAIHKI IIEPPEVVVK KTGGYSSTTH HCGPPPGGII TGGGGGGKKK SIIIYVK-PL LLKAAAIHKI IIEPPEVVVK KTGGYSSTTH HCGPPPGGII TGGGGGGEEE SIIIYLKPPL LLKPPPLAKV VVEPPELLLR RTGGYSSTTH HCGPPPGGII AGNNNA---- SIIITLKPPT TTQPPPVVKV VVDPPNLLLR RTGGYAATTH HCGPPPGGII AGSSSP---- SIIIHVKPPR RREPPPIVKV VVEPPELLLR RTGGYSSTTH HCGPPPGGVV AGSSSP---- SIIIYVGSPR RRAPPPLHKV VVEAASIIIK KCNNVSSTTH HCLAAAGGEE NLGGGD---- SIIIYVGSPR RRAPPPLHKV VVEPPNIIIK KCNNLGGTTH HCLAAAGGEE SLGGGD---- SIIIYVGSPR RRAPPPLHKV VVEAAEIIIK KCGGLGGTTH HCLAAAGGEE SLGGGD---- SIIIYVGTPR RRAPPPLHKV VVEPPKIIIK KCNNLGGTTH HCLPPPGGEE SLGGGD---- SIIIYVGSPR RRAPPPLHKV VVEPPEIIIK KCEELAATTH HCLAAAGGEE SLGGGD---- ---------- ---------- ---PPKIIIK KCEELAATTH HCLAAAGGEE SLGGGD---- SIIIYVGSPR RRAPPPLHKV VVEPPKIIIK KCEELAATTH HCLAAAGGEE SLGGGD---- SIIIYVGSPR RRAPPPLHKV VVEPPKIIIK KCEELAATTH HCLAAAGGEE SLGGGD---- SIIIYVGTPR RRAPPPLHKV VVEAAKIIIK KCGGLGGTTH HCLPPPGGEE SLGGGD---- ---------- ---------- ---------- ---------- ---------- ---------- SIIIYVGSPR RRAPPPLHKV VVEPPKIIIK KCEELAATTH HCLAAAGGEE SLGGGD---- GVVVYVATPR RRTPPPLHKV VVESSEIIIN NIGGLGGTTH HCLAAAGGDD SLGGGD---- SIIIYVGTPR RRAPPPIHKT TTEPPYVVVK KCGGLAATTH HCLGGGGGEE SIGGGD---- SIIIYVGSPR RRAPPPIHKT TTEPPYVVVK KCGGLAATTH HCLGGGGGEE SLGGGD---- GIIIYIKTPR RRSPPPLHKV VVDPPAIIIK KTGGLAATTH HCLAAAGGEE SLGGGD---- GVVVYIKTPR RRAPPPLHKV VVEPPEIIIK KTGGLAATTH HCLAAAGGEE SIGGGD---- GIIIYIKEPR RRAPPPLYKY YYDPPKIIIK KTGGLAATTH HCLAAAGGEE SLGGGD---- GIIIYIKEPR RRAPPPLYKY YYDPPKIIIK KTGGLAATTH HCRTTTGGEE SLGGGD---- GVVVYVLKPR RRAPPPLHKV VVEAAEIIIK KTGGLGGTTH HCLAAAGGEE SLGGGD---- DIIIYIEN-R RRKIIILEHT TTEPPSLLLL LN--LSSTTH HCLAAAGGNN SLGGGE---- DIIIYIEN-R RREIIILQHT TTEPPSLLLL LN--LSSTTH HCLAAAGGNN SLGGGE---- GEEEGVGG-- ---------- ---------- ---------- ---------- ---------- DIIIFIGTPR RRAPPPLAKV VVEGG-VVVG GADDCTTTTH HCLPPPGGNN SMGGGD---- DIIIYLVTPR RRKPPPIVKT TTDGG-VVVS SHNNVTTTTH HCLAAAGGNN SMGGGD---- KLLLYTLYAW WWDKKKFYP- ------LLLF FLVVLAATTD DYQPPPTTAA DVNNNE---- NIIIFFHSPS SSNPPPLHKT TTDTT-VVVS SGGGVVVTTF FALPPPSSMM GSNNND---- SIIIFFHSPA AARPPPLSKT TTTDD-VVVS SGGGVVVTTY YALPPPRRMM GSNNNN---- G-GGGGGILL LMMMLDHSFE PEIIDRGGDQ QQQ------- ------LYDW WWWNNNNNL- GRGGGGGIFF FLLLLDHTFE PEVVYRGGPQ QQQ------- ------FYDW WWWNNNNNL- GTGGPPGIFF FIIIMDCTFD VEIIDRGGPQ QQQ------- ------KYDW WWWNNNNNL- GTGGPPGVFF FIIIMDCTFE VEIIDRGGPQ QQQ------- ------LYDW WWWNNNNNL- GTGGPPGIFF FIIILDCTFE IEMMDRGGEQ QQQ------- ------KYDW WWWNNNNNL- G-GGGGGIAA AMMMLDASFE PEVVERGGPQ QQQ------- ------FYDW WWWHHHHHL- G-GGGGGIFF FIIILDHNLE VEIIDRGGDQ QQQ------- ------LYDW WWWHHHHHL- G-GGGGGVFF FVVVMDHSFD PEVVERGGPQ QQQ------- ------LYDW WWWHHHHHL- QGGGGGSFVV VLLLLDGTFE VEKKPGGGAS SSS------- ------MYDW WWWQQQQQP- QGGGGGGFVV VLLLLDGTFE VEKKPGGGEA AAA------- ------MYDW WWWQQQQQP- KGGGGGGFVV VLLLLDGTFE VEQQPGGGAA AAA------- ------MYDW WWWQQQQQP- EGGGGGGFVV VLLLLDGTFE VEQQPGGGAA AAA------- ------LYDW WWWQQQQQP- KGGGGGGFVV VLLLLDGTFE VERRPGGGAA AAA------- ------SYDW WWWQQQQQP- KGGGGGGFVV VLLLLDGTFE VERRPGGGAA AAA------- ------LYDW WWWQQQQQP- KGGGGGGFVV VLLLLDGTFE VERRPGGGAA AAA------- ------LYDW WWWQQQQQP- KGGGGGGFVV VLLLLDGTFE VERRPGGGAA AAA------- ------LYDW WWWQQQQQP- KGGGGGGFVV VLLLLDGTFE VERRPGGGSA AAA------- ------MYDW WWWQQQQQP- ---------- ---------- ---------- ---------- ---------- ---------- KGGGDDGSLL LVVVLLPRLE C--------- ---------- ---------- ---------- EGAAGGNGFF FLLLLLDEFN VSNNRLFFPI III------- ------KRTL LLLEEEEENY YGGGGGGFVV VLLLLDGTFE VEAAEGEEAA AAA------- ------FYDW WWWQQQQQP- CGGGGGGFVV VLLLLDGTFE VEVVEGEESA AAA------- ------FYDW WWWQQQQQP- DGAAGGNGFF FLLLLLDDFN VEKKPGHHSP PPP------- ------FYDW WWWQQQQQP- DGAAGGNGFF FLLLLLDEFN VEKKPGHHSP PPP------- ------FYDW WWWQQQQQP- EGAAGGNGFF FLLLLLDDFN IEKKPGHHSP PPP------- ------FYDW WWWQQQQQP- EGAAGGNGLL LLLLLLDDFN IEKKPDIISP PPP------- ------YYHW WWWQQQQQP- EGAAGGNGFF FLLLLLDEFN VEKKPGHHSP PPP------- ------FYDW WWWQQQQQP- NGPPGGNFLL LLLLLDGTFE PPAADEKKTV VVV------- ------FYDW WWWQQQQQP- DGPPGGNFLL LLLLLDGTFE PPAADGKKVV VVV------- ------FYDW WWWQQQQQP- ---------- ---------- ---------- ---------- ---------- ---------- EGAAGG-DFF FVVVEFDNFE LSRRGDRRKA AAA------- ------CYDW WWWQQQQQP- EGAAGG-DFF FIIILFDDFN CTKKGDKKKA AAA------- ------CYDW WWWQQQQQP- LSPPLLNGII IQQQTSKENG LEAASQFFEE EEE------- ------LLSH HHHNNNNNG- DHGGTTALVV VEEEYNDGEY VMPPTADDDM MMMGAVAVGG DVADGGYYDR RRRLLLLLI- DHGGTTALVV VEEEYTNGEY VIPPTDGGDL LLLGAIKTGG -YADGGYYDR RRRLLLLLP- NEEEEELLSS SSEEAVVVVP -IEDGG---L LKEEKD--RR YGNNNRRIIH DRRRRIIIHH SGGGGGMMTS SSEETVVVVP -FEEGG---F FSEEKEGGAA YGNNNKKLLH DAARRLLLYY RDDDDDMMSS SSEEALLLLP -FENGG---I IVEELANNKK YGHHHRRLLH DRRRRVVVQQ RDDDDDMMTS SSEEALLLLP -FENGG---I IVEELSNNKK YGHHHRRLLH DRRRRVVVQQ RDDDDDMMSS SSEEGLLLLP -FENGG---I IVEELSNNKK YGHHHKKIIH KRRRRVVVQQ YDDDDDLLTS SSEEGTTTTP -VEDGG---L LVDDLGAARR YGRRRRRLLH DTTRRLLLQQ YDDDDDLLTS SSEEGTTTTP -VESGG---V VLDDLAGGKK YGHHHRRLLH DYYRRLLLQQ YDDDDDMMTS SSEEGTTTTP -IEGGG---L LDQQLNKKGG YGRRRRRLLH DRRRRLLLQQ HNNNNNMMST TTEEAAAAAP -FKDGGFFFN NPHHA-GGLL YGSSSRRIIF DQQHHIIIQQ HNNNNNMMST TTEEAAAAAP -FKDGGFFFN NPHHA-GGLL YGSSSHHIIH DQQHHIIIQQ HNNNNNMMST TTEEAAAAAP -FRDGGFFFN NPDDA-GGLL YGSSSHHLLH DQQHHIIIQQ HNNNNNMMST TTEEAAAAAP -LRDGGFFFN NPDDA-GGLL YGSSSHHLLY DQQRRVVVQQ HNNNNNMMST TTEEAAAAAP -LRDGGFFFN NPDDA-GGLL YGSSSHHLLY DQQHHVVVQQ HNNNNNMMST TTEEAAAAAP -LRDGGFFFN NPDDA-GGLL YGSSSHHLLY DQQHHVVVQQ HNNNNNMMST TTEEAAAAAP -LRDGGFFFN NPDDA-GGLL YGSSSHHLLY DQQHHVVVQQ HNNNNNMMST TTEEAAAAAP -LRDGGFFFN NPDDA-GGLL YGSSSHHLLY DQQHHVVVQQ HNNNNNMMST TTEEAAAAAP -VQNGGFFFN NPDDA-GGLL YGKKKHHLLH DQQHHVVVQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------A AAIIAHHHHS -RLTGGSSSR RDPPA-SSRR VAGGGIITT- ---------- WGGGGGFFSW WWIICCCCCS -YTTGGAAAE ELCCA-SSGG VHVVVIISSC NIIRRDDDEE HNNNNNMMST TTEEGAAAAP -FALGGFFFK KMEEA-GGMM YGHHHSSLLN DTTHHIIIQQ HNNNNNMMST TTEEGAAAAP -FALGGFFFK KMDDA-GGHH YGHHHSSLLN DTTHHVVVQQ HNNNNNMMST TTSSGAAAAP -FTKGGFFFD DLHHD-GGLL YGRRRHHLLT QAAGGRRRQQ HNNNNNMMST TTSSGAAAAP -FLQGGFFFN NLHHD-GGLL YGRRRHHLLH SPPGGKKKQQ HKKKKKMMST TTSSGAAAAP -FSKGGFFFD DLHHD-GGLL YGSSSHHLLH SPPGGKKKQQ HKKKKKMMST TTSSGAAAAP -FSKGGFFFN NLHHD-GGLL YGSSSHHLLH SPPGGKKKQQ HKKKKKMMSS SSSSGAAAAP -FRTGGFFFD DLHHD-GGLL YGRRRHHLLH DPPGGKKKQQ RNNNNNMMST TTEEGSSSSP -IKKGGFFFN NPHHE-GGLL YGNNNSSVVH EDDKKLLLQQ RNNNNNMMST TTEEGSSSSP -IKKGGFFFN NPHHE-GGLL YGNNNSSVVH EDDKKLLLQQ --------SI IILLGGGGGP -VCRDDEEEE ELCCE-PPLL VIKKKCCKKR ---------- FNNNNNMMAS SSEEGAAAAP -FRRGGYYYH HPDDDRTTQQ YGCCCRRLLN RQQRRFFFQQ FDDDDDMMSS SSEEGAAAAP -WRRGGWWWK KNDDDMSSQQ YGCCCRRLLN KSSQQYYYQQ REEEEESSSD DDRRDEEEEP -AFESSSSSE ESLLTGPPLL KPQQQHHVVA L--------- KNNNNNMMTS SSSSTGGGGW NMDFGGQQQM MLDDAMKKRR FGNNNTTIIV DHHRRKKKKK KNNNNNLLTS SSSSTGGGGW NMDFGGKKKM MLDDAMKKHH FGNNNTTVVV DHHKKKKKKK TTTLEEEEMA A------EEL LLPLDPKLLL LMFIINVSDD DLSIIIWLFF FFYY---EED DDDLQQEEMV V------EEV VVPLDPKLLL LMFVVNVNDD DLSIIIWLFF FFYY---EED DDDLAAQQMA A------EEV VVPADPREEE EYFVVGVDNN NLSIIIWTWW WWRR---EEG DDDLAANNMA A------EEV VVPADPREEE EYFVVGVDNN NLSIIIWTWW WWRR---EEG DDDLAANNMA A------EEI IIPADPKDDD DYFCCGVDNN NLAIIIFTWW WWQQKKKDDD DDDFDDEELV V------EEL LLPADPKAAA AYFVVNVSDD DLSIIIWTYY YYRR---DDK DDDLAAEEMA A------EEL LLPADPKAAA AYFMMNVSDD DLSIIIWLYY YYRR---DDN DDDVEEEEMV V------EEL LLPADPRTTT TYFVVGVSDD DLSVVVWLHH HHRR---QQN QQQM----LI I------EEI IIFLDPATTT TQFVVGASII IQYKKKNEGG GG-------- QQQM----LI I------EEI IIFLDPATTT TQFVVGASII IQYKKKNEGG GG-------- TTTL----LI I------EEI IIFLNPAAAA AQFVVGASII IQYKKKNQGG GG-------- PPPL----LI I------EEI IIFLNPAAAA AQFVVGASII IQFKKKNEGG GG-------- SSSL----LI I------EEI IIFLNPAAAA AQFVVGASII IQYKKKNEGG GG-------- SSSL----LI I------EEI IIFLNPAAAA AQFVVGASII IQYKKKNEGG GG-------- SSSL----LI I------EEI IIFLNPAAAA AQFVVGASII IQYKKKNEGG GG-------- SSSL----LI I------EEI IIFLNPAAAA AQFVVGASII IQYKKKNEGG GG-------- LLLM----HI I------EEI IIFLDPASSS SQFVVGASII IQYKKKNEGG GG-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPPL----AG GNNNPPICCL LLSIWKINNN NQYDDVESGG GRSDDDPDYY YY-------- DDDLEE--LI I------EEI IIFLDPAAAA AQLVVGASVV VFYKKKEKGG GG-------- DDDLKK--LI I------EEI IIFLNPADDD DQLVVGASII IFYKKKEKGG GG-------- DDDLNN--LL L------EEI IIFLDPKDDD DTFVVGASMM MIFKKKTQGG GG-------- DDDLDD--LL L------EEI IIFLDPKDDD DTFVVGATMM MIFKKKTQGG GG-------- DDDLEE--LL L------EEI IIFLDPKDDD DTYVVGASMM MIFKKKNSDD DD-------- DDDLPP--LL L------EEI IIFLDPKDDD DTFVVGASMM MIFKKKNSEE EE-------- DDDLSS--LL L------EEV VVFLDPKDDD DTYVVGATMM MVFKKKTAGG GG-------- DDDLQQPPAL L------EEV VVFLEPSEEE EHFVVGAGII IFHPPPVENN NNSS------ DDDLMMPPAL L------EEV VVFLEPSEEE EHFVVGAGII IFHPPPDENN NNPP------ ---------- ---------- ---------- ---------- ---------- ---------- DDDLDD--LT T------EEI IIFLNPENNN NQYVVGAXXX XXX------- ---------- DDDLSS--IT T------EEI IIFLNPKAAA AEFVVGANVV VFKKKKKSSS SSDD------ ---------- ---------- ---------- ---------- ---------- ---------- NNNVGGAA-- -------EEI IIFPGSANNN NYFSSTATLL LWYEEEDDGG GG-------- DDDVGGAA-- -------EEI IICAGEHNNN NYFTTSATLL LWYEEEDGGG GG-------- GKWWNNAVVI IILLLPEILL PPKVPPVTTI DIILDDKLYL LLLWIGGRQY DDNFFFFKKK GKWWQQAVVI IIFFFPPVLL DDKVPPVTTI DIILDDRLYV VLLWLGGRQY DDNHHHHQQQ GKFFHHVTTA AAAAAPPLLL GGGVPPVTTI DLLLDDRLYV VCCWTGGRQY DDDHHHHNNN GKFFHHATTA AAAAAPPLLL GGGVPPVTTI DLLMDDRLYV VCCWTGGRQY DDDRRRRKKK GTFFEEATTI IIAAAPDLLL GGGCPPVTTI DLLLDDKLYV VCCWLGGHQY DDDMMMMNNN DKWWAAVVVI IIAAAPPVLL GGKVPPVTTI DLLMDDRLYV VCCWTGGLQY DDDFFFFEEE GSWWHHLVVI IIAAAPPILL PPKVPPVTTI NLLVDDRLYV VCCWTGGHQY DDDFFFFNNN GSWWGGIVVI IIAAAPPLLL DDGVPPVTTI NLLLDDRLYV VCCWTGGRQY DDDFFFFNNN ---------T TTIIIKVKGG MMPMPGITTI LLLLDDRLYF FNNWHGGRQY DDNQQQQKKK ---------T TTIIIKVKGG MMPMPGITTI LLLLDDRLYF FNNWHGGRQY DDNKKKKKKK ---------T TTIIIKVKGG MMPMPGITTI LLLLDDRLYF FNNWHGGRQY DDDQQQQRRR ---------T TTIIIKVKGG MMPMPGITTI LLLLDDHLYF FNNWHGGRQY DDDQQQQRRR ---------T TTIIIKVKGG LLPMPGITTI LLLLDDRLYF FNNWHGGRQY DDDQQQQRRR ---------T TTIIIKVKGG LLPMPGITTI LLLLDDRLYF FNNWHGGRQY DDDQQQQRRR ---------T TTIIIKVKGG LLPMPGITT- ---------- ---------- ---------- ---------T TTIIIKVKGG LLPMPGITTI LLLLDDRLYF FNNWHGGRQY DDDQQQQRRR ---------T TTIIIKVKGG MMPMPGITTI LLLLDDRLYF FNNWHGGRQY DDDKKKKRRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A AALLLVVAKK GGVLSNFPPA WIIFSDLIIF FSS------- ---------- ---------K KKIIIKVEGG AAPMPGITTI LIILDDRLYF FNNWHGGRQY DDDRRRRNNN ---------K KKIIIKVEGG PPPMPGITTI LIILDDRLYF FNNWHGGRQY DDDRRRRNNN ---------S SSIIIKVQNN IIPMPGITTF LIILDDRLYF FNNWHGGRQY NNDKKKKNNN ---------S SSIIIKVQNN FFPMPGITTF LIILDDRLYF FNNWHGGRQY NNDKKKKNNN ---------T TTIIIKVENN IIPMPGITTF LIILDDRLYF FNNWHGGRQY NNDKKKKNNN ---------T TTIIIKVENN IIPMPGITTF LIILDDRIYF FNNWHGGRQY NNDKKKKNNN ---------S SSIIIKVRNN IIPMPGITTF VIILDDRLYL LNNWHGGRQY NNDAAAAKKK ---------T TTAAAKVSGG AAPMPAITTI LIIMDDRLYV VCCWHGGRQY DDDLLLLKKK ---------V VVAAAKVENN AAPMPAITTI LIIMDDRLYV VCCWHGGRQY DDDKKKKNNN ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----QGENN EEEMGGMTTI LIILDDRLYF FNNWHGGRQY DDDAAAANNN -------FFE EEIIIDTGSS VVEMGGISSI IIILDDRLYV VCCWHGGRQY DDDEEEENNN ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----AVADD GGPDIPPVVI SIIADDQLWI ISSFDGGRLF DDDHHHHKKK ---------- -----AVADD GGPKVPPVVI SIINDDSLWV VTTFDGGRLF DDDHHHHHHH LGKVLIRRRA P--------- ---------A AGKLTGAQQM LEEIISSSRD DDDGVTTTNW LGRVILRRRE P--------- ---------S SGEATGAQQM ISSVVSSSRD DDDGVTTTNW LGSVIIRRRA P--------- ---------N NGTFAGGQQM VEEIISSSRD DDDGVTTTNW LGSVIIRRRT P--------- ---------N NGAFAAGQQM VEEIISSSRD DDDGVTTTNW LGKVIIKKKT P--------- ---------N NGTFGYGQQM VEEIISSSRD DDDGVTTTNW LGKVIIRRRA PGG------- ---------K KNALNGGQQM VEEIISSSRD DDDGVTTTNV LGKVIIRRRA P--------- ---------T TSELNGGQQM VEEIISSSRD DDDGVTTTNW HGSVLIKKKA P--------- ---------A ASPLNGGQQM VEEVVSSSRD DDDGVSSSNW LGQILSRRRG VQQVLE--DQ ETTQPPEEPK KGRIPGGQQM IQQLLSSSLD DDDGLTTTTW LGQILSKKKG VQQVLE--DQ ETTQPPEEPK KGRVPGGQQM IQQLLSSSLD DDDGLTTTTW LGQLLSKKKG VQQVLE--DQ EKKQPPEEPK KGKVPGGQQM IQQLLSSSLD DDDGLTTTTW LGQLLSKKKD VQQVLD--DQ EDDQPPEEPK KGQVAGGQQM IQQLLSSSLD DDDGLTTTTW LGQLLSKKKG VQQVLE--DQ EKKQPPEEPK KGRVAGGQQM IQQLLSSSLD DDDGLTTTTW L--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGQLLSKKKG VQQVLE--DE EKKQPPEEPK KGRVAGGQQM IQQLLSSSLD DDDGLTTTTW LGQILSKKKG VQQVLE--DQ EKKQPPEEPK KGRVPGGQQM IQQLLSSSLD DDDGITTTTW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGQILSRRRG VTTVLE--DK DEEQPPDDPK KGKVPGGQQM IQQLLSSSLD DDDGLTTTNW LGQILSRRRG VTTVLE--DK EEEQPPDDPK KGIIPGGQQM IQQLLSSSLD DDDGITTTSW LGQLVLKKKG VAAAIG--ED GTTQSSDDVQ QGKLRGGQQM IQQLLTTTLD DDDGLTTTNW LGQVALKKKG VVVAVK--DD GTTQSSDDVQ QGKLRGGQQM IQQLLSSSLD DDDGLTTTNW LGQIVLKKKG VKKAVG--ED GSSQFFDDVK KGSLRGGQQM IQQLLSSSLD DDDGLTTTNW LGQIVLKKKG VKKAVG--ED GTTQFFEEVK KGSLRGGQQM IQQLLSSSLD DDDGLTTTNW LGQVALKKKG VVVYVT--ED DEEQYYSSVK KGRLRGGQQM IQQLLSSSLD DDDGITTTNW LSQVISTTTE VKKVLE--GE K--PIIEEAK KGKIEGGQQM LQQLLSSSLD DDDGLTTTTW LSQVISSSSE VKKVLE--ED H--EIIPPAK KGQIEGGQQM LQQLLSSSLD DDDGLSSSTW ---------- ---------- ---------- -----GGAAK IQQLLSSSVD DDDGLTTTNW LGQVLARRRD RRRVLN--DP EKKAPPEEPK KGRLLGGQQM LQQLLSSSLD DDDGLSSSSW LGQLLASSSD NVVIVKEEDK EKKRPPPPAK KGRLEGGQQM LQQLLSSSLD DDDGLSSSSW ---------- ---------- ---------- ---------- ---------- ---------- QYEKIQ---- ---------- ---------- ---------M VSSQQSSSWD DDDGVSSSSW QYEKIQ---- ---------- ---------- ---------M VSSSSSSSWD DDDGLTTTSW WNQFFEEKKG MMKKLNNNN- -----PPSGI DKKKFE---- AARHRRLSGD SDDDDCYP-- WNQFF--RRG MMKKVNNNN- -----PPEGL EKKKFR---- AARHRRLWGD TDDDDCYP-- WDQFFDDPPA QQLLAHHHG- -----PPDGL ADDDYDGG-- YYRHRRLEGD TDDDDCYPVV WDQFFDDPPG EEMMANNNG- -----GGNGL DKKKYDGG-- YYRHRRLEGD TDDDDCYPVV WEQFFGGGGA MMMMANNNG- -----EENGL DKKKFAGG-- YYRHRRLEGD TDDDDCYPVV VPQFFEEDDG MMKKLDDDG- -----PPNGF DPPPFKGG-- HHRHRRLQGD SDDDDCYP-- WEQFFDDKKG MMKKVDDDN- -----PPDGF DPPPFE---- QQRHRRLQGD SDDDDCFP-- WEQFFVVRRG IIKKAEEED- -----PPGGL DPPPFDGG-- LLRHRRLEGD SDDDDCYP-- WKQFFPPIIR GGVVMLLLVD DDVVTVVNGL NPPPFKEELP AALHRRYPGD SDDDDI---- WKQFFPPIIR GGVVMLLLID DDVVTAANGL NPPPFKEELP AALHRRYPGD SDDDDI---- WKQFFPPIIR GGVVMLLLID DDVVTVVKGL NPPPFKEELP AALHRRYPGD SDDDDL---- WKQFFPPIIR GGVVMLLLID DDVVTVVKGL NPPPFKEELP AALHRRYPGD SDDDDL---- WKQFFPPIIR GGVVMLLLVD DDVVTVVKGL NPPPFKEELP AALHRRYPGD SDDDDI---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WKQFFPPIIR GGVVMLLLVD DDVVTVVKGL NPPPFKEELP AALHRRYPGD SDDDDI---- WKQFFPPIIR GGVVMLLLID DDVVTVVKGL NPPPFKEELP AALHRRYPGD SDDDDL---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WKQFFPPIIK GGVVMLLLID DDVVTEEKGL NPPPFKEEGP VVLHRRYPGD SDDDDV---- WKQFFPPLLK GGVVMLLLID DDVVTKKKGL NPPPFKEEDP VVLHRRYPGD SDDDDI---- WKQFFPPVVE GGHHILLLID DDVVTEEKGI NPPPFAEEDP AALHRRYPGD SDDDDI---- WKQFFPPVVE GGHHILLLID DDVVTEENGI NPPPFAEEDP SSLHRRYPGD SDDDDI---- WRQFFPPMMD GGHHIIIIID DDVVTEEKGI NPPPFDEEEP AALHRRYPGD SDDDDI---- WVSFFPPMME GGHHIIIIID DDGGTEEKGI NPPPFDEEDP SSLHRRYPGD SDDDDI---- WEQFFQQVVK GGHHMLLLID DDVVTEEKGI NPPPFAEEEP SSLHRRYPGD SDDDDI---- WDQFFPPVVK GGTTMVVVVN NNIIPEESGI NRRRFKIIGP YYLHRRYPGD SDDDDI---- WDQFFPPVVR GGTTMLLLID DDVVPIITGI NKKKFKVVGP YYLHRRYPGD SDDDDI---- WKQFFPPVVK GGVVMLLLID DDVVTEEKGV NKKKFKEENP CCLHRRFPGD SDDDDA---- WKQFFPPVVA GGTTIVVVLD DDIIVEENGL NEEEFGEEYP GGLHRR---- ---------- WKQFFPPVVS GGHHIVVVID DDVVTVVNGL NEEEFNEEYP SSLHRRYPGD SDDDDLANAA ---------- ---------- ---------- ---------- ---------- ---------- W--------K GGDDDAAAYL LLKKYNNWDL VEEEFELLL- --RHRRFGSA SSSSS----- W--------K GGDDDEEEFL LLKKYYYWDL KEEEFAEEL- --RHRRFGRA AGGGGGDGRR ------- ------- VK----- V------ V------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- A------ ------- ------- RLQQRRE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158SKKKQPSETT TVVPTTGTTA AAADGAMMQQ SSLLLLPPRT TTAALSLTTP PSSVVVVVRR gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IYQQQEWWWT SSSQQVAASS RSSESGRRTR SGVIVAKQVV SSSQQAQQWW AAHWLPPGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----EERRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MGLKKEEE ---------- ---------- ---------- ---------- --------LL LLKNSGGCCC ---------- ---------- ---------- ---------- ---------- ---------- -MAAAGAAAP LPPNNNTTTT HPPNPAPPSP PRPTRPYRII VVVPPPPPCC PPPHAHHSSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MRRRRR ---------- ---------- ---------- ---------- ---------- ----MRRFFF ---------- ------MMAI IFFKDPTTYS PKMMKDDAYL TTGINRDFIA AVNNSSTTTS ---------- ---------M MLLKDPTTYT PRDMRDDAYL TTGVNADFLA AVDDSSTTTG ---------- ---------- -MMRDPTTHS PELMQEEAYL FFS--RDALA AVKKSSTTTG ---------- ---------- -MMRDPTTHS PKLMENNAYL FFS--KDALA AVKKSSTTTG ---------- ---------- -LLRDPTTYS AKLMEKKAFL AAS--KDGLA AVDDSSKKKG ---------- ---------M MWWKDPSSYS PRLAKTTAYF RRK--QDAIA AVDDSSRRRA ---------- ---------M MWWRDPTTYS PRMVKKKAYL AANG-KDAMC CVDDSSTTTG ---------- ---------M MWWRDPTTYS PKMMQRRGYL RRE--RDALG GLDDSSTTTA ---------- -----ATTKC C---GPGGPP LEAK-EEVYI TTGTEADYLA AVDDSSQQQS ---------- ---------- ---------- ---M-EEVYI TTGIEADYLA AVDDSSHHHS KHVIRGGGLL LLG-ASTTQC C---GPGGPP LEAK-EEVYI TTGIEADYLA AIDDSSQQQC ---------- ---------- ---------- ---K-EEIYI TTGIEADYLA AVDDSSQQQC ---------- -----ATTKC C---GPGGSP LEAK-EEVYI TTGTEADYLA AVDDSSQQQC AETQQPPPMM MRIASATTKC C---GPGGSP LEAK-EEVYI TTGTEADYLA AVDDSSQQQC ---------- -----ATTKC C---GPGGSP LEAK------ ---TEADYLA AVDDSSQQQC ---------- -----ATTKC C---GPGGSP LEAK-EEVYI TTGTEADYLA AVDDSSQQQC EPAPSGGGQQ QLQEDATTKC C---GPGGPP QEAK-EEVYI TTGTEADYLA AVDDSSQQQS LGTTTYYYCC CTVFTPTTKC C---GPGGSP LEAK-EEVYI TTGTEADYLA AVDDSSQQQC ---------- -----ATTKC C---GPGGSP LEAK-EEVYI TTGTEADYLA AVDDSSQQQC LVIEAVVVEE ETAAAGKKTC CTTAGPGGAP LEAEKKKVYV TTGINKDYLA ALDDSSTTTS ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MAAKC C---GPGGKP LDAK-EEVYI TTGINKDYLA AVDDSSSSSS ---ADHHHGG GVNEKS--VN NCCKGPGGAP IESS-SSIYV TTGIEKDYLA AVDDSSTTTS ---GQHHHAA AVSEKNNNQQ QCCKGPGGAP LEAS-TTIYV TTGIEKDYLA ALDDSSTTTS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R RQQVGPGGAP LAAS-KKIYV TTGIDKDYLA AVDDSSSSSS ---------- -MAAAGAAAC CGGAGPGGAP LEAEKKKLYV TTGINKDYLG GVDDSSTTTS ---------- --SPNGLLKC C---GPGGAP ADAK-EELFP NNAADGDAIF FVNNSSTTTC ---------- --P--PLLKC C---GPGGAP ADAK-EELFP HHARDGDAIF FVNNSSTTTC ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMSE ECCKGPGGAP LDARNKKLYV LLDEEHDYLA AVDDSSTTTC ---------- ---------- ---------- ---RSKKLYV LLDEPHDYLS SVDDSSTTTC ---------- ---------- ----MPGGI- -DIISFFYFL IIRQYDTDRK KMVVVVLLLG EF---AAALL LAG-AAMMGL LRRAADEECS PYMKIEEVYL GGMGDEDKLV VLRRSSTTTG IVSHRAAALL LVGLAALLAA AGGVADEECS PYMKIDDVYL GGVGDEDKLV VANNSSQQQG KIIIVHVEEE YNNNNDDEHG GNNACSSSAA LLLLC-PPKP NEERLVVRRS IYIIIITTKK KVVVIYLDDD YGGGGDDEHG GNNACSSSAA YYYYC-PPKP FEERLVVRRS IYIIIVTTKK KIIIVHVTTT NGGGGDDEHG GNNACSSSSS LLLLS-PPHA FEERLIIRRS IYVVVITTKK QIIIVHVTTT NGGGGDDEHG GNNACSSSAA LLLLS-PPHA FEERLIIRRS IYIIIITTKK QIIIVHLIII NGGGGDDEHG GNNACSSSAA LLLLS-PPHA FEERLIIRRS IYIIIVVVKK SIIIVGVAAA HGGGGDDEHG GNNACSSSCC LLLLC-PPHP HEERLVVRRS IYIIILTTKK QVVVVGTDDD YGGGGGGEHG GNNACSSSMM LLLLC-PPHP HEERLVVRRS ITIIILTTKK QIIIVGVEEE NAAAADDEHG GNNACSAAAA LLLLC-PPHP HEERLVVRRS IHIIIVTTKK QVVVIHLPPP YKKKKDDEHG GNNTCSSSCC --------DS TSSRLLLMMS IYVVVVVVGG QVVVIHLPPP HKKKKDDEHG GNNTCSSSCC --------DS TSSRLLLIIS IYVVVVVVGG QVVVIHLPPP NRRRRDDEHG GNNACSSSCC --------DS TSSRLLLMMS IYVVVVVVGG QVVVIHLPPP HKKKKDDEHG GNNTCSSSCC --------DI TAARLLLIIS IYVVVVVVGG QVVVIHLPPP NKKKKDDEHG GNNTCSSSCC --------DS TSSRLLLIIS IYVVVVVVGG QVVVIE---- ---------- ---------- ---------- ---------- ---------- QVVVIHLPPP NKKKKDDEHG GNNTCSSSCC --------DS TSSRLLLIIS IYVVVVVVGG QVVVIHLPPP NKKKKDDEHG GNNTCSSSCC --------DS TSSRLLLIIS IYVVVVVVGG QVVVIHLPPP YKKKKDDEHG GNNTCSSSCC --------DS TSSRLLLIIS IYVVVVVVGG QVVVIHLPPP NKKKKDDEHG GNNTCSSSCC --------DS TSSRLLL--- ---------- QVVVIHLPPP NKKKKDDEHG GNNTCSSSCC --------DS TSSRLLLIIS IYVVVVVVGG QVVVIHLPPP HGGGGDDKHG GNNSCSSSCC --------DP SKKRLLLLLS VYVVVVTTAA ---------- NNNNNDDEHG GNNTCSSSCC --------DA SVVRLLLIIS IYVVVVVVGG QVVVIHLPPP NNNNNDDEHG GNNTCSSSCC --------DS SVVRLLLIIS IYVVVVVVGG KVVVIHLPPP YGGGGDDEHG GNNSCSSSCC --------DP SEERLAAVVS IYVVVITTKK KVVVIHLPPP YGGGGDDEHG GNNSCSSSCC --------DP SQQRLVVVVS VYVVVITTKK ---------- FGGGGDDEHG GNNSCSSSCC --------DA SDDRLLLIIS IYAAAITTKK SVVVIHLPPP FGGGGDDEHG GNNSCSSSCC --------DA SDDRLLLIIS IYAAAITTKK QVVVIHLPPP HGGGGDDEHG GNNACSSSCC --------DP SSSRLLLLLS VYVVVVTTLL QVVVISVDDD HGGGGDDEHG GNNACSSSCC --------KP TKKRLVVNNS IYIIIIVVEE QIIIISVDDD NGGGGDDEHG GNNACSSSCC --------KP TKKRLVVNNS IYVVVIVVEE ---------- ---------- ---------- ---------- ----MPPSSS EGKKKVVVGG QVVVIHTYYY SHHHHNNEHG GNNTCSSSCC HHHHFVPPKE VTTRLLLNNS IFVVVITTGG QIIIVHTFFF RGGGGDDEHG GNNACSSSCC YYYYYVDDKT VKKRLLLNNS IYIIILVVVV SVVVLKGPPP VEEEEDDKLQ QTTPRILLKK --------KR VGGGMQQDDG LYVVVTSSLL QVVVINVSSS GRRRRNNEHG GSSA------ ---------- -DDRFTTDDT IFIIIFVVHH KVVVVNLSSS GRRRRNNEHD DTTD------ ---------- -DDRLAADDT IFVVVFVVHH NREEEIIKKI EPEEEEEEVK KKKVSRRRLL HHVHHCPAAY YYYSALGGNN N--EEGPPPG DRRRRAAKKV EPEEEVVVAV GGGRTKKKYY HHVHHCPAAY YYYSALGGGG G--DDGPPPG HTQQQHHKKI EPDDDEEEIL AAAKSRRRPP HHVHHCPGGY YYYSTLGGGG GGKDDGAAAG DTKKKHHKKI EPEEEEEEVF KKKKSRRRPP HHIHHCPGGY YYYSTLGGGG GGKDDGPPPG ELKKKHHKKI EPEEEEEEVF AAAKSRRRPP HHIHHCPGGY YYYSTLGGGG GGEDDGPPPG DLKKKAAKKI EPEEETTTLA EEERSRRRPP HHVHHCPGGY YYYTALGGNN N--EEGPPPG DTQQQVVKKI DPNNNEEELA EEERARRRPP HHVHHCPGGY YYYSALGGSS S--EEGPPPG DREEEVVKKI EPEEEEEELH RRRRSRRRPP HHIHHCPGGY YYYSALGGSS S--EEGPPPG ERAAAHHKKI EASSSEEEIQ AAAKSNNNTT HHSHHCAGGV VVVVNTLLGG G--LLGKKKS ERAAAHHKKI EPNNNEEEIH AAAKGNNNLL HHSHHCAGGV VVVISSLLGG G--PPGKKKG DRAAAHHKKI EAEEEDDDIH AAAKGYYYVV HHSHHCAGGV VVVISTLLGG G--SSGKKKG ERAAAHHKKI EPKKKDDDIH TTTKGFFFFF HHSHHCPGGV VVVVSTLLGG G--PPGKKKG ERAAAHHKKI EPEEEDDDIH AAAKAFFFLL HHSHHCAGGV VVVISSLLGG G--VVGKKKG ---------- -PKKKDDDIH AAAKAFFFLL HHSHHCAGGV VVVISSLLGG G--VVGKKKG ERAAAHHKKI EPKKKDDDIH AAAKAFFFLL HHSHHCAGGV VVVISSLLGG G--VVGKKKG ERAAAHHKKI EPKKKDDDIH AAAKAFFFLL HHSHHCAGGV VVVISSLLGG G--VVGKKKG ERAAAHHKKI EAKKKDDDIH EEEKGTTTPP HHSHHCPGGV VVVISTLLGG G--PPGKKKG ---------- ---------- ---------- ---------- ---------- ---------- ERAAAHHKKI EPKKKDDDIH AAAKAFFFLL HHSHHCAGGV VVVISSLLGG G--VVGKKKG DRTTTHHKKV ESEEEDDDIA EEENGFFFPP HHSHHCAGGI IIIISCLLGG G--KKAAAAN DRAAAHHKKV EPYYYEEEVF WWWKANNNLL HHSHHCGGGI IIIISSIIGG G--PPGKKKG DRAAAHHKKV EPYYYEEEVF WWWKANNNPP HHSHHCGGGI IIIISSLLGG G--PPGKKKG NRSSSHHKKV DPAAADDDII QQQKAYYYPP HHSHHCAGGL LLLISCLLGG G--KKAEEEN NRAAAHHKKV EPEEEDDDIS TTTKAYYYPP HHSHHCAGGI IIIISCIIGG G--KKAEEEN NRAAAYYKKV DPKKKEEEIA EEEKAYYYPP HHAHHCAGGI IIIVSCLLGG G--EEAKKKN NRAAAYYKKV DPKKKEEEIA DDDKAFFFPP HHAHHCTGGI IIIVSCLLGG G--EEAKKKN DRAAAHHKKV EAEEEDDDIA EEEKGFFFPP HHSHHCAGGI IIIISCLLGG G--KKAAAAN ERKKKEEHHI EPSSSKKKLH SSSLSFFFPP HHSHHCAGGI IIIISTLLGG G--AAPSSSN EREEEQQHHI EPSSSKKKLH AAALSFFFPP HHSHHCAGGI IIIISTLLGG G--AAPSSSN ---------- ---------- ---------- ---------- ---------- ---------- DRAAAAAKKI EG---DDDVL KKKGTAAAPP HHTHHCPGGI IIIISIMMGG G--AAAKKK- DRKKKVVKKI DG---DDDVL KKKSTAAAPP HHTHHCAGGI IIIISVMMGG G--AAAKKK- SWDDDYYPP- -----DDDLI KKKFAIIISS HHADDYPTTL LLLQDGVVNN N--SSPVVVN DSNNNHHKKI DT---FFFVK DDDSVGGGPP HHFFFAPSSM MMMTGLSSNN N--DDGRRRA DARRRSSKKI TD---FFFVE KKKSVGGGPP HHLYYAPRRL LLLTGLSSNN N--KKGRRRA IIILMMLLHS SFEEPLKKEE IDDDRGDY-- --------AA YDDDDFFFFN --PNVLVSSS IIIFLLLLHT TFEEPIRREE VYYYRGPY-- --------AA YDDDDFFFFN --PSVMITSS IIIFIIMMCT TFDDVLRREE IDDDRGPD-- --------HH YDDDDFFFFN --PRYMVSSS VVVFIIMMCT TFEEVLRREE IDDDRGPT-- --------HH YDDDDFFFFN --PRYMVTSS IIIFIILLCT TFEEILRREE MDDDRGET-- --------HH YDDDDFFFFN --PRYMVSSS IIIAMMLLAS SFEEPLRREE VEEERGPY-- --------AA YDDDDGGGGH --GYTLVTSS IIIFIILLHN NLEEVLRREE IDDDRGDY-- --------HH YDDDDFFFFH --GYTLLTSS VVVFVVMMHS SFDDPLRREE VEEERGPQ-- --------AA YDDDDFFFFH --GYTMVTSS FFFVLLLLGT TFEEVKTTEE KPPPGGAP-- --------GG YDDDDFFFFQ --RHVMVSTT FFFVLLLLGT TFEEVKTTEE KPPPGGEP-- --------GG YDDDDFFFFQ --RHIMVSTT FFFVLLLLGT TFEEVKTTEE QPPPGGAP-- --------GG YDDDDFFFFQ --RHVMISTT FFFVLLLLGT TFEEVKTTEE QPPPGGAP-- --------GG YDDDDFFFFQ --RHVMISTT FFFVLLLLGT TFEEVKTTEE RPPPGGAP-- --------GG YDDDDFFFFQ --RHVMISTT FFFVLLLLGT TFEEVKTTEE RPPPGGAP-- --------GG YDDDDFFFFQ --RHVMISTT FFFVLLLLGT TFEEVKTTEE RPPPGGAP-- --------GG YDDDDFFFFQ --RHVMISTT FFFVLLLLGT TFEEVKTTEE RPPPGGAP-- --------GG YDDDDFFFFQ --RHVMISTT FFFVLLLLGT TFEEVKTTEE RPPPGGSP-- --------GG YDDDDFFFFQ --RHVMISTT ---------- ---------- ---------- ---------- ---------- ---------- SSSLVVLLPR RLEECS---- ---------- ---------- ---------- --------AA GGGFLLLLDE EFNNVKRRSS NRRRLFPS-- --------EE RTTTTHHHHE YYAWLFWSWW FFFVLLLLGT TFEEVKNNEE AEEEGEAP-- --------GG YDDDDFFFFQ --RHVMISTT FFFVLLLLGT TFEEVKNNEE VEEEGESQ-- --------GG YDDDDFFFFQ --RHVMISTT GGGFLLLLDD DFNNVKRREE KPPPGHSL-- --------GG YDDDDFFFFQ --RHTMISTT GGGFLLLLDE EFNNVKRREE KPPPGHSL-- --------GG YDDDDFFFFQ --RHTMISTT GGGFLLLLDD DFNNIKRREE KPPPGHSL-- --------GG YDDDDFFFFQ --RHTMISTT GGGLLLLLDD DFNNIKRREE KPPPDISL-- --------GG YHHHHFFFFQ --RHTMISTT GGGFLLLLDE EFNNVKRREE KPPPGHSL-- --------GG YDDDDYYYYQ --RHTMISSS FFFLLLLLGT TFEEPKTTPP ADDDEKTP-- --------NN YDDDDFFFFQ --RRVMISTT FFFLLLLLGT TFEEPKTTPP ADDDGKVP-- --------NN YDDDDFFFFQ --RRIMISTT ---------- ---------- ---------- ---------- ---------- -------SII DDDFVVEEDN NFEELVTTSS RGGGDRKL-- --------GG YDDDDYYYYQ --HFVMVASS DDDFIILLDD DFNNCITTTT KGGGDKKL-- --------GG YDDDDFFFFQ --YFVMVSSS GGGIQQTTKE ENGGLSKKEE ASSSQFEI-- --------QQ LSSSSNNNNN ---RKSESDD LLLVEEYYDG GEYYVAYYMM PTTTADDQAA VGGVVAAGGG YDDDDIIIIL --RKVMLTSS LLLVEEYYNG GEYYVAHHII PTTTDGDRAK TGGYYAAGDD YDDDDVVVVL --RKLLVTSS EEVVNTI-LL LLEEHKDGNN NIIHHWWWDL RKKRRRIHSL GGEEENNNRR RMAAAAL--- EEVVRCF-FF FFEECKEGNN NLLHHWWWDL AKRHHHLYAL GGQQQHHHRR RMVVVVL--- EELLPQF-II IIEEDLAGHH HLLHHWWWDL RARNNNVQTL GGAAAHHHQQ QMAAAAL--- EELLPQF-II IIEEDLSGHH HLLHHWWWDL RARNNNVQTL GGAAAHHHQQ QMAAAAL--- EELLPQF-II IIEEDLSGHH HIIHHWWWKL RDKNNNVQTL GGAAAHHHQQ QMAAAAL--- EETTDMV-LL LLDDILGGRR RLLHHWWWDL TRRHHHLQEF GGDDDHHHQQ QLVVVVF--- EETTRMV-VV VVDDELAGHH HLLHHWWWDL YRRHHHLQTL GGAAAYYYQQ QMAAAAL--- EETTNMI-LL LLQQILNGRR RLLHHWWWDL RRRHHHLQAV GGEEEHHHQQ QMVVVVL--- EEAANVFFNN NNHHVA-GSS SIIFFWWWDW QREIIIIQTM TT---DDDGG GLIIIIP--- EEAANVFFNN NNHHVA-GSS SIIHHWWWDW QREIIIIQTM KK---DDDGG GLIIIIP--- EEAANVFFNN NNDDVA-GSS SLLHHWWWDW QREIIIIQTL QQ---DDDGG GLIIIIP--- EEAANVLFNN NNDDVA-GSS SLLYYWWWDW QREIIIVQTL QQ---DDDGG GLIIIIP--- EEAANVLFNN NNDDVA-GSS SLLYYWWWDW QHEIIIVQTL KK---DDDGG GLIIIIP--- EEAANVLFNN NNDDVA-GSS SLLYYWWWDW QREIIIVQTL KK---DDDGG GLIIIIP--- EEAANVLFNN NNDDVA-GSS SLLYYWWWDW QREIIIVQTL KK---DDDGG GLIIIIP--- EEAANVLFNN NNDDVA-GSS SLLYYWWWDW QREIIIVQTL KK---DDDGG GLIIIIP--- EEAANVVFNN NNDDVA-GKK KLLHHWWWDW QREIIIVQTM PP---DDDGG GHIIIIP--- ---------- ---------- ---------- ---------- ---------- ---------- IIHHNLRSRR RRPPAA-AGG GTT------- ---------- ---------- ---------- IICCLFYAEE EECCLA-HVV VSSCCDDDNY IMVIIIDESL QQ---DDDQQ QAGGGGANPP EEAAKAFFKK KKEEVA-GHH HLLNNWWWDW TERRRRIQTL GGEEEDDDGG GLIIIIP--- EEAAKAFFKK KKDDVA-GHH HLLNNWWWDW TERLLLVQTL GGKKKDDDGG GLIIIIP--- SSAATAFFDD DDHHVD-GRR RLLTTIIIQL ARELLLRQTL GGNNNTTTGG GLLLLLP--- SSAAKAFFNN NNHHVD-GRR RLLHHYYYSW PGEIIIKQTL GGDDDKKKGG GLLLLLP--- SSAAKAFFDD DDHHVD-GSS SLLHHYYYSW PGEMMMKQLL GGEEETTTGG GLLLLLP--- SSAAKAFFNN NNHHVD-GSS SLLHHYYYSW PGEIIIKQLL GGPPPTTTGG GLLLLLP--- SSAAAAFFDD DDHHVD-GRR RLLHHYYYDW PGELLLKQTL GGSSSTTTGG GLLLLLP--- EESSNHIFNN NNHHVE-GNN NVVHHFFFEW DSKYYYLQTL PPQQQLLLGG GALLLLP--- EESSNHIFNN NNHHVE-GNN NVVHHFFFEW DTKHHHLQTL PPMMMRRRGG GALLLLP--- LLGGVTVEEE EECCQE-IKK KKKRRYYY-- ---------- ---------- ---------- EEAAKLFYHH HHDDCDRGCC CLLNNYYYRW QEELLLFQTL GGDDDDDDGG GLTTTTP--- EEAANKWWKK KKDDLDMGCC CLLNNYYYKW STTLLLYQTL GGSSSDDDGG GITTTTP--- RREEIMASEE EELLKTGPQQ QVVAAVVVL- ---------- ---------- ---------- SSGGSMMQMM MMDDAAMGNN NIIVVWWWDL HTQPPPKKVV PPGGGPPP-- ---------- SSGGNMMKMM MMDDPAMGNN NVVVVWWWDL HTQPPPKKVV PPGGGPPP-- ---------- --RRRRPHTK KKGGIIIINV SLKDSWLLWF YYYY-EEDKK KWWKKVVEII PAEEPLLGGG --RRRRPHTK KKGGVVVVNV NTKDSWLLWF YYYY-EEDKK KWWRRVVDII EAQQPFFGGG --RRRRPHVR RRGGVVVVGV DTTNSWTTWW RRRR-EEGKK KFFKKTTTII PAEEPAAAAA --RRRRPHVR RRGGVVVVGV DTTNSWTTWW RRRR-EEGKK KFFKKTTTII PPEEPAAKKK --RRRRPHSK KKGGCCCCGV DTTNAFTTWW QQQQKDDDTT TFFKKTTTII DPVVPAAAAA --RRRRPHTK KKGGVVVVNV SLKDSWTTWY RRRR-DDKKK KWWKKVVEII PAEEAAAPPP --RRRRPHTK KKGGMMMMNV SLKDSWLLWY RRRR-DDNSS SWWKKVVDII PAEEPAAEEE --RRRRPHAR RRGGVVVVGV SLEDSWLLWH RRRR-QQNSS SWWKKVVEII PAEEPAAPPP --RRRRFHSA AAGGVVVVGA SSNIYNEEEG ---------- -------WSS VEKKVIIVVV --RRRRFHDA AAGGVVVVGA SSNIYNEEGG ---------- -------WSS VEKKVIIVVV --RRRRFHDA AAGGVVVVGA SSTIYNQQGG ---------- -------WSS VEKKVIIVVV --RRRRFHDA AAGGVVVVGA SSTIFNEEDG ---------- -------WSS AQKKVIIVVV --RRRRFHDA AAGGVVVVGA SSTIYNEEGG ---------- -------WSS VEKKVIIVVV --RRRRFHDA AAGGVVVVGA SSTIYNEEGG ---------- -------WSS VEKKVIIVVV --RRRRFHDA AAGGVVVVGA SSTIYNEEGG ---------- -------WSS VEKKVIIVVV --RRRRFHDA AAGGVVVVGA SSTIYNEEGG ---------- -------WSS VEKKVIIVVV --RRRRFHAA AAGGVVVVGA SSTIYNEEGG ---------- -------WSS VEKKVIIVVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIRRRRSHNI IIDDDDDDVE SFSGSPDDAY ---------- -------VVV LKRRKLLLLL --RRRRFHDA AAGGVVVVGA SSTVYEKKDG ---------- -------WAA AEKKVIIVVV --RRRRFHDA AAGGVVVVGA SSSIYEKKDG ---------- -------WAA AEKKVIIVVV --RRRRFHAK KKGGVVVVGA SSNMFTQQDG ---------- -------WSS HELLAIIVVV --RRRRFHAK KKGGVVVVGA TSNMFTQQDG ---------- -------WNN HEIIVIIVVV --RRRRFHSK KKGGVVVVGA SSNMFNSSDD ---------- -------WSS YEIIVIIVVV --RRRRFHSK KKGGVVVVGA SSNMFNSSDE ---------- -------WSS HEVVVIIVVV --RRRRFHSK KKGGVVVVGA TSNMFTAADG ---------- -------WSS HEVVAIIIII --RRRRFHTS SSAAVVVVGA GSGIHVEEEN SSSS------ ---TT--HAA ATLLVAAIII --RRRRFHTS SSAAVVVVGA GSAIHDEEKN PPPP------ ---KK--QTT ASLLVAAIII ---------- ---------- ---------- ---------- ---------- ---------- --RRRRFHRE EEGGVVVVGA XXXXX----- ---------- ---------- ---------- --RRRRFHKK KKGGVVVVGA NAKVKKSSDS DDDD------ ---EEFFAKK KVIIDIIGGG ---------- ---------- ---------- ---------- ---------- ---------- --RRRRFWNA AAAASSSSTA TSQLYDDDAG ---------- ---------- -------WWW --RRRRCWAH HHCCTTTTSA TSQLYDGGEG ---------- ---------- -------WWW GNEEEILKFK KKLLVVDDDI KFFLLLLWGE EVVQSFFPPP VKKKVLGFHH HRADHHHPP- GPPPPVLKFK KKLLVVDDDI RFFLVVLWGE ELLQTHHPPP RRRRVIGYHH HREPHHHPP- AEPPPLLQFG GGLLVVDDDL RFFLVVCWGE EMMQSHHPPP VSSSVIGARR RRAPHHHPP- KKPPPLLQFG GGLLVVDDDL RFFLVVCWGE EMMQSRRPPP KSSSVIGARR RRTPHHHPP- ADDDDLLKFG GGLLVVDDDL KYYLVVCWGE EMMQSMMPPP VKKKVIGVKK KKTPHHHPP- PQPPPVLKFK KKLLVVDDDL RFFLVVCWGD DLLQSFFPPP KKKKVIGVSS SRATHHHPPG EQPPPILKFK KKLLVVDDDL RFFLVVCWGE ELLQSFFPPP RKKKVIGVRR RRAGHHHPP- PQPPPLLKFG GGLLVVDDDL RFFLVVCWGE ELLQSFFPPP RSSSVLGVRR RKAAHHHPP- VSVVVKGWLP PPLLIIDDDL RFFLFFNWLD DIIQSQQPPP RQQQILGIVV VRGGSSSVVQ VSVVVKGWLP PPLLIIDDDL RFFLFFNWLD DIIQSKKPPP RQQQILGIVV VKGGSSSVVQ VPVVVKGWLP PPLLIIDDDL RFFLFFNWLD DLLQSQQPPP RQQQLLGIVV VKGGPPPVVQ VPVVVKGWLP PPLLIIDDDL HFFLFFNWLD DIIQSQQPPP RQQQLLGIVV VKDGPPPVVQ VPVVVKGWLP PPLLIIDDDL RFFLFFNWLD DLLQSQQPPP RQQQLLGIVV VKGGPPPVVQ VPVVVKGWLP PPLLIIDDDL RFFLFFNWLD DLLQSQQPPP R--------- ---------- VPVVVKGWLP PPLLII---- ---------- ---------- ---------- ---------- VPVVVKGWLP PPLLIIDDDL RFFLFFNWLD DLLQSQQPPP RQQQLLGIVV VKGGPPPVVQ VPVVVKGWLP PPLLIIDDDL RFFLFFNWLD DMMQSKKPPP RQQQILGIVV VKGGPPPVVQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LYVVVAKFVV VVEEFFPPPI LLLIFFS--- ---------- ---------- ---------- VSVVVEGWLP PPLLIIDDDI RFFLFFNWLD DIIQTRRPPP KQQQILGILL LRGGPPPVVT VSVVVEGWMP PPLLIIDDDI RFFLFFNWLD DIIQTRRPPP KQQQILGIQQ QRGGPPPVVT VPVVVQNWLP PPLLIIDDDI RFFLFFNWLD DIIQEKKPPP VQQQLVGIQQ QKGSPPPVVA VPVVVQNWLP PPLLIIDDDI RFFLFFNWLD DIIQEKKPPP KQQQVAGIQQ QKGSPPPVVV VPVVVENWLP PPLLIIDDDI RFFLFFNWLD DIIQEKKPPP VQQQIVGLQQ QKGSPPPVVK VPVVVENWLP PPLLIIDDDI RFFIFFNWLD DIIQEKKPPP VQQQIVGLQQ QKGSPPPVVK IPVVVRNWLP PPLLIIDDDI RYYLLLNWLD DIIQEAAPPP VQQQVAGLQQ QKGSEEEVVV ISVVVSGWLP PPLLIIDDDI RFFLVVCWLD DIIQSLLVVV KQQQVIGVHH HTESNNNVVK ISVVVENWLP PPLLIIDDDI RFFLVVCWLD DIIQSKKPPP KQQQVIGIHH HSETTTTVVK ---------- ---------- ---------- ---------- ---------- ---------- --GGGENGIE EEMMMMDDDI RYYLFFNWRD DVVQSAAPPP RQQQVLGIQQ QRDAPPPRRR GLTTTGSGAE EEMMIIDDDI RFFLVVCWRD DVVQTEEPPP KQQQLLGICC CSDLPPPNNV ---------- ---------- ---------- ---------- ---------- ---------- WAVVVADINP PPLLPPDDDI QTTLIISFMK KTTLSHHPPP FEEEKIDVNN N--------- WAVVVADIEP PPLLPPDDDI SRRLVVTFMK KTTLSHHPPP REEEKIGVNN N--------- ---------- ----AAHKKL LLTGAAAPPL EEEIRRDRVY NSSSLYWDDD NQQQYYEGLL ---------- ----SSAEEA AATGAAAPPI SSSVRRDRVY NSSSLYWNNN NQQQYY-GLL ---------- ----NNRTTF FFAGGGGPPV EEEIRRDRVY NSSSLYWDDD DQQQYYDGVV ---------- ----NNKAAF FFAAGGGPPV EEEIRRDRVY NSSSLYWDDD DQQQYYDGVV ---------- ----NNKTTF FFGYGGGPPV EEEIRRDRVY NSSSLYWDDD EQQQYYGDRR G--------- ----KKGAAL LLNGGGGPPV EEEIRRDRVY NSSSLYVDDD PQQQYYEGII ---------- ----TTAEEL LLNGGGGPPV EEEIRRDRVY NSSSLYWDDD EQQQYYDGII ---------- ----AAGPPL LLNGGGGPPV EEEVRRDRVY NSSSLYWDDD EQQQYYVGII QLQQQEECCQ PPEPKKKRRI IIPGGGGPPI QQQLLLDRLY TSSSLYWDDD KQQQYYPDLL QLQQQEECCQ PPEPKKKRRV VVPGGGGPPI QQQLLLDRLY TSSSLYWDDD KQQQYYPNLL QLQQQEESSQ PPEPKKKKKV VVPGGGGPPI QQQLLLDRLY TSSSLYWDDD KQQQYYPDLL QLQQQEESSQ PPEPKKKQQV VVAGGGGPPI QQQLLLDRLY TSSSLYWDDD KQQQYYPDLL QLQQQEESSQ PPEPKKKRRV VVAGGGGPPI QQQLLLDRLY TSSSLYWDDD KQQQYYPDLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QLEEEEESSQ PPEPKKKRRV VVAGGGGPPI QQQLLLDRLY TSSSLYWDDD KQQQYYPDLL QLQQQEESSQ PPEPKKKRRV VVPGGGGPPI QQQLLLDRIY TSSSLYWDDD KQQQYYPDLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TLKKKDDCCQ PPDPKKKKKV VVPGGGGPPI QQQLLLDRLY NSSSLYWDDD KQQQYYPDMM TLKKKEECCQ PPDPKKKIII IIPGGGGPPI QQQLLLDRIY SSSSLYWDDD KQQQYYPDLL AIDDDGGWWQ SSDVQQQKKL LLRGGGGPPI QQQLLLDRLY NSSSLFWDDD KQQQYYPGLL VVDDDGGWWQ SSDVQQKKKL LLRGGGGPPI QQQLLLDRLY NSSSLFWDDD KQQQYYPKLL KVDDDGGFFQ FFDVKKKSSL LLRGGGGPPI QQQLLLDRLY NSSSLFWDDD RQQQYYPELL KVDDDGGFFQ FFEVKKKSSL LLRGGGGPPI QQQLLLDRLY NSSSLFWVVV VSSSYYPEII VVDDDDDEEQ YYSVKKHRRL LLRGGGGPPI QQQLLLDRIY NSSSLFWDDD EQQQYYQDLL KLEEEKK--P IIEAKKRKKI IIEGGGGPPL QQQLLLDRLY TSSSLYWDDD DQQQYYPEHH KLDDDHH--E IIPAKKRQQI IIEGGGGPPL QQQLLLDRLY TSSSLYWDDD DQQQYYPENN ---------- ---------- ---GGGGPPI QQQLVVDRLY NSSSFYWDDD KQQQYYPNVV RLPPPEEEEA PPEPKKRRRL LLLGGGGPPL QQQLLLDRLY SSSSLFWDDD KQQQYYPEMM VVKKKEEEER PPPAKKRRRL LLEGGGGPPL QQQLLLDRLY SSSSLYWDDD KQQQYYPKMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------V SSSQWWDRVY SSSSLLWDDD ---------- ---------- ---------- ---------V SSSSWWDRLY SSSSLLWDDD ---------- KGWWMVKNNN A--SSSLLDF FVVFFFFGE- ---ARRSHVL LSSGGASSSS DSYCYY---- RGWWMAKNNN V--EEELLEF FVVFFFFGR- ---ARRAHVL LWWGGATTTT DSFCYY---- PAAAQVLHHH A--DDDLLAW WVVFFFFPDG ---YRRAHIL LEEGGCTTTT DSFCYYVKRR PGVVEVMNNN V--NNNLLDF FVVFFFFPDG ---YRRAHIL LEEGGCTTTT DSFCYYV--- GAAAMVMNNN V--NNNLLDW WVVFFFFPAG ---YRRSHIL LEEGGCTTTT DSFCYYV--- DGWWMVKDDD A--NNNIIDF FLLWWWWPKG ---HRRPHVL LQQGGCSSSS DSYCYY---- KGWWMVKDDD V--DDDMMDF FVVFFFFGE- ---QRRVHIL LQQGGASSSS DSYCFF---- RGWWIAKEEE A--GGGLLDF FTTVVVVGDG ---LRRPHIL LEEGGSSSSS DSYCYY---- IREEGSVLLL QDDNNNLLNL LVVFFFFGKE PLGALLAHLY YPPGGCSSSS DIWI------ IREEGSVLLL QDDNNNLLNL LVVFFFFGKE PLGALLAHLY YPPGGCSSSS DIWI------ IREEGSVLLL QDDKKKLLNL LVVFFFFGKE PLGALLAHLY YPPGGCSSSS DIWL------ IREEGSVLLL QDDKKKLLNL LVVFFFFGKE PLGALLAHLY YPPGGCSSSS DIWL------ IREEGSVLLL QDDKKKLLNL LVVFFFFGKE PLGALLAHLY YPPGGCSSSS DIWI------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IREEGSVLLL QDDKKKLLNL LVVFFFFGKE PLGALLAHLY YPPGGCSSSS DIWI------ IREEGSVLLL QDDKKKLLNL LVVFFFFGKE PLGALLAHIY YPPGGCSSSS DIWL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IKEEGSVLLL QDDKKKLLNL LVVFFFFGKE PGGVLLAHLY YPPGGCSSSS DIWV------ LKEEGAVLLL QDDKKKLLNL LVVFFFFGKE PDGVLLAHIY YPPGGCSSSS DIWI------ VEKKGSHLLL QDDKKKLLNF FVVFFFFGAE PDGALLAHMY YPPGGCSSSS DIWI------ VEQQGSHLLL QDDNNNLLNF FVVFFFFGAE PDGSLLAHMY YPPGGCSSSS DIWI------ MDKKGSHIII QDDKKKLLNF FVVFFFFGDE PEGALLAHMY YPPGGCSSSS DIWI------ MEKKGSHIII QDDKKKLLNF FVVFFFFGDE PDGSLLAHMY YPPGGCSSSS DIWI------ VKKKGSHLLL QDDKKKLLNF FVVFFFFGAE PEGSLLAHMY YPPGGCSSSS DIWI------ VKSSGATVVV QNDSSSMMNL LIIFFFFGKI EGGYLLAHMY YPPGGCSSSS DIWI------ VRSSGATLLL QDDTTTMMNL LIIFFFFGKV PGGYLLAHMY YPPGGCSSSS DIWI------ VKEEGSVLLL QDDKKKLLNL LVVFFFFGKE PNGCLLAHIF FPPCGSSSSS DILA------ VAAAGGTVVV QDDNNNMMNL LVVFFFFGGE PYGGLLPHM- ---------- ---------- VSQQGGHVVV LDDNNNIINL LVVFFFFANE PYGSLLPHMY YPPGGCSSSS DIWLAAA--- ---------- ---------- ---------- ---------- ---------- ---------- -KKKGKDAAA QLAWWWKKVA AVVFFFFYEL GLG-RRAHMF FGGSSLSSSS S--------- -KKKGKDEEE QLLWWWKKKA AIIFFFFYAE KLG-RRPHMF FGGARLAAAA GPAGDDRLVV ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QARVVEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNAAKKQQP SSETTTVPPT AARLLLLADG QQSLLTTTAA QQLLLSSLLL LLGSSSVRIA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AQEAAWTAVL APSSSKKTTS SPPGGVVESA VAKQVVVPQA VVVQWWHHHH LPPPGGGGAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AEERRRGAF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMMM LGKKEEEGHT ---------- ---------- ---------- ---------- ----LLKKKK SQGGCCCFDQ ---------- ---------- ---------- ---------- ---------- ---------- -AGSSAPPNR TPPPPLLSSP PPPRRPPLLV RPYRTIINPP LLLPCCPPPP ARHHSSSLQH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MKRRRRRG-- ---------- ---------- ---------- ---------- ---------- MKRRFFFSGP ---------- -AAAAAPPPF RDPPSPKKMM MKKAPPPPPP DDAAYVAAAL LYTTTTTTNN ---------- ------KKKL PDPPTPRRDM MRRAPPPPPP DDAAYVAAAL LYVVVVTTNN ---------- ------SSSM PDPASPEELM MQQAPAAAAA EEAAYTLLLL LSPPPPFF-- ---------- ------TTTM PDPASPKKLM MEEAPAAAAA NNAAYTLLLL LSPPPPFF-- ---------- ------TTTL PDPPSAKKLM MEEGPVVVVV KKAAFTLLLL LSPPPPAA-- ---------- ------TTTW PDPPSPRRLA AKKAPPPPPP TTAAYVAAAF FDPPPPRR-- ---------- ------TTTW PDPPSPRRMV VKKAPAAAAA KKAAYVVVVL LNPPPPAA-- ---------- ------SSSW PDPPSPKKMM MQQAPRRRRR RRGGYVAAAL LDPPPPRR-- ---------- -KKKKKKKK- CGPTPLEEAK K--GPRRRRR EEVVYLPPPI IYRRRRTTEE ---------- ---------- ---------M M--GPRRRRR EEVVYLPPPI IYRRRRTTEE VVLLIIPARG GQQQQQKKK- CGPSPLEEAK K--GPRRRRR EEVVYLPPPI IYGGGGTTEE ---------- ---------- ---------K K--GPRRRRR EEIIYLPPPI IYRRRRTTEE ---------- -KKKKKNNN- CGPTPLEEAK K--GPRRRRR EEVVYLPPPI IYRRRRTTEE TTLLQQVAQP IKKKKKNNN- CGPTPLEEAK K--GPRRRRR EEVVYLPPPI IYRRRRTTEE ---------- -KKKKKNNN- CGPTPLEEAK K--G------ ---------- --------EE ---------- -KKKKKNNN- CGPTPLEEAK K--GPRRRRR EEVVYLPPPI IYRRRRTTEE AAQQPPFLSG QKKKKKDDD- CGPTPQEEAK K--GPRRRRR EEVVYLPPPI IYRRRRTTEE TTNNTTLHTY VKKKKKNNN- CGPTPLEEAK K--GPRRRRR EEVVYLPPPI IYRRRRTTEE ---------- -KKKKKNNN- CGPTPLEEAK K--GPRRRRR EEVVYLPPPI IYRRRRTTEE IIMMEEAAAV ATTTTTHHHT KGPTPLEEAE EKKGPRRRRR KKVVYVTTTV VYNNNNTTNN ---------- ---------- ---------- ---------- ---------- ---------- ---------- -KKKKKSSS- CGPSPLDDAK K--GPRRRRR EEVVYLPPPI IYRRRRTTNN --MMAAVLDH NVVVVVCCCC SGPSPIEESS S--GPRRRRR SSIIYVTTTV VYAAAATTEE --MMGGVLQH SQQQQQCCCC SGPSPLEEAS S--GPRRRRR TTIIYVTTTV VYAAAATTEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------LLLQ GGPTPLAAAS S--GPSSSSS KKIIYVTTTV VYTTTTTTDD ---------- AAAAAAGGGG TGPTPLEEAE EKKGPRRRRR KKLLYVTTTV VYNNNNTTNN ---------- SKKKKKGGG- -GPSPADDAK K--GPRRRRR EELLFVTTTP P-----NNDD ---------- PKKKKKGGG- -GPSPADDAK K--GPRRRRR EELLFVTTTP P-----HHDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -SSSSSKKKC CGPTPLDDAR RNNGPVVVVV KKLLYVVVVV VQPPPPLLEE ---------- ---------- ---------R RSSGPRRRRR KKLLYTVVVV VQPPPPLLPP ---------- ---------- -MPT--DDII ISSLDDDDDD FFYYFSNNNL LHGGGGIIYY ---------A GGGGGGFFFR FADQSPYYMK KIITGQQQQQ EEVVYVWWWL LGVVVVGGDD SSMMHHALRA GAAAAAAAAG RADASPYYMK KIITGQQQQQ DDVVYVWWWL LGAAAAGGDD RAADDFFIAV VVNPTYYYYY YKKKKKEEEE LYYINDWAAS SALL--KPNN IERRRLIVVP APPDDFFLAV VVDPTYYYYY YKKKKKDDDD LYYIGDWAAS SAYY--KPFF LERRRLIVVP RPPDDAALAV IIKPTYYYYY YKKKKTTTTT MNNTGDWAAS SSLL-GHAFF LERRRLIIIP KPPDDAALAV IIKPTYYYYY YQQQQTTTTT MNNKGDWAAS SALL-GHAFF IERRRLIIIP KPPDDGGLAV VVDPKFFFFF FQQQQQIIII MNNKGDWAAS SALL-GHAFF LERRRLIIIP QPPDDAAIAV VVDPRYYYYY YSSSSQAAAA MHHAGDWAAS SCLL-PHPHH MERRRLVVVP KPPDDAAMCV VVDSTFFFFF FQQQQVDDDD MYYTGGWAAS SMLL-PHPHH VERRRLVVVP RPPDDAALGV LLDPTYYYYY YQQQQREEEE MNNAADWAAS AALL-PHPHH VERRRLIVVP APPDDYYLAT VVDPQYYYYY YQQQQRPPPP MYYLKDWTTS SC---GDSTT KSRRNLILLP APPDDYYLAT VVDPHYYYYY YQQQQRPPPP MHHLKDWTTS SC---GDSTT KSRRDLILLP APPDDYYLAT VVDPQYYYYY YQQQQRPPPP MNNLRDWAAS SC---GDSTT KSRRTLMLLP APPDDYYLAT VVDPQYYYYY YQQQQRPPPP MHHLKDWTTS SC---GDITT KARRTLVLLP APPDDYYLAT VVDPQYYYYY YQQQQRPPPP MNNLKDWTTS SC---GDSTT KSRRTLVLLP APPDDYYLAT VVDPQYYYYY YQQQQ----- ---------- ---------- ---------- APPDDYYLAT VVDPQYYYYY YQQQQRPPPP MNNLKDWTTS SC---GDSTT KSRRTLVLLP APPDDYYLAT VVDPQYYYYY YQQQQRPPPP MNNLKDWTTS SC---GDSTT KSRRTLVLLP APPDDYYLAT VVDPQYYYYY YQQQQRPPPP MYYLKDWTTS SC---GDSTT KSRRNLVLLP APPDDYYLAT VVDPQYYYYY YQQQQRPPPP MNNLKDWTTS SC---GDSTT KSRRTLVLLP APPDDYYLAT VVDPQYYYYY YQQQQRPPPP MNNLKDWTTS SC---GDSTT KSRRTLVLLP KLLDDYYLAT VVDPTYYYYY YQQQQRPPPP VHHIGDWSSS SC---GDPSS AKRRRLILLP ---------- ---------- ---------- MNNTNDWTTS SC---GDASS KVRRNLILLP KPPDDYYLAT VVDPSYYYYY YQQQQRPPPP MNNVNDWTTS SC---GDSSS KVRRNLILLP KPPDDYYLAT VVDPTYYYYY YKKKKRPPPP VYYVGDWSSS SC---GDPSS AERRRLIAAP KPPDDYYLAT VVDPTYYYYY YKKKKRPPPP VYYVGDWSSS SC---GDPSS AQRRRLIVVP ---------- ---------- ---------- MFFVGDWSSS SC---GDASS ADRRRLVLLP KPPDDYYLAT VVDPSYYYYY YSSSSRPPPP MFFVGDWSSS SC---GDASS VDRRRLVLLP KPPDDYYLGT VVDPTYYYYY YQQQQRPPPP VHHVGDWAAS SC---GDPSS ASRRRLILLP GPPDDAAIFT VVNPTFFFFF FQQQQRDDDD VHHIGDWAAS SC---DKPTT EKRRSLIVVP GPPDDAAIFT VVNPTFFFFF FQQQQRDDDD VNNIGDWAAS SC---DKPTT EKRRSLIVVP ---------- ---------- ---------- ---------- ---------- -----MVPPR HGGDDYYLAT VVDPTYYYYY YQQQQRYYYY TSSKHNWTTS SCHHVGKEVV PTRRDLVLLP HGGDDYYLST VVDPTYYYYY YQQQQRFFFF TRRKGDWAAS SCYYVSKTVV PKRRDLVLLP DIITTDDRKN PPVGLGGGGG GSSSSDPPPP VVVLEDPPPI LK---GKRVV QGGGPMLQQL EQQDDKKLVT IIRPTRRRRR RQQQQSSSSS VGG-RNFAA- ---------- -DRRRFWTTG EQQDDKKLVT VVNPQYYYYY YKKKKTSSSS VGG-RNFDD- ---------- -DRRRLWAAG RRRSSSIIII IIIDDTPPPP NPPIIKVEEP EEVKKKKSGY YRLHTTHCDD IYILNE---E RRRSSSIIII VVVDDTPPPP DKKAAKIEEP VVAVVGGTGY YKYHTTHCDD IYILGP--RE RRRSSSIIVV IIIDDTPPPP HPPHHKIEEP EEILLAATGY YRPHTTHCEE IYVLGAGGTD RRRSSSIIII IIIDDTPPPP DPPHHKIEEP EEVFFKKTGY YRPHTTHCDD IYVLGGGGTN RRRSSSIIII VVVDDV---- EPPHHKIEEP EEVFFAATGY YRPHTTHCEE IYVLGGGGTD RRRSSSIIII LLLDDTPPPP DPPAAKVEEP TTLAAEETGY YRPHTTHCGG IYVLNA---K RRRSSSIIII LLLDDTPPPP DPPVVKVDDP EELAAEETGY YRPHTTHCDD IYILSP---E RRRSSSIIII VVVDDTPPPP DPPVVKVEEP EELHHRRTGY YRPHTTHCDD VYVLSP---D MMMSSSIIVV VVVDDVSSSS EPPHHKVEEA EEIQQAACNV VNTHTTHCSS EVMTGD--GN IIISSSIIVV VVVDDVSSSS EPPHHKVEEP EEIHHAACNL LNLHTTHCSS EVMSGD--GN MMMSSSIIVV VVVDDVSSSS DPPHHKVEEA DDIHHAACGL LYVHTTHCSS EVMTGD--GN IIISSSIIVV VVVDDVTTTT EPPHHKVEEP DDIHHTTCNL LFFHTTHCSS EVMTGD--GN IIISSSIIVV VVVDDVSSSS EPPHHKVEEP DDIHHAACEL LFLHTTHCSS EVMSGD--GN ---------- ---------- ---------P DDIHHAACEL LFLHTTHCSS EVMSGD--GN IIISSSIIVV VVVDDVSSSS EPPHHKVEEP DDIHHAACEL LFLHTTHCSS EVMSGD--GN IIISSSIIVV VVVDDVSSSS EPPHHKVEEP DDIHHAACEL LFLHTTHCSS EVMSGD--GN IIISSSIIVV VVVDDVTTTT EPPHHKVEEA DDIHHEECGL LTPHTTHCTT EVMTGD--GN ---------- ---------- ---------- ---------- ---------- ---------- IIISSSIIVV VVVDDVSSSS EPPHHKVEEP DDIHHAACEL LFLHTTHCSS EVMSGD--GN LLLSSGVVVV VVVDDTTTTT DPPHHKVEES DDIAAEEIGL LFPHTTHCSS DIMCGD--GN IIISSSIIVV VVVDDVTTTT DPPHHKTEEP EEVFFWWCGL LNLHTTHCCC EIMSGD--GN IIISSSIIVV VVVDDVSSSS DPPHHKTEEP EEVFFWWCGL LNPHTTHCCC EIMSGD--GN VVVSSGIIVV IIIDDTTTTT NPPHHKVDDP DDIIIQQTGL LYPHTTHCSS ELMCGD--GN VVVSSGVVVV IIIDDTTTTT NPPHHKVEEP DDISSTTTGL LYPHTTHCSS EIMCGD--GN IIISSGIIAA IIIDDTEEEE NPPYYKYDDP EEIAAEETGL LYPHTTHCSS EILCGD--GN IIISSGIIAA IIIDDTEEEE NPPYYKYDDP EEIAADDTGL LFPHTTHC-- EILCGD--GN LLLSSGVVVV VVVDDTKKKK DPPHHKVEEA DDIAAEETGL LFPHTTHCSS EIMCGD--GN NNNSSDIIII IIINNVNNNN E--EEHTEEP KKLHHSSN-L LFPHTTHCDD NIMTGE--GT NNNSSDIIVV IIINNVNNNN E--QQHTEEP KKLHHAAN-L LFPHTTHCDD NIMTGE--GS SSSSSGEEKK VVVFFVGGGG ---------- ---------- ---------- ---------- NNNSSDIIVV IIIDDTTTTT DPPAAKVEEG DDVLLKKADC CAPHTTHCNN NIMIGD--GN NNNSSDIIII LLLDDVTTTT DPPVVKTDDG DDVLLKKHNV VAPHTTHCNN NIMVGD--GY DDDGGKLLVV TTTTTSYYYY SAAYYP---- DDLIIKKLVL LISHTTDYNN ALKGNE--SV DDDTTNIIII FFFDDVSSSS DPPHHKTDDT FFVKKDDGGV VGPHTTFAGG MMILND--HG DDDTTSIIVV FFFDDVSSSS DPPSSKTTTD FFVEEKKGGV VGPHTTYAGG MLILNN--HG GGPGGGIILL MDHYSSSSEL GGGGKWEIID DRRRGGGDDQ QY-------- -------AYY GGPGGGIIFF LDHDTTTTEI GGGGRWEVVY YRRRGGGPPQ QY-------- -------AYY GGAPGGIIFF IDCETTTTDL GGGGRWEIID DRRRGGGPPQ QD-------- -------HYY GGPPGGVVFF IDCETTTTEL GGGGRWEIID DRRRGGGPPQ QT-------- -------HYY GGPPGGIIFF IDCETTTTEL GGGGRYEMMD DRRRGGGEEQ QT-------- -------HYY GGPGGGIIAA MDAQSSSSEL GGGGRWEVVE ERRRGGGPPQ QY-------- -------AYY GGPGGGIIFF IDHDNNNNEL GGGGRWEIID DRRRGGGDDQ QY-------- -------HYY GGPGGGVVFF VDHESSSSDL GGGGRWEVVE ERRRGGGPPQ QQ-------- -------AYY GGKGSSFFVV LDGETTTTEK GGGGTWEKKP PGGGGGGAAS SP-------- -------GYY GGKGGGFFVV LDGETTTTEK GGGGTWEKKP PGGGGGGEEA AP-------- -------GYY GGKGGGFFVV LDGETTTTEK GGGGTWEQQP PGGGGGGAAA AP-------- -------GYY GGKGGGFFVV LDGKTTTTEK GGGGTWEQQP PGGGGGGAAA AP-------- -------GYY GGKGGGFFVV LDGETTTTEK GGGGTWERRP PGGGGGGAAA AP-------- -------GYY GGKGGGFFVV LDGETTTTEK GGGGTWERRP PGGGGGGAAA AP-------- -------GYY GGKGGGFFVV LDGETTTTEK GGGGTWERRP PGGGGGGAAA AP-------- -------GYY GGKGGGFFVV LDGETTTTEK GGGGTWERRP PGGGGGGAAA AP-------- -------GYY GGKGGGFFVV LDGETTTTEK GGGGTWERRP PGGGGGGSSA AP-------- -------GYY ---------- ---------- ---------- ---------- ---------- ---------- GGKDGGSSLL VLP-RRRRES GGGG------ ---------- ---------- ---------- AAAGNNGGFF LLDSEEEENK GGGGRGSNNR RLLLFFFPPI IS-------- -------ERR GGKGGGFFVV LDGETTTTEK GGGGNWEAAE EGGGEEEAAA AP-------- -------GYY GGKGGGFFVV LDGETTTTEK GGGGNWEVVE EGGGEEESSA AQ-------- -------GYY AAEGNNGGFF LLDSDDDDNK GGGGRWEKKP PGGGHHHSSP PL-------- -------GYY AAEGNNGGFF LLDSEEEENK GGGGRWEKKP PGGGHHHSSP PL-------- -------GYY AAKGNNGGFF LLDSDDDDNK NNNNRWEKKP PGGGHHHSSP PL-------- -------GYY AAKGNNGGLL LLDSDDDDNK NNNNRWEKKP PDDDIIISSP PL-------- -------GYY AAAGNNGGFF LLDSEEEENK GGGGRWEKKP PGGGHHHSSP PL-------- -------GYY PPSGNNFFLL LDGKTTTTEK GGGGTWPAAD DEEEKKKTTV VP-------- -------NYY PPSGNNFFLL LDGKTTTTEK GGGGTWPAAD DGGGKKKVVV VP-------- -------NYY ---------- ---------- ---------- ---------- ---------- ---------- AAKG--DDFF VFDKNNNNEV GGGGTWSRRG GDDDRRRKKA AL-------- -------GYY AAKG--DDFF IFDSDDDDNI GGGGTWTKKG GDDDKKKKKA AL-------- -------GYY PPVLNNGGII QSKHEEEEGS AAAAKGEAAS SQQQFFFEEE EI-------- -------QLL GGRTAALLVV ENDDGGGGYA TTTTYWMPPT TAAADDDDDM MQGVAAAAAG GAVAAGGGYY GGRTAALLVV ETNAGGGGYA TTTTHWIPPT TDDDGGGDDL LRGIKKKKKG GKYAAGGDYY DWWWLLPLLL LSSEAPN--- TIEEDDD--K KLLEHK--RN NHFFDLRRKI SLLTLLEENN DWWWLLPMMM MTSETPR--- CFEEEEE--S SLLECKGGAN NHVVDLARRL AIIDLLEEHH DWWWLLPMMM MSSEAPP--- QFEENNN--V VPPEDLNNKH HHFFDLRRRV TIIDLLQQHH DWWWLLPMMM MTSEAPP--- QFEENNN--V VPPEDLNNKH HHFFDLRRRV TIIDLLNNHH DWWWLLPMMM MSSEGPP--- QFEENNN--V VPPEDLNNKH HHFFKLRRKV TIIDLLNNHH DWWWLLGLLL LTSEGPD--- MVEEDDD--V VPPDILAARR RHFFDLTRRL EIIDFFEEHH DWWWLLGLLL LTSEGPR--- MVEESSS--L LGGDELGGKH HHVVDLYRRL TLLDLLEEYY DWWWLLGMMM MTSEGPN--- MIEEGGG--D DPPQILKKGR RHIIDLRRRL ALLDVVEEHH DYYYPPRMMM MSTEAPN--- VFKKDDDFFP PAAHVAGGLS SFVVDWQHEI TLLQMM--DD DYYYPPRMMM MSTEAPN--- VFKKDDDFFP PAAHVAGGLS SHVVDWQHEI TLLQMM--DD DYYYPPRMMM MSTEAPN--- VFRRDDDFFP PAADVAGGLS SHVVDWQHEI TLLTLL--DD DYYYPPRMMM MSTEAPN--- VLRRDDDFFP PAADVAGGLS SYVVDWQREV TLLPLL--DD DYYYPPRMMM MSTEAPN--- VLRRDDDFFP PAADVAGGLS SYVVDWQHEV TLLSLL--DD DYYYPPRMMM MSTEAPN--- VLRRDDDFFP PAADVAGGLS SYVVDWQHEV TLLSLL--DD DYYYPPRMMM MSTEAPN--- VLRRDDDFFP PAADVAGGLS SYVVDWQHEV TLLSLL--DD DYYYPPRMMM MSTEAPN--- VLRRDDDFFP PAADVAGGLS SYVVDWQHEV TLLSLL--DD DYYYPPRMMM MSTEAPN--- VVQQNNNFFP PAADVAGGLK KHVVDWQHEV TLLLMM--DD ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AIASN--- LRLLTTTSSD DYYPAASSRG G--------- ---------- TYYYNNAFFF FSWICSL--- FYTTTTTAAL LMMCLASSGV VCLLNYIRVD SLLPLL--DD DYYYPPRMMM MSTEGPK--- AFAALLLFFM MEEEVAGGMH HNVVDWTHRI TIIDLL--DD DYYYPPRMMM MSTEGPK--- AFAALLLFFM MEEDVAGGHH HNVVDWTHRV TIIDLL--DD DYYYPPRMMM MSTSGPT--- AFTTKKKFFL LQQHVDGGLR RTCCQLAGER TLLDLL--TT DYYYPPRMMM MSTSGPK--- AFLLQQQFFL LQQHVDGGLR RHVVSWPGEK TLLDLL--KK DYYYPPRMMM MSTSGPK--- AFSSKKKFFL LQQHVDGGLS SHVVSWPGEK LIIDLL--TT HYYYPPRMMM MSTSGPK--- AFSSKKKFFL LQQHVDGGLS SHVVSWPGEK LIIDLL--TT DYYYPPRMMM MSSSGPA--- AFRRTTTFFL LQQHVDGGLR RHVVDWPGEK TLLDLL--TT DYYYPPRMMM MSTEGPN--- HIKKKKKFFP PAAHVEGGLN NHIIEWDKKL TIIDLLPPLL DYYYPPRMMM MSTEGPN--- HIKKKKKFFP PAAHVEGGLN NHIIEWDKKL TIIDLLPPRR ---------- -SILGPV--- TVCCRRREEL LKKCQEPPLK KRVV------ ---------- DYYYPPHMMM MASEGPK--- LFRRRRRYYP PTTDCDTTQC CNFFRWQREF TIIDLL--DD DYYYPPYMMM MSSEGPN--- KWRRRRRWWN NVVDLDSSQC CNFFKWSQTY TIIDLL--DD SNNNGG-SSS SSDRDPI--- MAFFEEESSS SFFLKTPPLQ QAEEL----- ---------- DAAAIIRMMM MTSSTWSNNY MMDDFFFQQL LQQDAAKKRN NVQQDLHRQK VFFNVVAAPP DAAAPPRLLL LTSSTWNNNY MMDDFFFKKL LAADPAKKHN NVTTDLHKQK VFFDVVAAPP NRM----EEE RRHDDDTTLM IIMMMMMSSS SLLKKLSWWW GGKWAKKVIE EIIAL--PEE HRM----EEE RRHDDDTTLM VVVVVVVNNN NTTKKLSWWW GGKWARRVID DIIAF--PPP HQM----EEE RRHDDDVVEY VVVVVVVDDD DTTTTLGWWW GGKFVKKTAT TIIAADDPPP HQM----EEE RRHDDDVVEY VVVVVVVDDD DTTTTLAWWW GGKFAKKTAT TIIPAEEPPP HQM----EEE RRHDDDSSDY CCVVVVVDDD DTTTTLGFWW GGTFAKKTIT TIIPADDPDD HQL----EEE RRHDDDTTAY VVCCCCCSSS SLLKKLSWWW DDKWVKKVIE EIIAADDPPP YQM----EEE RRHDDDTTAY MMCCCCCSSS SLLKKLAWWW GGSWLKKVID DIIAADDPPP HQM----EEE RRHDDDAATY VVVVVVVSSS SLLEELAWWW GGSWIKKVIE EIIAADDPPP DGL----EEE RRHDDDSSTQ VVCCCCCSSS SSSNNQFNEE --------TW WSSEIPPKVV DGL----EEE RRHDDDDDTQ VVCCCCCSSS SSSNNQFNGG --------TW WSSEIPPKVV DGL----EEE RRHNNNDDAQ VVCCCCCSSS SSSTTQFNGG --------TW WSSEIPPKVV DGL----EEE RRHNNNDDAQ VVCCCCCSSS SSSTTQFNDD --------TW WSSQIPPKVV DGL----EEE RRHNNNDDAQ VVCCCCCSSS SSSTTQFNGG --------TW WSSEIPPKVV DGL----EEE RRHNNNDDAQ VVCCCCCSSS SSSTTQFNGG --------TW WSSEIPPKVV DGL----EEE RRHNNNDDAQ VVCCCCCSSS SSSTTQFNGG --------TW WSSEIPPKVV DGL----EEE RRHNNNDDAQ VVCCCCCSSS SSSTTQFNGG --------TW WSSEIPPKVV DGH----EEE RRHDDDAASQ VVCCCCCSSS SSSTTQFNGG --------TW WSSEIPPKVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DQANNNNCCC RRHWWWNNNQ DDVVVVVSSS SFFSSRGPAA --------AV VVVKLYYVVV DGL----EEE RRHDDDDDAQ VVCCCCCSSS SSSTTFFEDD --------KW WAAEIPPKVV DGL----EEE RRHNNNDDDQ VVCCCCCSSS SSSSSFFEDD --------KW WAAEIPPKVV TGL----EEE RRHDDDAADT VVSSSSSSSS SSSNNIFTDD --------SW WSSEIKKKVV KGL----EEE RRHDDDAADT VVSSSSSTTT TSSNNIFTDD --------SW WNNEIEEKVV TGL----EEE RRHDDDSSDT VVSSSSSSSS SSSNNIFNDD --------TW WSSEIKKKVV TGL----EEE RRHDDDSSDT VVSSSSSSSS SSSNNIFNDD --------TW WSSEIKKKVV TGL----EEE RRHDDDSSDT VVCCCCCTTT TSSNNVFTDD --------SW WSSEIKKKVV LGA----EEE RRHEEETTEH VVCCCCCGGG GSSGGFIVEE -----TT-TH HAATAPPKVV RGA----EEE RRHEEETTEH VVCCCCCGGG GSSAAFIDKK -----KK-VQ QTTSAPPKVV ---------- ---------- ---------- ---------- ---------- ---------- DGL----EEE RRHNNNRRNQ VVCCCCCXXX XXXXXXX--- ---------- -------QGG DGI----EEE RRHNNNKKAE VVCCCCCNNN NAAKKFFKDD -----EEFEA AKKVIKKDTT ---------- ---------- ---------- ---------- ---------- ---------- P------EEE RRWGGGNNNY SSTTTTTTTT TSSQQWIDAA ---------- -----QQAVV P------EEE RRWGGGAANY TTTTTTTTTT TSSQQWIDEE ---------- -----QQAVV PPKAVPPPLL VTTISSDKFY YLLSWWGGEV RRQIIISPPF KLTTGGKLGG GGGGGIFHHA DDKMVPPPLL VTTISSDRFY YVVSWWGGEL RRQIIITPPH QLAAGGRIGG GGGGGLYHHE GGGAVPPPLL VTTLSSDRFY YVVSWWGGEM RRQVVVSPPH NLAAGGSIGG GGGGGIARRA GGGAVPPPLL VTTLSSDRFY YVVSWWGGEM RRQVVVSPPR KLAAGGSIGG GGGGGIARRT GGGACPPPLL VTTLSSDKYY YVVAWWGGEM HHQVVVSPPM NLTTGGKIGG GGGGGIVKKT GGKAVPPPLL VTTLSSDRFY YVVSWWGGDL LLQVVVSPPF ELTTGGKIGG GGGGGIVSSA PPKAVPPPLL VTTLSSDRFY YVVSWWGGEL HHQVVVSPPF NLTTGGKIGG GGGGGIVRRA DDGAVPPPLL VTTLSSDRFY YVVSWWGGEL RRQVVVSPPF NHTTGGSLGG GGGGGIVRRA MMPEMPGGLL ITTLSSDRFY YFFSWWLGDI RRQIIISPPQ KLTTGGQLGG GGGGGSIVVG MMPEMPGGLL ITTLSSDRFY YFFSWWLGDI RRQIIISPPK KLTTGGQLGG GGGGGSIVVG MMPEMPGGLL ITTLSSDRFY YFFSWWLGDL RRQIIISPPQ RLTTGGQLGG GGGGGSIVVG MMPEMPGGLL ITTLSSDHFY YFFSWWLGDI RRQVVVSPPQ RLTTGGQLGG GGGGGSIVVD LLPEMPGGLL ITTLSSDRFY YFFSWWLGDL RRQIIISPPQ RLTTGGQLGG GGGGGSIVVG LLPEMPGGLL ITTLSSDRFY YFFSWWLGDL RRQIIISPPQ RL-------- ---------- LLPEMPGGLL ITT------- ---------- ---------- ---------- ---------- LLPEMPGGLL ITTLSSDRFY YFFSWWLGDL RRQIIISPPQ RLTTGGQLGG GGGGGSIVVG MMPEMPGGLL ITTLSSDRFY YFFNWWLGDM RRQIIISPPK RLVVGGQLGG GGGGGSIVVG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGVSLSNNEE FPPIFFDLLI IFFL------ ---------- ---------- ---------- AAPEMPGGLL ITTISSDRFY YFFSWWLGDI RRQIIITPPR NLVVGGQLGG GGGGGSILLG PPPEMPGGLL ITTISSDRFY YFFSWWLGDI RRQIIITTTR NLVVGGQLGG GGGGGSIQQG IIPEMPGGLL ITTISSDRFY YFFVWWLGDI RRQIIIELLK NLTTGGQVGG GGGGGLIQQG FFPEMPGGLL ITTISSDRFY YFFVWWLGDI RRQIIIEVVK NLTTGGQAGG GGGGGLIQQG IIPEMPGGLL ITTISSDRFY YFFVWWLGDI RRQIIIEPPK NLTTGGQVGG GGGGGLLQQG IIPEMPGGLL ITTISSDRFY YFFVWWLGDI RRQIIIEPPK NLTTGGQVGG GGGGGLLQQG IIPEMPGGLL ITTISSDRYY YLLVWWLGDI RRQIIIEPPA KLAAGGQAGG GGGGGLLQQG AAPEMPAALL ITTISSDRFY YVVSWWLGDI RRQIIISPPL KLNNSSQIGG GGGGGSVHHE AAPDMPAALL ITTISSDRFY YVVSWWLGDI RRQIIISPPK NLNNSSQIGG GGGGGSIHHE ---------- ---------- ---------- ---------- ---------- ---------- EEEMMGGGMM MTTISSDRYY YFFSWWRGDV RRQIIISRRA NLTTGGQLGG GGGGGAIQQD VVEDMGGGMM ISSISSDRFY YVVNWWRGDV RRQIIITPPE NLTTGGQLGG GGGGGAICCD ---------- ---------- ---------- ---------- ---------- ---------- GGPADIPPLL PVVIAADQTW WIINFFMGKT RRLIIISPPH KQIIYYEIDD DDRRRQVNN- GGPAKVPPLL PVVISSDSRW WVVNFFMGKT RRLIIISPPH HQVVYYEIGG GGAAAQVNN- DHPPPPP--- ---------- --AAKTTTGA PPQEISGRRV VTSSSLLYSS TNNNQQQYYP PHPPPPP--- ---------- --SSETTTGA PPQSVSGRRV ITSSSLLYSS SNNNQQQYYP PHPPPPP--- ---------- --NNTAAAGG PPQEISGRRV WTSSSLLYSS TDDDQQQYYP PHPPPPP--- ---------- --NNAAAAAG PPQEISGRRV WTSSSLLYSS TDDDQQQYYP PHPPPPP--- ---------- --NNTGGGYG PPQEISGKKV WTSSSLLYSS TEEEQQQYYP THPPPPP--- ---------- --KKANNNGG PPQEISGRRV FTSSSLLYGG APPPQQQYYP GHPPPPP--- ---------- --TTENNNGG PPQEISGRRV FTSSSLLYRR AEEEQQQYYP AHPPPPP--- ---------- --AAPNNNGG PPQEVSGRRV FSSSSLLYAA SEEEQQQYYP GSVVVVVVLE DDEELLTQPE LLKKRPPPGG PPQQLSGKKL ATSSSLLYSS DKKKQQQYY- GSVVVVVVLE DDEELLTQPE LLKKRPPPGG PPQQLSGKKL VTSSSLLYSS AKKKQQQYY- GPVVVVVVLE DDEELLKQPE LLKKKPPPGG PPQQLSGKKL VTSSSLLYSS AKKKQQQYY- GPVVVVVVLD DDEELLDQPE LLKKQAAAGG PPQQLSGKKL VTSSSLLYSS AKKKQQQYY- GPVVVVVVLE DDEELLKQPE LLKKRAAAGG PPQQLSGKKL ITSSSLLYSS AKKKQQQYY- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GPVVVVVVLE DDEELLKQPE LLKKRAAAGG PPQQLSGKKL ITSSSLLYSS AKKKQQQYY- GPVVVVVVLE DDEELLKQPE LLKKRPPPGG PPQQLSGKKI VTSSSLLYSS DKKKQQQYY- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GPVVVVVVLE DDDDLLEQPD VVKKKPPPGG PPQQLSGKKL VTSSSLLYSS KKKKQQQYY- GPVVVVVVLE DDEELLEQPD VVKKIPPPGG PPQQLSGKKI VTSSSLLYSS IKKKQQQYY- SPVVVVVAIG EEGGKKTQSD PPQQKRRRGG PPQQLTGKKL VTSSSLLFSS AKKKQQQYY- SPVVVVVAVK DDGGEETQSD PPQQKRRRGG PPQQLSGKKL VTSSSLLFSS AKKKQQQYY- SPVVVVVAVG EEGGNNSQFD PPKKSRRRGG PPQQLSGKKL ATSSSLLFSS ARRRQQQYY- SPVVVVVAVG EEGGNNTQFE PPKKSRRRGG PPQQLSGKKL ATSSSLLFSS AVVVSSSYY- SEVVVVVYVT EEDDKKEQYS PPKKRRRRGG PPQQLSGKKI VTSSSLLFSS REEEQQQYYG SNVVVVVVLE GGKK---PIE LLKKKEEEGG PPQQLSGKKL VTSSSLLYKK KDDDQQQYY- TTVVVVVVLE EEHHDD-EIP LLKKQEEEGG PPQQLSGKKL VSSSSLLYKK KDDDQQQYY- ---------- ---------- --------GG PPAQLSGKKL VTSSSFFYSS TKKKQQQYY- APRRRRRVLN DDEELLKAPE VVKKRLLLGG PPQQLSGRRL VSSSSLLFSS PKKKQQQYY- LPNNNNNIVK DDEELLKRPP RRKKREEEGG PPQQLSGKKL VSSSSLLYSS PKKKQQQYY- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---SQSGKKV FSSSSLLLAA N--------- ---------- ---------- ---------- ---SSSGQQL YTSSSLLLAA N--------- GLLGGWN--- -----SSSSG LDDKEFVVVF FGE------- RRSHQVRRLS GSSSSSSYCC GLLGGWN--- -----EEEEG LEEKEFVVVF FGR------- RRAHQVRRLW GSSTTTSFCC GVVAAAG--- -----DDDDG LAADDYVVVF FPDGGG---- RRAHQIRRLE GSSTTTSFCC GVVGGVG--- -----NNNNG LDDKDYVVVF FPDGGG---- RRAHQIRRLE GSSTTTSFCC DRRAAAG--- -----NNNNG LDDKDFVVVF FPAGGG---- RRSHQIRRLE GSSTTTSFCC GIIGGWG--- -----NNNNG IDDPKFLLLW WPKGGG---- RRPHQVRRLQ GSSSSSSYCC GIIGGWN--- -----DDDDG MDDPNFVVVF FGE------- RRVHQIRRLQ GSSSSSSYCC GIIGGWD--- -----GGGGG LDDPGFTTTV VGDGGG---- RRPHQIRRLE GSSSSSSYCC DLLRREVDVV VVDDDNNNNG LNNPNFVVVF FGKEEEPLGG LLAHELRRYP GSSSSSIWII NLLRREIDVV VVDDDNNNNG LNNPNFVVVF FGKEEEPLGG LLAHELRRYP GSSSSSIWII DLLRREIDVV VVDDDKKKKG LNNPNFVVVF FGKEEEPLGG LLAHELRRYP GSSSSSIWLL DLLRREIDVV VVDDDKKKKG LNNPNFVVVF FGKEEEPLGG LLAHELRRYP GSSSSSIWLL DLLRREVDVV VVDDDKKKKG LNNPNFVVVF FGKEEEPLGG LLAHELRRYP GSSSSSIWII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DLLRREVDVV VVDDDKKKKG LNNPNFVVVF FGKEEEPLGG LLAHELRRYP GSSSSSIWII DLLRREIDVV VVDDDKKKKG LNNPNFVVVF FGKEEEPLGG LLAHEIRRYP GTTSSSIWLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DMMKKEIDVV VVDDDKKKKG LNNPNFVVVF FGKEEEPGGG LLAHELRRYP GSSSSSIWVV DLLKKEIDVV VVDDDKKKKG LNNPNFVVVF FGKEEEPDGG LLAHEIRRYP GTTSSSIWII GLLEEKIDVV VVDDDKKKKG LNNPNFVVVF FGAEEEPDGG LLAHEMRRYP GTTSSSIWII KLLEEQIDVV VVDDDNNNNG LNNPNFVVVF FGAEEEPDGG LLAHEMRRYP GTTSSSIWII ELLDDKIDVV VVDDDKKKKG LNNPNFVVVF FGDEEEPEGG LLAHEMRRYP GTTSSSIWII EIIEEKIDGG GGDDDKKKKG LNNPDFVVVF FGDEEEPDGG LLAHEMRRYP GTTSSSIWII DLLKKKIDVV VVDDDKKKKG LNNPNFVVVF FGAEEEPEGG LLAHEMRRYP GTTSSSIWII EHHKKSVNII IIDDDSSSSG MNNRDFIIIF FGKIIIEGGG LLAHEMRRYP GTTSSSIWII ENNRRSIDVV VVDDDTTTTG MNNKNFIIIF FGKVVVPGGG LLAHEMRRYP GTTSSSIWII NVVKKEIDVV VVDDDKKKKG LNNKNFVVVF FGKEEEPNGG LLAHDIRRFP CTTSSSILAA EMMAAALDII IIDDDNNNNG MNNENFVVVF FGGEEEPYGG LLPHEMRR-- ---------- KMMSSQIDVV VVDDDNNNNG INNEDFVVVF FANEEEPYGG LLPHEMRRYP GTTSSSIWLL ---------- ---------- ---------- ---------- ---------- ---------- ---KKKYLKK KKAAAWWWWD KVVEDFVVVF FYELLLGLGG RRAHIMRRFG SYYSSS---- ---KKKFLKK KKLLLWWWWD KKKEQFIIIF FYAEEEKLGG RRPHQMRRFG AYYAAAPAGG YYYY--- YYYY--- YYYYKR- YYYY--- YYYY--- YYYY--- FFFF--- YYYY--- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AAAA--- ------- ------- DDDDLVQ 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNAKKAAKQQ PPPEAATRRT TAAAVGGLTA AARADDAASS LPTAQLLSSL GSSVVRRRII gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KAYQATTTFF SSSSAILLSP RSSSSKKGGR KRPPSSAAAK KQQVPSSSQQ AQWWWLLPPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AER ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----GLLGKE ---------- ---------- ---------- ---------- ---------- --LLNSSQGC ---------- ---------- ---------- ---------- ---------- ---------- --MARPPPTT LLPPPLRRPP HPPPPLLAAP APPPLLVPPY YRRTNVVVPP PPCCHAARHS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMKRR ---------- ---------- ---------- ---------- ---------- -----MMKRF ---------- --------AK KTFFPSSMMM MKKKPPELLY YVACLYYYYG GIIINNRAFA ---------- ---------K KTFFPTTDDM MRRRPPEIIY YVAALYYYYG GVVVNNAPFA ---------- ---------R RTFFASSLLM MQQQPAEFFY YTLLLSSSSD S-----RPAA ---------- ---------R RTFFASSLLM MEEEPAEFFY YTLLLSSSSD S-----KPAA ---------- ---------R RTFFPSSLLM MEEEPVELLF FTLMLSSSSD S-----KPGA ---------- ---------K KSFFPSSLLA AKKKPPEIIY YVAMFDDDDE K-----QPAA ---------- ---------R RTFFPSSMMV VKKKPAELLY YVVRLNNNNM NGGG--KPAC ---------- ---------R RTFFPSSMMM MQQQPRELLY YVALLDDDDG E-----RPAG ---------- -------AK- -GYYTPPAAK K---PREIIY YLPCIYYYYN GTTTEEAPYA ---------- ---------- ---------M M---PREIIY YLPCIYYYYN GIIIEEAPYA KKHGAIRGLL GGGGAAASQ- -GYYSPPAAK K---PREIIY YLPCIYYYYN GIIIEEAPYA ---------- ---------- ---------K K---PREIIY YLPCIYYYYN GIIIEEAPYA ---------- -------AK- -GYYTPPAAK K---PREIIY YLPCIYYYYN GTTTEEAPYA AAEGFQQPMR IIIISSSAK- -GYYTPPAAK K---PREIIY YLPCIYYYYN GTTTEEAPYA ---------- -------AK- -GYYTPPAAK K--------- ---------- -TTTEEAPYA ---------- -------AK- -GYYTPPAAK K---PREIIY YLPCIYYYYN GTTTEEAPYA EEPGTPSGQL QQQQDDDAK- -GYYTPPAAK K---PREIIY YLPCIYYYYN GTTTEEAPYA LLGFQTTYCT VVVVTTTPK- -GYYTPPAAK K---PREIIY YLPCIYYYYN GTTTEEAPYA ---------- -------AK- -GYYTPPAAK K---PREIIY YLPCIYYYYN GTTTEEAPYA LLVLHEAVET AAAAAAAGTA AGYYTPPAAE EKKKPRELLY YVTCVYYYYG GIIINNKLYA ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MK- -GYYSPPAAK K---PREIIY YLPCIYYYYS GIIINNKPYA -----ADHGV NNNNKKKSVK KGYYSPPSSS S---PRELLY YVTAVYYYYG GIIIEEKPYA -----GQHAV SSSSKKKNQK KGYYSPPAAS S---PRELLY YVTAVYYYYG GIIIEEKPYA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------V VGYYTPPAAS S---PSELLY YVTAVYYYYG GIIIDDKPYA ---------M AAAAAAAGAA AGYYTPPAAE EKKKPRELLY YVTCVYYYYG GIIINNKPYG ---------- SSSSNNNGK- -GYYSPPAAK K---PREVVF FVTAP----- AAAADDGPAF ---------- PPPP---PK- -GYYSPPAAK K---PREVVF FVTAP----- ARRRDDGPAF ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------SK KGYYTPPAAR RNNNPVELLY YVVCVQQQQN DEEEEEHGYA ---------- ---------- ---------R RSSSPRELLY YTVTVQQQQN DEEEPPHGYS ---------- ---------- -GLLT--III ISSSDDRLLF FSNWLHHHHD RQQQYYDIDK EEFG---ALA GGGGAAAAGA AETTQSSMMK KIIIGQEFFY YVWTLGGGGE MGGGDDEQKV IIVSPHRALV GGGGAAAAAV VETTASSMMK KIIIGQEYYY YVWTLGGGGE VGGGDDEQKV VVDNNNSETT YYSKKKKVVH HVVVELPPYI DELLHHHFFN NCSSSSSAAC --PNNNGKPP VVDDDDSPTT YYGKKKKIIY YLLLDLPPYI DELLHHHFFN NCSSSSSAAC --PNNNAKPP IIDKKKSSTT YYGKKKKVVH HVVVTMPPNT DEFFHHHFFN NCSSSSSSSS --PLLLTHAA IIDKKKSPTT YYGQQQQVVH HVVVTMPPNK DEFFHHHFFN NCSSSSSAAS --PLLLAHAA VVDDDDSEKK FFGQQQQVVH HLLLIMPPNK DEFFHHHFFN NCSSSSSAAS --PLLLTHAA VVDDDDSPRR YYASSSSVVG GVVVAMPPHA DELLHHHFFN NCSSSSSCCC --PNNNAHPP VVDDDDSSTT FFGQQQQVVG GTTTDMPPYT GELLHHHFFN NCSSSSSMMC --PNNNAHPP LLDDDDSGTT YYAQQQQVVG GVVVEMPPNA DELLHHHFFN NCSSSSAAAC --PYYYAHPP VVDDDDSPQQ YYSQQQQIIH HLLLPMPPYL DELLHHHSSN NCSSSSSCC- ------FDSS VVDDDDSPHH YYSQQQQIIH HLLLPMPPHL DELLHHHSSN NCSSSSSCC- ------FDSS VVDDDDSPQQ YYCQQQQIIH HLLLPMPPNL DELLHHHSSN NCSSSSSCC- ------FDSS VVDDDDSPQQ YYCQQQQIIH HLLLPMPPHL DELLHHHSSN NCSSSSSCC- ------YDII VVDDDDSPQQ YYCQQQQIIH HLLLPMPPNL DELLHHHSSN NCSSSSSCC- ------FDSS VVDDDDSPQQ YYCQQQQIIE E--------- ---------- ---------- ---------- VVDDDDSPQQ YYCQQQQIIH HLLLPMPPNL DELLHHHSSN NCSSSSSCC- ------FDSS VVDDDDSPQQ YYCQQQQIIH HLLLPMPPNL DELLHHHSSN NCSSSSSCC- ------FDSS VVDDDDSPQQ YYSQQQQIIH HLLLPMPPYL DELLHHHSSN NCSSSSSCC- ------FDSS VVDDDDSPQQ YYCQQQQIIH HLLLPMPPNL DELLHHHSSN NCSSSSSCC- ------FDSS VVDDDDSPQQ YYCQQQQIIH HLLLPMPPNL DELLHHHSSN NCSSSSSCC- ------FDSS VVDDDDSPTT YYSQQQQIIH HLLLPVIIHI DKLLHHHSSN NCSSSSSCC- ------HDPP ---------- ---------- -----MPPNT DELLHHHSSN NCSSSSSCC- ------YDAA VVDDDDSPSS YYSQQQQIIH HLLLPMPPNV DELLHHHSSN NCSSSSSCC- ------YDSS VVDDDDSPTT YYSKKKKIIH HLLLPVPPYV DELLHHHTTN NCSSSSSCC- ------HDPP VVDDDDSPTT YYSKKKKIIH HLLLPVPPYV DELLHHHTTN NCSSSSSCC- ------HDPP ---------- ---------- -----MPPFV DELLHHHSSN NCSSSSSCC- ------HDAA VVDDDDSPSS YYSSSSSIIH HLLLPMPPFV DELLHHHSSN NCSSSSSCC- ------HDAA VVDDDDSPTT YYSQQQQIIH HLLLPVTTHV DELLHHHSSN NCSSSSSCC- ------HDPP VVDNNNSDTT FFCQQQQIIS SVVVDVPPHI DEVVHHHTTN NCSSSSSCC- ------HKPP VVNNNNSETT FFCQQQQIIS SVVVDVPPNI DEVVHHHTTN NCSSSSSCC- ------HKPP ---------- ---------- ---------- ---------- ---------- ---------- VVDDDDSPTT YYCQQQQIIH HTTTYTNNSK NELLHHHSSN NCSSSSSCCF VVP---GKEE VVDDDDSPTT YYCQQQQVVH HTTTFTNNRK DELLHHHSSN NCSSSSSCCY VVDEEESKTT PPRVVVVFLL GGGSSSSLLK KGGGPVKKVL DKEELLLSST TRIIIILKK- -------KRR IIDRRRSATT RRGQQQQIIN NVVVSVGGG- NEAAHHHGGS S--------- ---------- VVDNNNSPQQ YYGKKKKVVN NLLLSVGGG- NEAAHHHSST T--------- ---------- IIEEFLIIIP PLSSRRIIDD KKNNPPRPII IIKVIEEEPE VKSSSSSHHH CDAIINE--E LLEEYLIIIP PLSSRRIIDD KKDDKKRPVV VAKIVEEEPV AVTTTTTHHH CDAIIGP--D LLEEFLIIIP PLSSRRIVDD KKHHPPTAII IHKIIEEEPE ILTTTTSHHH CEGIVGAKKD IIEEYLIIIP PLSSRRIIDD KKDDPPTAII IHKIIEEEPE VFTTTTSHHH CDGIVGGKKD LLEEYLIIIP PISSRRIIDD KKEEPPLAII IHKIIEEEPE VFTTTTSHHH CEGIVGGEED MMEEYLVVVP PLSSRRIIDD KKDDPPLPLL LAKVIEEEPT LATTTTSHHH CGGIVNA--E VVEEYLVVVP PISSHHIIDD KKDDPPTPVV VVKVIDDDPE LATTTTAHHH CDGIISP--E VVEEYLIIIP PISSRRIIDD KKDDPPRPII IVKVIEEEPE LHTTTTSHHH CDGVVSP--E KKSSKLIIIP PLSSRRIVDD GGEEPPRPLL LHKVIEEEAE IQCCCCSHHH CSGEMGD--L KKSSKLIIIP PISSRRIVDD GGEEPPRPLL LHKVIEEEPE IHCCCCGHHH CSGEMGD--P KKSSKLMMMP PLSSRRIVDD GGDDPPRPLL LHKVIEEEAD IHCCCCGHHH CSGEMGD--S KKAAKLVVVP PLSSRRIVDD GGEEPPRPLL LHKVIEEEPD IHCCCCGHHH CSGEMGD--P KKSSKLVVVP PLSSRRIVDD GGEEPPRPLL LHKVIEEEPD IHCCCCAHHH CSGEMGD--V ---------- ---------- ---------- --------PD IHCCCCAHHH CSGEMGD--V KKSSKLVVVP PLSSRRIVDD GGEEPPRPLL LHKVIEEEPD IHCCCCAHHH CSGEMGD--V KKSSKLVVVP PLSSRRIVDD GGEEPPRPLL LHKVIEEEPD IHCCCCAHHH CSGEMGD--V KKSSKLVVVP PFSSRRIVDD GGEEPPRPLL LHKVIEEEAD IHCCCCGHHH CTGEMGD--P KKSSKLVVVP PL-------- ---------- ---------- ---------- ---------- KKSSKLVVVP PLSSRRIVDD GGEEPPRPLL LHKVIEEEPD IHCCCCAHHH CSGEMGD--V AAKKFLIIIP PLSGRRVVDD AADDPPRPLL LHKVVEEESD IAIIIIGHHH CSGDMGD--K KKVVKLIIIP PLSSRRIVDD GGDDPPRPII IHKTVEEEPE VFCCCCAHHH CCGEMGD--P KKVVKLIIIP PLSSRRIVDD GGDDPPRPII IHKTVEEEPE VFCCCCAHHH CCGEMGD--P AAEEFLIIIP PLSGRRIVDD KKNNPPRPLL LHKVVDDDPD IITTTTAHHH CSGEMGD--K AAQQFLIIIP PISGRRVVDD KKNNPPRPLL LHKVVEEEPD ISTTTTAHHH CSGEMGD--K AADDYLVVVP PLSGRRIADD KKNNPPRPLL LYKYVDDDPE IATTTTAHHH CSGELGD--E VVDDYLVVVP PLSGRRIADD KKNNPPRPLL LYKYVDDDPE IATTTTAHHH C-GELGD--E AASSFLIIIP PLSGRRVVDD LLDDPPRPLL LHKVVEEEAD IATTTTGHHH CSGEMGD--K EEKKHLIIIP PLSDRRIINN EEEE--RILL LEHTIEEEPK LHNNNNSHHH CDGNMGE--A EEKKHLIIIP PLSDRRIVNN EEEE--RILL LQHTIEEEPK LHNNNNSHHH CDGNMGE--A -----MVVVR RLSGVVEKFF GG-------- ---------- ---------- ---------- PPTTRLVVVP PLSDRRIVDD GGDDPPRPLL LAKVIEEEGD VLAAAATHHH CNGNMGD--A PPKKRLVVVP PLSDFFIIDD VVDDPPRPII IVKTIDDDGD VLHHHHTHHH CNGNMGD--A QQGGQMLLLL LLGKRRLVTT LLSSAAWKFF FYP------D LILLLLAHDD YNTAKNE--S --DDFFWWWG GLTNRRIIDD HHDDPPSPLL LHKTIDDDTF VKGGGGVHFF AGSMIND--D --DDYLWWWG GLTSKKIVDD HHDDPPAPLL LSKTITTTDF VEGGGGVHYY AGRMINN--K GGGIHHHHFE ELLKKEEDRR D--------- --LLDFFWNL -NEEVVSWVV V--TIDKKLL GGGIHHHHFE EIIRREEYRR P--------- --FFDFFWNL -SGGVVTWVV V--CFESSLL GGPICCCCFD DLLRREEDRR P--------- --KKDFFWNL -RDDYYSWLL L--QFNVVPP GGPVCCCCFE ELLRREEDRR P--------- --LLDFFWNL -RDDYYTWLL L--QFNVVPP GGPICCCCFE ELLRREEDRR E--------- --KKDFFWNL -RDDYYSWLL L--QFNVVPP GGGIAAAAFE ELLRREEERR P--------- --FFDGGWHL -YDDTTTWTT T--MVDVVPP GGGIHHHHLE ELLRREEDRR D--------- --LLDFFWHL -YDDTTTWTT T--MVSLLGG GGGVHHHHFD DLLRREEERR P--------- --LLDFFWHL -YDDTTTWTT T--MIGDDPP GGGFGGGGFE EKKTTEEPGG A--------- --MMDFFYQP -HNNVVSWAA A--VFDPPAA GGGFGGGGFE EKKTTEEPGG E--------- --MMDFFYQP -HNNIISWAA A--VFDPPAA GGGFGGGGFE EKKTTEEPGG A--------- --MMDFFYQP -HNNVVSWAA A--VFDPPAA GGGFGGGGFE EKKTTEEPGG A--------- --LLDFFYQP -HNNVVSWAA A--VLDPPAA GGGFGGGGFE EKKTTEEPGG A--------- --SSDFFYQP -HNNVVSWAA A--VLDPPAA GGGFGGGGFE EKKTTEEPGG A--------- --LLDFFYQP -HNNVVSWAA A--VLDPPAA GGGFGGGGFE EKKTTEEPGG A--------- --LLDFFYQP -HNNVVSWAA A--VLDPPAA GGGFGGGGFE EKKTTEEPGG A--------- --LLDFFYQP -HNNVVSWAA A--VLDPPAA GGGFGGGGFE EKKTTEEPGG S--------- --MMDFFYQP -HNNVVSWAA A--VVNPPAA ---------- ---------- ---------- ---------- ---------- ---------- GGDSPPPPLE ESS------- ---------- ---------- -------SHH H--LRTDDYY AAGGDDDDFN NKKRRSSRLL P--------- --KKTHHYEN YWGGLLSQCC C--FYTLLMM GGGFGGGGFE EKKNNEEEGG A--------- --FFDFFYQP -HNNVVSWAA A--AFLMMEE GGGFGGGGFE EKKNNEEEGG S--------- --FFDFFYQP -HNNVVSWAA A--AFLMMEE AAGGDDDDFN NKKRREEPGG S--------- --FFDFFYQP -HNNTTSWAA A--AFKLLQQ AAGGDDDDFN NKKRREEPGG S--------- --FFDFFYQP -HNNTTSWAA A--AFQLLQQ AAGGDDDDFN NKKRREEPGG S--------- --FFDFFYQP -HKKTTSWAA A--AFKLLQQ AAGGDDDDFN NKKRREEPDD S--------- --YYHFFYQP -HKKTTSWAA A--AFKLLQQ AAGGDDDDFN NKKRREEPGG S--------- --FFDYYYQP -HKKTTSWAA A--AFTLLQQ PPGFGGGGFE EKKTTPPDEE T--------- --FFDFFYQP -RNNVVSWSS S--HIKPPAA PPGFGGGGFE EKKTTPPDGG V--------- --FFDFFYQP -RNNIISWSS S--HIKPPAA ---------- ---------- ---------- ---------- ------SRGG G--TVRLLKK AAGDDDDDFE EVVTTSSGDD K--------- --CCDYYYQP -FNNVVAWAA A--LFRPPTT AAGDDDDDFN NIITTTTGDD K--------- --CCDFFYQP -FDDVVSWAA A--KWRNNVV PPLGKKKKNG GSSKKEESQQ E--------- --LLSNNNNG -REEKKSPEE E--MAESSFF GGTLDDDDEY YAAYYMMTAA DGAAAVDADG GGYYDIIALI -KNNVVTFGG GNNMMFLLQQ GGTLNNNNEY YAAHHIITDD DGAKKT-KDG GGYYDVVALP -KNNLLTFGG GNNMMFLLAA HHHHHLLLKK KDGNNNRIHF FFDLRRRKKR RKRRIIILTN RAALL----- --PHPTKLLF CCCCCLLLKK KEGNNNKLHV VVDLAAAKKR RRHHLLLIDH RVVLL----- --PHPTKLLF DDDDDLLLLL LAGHHHRLHF FFDLRRRAAR RRNNVVVIDH QAALL----- --PHPVREEF DDDDDLLLLL LSGHHHRLHF FFDLRRRAAR RRNNVVVIDH QAALL----- --PHPVREEF DDDDDLLLLL LSGHHHKIHF FFKLRRRDDR RKNNVVVIDH QAALL----- --PHPSKDDF IIIIILLLLL LGGRRRRLHF FFDLTTTRRR RRHHLLLIDH QVVFF----- --PHPTKAAF EEEEELLLLL LAGHHHRLHV VVDLYYYRRR RRHHLLLLDY QAALL----- --PHPTKAAF IIIIILLLLL LNGRRRRLHI IIDLRRRRRR RRHHLLLLDH QVVLL----- --PHPARTTF VVVVVEEEAA A-GSSSRIFV VVDWQQQRRH HEIIIIILQD GIIPP----- LLFHPSATTF VVVVVEEEAA A-GSSSHIHV VVDWQQQRRH HEIIIIILQD GIIPP----- LLFHPDATTF VVVVVEEEAA A-GSSSHLHV VVDWQQQRRH HEIIIIILTD GIIPP----- LLFHPDAAAF VVVVVKKKAA A-GSSSHLYV VVDWQQQRRR REIIVVVLPD GIIPP----- LLFHPDAAAF VVVVVEEEAA A-GSSSHLYV VVDWQQQHHH HEIIVVVLSD GIIPP----- LLFHPDAAAF VVVVVEEEAA A-GSSSHLYV VVDWQQQRRH HEIIVVVLSD GIIPP----- LLFHPDAAAF VVVVVEEEAA A-GSSSHLYV VVDWQQQRRH HEIIVVVLSD GIIPP----- LLFHPDAAAF VVVVVEEEAA A-GSSSHLYV VVDWQQQRRH HEIIVVVLSD GIIPP----- LLFHPDAAAF VVVVVEEEAA A-GKKKHLHV VVDWQQQRRH HEIIVVVLLD GIIPP----- LLFHPAASSF ---------- ---------- ---------- ---------- ---------- ---------- AAAAASSSAA A-AGGGIT-- ---------- ---------- ---------- ---------- LLLLLTTTAA A-HVVVISCL LLNYIIIMMR RVIIDDDLPD QGGAANNPPP LLSHKNINNY VVVVVQQQAA A-GHHHSLNV VVDWTTTEEH HRRRIIIIDD GIIPP----- LLFHPDAAAL VVVVVQQQAA A-GHHHSLNV VVDWTTTEEH HRLLVVVIDD GIIPP----- LLFHPDADDL VVVVVAAADD D-GRRRHLTC CCQLAAARRG GELLRRRLDT GLLPP----- LLFHPAKDDF VVVVVAAADD D-GRRRHLHV VVSWPPPGGG GEIIKKKLDK GLLPP----- LLFHPAKDDF VVVVVAAADD D-GSSSHLHV VVSWPPPGGG GEMMKKKIDT GLLPP----- LLFHPSKDDY VVVVVAAADD D-GSSSHLHV VVSWPPPGGG GEIIKKKIDT GLLPP----- LLFHPSKDDF VVVVVQQQDD D-GRRRHLHV VVDWPPPGGG GELLKKKLDT GLLPP----- LLFHPSKDDY VVVVVGGGEE E-GNNNSVHI IIEWDDDSSK KKYYLLLIDL GLLPP----- LLFHPTSEEF VVVVVPPPEE E-GNNNSVHI IIEWDDDTTK KKHHLLLIDR GLLPP----- LLFHPTSEEF QQQQQPPPEE E-IKKKCKRV VV-------- ---------- ---------- ---------- CCCCCDDDDD DRGCCCRLNF FFRWQQQEER RELLFFFIDD GTTPP----- LLFHPRENNY LLLLLEEEDD DMGCCCRLNF FFKWSSSTTQ QTLLYYYIDD GTTPP----- LLFHPKKAAF KKKKKKKKTT TGPQQQHVAE EEL------- ---------- ---------- ---------- AAAAAEEEAA AMGNNNTIVQ QQDLHHHTTR RQPPKKKFNP ---------- LLFWSNANNF PPPPPEEEAA AMGNNNTVVT TTDLHHHTTK KQPPKKKFDP ---------- LLCWEAHNNF INMVVSSKKD LLSSIIIIIW LFFYY-DGGK KKKNNAAKVI EEPPAAPLLE GG-NNNPPEE VNVVLNNKKD LLSSIIIIIW LFFYY-DGGK KKKQQAARVI DDEEAAPFFE GG-PPPPPPP VGVVVDDTTN LLGSIIIIIW TWWRR-GGGK KKKHHVVKTA TTPPAAPAAT AADEEEPPPP VGVVVDDTTN LLASIIIIIW TWWRR-GGGK KKKHHAAKTA TTPPPPPAAP KKEKKKPPPP CGVVVDDTTN LLGAIIIIIF TWWQQKDGGT TTTEEAAKTI TTDDPPPAAD AADDDDPPDD VNCVISSKKD LLSSIIIIIW TYYRR-KDDK KKKAAVVKVI EEPPAAAAAD PPDQQQPPPP MNCVVSSKKD LLASIIIIIW LYYRR-NGGS SSSHHLLKVI DDPPAAPAAS EEDQQQPPPP VGVVVSSEED LLASVVVVVW LHHRR-NGGS SSSGGIIKVI EEPPAAPAAE PPDQQQPPPP VGCALSSNNI QQFYKKKKKN EGG------- ---------T WWVVEEVIIQ VVPSSSKKVV VGCALSSNNI QQFYKKKKKN EGG------- ---------T WWVVEEVIIQ VVPSSSKKVV VGCALSSTTI QQFYKKKKKN QGG------- ---------T WWVVEEVIIQ VVPPPPKKVV VGCALSSTTI QQFFKKKKKN EGG------- ---------T WWAAQQVIIQ VVPPPPKKVV VGCALSSTTI QQFYKKKKKN EGG------- ---------T WWVVEEVIIQ VVPPPPKKVV VGCALSSTTI QQFYKKKKKN EGG------- ---------T WWVVEEVIIQ VVPPPPKKVV VGCALSSTTI QQFYKKKKKN EGG------- ---------T WWVVEEVIIQ VVPPPPKKVV VGCALSSTTI QQFYKKKKKN EGG------- ---------T WWVVEEVIIQ VVPPPPKKVV VGCALSSTTI QQFYKKKKKN EGG------- ---------T WWVVEEVIIE VVPPPPKKVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DVVEVSSSSG RRGSDDDDDP DYY------- ---------A VVLLKKKLLD LLYYYYVVVV VGCALSSTTV FFFYKKKKKE KGG------- ---------K WWAAEEVIIK VVPSSSKKVV VGCALSSSSI FFFYKKKKKE KGG------- ---------K WWAAEEVIIQ VVPSSSKKVV VGSALSSNNM IIFFKKKKKT QGG------- ---------S WWHHEEAIIP VVKPPPKKVV VGSALTTNNM IIFFKKKKKT QGG------- ---------S WWHHEEVIIS VVEPPPKKVV VGSALSSNNM IIFFKKKKKN SDD------- ---------T WWYYEEVIIS VVKPPPKKVV VGSALSSNNM IIFFKKKKKN SEE------- ---------T WWHHEEVIIS VVKPPPKKVV VGCALTTNNM VVFFKKKKKT AGG------- ---------S WWHHEEAIIS IIKPPPKKVV VGCALGGGGI FFIHPPPPPV ENNSS----- -------T-T HHAATTVAAF IIPSSSKKVV VGCALGGAAI FFIHPPPPPD ENNPP----- -------K-V QQAASSVAAT IIPSSSKKVV ---------- ---------- ---------- ---------- ---------- ---------- VGCAFXXXXX XXXX------ ---------- ---------- ---------- ------QQGG VGCALNNKKV FFFKKKKKKK SSSDD----- -------EFE AAKKVVDIIP GGKLLLDDTT ---------- ---------- ---------- ---------- ---------- ---------- STTALTTQQL WWIYEEEEED DGG------- ---------- ---------E WWQAAAAAVV TSTALTTQQL WWIYEEEEED GGG------- ---------- ---------E WWQAAAAAVV LLKPKAVVVT TDDDIIDILL DDDKKKFFFL LLYSLLGGGG GRYDIINKVV LLTGGVKLLL LLKDKMVVVT TDDDIIDILL DDDRRRFFFL LLYSLLGGGG GRYDIINQRR LLAGGVKIII LLQGGAVVVT TDDDIIDLLL DDDRRRFFFL LLYSCCGGGG GRYDVVDNVV LLAGGVRIII LLQGGAVVVT TDDDIIDLMM DDDRRRFFFL LLYSCCGGGG GRYDVVDKKK LLAGGVHIII LLKGGACVVT TDDDIIDLLL DDDKKKYYYL LLYACCGGGG GHYDVVDNVV LLTGGVEIII LLKGKAVVVT TDDDIIDLMM DDDRRRFFFL LLYSCCGGGG GLYDVVDEKK LLTGGVRIII LLKPKAVVVT TDDDIINLVV DDDRRRFFFL LLYSCCGGGG GHYDVVDNRR LLTGGVQIII LLKDGAVVVT TDDDIINLLL DDDRRRFFFL LLYSCCGGGG GRYDVVDNRR HHTGGVRLLL GGWMPEMIIT TDDDIILLLL DDDRRRFFFL LLYSNNGGGG GRYDIINKRR LLTGGIFLLL GGWMPEMIIT TDDDIILLLL DDDRRRFFFL LLYSNNGGGG GRYDIINKRR LLTGGIFLLL GGWMPEMIIT TDDDIILLLL DDDRRRFFFL LLYSNNGGGG GRYDIIDRRR LLTGGLFLLL GGWMPEMIIT TDDDIILLLL DDDHHHFFFL LLYSNNGGGG GRYDVVDRRR LLTGGLFLLL GGWLPEMIIT TDDDIILLLL DDDRRRFFFL LLYSNNGGGG GRYDIIDRRR LLTGGLFLLL GGWLPEMIIT TDDDIILLLL DDDRRRFFFL LLYSNNGGGG GRYDIIDRRR LL-------- GGWLPEMIIT T--------- ---------- ---------- ---------- ---------- GGWLPEMIIT TDDDIILLLL DDDRRRFFFL LLYSNNGGGG GRYDIIDRRR LLTGGLFLLL GGWMPEMIIT TDDDIILLLL DDDRRRFFFL LLYNNNGGGG GRYDIIDRRR LLVGGIFLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKFGVSLFFP PPPPAAWIFF SDDLLLLLLI IIILSS---- ---------- ---------- GGWAPEMIIT TDDDIILILL DDDRRRFFFL LLYSNNGGGG GRYDIIDNKK LLVGGIFLLL GGWPPEMIIT TDDDIILILL DDDRRRFFFL LLYSNNGGGG GRYDIIDNKK LLVGGIFLLL NNWIPEMIIT TDDDFFLILL DDDRRRFFFL LLYVNNGGGG GRYNIIDNVV LLTGGLWVVV NNWFPEMIIT TDDDFFLILL DDDRRRFFFL LLYVNNGGGG GRYNIIDNKK LLTGGVWAAA NNWIPEMIIT TDDDFFLILL DDDRRRFFFL LLYVNNGGGG GRYNIIDNVV LLTGGIWVVV NNWIPEMIIT TDDDFFLILL DDDRRRFFFI IIYVNNGGGG GRYNIIDNVV LLTGGIWVVV NNWIPEMIIT TDDDFFVILL DDDRRRYYYL LLYVNNGGGG GRYNIIDKVV LLAGGVWAAA GGWAPEMIIT TDDDIILIMM DDDRRRFFFL LLYSCCGGGG GRYDIIDKKK LLNSSVYIII NNWAPDMIIT TDDDIILIMM DDDRRRFFFL LLYSCCGGGG GRYDIIDNKK LLNSSVFIII ---------- ---------- ---------- ---------- ---------- ---------- NNGEEMMMMT TDDDIILILL DDDRRRYYYL LLYSNNGGGG GRYDIIDNRR LLTGGVFLLL SSGVEDMIIS SDDDIIIILL DDDRRRFFFL LLYNCCGGGG GRYDIIDNKK LLTGGLFLLL ---------- ---------- ---------- ---------- ---------- ---------- DDIGPADPPV VDDDIISIAA DDDQQQTTTL LLWNSSGGGG GRFDIIDKFF QQIYYKVIII DDIGPAKPPV VDDDIISINN DDDSSSRRRL LLWNTTGGGG GRFDIIDHRR QQVYYKTIII LGGIIFHRRR DPP------- ---------- ---AALTTGM MLLLESRRDD GVVYTTTNSL IGGLLYHRRR PPP------- ---------- ---SSATTGM MIIISSRRDD GVVYTTTNSL IGGIIARRRR PPP------- ---------- ---NNFAAGM MVVVESRRDD GVVYTTTNSL IGGIIARRRR PPP------- ---------- ---NNFAAAM MVVVESRRDD GVVYTTTNSL IGGIIVKKKK PPP------- ---------- ---NNFGGYM MVVVESRRDD GVVYTTTNSL IGGIIVSRRR TPPGG----- ---------- --AKKLNNGM MVVVESRRDD GVVYTTTNSL IGGIIVRRRR GPP------- ---------- --ATTLNNGM MVVVESRRDD GVVYTTTNSL LGGIIVRKKK APP------- ---------- ---AALNNGM MVVVESRRDD GVVYSSSNSL LGGSSIVRRR GVVQQVVLED QEELLTCCQP LVVKKIPPGM MIIIQSLLDD GLLYTTTTSL LGGSSIVKKK GVVQQVVLED QEELLTCCQP LVVKKVPPGM MIIIQSLLDD GLLYTTTTSL LGGSSIVKKK GVVQQVVLED QEELLKSSQP LVVKKVPPGM MIIIQSLLDD GLLYTTTTSL LGGSSIVKKK GVVQQVVLDD QEELLDSSQP LVVKKVAAGM MIIIQSLLDD GLLYTTTTSL LGGSSIVKKK GVVQQVVLED QEELLKSSQP LVVKKVAAGM MIIIQSLLDD GLLYTTTTSL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGGSSIVKKK GVVQQVVLED EEELLKSSQP LVVKKVAAGM MIIIQSLLDD GLLYTTTTSL LGGSSIVKKK GVVQQVVLED QEELLKSSQP LVVKKVPPGM MIIIQSLLDD GIIYTTTTSL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGGSSILRRR GVVTTVVLED KDDLLECCQP VIVKKVPPGM MIIIQSLLDD GLLYTTTNSL LGGSSIQRRR GVVTTVVLED KEELLECCQP VTVKKIPPGM MIIIQSLLDD GIIYTTTSSL VGGLLIQKKK SVVAAAAIGE DGGKKTWWQS PEIQQLRRGM MIIIQTLLDD GLLYTTTNSL AGGLLIQKKK SVVVVAAVKD DGGEETWWQS PEIQQLRRGM MIIIQSLLDD GLLYTTTNSL VGGLLLQKKK SVVKKAAVGE DGGNNSFFQF PQIKKLRRGM MIIIQSLLDD GLLYTTTNSL VGGLLLQKKK SVVKKAAVGE DGGNNTFFQF PQIKKLRRGM MIIIQSLLDD GLLYTTTNSL AGGLLLQKKK SVVVVYYVTE DDDKKEEEQY PQVKKLRRGM MIIIQSLLDD GIIYTTTNSL IGGSSVHTTT SVVKKVVLEG EKK-----PI LYVKKIEEGM MLLLQSLLDD GLLYTTTTSL IGGSSIHSSS TVVKKVVLEE DHHDD---EI LYVKKIEEGM MLLLQSLLDD GLLYSSSTSL ---------- ---------- ---------- --------GK KIIIQSVVDD GLLYTTTNSF LGGAAIQRRR ARRRRVVLND PEELLKEEAP VFLKKLLLGM MLLLQSLLDD GLLYSSSSSL LGGAAICSSS LNNVVIIVKD KEELLKEERP RYVKKLEEGM MLLLQSLLDD GLLYSSSSSL ---------- ---------- ---------- ---------- ---------- ---------- IRRQQVN--- ---------- ---------- ---------M MVVVSSWWDD GVVYSSSSSL IAAQQVN--- ---------- ---------- ---------M MVVVSSWWDD GLLYTTTSSL SSTTWDDDQQ QPPPGGWWKK KLLAN-PLEK EEFFDDDG-- --RSSVRRGG GGGASSP--- SSSSWNNNQQ QPPPGGWWKK KVVVN-PLEK EEFFDDDG-- --RAAVRRGG GGGASSP--- SSTTWDDDQQ QPPPGGAALL LAAAG-PLTD DDYYEEEPG- --RAAIRRGG GGGCSSPSVK SSTTWDDDQQ QPPPGGVVMM MAAVG-GLEK DDYYSSSPG- --RAAIRRGG GGGCSSPSV- SSTTWDDDQQ QPPPDDAAMM MAAVG-ELTK DDFFDDDPG- --RSSIRRGG GGGCSSPSV- GGAAVDDDQQ QPPPGGWWKK KLLAG-PIEP KKFFEEEPG- --RPPVRRGG GGGCSSP--- RRAAWDDDQQ QPPPGGWWKK KVVVN-PMQP NNFFDDDG-- --RVVIRRGG GGGASSP--- AASSWDDDQQ QPPPGGWWKK KAAAD-PLSP GGFFEEEGG- --RPPIRRGG GGGSSSPS-- SSDDWDDDQQ Q---DDEEVV VMMQVTVLKP NNFFDDDGEL GPLAALRRGG GGGCSI---- SSAAWDDDQQ Q---NNEEVV VMMQITALKP NNFFDDDGEL GPLAALRRGG GGGCSI---- SSAAWDDDQQ Q---DDEEVV VMMQITVLKP NNFFDDDGEL GPLAALRRGG GGGCSI---- SSAAWDDDQQ Q---DDEEVV VMMQITVLTP NNFFDDDGEL GPLAALRRGG GGGCSI---- SSAAWDDDQQ Q---DDEEVV VMMQVTVLKP NNFFDDDGEL GPLAALRRGG GGGCSI---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSAAWDDDQQ Q---DDEEVV VMMQVTVLKP NNFFDDDGEL GPLAALRRGG GGGCSI---- SSDDWDDDQQ Q---DDEEVV VMMQITVLKP NNFFDDDGEL GPLAAIRRGG GGGCTI---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSKKWDDDQQ Q---DDEEVV VMMQITELKP NNFFDDDGEG GPLAALRRGG GGGCSI---- SSIIWDDDQQ Q---DDEEVV VMMQITKLKP NNFFDDDGED GPLAAIRRGG GGGCTI---- SSAAWDDDQQ Q---GGKKHH HIIQITELKP NNFFDDDGED GPLAAMRRGG GGGCTI---- SSAAWDDDQQ Q---KKQQHH HIIQITELKP NNFFDDDGED GPLAAMRRGG GGGCTI---- SSAAWDDDQQ Q---EEKKHH HIIQITELSP NNFFDDDGEE GPLAAMRRGG GGGCTI---- SSAAWVVVSS S---EEKKHH HIIQITELTP DDFFDDDGED GPLAAMRRGG GGGCTI---- SSRRWDDDQQ QGGGDDKKHH HMMQITELSP NNFFDDDGEE GPLAAMRRGG GGGCTI---- KKKKWDDDQQ Q---EESSTT TMMQVPEMER DDFFDDDGIG GPLAAMRRGG GGGCTI---- KKKKWDDDQQ Q---EESSTT TMMQIPIMVK NNFFDDDGVG GPLAAMRRGG GGGCTI---- SSTTWDDDQQ Q---NNEEVV VMMQITELTK NNFFDDDGEN GPLAAIRRCG GGGSTI---- SSPPWDDDQQ Q---EEAATT TIIQLVEMKE NNFFDDDGEY GPLPPMRR-- ---------- SSPPWDDDQQ Q---KKQQHH HIILITVISE DDFFDDDAEY GPLPPMRRGG GGGCTINDA- ---------- ---------- ---------- ---------- ---------- ---------- AANNWDDD-- ------KKDD DDDQYYNKEE DDFFDDDYLL G-RAAMRRSS SSSLY----- AANNWDDD-- ------KKDD DDDQFYYKEE QQFFDDDYEL G-RPPMRRAR RRRLYPGNRL ------- ------- KKRR--- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLVVVVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNNSAKKKK PEATCCCRRA AGTAARLLDD DGGGAMQPRT TTASSLLLLL PGPIAYQQEA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -----MAAGR gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FSSAQVLAAS SPEKKKRKTR SVVPGLSSSA KQVPPSAAVV QWAAHHPPGG KKAALIAPPA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------AERR AAAFLQSVVA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMGKEE EEHTQPWFFL ---------- ---------- ---------- ---------- -LLLKKQGCC LLDQNTELLH ---------- ---------- ---------- ---------- ---------- ---------- TLLPNNRTTP TPNLLLPASP PHHPRVRLLV YRTNNVPRLL PCPPPPRHSS LLQHMEGAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MATVVL ---------- ---------- ---------- ---------- ---------- ----MGTVVL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------KRRR EE-------- ---------- ---------- ---------- ---------- ------KRFF IIGPMHFAAL ---------- ----MAVFKK RRDPTFFYYY YYPSMKAEEE DDLYYYAAAC LYTGTTGGRA ---------- ------ALKK PPDPTFFYYY YYPTDRAEEE DDIYYYAAAA LYVGTTGGAP ---------- ------MMRR PPDPTFFHHH HHASLQAEEE EEFYYYLLLL LSPDFFSSRP ---------- ------MMRR PPDPTFFHHH HHASLEAEEE NNFYYYLLLL LSPDFFSSKP ---------- ------MLRR PPDPTFFYYY YYPSLEGEEE KKLFFFLLLM LSPDAASSKP ---------- ------AWKK PPDPSFFYYY YYPSLKAEEE TTIYYYAAAM FDPERRKKQP ---------- ------VWRR PPDPTFFYYY YYPSMKAEEE KKLYYYVVVR LNPMAANNKP ---------- ------AWRR PPDPTFFYYY YYPSMQAEEE RRLYYYAAAL LDPGRREERP ---------- MMAATKT--- CCGPGYYPPP PPTPA-GEEE EEIYYYPPPC IYRNTTGGAP ---------- ---------- ---------- ------GEEE EEIYYYPPPC IYRNTTGGAP RRRGLPG--A HHSSTQG--- CCGPGYYPPP PPSPA-GEEE EEIYYYPPPC IYGNTTGGAP ---------- ---------- ---------- ------GEEE EEIYYYPPPC IYRNTTGGAP ---------- MMAATKG--- CCGPGYYSSS SSTPA-GEEE EEIYYYPPPC IYRNTTGGAP QQQPMPIAAS TTAATKG--- CCGPGYYSSS SSTPA-GEEE EEIYYYPPPC IYRNTTGGAP ---------- MMAATKG--- CCGPGYYSSS SSTPA-G--- ---------- --------AP ---------- MMAATKG--- CCGPGYYSSS SSTPA-GEEE EEIYYYPPPC IYRNTTGGAP SSSGQWQEED TTAATKG--- CCGPGYYPPP PPTPA-GEEE EEIYYYPPPC IYRNTTGGAP TTTYCLVFFT SSPPTKG--- CCGPGYYSSS SSTPA-GEEE EEIYYYPPPC IYRNTTGGAP ---------- MMAATKG--- CCGPGYYSSS SSTPA-GEEE EEIYYYPPPC IYRNTTGGAP AAAVEAAAAA NNGGKTCTAA KKGPGYYAAA AATPAKGEEE KKLYYYTTTC VYNGTTGGKL ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMAKG--- CCGPGYYKKK KKSPA-GEEE EEIYYYPPPC IYRSTTGGKP DDDHGVNEEK KKSS-VGCKK SSGPGYYAAA AASPS-GEEE SSLYYYTTTA VYAGTTGGKP QQQHAVSEEK VVNNNQGCKK SSGPGYYAAA AASPA-GEEE TTLYYYTTTA VYAGTTGGKP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MQVV GGGPGYYAAA AATPA-GEEE KKLYYYTTTA VYTGTTGGKP -----AAAAA NNGGAACGAA TTGPGYYAAA AATPAKGEEE KKLYYYTTTC VYNGTTGGKP -----MSPPN CCGGLKH--- --GPGYYAAA AASPA-GEEE EEVFFFTTTA P---NNAAGP -----MP--- CCPPLKH--- --GPGYYAAA AASPA-GEEE EEVFFFTTTA P---HHAAGP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MSSCKK CCGPGYYAAA AATPANGEEE KKLYYYVVVC VQPNLLDDHG ---------- ---------- ---------- -----SGEEE KKLYYYVVVT VQPNLLDDHG ---------- ---------- --MPGLLIII IIT-ISLRRR FFLFFFNNNW LHGDIIRRDI ---ALAG--A LLAAMGPRAA FFADETTCCC CCQSMITEEE EEFYYYWWWT LGVEGGMMEQ RRRALSGLLA LLAALAPGVV RRADETTCCC CCASMITEEE DDYYYYWWWT LGAEGGVVEQ DDIIIIAAVV NKSSSSTTYS SIHHHKVVVL PYYNNLLHHH FWWNCCSSLL C-PNNGKPRF DDLLLLAAVV DKSSSSTTYG GVYYYKLLLL PYYGGLLHHH FWWNCCSSYY C-PNNAKPRY DDLLLLAAIV KGSSSSTTYG GIHHHTVVVM PNNGGFFHHH FWWNCCSSLL S-PLLTHARF DDLLLLAAIV KGSSSSTTYG GIHHHTVVVM PNNGGFFHHH FWWNCCSSLL S-PLLAHARY DDLLLLAAVV DTSSSSKKFG GIHHHQLLLM PNNGGFFHHH FWWNCCSSLL S-PLLTHARY DDIIIIAAVV DASSSSRRYA AIGGGQVVVM PHHGGLLHHH FWWNCCSSLL C-PNNAHPRY DDMMMMCCVV DQSSSSTTFG GVGGGVTTTM PYYGGLLHHH FWWNCCSSLL C-PNNAHPRY DDLLLLGGLL DDSSSSTTYA AIGGGRVVVM PNNAALLHHH FWWNCCSALL C-PYYAHPRY DDLLLLAAVV DKSSSSQQYS SVHHHRLLLM PYYKKLLHHH SWWNCCSS-- -----FDSNK DDLLLLAAVV DKSSSSHHYS SVHHHRLLLM PHHKKLLHHH SWWNCCSS-- -----FDSDK DDLLLLAAVI DKSSSSQQYC CVHHHRLLLM PNNRRLLHHH SWWNCCSS-- -----FDSTK DDLLLLAAVV DKSSSSQQYC CVHHHRLLLM PHHKKLLHHH SWWNCCSS-- -----YDITK DDLLLLAAVV DKSSSSQQYC CVHHHRLLLM PNNKKLLHHH SWWNCCSS-- -----FDSTK DDLLLLAAVV DKSSSSQQYC CVEEE----- ---------- ---------- ---------- DDLLLLAAVV DKSSSSQQYC CVHHHRLLLM PNNKKLLHHH SWWNCCSS-- -----FDSTK DDLLLLAAVV DKSSSSQQYC CVHHHRLLLM PNNKKLLHHH SWWNCCSS-- -----FDSTK DDLLLLAAVV DKSSSSQQYS SVHHHRLLLM PYYKKLLHHH SWWNCCSS-- -----FDSNK DDLLLLAAVV DKSSSSQQYC CVHHHRLLLM PNNKKLLHHH SWWNCCSS-- -----FDSTK DDLLLLAAVV DKSSSSQQYC CVHHHRLLLM PNNKKLLHHH SWWNCCSS-- -----FDSTK DDLLLLAAVL DSSSSSTTYS SVHHHRLLLV IHHGGLLHHH SWWNCCSS-- -----HDPRF ---------- ---------- ---------M PNNNNLLHHH SWWNCCSS-- -----YDANK DDLLLLAAVV DKSSSSSSYS SVHHHRLLLM PNNNNLLHHH SWWNCCSS-- -----YDSNK DDLLLLAAVV DSSSSSTTYS SVHHHRLLLV PYYGGLLHHH TWWNCCSS-- -----HDPRF DDLLLLAAVL DNSSSSTTYS SVHHHRLLLV PYYGGLLHHH TWWNCCSS-- -----HDPRF ---------- ---------- ---------M PFFGGLLHHH SWWNCCSS-- -----HDARY DDLLLLAAVV DSSSSSSSYS SVHHHRLLLM PFFGGLLHHH SWWNCCSS-- -----HDARY DDLLLLGGVV DNSSSSTTYS SVHHHRLLLV THHGGLLHHH SWWNCCSS-- -----HDPRF DDIIIIFFVV NESSSSTTFC CVSSSRVVVV PHHGGVVHHH TWWNCCSS-- -----HKPSH DDIIIIFFVV NESSSSTTFC CISSSRVVVV PNNGGVVHHH TWWNCCSS-- -----HKPSH ---------- ---------- ---------- ---------- ---------- ---------- DDLLLLAAVV DASSSSTTYC CVHHHRTTTT NSSHHLLHHH SWWNCCSSHH FVP--GKEDR DDLLLLSSVV DESSSSTTYC CIHHHRTTTT NRRGGLLHHH SWWNCCSSYY YVDEESKTDR TTRRRRKKPM VQVVVVLLGG GVKKKDGGGV KVVEEEELLD SPPTRRIL-- ------KRPQ DDLLLLVVIL RGSSSSTTRG GVNNNSVVVV GGGRRAAHHH GFFS------ --------RF DDLLLLVVVA NKSSSSQQYG GVNNNTLLLV GGGRRAAHHH SFFT------ --------RY LIIIPGLRSS SSIIIYYIII NNNPPRRPKK IIKVVEEEVV KKKSRRRLHT TVVVGPDDAI LIIIPALRSS SSIIIYYIVV DDDKKRRPAA VAKIIVVVAA VVGTKKKYHT TVVVGPDDAI LIIIPGLRSS SSIIIYYVII HHHPPTTARR IHKIIEEEII LLATRRRPHT TVVVGPEEGI LIIIPGLRSS SSIIIYYIII DDDPPTTAKK IHKIIEEEVV FFKTRRRPHT TIIIGPDDGI LIIIPGIRSS SSIIIYYIVV EEEPPLLAKK IHKIIEEEVV FFATRRRPHT TIIIGPEEGI LVVVPGLRSS SSIIIYYILL DDDPPLLPFF LAKVVTTTLL AAETRRRPHT TVVVGPGGGI LVVVPDIRSS SSIIITTILL DDDPPTTPKK VVKVVEEELL AAETRRRPHT TVVVGPDDGI LIIIPGIRSS SSIIIHHIVV DDDPPRRPRR IVKVVEEELL HHRTRRRPHT TIIIGPDDGV LIIIPGLMSS SSIIIYYVVV EEEPPRRPKK LHKVVEEEII QQACNNNTHT TSSSLASSGE LIIIPSIISS SSIIIYYVVV EEEPPRRPKK LHKVVEEEII HHACNNNLHT TSSSLASSGE LMMMPCLMSS SSIIIYYVVV DDDPPRRPKK LHKVVDDDII HHACYYYVHT TSSSLASSGE LVVVPALISS SSIIIYYVVV EEEPPRRPKK LHKVVDDDII HHTCFFFFHT TSSSLPSSGE LVVVPSLISS SSIIIYYVVV EEEPPRRPKK LHKVVDDDII HHACFFFLHT TSSSLASSGE ---------- ---------- ---------- -----DDDII HHACFFFLHT TSSSLASSGE LVVVPSLISS SSIIIYYVVV EEEPPRRPKK LHKVVDDDII HHACFFFLHT TSSSLASSGE LVVVPSLISS SSIIIYYVVV EEEPPRRPKK LHKVVDDDII HHACFFFLHT TSSSLASSGE LVVVPSFISS SSIIIYYVVV EEEPPRRPKK LHKVVDDDII HHECTTTPHT TSSSLPTTGE LVVVPSL--- ---------- ---------- ---------- ---------- ---------- LVVVPSLISS SSIIIYYVVV EEEPPRRPKK LHKVVDDDII HHACFFFLHT TSSSLASSGE LIIIPSLLSS SGVVVYYVVV DDDPPRRPSS LHKVVDDDII AAEIFFFPHT TSSSLASSGD LIIIPCLISS SSIIIYYVVV DDDPPRRPRR IHKTTEEEVV FFWCNNNLHT TSSSLGCCGE LIIIPCLISS SSIIIYYVVV DDDPPRRPRR IHKTTEEEVV FFWCNNNPHT TSSSLGCCGE LIIIPSLVSS SGIIIYYVII NNNPPRRPSS LHKVVDDDII IIQTYYYPHT TSSSLASSGE LIIIPGIVSS SGVVVYYVII NNNPPRRPSS LHKVVDDDII SSTTYYYPHT TSSSLASSGE LVVVPSLISS SGIIIYYAII NNNPPRRPSS LYKYYEEEII AAETYYYPHT TAAALASSGE LVVVPSLISS SGIIIYYAII NNNPPRRPSS LYKYYEEEII AADTFFFPHT TAAART--GE LIIIPSLLSS SGVVVYYVVV DDDPPRRPAA LHKVVDDDII AAETFFFPHT TSSSLASSGE LIIIPCLNSS SDIIIYYIII EEE--RRIYY LEHTTKKKLL HHSNFFFPHT TSSSLADDGN LIIIPCLNSS SDIIIYYVII EEE--RRIYY LQHTTKKKLL HHANFFFPHT TSSSLADDGN MVVVRKLSSS SGEEEGGKVV ---------- ---------- ---------- ---------- LVVVPCLNSS SDIIIFFVII DDDPPRRPKK LAKVVDDDVV LLKAAAAPHT TTTTLPNNGN LVVVPSLNSS SDIIIYYILL DDDPPRRPEE IVKTTDDDVV LLKHAAAPHT TTTTLANNGN MLLLLSLDGG GKLLLYYVTT SSSAAWWKQQ FYP--DDDLL IIKLIIISHT TAAAQPNNTA FWWWGGLDTT TNIIIFFIFF DDDPPSSPKK LHKTTFFFVV KKDGGGGPHT TFFFLPGGSM LWWWGGLDTT TSIIIFFVFF DDDPPAAPVV LSKTTFFFVV EEKGGGGPHT TLLLLPGGRM YISSSAALNN -E-EEEGILL LMYSSEEEPW WEEIRDYY-- ---------- ----AAYDFW YISSSAALGG -DREEEGIFF FLDTTEEEPW WEEVRPYY-- ---------- ----AAYDFW YVSSSTTLGG KDTDDDPIFF FIETTDDDVW WEEIRPDD-- ---------- ----HHYDFW YVSSSTTLGG KDTNNNPVFF FIETTEEEVW WEEIRPTT-- ---------- ----HHYDFW YVSSSTTLGG EDTDDDPIFF FIETTEEEIY YEEMRETT-- ---------- ----HHYDFW YVTTTAALNN -E-KKKGIAA AMQSSEEEPW WEEVRPYY-- ---------- ----AAYDGW YISSSAALSS -E-EEEGIFF FIDNNEEEVW WEEIRDYY-- ---------- ----HHYDFW YVSSSAALSS -E-DDDGVFF FVESSDDDPW WEEVRPQQ-- ---------- ----AAYDFW VMVVVNNTGG -LGNNNGFVV VLETTEEEVW WEEKGAPP-- ---------- ----GGYDFY VMIIISSSGG -PGNNNGFVV VLETTEEEVW WEEKGEPP-- ---------- ----GGYDFY VMIIISSTGG -SGNNNGFVV VLETTEEEVW WEEQGAPP-- ---------- ----GGYDFY VMVVVSSTGG -PGNNNGFVV VLKTTEEEVW WEEQGAPP-- ---------- ----GGYDFY VMIIISSSGG -VGNNNGFVV VLETTEEEVW WEERGAPP-- ---------- ----GGYDFY VMIIISSSGG -VGNNNGFVV VLETTEEEVW WEERGAPP-- ---------- ----GGYDFY VMIIISSSGG -VGNNNGFVV VLETTEEEVW WEERGAPP-- ---------- ----GGYDFY VMIIISSSGG -VGNNNGFVV VLETTEEEVW WEERGAPP-- ---------- ----GGYDFY VMIIISSTGG -PGNNNGFVV VLETTEEEVW WEERGSPP-- ---------- ----GGYDFY ---------- ---------- ---------- ---------- ---------- ---------- VMIIISSSGG -VGNNNDSLL LV-RREEEC- ---------- ---------- ---------- IMIIISSCGG -KGNNNGGFF FLSEENNNVG GSSNLPSS-- ---------- ----EERTHY IMIIISSSGG -PGNNNGFVV VLETTEEEVW WEEAGAPP-- ---------- ----GGYDFY IMIIISSSGG -PGNNNGFVV VLETTEEEVW WEEVGSQQ-- ---------- ----GGYDFY LMIIISSCGG -KGNNNGGFF FLSDDNNNVW WEEKGSLL-- ---------- ----GGYDFY IMIIISSCGG -KGNNNGGFF FLSEENNNVW WEEKGSLL-- ---------- ----GGYDFY ILVVVSSCGG -EGNNNGGFF FLSDDNNNIW WEEKGSLL-- ---------- ----GGYDFY ILVVVSSCGG -EGNNNGGLL LLSDDNNNIW WEEKDSLL-- ---------- ----GGYHFY IMIIISSCGG -KGNNNGGFF FLSEENNNVW WEEKGSLL-- ---------- ----GGYDYY IMIIISSTGG -AGTTTGFLL LLKTTEEEPW WPPAETPP-- ---------- ----NNYDFY IMIIISSTGG -AGSSSGFLL LLKTTEEEPW WPPAGVPP-- ---------- ----NNYDFY ---------- ---------- ---------- ---------- ---------- ---------- IMIIISSIGG -AGNNNGDFF FVKNNEEELW WSSRDKLL-- ---------- ----GGYDYY IMIIISSVGG -AGYYYGDFF FISDDNNNCW WTTKDKLL-- ---------- ----GGYDFY LKQQQDDGNN -SSVVVLGII IQHEEGGGLG GEEAQEII-- ---------- ----QQLSNN MITTTGGLNN -DHGGGTLVV VEDGGYYYVW WMMPADQQGG AVVAGDDAAA ADDGGGYDIA LITTTGGLNN -KHGGGTLVV VEAGGYYYVW WIIPDDRRGG AIIKG--KAA ADDGDDYDVA NNELVVSSWW AVPPNNNNN- -IEEEDG--L ELLLLKRRYY RIHWWDLKRR RILLLTTENA NSGMIITSWW TVPPRRRRR- -FEEEEG--L ELLLLKAAYY KLHWWDLKRR RLIIIDDQHV NRDMVVSSWW ALPPPPPPP- -FEEENG--P ELLLLLKKYY RLHWWDLARR RVIIIDDAHA NRDMVVTSWW ALPPPPPPP- -FEEENG--P ELLLLLKKYY RLHWWDLARR RVIIIDDAHA NRDMVVSSWW GLPPPPPPP- -FEEENG--P ELLLLLKKYY KIHWWKLDRR RVIIIDDAHA HYDLVVTSWW GTPPDDDDD- -VEEEDG--P DLLLLLRRYY RLHWWDLRRR RLIIIDDDHV HYDLLLTSWW GTPPRRRRR- -VEEESG--G DLLLLLKKYY RLHWWDLRRR RLLLLDDAYA HYDMVVTSWW GTPPNNNNN- -IEEEGG--P QLLLLLGGYY RLHWWDLRRR RLLLLDDEHV QHNMVVSTWW AAPPNNNNN- -FKKKDGFFA HEEEEALLYY RIFWWDWRHH HILLLQQ-DI QHNMVVSTWW AAPPNNNNN- -FKKKDGFFA HEEEEALLYY HIHWWDWRHH HILLLQQ-DI QHNMIISTWW AAPPNNNNN- -FRRRDGFFA DEEEEALLYY HLHWWDWRHH HILLLTT-DI QHNMIISTWW AAPPNNNNN- -LRRRDGFFA DKKKKALLYY HLYWWDWRRR RVLLLPP-DI QHNMIISTWW AAPPNNNNN- -LRRRDGFFA DEEEEALLYY HLYWWDWHHH HVLLLSS-DI QHNMIISTWW AAPPNNNNN- -LRRRDGFFA DEEEEALLYY HLYWWDWRHH HVLLLSS-DI QHNMIISTWW AAPPNNNNN- -LRRRDGFFA DEEEEALLYY HLYWWDWRHH HVLLLSS-DI QHNMIISTWW AAPPNNNNN- -LRRRDGFFA DEEEEALLYY HLYWWDWRHH HVLLLSS-DI QHNMIISTWW AAPPNNNNN- -VQQQNGFFA DEEEEALLYY HLHWWDWRHH HVLLLLL-DI ---------- ---------- ---------- ---------- ---------- ---------- -------ASS AHSSNNNNN- -RLLLTGSSY PSSSSARRVV IT-------- ---------- EWGFWWSWQQ CCSSLLLLL- -YTTTTGAAM CTTTTAGGVV ISCDDNYMRR RDLLLPP-DG QHNMIISTWW GAPPKKKKK- -FAAALGFFE EQQQQAMMYY SLNWWDWEHH HIIIIDDEDI QHNMIISTWW GAPPKKKKK- -FAAALGFFE DQQQQAHHYY SLNWWDWEHH HVIIIDDKDI QHNMIISTWW GAPPTTTTT- -FTTTKGFFQ HAAAADLLYY HLTIIQLRGG GRLLLDDNTL QHNMIISTWW GAPPKKKKK- -FLLLQGFFQ HAAAADLLYY HLHYYSWGGG GKLLLDDDKL QHKMIISTWW GAPPKKKKK- -FSSSKGFFQ HAAAADLLYY HLHYYSWGGG GKIIIDDETL QHKMIISTWW GAPPKKKKK- -FSSSKGFFQ HAAAADLLYY HLHYYSWGGG GKIIIDDPTL QHKMIISSWW GAPPAAAAA- -FRRRTGFFQ HQQQQDLLYY HLHYYDWGGG GKLLLDDSTL QRNMIISTWW GSPPNNNNN- -IKKKKGFFA HGGGGELLYY SVHFFEWSKK KLIIIDDQLL QRNMIISTWW GSPPNNNNN- -IKKKKGFFA HPPPPELLYY SVHFFEWTKK KLIIIDDMRL ------SIRR GGPPVVVVV- -VCCCRDEEK CPPPPELLVV CKRYY----- ---------- QFNMVVASWW GAPPKKKKK- -FRRRRGYYT DDDDDDQQYY RLNYYRWERR RFIIIDDDDT QFDMVVSSWW GAPPNNNNN- -WRRRRGWWV DEEEEDQQYY RLNYYKWTQQ QYIIIDDSDT NRESEESDPP DEPPIIIII- -AFFFESSSF LKKKKTLLKK HVAVVL---- ---------- LKNMLLTSFF TGWWSSSSSY YMDDDFGQQQ DEEEEARRFF TIVWWDLTRR RKFFFNNGP- LKNLVVTSFF TGWWNNNNNY YMDDDFGKKA DEEEEAHHFF TVVWWDLTKK KKFFFDDGP- LL-----LLL GNVVVVSLSI IIIWWWWEDG NNAAAEEVII AAPPLEGGNP PEEILPFAAV LL-----VLL GNVVLLNTSI IIIWWWWEDG QQAAAEEVII AAPPFEGGPP PPPVLDFMMV LL-----VEE GGVVVVDTSI IIIWWWWEGG HHVVVKKTAI AAPPATAAEP PPPLLGFAAV LL-----VEE GGVVVVDTSI IIIWWWWEGG HHAAAEETAI PPPPAPKKKP PPPLLGFAAV LL-----IDD GGVVVVDTAI IIIFFFWDDG EEAAAKKTII PPPPADAADP PDDLLGFAAC FF-----LAA GNVVIISLSI IIIWWWWDKD AAVVVRRVII AAAAADPPQP PPPVLGFAAV LL-----LAA GNVVVVSLSI IIIWWWWDNG HHLLLKKVII AAPPASEEQP PPPILPFAAV LL-----LTT GGVVVVSLSV VVVWWWWQNG GGIIIRRVII AAPPAEPPQP PPPLLDFAAV PP---LLITT GGAALLSSYK KKKNNNE--- --------TS EEVVIQVVSK KVVKGMLEEM PP---LLITT GGAALLSSYK KKKNNNG--- --------TS EEVVIQVVSK KVVKGMLEEM PP---LLIAA GGAALLSSYK KKKNNNG--- --------TS EEVVIQVVPK KVVKGMLEEM PP---LLIAA GGAALLSSFK KKKNNND--- --------TS QQVVIQVVPK KVVKGMLEEM PP---LLIAA GGAALLSSYK KKKNNNG--- --------TS EEVVIQVVPK KVVKGLLEEM PP---LLIAA GGAALLSSYK KKKNNNG--- --------TS EEVVIQVVPK KVVKGLLEEM PP---LLIAA GGAALLSSYK KKKNNNG--- --------TS EEVVIQVVPK KVVKGLLEEM PP---LLIAA GGAALLSSYK KKKNNNG--- --------TS EEVVIQVVPK KVVKGLLEEM PP---LLISS GGAALLSSYK KKKNNNG--- --------TS EEVVIEVVPK KVVKGMLEEM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AANNPLLLNN DVEEVVSFSD DDDPPPA--- --------AV KKKKLDLLYV VVVAKGVSSL PP---LLIAA GGAALLSSYK KKKEEED--- --------KA EEVVIKVVSK KVVEGALEEM PP---LLIDD GGAALLSSYK KKKEEED--- --------KA EEVVIQVVSK KVVEGPMEEM PP---LLIDD GGAALLSSFK KKKTTTD--- --------SS EEAAIPVVPK KVVQNILEEM PP---LLIDD GGAALLTSFK KKKTTTD--- --------SN EEVVISVVPK KVVQNFLEEM PP---LLIDD GGAALLSSFK KKKNNND--- --------TS EEVVISVVPK KVVENILEEM PP---LLIDD GGAALLSSFK KKKNNND--- --------TS EEVVISVVPK KVVENILEEM PP---LLVDD GGAALLTSFK KKKTTTD--- --------SS EEAAISIIPK KVVRNILEEM PP---LLVEE AGAALLGSHP PPPVVVE--- --------TA TTVVAFIISK KVVSGALEEM PP---LLVEE AGAALLGSHP PPPDDDK--- --------VT SSVVATIISK KVVENALDDM ---------- ---------- ---------- ---------- ---------- ---------- PP---LLINN GGAAFFXXX- ---------- ---------- ---------Q QGGENEIMMM PP---LLIAA GGAALLNAKK KKKKKKD--- -------FEK VVDDIPGGLD DTTGSVADDM ---------- ---------- ---------- ---------- ---------- ---------- -----LLINN ATAALLTSYE EEEDDDA--- ---------- -----EWWAA AVVADGNAAD -----LLINN CSAALLTSYE EEEDDDE--- ---------- -----EWWAA AVVADGEAAK PTTDIIDDDI ISLLDDDFFF FFLLLSLWGI VRQQQQYYDI IISPPVTTKV KGFHHRADDH PTTDIIDDDI ISLLDDDFFF FFLLVSLWGL LRQQQQYYDI IITPPRAARV KGYHHREPPH PTTDIIDDDL LSLLDDDFFF FFLLVSCWGT MRQQQQYYDV VVSPPVAASV RGARRRAPPH PTTDIIDDDL LSMMDDDFFF FFLLVSCWGT MRQQQQYYDV VVSPPKAASV HGARRRTPPH PTTDIIDDDL LSLLDDDYYY YYLLVACWGL MHQQQQYYDV VVSPPVTTKV EGVKKKTPPH PTTDIIDDDL LSMMDDDFFF FFLLVSCWGT LLQQQQYYDV VVSPPKTTKV RGVSSRATTH PTTDIINNNL LSVVDDDFFF FFLLVSCWGT LHQQQQYYDV VVSPPRTTKV QGVRRRAGGH PTTDIINNNL LSLLDDDFFF FFLLVSCWGT LRQQQQYYDV VVSPPRTTSV RGVRRKAAAH PTTDIILLLL LSLLDDDFFF FFLLFSNWLH IRQQQQYYDI IISPPRTTQI FGIVVRGGGS PTTDIILLLL LSLLDDDFFF FFLLFSNWLH IRQQQQYYDI IISPPRTTQI FGIVVKGGGS PTTDIILLLL LSLLDDDFFF FFLLFSNWLH LRQQQQYYDI IISPPRTTQL FGIVVKGGGP PTTDIILLLL LSLLDDDFFF FFLLFSNWLH IRQQQQYYDV VVSPPRTTQL FGIVVKDGGP PTTDIILLLL LSLLDDDFFF FFLLFSNWLH LRQQQQYYDI IISPPRTTQL FGIVVKGGGP PTTDIILLLL LSLLDDDFFF FFLLFSNWLH LRQQQQYYDI IISPPR---- ---------- PTT------- ---------- ---------- ---------- ---------- ---------- PTTDIILLLL LSLLDDDFFF FFLLFSNWLH LRQQQQYYDI IISPPRTTQL FGIVVKGGGP PTTDIILLLL LSLLDDDFFF FFLLFNNWLH MRQQQQYYDI IISPPRVVQI FGIVVKGGGP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SPPPAAWWWI IFFFSSDLLL LLIIFLS--- ---------- ---------- ---------- PTTDIILLLI ISLLDDDFFF FFLLFSNWLH IRQQQQYYDI IITPPKVVQI FGILLRGGGP PTTDIILLLI ISLLDDDFFF FFLLFSNWLH IRQQQQYYDI IITTTKVVQI FGIQQRGGGP PTTDFFLLLI ISLLDDDFFF FFLLFVNWLH IRQQQQYYNI IIELLVTTQL WGIQQKGSSP PTTDFFLLLI ISLLDDDFFF FFLLFVNWLH IRQQQQYYNI IIEVVKTTQV WGIQQKGSSP PTTDFFLLLI ISLLDDDFFF FFLLFVNWLH IRQQQQYYNI IIEPPVTTQI WGLQQKGSSP PTTDFFLLLI ISLLDDDFFF FFIIFVNWLH IRQQQQYYNI IIEPPVTTQI WGLQQKGSSP PTTDFFVVVI ISLLDDDYYY YYLLLVNWLH IRQQQQYYNI IIEPPVAAQV WGLQQKGSSE PTTDIILLLI ISMMDDDFFF FFLLVSCWLH IRQQQQYYDI IISPPKNNQV YGVHHTESSN PTTDIILLLI ISMMDDDFFF FFLLVSCWLH IRQQQQYYDI IISPPKNNQV FGIHHSETTT ---------- ---------- ---------- ---------- ---------- ---------- GTTDIILLLI ISLLDDDYYY YYLLFSNWRH VRQQQQYYDI IISRRRTTQV FGIQQRDAAP GSSDIIIIII ISLLDDDFFF FFLLVNCWRH VRQQQQYYDI IITPPKTTQL FGICCSDLLP ---------- ---------- ---------- ---------- ---------- ---------- IVVDIISSSI IAAADDDTTT TTLLINSFMD TRLLLLFFDI IISPPFIIEK VRVNN----- VVVDIISSSI ISNNDDDRRR RRLLVNTFMD TRLLLLFFDI IISPPRVVEK TAVNN----- HHP------- ---------- -----AHKKL TTMLESRDDD RRRRRVYYYN SYSDNQQFFE HHP------- ---------- -----SAEEA TTMISSRDDD RRRRRVYYYN SYSNNQQFF- HHP------- ---------- -----NRTTF AAMVESRDDD RRRRRVYYYN SYSDDQQFFD HHP------- ---------- -----NKAAF AAMVESRDDD RRRRRVYYYN SYSDDQQFFD HHP------- ---------- -----NKTTF GGMVESRDDD KKKRRVYYYN SYSDEQQFFG HHP------- ---------- --AAAKGAAL NNMVESRDDD RRRRRVYYYN SYGDPQQFFE HHP------- ---------- --AAATAEEL NNMVESRDDD RRRRRVYYYN SYRDEQQFFD HHP------- ---------- -----AGPPL NNMVESRDDD RRRRRVYYYN SYADEQQFFV SSVVLEELTQ QQPPPEEPPP LVVVVKKRRI PPMIQSLDDD KKKRRLYYYT SYSDKQQFFP SSVVLEELTQ QQPPPEEPPP LVVVVKKRRV PPMIQSLDDD KKKRRLYYYT SYSDKQQFFP PPVVLEELKQ QQPPPEEPPP LVVVVKKKKV PPMIQSLDDD KKKRRLYYYT SYSDKQQFFP PPVVLDDLDQ QQPPPEEPPP LVVVVKKQQV AAMIQSLDDD KKKRRLYYYT SYSDKQQFFP PPVVLEELKQ QQPPPEEPPP LVVVVKKRRV AAMIQSLDDD KKKRRLYYYT SYSDKQQFFP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPVVLEELKQ QQPPPEEPPP LVVVVKKRRV AAMIQSLDDD KKKRRLYYYT SYSDKQQFFP PPVVLEELKQ QQPPPEEPPP LVVVVKKRRV PPMIQSLDDD KKKRRIYYYT SYSDKQQFFP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPVVLEELEQ QQPPPDDPPP VIVVVKKKKV PPMIQSLDDD KKKRRLYYYN SYSDKQQFFP PPVVLEELEQ QQPPPDDPPP VTVVVKKIII PPMIQSLDDD KKKRRIYYYS SYSDKQQFFP PPVAIGGKTQ QQSSSDDVVV PEIIIQQKKL RRMIQTLDDD KKKRRLYYYN SFSDKQQFFP PPVAVKKETQ QQSSSDDVVV PEIIIQKKKL RRMIQSLDDD KKKRRLYYYN SFSDKQQFFP PPVAVGGNSQ QQFFFDDVVV PQIIIKKSSL RRMIQSLDDD KKKRRLYYYN SFSDRQQFFP PPVAVGGNTQ QQFFFEEVVV PQIIIKKSSL RRMIQSLDDD KKKRRLYYYN SFSVVSSFFP EEVYVTTKEQ QQYYYSSVVV PQVVVKHRRL RRMIQSLDDD KKKRRIYYYN SFSDEQQFFQ NNVVLEE--P PPIIIEEAAA LYVVVKRKKI EEMLQSLDDD KKKRRLYYYT SYKDDQQFFP TTVVLEED-E EEIIIPPAAA LYVVVKRQQI EEMLQSLDDD KKKRRLYYYT SYKDDQQFFP ---------- ---------- ---------- --KIQSVDDD KKKRRLYYYN SYSDKQQFFP PPRVLNNLKA AAPPPEEPPP VFLLLKRRRL LLMLQSLDDD RRRRRLYYYS SFSDKQQFFP PPNIVKKLKR RRPPPPPAAA RYVVVKRRRL EEMLQSLDDD KKKRRLYYYS SYSDKQQFFP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MVSSWDDD KKKRRVYYYS SLAD------ ---------- ---------- ---------- --MVSSWDDD QQQRRLYYYS SLAD------ GKGMVVVN-- ----SGGGLE IDDDFFVVDG GEE------V RRRRLLLSGG DDAASYPPPP GRGMAAAN-- ----EGGGLE LEEEFFVVDG GRR------V RRRRLLLWGG DDAATFPPPP GPAQVVVH-- ----DGGGLT LAAAYYVVEP PDD------I RRRRLLLEGG DDCCTFPPPP GPGEVVVN-- ----NGGGLE LDDDYYVVSP PDD------I RRRRLLLEGG DDCCTFPPPP DGAMVVVN-- ----NGGGLT LDDDFFVVDP PAA------I RRRRLLLEGG DDCCTFPPPP GDGMVVVD-- ----NGGGIE FDDDFFLLEP PKK------V RRRRLLLQGG DDCCSYPPPP GKGMVVVD-- ----DGGGMQ FDDDFFVVDG GEE------I RRRRLLLQGG DDAASYPPPP GRGIAAAE-- ----GGGGLS LDDDFFTTEG GDD------I RRRRLLLEGG DDSSSYPPPP DIRGSSSLDD DTTTNGGGLK LNNNFFVVDG GKKPLPPPPL RRRRYYYPGG DDCCSW---- NIRGSSSLDD DTTTNGGGLK LNNNFFVVDG GKKPLPPPPL RRRRYYYPGG DDCCSW---- DIRGSSSLDD DTTTKGGGLK LNNNFFVVDG GKKPLPPPPL RRRRYYYPGG DDCCSW---- DIRGSSSLDD DTTTKGGGLT LNNNFFVVDG GKKPLPPPPL RRRRYYYPGG DDCCSW---- DIRGSSSLDD DTTTKGGGLK LNNNFFVVDG GKKPLPPPPL RRRRYYYPGG DDCCSW---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DIRGSSSLDD DTTTKGGGLK LNNNFFVVDG GKKPLPPPPL RRRRYYYPGG DDCCSW---- DIRGSSSLDD DTTTKGGGLK LNNNFFVVDG GKKPLPPPPI RRRRYYYPGG DDCCSW---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DIKGSSSLDD DTTTKGGGLK LNNNFFVVDG GKKPGPPPPL RRRRYYYPGG DDCCSW---- DLKGAAALDD DTTTKGGGLK LNNNFFVVDG GKKPDPPPPI RRRRYYYPGG DDCCSW---- GVEGSSSLDD DTTTKGGGLK INNNFFVVDG GAAPDPPPPM RRRRYYYPGG DDCCSW---- KVEGSSSLDD DTTTNGGGLK INNNFFVVDG GAAPDPPPPM RRRRYYYPGG DDCCSW---- EMDGSSSIDD DTTTKGGGLS INNNFFVVDG GDDPEPPPPM RRRRYYYPGG DDCCSW---- EMEGSSSIDD DTTTKGGGLT INNNFFVVDG GDDPDPPPPM RRRRYYYPGG DDCCSW---- DVKGSSSLDD DTTTKGGGLS INNNFFVVDG GAAPEPPPPM RRRRYYYPGG DDCCSW---- EVKGAAAVND DPPPSGGKME INNNFFIIDG GKKEGPPPPM RRRRYYYPGG DDCCSW---- EVRGAAALDD DPPPTGGHMV INNNFFIIDG GKKPGPPPPM RRRRYYYPGG DDCCSW---- NVKGSSSLDD DTTTKGGGLT VNNNFFVVDG GKKPNPPPPI RRRRFFFPCG DDSSSL---- EVAGGGGVDD DVVVNGGGMK LNNNFFVVDG GGGPYPPPPM RRRR------ ---------- KVSGGGGVDD DTTTNGGGIS LNNNFFVVDA ANNPYPPPPM RRRRYYYPGG DDCCSWNNNN ---------- ---------- ---------- ---------- ---------- ---------- --KGKKKALA AYYYWDDGKE LVVVFFVVDY YEEGL----M RRRRFFFGSS AALLS----- --KGKKKELL LYYYWDDGKE LKKKFFIIDY YAAKL----M RRRRFFFGAR AALLAAGGGG ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QQQQVVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSAKKSSE EETTAPPPTG GTTTAAARRL DDAAMQPTTT QLLLSLTTPG GSSPVVVKKA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AYEEAAAATF SSSAIQVLLL SSRKKGRTRR VVPPSAQVPP SSQQAWAWWP PPPAAVVVLI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A AAEAATTTLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------GGG GGKHHAAAQP ---------- ---------- ---------- ---------- -----LLNNQ QQGDDTTTNT ---------- ---------- ---------- ---------- ---------- ---------- -MGGRRSSPT LPPPLNNRRR PTHLLAPSPP HHPPRVRTNN VVPPRCPHHR RRHQQIIIME ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MA ---------- ---------- ---------- ---------- ---------- --------MG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------K KKR------- ---------- ---------- ---------- ---------- ---------K KKRGGSSSMH ---------- --MMAAAVPF FRPPFYPSPP KAAMKKPPPL VAAAAACLYY TGGTGGIIND ---------- -------AKL LPPPFYPTPP RAAMRRPPPI VAAAAAALYY VGGTGGVVND ---------- -------MSM MPPPFHASPP EAAMQQPPPF TLLLLLLLSS PDDFSS---D ---------- -------MTM MPPPFHASPP KAAMEEPPPF TLLLLLLLSS PDDFSS---D ---------- -------MTL LPPPFYPSAA KAAMEEPPPL TLLLLLMLSS PDDASS---D ---------- -------ATW WPPPFYPSPP RAAAKKPPPI VAAAAAMFDD PEERKK---D ---------- -------VTW WPPPFYPSPP RAAVKKPPPL VVVVVVRLNN PMMANNGG-D ---------- -------ASW WPPPFYPSPP KAAMQQPPPL VAAAAALLDD PGGREE---D ---------- -MTTKKKTK- -CPPYPTPLL EMMK--PPPI LPPPPPCIYY RNNTGGTTED ---------- ---------- ---------- ---M--PPPI LPPPPPCIYY RNNTGGIIED AAALLPPPAA AHTTQQQGK- -CPPYPSPLL EMMK--PPPI LPPPPPCIYY GNNTGGIIED ---------- ---------- ---------- -MMK--PPPI LPPPPPCIYY RNNTGGIIED ---------- -MTTKKKGN- -CPPYSTPLL EMMK--PPPI LPPPPPCIYY RNNTGGTTED SSAMRPPPSS STTTKKKGN- -CPPYSTPLL EMMK--PPPI LPPPPPCIYY RNNTGGTTED ---------- -MTTKKKGN- -CPPYSTPLL EMMK------ ---------- ------TTED ---------- -MTTKKKGN- -CPPYSTPLL EMMK--PPPI LPPPPPCIYY RNNTGGTTED WWLQLWWWDD DTTTKKKGD- -CPPYPTPQQ EMMK--PPPI LPPPPPCIYY RNNTGGTTED EEHCTLLLTT TSTTKKKGN- -CPPYSTPLL EMMK--PPPI LPPPPPCIYY RNNTGGTTED ---------- -MTTKKKGN- -CPPYSTPLL EMMK--PPPI LPPPPPCIYY RNNTGGTTED GGAETAAAAA ANKKTTTCHT TKPPYATPLL EMMEKKPPPL VTTTTTCVYY NGGTGGIIND ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AAKKKGS- -CPPYKSPLL DMMK--PPPI LPPPPPCIYY RSSTGGIIND TTLGVVVVKK KK--VVVGCC CSPPYASPII EMMS--PPPL VTTTTTAVYY AGGTGGIIED TTLAVVVVKK KVNNQQQGCC CSPPYASPLL EMMS--PPPL VTTTTTAVYY AGGTGGIIED ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MLQ QGPPYATPLL AMMS--PPPL VTTTTTAVYY TGGTGGIIDD ----MAAAAA ANAAAAACGG GTPPYATPLL EMMEKKPPPL VTTTTTCVYY NGGTGGIIND -----MMMNN NCLLKKKHG- --PPYASPAA DIIK--PPPV VTTTTTAP-- ---NAAAADD -----MMM-- -CLLKKKHG- --PPYASPAA DIIK--PPPV VTTTTTAP-- ---HAARRDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMSSSSKC CCPPYATPLL DVVRNNPPPL VVVVVVCVQQ PNNLDDEEED ---------- ---------- ---------- -MMRSSPPPL TVVVVVTVQQ PNNLDDEEPD ---------- ---------- --PPLIT--- DLLISSDDDL SNNNNNWLHH GDDIRRQQYT ---LAAAAAA ALMMGGGPFR RFDDTCQSPP YPPKIIGGGF VWWWWWTLGG VEEGMMGGDD FFLLVSSSAA ALLLAAAPAG GRDDTCASPP YKKKIIGGGY VWWWWWTLGG AEEGVVGGDD FIADDNKKEE EYYYIVVHKV LYYINLLLHH HHHFFGWNCS SLCC-GGPPI RFLVPGRRSS FLADDDKKPP PYYYVIIYKL LYYIGLLLHH HHHFFGWNCS SYCC-AAPPL RYLVPARRSS ALADDKGGSS SYYYIVVHTV MNNTGFFFHH HHHFFGWNCS SLSS-TTAAL RFLIPGRRSS ALADDKGGPP PYYYIVVHTV MNNKGFFFHH HHHFFGWNCS SLSS-AAAAI RYLIPGRRSS GLADDDTTEE EFFFIVVHQL MNNKGFFFHH HHHFFGWNCS SLSS-TTAAL RYLIPGRRSS AIADDDAAPP PYYYIVVGQV MHHAGLLLHH HHHFFGWNCS SLCC-AAPPM RYLVPGRRSS AMCDDDQQSS SFFFVVVGVT MYYTGLLLHH HHHFFGWNCS SLCC-AAPPV RYLVPDRRSS ALGDDDDDGG GYYYIVVGRV MNNAALLLHH HHHFFGWNCS ALCC-AAPPV RYLVPGRRSS YLADDDKKPP PYYYVIIHRL MYYLKLLLHH HHHSSGWNCS S----FFSSK NKLLPGMMSS YLADDDKKPP PYYYVIIHRL MHHLKLLLHH HHHSSGWNCS S----FFSSK DKLLPSIISS YLADDDKKPP PYYYVIIHRL MNNLRLLLHH HHHSSGWNCS S----FFSSK TKLLPCMMSS YLADDDKKPP PYYYVIIHRL MHHLKLLLHH HHHSSGWNCS S----YYIIK TKLLPAIISS YLADDDKKPP PYYYVIIHRL MNNLKLLLHH HHHSSGWNCS S----FFSSK TKLLPSIISS YLADDDKKPP PYYYVIIE-- ---------- ---------- ---------- ---------- YLADDDKKPP PYYYVIIHRL MNNLKLLLHH HHHSSGWNCS S----FFSSK TKLLPSIISS YLADDDKKPP PYYYVIIHRL MNNLKLLLHH HHHSSGWNCS S----FFSSK TKLLPSIISS YLADDDKKPP PYYYVIIHRL MYYLKLLLHH HHHSSGWNCS S----FFSSK NKLLPSIISS YLADDDKKPP PYYYVIIHRL MNNLKLLLHH HHHSSGWNCS S----FFSSK TKLLPS---- YLADDDKKPP PYYYVIIHRL MNNLKLLLHH HHHSSGWNCS S----FFSSK TKLLPSIISS YLADDDSSPP PYYYVIIHRL VHHIGLLLHH HHHSSGWNCS S----HHPPA RFLLPSLLSS ---------- ---------- MNNTNLLLHH HHHSSGWNCS S----YYAAK NKLLPCIISS YLADDDKKPP PYYYVIIHRL MNNVNLLLHH HHHSSGWNCS S----YYSSK NKLLPCIISS YLADDDSSPP PYYYVIIHRL VYYVGLLLHH HHHTTGWNCS S----HHPPA RFLAPSVVSS YLADDDNNPP PYYYVIIHRL VYYVGLLLHH HHHTTGWNCS S----HHPPA RFLVPGVVSS ---------- ---------- MFFVGLLLHH HHHSSGWNCS S----HHAAA RYLLPSIISS YLADDDSSPP PYYYVIIHRL MFFVGLLLHH HHHSSGWNCS S----HHAAV RYLLPSIISS YLGDDDNNPP PYYYVIIHRL VHHVGLLLHH HHHSSGWNCS S----HHPPA RFLLPSLLSS AIFDDNEEDD DFFFVIISRV VHHIGVVVHH HHHTTGWNCS S----HHPPE SHLVPCNNSS AIFNNNEEEE EFFFIIISRV VNNIGVVVHH HHHTTGWNCS S----HHPPE SHLVPCNNSS ---------- ---------- ---------- ---------- ---------- --MPRKSSSS YLADDDAAPP PYYYVIIHRT TSSKHLLLHH HHHSSGWNCS SHFFVGGEEP DRLLPCNNSS YLSDDDEEPP PYYYIVVHRT TRRKGLLLHH HHHSSGWNCS SYYYVSSTTP DRLLPSNNSS DRKRRVQQFF FGGGVLLKDG VVVLEEEELL LDDSSQPTRI L------RRQ PQMQLSDDGG KLVDDRGGAA ARRRVIINSV VGG-RAAAHH HHHGGGFS-- ---------- RFFTGGDDTT KLVDDNKKPP PYYYVVVNTL VGG-RAAAHH HHHSSDFT-- ---------- RYLAGGDDTT SSSRIYIDTK KNNPPEEIIK VIEKVVVGRR RLLLTHHHHG PAIISSLNE- -EG--EGPGG SSSRIYVDTK KDDKKRRVAK IVEVRRRGKK KYYYTHHHHG PAIISSLGP- -DGRREGPGG SSSRIYIDTK KHHPPQQIHK IIELKKKGRR RPPPTHHHHG PGIVSSLGAG KDGTTDGAPP SSSRIYIDTK KDDPPKKIHK IIEFKKKGRR RPPPTHHHHG PGIVSSLGGG KDGTTNGPPP SSSRIYVDVK KEEPPKKIHK IIEFKKKGRR RPPPTHHHHG PGIVSSLGGG EDGTTDGPPP SSSRIYLDTK KDDPPKKLAK VIEARRRGRR RPPPTHHHHG PGIVTTLNA- -EG--KGPGG SSSHITLDTK KDDPPQQVVK VIDARRRGRR RPPPTHHHHG PGIISSLSP- -EG--EGPGG SSSRIHVDTK KDDPPEEIVK VIEHRRRGRR RPPPTHHHHG PGVVSSLSP- -EG--DGPGG SSSRIYVDVG GEEPPAALHK VIEQKKKNNN NTTTTHHHHL AGEMVVTGD- -LQGGNGKGG SSSRIYVDVG GEEPPAALHK VIEHKKKNNN NLLLTHHHHL AGEMIISGD- -PQGGNGKGG SSSRIYVDVG GDDPPAALHK VIEHKKKGYY YVVVTHHHHL AGEMIITGD- -SKGGNGKGG SSSRIYVDVG GEEPPAALHK VIEHKKKNFF FFFFTHHHHL PGEMVVTGD- -PEGGNGKGG SSSRIYVDVG GEEPPAALHK VIEHKKKEFF FLLLTHHHHL AGEMIISGD- -VKGGNGKGG ---------- ---------- ---HKKKEFF FLLLTHHHHL AGEMIISGD- -VKGGNGKGG SSSRIYVDVG GEEPPAALHK VIEHKKKEFF FLLLTHHHHL AGEMIISGD- -VKGGNGKGG SSSRIYVDVG GEEPPAALHK VIEHKKKEFF FLLLTHHHHL AGEMIISGD- -VKGGNGKGG SSSRIYVDVG GEEPPAALHK VIEHKKKGTT TPPPTHHHHL PGEMIITGD- -PKGGNGKGG ---------- ---------- ---------- ---------- ---------- ---------- SSSRIYVDVG GEEPPAALHK VIEHKKKEFF FLLLTHHHHL AGEMIISGD- -VKGGNGKDD SGGRVYVDTA ADDPPTTLHK VVEANNNGFF FPPPTHHHHL AGDMIICGD- -KEGGNAAGG SSSRIYVDVG GDDPPAAIHK TVEFKKKGNN NLLLTHHHHL GGEMIISGD- -PYGGNGKGG SSSRIYVDVG GDDPPAAIHK TVEFKKKGNN NPPPTHHHHL GGEMIISGD- -PCGGNGKGG SGGRIYIDTK KNNPPSSLHK VVDIKKKGYY YPPPTHHHHL AGEMIICGD- -KDGGNAEGG SGGRVYIDTK KNNPPAALHK VVESKKKGYY YPPPTHHHHL AGEMIICGD- -KDGGNAEGG SGGRIYIDTK KNNPPAALYK YVDAKKKGYY YPPPTHHHHL AGELVVCGD- -EEGGNAKGG SGGRIYIDTK KNNPPAALYK YVDAKKKGFF FPPPTHHHHR TGELVVCGD- -EEGGNAKGG SGGRVYVDTL LDDPPAALHK VVEAKKKGFF FPPPTHHHHL AGEMIICGD- -KEGGNAAGG SDDRIYINVE EEE--KKLEH TIEHLLL-FF FPPPTHHHHL AGNMIITGE- -ANGGTPSGG SDDRIYINVE EEE--EELQH TIEHLLL-FF FPPPTHHHHL AGNMIITGE- -ADGGSPSGG SGGVEGVFVG G--------- ---------- ---------- ---------- ---------- SDDRIFIDTG GDDPPAALAK VIELGGGDAA APPPTHHHHL PGNMIIIGD- -AEGGNAKGG SDDFIYLDVV VDDPPKKIVK TIDLSSSNAA APPPTHHHHL AGNMIIVGD- -AEGGYAKGG GKKRLYTTSL LSSAADDFYP ---IFFFVII ISSSTDDDDQ PTAKQQGNE- -SLSSVPVLL TNNRIFFDVH HDDPPNNLHK TIDKSSSGGG GPPPTFFFFL PSMITTLND- -DDHHGGRTT TSSKIFFDVH HDDPPRRLSK TITESSSGGG GPPPTYYYYL PRMITTLNN- -KDHHGGRTT IIIILLLLHY YFEELGWEEI GDQYY----- -------LLL LAYDDWWWWN NNL--PPNNV IIIIFLLLHD DFEEIGWEEV GPQYY----- -------FFF FAYDDWWWWN NNL--PPSSV IIIIFMMMCE EFDDLGWEEI GPQDD----- -------KKK KHYDDWWWWN NNL--PPRRY VVVVFMMMCE EFEELGWEEI GPQTT----- -------LLL LHYDDWWWWN NNL--PPRRY IIIIFLLLCE EFEELGYEEM GEQTT----- -------KKK KHYDDWWWWN NNL--PPRRY IIIIALLLAQ QFEELGWEEV GPQYY----- -------FFF FAYDDWWWWH HHL--GGYYT IIIIFLLLHD DLEELGWEEI GDQYY----- -------LLL LHYDDWWWWH HHL--GGYYT VVVVFMMMHE EFDDLGWEEV GPQQQ----- -------LLL LAYDDWWWWH HHL--GGYYT FFFFVLLLGE EFEEKGWEEK GASPP----- -------MMM MGYDDWWWWQ QQP--RRHHV FFFFVLLLGE EFEEKGWEEK GEAPP----- -------MMM MGYDDWWWWQ QQP--RRHHI FFFFVLLLGE EFEEKGWEEQ GAAPP----- -------MMM MGYDDWWWWQ QQP--RRHHV FFFFVLLLGK KFEEKGWEEQ GAAPP----- -------LLL LGYDDWWWWQ QQP--RRHHV FFFFVLLLGE EFEEKGWEER GAAPP----- -------SSS SGYDDWWWWQ QQP--RRHHV FFFFVLLLGE EFEEKGWEER GAAPP----- -------LLL LGYDDWWWWQ QQP--RRHHV FFFFVLLLGE EFEEKGWEER GAAPP----- -------LLL LGYDDWWWWQ QQP--RRHHV FFFFVLLLGE EFEEKGWEER GAAPP----- -------LLL LGYDDWWWWQ QQP--RRHHV FFFFVLLLGE EFEEKGWEER GSAPP----- -------MMM MGYDDWWWWQ QQP--RRHHV ---------- ---------- ---------- ---------- ---------- ---------- SSSSLLLLP- -LEESG---- ---------- ---------- ---------- ---------- GGGGFLLLDS SFNNKGGSSN FPISS----- -------KKK KERTTLLLLE EENYYAAWWL FFFFVLLLGE EFEEKGWEEA EAAPP----- -------FFF FGYDDWWWWQ QQP--RRHHV FFFFVLLLGE EFEEKGWEEV ESAQQ----- -------FFF FGYDDWWWWQ QQP--RRHHV GGGGFLLLDS SFNNKGWEEK HSPLL----- -------FFF FGYDDWWWWQ QQP--RRHHT GGGGFLLLDS SFNNKGWEEK HSPLL----- -------FFF FGYDDWWWWQ QQP--RRHHT GGGGFLLLDS SFNNKNWEEK HSPLL----- -------FFF FGYDDWWWWQ QQP--RRHHT GGGGLLLLDS SFNNKNWEEK ISPLL----- -------YYY YGYHHWWWWQ QQP--RRHHT GGGGFLLLDS SFNNKGWEEK HSPLL----- -------FFF FGYDDWWWWQ QQP--RRHHT FFFFLLLLGK KFEEKGWPPA KTVPP----- -------FFF FNYDDWWWWQ QQP--RRRRV FFFFLLLLGK KFEEKGWPPA KVVPP----- -------FFF FNYDDWWWWQ QQP--RRRRI ---------- ---------- ---------- ---------- ---------- ---------- DDDDFEEEDK KFEEVGWSSR RKALL----- -------CCC CGYDDWWWWQ QQP--HHFFV DDDDFLLLDS SFNNIGWTTK KKALL----- -------CCC CGYDDWWWWQ QQP--YYFFV GGGGITTTKH HNGGSAGEEA FEEII----- -------LLL LQLSSHHHHN NNG----RRK LLLLVYYYDD DEYYATWMMP DDMQQGAVVV AAVADDGYYY YGYDDRRRRL LLI--RRKKV LLLLVYYYNA AEYYATWIIP GDLRRGAIIT KKYADDGYYY YDYDDRRRRL LLP--RRKKL SSSEEEEWAV VN-IEEDLKK LLEHLK--YY GGRRRRIHWL KRILLGEEER RRMMALL--- TTSEEEEWTV VR-FEEEFSS LLECLKGGYY GGKKKKLHWL KHLILGQQER RRMMVLL--- SSSEEEEWAL LP-FEENIVV PPEDLLNNYY GGRRRRLHWL ANVILGAAQQ QQMMALL--- TTSEEEEWAL LP-FEENIVV PPEDLLNNYY GGRRRRLHWL ANVILGAANQ QQMMALL--- SSSEEEEWGL LP-FEENIVV PPEDLLNNYY GGKKKKIHWL DNVILGAANQ QQMMALL--- TTSEEEEWGT TD-VEEDLVV PPDILLAAYY GGRRRRLHWL RHLIFGDDEQ QQLLVFF--- TTSEEEEWGT TR-VEESVLL GGDELLGGYY GGRRRRLHWL RHLLLGAAEQ QQMMALL--- TTSEEEEWGT TN-IEEGLDD PPQILLKKYY GGRRRRLHWL RHLLVGEEEQ QQMMVLL--- SSTEEEEWAA AN-FKKDNPP AAHVEAGGYY GGRRRRIFWW RIILMT---G GGLLIPP--L SSTEEEEWAA AN-FKKDNPP AAHVEAGGYY GGHHHHIHWW RIILMK---G GGLLIPP--L SSTEEEEWAA AN-FRRDNPP AADVEAGGYY GGHHHHLHWW RIILLQ---G GGLLIPP--L SSTEEEEWAA AN-LRRDNPP AADVKAGGYY GGHHHHLYWW RIVLLQ---G GGLLIPP--L SSTEEEEWAA AN-LRRDNPP AADVEAGGYY GGHHHHLYWW HIVLLK---G GGLLIPP--L SSTEEEEWAA AN-LRRDNPP AADVEAGGYY GGHHHHLYWW RIVLLK---G GGLLIPP--L SSTEEEEWAA AN-LRRDNPP AADVEAGGYY GGHHHHLYWW RIVLLK---G GGLLIPP--L SSTEEEEWAA AN-LRRDNPP AADVEAGGYY GGHHHHLYWW RIVLLK---G GGLLIPP--L SSTEEEEWAA AN-VQQNNPP AADVEAGGYY GGHHHHLHWW RIVLMP---G GGHHIPP--L ---------- ---------- ---------- ---------- ---------- ---------- --AIIIISAH HN-RLLTRDD YYPASASSVV AAIIIIT--- ---------- ---------- SSWIIIIQCC CL-YTTTELL MMCLTASSVV HHIIIISCDY MIDLLQ---Q QQAAGAANIL SSTEEEEWGA AK-FAALKMM EEEVQAGGYY GGSSSSLNWW ERIILGEE-G GGLLIPP--L SSTEEEEWGA AK-FAALKMM EEDVQAGGYY GGSSSSLNWW ELVILGKK-G GGLLIPP--L SSTSSSSWGA AT-FTTKDLL QQHVADGGYY GGHHHHLTIL RLRLLGNN-G GGLLLPP--L SSTSSSSWGA AK-FLLQNLL QQHVADGGYY GGHHHHLHYW GIKLLGDD-G GGLLLPP--L SSTSSSSWGA AK-FSSKDLL QQHVADGGYY GGHHHHLHYW GMKILGEE-G GGLLLPP--L SSTSSSSWGA AK-FSSKNLL QQHVADGGYY GGHHHHLHYW GIKILGPP-G GGLLLPP--L SSSSSSSWGA AA-FRRTDLL QQHVQDGGYY GGHHHHLHYW GLKLLGSS-G GGLLLPP--L SSTEEEEWGS SN-IKKKNPP AAHVGEGGYY GGSSSSVHFW SYLILPQQPG GGAALPP--L SSTEEEEWGS SN-IKKKNPP AAHVPEGGYY GGSSSSVHFW THLILPMMPG GGAALPP--L SSILLLLRGG GV-VCCRELL KKCQPEPPVV IICCCCKRY- ---------- ---------- AASEEEEWGA AK-FRRRHPP TTDCDDTTYY GGRRRRLNYW ELFILGDD-G GGLLTPP--L SSSEEEEWGA AN-WRRRKNN VVDLEDSSYY GGRRRRLNYW TLYILGSS-G GGIITPP--L SSDRRRRPDE EI-AFFEESS FFLKKTPPKK PPHHHHVAV- ---------- ---------- TTSSSSSFTG GSYMDDFMLL QQDAEAKKFF GGTTTTIVWL TPKFVPGGA- ---------L TTSSSSSFTG GNYMDDFMLL AADPEAKKFF GGTTTTVVWL TPKFVPGGA- ---------L EELRRRPHDP TTKKGGFFIN MMMVVVLLKK DDSSSWWYED DGGGKKWWWN AEKKIEPEPP EEVRRRPHDP TTKKGGFFVN VVVVVVTTKK DDSSSWWYED DGGGKKWWWQ AERRIDEQPP EEVRRRPHDP VVRRGGFFVG VVVVVVTTTT NNGGSWWREG GGGGKKFFFH VKKKATPEPP EEVRRRPHDP VVRRGGFFVG VVVVVVTTTT NNAASWWREG GGGGKKFFFH AEKKATPEPP EEIRRRPHDP SSKKGGFFCG VVVVVVTTTT NNGGAFFQDD DGGGTTFFFE AKKKITDVPP EELRRRPHDP TTKKGGFFVN CCCVVVLLKK DDSSSWWRDK KDDDKKWWWA VRKKIEPEAA EELRRRPHDP TTKKGGFFMN CCCVVVLLKK DDAASWWRDN NGGGSSWWWH LKKKIDPEPP EELRRRPHDP AARRGGFFVG VVVVVVLLEE DDAASWWRQN NGGGSSWWWG IRKKIEPEPP EEIRRRFHDP SSAAGGFFVG CCCAAASSNN IIFFYNN--- ---------- ----TWVKVV EEIRRRFHDP DDAAGGFFVG CCCAAASSNN IIFFYNN--- ---------- ----TWVKVV EEIRRRFHNP DDAAGGFFVG CCCAAASSTT IIFFYNN--- ---------- ----TWVKVV EEIRRRFHNP DDAAGGFFVG CCCAAASSTT IIFFFNN--- ---------- ----TWAKVV EEIRRRFHNP DDAAGGFFVG CCCAAASSTT IIFFYNN--- ---------- ----TWVKVV EEIRRRFHNP DDAAGGFFVG CCCAAASSTT IIFFYNN--- ---------- ----TWVKVV EEIRRRFHNP DDAAGGFFVG CCCAAASSTT IIFFYNN--- ---------- ----TWVKVV EEIRRRFHNP DDAAGGFFVG CCCAAASSTT IIFFYNN--- ---------- ----TWVKVV EEIRRRFHDP AAAAGGFFVG CCCAAASSTT IIFFYNN--- ---------- ----TWVKVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CCLRRRSHWK NNIIDDYYDV VVVEEEFFSS GGGGSPP--- ---------- ----AVLRKK EEIRRRFHDP DDAAGGLLVG CCCAAASSTT VVFFYEE--- ---------- ----KWAKVV EEIRRRFHNP DDAAGGLLVG CCCAAASSSS IIFFYEE--- ---------- ----KWAKVV EEIRRRFHDP AAKKGGFFVG SSSAAASSNN MMFFFTT--- ---------- ----SWHLAA EEIRRRFHDP AAKKGGFFVG SSSAAASSNN MMFFFTT--- ---------- ----SWHIVV EEIRRRFHDP SSKKGGYYVG SSSAAASSNN MMFFFNN--- ---------- ----TWYIVV EEIRRRFHDP SSKKGGFFVG SSSAAASSNN MMFFFNN--- ---------- ----TWHVVV EEVRRRFHDP SSKKGGYYVG CCCAAASSNN MMFFFTT--- ---------- ----SWHVAA EEVRRRFHEP TTSSAAFFVG CCCAAASSGG IIIIHVVS-- ---------- --TTTHALVV EEVRRRFHEP TTSSAAFFVG CCCAAASSAA IIIIHDDP-- ---------- --KKVQALVV ---------- ---------- ---------- ---------- ---------- ---------- EEIRRRFHNP RREEGGYYVG CCCAAAXXXX XXXXX----- ---------- ---------- EEIRRRFHNP KKKKGGFFVG CCCAAAAAKK VVFFKKKD-- ---------- --EEEAKIDD ---------- ---------- ---------- ---------- ---------- ---------- EEIRRRFWGS NNAAAAFFST TTTAAASSQQ LLIIYDD--- ---------- ---------- EEIRRRCWGE AAHHCCFFTS TTTAAASSQQ LLIIYDD--- ---------- ---------- EGG--PPEII LPKAAAAVPD DDDSSLLDDD FFFLLYYYLS SLWIGGEEER RRYINNFFPP EGG--PPPVV LDKMMMMVPD DDDSSLLDDD FFFLLYYYVS SLWLGGEEER RRYINNHHPP TAADDPPPLL LGGAAAAVPD DDDSSLLDDD FFFLLYYYVS SCWTGGEEER RRYVDDHHPP PKKEEPPPLL LGGAAAAVPD DDDSSMMDDD FFFLLYYYVS SCWTGGEEER RRYVDDRRPP DAADDPPDLL LGGAAAACPD DDDSSLLDDD YYYLLYYYVA ACWLGGEEEH HHYVDDMMPP DPPDDPPPVV LGKAAAAVPD DDDSSMMDDD FFFLLYYYVS SCWTGGDDDL LLYVDDFFPP SEEDDPPPII LPKAAAAVPD DDDSSVVDDD FFFLLYYYVS SCWTGGEEEH HHYVDDFFPP EPPDDPPPLL LDGAAAAVPD DDDSSLLDDD FFFLLYYYVS SCWTGGEEER RRYVDDFFPP QVVPPKKVKK GMPEEEEMPD DDDSSLLDDD FFFLLYYYFS SNWHGGDDDR RRYINNQQPP QVVPPKKVKK GMPEEEEMPD DDDSSLLDDD FFFLLYYYFS SNWHGGDDDR RRYINNKKPP QVVPPKKVKK GMPEEEEMPD DDDSSLLDDD FFFLLYYYFS SNWHGGDDDR RRYIDDQQPP QVVPPKKVKK GMPEEEEMPD DDDSSLLDDD FFFLLYYYFS SNWHGGDDDR RRYVDDQQPP QVVPPKKVKK GLPEEEEMPD DDDSSLLDDD FFFLLYYYFS SNWHGGDDDR RRYIDDQQPP QVVPPKKVKK GLPEEEEMPD DDDSSLLDDD FFFLLYYYFS SNWHGGDDDR RRYIDDQQPP QVVPPKKVKK GLPEEEEMP- ---------- ---------- ---------- ---------- QVVPPKKVKK GLPEEEEMPD DDDSSLLDDD FFFLLYYYFS SNWHGGDDDR RRYIDDQQPP EVVPPKKVKK GMPEEEEMPD DDDSSLLDDD FFFLLYYYFN NNWHGGDDDR RRYIDDKKPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DLLYYVVVAA KGVSSSSLSP PPPFFFFSSD LLLIIIIIFL LS-------- ---------- KVVPPKKVEE GAPEEEEMPD DDDSSLLDDD FFFLLYYYFS SNWHGGDDDR RRYIDDRRPP QVVPPKKVEE GPPEEEEMPD DDDSSLLDDD FFFLLYYYFS SNWHGGDDDR RRYIDDRRPP PVVKKKKVQQ NIPEEEEMPD DDDSSLLDDD FFFLLYYYFV VNWHGGDDDR RRYIDDKKPP SVVEEKKVQQ NFPEEEEMPD DDDSSLLDDD FFFLLYYYFV VNWHGGDDDR RRYIDDKKPP SVVKKKKVEE NIPEEEEMPD DDDSSLLDDD FFFLLYYYFV VNWHGGDDDR RRYIDDKKPP SVVKKKKVEE NIPEEEEMPD DDDSSLLDDD FFFIIYYYFV VNWHGGDDDR RRYIDDKKPP SIIKKKKVRR NIPEEEEMPD DDDSSLLDDD YYYLLYYYLV VNWHGGDDDR RRYIDDAAPP FIIPPKKVSS GAPEEEEMPD DDDSSMMDDD FFFLLYYYVS SCWHGGDDDR RRYIDDLLVV TIIPPKKVEE NAPDDDDMPD DDDSSMMDDD FFFLLYYYVS SCWHGGDDDR RRYIDDKKPP ---------- ---------- ---------- ---------- ---------- ---------- -----QQGEE NEEMMMMMGD DDDSSLLDDD YYYLLYYYFS SNWHGGDDDR RRYIDDAAPP PGGKKDDTGG SVEDDDDMGD DDDSSLLDDD FFFLLYYYVN NCWHGGDDDR RRYIDDEEPP ---------- ---------- ---------- ---------- ---------- ---------- EWWQQAAVAA DGPAAAADID DDDAAAADDD TTTLLWWWIN NSFDGGKKKR RRFIDDHHPP EWWQQAAVAA DGPAAAAKVD DDDSSNNDDD RRRLLWWWVN NTFDGGKKKR RRFIDDHHPP LLTTTGKKIF HRADPP---- ---------- ---AKPPPQQ LISSGGRRRV YVNSYSDDDF LLAAAGRKLY HREPPP---- ---------- ---SEPPPQQ IVSSGGRRRV YINSYSNNNF LLAAAGSRIA RRAPPP---- ---------- ---NTPPPQQ VISSGGRRRV YWNSYSDDDF LLAAAGSHIA RRTPPP---- ---------- ---NAPPPQQ VISSGGRRRV YWNSYSDDDF LLTTTGKEIV KKTPPP---- ---------- ---NTPPPQQ VISSGGRRRV YWNSYSDDDF LLTTTGKRIV SRATPPG--- ---------- -AAKAPPPQQ VISSGGRRRV YFNSYGDDDF LLTTTGKQIV RRAGPP---- ---------- -AATEPPPQQ VISSGGRRRV YFNSYRDDDF HHTTTGSRIV RKAAPP---- ---------- ---APPPPQQ VVSSGGRRRV YFNSYADDDF LLTTTGQFSI VRGGVVQEE- QQELLLEPPP LVVKRPPPQQ ILSSGGRRRL YATSYSDDDF LLTTTGQFSI VKGGVVQEE- QQELLLEPPP LVVKRPPPQQ ILSSGGRRRL YVTSYSDDDF LLTTTGQFSI VKGGVVQEE- QQELLLEPPP LVVKKPPPQQ ILSSGGRRRL YVTSYSDDDF LLTTTGQFSI VKDGVVQDD- QQELLLEPPP LVVKQPPPQQ ILSSGGRRRL YVTSYSDDDF LLTTTGQFSI VKGGVVQEE- QQELLLEPPP LVVKRPPPQQ ILSSGGRRRL YITSYSDDDF LL-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLTTTGQFSI VKGGVVQEE- EEELLLEPPP LVVKRPPPQQ ILSSGGRRRL YITSYSDDDF LLVVVGQFSI VKGGVVQEE- QQELLLEPPP LVVKRPPPQQ ILSSGGRRRI YVTSYSDDDF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLVVVGQFSI LRGGVVTEE- KKDLLLDPPP VVVKKPPPQQ ILSSGGRRRL YVNSYSDDDF LLVVVGQFSI QRGGVVTEE- KKELLLDPPP VVVKIPPPQQ ILSSGGRRRI YVSSYSDDDF LLTTTGQWLI QKGSVVAGG- DDGKKKDVVV PIIQKPPPQQ ILTTGGRRRL YVNSFSDDDF LLTTTGQWLI QKGSVVVKK- DDGEEEDVVV PIIQKPPPQQ ILSSGGRRRL YVNSFSDDDF LLTTTGQWLL QKGSVVKGG- DDGNNNDVVV PIIKSPPPQQ ILSSGGRRRL YANSFSDDDF LLTTTGQWLL QKGSVVKGG- DDGNNNEVVV PIIKSPPPQQ ILSSGGRRRL YANSFSVVVF LLAAAGQWLL QKGSVVVTT- DDDKKKSVVV PVVKRPPPQQ ILSSGGRRRI YVNSFSDDDF LLNNNSQYSV HTESVVKEE- EEK---EAAA LVVKKPPPQQ LLSSGGRRRL YVTSYKDDDF LLNNNSQFSI HSETVVKEE- DDHDDDPAAA LVVKQPPPQQ LLSSGGRRRL YVTSYKDDDF ---------- ---------- ---------- -----PPPAA ILSSGGRRRL YVNSYSDDDF LLTTTGQFAI QRDARRRNN- PPELLLEPPP VLLKRPPPQQ LLSSGGRRRL YVSSFSDDDF LLTTTGQFAI CSDLNNVKKE KKELLLPAAA RVVKRPPPQQ LLSSGGRRRL YVSSYSDDDF ---------- ---------- ---------- ---------- ---------- ---------- QQIIIYEVQV N--------- ---------- ---------- VQSSGGRRRV YFSSLADDD- QQVVVYETQV N--------- ---------- ---------- VSSSGGRRRL YYSSLADDD- FPELLNNNAA ANN----PPP SGLEIIIIIE EVVDDGE-SH QQQRSSDASS SDDSSSYCCC FP-LLNNNVV VNN----PPP EGLELLLLLE EVVDDGR-AH QQQRWWDASS SDDSSSFCCC FPDVVHHHAA AGG----PPP DGLTLLLLLD DVVEEPDGAH QQQREEDCSS SDDSSSFCCC FPDVVNNNVV VGG----GGG NGLELLLLLD DVVSSPDGAH QQQREEDCSS SDDSSSFCCC FPGRRNNNVV VGG----EEE NGLTLLLLLD DVVDDPAGSH QQQREEDCSS SDDSSSFCCC FPEIIDDDAA AGG----PPP NGIEFFFFFK KLLEEPKGPH QQQRQQDCSS SDDSSSYCCC FPDIIDDDVV VNN----PPP DGMQFFFFFN NVVDDGE-VH QQQRQQDASS SDDSSSYCCC FPVIIEEEAA ADD----PPP GGLSLLLLLG GTTEEGDGPH QQQREEDSSS SDDSSSYCCC F-PLLLLLQQ QVVDVVVVVV NGLKLLLLLN NVVDDGKEAH EEERPPDCSS SDDIIIWIII F-PLLLLLQQ QIIDVVVAAA NGLKLLLLLN NVVDDGKEAH EEERPPDCSS SDDIIIWIII F-PLLLLLQQ QIIDVVVVVV KGLKLLLLLN NVVDDGKEAH EEERPPDCSS SDDIIIWLLL F-PLLLLLQQ QIIDVVVVVV KGLTLLLLLN NVVDDGKEAH EEERPPDCSS SDDIIIWLLL F-PLLLLLQQ QVVDVVVVVV KGLKLLLLLN NVVDDGKEAH EEERPPDCSS SDDIIIWIII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- F-PLLLLLQQ QVVDVVVVVV KGLKLLLLLN NVVDDGKEAH EEERPPDCSS SDDIIIWIII F-PLLLLLQQ QIIDVVVVVV KGLKLLLLLN NVVDDGKEAH EEERPPDCTT TDDIIIWLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- F-PMMLLLQQ QIIDVVVEEE KGLKLLLLLN NVVDDGKEAH EEERPPDCSS SDDIIIWVVV F-PLLLLLQQ QIIDVVVKKK KGLKLLLLLN NVVDDGKEAH EEERPPDCTT TDDIIIWIII F-PLLLLLQQ QIIDVVVEEE KGLKIIIIIN NVVDDGAEAH EEERPPDCTT TDDIIIWIII F-PLLLLLQQ QIIDVVVEEE NGLKIIIIIN NVVDDGAEAH EEERPPDCTT TDDIIIWIII F-PLLIIIQQ QIIDVVVEEE KGLSIIIIIN NVVDDGDEAH EEERPPDCTT TDDIIIWIII F-PIIIIIQQ QIIDGGGEEE KGLTIIIIID DVVDDGDEAH EEERPPDCTT TDDIIIWIII FGQLLLLLQQ QIIDVVVEEE KGLSIIIIIN NVVDDGAEAH EEERPPDCTT TDDIIIWIII F-PHHVVVQQ QVVNIIIEEE SGMEIIIIID DIIDDGKIAH EEERPPDCTT TDDIIIWIII F-PNNLLLQQ QIIDVVVIII TGMVIIIIIN NIIDDGKVAH EEERPPDCTT TDDIIIWIII F-PVVLLLQQ QIIDVVVEEE KGLTVVVVVN NVVDDGKEAH DDDRPPDSTT TDDIIILAAA F-PMMVVVQQ QLLDIIIEEE NGMKLLLLLN NVVDDGGEPH EEER------ ---------- F-PMMVVVLL LIIDVVVVVV NGISLLLLLD DVVDDANEPH EEERPPDCTT TDDIIIWLLL ---------- ---------- ---------- ---------- ---------- ---------- -----AAAQQ QYYLKKKNNN WDKELLLLLD DVVDDYELAH IIIRGGALYY YSS------- -----EEEQQ QFFLKKKYYY WDKELLLLLQ QIIDDYAEPH QQQRGGALYY YGGPPPAGGG Y------ Y------ YSVVK-- YSVV--- YSVV--- Y------ F------ YS----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ADAA--- ------- ------- DNRRLAE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMAKKKQPTT PPPCCCTVPP GGTTAAALAA LLPPTTQLSS LSPRRKAAYE AWWTSSAIQV gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- --------MG RAAPLPPLNN gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ASSPPPRRRS SKKTTRRVVV PGGLLEISSV VKQQQVVPPP SQQAAPPPGK AVLLLIIAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----AAARA FTLLLQQSSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----GGGEE TAQQQPPWWW ---------- ---------- ---------- ---------- -----QQQCL QTNNNTTEEE ---------- ---------- ---------- ---------- ---------- ---------- TTTPPPHHHP PLASSPPHHH PRRVVLTLLR RYRRRTINNN VPPPRRRRSL HIMMMEEGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMMAATTT ---------- ---------- ---------- ---------- ---------- --MMMGGTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----KKKRE ---------- ---------- ---------- ---------- ---------- -----KKKFI PSMMMHHFFF ---------- ----IIFDDP PFPSSKKAMK APPPDDAYAC LYTGGGGTTI NNADDDAVVV ---------- ----MMLDDP PFPTTRRAMR APPPDDAYAA LYVGGGGTTV NNPDDDAVVV ---------- ------MDDP PFASSEEAMQ APPAEEAYLL LSPDDDDFF- --PDDDAVVI ---------- ------MDDP PFASSKKAME APPANNAYLL LSPDDDDFF- --PDDDAVVI ---------- ------LDDP PFPSSKKAME GPPVKKAFLM LSPDDDDAA- --PDDDAVVV ---------- ----MMWDDP PFPSSRRAAK APPPTTAYAM FDPEEEERR- --PDDDAVVV ---------- ----MMWDDP PFPSSRRAVK APPAKKAYVR LNPMMMMAAG --PDDDCVVV ---------- ----MMWDDP PFPSSKKAMQ APPRRRGYAL LDPGGGGRR- --PDDDGVVL ---------- ----CC-GGP PYTPPEEMK- GPPREEVYPC IYRNNNNTTT EEPDDDATTV ---------- ---------- --------M- GPPREEVYPC IYRNNNNTTI EEPDDDATTV APPPAARGGL PG--CC-GGP PYSPPEEMK- GPPREEVYPC IYGNNNNTTI EEPDDDATTV ---------- ---------- -------MK- GPPREEIYPC IYRNNNNTTI EEPDDDATTV ---------- ----CC-GGP PYTPPEEMK- GPPREEVYPC IYRNNNNTTT EEPDDDATTV SVVVAAQPPR PIAACC-GGP PYTPPEEMK- GPPREEVYPC IYRNNNNTTT EEPDDDATTV ---------- ----CC-GGP PYTPPEEMK- G--------- ---------T EEPDDDATTV ---------- ----CC-GGP PYTPPEEMK- GPPREEVYPC IYRNNNNTTT EEPDDDATTV WFFFLLSGGL WQEECC-GGP PYTPPEEMK- GPPREEVYPC IYRNNNNTTT EEPDDDATTV ELLLHHTYYT LVFFCC-GGP PYTPPEEMK- GPPREEVYPC IYRNNNNTTT EEPDDDATTV ---------- ----CC-GGP PYTPPEEMK- GPPREEVYPC IYRNNNNTTT EEPDDDATTV GAAAAAAVVT AAAACCTGGP PYTPPEEMEK GPPRKKVYTC VYNGGGGTTI NNLDDDATTV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----CC-GGP PYSPPDDMK- GPPREEVYPC IYRSSSSTTI NNPDDDATTV TVVVLLDHHV VNEENNCGGP PYSPPEEMS- GPPRSSIYTA VYAGGGGTTI EEPDDDATTV TVVVLLQHHV VSEEQQCGGP PYSPPEEMS- GPPRTTIYTA VYAGGGGTTI EEPDDDATTV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RRQGGP PYTPPAAMS- GPPSKKIYTA VYTGGGGTTI DDPDDDATTV ---------M AAAACCGGGP PYTPPEEMEK GPPRKKLYTC VYNGGGGTTI NNPDDDGTTV ---------- MSPPCC-GGP PYSPPDDIK- GPPREELFTA P------NNA DDPDDDFTTV ---------- MP--CC-GGP PYSPPDDIK- GPPREELFTA P------HHR DDPDDDFTTV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----EECGGP PYTPPDDVRN GPPVKKLYVC VQPNNNNLLE EEGDDDATTV ---------- ---------- -------MRS GPPRKKLYVT VQPNNNNLLE PPGDDDSTTV ---------- -------MMP PLT--DDLIS LDDDFFYFNW LHGDDDDIIQ YYITTTKNNP -------AAA AG--LLRAAD DTQSSYYPKI TGGQEEVYWT LGVEEEEGGG DDQDDDVTTI FAAALLRAAV SGLLAAGAAD DTASSYYKKI TGGQDDVYWT LGAEEEEGGG DDQDDDVTTV DDKKETKIVV KVELYYNNLL HHHHFGNNNN ACSSSCC--P PPPNGGGKKP NERRFFIIVV DDKKPTKVII KLDLYYGGLL HHHHFGNNNN ACSSSCC--P PPPNAAAKKP FERRYYIIVV DDGGSTKIVV TVTMNNGGFF HHHHFGNNNN ACSSSSS--P PPPLTTTHHA FERRFFIIII DDGGPTQIVV TVTMNNGGFF HHHHFGNNNN ACSSSSS--P PPPLAAAHHA FERRYYIIII DDTTEKQIVV QLIMNNGGFF HHHHFGNNNN ACSSSSS--P PPPLTTTHHA FERRYYIIII DDAAPRSIVV QVAMHHGGLL HHHHFGNNNN ACSSSCC--P PPPNAAAHHP HERRYYVVVV DDQQSTQVVV VTDMYYGGLL HHHHFGNNNN ACSSSCC--P PPPNAAAHHP HERRYYVVVV DDDDGTQIVV RVEMNNAALL HHHHFGNNNN ACAAACC--P PPPYAAAHHP HERRYYIIVV DDKKPQQVII RLPMYYKKLL HHHHSGNNNN TCSSS----- ----FFFDDS TSRNKKIILL DDKKPHQVII RLPMHHKKLL HHHHSGNNNN TCSSS----- ----FFFDDS TSRDKKIILL DDKKPQQVII RLPMNNRRLL HHHHSGNNNN ACSSS----- ----FFFDDS TSRTKKMMLL DDKKPQQVII RLPMHHKKLL HHHHSGNNNN TCSSS----- ----YYYDDI TARTKKVVLL DDKKPQQVII RLPMNNKKLL HHHHSGNNNN TCSSS----- ----FFFDDS TSRTKKVVLL DDKKPQQVII ---------- ---------- ---------- ---------- ---------- DDKKPQQVII RLPMNNKKLL HHHHSGNNNN TCSSS----- ----FFFDDS TSRTKKVVLL DDKKPQQVII RLPMNNKKLL HHHHSGNNNN TCSSS----- ----FFFDDS TSRTKKVVLL DDKKPQQVII RLPMYYKKLL HHHHSGNNNN TCSSS----- ----FFFDDS TSRNKKVVLL DDKKPQQVII RLPMNNKKLL HHHHSGNNNN TCSSS----- ----FFFDDS TSRTKKVVLL DDKKPQQVII RLPMNNKKLL HHHHSGNNNN TCSSS----- ----FFFDDS TSRTKKVVLL DDSSPTQVII RLPVHHGGLL HHHHSGNNNN SCSSS----- ----HHHDDP SKRRFFIILL ---------- ---MNNNNLL HHHHSGNNNN TCSSS----- ----YYYDDA SVRNKKIILL DDKKPSQVII RLPMNNNNLL HHHHSGNNNN TCSSS----- ----YYYDDS SVRNKKIILL DDSSPTKVII RLPVYYGGLL HHHHTGNNNN SCSSS----- ----HHHDDP SERRFFIIAA DDNNPTKVII RLPVYYGGLL HHHHTGNNNN SCSSS----- ----HHHDDP SQRRFFIIVV ---------- ---MFFGGLL HHHHSGNNNN SCSSS----- ----HHHDDA SDRRYYVVLL DDSSPSSVII RLPMFFGGLL HHHHSGNNNN SCSSS----- ----HHHDDA SDRRYYVVLL DDNNPTQVII RLPVHHGGLL HHHHSGNNNN ACSSS----- ----HHHDDP SSRRFFIILL DDEEDTQVII RVDVHHGGVV HHHHTGNNNN ACSSS----- ----HHHKKP TKRSHHIIVV NNEEETQIII RVDVNNGGVV HHHHTGNNNN ACSSS----- ----HHHKKP TKRSHHIIVV ---------- ---------- ---------- ---------- ---------- ------VVPP DDAAPTQVII RTYTSSHHLL HHHHSGNNNN TCSSSFFVVP PPP-GGGKKE VTRDRRVVLL DDEEPTQIVV RTFTRRGGLL HHHHSGNNNN ACSSSYYVVD DDDESSSKKT VKRDRRVVLL RRQQFLSVLL DGPVVVEEEE LLDDSQTTTT PRLLL----- -------KKR VGGPQQLLQQ DDGGATQVII SVSVGGRRAA HHHHGGSSSS A--------- ---------- -DRRFFWWTT DDKKPQKVVV TLSVGGRRAA HHHHSDTTTT D--------- ---------- -DRRYYWWAA PRSSSSSRRR IIIIDDTPPK IIIKKKKVII EEEEKKKVSY SSRRLHVHPP AAAAIYSSSA PRSSSSSRRR IIIVDDTPKA VVVKKKKIVV EEEEVVGRTY TTKKYHVHPP AAAAIYSSSA PRSSSSSRRR IVVIDDTPPR IIIKKKKIII EEEDLLAKTY SSRRPHVHPP GGGGIYSSST PRSSSSSRRR IIIIDDTPPK IIIKKKKIII EEEEFFKKTY SSRRPHIHPP GGGGIYSSST PRSSSSSRRR IIIVDDV-PK IIIKKKKIII EEEEFFAKTY SSRRPHIHPP GGGGIYSSST PRSSSSSRRR IIILDDTPPF LLLKKKKVII EEEEAAERTY SSRRPHVHPP GGGGIYTTTA PRSSSSSHHH IIILDDTPPK VVVKKKKVII DDDNAAERTY AARRPHVHPP GGGGIYSSSA PRSSSSSRRR IIIVDDTPPR IIIKKKKVII EEEEHHRRTY SSRRPHIHPP GGGGVYSSSA PMSSSSSRRR IVVVDDVSPK LLLKKKKVII EEESQQAKCV SSNNTHSHAA GGGGEVVVVN PISSSSSRRR IVVVDDVSPK LLLKKKKVII EEENHHAKCL GGNNLHSHAA GGGGEVIIIS PMSSSSSRRR IVVVDDVSPK LLLKKKKVII EEEEHHAKCL GGYYVHSHAA GGGGEVIIIS PISSSSSRRR IVVVDDVTPK LLLKKKKVII EEEKHHTKCL GGFFFHSHPP GGGGEVVVVS PISSSSSRRR IVVVDDVSPK LLLKKKKVII EEEEHHAKCL AAFFLHSHAA GGGGEVIIIS ---------- ---------- ---------- ---KHHAKCL AAFFLHSHAA GGGGEVIIIS PISSSSSRRR IVVVDDVSPK LLLKKKKVII EEEKHHAKCL AAFFLHSHAA GGGGEVIIIS PISSSSSRRR IVVVDDVSPK LLLKKKKVII EEEKHHAKCL AAFFLHSHAA GGGGEVIIIS PISSSSSRRR IVVVDDVTPK LLLKKKKVII EEEKHHEKCL GGTTPHSHPP GGGGEVIIIS P--------- ---------- ---------- ---------- ---------- ---------- PISSSSSRRR IVVVDDVSPK LLLKKKKVII EEEKHHAKCL AAFFLHSHAA GGGGEVIIIS PLSGGGGRRR VVVVDDTTPS LLLKKKKVVV EEEEAAENIL GGFFPHSHAA GGGGDIIIIS PISSSSSRRR IVVVDDVTPR IIIKKKKTVV EEEYFFWKCL AANNLHSHGG GGGGEIIIIS PISSSSSRRR IVVVDDVSPR IIIKKKKTVV EEEYFFWKCL AANNPHSHGG GGGGEIIIIS PVSGGGGRRR IVVIDDTTPS LLLKKKKVVV DDDAIIQKTL AAYYPHSHAA GGGGELIIIS PVSGGGGRRR VVVIDDTTPS LLLKKKKVVV EEEESSTKTL AAYYPHSHAA GGGGEIIIIS PISGGGGRRR IAAIDDTEPS LLLKKKKYVV DDDKAAEKTL AAYYPHAHAA GGGGEIVVVS PISGGGGRRR IAAIDDTEPS LLLKKKKYVV DDDKAADKTL AAFFPHAHTT GGGGEIVVVS PLSGGGGRRR VVVVDDTKPA LLLKKKKVVV EEEEAAEKTL GGFFPHSHAA GGGGEIIIIS PNSDDDDRRR IIIINNVN-Y LLLHHHHTII EEESHHSLNL SSFFPHSHAA GGGGNIIIIS PNSDDDDRRR IVVINNVN-Y LLLHHHHTII EEESHHALNL SSFFPHSHAA GGGGNIIIIS RSSGGGGVVV EKKVFFVG-- ---------- ---------- ---------- ---------- PNSDDDDRRR IVVIDDTTPK LLLKKKKVII EEE-LLKGAC TTAAPHTHPP GGGGNIIIIS PNSDDDDFFF IIILDDVTPE IIIKKKKTII DDD-LLKSHV TTAAPHTHAA GGGGNIIIIS LDGKKKKRRR LVVTTTSYAQ FFFPPPP--- ----IIKFLL AAIISHADPP TTTTALQQQD GDTNNNNRRR IIIFDDVSPK LLLKKKKTII DDD-KKDSGV VVGGPHFFPP SSSSMMTTTG GDTSSSSKKK IVVFDDVSPV LLLKKKKTII TTT-EEKSGV VVGGPHLYPP RRRRMLTTTG AANEE-EEGG GLMMDDDHHH HSFFELLGGK KKWWEERRRG YY-------- --------LA AAGPP-DEGG GFLLDDDHHH HTFFEIIGGR RRWWEERRRG YY-------- --------FA TTGAAGDDGP GFIIDDDCCC CTFFDLLGGR RRWWEERRRG DD-------- --------KH TTGGGGDNGP GFIIDDDCCC CTFFELLGGR RRWWEERRRG TT-------- --------LH TTGGGGDDGP GFIIDDDCCC CTFFELLGGR RRYYEERRRG TT-------- --------KH AANAA-EKGG GAMMDDDAAA ASFFELLGGR RRWWEERRRG YY-------- --------FA AASPP-EEGG GFIIDDDHHH HNLLELLGGR RRWWEERRRG YY-------- --------LH AASPP-EDGG GFVVDDDHHH HSFFDLLGGR RRWWEERRRG QQ-------- --------LA NNGDD-LNGG SVLLDDDGGG GTFFEKKGGT TTWWEEGGGG PP-------- --------MG SSGDD-PNGG GVLLDDDGGG GTFFEKKGGT TTWWEEGGGG PP-------- --------MG SSGDD-SNGG GVLLDDDGGG GTFFEKKGGT TTWWEEGGGG PP-------- --------MG SSGDD-PNGG GVLLDDDGGG GTFFEKKGGT TTWWEEGGGG PP-------- --------LG SSGDD-VNGG GVLLDDDGGG GTFFEKKGGT TTWWEEGGGG PP-------- --------SG SSGDD-VNGG GVLLDDDGGG GTFFEKKGGT TTWWEEGGGG PP-------- --------LG SSGDD-VNGG GVLLDDDGGG GTFFEKKGGT TTWWEEGGGG PP-------- --------LG SSGDD-VNGG GVLLDDDGGG GTFFEKKGGT TTWWEEGGGG PP-------- --------LG SSGDD-PNGG GVLLDDDGGG GTFFEKKGGT TTWWEEGGGG PP-------- --------MG ---------- ---------- ---------- ---------- ---------- ---------- SSGDD-VNGD GLVVLLLPPP PRLLESSGG- ---------- ---------- ---------- SSGDD-KNAG NFLLLLLDDD DEFFNKKGGR RRGGSSLLLF SS-------- --------KE SSGDD-PNGG GVLLDDDGGG GTFFEKKGGN NNWWEEGGGE PP-------- --------FG SSGDD-PNGG GVLLDDDGGG GTFFEKKGGN NNWWEEGGGE QQ-------- --------FG SSGDD-KNAG NFLLLLLDDD DDFFNKKGGR RRWWEEGGGH LL-------- --------FG SSGDD-KNAG NFLLLLLDDD DEFFNKKGGR RRWWEEGGGH LL-------- --------FG SSGDD-ENAG NFLLLLLDDD DDFFNKKNNR RRWWEEGGGH LL-------- --------FG SSGDD-ENAG NLLLLLLDDD DDFFNKKNNR RRWWEEDDDI LL-------- --------YG SSGDD-KNAG NFLLLLLDDD DEFFNKKGGR RRWWEEGGGH LL-------- --------FG SSGEE-ATPG NLLLDDDGGG GTFFEKKGGT TTWWPPEEEK PP-------- --------FN SSGEE-ASPG NLLLDDDGGG GTFFEKKGGT TTWWPPGGGK PP-------- --------FN ---------- ---------- ---------- ---------- ---------- ---------- SSGDD-ANAG -FVVFFFDDD DNFFEVVGGT TTWWSSDDDR LL-------- --------CG SSGDD-AYAG -FIIFFFDDD DDFFNIIGGT TTWWTTDDDK LL-------- --------CG DDNEE-SVPL NIQQSSSKKK KENNGSSAAK KKGGEEQQQF II-------- --------LQ GGNDD-DGGT AVEENNNDDD DGEEYAATTY YYWWMMAAAD QQGAAVVVVV AAAAADDGYG GGNNN-KGGT AVEETTTNNN NGEEYAATTH HHWWIIDDDG RRGAAIIITT KKKAADDGYD YYYFWWNNNL LNEVVEWWPP TIDG---HHK KDD--IHWDL KKKILLEEEE NAL----ERR YYYFWWNNNL LSGVIEWWPP CFEG---CCK KEEGGLHWDL KKRLILQEEE HVL----ERR YYYFWWNNNL LRDYVEWWPP QFNG---DDL LAANNLHWDL AARVILAQQQ HAL----ERR YYYFWWNNNL LRDYVEWWPP QFNG---DDL LSSNNLHWDL AARVILANNN HAL----ERR YYYFWWNNNL LRDYVEWWPP QFNG---DDL LSSNNIHWKL DDKVILANNN HAL----ERR YYYGWWHHHL LYDTVEWWPP MVDG---IIL LGGAALHWDL RRRLIFDEEE HVF----ERR YYYFWWHHHL LYDTLEWWPP MVSG---EEL LAAGGLHWDL RRRLLLAEEE YAL----ERR YYYFWWHHHL LYDTVEWWPP MIGG---IIL LNNKKLHWDL RRRLLVEEEE HVL----ERR YYYFWYQQQP PHNVVEWWPP VFDGFFFVVA A--GGIFWDW RREILM---- DIP----ERR YYYFWYQQQP PHNIVEWWPP VFDGFFFVVA A--GGIHWDW RREILM---- DIP----ERR YYYFWYQQQP PHNVIEWWPP VFDGFFFVVA A--GGLHWDW RREILL---- DIP----ERR YYYFWYQQQP PHNVIEWWPP VLDGFFFVVA A--GGLYWDW RREVLL---- DIP----ERR YYYFWYQQQP PHNVIEWWPP VLDGFFFVVA A--GGLYWDW HHEVLL---- DIP----ERR YYYFWYQQQP PHNVIEWWPP VLDGFFFVVA A--GGLYWDW RREVLL---- DIP----ERR YYYFWYQQQP PHNVIEWWPP VLDGFFFVVA A--GGLYWDW RREVLL---- DIP----ERR YYYFWYQQQP PHNVIEWWPP VLDGFFFVVA A--GGLYWDW RREVLL---- DIP----ERR YYYFWYQQQP PHNVIEWWPP VVNGFFFVVA A--GGLHWDW RREVLM---- DIP----ERR ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----ISSSS LRTGSSSAAA A--SST---- ---------- ---------- RRRHLYEEEN NWGLWIQQSS FYTGAAALLA A--SSSCDNY MMVDLL---- DGAPPIICRR YYYFWYQQQP PHNVIEWWPP AFLGFFFVVA A--GGLNWDW EERIILE--- DIP----ERR YYYFWYQQQP PHNVIEWWPP AFLGFFFVVA A--GGLNWDW EERVILK--- DIP----ERR YYYFWYQQQP PHNTISWWPP AFKGFFFVVD D--GGLTIQL RRERLLN--- TLP----ERR YYYFWYQQQP PHNTISWWPP AFQGFFFVVD D--GGLHYSW GGEKLLD--- KLP----ERR YYYFWYQQQP PHKTISWWPP AFKGFFFVVD D--GGLHYSW GGEKILE--- TLP----ERR YYYFWYQQQP PHKTISWWPP AFKGFFFVVD D--GGLHYSW GGEKILP--- TLP----ERR YYYYWYQQQP PHKTISWWPP AFTGFFFVVD D--GGLHYDW GGEKLLS--- TLP----ERR YYYFWYQQQP PRNVIEWWPP HIKGFFFVVE E--GGVHFEW SSKLILQPPP LLP----ERR YYYFWYQQQP PRNIIEWWPP HIKGFFFVVE E--GGVHFEW TTKLILMPPP RLP----ERR ---------- -----LRRPP TVRDEEEQQE E--PPKRY-- ---------- ---------- YYYYWYQQQP PFNVVEWWPP LFRGYYYCCD DRRTTLNYRW EEEFILD--- DTP----ERR YYYFWYQQQP PFDVVEWWPP KWRGWWWLLD DMMSSLNYKW TTTYILS--- DTP----ERR LLLNHNNNNG GREKERPPPP MAESSSSKKT TGGPPVAVL- ---------- ---------- YYYIRALLLI IKNVLSFFWW MMFGQQQAAA AMMKKIVWDL TTQKFVGAAA P------ERR YYYVRALLLP PKNLVSFFWW MMFGKKKPPA AMMKKVVWDL TTQKFVGAAA P------ERR RRLHKLGIIV VLKDDLSSIW WWWWYYYYY- EGWNNKVIII PPAAAEPLEE GG-NNNNLPP RRLHKLGVVV LTKDDLSSIW WWWWYYYYY- EGWQQRVIII EEAAAQPFEE GG-PPPPLPP RRAHREGVVV VTTNNLEGIW WWWWRRRRR- EGFHHKTAAI PPAAAEPATT AADEEEELPP RRAHREGVVV VTTNNLEAIW WWWWRRRRR- EGFHHKTAAI PPPPPEPAPP KKEKKKKLPP RRAHKDGCCV VTTNNLQGIF FFFWQQQQQK DGFEEKTIII DDPPPVPADD AADDDDDLPP RRAHKAGVVV ILKDDLSSIW WWWWRRRRR- DDWAAKVIII PPAAAEAADD PPDQQQQLPP RRAHKAGMMV VLKDDLSAIW WWWWRRRRR- DGWHHKVIII PPAAAEPASS EEDQQQQLPP RRAHRTGVVV VLEDDLSAVW WWWWRRRRR- QGWGGKVIII PPAAAEPAEE PPDQQQQLPP RRLHATGVVA LSNIIQRFKN NNNE------ -------TTS VVEEEKVIQQ VVPSSSSKKK RRLHATGVVA LSNIIQRFKN NNNG------ -------TTS VVEEEKVIQQ VVPSSSSKKK RRLHAAGVVA LSTIIQRFKN NNNG------ -------TTS VVEEEKVIQQ VVPPPPPKKK RRLHAAGVVA LSTIIQRFKN NNND------ -------TTS AAQQQKVIQQ VVPPPPPKKK RRLHAAGVVA LSTIIQRFKN NNNG------ -------TTS VVEEEKVIQQ VVPPPPPKKK RRLHAAGVVA LSTIIQRFKN NNNG------ -------TTS VVEEEKVIQQ VVPPPPPKKK RRLHAAGVVA LSTIIQRFKN NNNG------ -------TTS VVEEEKVIQQ VVPPPPPKKK RRLHAAGVVA LSTIIQRFKN NNNG------ -------TTS VVEEEKVIQQ VVPPPPPKKK RRLHASGVVA LSTIIQRFKN NNNG------ -------TTS VVEEEKVIEE VVPPPPPKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRIHINDDDE VFSGGRGGDP PPPA------ -------AAV LLKKKRKLDD LLYYYYYAVV RRLHAAGVVA LSTVVFRFKE EEED------ -------KKA AAEEEKVIKK VVPSSSSKKK RRLHADGVVA LSSIIFRFKE EEED------ -------KKA AAEEEKVIQQ VVPSSSSKKK RRLHKDGVVA LSNMMIRFKT TTTD------ -------SSS HHEEELAIPP VVKPPPPLKK RRLHKDGVVA LSNMMIRFKT TTTD------ -------SSN HHEEEIVISS VVEPPPPLKK RRLHKDGVVA LSNMMIRFKN NNND------ -------TTS YYEEEIVISS VVKPPPPLKK RRLHKDGVVA LSNMMIRFKN NNND------ -------TTS HHEEEVVISS VVKPPPPLKK RRLHKDGVVA LSNMMVRFKT TTTD------ -------SSS HHEEEVAISS IIKPPPPLKK RRLHSEAVVA LSGIIFRIPV VVVESSSSS- -----T-TTA AATTTLVAFF IIPSSSSKKK RRLHSEAVVA LSAIIFRIPD DDDKPPPPP- -----K-VVT AASSSLVATT IIPSSSSKKK ---------- ---------- ---------- ---------- ---------- ---------- RRLHENGVVA FXXXXXXX-- ---------- ---------- ---------- --------QQ RRLHKAGVVA LAKVVFHFKK KKKDDDDDD- -----EFEEK KKVVVIDIPP GGKLLLLVDD ---------- ---------- ---------- ---------- ---------- ---------- RRPWANASSA LSQLLWLIED DDDA------ ---------- --------EE WWQAAAAKAA RRAWHNCTTA LSQLLWLIED DDDE------ ---------- --------EE WWQAAAAKAA EILKKPPPVD IIDDDIISDD KKFFFLYLSL LWGEEYDINN FKLLTGGGGK VVLLGGGFRA PVLKKDPPVD IIDDDIISDD RRFFFLYVSL LWGEEYDINN HQLLAGGGGR VVIIGGGYRE PLLQQGPPVD IIDDDLLSDD RRFFFLYVSC CWGEEYDVDD HNLLAGGGGS VVIIGGGARA PLLQQGPPVD IIDDDLLSDD RRFFFLYVSC CWGEEYDVDD RKLLAGGGGS VVIIGGGART DLLKKGPPVD IIDDDLLSDD KKYYYLYVAC CWGEEYDVDD MNLLTGGGGK VVIIGGGVKT PVLKKGPPVD IIDDDLLSDD RRFFFLYVSC CWGDDYDVDD FELLTGGGGK VVIIGGGVRA PILKKPPPVD IINNNLLSDD RRFFFLYVSC CWGEEYDVDD FNLLTGGGGK VVIIGGGVRA PLLKKDPPVD IINNNLLSDD RRFFFLYVSC CWGEEYDVDD FNHHTGGGGS VVLLGGGVKA VKGWWMPGID IILLLLLSDD RRFFFLYFSN NWGDDYDINN QKLLTGGGGQ IILLGGGIRG VKGWWMPGID IILLLLLSDD RRFFFLYFSN NWGDDYDINN KKLLTGGGGQ IILLGGGIKG VKGWWMPGID IILLLLLSDD RRFFFLYFSN NWGDDYDIDD QRLLTGGGGQ LLLLGGGIKG VKGWWMPGID IILLLLLSDD HHFFFLYFSN NWGDDYDVDD QRLLTGGGGQ LLLLGGGIKD VKGWWLPGID IILLLLLSDD RRFFFLYFSN NWGDDYDIDD QRLLTGGGGQ LLLLGGGIKG VKGWWLPGID IILLLLLSDD RRFFFLYFSN NWGDDYDIDD QRLL------ ---------- VKGWWLPGI- ---------- ---------- ---------- ---------- ---------- VKGWWLPGID IILLLLLSDD RRFFFLYFSN NWGDDYDIDD QRLLTGGGGQ LLLLGGGIKG VKGWWMPGID IILLLLLSDD RRFFFLYFNN NWGDDYDIDD KRLLVGGGGQ IILLGGGIKG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VAKFFGSNFP AAWWWIIFDD LLLLLIIFLS S--------- ---------- ---------- VEGWWAPGID IILLLIISDD RRFFFLYFSN NWGDDYDIDD RNLLVGGGGQ IILLGGGIRG VEGWWPPGID IILLLIISDD RRFFFLYFSN NWGDDYDIDD RNLLVGGGGQ IILLGGGIRG VQNWWIPGID FFLLLIISDD RRFFFLYFVN NWGDDYNIDD KNLLTGGGGQ LLVVGGGIKG VQNWWFPGID FFLLLIISDD RRFFFLYFVN NWGDDYNIDD KNLLTGGGGQ VVAAGGGIKG VENWWIPGID FFLLLIISDD RRFFFLYFVN NWGDDYNIDD KNLLTGGGGQ IIVVGGGLKG VENWWIPGID FFLLLIISDD RRFFFIYFVN NWGDDYNIDD KNLLTGGGGQ IIVVGGGLKG VRNWWIPGID FFVVVIISDD RRYYYLYLVN NWGDDYNIDD AKLLAGGGGQ VVAAGGGLKG VSGWWAPAID IILLLIISDD RRFFFLYVSC CWGDDYDIDD LKLLNSSSSQ VVIIGGGVTE VENWWAPAID IILLLIISDD RRFFFLYVSC CWGDDYDIDD KNLLNSSSSQ VVIIGGGISE ---------- ---------- ---------- ---------- ---------- ---------- GENGGEGGMD IILLLIISDD RRYYYLYFSN NWGDDYDIDD ANLLTGGGGQ VVLLGGGIRD TGSGGVGGID IIIIIIISDD RRFFFLYVNC CWGDDYDIDD ENLLTGGGGQ LLLLGGGISD ---------- ---------- ---------- ---------- ---------- ---------- VADIIGIPPD IISSSIIADD QQTTTLWINS SFGKKFDIDD HKQQIYYYYE KKIIDDRV-- VADIIGVPPD IISSSIISDD SSRRRLWVNT TFGKKFDIDD HHQQVYYYYE KKIIGGAV-- DPP------- ---------A LLLAQQESRR RRRRGGRRRR VYVTTNSSLL STTWWQQFFY PPP------- ---------S AAAAQQSSRR RRRRGGRRRR VYITTNSSLL SSSWWQQFFY PPP------- ---------N FFFGQQESRR RRRRGGRRRR VYWTTNSSLL STTWWQQFFY PPP------- ---------N FFFGQQESRR RRRRGGRRRR VYWTTNSSLL STTWWQQFFY PPP------- ---------N FFFGQQESRR RRRRGGKRRR VYWTTNSSLL STTWWQQFFY TPP------- --------AK LLLGQQESRR RRRRGGRRRR VYFTTNSSLL GAAVVQQFFY GPP------- --------AT LLLGQQESRR RRRRGGRRRR VYFTTNSSLL RAAWWQQFFY APP------- ---------A LLLGQQESRR RRRRGGRRRR VYFSSNSSLL ASSWWQQFFY GVVVLEETCC QPPEPPPLVK IIIGQQQSLL LLLLGGKRRR LYATTTSSLL SDDWWQQFFY GVVVLEETCC QPPEPPPLVK VVVGQQQSLL LLLLGGKRRR LYVTTTSSLL SAAWWQQFFY GVVVLEEKSS QPPEPPPLVK VVVGQQQSLL LLLLGGKRRR LYVTTTSSLL SAAWWQQFFY GVVVLDEDSS QPPEPPPLVK VVVGQQQSLL LLLLGGKRRR LYVTTTSSLL SAAWWQQFFY GVVVLEEKSS QPPEPPPLVK VVVGQQQSLL LLLLGGKRRR LYITTTSSLL SAAWWQQFFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GVVVLEEKSS QPPEPPPLVK VVVGQQQSLL LLLLGGKRRR LYITTTSSLL SAAWWQQFFY GVVVLEEKSS QPPEPPPLVK VVVGQQQSLL LLLLGGKRRR IYVTTTSSLL SDDWWQQFFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GVVVLEDECC QPPDPPPVVK VVVGQQQSLL LLLLGGKRRR LYVTTNSSLL SKKWWQQFFY GVVVLEEECC QPPDPPPVVK IIIGQQQSLL LLLLGGKRRR IYVTTSSSLL SIIWWQQFFY SVVAIGGTWW QSSDVVVPIQ LLLGQQQTLL LLLLGGKRRR LYVTTNSSLL SAAWWQQFFY SVVAVKGTWW QSSDVVVPIQ LLLGQQQSLL LLLLGGKRRR LYVTTNSSLL SAAWWQQFFY SVVAVGGSFF QFFDVVVPIK LLLGQQQSLL LLLLGGKRRR LYATTNSSLL SAAWWQQFFY SVVAVGGTFF QFFEVVVPIK LLLGQQQSLL LLLLGGKRRR LYATTNSSLL SAAWWSSFFY SVVYVTDEEE QYYSVVVPVK LLLGQQQSLL LLLLGGKRRR IYVTTNSSLL SRRWWQQFFY SVVVLEK--- PIIEAAALVK IIIGQQQSLL LLLLGGKRRR LYVTTTSSLL KKKWWQQFFY TVVVLEH--- EIIPAAALVK IIIGQQQSLL LLLLGGKRRR LYVSSTSSLL KKKWWQQFFY ---------- ---------- ---GAAQSVV VVVVGGKRRR LYVTTNSSFF STTWWQQFFY ARRVLNEKEE APPEPPPVLK LLLGQQQSLL LLLLGGRRRR LYVSSSSSLL SPPWWQQFFY LNNIVKEKEE RPPPAAARVK LLLGQQQSLL LLLLGGKRRR LYVSSSSSLL SPPWWQQFFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------SSWW WWWWGGKRRR VYFSSSSSLL ANNWW----- ---------- ---------- ------SSWW WWWWGGQRRR LYYTTSSSLL ANNWW----- YYYELKKGWM MVNNNANN-S SGGGLLEIIK FVF------A HHHHQRRLLS GGGDAADYP- YYY-LRRGWM MANNNVNN-E EGGGLLELLK FVF------A HHHHQRRLLW GGGDAADFP- YYYDVPPAAQ QVHHHAGG-D DGGGLLTLLD WVF------Y HHHHQRRLLE GGGDCCDFPS YYYDVPPGVE EVNNNVGG-N NGGGLLELLK FVF------Y HHHHQRRLLE GGGDCCDFPS YYYGRGGAAM MVNNNVGG-N NGGGLLTLLK WVF------Y HHHHQRRLLE GGGDCCDFPS YYYEIDDGWM MVDDDAGG-N NGGGIIEFFP FLW------H HHHHQRRLLQ GGGDCCDYP- YYYDIKKGWM MVDDDVNN-D DGGGMMQFFP FVF------Q HHHHQRRLLQ GGGDAADYP- YYYVIRRGWI IAEEEADD-G GGGGLLSLLP FTV------L HHHHQRRLLE GGGDSSDYPS YYYPLIIREG GSLLLQVVDN NGGGLLKLLP LVFPLGGGPA HHHHERRYYP GGGDCCDW-- YYYPLIIREG GSLLLQIIDN NGGGLLKLLP LVFPLGGGPA HHHHERRYYP GGGDCCDW-- YYYPLIIREG GSLLLQIIDK KGGGLLKLLP LVFPLGGGPA HHHHERRYYP GGGDCCDW-- YYYPLIIREG GSLLLQIIDK KGGGLLTLLP LVFPLGGGPA HHHHERRYYP GGGDCCDW-- YYYPLIIREG GSLLLQVVDK KGGGLLKLLP LVFPLGGGPA HHHHERRYYP GGGDCCDW-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYYPLIIREG GSLLLQVVDK KGGGLLKLLP LVFPLGGGPA HHHHERRYYP GGGDCCDW-- YYYPLIIREG GSLLLQIIDK KGGGLLKLLP LVFPLGGGPA HHHHERRYYP GGGDCCDW-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYYPMIIKEG GSLLLQIIDK KGGGLLKLLP LVFPGGGGPV HHHHERRYYP GGGDCCDW-- YYYPLLLKEG GALLLQIIDK KGGGLLKLLP LVFPDGGGPV HHHHERRYYP GGGDCCDW-- YYYPLVVEKG GSLLLQIIDK KGGGLLKIIP FVFPDGGGPA HHHHERRYYP GGGDCCDW-- YYYPLVVEQG GSLLLQIIDN NGGGLLKIIP FVFPDGGGPS HHHHERRYYP GGGDCCDW-- YYYPLMMDKG GSIIIQIIDK KGGGLLSIIP FVFPEGGGPA HHHHERRYYP GGGDCCDW-- YYYPIMMEKG GSIIIQIIDK KGGGLLTIIP FVFPDGGGPS HHHHERRYYP GGGDCCDW-- YYYQLVVKKG GSLLLQIIDK KGGGLLSIIP FVFPEGGGPS HHHHERRYYP GGGDCCDW-- YYYPHVVKSG GAVVVQVVNS SGGKMMEIIR LIFEGGGGPY HHHHERRYYP GGGDCCDW-- YYYPNVVRSG GALLLQIIDT TGGHMMVIIK LIFPGGGGPY HHHHERRYYP GGGDCCDW-- YYYPVVVKEG GSLLLQIIDK KGGGLLTVVK LVFPNGGGPC HHHHDRRFFP CCGDSSDL-- YYYPMVVAAG GGVVVQLLDN NGGGMMKLLE LVFPYGGGPG HHHHERR--- ---------- YYYPMVVSQG GGVVVLIIDN NGGGIISLLE LVFPYGGGPS HHHHERRYYP GGGDCCDWND ---------- ---------- ---------- ---------- ---------- ---------- -------KKG GKAAAQYYLW WDDGKKELLE AVFGLGGG-- HHHHIRRFFG SSSALLS--- -------KKG GKEEEQFFLW WDDGKKELLE AIFKLGGG-- HHHHQRRFFG AARALLGAGN ------- ------- SKK---- S------ S------ ------- ------- S------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- D------ ------- ------- NLLARVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMAKKAKQSE ATPPTAVPPG GAAAAGAAQQ SSPPTTTTTT ALTPGGSSSP VVVIIKKAYQ gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- --------MA gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QEEAAFSSSS AQQVLLASRE SGRKSPGVEE EIISSSSSAA KKKQQVVPPP AAAAVWAWLP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------GLG ---------- ---------- ---------- ---------- ---------- -----LLNSQ ---------- ---------- ---------- ---------- ---------- ---------- AGGSSTPPPP PNNNRRTPHN PAPAPPRPLL LTTRLLLLVV YYYRRIINNN PPPRLCPHAR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MK ---------- ---------- ---------- ---------- ---------- --------MK ---------- ---------A AVPKKKTTYP KKMMAKAPDD VCCYYYYTGR RAADDFIAAV ---------- ---------- -AKKKKTTYP RRDDARAPDD VAAYYYYVGA APPDDFLAAV ---------- ---------- -MSRRRTTHP EELLAQAAEE TLLSSSSPSR RPPDDALAAV ---------- ---------- -MTRRRTTHP KKLLAEAANN TLLSSSSPSK KPPDDALAAV ---------- ---------- -MTRRRTTYA KKLLAEGVKK TMMSSSSPSK KPPDDGLAAV ---------- ---------- -ATKKKSSYP RRLLAKAPTT VMMDDDDPKQ QPPDDAIAAV ---------- ---------- -VTRRRTTYP RRMMAKAAKK VRRNNNNPNK KPPDDAMCCV ---------- ---------- -ASRRRTTYP KKMMAQARRR VLLDDDDPER RPPDDALGGV ---------- --------MK KTK---GGPL EEAAM-GREE LCCYYYYRGA APPDDYLAAT ---------- ---------- ---------- ------GREE LCCYYYYRGA APPDDYLAAT PPHHALPPAR RRLPGG-AHQ QGK---GGPL EEAAM-GREE LCCYYYYGGA APPDDYLAAT ---------- ---------- ---------- ----M-GREE LCCYYYYRGA APPDDYLAAT ---------- --------MK KGN---GGSL EEAAM-GREE LCCYYYYRGA APPDDYLAAT AAEEFLVVAQ QQMPIIASTK KGN---GGSL EEAAM-GREE LCCYYYYRGA APPDDYLAAT ---------- --------MK KGN---GGSL EEAAM-G--- ---------A APPDDYLAAT ---------- --------MK KGN---GGSL EEAAM-GREE LCCYYYYRGA APPDDYLAAT GGPPTQFFLS SSQWQQEDTK KGD---GGPQ EEAAM-GREE LCCYYYYRGA APPDDYLAAT QQGGQNLLHT TTCLVVFTSK KGN---GGSL EEAAM-GREE LCCYYYYRGA APPDDYLAAT ---------- --------MK KGN---GGSL EEAAM-GREE LCCYYYYRGA APPDDYLAAT RRVVHMAAAA AAEAAAAANT TCHAAAGGAL EEAAMKGRKK VCCYYYYNGK KLLDDYLAAT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------K KGS---GGKL DDAAM-GREE LCCYYYYRGK KPPDDYLAAT -----MVVLD DDGVNNEKKV VGCKKKGGAI EESSM-GRSS VAAYYYYAGK KPPDDYLAAT -----MVVLQ QQAVSSEKVQ QGCKKKGGAL EEAAM-GRTT VAAYYYYAGK KPPDDYLAAT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MLVVVGGAL AAAAM-GSKK VAAYYYYTGK KPPDDYLAAT ---------- ---AAAAANA ACGAAAGGAL EEAAMKGRKK VCCYYYYNGK KPPDDYLGGT ---------- ---MSSPNCK KHG---GGAA DDAAI-GREE VAA-----AG GPPDDAIFFT ---------- ---MPP--CK KHG---GGAA DDAAI-GREE VAA-----AG GPPDDAIFFT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------S SSKKKKGGAL DDAAVNGVKK VCCQQQQPDH HGGDDYLAAT ---------- ---------- ---------- ----MSGRKK TTTQQQQPDH HGGDDYLSST ---------- ---------- ------GGI- DDIILSLDFF SWWHHHHGRD DIITTDRKKN KKFF------ --LAGG-ALG GPFAAAEECP YYMMPITQEE VTTGGGGVME EQQDDKLVVT KKVVPMAALR RRLSGGLALA APAVVVEECP YYMMKITQDD VTTGGGGAVE EQQDDKLVVT VDVNNNKKEE SSSKKIVVHK VELIHWWNNN AAACSSSSSS ANN-KKNEEE RRRFVGRSSR VDVDDDKKPP GGGKKVIIYK LDLIHWWNNN AAACSSSSSS ANN-KKFEEE RRRYVARSSR IDVKKKGGSS GGGKKIVVHT VTMTHWWNNN AAACSSSSSS SLLGHHFEEE RRRFIGRSSR IDVKKKGGPP GGGQQIVVHT VTMKHWWNNN AAACSSSSSS ALLGHHFEEE RRRYIGRSSR VDVDDDTTEE GGGQQIVVHQ LIMKHWWNNN AAACSSSSSS ALLGHHFEEE RRRYIGRSSR VDVDDDAAPP AAASSIVVGQ VAMAHWWNNN AAACSSSSSS CNNPHHHEEE RRRYVGRSSR VDVDDDQQSS GGGQQVVVGV TDMTHWWNNN AAACSSSSSS MNNPHHHEEE RRRYVDRSSH LDLDDDDDGG AAAQQIVVGR VEMAHWWNNN AAACSSSAAA AYYPHHHEEE RRRYVGRSSR VDVDDDKKPP SSSQQVIIHR LPMLHWWNNN TTTCSSSSSS C--GDDTSSS RRNKLGMSSR VDVDDDKKPP SSSQQVIIHR LPMLHWWNNN TTTCSSSSSS C--GDDTSSS RRDKLSISSR VDIDDDKKPP CCCQQVIIHR LPMLHWWNNN AAACSSSSSS C--GDDTSSS RRTKLCMSSR VDVDDDKKPP CCCQQVIIHR LPMLHWWNNN TTTCSSSSSS C--GDDTAAA RRTKLAISSR VDVDDDKKPP CCCQQVIIHR LPMLHWWNNN TTTCSSSSSS C--GDDTSSS RRTKLSISSR VDVDDDKKPP CCCQQVIIE- ---------- ---------- ---------- ---------- VDVDDDKKPP CCCQQVIIHR LPMLHWWNNN TTTCSSSSSS C--GDDTSSS RRTKLSISSR VDVDDDKKPP CCCQQVIIHR LPMLHWWNNN TTTCSSSSSS C--GDDTSSS RRTKLSISSR VDVDDDKKPP SSSQQVIIHR LPMLHWWNNN TTTCSSSSSS C--GDDTSSS RRNKLSISSR VDVDDDKKPP CCCQQVIIHR LPMLHWWNNN TTTCSSSSSS C--GDDTSSS RRTKLS---- VDVDDDKKPP CCCQQVIIHR LPMLHWWNNN TTTCSSSSSS C--GDDTSSS RRTKLSISSR VDLDDDSSPP SSSQQVIIHR LPVIHWWNNN SSSCSSSSSS C--GDDSKKK RRRFLSLSGR ---------- ---------- --MTHWWNNN TTTCSSSSSS C--GDDSVVV RRNKLCISSR VDVDDDKKPP SSSQQVIIHR LPMVHWWNNN TTTCSSSSSS C--GDDSVVV RRNKLCISSR VDVDDDSSPP SSSKKVIIHR LPVVHWWNNN SSSCSSSSSS C--GDDSEEE RRRFASVSGR VDLDDDNNPP SSSKKVIIHR LPVVHWWNNN SSSCSSSSSS C--GDDSQQQ RRRFVGVSGR ---------- ---------- --MVHWWNNN SSSCSSSSSS C--GDDSDDD RRRYLSISGR VDVDDDSSPP SSSSSVIIHR LPMVHWWNNN SSSCSSSSSS C--GDDSDDD RRRYLSISGR VDVDDDNNPP SSSQQVIIHR LPVVHWWNNN AAACSSSSSS C--GDDSSSS RRRFLSLSGR VDVNNNEEDD CCCQQVIISR VDVIHWWNNN AAACSSSSSS C--DKKTKKK RRSHVCNSDR VNVNNNEEEE CCCQQIIISR VDVIHWWNNN AAACSSSSSS C--DKKTKKK RRSHVCNSDR ---------- ---------- ---------- ---------- ---------- ----PKSSGV VDVDDDAAPP CCCQQVIIHR TYTKHWWNNN TTTCSSSSSS C--GKKVTTT RRDRLCNSDR VDVDDDEEPP CCCQQIVVHR TFTKHWWNNN AAACSSSSSS CEESKKVKKK RRDRLSNSDF PRMVVVQQFF GGGSSVLLKD GPVLLPPTTT PPPRIIILLL K--GKKVGGG GGPQQSDGKR IDLRRRGGAA GGGQQVIINS VSV-HFFSSS AAA------- -------DDD RRRFTGDTNR VDANNNKKPP GGGKKVVVNT LSV-HFFTTT DDD------- -------DDD RRRYAGDTSK RRIYIIIIDD TTKPNPEEKK IIIIKVEEEE EKKVVVSSSS SSYSSSHVVC PPPDAAGNE- RRIYIVVVDD TTKPDKRRAA AAAAKIEEVV VVGRRRTTTT TTYTTTHVVC PPPDAAGGP- RRIYVIIIDD TTKPHPQQRR HHHHKIEDEE ELAKKKTTTT TTYSSSHVVC PPPETTGGAK RRIYIIIIDD TTKPDPKKKK HHHHKIEEEE EFKKKKTTTT TTYSSSHIIC PPPDTTGGGK RRIYIVVVDD VVK-EPKKKK HHHHKIEEEE EFAKKKTTTT TTYSSSHIIC PPPETTGGGE RRIYILLLDD TTKPDPKKFF AAAAKVEETT TAERRRTTTT TTYSSSHVVC PPPGAAGNA- HHITILLLDD TTKPDPQQKK VVVVKVDNEE EAERRRTTTT TTYAAAHVVC PPPDAAGSP- RRIHIVVVDD TTKPDPEERR VVVVKVEEEE EHRRRRTTTT TTYSSSHIIC PPPDAAGSP- RRIYVVVVDD VVGSEPAAKK HHHHKVESEE EQAKKKCCCC CCVSSSHSSC AAASNNLGD- RRIYVVVVDD VVGSEPAAKK HHHHKVENEE EHAKKKCCCC CCLGGGHSSC AAASSSLGD- RRIYVVVVDD VVGSDPAAKK HHHHKVEEDD DHAKKKCCCC CCLGGGHSSC AAASSSLGD- RRIYVVVVDD VVGTEPAAKK HHHHKVEKDD DHTKKKCCCC CCLGGGHSSC PPPSSSLGD- RRIYVVVVDD VVGSEPAAKK HHHHKVEEDD DHAKKKCCCC CCLAAAHSSC AAASSSLGD- ---------- ---------- -------KDD DHAKKKCCCC CCLAAAHSSC AAASSSLGD- RRIYVVVVDD VVGSEPAAKK HHHHKVEKDD DHAKKKCCCC CCLAAAHSSC AAASSSLGD- RRIYVVVVDD VVGSEPAAKK HHHHKVEKDD DHAKKKCCCC CCLAAAHSSC AAASSSLGD- RRIYVVVVDD VVGTEPAAKK HHHHKVEKDD DHEKKKCCCC CCLGGGHSSC PPPTSSLGD- ---------- ---------- ---------- ---------- ---------- ---------- RRIYVVVVDD VVGSEPAAKK HHHHKVEKDD DHAKKKCCCC CCLAAAHSSC AAASSSLGD- RRVYVVVVDD TTATDPTTSS HHHHKVEEDD DAENNNIIII IILGGGHSSC AAASSSLGD- RRIYVVVVDD VVGTDPAARR HHHHKTEYEE EFWKKKCCCC CCLAAAHSSC GGGCSSIGD- RRIYVVVVDD VVGSDPAARR HHHHKTEYEE EFWKKKCCCC CCLAAAHSSC GGGCSSLGD- RRIYVIIIDD TTKTNPSSSS HHHHKVDADD DIQKKKTTTT TTLAAAHSSC AAASSSLGD- RRVYVIIIDD TTKTNPAASS HHHHKVEEDD DSTKKKTTTT TTLAAAHSSC AAASSSIGD- RRIYAIIIDD TTKENPAASS YYYYKYDKEE EAEKKKTTTT TTLAAAHAAC AAASSSLGD- RRIYAIIIDD TTKENPAASS YYYYKYDKEE EADKKKTTTT TTLAAAHAAC TTT-SSLGD- RRVYVVVVDD TTLKDPAAAA HHHHKVEEDD DAEKKKTTTT TTLGGGHSSC AAASSSLGD- RRIYIIIINN VVENE-KKYY EEEEHTESKK KHSLLLNNNN NNLSSSHSSC AAADSSLGE- RRIYVIIINN VVENE-EEYY QQQQHTESKK KHALLLNNNN NNLSSSHSSC AAADSSLGE- VVEGKVVVFF VVGG------ ---------- ---------- ---------- ---------- RRIFVIIIDD TTGTDPAAKK AAAAKVE-DD DLKGGGAAAA AACTTTHTTC PPPNSSMGD- FFIYILLLDD VVVTDPKKEE VVVVKTD-DD DLKSSSHHHH HHVTTTHTTC AAANSSMGD- RRLYVTTTTT SSLYSADDQQ YYYYP---DD DIKFFFLLLL LLLAAAHAAY PPPNDDVNE- RRIFIFFFDD VVHSDPNNKK HHHHKTD-FF FKDSSSGGGG GGVVVVHFFA PPPGGGSND- KKIFVFFFDD VVHSDPRRVV SSSSKTT-FF FEKSSSGGGG GGVVVVHLLA PPPGGGSNN- -EEG-EEGPP ILMLSFFEPL GKIIRRRRGG DQYYY----- ------LADW WNLLLLPPPE -DDGREEGPP IFLLTFFEPI GRVVRRRRGG PQYYY----- ------FADW WNLLLLPPPG KDDGTDDGAA IFIMTFFDVL GRIIRRRRGG PQDDD----- ------KHDW WNLLLLPPPD KDDGTNNGPP VFIMTFFEVL GRIIRRRRGG PQTTT----- ------LHDW WNLLLLPPPD EDDGTDDGPP IFILTFFEIL GRMMRRRRGG EQTTT----- ------KHDW WNLLLLPPPD -EEG-KKGPP IAMLSFFEPL GRVVRRRRGG PQYYY----- ------FADW WHLLLLGGGD -EEG-EEGPP IFILNLLEVL GRIIRRRRGG DQYYY----- ------LHDW WHLLLLGGGD -EEG-DDGPP VFVMSFFDPL GRVVRRRRGG PQQQQ----- ------LADW WHLLLLGGGD -LLQGNNGKK FVLLTFFEVK GTKKGGGGGG ASPPP----- ------MGDW WQPPPPRRRN -PPQGNNGKK FVLLTFFEVK GTKKGGGGGG EAPPP----- ------MGDW WQPPPPRRRN -SSKGNNGKK FVLLTFFEVK GTQQGGGGGG AAPPP----- ------MGDW WQPPPPRRRN -PPEGNNGKK FVLLTFFEVK GTQQGGGGGG AAPPP----- ------LGDW WQPPPPRRRN -VVKGNNGKK FVLLTFFEVK GTRRGGGGGG AAPPP----- ------SGDW WQPPPPRRRN -VVKGNNGKK FVLLTFFEVK GTRRGGGGGG AAPPP----- ------LGDW WQPPPPRRRN -VVKGNNGKK FVLLTFFEVK GTRRGGGGGG AAPPP----- ------LGDW WQPPPPRRRN -VVKGNNGKK FVLLTFFEVK GTRRGGGGGG AAPPP----- ------LGDW WQPPPPRRRN -PPKGNNGKK FVLLTFFEVK GTRRGGGGGG SAPPP----- ------MGDW WQPPPPRRRN ---------- ---------- ---------- ---------- ---------- ---------- -VVKGNNGKK SLVLRLLECS G--------- ---------- ---------- ---------- -KKEGNNAAA GFLLEFFNVK GRNNLLLLFF PISSS----- ------KETL LENNNNAAAG -PPYGNNGKK FVLLTFFEVK GNAAGGGGEE AAPPP----- ------FGDW WQPPPPRRRN -PPCGNNGKK FVLLTFFEVK GNVVGGGGEE SAQQQ----- ------FGDW WQPPPPRRRN -KKDGNNAEE GFLLDFFNVK GRKKGGGGHH SPLLL----- ------FGDW WQPPPPRRRN -KKDGNNAEE GFLLEFFNVK GRKKGGGGHH SPLLL----- ------FGDW WQPPPPRRRN -EEEGNNAKK GFLLDFFNIK NRKKGGGGHH SPLLL----- ------FGDW WQPPPPRRRK -EEEGNNAKK GLLLDFFNIK NRKKDDDDII SPLLL----- ------YGHW WQPPPPRRRK -KKEGNNAAA GFLLEFFNVK GRKKGGGGHH SPLLL----- ------FGDW WQPPPPRRRK -AANGTTPSS FLLLTFFEPK GTAAEEEEKK TVPPP----- ------FNDW WQPPPPRRRN -AADGSSPSS FLLLTFFEPK GTAAGGGGKK VVPPP----- ------FNDW WQPPPPRRRN ---------- ---------- ---------- ---------- ---------- ---------- -AAEGNNAKK DFVENFFELV GTRRDDDDRR KALLL----- ------CGDW WQPPPPHHHN -AAEGYYAKK DFILDFFNCI GTKKDDDDKK KALLL----- ------CGDW WQPPPPYYYD -SSLSVVPVV GIQTENNGLS AKAAQQQQFF EEIII----- ------LQSH HNGGGG---E -DDDHGGGRR LVEYGEEYVA TYPPAAAADD DMQQQVVVVG DAAADGYGDR RLIIIIRRRN -KKDHGGGRR LVEYGEEYVA THPPDDDDGG DLRRRTTTTG -KKADGYDDR RLPPPPRRRN EEEVVLLVVE WWWAAPP--- TDGG-KEEHL KKKKYGGNRR HWWLLRRRRI HHSSTGEERA GGGVVMMIIE WWWTTPP--- CEGG-SEECL KKKKYGGNKK HWWLLAHHHL YYAADGQERV DDDYYMMVVE WWWAAPP--- QNGG-VEEDL LLLLYGGHRR HWWLLRNNNV QQTTDGAQQA DDDYYMMVVE WWWAAPP--- QNGG-VEEDL LLLLYGGHRR HWWLLRNNNV QQTTDGANQA DDDYYMMVVE WWWGGPP--- QNGG-VEEDL LLLLYGGHKK HWWLLRNNNV QQTTDGANQA DDDTTLLVVE WWWGGPP--- MDGG-VDDIL LLLLYGGRRR HWWLLTHHHL QQEEDGDEQV DDDTTLLLLE WWWGGPP--- MSGG-LDDEL LLLLYGGHRR HWWLLYHHHL QQTTDGAEQA DDDTTMMVVE WWWGGPP--- MGGG-DQQIL LLLLYGGRRR HWWLLRHHHL QQAADGEEQV NNNVVMMVVE WWWAAPP--- VDGGFPHHVE AAAAYGGSRR FWWWWQIIII QQTTQT--GI NNNIIMMVVE WWWAAPP--- VDGGFPHHVE AAAAYGGSHH HWWWWQIIII QQTTQK--GI NNNVVMMIIE WWWAAPP--- VDGGFPDDVE AAAAYGGSHH HWWWWQIIII QQTTTQ--GI NNNVVMMIIE WWWAAPP--- VDGGFPDDVK AAAAYGGSHH YWWWWQIIIV QQTTPQ--GI NNNVVMMIIE WWWAAPP--- VDGGFPDDVE AAAAYGGSHH YWWWWQIIIV QQTTSK--GI NNNVVMMIIE WWWAAPP--- VDGGFPDDVE AAAAYGGSHH YWWWWQIIIV QQTTSK--GI NNNVVMMIIE WWWAAPP--- VDGGFPDDVE AAAAYGGSHH YWWWWQIIIV QQTTSK--GI NNNVVMMIIE WWWAAPP--- VDGGFPDDVE AAAAYGGSHH YWWWWQIIIV QQTTSK--GI NNNVVMMIIE WWWAAPP--- VNGGFPDDVE AAAAYGGKHH HWWWWQIIIV QQTTLP--GI ---------- ---------- ---------- ---------- ---------- ---------- ---------I SSSAASS--- LTGGSDPPAS AAAAVAAGII ---------- ---------- GGGLLFFWWI QQQCCSS--- FTGGALCCLT AAAAVHHVII CDDYYIIIID EESSPQ--QG NNNVVMMIIE WWWGGPP--- ALGGFMEEVQ AAAAYGGHSS NWWWWTRRRI QQTTDGE-GI NNNVVMMIIE WWWGGPP--- ALGGFMDDVQ AAAAYGGHSS NWWWWTLLLV QQTTDGK-GI NNNTTMMIIS WWWGGPP--- AKGGFLHHVA DDDDYGGRHH TIILLALLLR QQTTDGN-GL NNNTTMMIIS WWWGGPP--- AQGGFLHHVA DDDDYGGRHH HYYWWPIIIK QQTTDGD-GL KKKTTMMIIS WWWGGPP--- AKGGFLHHVA DDDDYGGSHH HYYWWPMMMK QQLLDGE-GL KKKTTMMIIS WWWGGPP--- AKGGFLHHVA DDDDYGGSHH HYYWWPIIIK QQLLDGP-GL KKKTTMMIIS WWWGGPP--- ATGGFLHHVQ DDDDYGGRHH HYYWWPLLLK QQTTDGS-GL NNNVVMMIIE WWWGGPP--- HKGGFPHHVG EEEEYGGNSS HFFWWDYYYL QQTTDPQPGL NNNIIMMIIE WWWGGPP--- HKGGFPHHVP EEEEYGGNSS HFFWWDHHHL QQTTDPMPGL ---------L RRRGGPP--- TRDDELCCQP EEEEVIIKCC RYY------- ---------- NNNVVMMVVE WWWGGPP--- LRGGYPDDCD DDDDYGGCRR NYYWWQLLLF QQTTDGD-GT DDDVVMMVVE WWWGGPP--- KRGGWNDDLE DDDDYGGCRR NYYWWSLLLY QQTTDGS-GT EEEKKSSEER PPPDDPP--- MESSSSLLKK TTTTKPPQHH AVV------- ---------- NNNVVMMLLS FFFTTWWNYY MFGGQLDDAE AAAAFGGNTT VWWLLHPPPK KKVVNPGA-- NNNLLLLVVS FFFTTWWNYY MFGGKLDDPE AAAAFGGNTT VWWLLHPPPK KKVVDPGA-- L-----ELLL LRPLLHPPPT LLMGFMMVVS SKLSSSSSII WYYYGGGKAA EEVIIIEEPA L-----EVVV VRPLLHPPPT LLMGFVVLLN NKLSSSSSII WYYYGGGKAA EEVIIIDDEA L-----EVVV VRPAAHPPPV EEYGFVVVVD DTLEEEGGII WRRRGGGKVV KKTAAATTPA L-----EVVV VRPAAHPPPV EEYGFVVVVD DTLEEEAAII WRRRGGGKAA EETAAATTPP L-----EIII IRPAAHPPPS DDYGFVVVVD DTLQQQGGII WQQQGGGTAA KKTIIITTDP F-----ELLL LRPAAHPPPT AAYGFCCIIS SKLSSSSSII WRRRDDDKVV RRVIIIEEPA L-----ELLL LRPAAHPPPT AAYGFCCVVS SKLSSSAAII WRRRGGGSLL KKVIIIDDPA L-----ELLL LRPAAHPPPA TTYGFVVVVS SELSSSAAVV WRRRGGGSII RRVIIIEEPA P-----EIII IRFLLHPPPS TTQGFCCLLS SNQRRRFFKK E--------- ---TTTWWVE P-----EIII IRFLLHPPPD TTQGFCCLLS SNQRRRFFKK G--------- ---TTTWWVE P-----EIII IRFLLHPPPD AAQGFCCLLS STQRRRFFKK G--------- ---TTTWWVE P-----EIII IRFLLHPPPD AAQGFCCLLS STQRRRFFKK D--------- ---TTTWWAQ P-----EIII IRFLLHPPPD AAQGFCCLLS STQRRRFFKK G--------- ---TTTWWVE P-----EIII IRFLLHPPPD AAQGFCCLLS STQRRRFFKK G--------- ---TTTWWVE P-----EIII IRFLLHPPPD AAQGFCCLLS STQRRRFFKK G--------- ---TTTWWVE P-----EIII IRFLLHPPPD AAQGFCCLLS STQRRRFFKK G--------- ---TTTWWVE P-----EIII IRFLLHPPPA SSQGFCCLLS STQRRRFFKK G--------- ---TTTWWVE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ANNPIICLLL LRSIIHKKKN NNQDYVVVVS SSRGGGGGDD A--------- ---AAAVVLK P-----EIII IRFLLHPPPD AAQGLCCLLS STFRRRFFKK D--------- ---KKKWWAE P-----EIII IRFLLHPPPD DDQGLCCLLS SSFRRRFFKK D--------- ---KKKWWAE P-----EIII IRFLLHPPPA DDTGFSSLLS SNIRRRFFKK D--------- ---SSSWWHE P-----EIII IRFLLHPPPA DDTGFSSLLT TNIRRRFFKK D--------- ---SSSWWHE P-----EIII IRFLLHPPPS DDTGYSSLLS SNIRRRFFKK D--------- ---TTTWWYE P-----EIII IRFLLHPPPS DDTGFSSLLS SNIRRRFFKK D--------- ---TTTWWHE P-----EVVV VRFLLHPPPS DDTGYCCLLT TNVRRRFFKK D--------- ---SSSWWHE P-----EVVV VRFLLHPPPT EEHAFCCLLG GGFRRRIIPP ESSS------ ---TTTHHAT P-----EVVV VRFLLHPPPT EEHAFCCLLG GAFRRRIIPP KPPP------ ---VVVQQAS ---------- ---------- ---------- ---------- ---------- ---------- P-----EIII IRFLLHPPPR NNQGYCCFFX XXXXXXXX-- ---------- ---------- P-----EIII IRFLLHPPPK AAEGFCCLLN NKFHHHFFKK DDDD------ --FEEEAAKV ---------- ---------- ---------- ---------- ---------- ---------- ------EIII IRFPPWSSSN NNYAFTTLLT TQWLLLIIEE A--------- ---------- ------EIII IRCAAWEEEA NNYCFTTLLT TQWLLLIIEE E--------- ---------- PPPLLLEEEG --NPEIKFKV PPPPVDDDII SLDDDDDFFY LSLWIIEYYD IIISPPFFFF PPPFFFEEEG --PPPVKFKV PPPPVDDDII SLDDDDDFFY VSLWLLEYYD IIITPPHHHH PPPAAATTTA DDEPPLQFGV PPPPVDDDIL SLDDDDDFFY VSCWTTEYYD VVVSPPHHHH PPPAAAPPPK EEKPPLQFGV PPPPVDDDIL SMDDDDDFFY VSCWTTEYYD VVVSPPRRRR PPPAAADDDA DDDPDLKFGC PPPPVDDDIL SLDDDDDYYY VACWLLEYYD VVVSPPMMMM AAAAAADDDP DDQPPVKFKV PPPPVDDDIL SMDDDDDFFY VSCWTTDYYD VVVSPPFFFF PPPAAASSSE DDQPPIKFKV PPPPVDDDIL SVDDDDDFFY VSCWTTEYYD VVVSPPFFFF PPPAAAEEEP DDQPPLKFGV PPPPVDDDIL SLDDDDDFFY VSCWTTEYYD VVVSPPFFFF VVVIIIQQQV PPSKVKWLPM PPPPIDDDIL SLDDDDDFFY FSNWHHDYYD IIISPPQQQQ VVVIIIQQQV PPSKVKWLPM PPPPIDDDIL SLDDDDDFFY FSNWHHDYYD IIISPPKKKK VVVIIIQQQV PPPKVKWLPM PPPPIDDDIL SLDDDDDFFY FSNWHHDYYD IIISPPQQQQ VVVIIIQQQV PPPKVKWLPM PPPPIDDDIL SLDDDDDFFY FSNWHHDYYD VVVSPPQQQQ VVVIIIQQQV PPPKVKWLPM PPPPIDDDIL SLDDDDDFFY FSNWHHDYYD IIISPPQQQQ VVVIIIQQQV PPPKVKWLPM PPPPIDDDIL SLDDDDDFFY FSNWHHDYYD IIISPPQQQQ VVVIIIQQQV PPPKVKWLPM PPPPI----- ---------- ---------- ---------- VVVIIIQQQV PPPKVKWLPM PPPPIDDDIL SLDDDDDFFY FSNWHHDYYD IIISPPQQQQ VVVIIIEEEV PPPKVKWLPM PPPPIDDDIL SLDDDDDFFY FNNWHHDYYD IIISPPKKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKKLLLDDDL YYYVVAFVVL SSSSFPPPAI FFSDDDDLLI FLS------- ---------- VVVIIIKKKV PPSKVEWLPM PPPPIDDDII SLDDDDDFFY FSNWHHDYYD IIITPPRRRR VVVIIIQQQV PPSKVEWMPM PPPPIDDDII SLDDDDDFFY FSNWHHDYYD IIITTTRRRR AAAIIIPPPV KKPKVQWLPM PPPPIDDDFI SLDDDDDFFY FVNWHHDYYN IIIELLKKKK VVVIIISSSV EEPKVQWLPM PPPPIDDDFI SLDDDDDFFY FVNWHHDYYN IIIEVVKKKK VVVIIISSSV KKPKVEWLPM PPPPIDDDFI SLDDDDDFFY FVNWHHDYYN IIIEPPKKKK VVVIIISSSV KKPKVEWLPM PPPPIDDDFI SLDDDDDFFY FVNWHHDYYN IIIEPPKKKK AAAIIISSSI KKPKVRWLPM PPPPIDDDFI SLDDDDDYYY LVNWHHDYYN IIIEPPAAAA VVVAAAFFFI PPSKVSWLPM PPPPIDDDII SMDDDDDFFY VSCWHHDYYD IIISPPLLLL VVVAAATTTI PPSKVEWLPM PPPPIDDDII SMDDDDDFFY VSCWHHDYYD IIISPPKKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---QGEGIEM GGGGMDDDII SLDDDDDYYY FSNWHHDYYD IIISRRAAAA DDDIIIPPPG KKLDTGGAEM GGGGIDDDII SLDDDDDFFY VNCWHHDYYD IIITPPEEEE ---------- ---------- ---------- ---------- ---------- ---------- ------EEEW QQAAVAINPD IIIIPDDDII AADDDDDTTW INSFDDKFFD IIISPPHHHH ------EEEW QQAAVAIEPK VVVVPDDDII SNDDDDDRRW VNTFDDKFFD IIISPPHHHH KLTTKKVGFR ADHH------ -----AGGGH HKLLTAPQMM LLERRRRRVY YYSLLYYSWN QLAARRVGYR EPHH------ -----SGGGA AEAATAPQMM IISRRRRRVY YYSLLYYSWN NLAASSVGAR APHH------ -----NGGGR RTFFAGPQMM VVERRRRRVY YYSLLYYSWD KLAASSVGAR TPHH------ -----NGGGK KAFFAGPQMM VVERRRRRVY YYSLLYYSWD NLTTKKVGVK TPHH------ -----NGGGK KTFFGGPQMM VVERRKRRVY YYSLLYYSWE ELTTKKVGVR ATHH------ ----AKNNNG GALLNGPQMM VVERRRRRVY YYSLLYYGVP NLTTKKVGVR AGHH------ ----ATSSSA AELLNGPQMM VVERRRRRVY YYSLLYYRWE NHTTSSVGVK AAHH------ -----ASSSG GPLLNGPQMM VVERRRRRVY YYSLLYYAWE KLTTQQIGIR GGSS-DDQTQ PPPLVKGGGK KRIIPGPQMM IIQLLKRRLY YYSLLYYSWK KLTTQQIGIK GGSS-DDQTQ PPPLVKGGGK KRVVPGPQMM IIQLLKRRLY YYSLLYYSWK RLTTQQLGIK GGPP-DDQKQ PPPLVKGGGK KKVVPGPQMM IIQLLKRRLY YYSLLYYSWK RLTTQQLGIK DGPP-DDQDQ PPPLVKGGGK KQVVAGPQMM IIQLLKRRLY YYSLLYYSWK RLTTQQLGIK GGPP-DDQKQ PPPLVKGGGK KRVVAGPQMM IIQLLKRRLY YYSLLYYSWK RL-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RLTTQQLGIK GGPP-DDEKQ PPPLVKGGGK KRVVAGPQMM IIQLLKRRLY YYSLLYYSWK RLVVQQIGIK GGPP-DDQKQ PPPLVKGGGK KRVVPGPQMM IIQLLKRRIY YYSLLYYSWK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NLVVQQIGIR GGPP-DDKEQ PPPVVKGGGK KKVVPGPQMM IIQLLKRRLY YYSLLYYSWK NLVVQQIGIR GGPP-DDKEQ PPPVVKGGGK KIIIPGPQMM IIQLLKRRIY YYSLLYYSWK NLTTQQLGIK GSPP-EEDTQ SVVPIQGGGQ QKLLRGPQMM IIQLLKRRLY YYSLLFFSWK NLTTQQVGIK GSPP-DDDTQ SVVPIQGGGK KKLLRGPQMM IIQLLKRRLY YYSLLFFSWK NLTTQQIGLK GSPP-EEDSQ FVVPIKGGGK KSLLRGPQMM IIQLLKRRLY YYSLLFFSWR NLTTQQIGLK GSPP-EEDTQ FVVPIKGGGK KSLLRGPQMM IIQLLKRRLY YYSLLFFSWV KLAAQQVGLK GSEE-EEDEQ YVVPVKGGGH HRLLRGPQMM IIQLLKRRIY YYSLLFFSWE KLNNQQVGVT ESNN-GGE-P IAALVKGGGR RKIIEGPQMM LLQLLKRRLY YYSLLYYKWD NLNNQQVGIS ETTT-EED-E IAALVKGGGR RQIIEGPQMM LLQLLKRRLY YYSLLYYKWD ---------- ---------- ---------- -----GPAKK IIQVVKRRLY YYSFFYYSWK NLTTQQVGIR DAPP-DDPKA PPPVLKGGGR RRLLLGPQMM LLQLLRRRLY YYSLLFFSWK NLTTQQLGIS DLPPEDDKKR PAARVKGGGR RRLLEGPQMM LLQLLKRRLY YYSLLYYSWK ---------- ---------- ---------- ---------- ---------- ---------- KQIIEEKRV- ---------- ---------- --------MM VVSWWKRRVY YYSLLLLAW- HQVVEEKAV- ---------- ---------- --------MM VVSWWQRRLY YYSLLLLAW- NYEEGGLLKG GMVKNNN--- PSGIDKKKKE FFFFFF---A ARQVVRGGDS DDSSYCCCY- NY--GGLLRG GMAKNNN--- PEGLEKKKKE FFFFFF---A ARQVVRGGDT DDSSFCCCY- DYDDGGVVPA AQVLHGG--- PDGLADDDDD YYYYWF---Y YRQIIRGGDT DDSSFCCCYS DYDDGGVVPG GEVMNGG--- GNGLDKKKKD YYYYFF---Y YRQIIRGGDT DDSSFCCCYS EYGGDDRRGA AMVMNGG--- ENGLDKKKKD FFFFWF---Y YRQIIRGGDT DDSSFCCCYS PYEEGGIIDG GMVKDGG--- PNGFDPPPPK FFFFFW---H HRQVVRGGDS DDSSYCCCY- EYDDGGIIKG GMVKDNN--- PDGFDPPPPN FFFFFF---Q QRQIIRGGDS DDSSYCCCF- EYVVGGIIRG GIAKEDD--- PGGLDPPPPG FFFFFV---L LRQIIRGGDS DDSSYCCCYS KYPPDDLLIR RGSVLVVDDD VNGLNPPPPN FFFFLFPPPA ALELLRGGDS DDIIWIII-- KYPPNNLLIR RGSVLIIDDD ANGLNPPPPN FFFFLFPPPA ALELLRGGDS DDIIWIII-- KYPPDDLLIR RGSVLIIDDD VKGLNPPPPN FFFFLFPPPA ALELLRGGDS DDIIWLLL-- KYPPDDLLIR RGSVLIIDDD VKGLNPPPPN FFFFLFPPPA ALELLRGGDS DDIIWLLL-- KYPPDDLLIR RGSVLVVDDD VKGLNPPPPN FFFFLFPPPA ALELLRGGDS DDIIWIII-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KYPPDDLLIR RGSVLVVDDD VKGLNPPPPN FFFFLFPPPA ALELLRGGDS DDIIWIII-- KYPPDDLLIR RGSVLIIDDD VKGLNPPPPN FFFFLFPPPA ALEIIRGGDS DDIIWLLL-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KYPPDDMMIK KGSVLIIDDD EKGLNPPPPN FFFFLFPPPV VLELLRGGDS DDIIWVVV-- KYPPDDLLLK KGAVLIIDDD KKGLNPPPPN FFFFLFPPPV VLEIIRGGDS DDIIWIII-- KYPPGGLLVE EGSHLIIDDD EKGINPPPPN FFFFFFPPPA ALEMMRGGDS DDIIWIII-- KYPPKKLLVE EGSHLIIDDD ENGINPPPPN FFFFFFPPPS SLEMMRGGDS DDIIWIII-- RYPPEELLMD DGSHIIIDDD EKGINPPPPN FFFFFFPPPA ALEMMRGGDS DDIIWIII-- VYPPEEIIME EGSHIIIDDD EKGINPPPPD FFFFFFPPPS SLEMMRGGDS DDIIWIII-- EYQQDDLLVK KGSHLIIDDD EKGINPPPPN FFFFFFPPPS SLEMMRGGDS DDIIWIII-- DYPPEEHHVK KGATVVVNND ESKINRRRRD FFFFLFEEPY YLEMMRGGDS DDIIWIII-- DYPPEENNVR RGATLIIDDD ITHINKKKKN FFFFLFPPPY YLEMMRGGDS DDIIWIII-- KYPPNNVVVK KGSVLIIDDD EKGVNKKKKN FFFFLFPPPC CLDIIRCCDS DDIILAAA-- KYPPEEMMVA AGGTVLLDDD ENGLNEEEEN FFFFLFPPPG GLEMMR---- ---------- KYPPKKMMVS SGGHVIIDDD VNGLNEEEED FFFFLFPPPS SLEMMRGGDS DDIIWLLLAD ---------- ---------- ---------- ---------- ---------- ---------- ---------K KGKDAYYLLA NWGLVEEEED FFFFAFGG-- -RIMMRSSAS SS-------- ---------K KGKDEFFLLL YWGLKEEEEQ FFFFAFKK-- -RQMMRAAAA GGPPAGGGDN ------- ------- VVVR--- VVV---- VVV---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AAA---- ------- ------- RRRVARR 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNNNSSSAKK PSAPRTTVGL LTTTALAGAQ QSSSLRRRTL LSLLLTPGPP VRIIISSIQV gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -----LPLNN gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVSSSSRRRE SGKTRRSSSV VVVVVPPPLV VEIISSAVAA AQVPSQQAAV QWWWLLPPGH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------AARE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----LLGGEP ---------- ---------- ---------- ---------- ---------- -LLLSSQQCG ---------- ---------- ---------- ---------- ---------- ---------- NNPPTTHHHN PAASPPPPPH HHHHHPPPVP PLTTRLVRPP PRINVPPPPL PCCCAARRSV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMKKRF ---------- ---------- ---------- ---------- ---------- ----MMKKFV ---------- --MMAVVVFK KDPFPPSPPM MAMKAALLYY VCCLLYTTTG GGINRDFIVV ---------- -----AAALK KDPFPPTPPD DAMRAAIIYY VAALLYVTTG GGVNADFLVV ---------- -----MMMMR RDPFAASPPL LAMQAAFFYY TLLLLSPFFS SS--RDALVV ---------- -----MMMMR RDPFAASPPL LAMEAAFFYY TLLLLSPFFS SS--KDALVV ---------- -----MMMLR RDPFPPSAAL LAMEGGLLFF TMMLLSPAAS SS--KDGLVV ---------- -----AAAWK KDPFPPSPPL LAAKAAIIYY VMMFFDPRRK KK--QDAIVV ---------- -----VVVWR RDPFPPSPPM MAVKAALLYY VRRLLNPAAN NNG-KDAMVV ---------- -----AAAWR RDPFPPSPPM MAMQAALLYY VLLLLDPRRE EE--RDALVV ---------A AATTKTTT-- -GPYTTPLLA AMK-GGIIYY LCCIIYRTTG GGTEADYLTT ---------- ---------- ---------- --M-GGIIYY LCCIIYRTTG GGIEADYLTT AAVAGGGL-S SSTTQGGG-- -GPYSSPLLA AMK-GGIIYY LCCIIYGTTG GGIEADYLTT ---------- ---------- ---------- -MK-GGIIYY LCCIIYRTTG GGIEADYLTT ---------A AATTKGGG-- -GPYTTPLLA AMK-GGIIYY LCCIIYRTTG GGTEADYLTT FFTSPPPRAA AATTKGGG-- -GPYTTPLLA AMK-GGIIYY LCCIIYRTTG GGTEADYLTT ---------A AATTKGGG-- -GPYTTPLLA AMK-GG---- ---------- --TEADYLTT ---------A AATTKGGG-- -GPYTTPLLA AMK-GGIIYY LCCIIYRTTG GGTEADYLTT TTAWGGGLEA AATTKGGG-- -GPYTTPQQA AMK-GGIIYY LCCIIYRTTG GGTEADYLTT QQTEYYYTFP PPTTKGGG-- -GPYTTPLLA AMK-GGIIYY LCCIIYRTTG GGTEADYLTT ---------A AATTKGGG-- -GPYTTPLLA AMK-GGIIYY LCCIIYRTTG GGTEADYLTT HHIGVVVTAG GGKKTCCCTA AGPYTTPLLA AMEKGGLLYY VCCVVYNTTG GGINKDYLTT ---------- ---------- ---------- ---------- ---------- ---------- ---------M MMAAKGGG-- -GPYSSPLLA AMK-GGIIYY LCCIIYRTTG GGINKDYLTT ---THHHVES SS--VGGGCK KGPYSSPIIS SMS-GGLLYY VAAVVYATTG GGIEKDYLTT ---THHHVEN NNNNQGGGCK KGPYSSPLLA AMS-GGLLYY VAAVVYATTG GGIEKDYLTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMMQV VGPYTTPLLA AMS-GGLLYY VAAVVYTTTG GGIDKDYLTT -------MAG GGAAACCCGA AGPYTTPLLA AMEKGGLLYY VCCVVYNTTG GGINKDYLTT --------PG GGLLKHHH-- -GPYSSPAAA AIK-GGVVFF VAAPP--NNA AAADGDAITT ---------P PPLLKHHH-- -GPYSSPAAA AIK-GGVVFF VAAPP--HHA AARDGDAITT ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMSSSSCK KGPYTTPLLA AVRNGGLLYY VCCVVQPLLD DDEEHDYLTT ---------- ---------- ---------- -MRSGGLLYY TTTVVQPLLD DDEPHDYLTT ---------- ---------- -MPLTT---I ILISLLLLFF SWWLLHGIIR RRQYDTDRNN ----AAAA-A AAMMGPPPRA AADTQQSPPM MPKITTFFYY VTTLLGVGGM MMGDEDKLTT PPSFAAAVLA AALLAPPPGV VADTAASPPM MKKITTYYYY VTTLLGAGGV VVGDEDKLTT VVNNNPPPKK STTYYKKKKI HKVEEPIDEG GWACCSSSSS AL--GKKKPN NNRLVGLRSS VVDDDPPPKK STTYYKKKKV YKLDDPIDEG GWACCSSSSS AY--AKKKPF FFRLVALRSS IIKKKPPPGG STTYYKKKKI HTVTTPTDEG GWACCSSSSS SL--THHHAF FFRLIGLRSS IIKKKPPPGG STTYYQQQQI HTVTTPKDEG GWACCSSSSS AL--AHHHAF FFRLIGLRSS VVDDDPPPTT SKKFFQQQQI HQLIIPKDEG GWACCSSSSS AL--THHHAF FFRLIGIRSS VVDDDPPPAA SRRYYSSSSI GQVAAPADEG GWACCSSSSS CL--AHHHPH HHRLVGLRSS VVDDDSSSQQ STTFFQQQQV GVTDDPTGEG GWACCSSSSS ML--AHHHPH HHRLVDIRSS LLDDDPPPDD STTYYQQQQI GRVEEPADEG GWACCSSSAA AL--AHHHPH HHRLVGIRSS VVDDDPPPKK SQQYYQQQQV HRLPPPLDEG GWTCCSSSSS C---FDDDST TTNLLGLMSS VVDDDPPPKK SHHYYQQQQV HRLPPPLDEG GWTCCSSSSS C---FDDDST TTDLLSIISS VVDDDPPPKK SQQYYQQQQV HRLPPPLDEG GWACCSSSSS C---FDDDST TTTLLCLMSS VVDDDPPPKK SQQYYQQQQV HRLPPPLDEG GWTCCSSSSS C---YDDDIT TTTLLALISS VVDDDPPPKK SQQYYQQQQV HRLPPPLDEG GWTCCSSSSS C---FDDDST TTTLLSLISS VVDDDPPPKK SQQYYQQQQV E--------- ---------- ---------- ---------- VVDDDPPPKK SQQYYQQQQV HRLPPPLDEG GWTCCSSSSS C---FDDDST TTTLLSLISS VVDDDPPPKK SQQYYQQQQV HRLPPPLDEG GWTCCSSSSS C---FDDDST TTTLLSLISS VVDDDPPPKK SQQYYQQQQV HRLPPPLDEG GWTCCSSSSS C---FDDDST TTNLLSFISS VVDDDPPPKK SQQYYQQQQV HRLPPPLDEG GWTCCSSSSS C---FDDDST TTTLLSL--- VVDDDPPPKK SQQYYQQQQV HRLPPPLDEG GWTCCSSSSS C---FDDDST TTTLLSLISS VVDDDPPPSS STTYYQQQQV HRLPPIIDKG GWSCCSSSSS C---HDDDPS SSRLLSLLSG ---------- ---------- -----PTDEG GWTCCSSSSS C---YDDDAS SSNLLCLISS VVDDDPPPKK SSSYYQQQQV HRLPPPVDEG GWTCCSSSSS C---YDDDSS SSNLLCLISS VVDDDPPPSS STTYYKKKKV HRLPPPVDEG GWSCCSSSSS C---HDDDPS SSRLASLVSG VVDDDPPPNN STTYYKKKKV HRLPPPVDEG GWSCCSSSSS C---HDDDPS SSRLVGIVSG ---------- ---------- -----PVDEG GWSCCSSSSS C---HDDDAS SSRLLSLISG VVDDDPPPSS SSSYYSSSSV HRLPPPVDEG GWSCCSSSSS C---HDDDAS SSRLLSLISG VVDDDPPPNN STTYYQQQQV HRLPPTVDEG GWACCSSSSS C---HDDDPS SSRLLSLLSG VVNNNPPPEE STTFFQQQQV SRVDDPIDEG GWACCSSSSS C---HKKKPT TTSLVCLNSD VVNNNPPPEE STTFFQQQQI SRVDDPIDEG GWACCSSSSS C---HKKKPT TTSLVCLNSD ---------- ---------- ---------- ---------- ---------- ---MPKLSSG VVDDDPPPAA STTYYQQQQV HRTYYNKNEG GWTCCSSSSS CHVVGKKKEV VVDLLCLNSD VVDDDPPPEE STTYYQQQQI HRTFFNKDEG GWACCSSSSS CYVVSKKKTV VVDLLSLNSD PPVVVGGGQQ VLLGGSSSSV KDGPPKLDKQ QPPRRIIILL K----KKKRV VVPMQSLDGK IIRRRPPPGG STTRRQQQQV NSVSSG-NEG GFA------- ---------- --RFTGLDTN VVNNNPPPKK SQQYYKKKKV NTLSSG-NED DFD------- ---------- --RLAGLDTS IIIIKKNRRR EEEPIKKIIE EVKKKKVVVS GGYSRLLHCC PPDDDAIYIA LLGNEEEEEG IIVVKKDRRR RRRPVKKVVE VAVVVGRRRT GGYTKYYHCC PPDDDAIYIA LLGGPPPDEG IVIIKKHTTT QQQAIKKIIE EILLLAKKKT GGYSRPPHCC PPEEEGIYVT LLGGAAADDG IIIIKKDTTT KKKAIKKIIE EVFFFKKKKT GGYSRPPHCC PPDDDGIYVT LLGGGGGDNG IIVVKKELLL KKKAIKKIIE EVFFFAKKKT GGYSRPPHCC PPEEEGIYVT LLGGGGGDDG IILLKKDLLL KKKPLKKIIE TLAAAERRRT GGYSRPPHCC PPGGGGIYVA LLGNAAAEKG IILLKKDTTT QQQPVKKIID ELAAAERRRT GGYARPPHCC PPDDDGIYIA LLGSPPPEEG IIVVKKDRRR EEEPIKKIIE ELHHHRRRRT GGYSRPPHCC PPDDDGVYVA LLGSPPPEDG IVVVGGERRR AAAPLKKIIE EIQQQAKKKC NNVSNTTHCC AASSSGEVMN TTLGDDDLNG IVVVGGERRR AAAPLKKIIE EIHHHAKKKC NNLGNLLHCC AASSSGEVMS SSLGDDDPNG IVVVGGDRRR AAAPLKKIIE DIHHHAKKKC GGLGYVVHCC AASSSGEVMS TTLGDDDSNG IVVVGGERRR AAAPLKKIIE DIHHHTKKKC NNLGFFFHCC PPSSSGEVMS TTLGDDDPNG IVVVGGERRR AAAPLKKIIE DIHHHAKKKC EELAFLLHCC AASSSGEVMS SSLGDDDVNG ---------- ---------- DIHHHAKKKC EELAFLLHCC AASSSGEVMS SSLGDDDVNG IVVVGGERRR AAAPLKKIIE DIHHHAKKKC EELAFLLHCC AASSSGEVMS SSLGDDDVNG IVVVGGERRR AAAPLKKIIE DIHHHAKKKC EELAFLLHCC AASSSGEVMS SSLGDDDVNG IVVVGGERRR AAAPLKKIIE DIHHHEKKKC GGLGTPPHCC PPTTTGEVMS TTLGDDDPNG ---------- ---------- ---------- ---------- ---------- ---------- IVVVGGERRR AAAPLKKIIE DIHHHAKKKC EELAFLLHCC AASSSGEVMS SSLGDDDVNG VVVVAADRRR TTTPLKKVVE DIAAAENNNI GGLGFPPHCC AASSSGDIMS CCLGDDDKNA IVVVGGDRRR AAAPIKKVVE EVFFFWKKKC GGLANLLHCC GGCCCGEIMS SSIGDDDPNG IVVVGGDRRR AAAPIKKVVE EVFFFWKKKC GGLANPPHCC GGCCCGEIMS SSLGDDDPNG IVIIKKNRRR SSSPLKKVVD DIIIIQKKKT GGLAYPPHCC AASSSGELMS CCLGDDDKNA VVIIKKNRRR AAAPLKKVVE DISSSTKKKT GGLAYPPHCC AASSSGEIMS CCIGDDDKNA IAIIKKNRRR AAAPLKKVVD EIAAAEKKKT GGLAYPPHCC AASSSGEILS CCLGDDDENA IAIIKKNRRR AAAPLKKVVD EIAAADKKKT GGLAFPPHCC TT---GEILS CCLGDDDENA VVVVLLDRRR AAAPLKKVVE DIAAAEKKKT GGLGFPPHCC AASSSGEIMS CCLGDDDKNA IIIIEEERRR KKKILHHIIE KLHHHSLLLN --LSFPPHCC AADDDGNIMS TTLGEEEATP IVIIEEERRR EEEILHHIIE KLHHHALLLN --LSFPPHCC AADDDGNIMS TTLGEEEASP EKVVGG---- ---------- ---------- ---------- ---------- ---------- IVIIGGDRRR AAAPLKKIIE DVLLLKGGGA DDCTAPPHCC PPNNNGNIMS IIMGDDDANA IILLVVDRRR KKKPIKKIID DVLLLKSSSH NNVTAPPHCC AANNNGNIMS VVMGDDDAYA LVTTLLSWWW DDDKFPP--- DLIIIKFFFL VVLAISSHYY PPNNNTALKD GGVNEEESVP IIFFHHDSSS NNNPLKKIID FVKKKDSSSG GGVVGPPHAA PPGGGSMMIG LLSNDDDDGG IVFFHHDAAA RRRPLKKIIT FVEEEKSSSG GGVVGPPHAA PPGGGRMLIG LLSNNNNKGG PPPGLLMDHY SEPLLGWDYY ---------- YYFFLL-NEE LLVSSSSSEE WAVPNIDDGG PPPGFFLDHD TEPIIGWPYY ---------- YYFFLL-SGG MMITTTSSEE WTVPRFEEGG AAAGFFIDCE TDVLLGWPDD ---------- YYFFLL-RDD MMVSSSSSEE WALPPFNNGG PPPGFFIDCE TEVLLGWPTT ---------- YYFFLL-RDD MMVTTTSSEE WALPPFNNGG PPPGFFIDCE TEILLGYETT ---------- YYFFLL-RDD MMVSSSSSEE WGLPPFNNGG PPPGAAMDAQ SEPLLGWPYY ---------- YYGGLL-YDD LLVTTTSSEE WGTPDVDDGG PPPGFFIDHD NEVLLGWDYY ---------- YYFFLL-YDD LLLTTTSSEE WGTPRVSSGG PPPGFFVDHE SDPLLGWPQQ ---------- YYFFLL-YDD MMVTTTSSEE WGTPNIGGGG KKKSVVLDGE TEVKKGWAPP ---------- YYFFPP-HNN MMVSSSTTEE WAAPNFDDGG KKKGVVLDGE TEVKKGWEPP ---------- YYFFPP-HNN MMVSSSTTEE WAAPNFDDGG KKKGVVLDGE TEVKKGWAPP ---------- YYFFPP-HNN MMISSSTTEE WAAPNFDDGG KKKGVVLDGK TEVKKGWAPP ---------- YYFFPP-HNN MMISSSTTEE WAAPNLDDGG KKKGVVLDGE TEVKKGWAPP ---------- YYFFPP-HNN MMISSSTTEE WAAPNLDDGG KKKGVVLDGE TEVKKGWAPP ---------- YYFFPP-HNN MMISSSTTEE WAAPNLDDGG KKKGVVLDGE TEVKKGWAPP ---------- YYFFPP-HNN MMISSSTTEE WAAPNLDDGG KKKGVVLDGE TEVKKGWAPP ---------- YYFFPP-HNN MMISSSTTEE WAAPNLDDGG KKKGVVLDGE TEVKKGWSPP ---------- YYFFPP-HNN MMISSSTTEE WAAPNVNNGG ---------- ---------- ---------- ---------- ---------- ---------- KKKGLLVLP- RECSSG---- ---------- ---------- ------AAII SAHSNRTTGG AAANFFLLDS ENVKKGGPSS ---------- RRHHNNYWGG FFWSSSWWII QCCSLYTTGG KKKGVVLDGE TEVKKGWAPP ---------- YYFFPP-HNN MMISSSTTEE WGAPKFLLGG KKKGVVLDGE TEVKKGWSQQ ---------- YYFFPP-HNN MMISSSTTEE WGAPKFLLGG EEENFFLLDS DNVKKGWSLL ---------- YYFFPP-HNN MMISSSTTSS WGAPTFKKGG EEENFFLLDS ENVKKGWSLL ---------- YYFFPP-HNN MMISSSTTSS WGAPKFQQGG KKKNFFLLDS DNIKKNWSLL ---------- YYFFPP-HKK MMISSSTTSS WGAPKFKKGG KKKNLLLLDS DNIKKNWSLL ---------- YYFFPP-HKK MMISSSTTSS WGAPKFKKGG AAANFFLLDS ENVKKGWSLL ---------- YYYYPP-HKK MMISSSSSSS WGAPAFTTGG SSSNLLLDGK TEPKKGWTPP ---------- YYFFPP-RNN MMISSSTTEE WGSPNIKKGG SSSNLLLDGK TEPKKGWVPP ---------- YYFFPP-RNN MMISSSTTEE WGSPNIKKGG ---------- ---------- ---------- ---------- ---SSSIILL RGGPVVRRDD KKK-FFVFDK NELVVGWKLL ---------- YYYYPP-FNN MMVAAASSEE WGAPKFRRGG KKK-FFIFDS DNCIIGWKLL ---------- YYFFPP-FDD MMVSSSSSEE WGAPNWRRGG VVVNIIQSKH EGLSSAGEII ---------- LLNNGG-REE SSESSSDDRR PDEPIAEESS RRRAVVENDD GYVAATWDQQ VVAADDAAAV YYIIII-KNN MMLTTTSSSS FTGWSMFFGG RRRAVVETNA GYVAATWDRR IIKK--KKKY YYVVPP-KNN LLVTTTSSSS FTGWNMFFGG LLEEHHHHHL LKD-RRGGGR RIHWWLRKIH HSTTLLLGEE EENNMAAA-- ---ELRRRPP FLEECCCCCL LKEGAAGGGK KLHWWLARLY YADDLLLGQQ QQHHMVVV-- ---EVRRRPP IPEEDDDDDL LLANKKGGGR RLHWWLRRVQ QTDDLLLGAA AAHHMAAA-- ---EVRRRPP IPEEDDDDDL LLSNKKGGGR RLHWWLRRVQ QTDDLLLGAA AAHHMAAA-- ---EVRRRPP IPEEDDDDDL LLSNKKGGGK KIHWWLRKVQ QTDDLLLGAA AAHHMAAA-- ---EIRRRPP LPDDIIIIIL LLGARRGGGR RLHWWLTRLQ QEDDFFFGDD DDHHLVVV-- ---ELRRRPP VGDDEEEEEL LLAGKKGGGR RLHWWLYRLQ QTDDLLLGAA AAYYMAAA-- ---ELRRRPP LPQQIIIIIL LLNKGGGGGR RLHWWLRRLQ QADDVVVGEE EEHHMVVV-- ---ELRRRPP NAHHVVVVVE EA-GLLGGGR RIFWWWQEIQ QTQQMMMT-- --DDLIII-- ---EIRRRFP NAHHVVVVVE EA-GLLGGGH HIHWWWQEIQ QTQQMMMK-- --DDLIII-- ---EIRRRFP NADDVVVVVE EA-GLLGGGH HLHWWWQEIQ QTTTLLLQ-- --DDLIII-- ---EIRRRFP NADDVVVVVK KA-GLLGGGH HLYWWWQEVQ QTPPLLLQ-- --DDLIII-- ---EIRRRFP NADDVVVVVE EA-GLLGGGH HLYWWWQEVQ QTSSLLLK-- --DDLIII-- ---EIRRRFP NADDVVVVVE EA-GLLGGGH HLYWWWQEVQ QTSSLLLK-- --DDLIII-- ---EIRRRFP NADDVVVVVE EA-GLLGGGH HLYWWWQEVQ QTSSLLLK-- --DDLIII-- ---EIRRRFP NADDVVVVVE EA-GLLGGGH HLYWWWQEVQ QTSSLLLK-- --DDLIII-- ---EIRRRFP NADDVVVVVE EA-GLLGGGH HLHWWWQEVQ QTLLMMMP-- --DDHIII-- ---EIRRRFP ---------- ---------- ---------- ---------- ---------- ---------- RYPPAAAAAS SA-SRRAAAI IT-------- ---------- ---------- ---------- EMCCLLLLLT TA-SGGHHHI ISCDDYIVDE ESPPLLLQ-- --DDAGGGNN PPICLRRRSK KEEEVVVVVQ QA-GMMGGGS SLNWWWTRIQ QTDDLLLGEE EEDDLIII-- ---EIRRRFP KEDDVVVVVQ QA-GHHGGGS SLNWWWTRVQ QTDDLLLGKK KKDDLIII-- ---EIRRRFP DQHHVVVVVA AD-GLLGGGH HLTIILAERQ QTDDLLLGNN NNTTLLLL-- ---EIRRRFP NQHHVVVVVA AD-GLLGGGH HLHYYWPEKQ QTDDLLLGDD DDKKLLLL-- ---EIRRRFP DQHHVVVVVA AD-GLLGGGH HLHYYWPEKQ QLDDLLLGEE EETTLLLL-- ---EIRRRFP NQHHVVVVVA AD-GLLGGGH HLHYYWPEKQ QLDDLLLGPP PPTTLLLL-- ---EIRRRFP DQHHVVVVVQ QD-GLLGGGH HLHYYWPEKQ QTDDLLLGSS SSTTLLLL-- ---EVRRRFP NAHHVVVVVG GE-GLLGGGS SVHFFWDKLQ QTDDLLLPQQ QQLLALLL-- ---EVRRRFP NAHHVVVVVP PE-GLLGGGS SVHFFWDKLQ QTDDLLLPMM MMRRALLL-- ---EVRRRFP EKCCQQQQQP PE-PLLIIIC CKRYY----- ---------- ---------- ---------- HTDDCCCCCD DDRTQQGGGR RLNYYWQEFQ QTDDLLLGDD DDDDLTTT-- ---EIRRRFP KVDDLLLLLE EDMSQQGGGR RLNYYWSTYQ QTDDLLLGSS SSDDITTT-- ---EIRRRFP EFLLKKKKKK KTGPLLPPPH HVAVV----- ---------- ---------- ---------- MQDDAAAAAE EAMKRRGGGT TIVWWLHQKK KVNNVVVPGG GGPP------ ---EIRRRFS MADDPPPPPE EAMKHHGGGT TVVWWLHQKK KVDDVVVPGG GGPP------ ---EIRRRCE TKLGGFIINN VVVVLSSIIW WL--DDKKKW AAKVIIEEII PPPEPLEEG- LLLPELKAVP TKLGGFVVNN VVVLLSSIIW WL--DDKKKW AARVIIDDII EEEQPFEEG- LLLPPLKMVP VREGGFVVGG VVVVLGGIIW WT--GGKKKF VVKTAATTII PPPEPATTAD LLLPPLQAVP VREGGFVVGG VVVVLAAIIW WT--GGKKKF AAKTAATTII PPPEPAPPKE LLLPPLQAVP SKDGGFCCGG VVVVLGGIIF FTKKDDTTTF AAKTIITTII DDDVPADDAD LLLPDLKACP TKAGGFVVNN VVVILSSIIW WT--KKKKKW VVKVIIEEII PPPEAADDPD LLLPPLKAVP TKAGGFMMNN VVVVLAAIIW WL--NNSSSW LLKVIIDDII PPPEPASSED LLLPPLKAVP ARTGGFVVGG VVVVLAAVVW WL--NNSSSW IIKVIIEEII PPPEPAEEPD LLLPPLKAVP SATGGFVVGG AAALQFFKKN NE-------- ----TTWWSS VVVKVIQQVP KKKKVGWEMP DATGGFVVGG AAALQFFKKN NE-------- ----TTWWSS VVVKVIQQVP KKKKVGWEMP DAAGGFVVGG AAALQFFKKN NQ-------- ----TTWWSS VVVKVIQQVP KKKKVGWEMP DAAGGFVVGG AAALQFFKKN NE-------- ----TTWWSS AAAKVIQQVP KKKKVGWEMP DAAGGFVVGG AAALQFFKKN NE-------- ----TTWWSS VVVKVIQQVP KKKKVGWEMP DAAGGFVVGG AAALQFFKKN NE-------- ----TTWWSS VVVKVIQQVP KKKKVGWEMP DAAGGFVVGG AAALQFFKKN NE-------- ----TTWWSS VVVKVIQQVP KKKKVGWEMP DAAGGFVVGG AAALQFFKKN NE-------- ----TTWWSS VVVKVIQQVP KKKKVGWEMP AASGGFVVGG AAALQFFKKN NE-------- ----TTWWSS VVVKVIEEVP KKKKVGWEMP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NINDDYDDVV EEEVRGGDDP PD-------- ----AAVVVV LLLRKLDDLY AAAVVKFSLS DAAGGLVVGG AAALFFFKKE EK-------- ----KKWWAA AAAKVIKKVP KKKKVGWEMP DADGGLVVGG AAALFFFKKE EK-------- ----KKWWAA AAAKVIQQVP KKKKVGWEMP AKDGGFVVGG AAALIFFKKT TQ-------- ----SSWWSS HHHLAIPPVK LLLKVNWEMP AKDGGFVVGG AAALIFFKKT TQ-------- ----SSWWNN HHHIVISSVE LLLKVNWEMP SKDGGYVVGG AAALIFFKKN NS-------- ----TTWWSS YYYIVISSVK LLLKVNWEMP SKDGGFVVGG AAALIFFKKN NS-------- ----TTWWSS HHHVVISSVK LLLKVNWEMP SKDGGYVVGG AAALVFFKKT TA-------- ----SSWWSS HHHVAISSIK LLLKVNWEMP TSEAAFVVGG AAALFIIPPV VE-------- --T-TTHHAA AAALVAFFIP KKKKVGWEMP TSEAAFVVGG AAALFIIPPD DE-------- --K-VVQQTT AAALVATTIP KKKKVNWDMP ---------- ---------- ---------- ---------- ---------- ---------- RENGGYVVGG AAAFXXX--- ---------- ---------- ---------- ---QGNGMMG KKAGGFVVGG AAALFFFKKK KS-------- --EFEEAAKK KKKIDIPPGK VVVDTSGDMG ---------- ---------- ---------- ---------- ---------- ---------- NANAAFSSTT AAALWIIEED DD-------- ---------- ------EEWQ KKKAVDIADI AHNCCFTTSS AAALWIIEED DG-------- ---------- ------EEWQ KKKAVDIAKV TDIISDDKKL LLSLWWGGII IIGEEQSSNP LTGGGGGGFH RRAH------ ---------- TDIISDDRRV VVSLWWGGLL LLGEEQTTNP LAGGGGGGYH RREH------ ---------- TDILSDDRRV VVSCWWGGTT TTGEEQSSDP LAGGGGGGAR RRAH------ ---------- TDILSDDRRV VVSCWWGGTT TTGEEQSSDP LAGGGGGGAR RRTH------ ---------- TDILSDDKKV VVACWWGGLL LLGEEQSSDP LTGGGGGGVK KKTH------ ---------- TDILSDDRRV VVSCWWGGTT TTGDDQSSDP LTGGGGGGVS RRAH------ ---------- TDILSDDRRV VVSCWWGGTT TTGEEQSSDP LTGGGGGGVR RRAH------ ---------- TDILSDDRRV VVSCWWGGTT TTGEEQSSDP HTGGGGGGVR KKAH------ ---------- TDILSDDRRF FFSNWWLLHH HHGDDQSSNP LTGGGGGGIV RRGSVVLL-D QQQQEEELQQ TDILSDDRRF FFSNWWLLHH HHGDDQSSNP LTGGGGGGIV KKGSVVLL-D QQQQEEELQQ TDILSDDRRF FFSNWWLLHH HHGDDQSSDP LTGGGGGGIV KKGPVVLL-D QQQQEEELQQ TDILSDDHHF FFSNWWLLHH HHGDDQSSDP LTGGGGGGIV KKDPVVLL-D QQQQEEELQQ TDILSDDRRF FFSNWWLLHH HHGDDQSSDP LTGGGGGGIV KKGPVVLL-D QQQQEEELQQ TDILSDDRRF FFSNWWLLHH HHGDDQSSDP L--------- ---------- ---------- T--------- ---------- ---------- ---------- ---------- ---------- TDILSDDRRF FFSNWWLLHH HHGDDQSSDP LTGGGGGGIV KKGPVVLL-D EEEEEEELQQ TDILSDDRRF FFNNWWLLHH HHGDDQSSDP LVGGGGGGIV KKGPVVLL-D QQQQEEELQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPAIFSDLLF FFLS------ ---------- ---------- ---------- ---------- TDIISDDRRF FFSNWWLLHH HHGDDQTTDP LVGGGGGGIL RRGPVVLL-D KKKKDDDLQQ TDIISDDRRF FFSNWWLLHH HHGDDQTTDP LVGGGGGGIQ RRGPVVLL-D KKKKEEELQQ TDFISDDRRF FFVNWWLLHH HHGDDQEEDP LTGGGGGGIQ KKGPAAII-E DDDDGGGKQQ TDFISDDRRF FFVNWWLLHH HHGDDQEEDP LTGGGGGGIQ KKGPAAVV-D DDDDGGGEQQ TDFISDDRRF FFVNWWLLHH HHGDDQEEDP LTGGGGGGLQ KKGPAAVV-E DDDDGGGNQQ TDFISDDRRF FFVNWWLLHH HHGDDQEEDP LTGGGGGGLQ KKGPAAVV-E DDDDGGGNQQ TDFISDDRRL LLVNWWLLHH HHGDDQEEDP LAGGGGGGLQ KKGEYYVV-E DDDDDDDKQQ TDIISDDRRV VVSCWWLLHH HHGDDQSSDV LNSSSGGGVH TTENVVLL-G EEEEKKK-PP TDIISDDRRV VVSCWWLLHH HHGDDQSSDP LNSSSGGGIH SSETVVLL-E DDDDHHHDEE ---------- ---------- ---------- ---------- ---------- ---------- TDIISDDRRF FFSNWWRRHH HHGDDQSSDP LTGGGGGGIQ RRDPVVLL-D PPPPEEELAA SDIISDDRRV VVNCWWRRHH HHGDDQTTDP LTGGGGGGIC SSDPIIVVED KKKKEEELRR ---------- ---------- ---------- ---------- ---------- ---------- VDIIADDQQI IINSFFMMDD DDGKKLSSDP QIYYYRRRVN ---------- ---------- VDIISDDSSV VVNTFFMMDD DDGKKLSSDP QVYYYAAAVN ---------- ---------- ---------- AAHHTGGAPQ LEEIISSRRD DVVVYVTNSS LSTTWDDNQF FYGGLKKKKW ---------- SSAATGGAPQ ISSVVSSRRD DVVVYITNSS LSSSWNNNQF FYGGLRRRRW ---------- NNRRAGGGPQ VEEIISSRRD DVVVYWTNSS LSTTWDDDQF FYGGVPPPPA ---------- NNKKAAAGPQ VEEIISSRRD DVVVYWTNSS LSTTWDDDQF FYGGVPPPPV ---------- NNKKGYYGPQ VEEIISSRRD DVVVYWTNSS LSTTWDDEQF FYDDRGGGGA --------AA KKGGNGGGPQ VEEIISSRRD DVVVYFTNSS LGAAVDDPQF FYGGIDDDDW --------AA TTAANGGGPQ VEEIISSRRD DVVVYFTNSS LRAAWDDEQF FYGGIKKKKW ---------- AAGGNGGGPQ VEEVVSSRRD DVVVYFSNSS LASSWDDEQF FYGGIRRRRW PPEEEPPVVV KKKKPGGGPQ IQQLLSSLLD DLLLYATTSS LSDDWDDKQF FYDDLIIIIE PPEEEPPVVV KKKKPGGGPQ IQQLLSSLLD DLLLYVTTSS LSAAWDDKQF FYNNLIIIIE PPEEEPPVVV KKKKPGGGPQ IQQLLSSLLD DLLLYVTTSS LSAAWDDKQF FYDDLIIIIE PPEEEPPVVV KKKKAGGGPQ IQQLLSSLLD DLLLYVTTSS LSAAWDDKQF FYDDLIIIIE PPEEEPPVVV KKKKAGGGPQ IQQLLSSLLD DLLLYITTSS LSAAWDDKQF FYDDLIIIIE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPEEEPPVVV KKKKAGGGPQ IQQLLSSLLD DLLLYITTSS LSAAWDDKQF FYDDLIIIIE PPEEEPPVVV KKKKPGGGPQ IQQLLSSLLD DIIIYVTTSS LSDDWDDKQF FYDDLIIIIE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPDDDPPIVV KKKKPGGGPQ IQQLLSSLLD DLLLYVTNSS LSKKWDDKQF FYDDMIIIIE PPDDDPPTVV KKKKPGGGPQ IQQLLSSLLD DIIIYVTSSS LSIIWDDKQF FYDDLLLLLE SSDDDVVEII QQQQRGGGPQ IQQLLTTLLD DLLLYVTNSS LSAAWDDKQF FYGGLVVVVK SSDDDVVEII QQKKRGGGPQ IQQLLSSLLD DLLLYVTNSS LSAAWDDKQF FYKKLVVVVQ FFDDDVVQII KKKKRGGGPQ IQQLLSSLLD DLLLYATNSS LSAAWDDRQF FYEELMMMMK FFEEEVVQII KKKKRGGGPQ IQQLLSSLLD DLLLYATNSS LSAAWVVVSF FYEEIMMMMK YYSSSVVQVV KKHHRGGGPQ IQQLLSSLLD DIIIYVTNSS LSRRWDDEQF FYDDLVVVVK IIEEEAAYVV KKRREGGGPQ LQQLLSSLLD DLLLYVTTSS LKKKWDDDQF FYEEHVVVVS IIPPPAAYVV KKRREGGGPQ LQQLLSSLLD DLLLYVSTSS LKKKWDDDQF FYEENVVVVS ---------- -----GGGPA IQQLLSSVVD DLLLYVTNSS FSTTWDDKQF FYNNVVVVVE PPEEEPPFLL KKRRLGGGPQ LQQLLSSLLD DLLLYVSSSS LSPPWDDKQF FYEEMVVVVA PPPPPAAYVV KKRREGGGPQ LQQLLSSLLD DLLLYVSSSS LSPPWDDKQF FYKKMVVVVQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VSSQQSSWWD DVVVYFSSSS LANNWDD--- ---------K ---------- ---------- VSSSSSSWWD DLLLYYTSSS LANNWDD--- ---------K MKNNNNAAAN N----PSSGG GLEIDKEFFF FFVDFFGGG- --AAQVVVVL GASSSSS--- MKNNNNVVVN N----PEEGG GLELEKEFFF FFVDFFGGG- --AAQVVVVL GASSTSS--- QLHHHHAAAG G----PDDGG GLTLADDYYY WWVEFFPPPG --YYQIIIIL GCSSTSSSSV EMNNNNVVVG G----GNNGG GLELDKDYYY FFVSFFPPPG --YYQIIIIL GCSSTSSSSV MMNNNNVVVG G----ENNGG GLTLDKDFFF WWVDFFPPPG --YYQIIIIL GCSSTSSSSV MKDDDDAAAG G----PNNGG GIEFDPKFFF FFLEWWPPPG --HHQVVVVL GCSSSSS--- MKDDDDVVVN N----PDDGG GMQFDPNFFF FFVDFFGGG- --QQQIIIIL GASSSSS--- IKEEEEAAAD D----PGGGG GLSLDPGFFF FFTEVVGGGG --LLQIIIIL GSSSSSSSS- GVLLLLQQQV VVDTTVNNGG GLKLNPNFFF LLVDFFGGGE PLAAELLLLY GCSSSII--- GVLLLLQQQI IVDTTANNGG GLKLNPNFFF LLVDFFGGGE PLAAELLLLY GCSSSII--- GVLLLLQQQI IVDTTVKKGG GLKLNPNFFF LLVDFFGGGE PLAAELLLLY GCSSSII--- GVLLLLQQQI IVDTTVKKGG GLTLNPNFFF LLVDFFGGGE PLAAELLLLY GCSSSII--- GVLLLLQQQV VVDTTVKKGG GLKLNPNFFF LLVDFFGGGE PLAAELLLLY GCSSSII--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GVLLLLQQQV VVDTTVKKGG GLKLNPNFFF LLVDFFGGGE PLAAELLLLY GCSSSII--- GVLLLLQQQI IVDTTVKKGG GLKLNPNFFF LLVDFFGGGE PLAAEIIIIY GCTTSII--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GVLLLLQQQI IVDTTEKKGG GLKLNPNFFF LLVDFFGGGE PGVVELLLLY GCSSSII--- GVLLLLQQQI IVDTTKKKGG GLKLNPNFFF LLVDFFGGGE PDVVEIIIIY GCTTSII--- GHLLLLQQQI IVDTTEKKGG GLKINPNFFF FFVDFFGGGE PDAAEMMMMY GCTTSII--- GHLLLLQQQI IVDTTENNGG GLKINPNFFF FFVDFFGGGE PDSSEMMMMY GCTTSII--- GHIIIIQQQI IVDTTEKKGG GLSINPNFFF FFVDFFGGGE PEAAEMMMMY GCTTSII--- GHIIIIQQQI IGDTTEKKGG GLTINPDFFF FFVDFFGGGE PDSSEMMMMY GCTTSII--- GHLLLLQQQI IVDTTEKKGG GLSINPNFFF FFVDFFGGGE PESSEMMMMY GCTTSII--- GTVVVVQQQV VIDPPESSGK KMEINRDFFF LLIDFFGGGI EGYYEMMMMY GCTTSII--- GTLLLLQQQI IVDPPITTGH HMVINKNFFF LLIDFFGGGV PGYYEMMMMY GCTTSII--- GVLLLLQQQI IVDTTEKKGG GLTVNKNFFF LLVDFFGGGE PNCCDIIIIF GSTTSII--- GTVVVVQQQL LIDVVENNGG GMKLNENFFF LLVDFFGGGE PYGGEMMMM- ---------- GHVVVVLLLI IVDTTVNNGG GISLNEDFFF LLVDFFAAAE PYSSEMMMMY GCTTSIIDDA ---------- ---------- ---------- ---------- ---------- ---------- GDAAAAQQQY YKAYYNWWDG GKELVEDFFF AAVDFFYYYL GL--IMMMMF SLYYS----- GDEEEEQQQF FKLYYYWWDG GKELKEQFFF AAIDFFYYYE KL--QMMMMF RLYYAPPNNR ------- ------- VRRR--- V------ V------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- A------ ------- ------- RVVVRRE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNSSAAAKKK QSSEETPRVP TTTTGGAARR LLLGGMMQSL LLLPTQLLLS LLLLTPPPVR gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RAYAAAWTTT FFSSSSAAAI IQVLSPRSSK TTRRVVPPPL LVVEEISKVP PQQAAAVVAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------LL ---------- ---------- ---------- ---------- ---------- ---------- --MRRRAPPP TTLPPPPPPL LNNRTPHPPA SSPPHHPPPV VPPLLTRYTN NPPPRRLLPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MA IIVVPKKPTF FFKKAKKPPP PEAAVACCLY ---------- ---------- ---------- MMAAKKKPTF FFRRARRPPP PEAAVAAALY ---------- ---------- ---------- --MMSRRPTF FFEEAQQPAA AEAATLLLLS ---------- ---------- ---------- --MMTRRPTF FFKKAEEPAA AEAATLLLLS ---------- ---------- ---------- --MMTRRPTF FFKKAEEPVV VEAATLMMLS ---------- ---------- ---------- MMAATKKPSF FFRRAKKPPP PEAAVAMMFD ---------- ---------- ---------- MMVVTRRPTF FFRRAKKPAA AEAAVVRRLN ---------- ---------- ---------- MMAASRRPTF FFKKAQQPRR REGGVALLLD ---------- ---------- -------ATK CCTTK--PGY YYEEM--PRR REVVLPCCIY ---------- ---------- ---------- ---------- -------PRR REVVLPCCIY HHHWLPPPGK GGAAALLLIP PPPL-AASTQ CCGGK--PGY YYEEM--PRR REVVLPCCIY ---------- ---------- ---------- ---------- ----M--PRR REIILPCCIY ---------- ---------- -------ATK CCGGN--PGY YYEEM--PRR REVVLPCCIY -----AEERA GGAAFLLLQV VVVRASSATK CCGGN--PGY YYEEM--PRR REVVLPCCIY ---------- ---------- -------ATK CCGGN--PGY YYEEM----- ---------- ---------- ---------- -------ATK CCGGN--PGY YYEEM--PRR REVVLPCCIY MMMGLGKKEE GGHHTQQQPF FFFLEDDATK CCGGD--PGY YYEEM--PRR REVVLPCCIY KKKNSQGGCL FFDDQNNNTL LLLTFTTPTK CCGGN--PGY YYEEM--PRR REVVLPCCIY ---------- ---------- -------ATK CCGGN--PGY YYEEM--PRR REVVLPCCIY PPPHARHHSL LLQQHMMMEA AAATAAAGKT CCCCHAAPGY YYEEMKKPRR REVVVTCCVY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MAK CCGGS--PGY YYDDM--PRR REVVLPCCIY ---------- -----MMMAV VVVVEKKS-V NNGGCKKPGY YYEEM--PRR REIIVTAAVY ---------- -----MMMGV VVVVEKKNNQ QQGGCKKPGY YYEEM--PRR REIIVTAAVY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRMMLVVPGY YYAAM--PSS SEIIVTAAVY ---------- ---------- ---MAAAGAA CCCCGAAPGY YYEEMKKPRR RELLVTCCVY ---------- ---------- ----PNNGLK CCHHG--PGY YYDDI--PRR RELLVTAAP- ---------- ---------- -------PLK CCHHG--PGY YYDDI--PRR RELLVTAAP- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MS EESSKKKPGY YYDDVNNPVV VELLVVCCVQ ---------- ---------- ---------- ---------- ----MSSPRR RELLTVTTVQ ---------- ---------- ---------- -------PGL LLDDLSSDDD DRYYSNWWLH ----MKRRRE GG-------- ---A-AAAMG LLPPFAADET TTYYPIIGQQ QEVVVWTTLG ----MKRRFI SSGGPMMMHA AAAVLAAALA AAPPAVVDET TTYYKIIGQQ QEVVVWTTLG IINNAADDFF IIAAVVVVPP SSSYSIVVKK VLLYNDELFW WASA-PPNNG GGRRFFFIIV VVNNPPDDFF LLAAVVVVPP SSSYGVIIKK LLLYGDELFW WASA-PPNNA AARRYYYIIV ----PPDDAA LLAAVIIVPP SSSYGIVVTT VMMNGDEFFW WASS-PPLLT TTRRFFFIII ----PPDDAA LLAAVIIVPP SSSYGIVVTT VMMNGDEFFW WASA-PPLLA AARRYYYIII ----PPDDGG LLAAVVVVPP SSSFGIVVQQ LMMNGDEFFW WASA-PPLLT TTRRYYYIII ----PPDDAA IIAAVVVVPP SSSYAIVVQQ VMMHGDELFW WASC-PPNNA AARRYYYVVV GG--PPDDAA MMCCVVVVSS SSSFGVVVVV TMMYGGELFW WASM-PPNNA AARRYYYVVV ----PPDDAA LLGGVLLLPP SSSYAIVVRR VMMNADELFW WAAA-PPYYA AARRYYYIIV TTEEPPDDYY LLAATVVVPP SSSYSVIIRR LMMYKDELSW WTSC-----F FFNNKKKIIL IIEEPPDDYY LLAATVVVPP SSSYSVIIRR LMMHKDELSW WTSC-----F FFDDKKKIIL IIEEPPDDYY LLAATVVIPP SSSYCVIIRR LMMNRDELSW WASC-----F FFTTKKKMML IIEEPPDDYY LLAATVVVPP SSSYCVIIRR LMMHKDELSW WTSC-----Y YYTTKKKVVL TTEEPPDDYY LLAATVVVPP SSSYCVIIRR LMMNKDELSW WTSC-----F FFTTKKKVVL TTEEPPDDYY LLAATVVVPP SSSYCVII-- ---------- ---------- ---------- TTEEPPDDYY LLAATVVVPP SSSYCVIIRR LMMNKDELSW WTSC-----F FFTTKKKVVL TTEEPPDDYY LLAATVVVPP SSSYCVIIRR LMMNKDELSW WTSC-----F FFTTKKKVVL TTEEPPDDYY LLAATVVVPP SSSYSVIIRR LMMYKDELSW WTSC-----F FFNNKKKVVL TTEEPPDDYY LLAATVVVPP SSSYCVIIRR LMMNKDELSW WTSC-----F FFTTKKKVVL TTEEPPDDYY LLAATVVVPP SSSYCVIIRR LMMNKDELSW WTSC-----F FFTTKKKVVL IINNLLDDYY LLAATVVLPP SSSYSVIIRR LVVHGDKLSW WSSC-----H HHRRFFFIIL ---------- ---------- ---------- -MMNNDELSW WTSC-----Y YYNNKKKIIL IINNPPDDYY LLAATVVVPP SSSYSVIIRR LMMNNDELSW WTSC-----Y YYNNKKKIIL IIEEPPDDYY LLAATVVVPP SSSYSVIIRR LVVYGDELTW WSSC-----H HHRRFFFIIA IIEEPPDDYY LLAATVVLPP SSSYSVIIRR LVVYGDELTW WSSC-----H HHRRFFFIIV ---------- ---------- ---------- -MMFGDELSW WSSC-----H HHRRYYYVVL IIDDPPDDYY LLAATVVVPP SSSYSVIIRR LMMFGDELSW WSSC-----H HHRRYYYVVL IINNPPDDYY LLGGTVVVPP SSSYSVIIRR LVVHGDELSW WASC-----H HHRRFFFIIL AADDPPDDAA IIFFTVVVPP SSSFCVIIRR VVVHGDEVTW WASC-----H HHSSHHHIIV RRDDPPDDAA IIFFTVVVPP SSSFCIIIRR VVVNGDEVTW WASC-----H HHSSHHHIIV ---------- ---------- ---------- ---------- ---------- -------VVP EEEEGGDDYY LLAATVVVPP SSSYCVIIRR TTTSHNELSW WTSCVPP--G GGDDRRRVVL EEPPGGDDYY LLSSTVVVPP SSSYCIVVRR TTTRGDELSW WASCVDDEES SSDDRRRVVL QQYYIITTDD RRKKNPPMGG VVVGGVLLDD GVVVEDKESP PPLK------ --PPQQQLLQ GGDDQQDDKK LLVVTIILPP SSSRGVIISS VVVGRNEAGF FA-------- --RRFFFWWT GGDDQQDDKK LLVVTVVAPP SSSYGVVVTT LVVGRNEASF FD-------- --RRYYYWWA VVLRSIIIIY IDDTPNPKKK KKKVVEPPPP VKKKSLLLTV VHHCGDAAAI IISSSLNN-- VVLRSIIIIY VDDTPDKAAK KKKIIEPPPP AVVGTYYYTV VHHCGDAAAI IISSSLGG-- IILRSIIIIY IDDTPHPRRK KKKIIEPPPP ILLATPPPTV VHHCGEGGGI IISSSLGGGG IILRSIIIIY IDDTPDPKKK KKKIIEPPPP VFFKTPPPTI IHHCGDGGGI IISSSLGGGG IIIRSIIIIY VDDV-EPKKK KKKIIEPPPP VFFATPPPTI IHHCGEGGGI IISSSLGGGG VVLRSIIIIY LDDTPDPFFK KKKVVEPPPP LAAETPPPTV VHHCGGGGGI IITTTLNN-- VVIRSIIIIT LDDTPDPKKK KKKVVDPPPP LAAETPPPTV VHHCGDGGGI IISSSLSS-- VVIRSIIIIH VDDTPDPRRK KKKVVEPPPP LHHRTPPPTI IHHCGDGGGV VVSSSLSS-- LLLMSIIIIY VDDVSEPKKK KKKVVEAAAA IQQACTTTTS SHHCLSGGGE EEVVVTGG-- LLIISIIIIY VDDVSEPKKK KKKVVEPPPP IHHACLLLTS SHHCLSGGGE EEIIISGG-- LLLMSIIIIY VDDVSDPKKK KKKVVEAAAA IHHACVVVTS SHHCLSGGGE EEIIITGG-- LLLISIIIIY VDDVTEPKKK KKKVVEPPPP IHHTCFFFTS SHHCLSGGGE EEVVVTGG-- LLLISIIIIY VDDVSEPKKK KKKVVEPPPP IHHACLLLTS SHHCLSGGGE EEIIISGG-- ---------- ---------- ------PPPP IHHACLLLTS SHHCLSGGGE EEIIISGG-- LLLISIIIIY VDDVSEPKKK KKKVVEPPPP IHHACLLLTS SHHCLSGGGE EEIIISGG-- LLLISIIIIY VDDVSEPKKK KKKVVEPPPP IHHACLLLTS SHHCLSGGGE EEIIISGG-- LLFISIIIIY VDDVTEPKKK KKKVVEAAAA IHHECPPPTS SHHCLTGGGE EEIIITGG-- LLL------- ---------- ---------- ---------- ---------- ---------- LLLISIIIIY VDDVSEPKKK KKKVVEPPPP IHHACLLLTS SHHCLSGGGE EEIIISGG-- LLLLGVVVVY VDDTTDPSSK KKKVVESSSS IAAEIPPPTS SHHCLSGGGD DDIIICGG-- LLLISIIIIY VDDVTDPRRK KKKTTEPPPP VFFWCLLLTS SHHCLCGGGE EEIIISGG-- LLLISIIIIY VDDVSDPRRK KKKTTEPPPP VFFWCPPPTS SHHCLCGGGE EEIIISGG-- AALVGIIIIY IDDTTNPSSK KKKVVDPPPP IIIQTPPPTS SHHCLSGGGE EEIIICGG-- VVIVGVVVVY IDDTTNPSSK KKKVVEPPPP ISSTTPPPTS SHHCLSGGGE EEIIICGG-- LLLIGIIIIY IDDTENPSSK KKKYYDPPPP IAAETPPPTA AHHCLSGGGE EEVVVCGG-- LLLIGIIIIY IDDTENPSSK KKKYYDPPPP IAADTPPPTA AHHCR-GGGE EEVVVCGG-- LLLLGVVVVY VDDTKDPAAK KKKVVEAAAA IAAETPPPTS SHHCLSGGGE EEIIICGG-- VVLNDIIIIY INNVNE-YYH HHHTTEPPPP LHHSNPPPTS SHHCLDGGGN NNIIITGG-- VVLNDIIIIY INNVNE-YYH HHHTTEPPPP LHHANPPPTS SHHCLDGGGN NNIIITGG-- PPLSGEEEEG VFFVG----- ---------- ---------- ---------- ---------- LLLNDIIIIF IDDTTDPKKK KKKVVEGGGG VLLKAPPPTT THHCLNGGGN NNIIIIGG-- LLLNDIIIIY LDDVTDPEEK KKKTTDGGGG VLLKHPPPTT THHCLNGGGN NNIIIVGG-- QQLDKLLLLY TTTSYSAQQP PPP------- LIIKLSSSTA ADDYQNTTTA AAQQQGNN-- TTLDNIIIIF FDDVSDPKKK KKKTTDTTTT VKKDGPPPTF FFFALGSSSM MMTTTLNN-- AALDSIIIIF FDDVSDPVVK KKKTTTDDDD VEEKGPPPTL LYYALGRRRM MMTTTLNN-- -G--GGPGGG GIILLMDHHY YYYSPPWWEI IDGQYYYYYY ---------- ------LLYY -GRRGGPGGG GIIFFLDHHD DDDTPPWWEV VYGQYYYYYY ---------- ------FFYY GGTTGGAPPP GIIFFIDCCE EEETVVWWEI IDGQDDDDDD ---------- ------KKYY GGTTGGPPPP GVVFFIDCCE EEETVVWWEI IDGQTTTTTT ---------- ------LLYY GGTTGGPPPP GIIFFIDCCE EEETIIYYEM MDGQTTTTTT ---------- ------KKYY -G--GGPGGG GIIAAMDAAQ QQQSPPWWEV VEGQYYYYYY ---------- ------FFYY -G--GGPGGG GIIFFIDHHD DDDNVVWWEI IDGQYYYYYY ---------- ------LLYY -G--GGPGGG GVVFFVDHHE EEESPPWWEV VEGQQQQQQQ ---------- ------LLYY -QGGGGKGGG SFFVVLDGGE EEETVVWWEK KPGSPPPPPP ---------- ------MMYY -QGGGGKGGG GFFVVLDGGE EEETVVWWEK KPGAPPPPPP ---------- ------MMYY -KGGGGKGGG GFFVVLDGGE EEETVVWWEQ QPGAPPPPPP ---------- ------MMYY -EGGGGKGGG GFFVVLDGGK KKKTVVWWEQ QPGAPPPPPP ---------- ------LLYY -KGGGGKGGG GFFVVLDGGE EEETVVWWER RPGAPPPPPP ---------- ------SSYY -KGGGGKGGG GFFVVLDGGE EEETVVWWER RPGAPPPPPP ---------- ------LLYY -KGGGGKGGG GFFVVLDGGE EEETVVWWER RPGAPPPPPP ---------- ------LLYY -KGGGGKGGG GFFVVLDGGE EEETVVWWER RPGAPPPPPP ---------- ------LLYY -KGGGGKGGG GFFVVLDGGE EEETVVWWER RPGAPPPPPP ---------- ------MMYY ---------- ---------- ---------- ---------- ---------- ---------- -KGGGGKDDD GSSLLVLPP- ---RCC---- ---------- ---------- ---------- -EGGAAAGGG NGGFFLLDDS SSSEVVGGSN NRFISSSSSS ---------- ------KKRR -YGGGGKGGG GFFVVLDGGE EEETVVWWEA AEEAPPPPPP ---------- ------FFYY -CGGGGKGGG GFFVVLDGGE EEETVVWWEV VEEAQQQQQQ ---------- ------FFYY -DGGAAEGGG NGGFFLLDDS SSSDVVWWEK KPHPLLLLLL ---------- ------FFYY -DGGAAEGGG NGGFFLLDDS SSSEVVWWEK KPHPLLLLLL ---------- ------FFYY -EGGAAKGGG NGGFFLLDDS SSSDIIWWEK KPHPLLLLLL ---------- ------FFYY -EGGAAKGGG NGGLLLLDDS SSSDIIWWEK KPIPLLLLLL ---------- ------YYYY -EGGAAAGGG NGGFFLLDDS SSSEVVWWEK KPHPLLLLLL ---------- ------FFYY -NGGPPSGGG NFFLLLDGGK KKKTPPWWPA ADKVPPPPPP ---------- ------FFYY -DGGPPSGGG NFFLLLDGGK KKKTPPWWPA ADKVPPPPPP ---------- ------FFYY ---------- ---------- ---------- ---------- ---------- ---------- -EGGAAKGGG -DDFFVFDDK KKKNLLWWSR RGRALLLLLL ---------- ------CCYY -EGGAAKGGG -DDFFIFDDS SSSDCCWWTK KGKALLLLLL ---------- ------CCYY -LSSPPVLLL NGGIIQSKKH HHHELLGGEA ASFEIIIIII ---------- ------LLLL -DHHGGRTTT ALLVVENDDD DDDGVVWWMP PTDMQQQQQQ GGAAAVVGDD DVAADGYYYY -DHHGGRTTT ALLVVETNNA AAAGVVWWIP PTGLRRRRRR GGAAATTG-- -YAADGYYYY DDFWNNL-PN EELEEAAVVV P--TIEDDKL LLEHHH---R YGGGNNRHWD DRRRKRISST DDFWNNL-PS GGMEETTVVV P--CFEEESL LLECCCGGGA YGGGNNKHWD DARRRHLAAD DDFWNNL-PR DDMEEAALLL P--QFENNVP PPEDDDNNNK YGGGHHRHWD DRRRRNVTTD DDFWNNL-PR DDMEEAALLL P--QFENNVP PPEDDDNNNK YGGGHHRHWD DRRRRNVTTD DDFWNNL-PR DDMEEGGLLL P--QFENNVP PPEDDDNNNK YGGGHHKHWK KRRRKNVTTD DDGWHHL-GY DDLEEGGTTT P--MVEDDVP PPDIIIAAAR YGGGRRRHWD DTRRRHLEED DDFWHHL-GY DDLEEGGTTT P--MVESSLG GGDEEEGGGK YGGGHHRHWD DYRRRHLTTD DDFWHHL-GY DDMEEGGTTT P--MIEGGDP PPQIIIKKKG YGGGRRRHWD DRRRRHLAAD DDFWQQP-RH NNMEEAAAAA P--VFKDDPA AAHVVVGGGL YGGGSSRFWD DQHHEIITTQ DDFWQQP-RH NNMEEAAAAA P--VFKDDPA AAHVVVGGGL YGGGSSHHWD DQHHEIITTQ DDFWQQP-RH NNMEEAAAAA P--VFRDDPA AADVVVGGGL YGGGSSHHWD DQHHEIITTT DDFWQQP-RH NNMEEAAAAA P--VLRDDPA AADVVVGGGL YGGGSSHYWD DQRREIVTTP DDFWQQP-RH NNMEEAAAAA P--VLRDDPA AADVVVGGGL YGGGSSHYWD DQHHEIVTTS DDFWQQP-RH NNMEEAAAAA P--VLRDDPA AADVVVGGGL YGGGSSHYWD DQHHEIVTTS DDFWQQP-RH NNMEEAAAAA P--VLRDDPA AADVVVGGGL YGGGSSHYWD DQHHEIVTTS DDFWQQP-RH NNMEEAAAAA P--VLRDDPA AADVVVGGGL YGGGSSHYWD DQHHEIVTTS DDFWQQP-RH NNMEEAAAAA P--VVQNNPA AADVVVGGGL YGGGKKHHWD DQHHEIVTTL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---IIAAHHH S--LRLTTDY YYPAAASSSR VAAAGGI--- ---------- TTHLEENYAW GGFIICCCCC S--FYTTTLM MMCLLLSSSG VHHHVVICDN NIRRVIDSSP DDFWQQP-RH NNMEEGGAAA P--AFALLME EEEVVVGGGM YGGGHHSNWD DTHHRRITTD DDFWQQP-RH NNMEEGGAAA P--AFALLME EEDVVVGGGH YGGGHHSNWD DTHHRLVTTD DDFWQQP-RH NNMSSGGAAA P--AFTKKLQ QQHVVVGGGL YGGGRRHTIQ QAGGELRTTD DDFWQQP-RH NNMSSGGAAA P--AFLQQLQ QQHVVVGGGL YGGGRRHHYS SPGGEIKTTD DDFWQQP-RH KKMSSGGAAA P--AFSKKLQ QQHVVVGGGL YGGGSSHHYS SPGGEMKLLD HHFWQQP-RH KKMSSGGAAA P--AFSKKLQ QQHVVVGGGL YGGGSSHHYS SPGGEIKLLD DDYWQQP-RH KKMSSGGAAA P--AFRTTLQ QQHVVVGGGL YGGGRRHHYD DPGGELKTTD DDFWQQP-RR NNMEEGGSSS P--HIKKKPA AAHVVVGGGL YGGGNNSHFE EDKKKYLTTD DDFWQQP-RR NNMEEGGSSS P--HIKKKPA AAHVVVGGGL YGGGNNSHFE EDKKKHLTTD ---------- ---LLGGGGG P--TVCRRLK KKCQQQPPPL VIIIKKCRY- ---------- DDYWQQP-HF NNMEEGGAAA P--LFRRRPT TTDCCCTTTQ YGGGCCRNYR RQRRELFTTD DDFWQQP-YF DDMEEGGAAA P--KWRRRNV VVDLLLSSSQ YGGGCCRNYK KSQQTLYTTD SSNHNNG--R EESRRDDEEE P--MAFEESF FFLKKKPPPL KPPPQQHAVL L--------- DDIRLLI-RK NNMSSTTGGG WNNMMDFFLQ QQDAAAKKKR FGGGNNTVWD DHRRQPKVVN DDVRLLP-RK NNLSSTTGGG WNNMMDFFLA AADPPPKKKH FGGGNNTVWD DHKKQPKVVD GEERMA---E LPPLHHPTTK KGFIMMSKSW LWWWY--GKW WWWWNAEEKK VVIIEIEEEG GEERMV---E VPPLHHPTTK KGFVVVNKSW LWWWY--GKW WWWWQAEERR VVIIDIQQQG GQQQMA---E VPPAHHPVVR RGFVVVDTSW TWWWR--GKF FFFFHVKKKK TTAATIEEEA GNNQMA---E VPPAHHPVVR RGFVVVDTSW TWWWR--GKF FFFFHAEEKK TTAATIEEEK GNNQMA---E IPPAHHPSSK KGFCVVDTAF TWWWQKKGTF FFFFEAKKKK TTIITIVVVA GEEQLV---E LPPAHHPTTK KGFVCCSKSW TWWWR--DKW WWWWAVRRKK VVIIEIEEEP GEEQMA---E LPPAHHPTTK KGFMCCSKSW LWWWR--GSW WWWWHLKKKK VVIIDIEEEE GEEQMV---E LPPAHHPAAR RGFVVVSESW LWWWR--GSW WWWWGIRRKK VVIIEIEEEP T--GLI---E IFFLHHPSSA AGFVCCSNYN EEEE------ ---------- --TTWSKKKV K--GLI---E IFFLHHPDDA AGFVCCSNYN EGGG------ ---------- --TTWSKKKV Q--GLI---E IFFLHHPDDA AGFVCCSTYN QGGG------ ---------- --TTWSKKKV Q--GLI---E IFFLHHPDDA AGFVCCSTFN EDDD------ ---------- --TTWSKKKV K--GLI---E IFFLHHPDDA AGFVCCSTYN EGGG------ ---------- --TTWSKKKV K--GLI---E IFFLHHPDDA AGFVCCSTYN EGGG------ ---------- --TTWSKKKV K--GLI---E IFFLHHPDDA AGFVCCSTYN EGGG------ ---------- --TTWSKKKV K--GLI---E IFFLHHPDDA AGFVCCSTYN EGGG------ ---------- --TTWSKKKV P--GHI---E IFFLHHPAAA AGFVCCSTYN EGGG------ ---------- --TTWSKKKV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- Q--QAGNNIC LSSIHHKNNI IDYDVVSSSP DAAA------ ---------- --AAVVRRRL G--GLI---E IFFLHHPDDA AGLVCCSTYE KDDD------ ---------- --KKWAKKKV G--GLI---E IFFLHHPDDA AGLVCCSSYE KDDD------ ---------- --KKWAKKKV G--GLL---E IFFLHHPAAK KGFVSSSNFT QDDD------ ---------- --SSWSLLLV G--GLL---E IFFLHHPAAK KGFVSSTNFT QDDD------ ---------- --SSWNIIIV G--GLL---E IFFLHHPSSK KGYVSSSNFN SDDD------ ---------- --TTWSIIIV G--GLL---E IFFLHHPSSK KGFVSSSNFN SDDD------ ---------- --TTWSVVVV G--GLL---E VFFLHHPSSK KGYVCCTNFT ADDD------ ---------- --SSWSVVVI PPPGAL---E VFFLHHPTTS SAFVCCGGHV EEEES----- --------TT --TTHALLLI PPPGAL---E VFFLHHPTTS SAFVCCGAHD EKKKP----- --------KK --VVQTLLLI ---------- ---------- ---------- ---------- ---------- ---------- G--GLT---E IFFLHHPRRE EGYVCCXXX- ---------- ---------- ---------- G--GIT---E IFFLHHPKKK KGFVCCNKKK SDDDD----- --------EE FFEEAKIIIG ---------- ---------- ---------- ---------- ---------- ---------- PAA------E IFFPWWSNNA AAFSTTTQYD DAAA------ ---------- ---------W PAA------E ICCAWWEAAH HCFTTTTQYD GEEE------ ---------- ---------W GG-PPLLKKK KPKAVVVPLV IDDKLLLSSL LLWGGGGGEE RRDDDDNPPF FKVLLLGVVK GG-PPLLKKK KDKMVVVPLV IDDRLVVSSL LLWGGGGGEE RRDDDDNPPH HQRLLLGVVK AADPPLLQQQ QGGAVVVPLV IDDRLVVSSC CCWGGGGGEE RRDDDDDPPH HNVLLLGVVR KKEPPLLQQQ QGGAVVVPLV IDDRLVVSSC CCWGGGGGEE RRDDDDDPPR RKKLLLGVVH AADPPLLKKK KGGACCCPLV IDDKLVVAAC CCWGGGGGEE HHDDDDDPPM MNVLLLGVVE PPDPPLLKKK KGKAVVVPLV IDDRLVVSSC CCWGGGGGDD LLDDDDDPPF FEKLLLGVVR EEDPPLLKKK KPKAVVVPLV IDDRLVVSSC CCWGGGGGEE HHDDDDDPPF FNRLLLGVVQ PPDPPLLKKK KDGAVVVPLV IDDRLVVSSC CCWGGGGGEE RRDDDDDPPF FNRHHHGVVR VVPKKGGWWW WMPEMMMPLI IDDRLFFSSN NNWLLGGGDD RRDDDDNPPQ QKRLLLGIIF VVPKKGGWWW WMPEMMMPLI IDDRLFFSSN NNWLLGGGDD RRDDDDNPPK KKRLLLGIIF VVPKKGGWWW WMPEMMMPLI IDDRLFFSSN NNWLLGGGDD RRDDDDDPPQ QRRLLLGLLF VVPKKGGWWW WMPEMMMPLI IDDHLFFSSN NNWLLGGGDD RRDDDDDPPQ QRRLLLGLLF VVPKKGGWWW WLPEMMMPLI IDDRLFFSSN NNWLLGGGDD RRDDDDDPPQ QRRLLLGLLF VVPKKGGWWW WLPEMMMPLI IDDRLFFSSN NNWLLGGGDD RRDDDDDPPQ QRRLLL---- VVPKKGGWWW WLPEMMMPLI ---------- ---------- ---------- ---------- VVPKKGGWWW WLPEMMMPLI IDDRLFFSSN NNWLLGGGDD RRDDDDDPPQ QRRLLLGLLF VVPKKGGWWW WMPEMMMPLI IDDRLFFNNN NNWLLGGGDD RRDDDDDPPK KRRLLLGIIF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLYVVKKFFF FGVSLLLSEF ADDLIFFLLS SS-------- ---------- ---------- VVPKKGGWWW WAPEMMMPLI IDDRLFFSSN NNWLLGGGDD RRDDDDDPPR RNKLLLGIIF VVPKKGGWWW WPPEMMMPLI IDDRLFFSSN NNWLLGGGDD RRDDDDDTTR RNKLLLGIIF VVKKKNNWWW WIPEMMMPLI FDDRLFFVVN NNWLLGGGDD RRNNNNDLLK KNVLLLGLLW VVEKKNNWWW WFPEMMMPLI FDDRLFFVVN NNWLLGGGDD RRNNNNDVVK KNKLLLGVVW VVKKKNNWWW WIPEMMMPLI FDDRLFFVVN NNWLLGGGDD RRNNNNDPPK KNVLLLGIIW VVKKKNNWWW WIPEMMMPLI FDDRIFFVVN NNWLLGGGDD RRNNNNDPPK KNVLLLGIIW IIKKKNNWWW WIPEMMMPLI FDDRLLLVVN NNWLLGGGDD RRNNNNDPPA AKVLLLGVVW IIPKKGGWWW WAPEMMMPLI IDDRLVVSSC CCWLLGGGDD RRDDDDDPPL LKKLLLSVVY IIPKKNNWWW WAPDMMMPLI IDDRLVVSSC CCWLLGGGDD RRDDDDDPPK KNKLLLSVVF ---------- ---------- ---------- ---------- ---------- ---------- ---QQNNGGG GEEMMMMGMM IDDRLFFSSN NNWRRGGGDD RRDDDDDRRA ANRLLLGVVF GGKDDSSGGG GVEDMMMGMI IDDRLVVNNC CCWRRGGGDD RRDDDDDPPE ENKLLLGLLF ---------- ---------- ---------- ---------- ---------- ---------- WWQAADDIII IGPADDDILP IDDQLIINNS SSFMMGGGKK RRDDDDDPPH HKFQQQYKKV WWQAADDIII IGPAKKKVLP IDDSLVVNNT TTFMMGGGKK RRDDDDDPPH HHRQQQYKKT GHHHADHPPP ---------- --------AA AHKTTAQLEI RRGRRRVVYY VVTLLLLLYS GHHHEPHPPP ---------- --------SS SAETTAQISV RRGRRRVVYY IITLLLLLYS GRRRAPHPPP ---------- --------NN NRTAAGQVEI RRGRRRVVYY WWTLLLLLYS GRRRTPHPPP ---------- --------NN NKAAAGQVEI RRGRRRVVYY WWTLLLLLYS GKKKTPHPPP ---------- --------NN NKTGGGQVEI RRGKKRVVYY WWTLLLLLYS GSSSATHPPP GG-------- --------KK KGANNGQVEI RRGRRRVVYY FFTLLLLLYG GRRRAGHPPP ---------- --------TT TAENNGQVEI RRGRRRVVYY FFTLLLLLYR GRRRAAHPPP ---------- --------AA AGPNNGQVEV RRGRRRVVYY FFSLLLLLYA GVVVGGSVVV QQVE--ETTC PPEEPPPLKK KKRPPGQIQL LLGKKRLLYY AATLLLLLYS GVVVGGSVVV QQVE--ETTC PPEEPPPLKK KKRPPGQIQL LLGKKRLLYY VVTLLLLLYS GVVVGGPVVV QQVE--EKKS PPEEPPPLKK KKKPPGQIQL LLGKKRLLYY VVTLLLLLYS GVVVDGPVVV QQVD--EDDS PPEEPPPLKK KKQAAGQIQL LLGKKRLLYY VVTLLLLLYS GVVVGGPVVV QQVE--EKKS PPEEPPPLKK KKRAAGQIQL LLGKKRLLYY IITLLLLLYS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GVVVGGPVVV QQVE--EKKS PPEEPPPLKK KKRAAGQIQL LLGKKRLLYY IITLLLLLYS GVVVGGPVVV QQVE--EKKS PPEEPPPLKK KKRPPGQIQL LLGKKRIIYY VVTLLLLLYS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GLLLGGPVVV TTVE--DEEC PPDDPPPVKK KKKPPGQIQL LLGKKRLLYY VVTLLLLLYS GQQQGGPVVV TTVE--EEEC PPDDPPPVKK KKIPPGQIQL LLGKKRIIYY VVTLLLLLYS GQQQGSPVVV AAAG--GTTW SSDDVVVPQQ QQKRRGQIQL LLGKKRLLYY VVTLLLLLFS GQQQGSPVVV VVAK--GTTW SSDDVVVPQQ QKKRRGQIQL LLGKKRLLYY VVTLLLLLFS GQQQGSPVVV KKAG--GSSF FFDDVVVPKK KKSRRGQIQL LLGKKRLLYY AATLLLLLFS GQQQGSPVVV KKAG--GTTF FFEEVVVPKK KKSRRGQIQL LLGKKRLLYY AATLLLLLFS GQQQGSEVVV VVYT--DEEE YYSSVVVPKK KHRRRGQIQL LLGKKRIIYY VVTLLLLLFS GHHHESNVVV KKVE--K--- IIEEAAALKK KRKEEGQLQL LLGKKRLLYY VVTLLLLLYK GHHHETTVVV KKVE--H--- IIPPAAALKK KRQEEGQLQL LLGKKRLLYY VVSLLLLLYK ---------- ---------- ---------- -----GAIQL VVGKKRLLYY VVTFFFFFYS GQQQDAPRRR RRVN--EKKE PPEEPPPVKK KRRLLGQLQL LLGRRRLLYY VVSLLLLLFS GCCCDLPNNN VVIKEEEKKE PPPPAAARKK KRREEGQLQL LLGKKRLLYY VVSLLLLLYS ---------- ---------- ---------- ---------- ---------- ---------- DNNN------ ---------- ---------- -------VSQ WWGKKRVVYY FFSLLLLLLA GNNN------ ---------- ---------- -------VSS WWGQQRLLYY YYTLLLLLLA TTWWWWQQFF YGGGGGWMKK NAA--PPSGG GLFFGGE--A RHQQSSGDAS DDDDYCP--- SSWWWWQQFF YGGGGGWMKK NVV--PPEGG GLFFGGR--A RHQQWWGDAT DDDDFCP--- TTWWWWQQFF YAAAAAAQLL HAA--PPDGG GLYFPPDG-Y RHQQEEGDCT DDDDFCPSKK TTWWWWQQFF YGGGGGVEMM NVV--GGNGG GLYFPPDG-Y RHQQEEGDCT DDDDFCPS-- TTWWWWQQFF YAAAAAAMMM NVV--EENGG GLFFPPAG-Y RHQQEEGDCT DDDDFCPS-- AAVVVVQQFF YGGGGGWMKK DAA--PPNGG GIFWPPKG-H RHQQQQGDCS DDDDYCP--- AAWWWWQQFF YGGGGGWMKK DVV--PPDGG GMFFGGE--Q RHQQQQGDAS DDDDYCP--- SSWWWWQQFF YGGGGGWIKK EAA--PPGGG GLFVGGDG-L RHQQEEGDSS DDDDYCPS-- DDWWWWQQFF YRRRRREGVV LQQVTVVNGG GLFFGGKEPA LHEEPPGDCS DDDDWI---- AAWWWWQQFF YRRRRREGVV LQQVTAANGG GLFFGGKEPA LHEEPPGDCS DDDDWI---- AAWWWWQQFF YRRRRREGVV LQQVTVVKGG GLFFGGKEPA LHEEPPGDCS DDDDWL---- AAWWWWQQFF YRRRRREGVV LQQVTVVKGG GLFFGGKEPA LHEEPPGDCS DDDDWL---- AAWWWWQQFF YRRRRREGVV LQQVTVVKGG GLFFGGKEPA LHEEPPGDCS DDDDWI---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAWWWWQQFF YRRRRREGVV LQQVTVVKGG GLFFGGKEPA LHEEPPGDCS DDDDWI---- DDWWWWQQFF YRRRRREGVV LQQVTVVKGG GLFFGGKEPA LHEEPPGDCS DDDDWL---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKWWWWQQFF YKKKKKEGVV LQQVTEEKGG GLFFGGKEPV LHEEPPGDCS DDDDWV---- IIWWWWQQFF YKKKKKEGVV LQQVTKKKGG GLFFGGKEPV LHEEPPGDCS DDDDWI---- AAWWWWQQFF YEEEEEKGHH LQQVTEEKGG GLFFGGAEPA LHEEPPGDCS DDDDWI---- AAWWWWQQFF YEEEEEQGHH LQQVTEENGG GLFFGGAEPS LHEEPPGDCS DDDDWI---- AAWWWWQQFF YDDDDDKGHH IQQVTEEKGG GLFFGGDEPA LHEEPPGDCS DDDDWI---- AAWWWWSSFF YEEEEEKGHH IQQGTEEKGG GLFFGGDEPS LHEEPPGDCS DDDDWI---- RRWWWWQQFF YKKKKKKGHH LQQVTEEKGG GLFFGGAEPS LHEEPPGDCS DDDDWI---- KKWWWWQQFF YKKKKKSGTT VQQIPEESGG KMFFGGKIEY LHEEPPGDCS DDDDWI---- KKWWWWQQFF YRRRRRSGTT LQQVPIITGG HMFFGGKVPY LHEEPPGDCS DDDDWI---- TTWWWWQQFF YKKKKKEGVV LQQVTEEKGG GLFFGGKEPC LHDDPPGDSS DDDDLA---- PPWWWWQQFF YAAAAAAGTT VQQIVEENGG GMFFGGGEPG LHEE------ ---------- PPWWWWQQFF YSSSSSQGHH VLLVTVVNGG GIFFAANEPS LHEEPPGDCS DDDDWLND-- ---------- ---------- ---------- ---------- ---------- ---------- NNWWWW---- -KKKKKKGDD AQQKYNNWDD GKFFYYELG- RHIIGGSALS SSSS------ NNWWWW---- -KKKKKKGDD EQQKYYYWDD GKFFYYAEK- RHQQGGRALA GGGGAGGNLL ------- ------- RRR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- VVVARRE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNNNKKEETR TVPPTGGTAA AADMSLPTTA QLLLSLLLTT PGGPRRKAYY QWSIIVVLLS gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- --------MM AALLLNNRRP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSPPRRSSSS GGRKTRRSVP PLLVEISSVV VVAQVVPPPQ QAAVQQAHHH HLLPGGKKHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---ERRAAEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMM MLLKEEEEPP ---------- ---------- ---------- ---------- ------LKKK KSSGCCLLGG ---------- ---------- ---------- ---------- ---------- ---------- TTPPHHPPPP AAPASPPPHP PVVPLTRLRR RRPRTINNNP PPRLPPPPPP PAAHSSLLVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMRRREEFF ---------- ---------- ---------- ---------- ---------- -MMRFFIIVV ---------- -------AAV VKKKKDFPSS PKMAAMMKAP PPPPEEEDLV ALYTTTGGIN ---------- ---------A AKKKKDFPTT PRDAAMMRAP PPPPEEEDIV ALYVVVGGVN ---------- ---------M MRRRRDFASS PELAAMMQAP PPAAEEEEFT LLSPPPDS-- ---------- ---------M MRRRRDFASS PKLAAMMEAP PPAAEEENFT LLSPPPDS-- ---------- ---------M MRRRRDFPSS AKLAAMMEGP PPVVEEEKLT LLSPPPDS-- ---------- ---------A AKKKKDFPSS PRLAAAAKAP PPPPEEETIV AFDPPPEK-- ---------- ---------V VRRRRDFPSS PRMAAVVKAP PPAAEEEKLV VLNPPPMNG- ---------- ---------A ARRRRDFPSS PKMAAMMQAP PPRREEERLV ALDPPPGE-- ---------- ----MAAKKT T----GYTPP LEAMMKK-GP PPRREEEEIL PIYRRRNGTE ---------- ---------- ---------- -----MM-GP PPRREEEEIL PIYRRRNGIE GLAPARGGGL LP--HSSQQG G----GYSPP LEAMMKK-GP PPRREEEEIL PIYGGGNGIE ---------- ---------- ---------- ---MMKK-GP PPRREEEEIL PIYRRRNGIE ---------- ----MAAKKG G----GYTPP LEAMMKK-GP PPRREEEEIL PIYRRRNGTE GLSVAQPPPM MPAATAAKKG G----GYTPP LEAMMKK-GP PPRREEEEIL PIYRRRNGTE ---------- ----MAAKKG G----GYTPP LEAMMKK-G- ---------- --------TE ---------- ----MAAKKG G----GYTPP LEAMMKK-GP PPRREEEEIL PIYRRRNGTE GQWFLSGGGQ QWEETAAKKG G----GYTPP QEAMMKK-GP PPRREEEEIL PIYRRRNGTE FNELHTYYYC CLFFSPPKKG G----GYTPP LEAMMKK-GP PPRREEEEIL PIYRRRNGTE ---------- ----MAAKKG G----GYTPP LEAMMKK-GP PPRREEEEIL PIYRRRNGTE LMGAAAVVVE EAAANGGTTC CAAAAGYTPP LEAMMEEKGP PPRREEEKLV TVYNNNGGIN ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMKKG G----GYSPP LDAMMKK-GP PPRREEEEIL PIYRRRSGIN -MTVLDHHHG GVEEKSSVVG GKKKKGYSPP IESMMSS-GP PPRREEESLV TVYAAAGGIE -MTVLQHHHA AVEEVNNQQG GKKKKGYSPP LEAMMSS-GP PPRREEETLV TVYAAAGGIE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M MVVVVGYTPP LAAMMSS-GP PPSSEEEKLV TVYTTTGGID ---------- -AAANGGAAC CAAAAGYTPP LEAMMEEKGP PPRREEEKLV TVYNNNGGIN ---------- -MPPCGGKKH H----GYSPP ADAIIKK-GP PPRREEEEVV TP-----AAD ---------- -M--CPPKKH H----GYSPP ADAIIKK-GP PPRREEEEVV TP-----ARD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------SSS SKKKKGYTPP LDAVVRRNGP PPVVEEEKLV VVQPPPNDEE ---------- ---------- ---------- ---MMRRSGP PPRREEEKLT VVQPPPNDEP ---------- ---------- -----MLT-- -DILLIISLD DDDDRRRFLS NLHGGGDRQY G-----AAAL LA--LAAGGP PAAAAATQSS PYMPPKKITG GGQQEEEEFV WLGVVVEMGD SMFALRAAAL LSLLLAAAAP PVVVVATASS PYMKKKKITG GGQQEEEDYV WLGAAAEVGD NRAFIIIAVD VNNKKKKSEY YKKVVHHHHH KVVELLLNDF WWNNACSSSA LC--P--KPP NAPFLLLAVD VDDKKKKSPY YKKIIYYYYY KLLDLLLGDF WWNNACSSSA YC--P--KPP -RPALLLAVD VKKGGGGSSY YKKVVHHHHH TVVTMMMGDF WWNNACSSSS LS--PGGHAA -KPALLLAVD VKKGGGGSPY YQQVVHHHHH TVVTMMMGDF WWNNACSSSA LS--PGGHAA -KPGLLLAVD VDDTTTTSEF FQQVVHHHHH QLLIMMMGDF WWNNACSSSA LS--PGGHAA -QPAIIIAVD VDDAAAASPY YSSVVGGGGG QVVAMMMGDF WWNNACSSSC LC--PPPHPP -KPAMMMCVD VDDQQQQSSF FQQVVGGGGG VTTDMMMGGF WWNNACSSSM LC--PPPHPP -RPALLLGVD LDDDDDDSGY YQQVVGGGGG RVVEMMMADF WWNNACAAAA LC--PPPHPP EAPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMKDS WWNNTCSSSC -----GGDSS EAPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMKDS WWNNTCSSSC -----GGDSS EAPYLLLATD IDDKKKKSPY YQQIIHHHHH RLLPMMMRDS WWNNACSSSC -----GGDSS EAPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMKDS WWNNTCSSSC -----GGDII EAPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMKDS WWNNTCSSSC -----GGDSS EAPYLLLATD VDDKKKKSPY YQQIIEEEEE ---------- ---------- ---------- EAPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMKDS WWNNTCSSSC -----GGDSS EAPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMKDS WWNNTCSSSC -----GGDSS EAPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMKDS WWNNTCSSSC -----GGDSS EAPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMKDS WWNNTCSSSC -----GGDSS EAPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMKDS WWNNTCSSSC -----GGDSS NKLYLLLATD LDDSSSSSPY YQQIIHHHHH RLLPVVVGDS WWNNSCSSSC -----GGDPP ---------- ---------- ---------- ----MMMNDS WWNNTCSSSC -----GGDAA NKPYLLLATD VDDKKKKSPY YQQIIHHHHH RLLPMMMNDS WWNNTCSSSC -----GGDSS EKPYLLLATD VDDSSSSSPY YKKIIHHHHH RLLPVVVGDT WWNNSCSSSC -----GGDPP EKPYLLLATD LDDNNNNSPY YKKIIHHHHH RLLPVVVGDT WWNNSCSSSC -----GGDPP ---------- ---------- ---------- ----MMMGDS WWNNSCSSSC -----GGDAA DKPYLLLATD VDDSSSSSPY YSSIIHHHHH RLLPMMMGDS WWNNSCSSSC -----GGDAA NKPYLLLGTD VDDNNNNSPY YQQIIHHHHH RLLPVVVGDS WWNNACSSSC -----GGDPP DGPAIIIFTD VNNEEEESDF FQQIISSSSS RVVDVVVGDT WWNNACSSSC -----DDKPP DGPAIIIFTN VNNEEEESEF FQQIISSSSS RVVDVVVGDT WWNNACSSSC -----DDKPP ---------- ---------- ---------- ---------- ---------- ---------- EHGYLLLATD VDDAAAASPY YQQIIHHHHH RTTYTTTHNS WWNNTCSSSC HFVVPGGKEE PHGYLLLSTD VDDEEEESPY YQQVVHHHHH RTTFTTTGDS WWNNACSSSC YYVVDSSKTT YDIDRRRKNR MVVQQQQVFG GSSLLKKKKK DGGPVVVEDS PPTTPRLLLK -----GGKRR DEQKLLLVTD LRRGGGGSAR RQQIINNNNN SVVSVVVRNG FFSSA----- ---------- DEQKLLLVTD ANNKKKKSPY YKKVVNNNNN TLLSVVVRNS FFTTD----- ---------- NEERRLLIIV GRRRSRIIDD DTKPPPRKII KKVIEEEEEE KKVGSRRLLH HVCDAIIIIA FEERRLLIIV ARRRSRIVDD DTKPKKRAVA KKIVEEEEVV VVRGTKKYYH HVCDAIIIIA FEERRLLIII GRRRSRVIDD DTKPPPTRIH KKIIEEDDEE LLKGSRRPPH HVCEGIIVVT FEERRLLIII GRRRSRIIDD DTKPPPTKIH KKIIEEEEEE FFKGSRRPPH HICDGIIVVT FEERRLLIII GRRRSRIVDD DVK-PPLKIH KKIIEEEEEE FFKGSRRPPH HICEGIIVVT HEERRLLVVV GRRRSRILDD DTKPPPLFLA KKVIEEEETT AARGSRRPPH HVCGGIIVVA HEERRLLVVV DRRRSHILDD DTKPPPTKVV KKVIDDNNEE AARGARRPPH HVCDGIIIIA HEERRLLIIV GRRRSRIVDD DTKPPPRRIV KKVIEEEEEE HHRGSRRPPH HICDGVVVVA TSSRNLLIIL GMMMSRVVDD DVGSPPRKLH KKVIEESSEE QQKNSNNTTH HSCSGEEMMN TSSRDLLIIL SIIISRVVDD DVGSPPRKLH KKVIEENNEE HHKNGNNLLH HSCSGEEMMS TSSRTLLMML CMMMSRVVDD DVGSPPRKLH KKVIEEEEDD HHKGGYYVVH HSCSGEEMMS TAARTLLVVL AIIISRVVDD DVGTPPRKLH KKVIEEKKDD HHKNGFFFFH HSCSGEEMMS TSSRTLLVVL SIIISRVVDD DVGSPPRKLH KKVIEEEEDD HHKEAFFLLH HSCSGEEMMS ---------- ---------- ---------- ------KKDD HHKEAFFLLH HSCSGEEMMS TSSRTLLVVL SIIISRVVDD DVGSPPRKLH KKVIEEKKDD HHKEAFFLLH HSCSGEEMMS TSSRTLLVVL SIIISRVVDD DVGSPPRKLH KKVIEEKKDD HHKEAFFLLH HSCSGEEMMS TSSRNLLVVL SIIISRVVDD DVGTPPRKLH KKVIEEKKDD HHKGGTTPPH HSCTGEEMMS TSSRTLLVVL S--------- ---------- ---------- ---------- ---------- TSSRTLLVVL SIIISRVVDD DVGSPPRKLH KKVIEEKKDD HHKEAFFLLH HSCSGEEMMS SKKRRLLIIL SLLLSRVVDD DTATPPRSLH KKVVEEEEDD AANGGFFPPH HSCSGDDMMS SVVRNLLIIL CIIISRVVDD DVGTPPRRIH KKTVEEYYEE FFKGANNLLH HSCCGEEMMS SVVRNLLIIL CIIISRVVDD DVGSPPRRIH KKTVEEYYEE FFKGANNPPH HSCCGEEMMS SEERRLLIIA SVVVSRVIDD DTKTPPRSLH KKVVDDAADD IIKGAYYPPH HSCSGEEMMS SQQRRLLIIV GVVVSRVIDD DTKTPPRSLH KKVVEEEEDD SSKGAYYPPH HSCSGEEMMS SDDRRLLVVL SIIISRAIDD DTKEPPRSLY KKYVDDKKEE AAKGAYYPPH HACSGEELLS SDDRRLLVVL SIIISRAIDD DTKEPPRSLY KKYVDDKKEE AAKGAFFPPH HAC-GEELLS SSSRRLLIIL SLLLSRVVDD DTLKPPRALH KKVVEEEEDD AAKGGFFPPH HSCSGEEMMS TKKRSLLIIV CNNNSRIINN NVEN--RYLE HHTIEESSKK HHL-SFFPPH HSCDGNNMMS TKKRSLLIIV CNNNSRVINN NVEN--RYLQ HHTIEESSKK HHL-SFFPPH HSCDGNNMMS -----MMVVP KSSSSVKVFF FVGG------ ---------- ---------- ---------- VTTRDLLVVL CNNNSRVIDD DTGTPPRKLA KKVIEE--DD LLGDTAAPPH HTCNGNNMMS VKKRDLLVVL SNNNSFILDD DVVTPPREIV KKTIDD--DD LLSNTAAPPH HTCNGNNMMS VGGGPMMLLQ SDDDGRVTTT TSLYAAWQFY PP------DD IIFVAIISSH HAYNTAAKKD -DDRRFFWWT GDDDTRIFDD DVHSPPSKLH KKTIDD--FF KKSGVGGPPH HFAGSMMIIG -DDRRLLWWA GDDDTKVFDD DVHSPPAVLS KKTITT--FF EESGVGGPPH HLAGRMMIIG AGGGEGEGPG GMMLDDDDHS LLGEIDRGQY ---------- --------LA AADFWN---- AGGGPGEGPG GLLLDDDDHT IIGEVYRGQY ---------- --------FA AADFWN---- TGGGAGDGAP PIIMDDDDCT LLGEIDRGQD ---------- --------KH HHDFWN---- TGGGGGNGPP PIIMDDDDCT LLGEIDRGQT ---------- --------LH HHDFWN---- TGGGGGDGPP PIILDDDDCT LLGEMDRGQT ---------- --------KH HHDFWN---- AGGGAGKGPG GMMLDDDDAS LLGEVERGQY ---------- --------FA AADGWH---- AGGGPGEGPG GIILDDDDHN LLGEIDRGQY ---------- --------LH HHDFWH---- AGGGPGDGPG GVVMDDDDHS LLGEVERGQQ ---------- --------LA AADFWH---- NLLLDQNGKG GLLLDDDDGT KKGEKPGGSP ---------- --------MG GGDFYQ---- SLLLDQNGKG GLLLDDDDGT KKGEKPGGAP ---------- --------MG GGDFYQ---- SLLLDKNGKG GLLLDDDDGT KKGEQPGGAP ---------- --------MG GGDFYQ---- SLLLDENGKG GLLLDDDDGT KKGEQPGGAP ---------- --------LG GGDFYQ---- SLLLDKNGKG GLLLDDDDGT KKGERPGGAP ---------- --------SG GGDFYQ---- SLLLDKNGKG GLLLDDDDGT KKGERPGGAP ---------- --------LG GGDFYQ---- SLLLDKNGKG GLLLDDDDGT KKGERPGGAP ---------- --------LG GGDFYQ---- SLLLDKNGKG GLLLDDDDGT KKGERPGGAP ---------- --------LG GGDFYQ---- SLLLDKNGKG GLLLDDDDGT KKGERPGGAP ---------- --------MG GGDFYQ---- ---------- ---------- ---------- ---------- ---------- ---------- SLLLDKNGKD DVVLLLLLPR SSG------- ---------- ---------- ---------- SLLLDENAAG GLLLLLLLDE KKGSNRLFIS ---------- --------KE EETHYEYYYY SIIIDYNGKG GLLLDDDDGT KKGEAEGEAP ---------- --------FG GGDFYQ---- SLLLDCNGKG GLLLDDDDGT KKGEVEGEAQ ---------- --------FG GGDFYQ---- SLLLDDNAEG GLLLLLLLDD KKGEKPGHPL ---------- --------FG GGDFYQ---- SIIIDDNAEG GLLLLLLLDE KKGEKPGHPL ---------- --------FG GGDFYQ---- SLLLDENAKG GLLLLLLLDD KKNEKPGHPL ---------- --------FG GGDFYQ---- SLLLDENAKG GLLLLLLLDD KKNEKPDIPL ---------- --------YG GGHFYQ---- SLLLDENAAG GLLLLLLLDE KKGEKPGHPL ---------- --------FG GGDYYQ---- SLLLENTPSG GLLLDDDDGT KKGPADEKVP ---------- --------FN NNDFYQ---- SLLLEDSPSG GLLLDDDDGT KKGPADGKVP ---------- --------FN NNDFYQ---- ---------- ---------- ---------- ---------- ---------- ---------- SMMMDENAKG GVVEFFFFDN VVGSRGDRAL ---------- --------CG GGDYYQ---- SMMMDEYAKG GIILFFFFDD IIGTKGDKAL ---------- --------CG GGDFYQ---- DVVVELVPVL LQQTSSSSKE SSAEASQFEI ---------- --------LQ QQSNNN---- GSSSDDGGRT TEEYNNNNDG AATMPTADMQ GGGAAAVGDA VVVVADDGYG GGDIAL---- GSSSNDGGRT TEEYTTTTNG AATIPTDGLR GGGAKKTG-K YYYYADDGYD DDDVAL---- PVVVVVSVPN --IIIEEDKK LLE-YRFDLR RRRKRRRKKI HHHTGGEEEN NRRML----- PVVIIITVPR --FFFEEESS LLEGYKVDLA AAAKRRRRRL YYYDGGQEEH HRRML----- PYYVVVSLPP --FFFEENVV PPENYRFDLR RRRARRRRRV QQQDGGAQQH HQQML----- PYYVVVTLPP --FFFEENVV PPENYRFDLR RRRARRRRRV QQQDGGANNH HQQML----- PYYVVVSLPP --FFFEENVV PPENYKFKLR RRRDRRRKKV QQQDGGANNH HQQML----- GTTVVVTTPD --VVVEEDVV PPDAYRFDLT TTTRRRRRRL QQQDGGDEEH HQQLF----- GTTLLLTTPR --VVVEESLL GGDGYRVDLY YYYRRRRRRL QQQDGGAEEY YQQML----- GTTVVVTTPN --IIIEEGDD PPQKYRIDLR RRRRRRRRRL QQQDGGEEEH HQQML----- RVVVVVSAPN --FFFKKDPP AAHGYRVDWQ QQQRHHHEEI QQQQTT---D DGGLP----- RIIVVVSAPN --FFFKKDPP AAHGYHVDWQ QQQRHHHEEI QQQQKK---D DGGLP----- RVVIIISAPN --FFFRRDPP AADGYHVDWQ QQQRHHHEEI QQQTQQ---D DGGLP----- RVVIIISAPN --LLLRRDPP AADGYHVDWQ QQQRRRREEV QQQPQQ---D DGGLP----- RVVIIISAPN --LLLRRDPP AADGYHVDWQ QQQHHHHEEV QQQSKK---D DGGLP----- RVVIIISAPN --LLLRRDPP AADGYHVDWQ QQQRHHHEEV QQQSKK---D DGGLP----- RVVIIISAPN --LLLRRDPP AADGYHVDWQ QQQRHHHEEV QQQSKK---D DGGLP----- RVVIIISAPN --LLLRRDPP AADGYHVDWQ QQQRHHHEEV QQQSKK---D DGGLP----- RVVIIISAPN --VVVQQNPP AADGYHVDWQ QQQRHHHEEV QQQLPP---D DGGHP----- ---------- ---------- ---------- ---------- ---------- ---------- -------HSN --RRRLLTDD YYPSVI---- ---------- ---------- ---------- ALLWWWSCSL --YYYTTTLL MMCSVILNYI IIIMRRRVVD EEEPQQ---D DQQAANNPPI RVVIIISAPK --FFFAALMM EEEGYSVDWT TTTEHHHRRI QQQDGGE--D DGGLP----- RVVIIISAPK --FFFAALMM EEDGYSVDWT TTTEHHHRRV QQQDGGK--D DGGLP----- RTTIIISAPT --FFFTTKLL QQHGYHCQLA AAARGGGEER QQQDGGN--T TGGLP----- RTTIIISAPK --FFFLLQLL QQHGYHVSWP PPPGGGGEEK QQQDGGD--K KGGLP----- RTTIIISAPK --FFFSSKLL QQHGYHVSWP PPPGGGGEEK QQQDGGE--T TGGLP----- RTTIIISAPK --FFFSSKLL QQHGYHVSWP PPPGGGGEEK QQQDGGP--T TGGLP----- RTTIIISAPA --FFFRRTLL QQHGYHVDWP PPPGGGGEEK QQQDGGS--T TGGLP----- RVVIIISSPN --IIIKKKPP AAHGYSIEWD DDDSKKKKKL QQQDPPQPPL LGGAP----- RIIIIISSPN --IIIKKKPP AAHGYSIEWD DDDTKKKKKL QQQDPPMPPR RGGAP----- ------SGPV --VVVCCRLL KKCPVCV--- ---------- ---------- ---------- HVVVVVAAPK --FFFRRRPP TTDTYRFRWQ QQQERRREEF QQQDGGD--D DGGLP----- YVVVVVSAPN --WWWRRRNN VVDSYRFKWS SSSTQQQTTY QQQDGGS--D DGGIP----- -KKEEESEPI --AAAFFESS FFLPKHEL-- ---------- ---------- ---------- RVVLLLTGWS NYMMMDDFLL QQDKFTQDLH HHHTRRRQQK KKKNPPGAAP P--------- RLLVVVTGWN NYMMMDDFLL AADKFTTDLH HHHTKKKQQK KKKDPPGAAP P--------- ---LPHPPPT KLMGGFNNMV KKDDLLLSSS SSILWF--DG AEEKKVVIIP PAAAPLEEG- ---VPHPPPT KLMGGFNNVV KKDDLLLSSS SSILWF--DG AEERRVVIIE EAAAPFEEG- ---VPHPPPV REYGGFGGVV TTNNLLLEEG SSITWW--GG VKKKKTTAIP PAAAPATTAD ---VPHPPPV REYGGFGGVV TTNNLLLEEA SSITWW--GG AEEKKTTAIP PPPPPAPPKE ---IPHPPPS KDYGGFGGVV TTNNLLLQQG AAITWWKKDG AKKKKTTIID DPPPPADDAD ---LPHPPPT KAYGGFNNCV KKDDLLLSSS SSITWY--KD VRRKKVVIIP PAAAAADDPD ---LPHPPPT KAYGGFNNCV KKDDLLLSSA SSILWY--NG LKKKKVVIIP PAAAPASSED ---LPHPPPA RTYGGFGGVV EEDDLLLSSA SSVLWH--NG IRRKKVVIIP PAAAPAEEPD LLLIFHPPPS ATQGGFGGCA NNIIQQQRRF YYKEEG---- -------TSV VEEEVIQQVP LLLIFHPPPD ATQGGFGGCA NNIIQQQRRF YYKEGG---- -------TSV VEEEVIQQVP LLLIFHPPPD AAQGGFGGCA TTIIQQQRRF YYKQGG---- -------TSV VEEEVIQQVP LLLIFHPPPD AAQGGFGGCA TTIIQQQRRF FFKEDG---- -------TSA AQQQVIQQVP LLLIFHPPPD AAQGGFGGCA TTIIQQQRRF YYKEGG---- -------TSV VEEEVIQQVP LLLIFHPPPD AAQGGFGGCA TTIIQQQRRF YYKEGG---- -------TSV VEEEVIQQVP LLLIFHPPPD AAQGGFGGCA TTIIQQQRRF YYKEGG---- -------TSV VEEEVIQQVP LLLIFHPPPD AAQGGFGGCA TTIIQQQRRF YYKEGG---- -------TSV VEEEVIQQVP LLLIFHPPPA ASQGGFGGCA TTIIQQQRRF YYKEGG---- -------TSV VEEEVIEEVP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLLLSHKKKN INQDDYVVVE SSGGRRRGGG SSDDAY---- -------AVL LKKKKLDDLY LLLIFHPPPD AAQGGLGGCA TTVVFFFRRF YYKKDG---- -------KAA AEEEVIKKVP LLLIFHPPPD ADQGGLGGCA SSIIFFFRRF YYKKDG---- -------KAA AEEEVIQQVP LLLIFHPPPA KDTGGFGGSA NNMMIIIRRF FFKQDG---- -------SSH HEEEAIPPVK LLLIFHPPPA KDTGGFGGSA NNMMIIIRRF FFKQDG---- -------SNH HEEEVISSVE LLLIFHPPPS KDTGGYGGSA NNMMIIIRRF FFKSDD---- -------TSY YEEEVISSVK LLLIFHPPPS KDTGGFGGSA NNMMIIIRRF FFKSDE---- -------TSH HEEEVISSVK LLLVFHPPPS KDTGGYGGCA NNMMVVVRRF FFKADG---- -------SSH HEEEAISSIK LLLVFHPPPT SEHAAFGGCA GGIIFFFRRI HHPEEN---- ---TT--TAA ATTTVAFFIP LLLVFHPPPT SEHAAFGGCA AAIIFFFRRI HHPEKN---- ---KK--VTA ASSSVATTIP ---------- ---------- ---------- ---------- ---------- ---------- LLLIFHPPPR ENQGGYGGCA XXXXXXXXXX XX-------- ---------- ---------- LLLIFHPPPK KAEGGFGGCA KKVVFFFHHF KKKSDS---- ---EEFFEKK KVVVDIPPGK ---------- ---------- ---------- ---------- ---------- ---------- LLLIFWSSSN ANYAAFTTTA QQLLWWWLLI YYEDAG---- ---------- ------EEWQ LLLICWEEEA HNYCCFSSTA QQLLWWWLLI YYEGEG---- ---------- ------EEWQ -LEEIIPPPP PKPPVVTTTD DDIISLLDDD KFFLYYYYLW GVVRQQDISN NPFPGGKVVK -LPPVVDDDD DKPPVVTTTD DDIISLLDDD RFFLYYYYLW GLLRQQDITN NPHPGGRVVK DLPPLLGGGG GGPPVVTTTD DDLLSLLDDD RFFLYYYYCW GMMRQQDVSD DPHPGGSVVR ELPPLLGGGG GGPPVVTTTD DDLLSMMDDD RFFLYYYYCW GMMRQQDVSD DPRPGGSVVH DLDDLLGGGG GGPPVVTTTD DDLLSLLDDD KYYLYYYYCW GMMHQQDVSD DPMPGGKVVE DLPPVVGGGG GKPPVVTTTD DDLLSMMDDD RFFLYYYYCW GLLLQQDVSD DPFPGGKVVR DLPPIIPPPP PKPPVVTTTD DDLLSVVDDD RFFLYYYYCW GLLHQQDVSD DPFPGGKVVQ DLPPLLDDDD DGPPVVTTTD DDLLSLLDDD RFFLYYYYCW GLLRQQDVSD DPFPGGSVVR PKVVKKMMMM MPPGIITTTD DDLLSLLDDD RFFLYYYYNW LIIRQQDISN NPQPGGQIIF PKVVKKMMMM MPPGIITTTD DDLLSLLDDD RFFLYYYYNW LIIRQQDISN NPKPGGQIIF PKVVKKMMMM MPPGIITTTD DDLLSLLDDD RFFLYYYYNW LLLRQQDISD DPQPGGQLLF PKVVKKMMMM MPPGIITTTD DDLLSLLDDD HFFLYYYYNW LIIRQQDVSD DPQPGGQLLF PKVVKKLLLL LPPGIITTTD DDLLSLLDDD RFFLYYYYNW LLLRQQDISD DPQPGGQLLF PKVVKKLLLL LPPGIITTTD DDLLSLLDDD RFFLYYYYNW LLLRQQDISD DPQP------ PKVVKKLLLL LPPGIITTT- ---------- ---------- ---------- ---------- PKVVKKLLLL LPPGIITTTD DDLLSLLDDD RFFLYYYYNW LLLRQQDISD DPQPGGQLLF PKVVKKMMMM MPPGIITTTD DDLLSLLDDD RFFLYYYYNW LMMRQQDISD DPKPGGQIIF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YAVVAAGGGG GVSNFFPPPP PPIIFFFSDD LLLIIIIIS- ---------- ---------- PKVVEEAAAA APPGIITTTD DDIISLLDDD RFFLYYYYNW LIIRQQDITD DPRPGGQIIF PKVVEEPPPP PPPGIITTTD DDIISLLDDD RFFLYYYYNW LIIRQQDITD DTRPGGQIIF KLVVQQIIII IPPGIITTTD DDIISLLDDD RFFLYYYYNW LIIRQQNIED DLKPGGQLLW ELVVQQFFFF FPPGIITTTD DDIISLLDDD RFFLYYYYNW LIIRQQNIED DVKPGGQVVW KLVVEEIIII IPPGIITTTD DDIISLLDDD RFFLYYYYNW LIIRQQNIED DPKPGGQIIW KLVVEEIIII IPPGIITTTD DDIISLLDDD RFFIYYYYNW LIIRQQNIED DPKPGGQIIW KLVVRRIIII IPPGIITTTD DDIISLLDDD RYYLYYYYNW LIIRQQNIED DPAPGGQVVW PKVVSSAAAA APPAIITTTD DDIISMMDDD RFFLYYYYCW LIIRQQDISD DPLVSSQVVY PKVVEEAAAA APPAIITTTD DDIISMMDDD RFFLYYYYCW LIIRQQDISD DPKPSSQVVF ---------- ---------- ---------- ---------- ---------- ---------- --GGEEEEEE EEGGMMTTTD DDIISLLDDD RYYLYYYYNW RVVRQQDISD DRAPGGQVVF KVTTGGVVVV VEGGIISSSD DDIISLLDDD RFFLYYYYCW RVVRQQDITD DPEPGGQLLF ---------- ---------- ---------- ---------- ---------- ---------- QKVVAAGGGG GPIPPPVVVD DDIIAAADDD QTTLWWWWSF MTTRLLDISD DPHPYYEKKV QKVVAAGGGG GPVPPPVVVD DDIISNNDDD SRRLWWWWTF MTTRLLDISD DPHPYYEKKT LGGIIFHRAD H--------- ---------- AHKTTGGPPP LEEIRDRRRN NNSLYYSTWD IGGLLYHREP H--------- ---------- SAETTGGPPP ISSVRDRRRN NNSLYYSSWN IGGIIARRAP H--------- ---------- NRTAAGGPPP VEEIRDRRRN NNSLYYSTWD IGGIIARRTP H--------- ---------- NKAAAAAPPP VEEIRDRRRN NNSLYYSTWD IGGIIVKKTP H--------- ---------- NKTGGYYPPP VEEIRDRRRN NNSLYYSTWD IGGIIVSRAT H--------- ---------A KGANNGGPPP VEEIRDRRRN NNSLYYGAVD IGGIIVRRAG H--------- ---------A TAENNGGPPP VEEIRDRRRN NNSLYYRAWD LGGIIVRKAA H--------- ---------- AGPNNGGPPP VEEVRDRRRN NNSLYYASWD LGGSSIVRGG SLEE-DQQEE LTTCQQPEVV KKRPPGGPPP IQQLLDRRRT TTSLYYSDWD LGGSSIVKGG SLEE-DQQEE LTTCQQPEVV KKRPPGGPPP IQQLLDRRRT TTSLYYSAWD LGGSSIVKGG PLEE-DQQEE LKKSQQPEVV KKKPPGGPPP IQQLLDRRRT TTSLYYSAWD LGGSSIVKDG PLDD-DQQEE LDDSQQPEVV KKQAAGGPPP IQQLLDRRRT TTSLYYSAWD LGGSSIVKGG PLEE-DQQEE LKKSQQPEVV KKRAAGGPPP IQQLLDRRRT TTSLYYSAWD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGGSSIVKGG PLEE-DEEEE LKKSQQPEVV KKRAAGGPPP IQQLLDRRRT TTSLYYSAWD LGGSSIVKGG PLEE-DQQEE LKKSQQPEVV KKRPPGGPPP IQQLLDRRRT TTSLYYSDWD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGGSSILRGG PLEE-DKKDD LEECQQPDIV KKKPPGGPPP IQQLLDRRRN NNSLYYSKWD LGGSSIQRGG PLEE-DKKEE LEECQQPDTV KKIPPGGPPP IQQLLDRRRS SSSLYYSIWD VGGLLIQKGS PIGG-EDDGG KTTWQQSDEI QQKRRGGPPP IQQLLDRRRN NNSLFFSAWD AGGLLIQKGS PVKK-DDDGG ETTWQQSDEI QKKRRGGPPP IQQLLDRRRN NNSLFFSAWD VGGLLLQKGS PVGG-EDDGG NSSFQQFDQI KKSRRGGPPP IQQLLDRRRN NNSLFFSAWD VGGLLLQKGS PVGG-EDDGG NTTFQQFEQI KKSRRGGPPP IQQLLDRRRN NNSLFFSAWV AGGLLLQKGS EVTT-EDDDD KEEEQQYSQV KHRRRGGPPP IQQLLDRRRN NNSLFFSRWD IGGSSVHTES NLEE-GEEKK ----PPIEYV KRKEEGGPPP LQQLLDRRRT TTSLYYKKWD IGGSSIHSET TLEE-EDDHH D---EEIPYV KRQEEGGPPP LQQLLDRRRT TTSLYYKKWD ---------- ---------- ---------- -----GGPPP IQQLVDRRRN NNSFYYSTWD LGGAAIQRDA PLNN-DPPEE LKKEAAPEFL KRRLLGGPPP LQQLLDRRRS SSSLFFSPWD LGGAAICSDL PVKKEDKKEE LKKERRPPYV KRREEGGPPP LQQLLDRRRS SSSLYYSPWD ---------- ---------- ---------- ---------- ---------- ---------- IDRQQVN--- ---------- ---------- ---------- VSSQWDRRRS SSSLLLANWD IGAQQVN--- ---------- ---------- ---------- VSSSWDRRRS SSSLLLANWD NYYPPPEGLG KKNNN---PP SGGGGLIKEE FFDDDEE--- --SVRLSGGA SSSYYPP--- NYYPPP-GLG KKNNN---PP EGGGGLLKEE FFDDDRR--- --AVRLWGGA STTFFPP--- DYYPPPDGVA LLHGG---PP DGGGGLLDDD YYEEEDD--- --AIRLEGGC STTFFPPSSV DYYPPPDGVG MMNGG---GG NGGGGLLKDD YYSSSDD--- --AIRLEGGC STTFFPPSSV EYYPPPGDRA MMNGG---EE NGGGGLLKDD FFDDDAA--- --SIRLEGGC STTFFPPSSV PYYPPPEGIG KKDGG---PP NGGGGIFPKK FFEEEKK--- --PVRLQGGC SSSYYPP--- EYYPPPDGIG KKDNN---PP DGGGGMFPNN FFDDDEE--- --VIRLQGGA SSSYYPP--- EYYPPPVGIG KKEDD---PP GGGGGLLPGG FFEEEDD--- --PIRLEGGS SSSYYPPSS- KYY---PDLR VVLVVTTTVV NGGGGLLPNN FFDDDKKPPL LPALRYPGGC SSSWW----- KYY---PNLR VVLIITTTAA NGGGGLLPNN FFDDDKKPPL LPALRYPGGC SSSWW----- KYY---PDLR VVLIITTTVV KGGGGLLPNN FFDDDKKPPL LPALRYPGGC SSSWW----- KYY---PDLR VVLIITTTVV KGGGGLLPNN FFDDDKKPPL LPALRYPGGC SSSWW----- KYY---PDLR VVLVVTTTVV KGGGGLLPNN FFDDDKKPPL LPALRYPGGC SSSWW----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KYY---PDLR VVLVVTTTVV KGGGGLLPNN FFDDDKKPPL LPALRYPGGC SSSWW----- KYY---PDLR VVLIITTTVV KGGGGLLPNN FFDDDKKPPL LPAIRYPGGC TSSWW----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KYY---PDMK VVLIITTTEE KGGGGLLPNN FFDDDKKPPG GPALRYPGGC SSSWW----- KYY---PDLK VVLIITTTKK KGGGGLLPNN FFDDDKKPPD DPAIRYPGGC TSSWW----- KYY---PGLE HHLIITTTEE KGGGGLIPNN FFDDDAAPPD DPAMRYPGGC TSSWW----- KYY---PKLE HHLIITTTEE NGGGGLIPNN FFDDDAAPPD DPAMRYPGGC TSSWW----- RYY---PELD HHIIITTTEE KGGGGLIPNN FFDDDDDPPE EPAMRYPGGC TSSWW----- VYY---PEIE HHIIITTTEE KGGGGLIPDD FFDDDDDPPD DPAMRYPGGC TSSWW----- EYYGGGQDLK HHLIITTTEE KGGGGLIPNN FFDDDAAPPE EPAMRYPGGC TSSWW----- DYY---PEHK TTVVVPPPEE SGGGGMIRDD FFDDDKKEEG GPAMRYPGGC TSSWW----- DYY---PENR TTLIIPPPII TGGGGMIKNN FFDDDKKPPG GPAMRYPGGC TSSWW----- KYY---PNVK VVLIITTTEE KGGGGLVKNN FFDDDKKPPN NPAIRFPGGS TSSLL----- KYY---PEMA TTVLLVVVEE NGGGGMLENN FFDDDGGPPY YPPMR----- ---------- KYY---PKMS HHVIITTTVV NGGGGILEDD FFDDDNNPPY YPPMRYPGGC TSSWWNNDDA ---------- ---------- ---------- ---------- ---------- ---------- ---------K DDAYYYYYNN WDDDDKLEDD FFDDDEEGGL L-AMRFGSSL YSS------- ---------K DDEFFYYYYY WDDDDKLEQQ FFDDDAAKKL L-PMRFGRRL YAAAAGGNNR ------- ------- KR----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LVQQRVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158SSAKKKKQSA ATTPRRVPGL AAAALLAAGA AAQSSLLLTT TAQLLLLPPV RRKKYQQWWW gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ----MAAAAA gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TTTSIIQQSS SSSESKGRKT VVGGGEEIIS SVKVVPPPSQ QQAWWWWHWW LLPPKHGGVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --EEAEGGTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MGG LLKKEPGGAA ---------- ---------- ---------- ---------- ---LLLLKNN SSGGLGFFTT ---------- ---------- ---------- ---------- ---------- ---------- PPPPLLNNTP PPPNPLAPAS HHRRRLLTTL LRYTINNNVP PPPCCCCPHH AAHHLVLLII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMRREFGG-- ---------- ---------- ---------- ---------- ---------- MMRRIVSSSS ---------- MIIIVVPPFR TFPPSMAAMM MMMKAAPPPA YYAACLLYYT GGTTTGGIIN ---------- -MMMAAKKLP TFPPTDAAMM MMMRAAPPPA YYAAALLYYV GGTTTGGVVN ---------- ----MMSSMP TFAASLAAMM MMMQAAPAAA YYLLLLLSSP DDFFFSS--- ---------- ----MMTTMP TFAASLAAMM MMMEAAPAAA YYLLLLLSSP DDFFFSS--- ---------- ----MMTTLP TFPPSLAAMM MMMEGGPVVA FFLLMLLSSP DDAAASS--- ---------- -MMMAATTWP SFPPSLAAAA AAAKAAPPPA YYAAMFFDDP EERRRKK--- ---------- -MMMVVTTWP TFPPSMAAVV VVVKAAPAAA YYVVRLLNNP MMAAANNGG- ---------- -MMMAASSWP TFPPSMAAMM MMMQAAPRRG YYAALLLDDP GGRRREE--- --------MA TCCCTTKK-C GYTTPAMMKK KKK-GGPRRV YYPPCIIYYR NNTTTGGTTE ---------- ---------- --------MM MMM-GGPRRV YYPPCIIYYR NNTTTGGIIE VIAGPPGAHS TCCCGGKK-C GYSSPAMMKK KKK-GGPRRV YYPPCIIYYG NNTTTGGIIE ---------- ---------- ------MMKK KKK-GGPRRI YYPPCIIYYR NNTTTGGIIE --------MA TCCCGGNN-C GYTTPAMMKK KKK-GGPRRV YYPPCIIYYR NNTTTGGTTE TQSPPPISTA TCCCGGNN-C GYTTPAMMKK KKK-GGPRRV YYPPCIIYYR NNTTTGGTTE --------MA TCCCGGNN-C GYTTPAMMKK KKK-GG---- ---------- -------TTE --------MA TCCCGGNN-C GYTTPAMMKK KKK-GGPRRV YYPPCIIYYR NNTTTGGTTE APWGWWQDTA TCCCGGDD-C GYTTPAMMKK KKK-GGPRRV YYPPCIIYYR NNTTTGGTTE TTEYLLVTSP TCCCGGNN-C GYTTPAMMKK KKK-GGPRRV YYPPCIIYYR NNTTTGGTTE --------MA TCCCGGNN-C GYTTPAMMKK KKK-GGPRRV YYPPCIIYYR NNTTTGGTTE IEGVAAAANG KCCCCCHHTK GYTTPAMMEE EEEKGGPRRV YYTTCVVYYN GGTTTGGIIN ---------- ---------- ---------- ---------- ---------- ---------- ---------M ACCCGGSS-C GYSSPAMMKK KKK-GGPRRV YYPPCIIYYR SSTTTGGIIN -ATHVVNKKS -NNNGGCCCS GYSSPSMMSS SSS-GGPRRI YYTTAVVYYA GGTTTGGIIE -GTHVVSKVN NQQQGGCCCS GYSSPAMMSS SSS-GGPRRI YYTTAVVYYA GGTTTGGIIE ---------- ---------- ---------- ---------- ---------- ---------- ---------- -RRRMMLLQG GYTTPAMMSS SSS-GGPSSI YYTTAVVYYT GGTTTGGIID ----AAAANG ACCCCCGGGT GYTTPAMMEE EEEKGGPRRL YYTTCVVYYN GGTTTGGIIN ----MMSNCG LCCCHHGG-- GYSSPAIIKK KKK-GGPRRL FFTTAPP--- --NNNAAAAD ----MMP-CP LCCCHHGG-- GYSSPAIIKK KKK-GGPRRL FFTTAPP--- --HHHAARRD ---------- ---------- ---------- ---------- ---------- ---------- ---------- MEEESSKKCC GYTTPAVVRR RRRNGGPVVL YYVVCVVQQP NNLLLDDEEE ---------- ---------- ------MMRR RRRSGGPRRL YYVVTVVQQP NNLLLDDEEP ---------- ---------- GLTT-ILLII IIISLLDDDY FFNNWLLHHG DDIIIRRQQY ---AAAGALA MLLLPPFFRF ETQQSMPPKK KKKITTGQQV YYWWTLLGGV EEGGGMMGGD SHFASSGALA LAAAPPAAGR ETAASMKKKK KKKITTGQQV YYWWTLLGGA EEGGGVVGGD RAADIAAVVD DNPPKTYYSK VVHHKVLIEE EHFFFGWNNN ALCC--NNGG GGPNNNNIEI APPDLAAVVD DDPPKTYYGK IIYYKLLIEE EHFFFGWNNN AYCC--NNAA AAPFFFFLEI RPPDLAAVID DKPPGTYYGK VVHHTVMTEE EHFFFGWNNN SLSS--LLTT TTAFFFFLEI KPPDLAAVID DKPPGTYYGQ VVHHTVMKEE EHFFFGWNNN ALSS--LLAA AAAFFFFIEI KPPDLAAVVD DDPPTKFFGQ VVHHQLMKEE EHFFFGWNNN ALSS--LLTT TTAFFFFLEI QPPDIAAVVD DDPPARYYAS VVGGQVMAEE EHFFFGWNNN CLCC--NNAA AAPHHHHMEV KPPDMCCVVD DDSSQTFFGQ VVGGVTMTEE EHFFFGWNNN MLCC--NNAA AAPHHHHVEV RPPDLGGVLD DDPPDTYYAQ VVGGRVMAEE EHFFFGWNNN ALCC--YYAA AAPHHHHVEI APPDLAATVD DDPPKQYYSQ IIHHRLMLEE EHSSSGWNNN C-------FF FFSTTTTKSI APPDLAATVD DDPPKHYYSQ IIHHRLMLEE EHSSSGWNNN C-------FF FFSTTTTKSI APPDLAATVD DDPPKQYYCQ IIHHRLMLEE EHSSSGWNNN C-------FF FFSTTTTKSM APPDLAATVD DDPPKQYYCQ IIHHRLMLEE EHSSSGWNNN C-------YY YYITTTTKAV APPDLAATVD DDPPKQYYCQ IIHHRLMLEE EHSSSGWNNN C-------FF FFSTTTTKSV APPDLAATVD DDPPKQYYCQ IIEE------ ---------- ---------- ---------- APPDLAATVD DDPPKQYYCQ IIHHRLMLEE EHSSSGWNNN C-------FF FFSTTTTKSV APPDLAATVD DDPPKQYYCQ IIHHRLMLEE EHSSSGWNNN C-------FF FFSTTTTKSV APPDLAATVD DDPPKQYYSQ IIHHRLMLEE EHSSSGWNNN C-------FF FFSTTTTKSV APPDLAATVD DDPPKQYYCQ IIHHRLMLEE EHSSSGWNNN C-------FF FFSTTTTKSV APPDLAATVD DDPPKQYYCQ IIHHRLMLEE EHSSSGWNNN C-------FF FFSTTTTKSV KLLDLAATVD DDPPSTYYSQ IIHHRLVIKK KHSSSGWNNN C-------HH HHPSSSSAKI ---------- ---------- ------MTEE EHSSSGWNNN C-------YY YYASSSSKVI KPPDLAATVD DDPPKSYYSQ IIHHRLMVEE EHSSSGWNNN C-------YY YYSSSSSKVI KPPDLAATVD DDPPSTYYSK IIHHRLVVEE EHTTTGWNNN C-------HH HHPSSSSAEI KPPDLAATVD DDPPNTYYSK IIHHRLVVEE EHTTTGWNNN C-------HH HHPSSSSAQI ---------- ---------- ------MVEE EHSSSGWNNN C-------HH HHASSSSADV KPPDLAATVD DDPPSSYYSS IIHHRLMVEE EHSSSGWNNN C-------HH HHASSSSVDV KPPDLGGTVD DDPPNTYYSQ IIHHRLVVEE EHSSSGWNNN C-------HH HHPSSSSASI GPPDIFFTVD DNPPETFFCQ IISSRVVIEE EHTTTGWNNN C-------HH HHPTTTTEKI GPPDIFFTVN NNPPETFFCQ IISSRVVIEE EHTTTGWNNN C-------HH HHPTTTTEKI ---------- ---------- ---------- ---------- ---------- ---------V HGGDLAATVD DDPPATYYCQ IIHHRTTKEE EHSSSGWNNN CHFFVV--GG GGEVVVVPTV HGGDLSSTVD DDPPETYYCQ VVHHRTTKEE EHSSSGWNNN CYYYVVEESS SSTVVVVPKV DIITRKKNPR RVGGQLGGGS LLKKDGVLKK KDSSSQPTTT K--------- --RVVVVQGL EQQDLVVTID DRPPGTRRGQ IINNSVV-EE EHGGGGFSSS ---------- --------DW EQQDLVVTVD DNPPKQYYGK VVNNTLV-EE EHSSSDFTTT ---------- --------DW VPLSSRIIII DTKNPREPPK KIIIVIEKVS GGYYYVHCCC CAAIYYYSSG NNEEEEEPPG VPLSSRIIVV DTKDKRRPPA AVAAIVEVRT GGYYYVHCCC CAAIYYYSSG GGPPPDEPPG IPLSSRIVII DTKHPTQAAR RIHHIIELKT GGYYYVHCCC CGGIYYYSSG GGAAADDAAP IPLSSRIIII DTKDPTKAAK KIHHIIEFKT GGYYYIHCCC CGGIYYYSSG GGGGGDNPPP IPISSRIIVV DVKEPLKAAK KIHHIIEFKT GGYYYIHCCC CGGIYYYSSG GGGGGDDPPP VPLSSRIILL DTKDPLKPPF FLAAVIEART GGYYYVHCCC CGGIYYYTTG NNAAAEKPPG VPISSHIILL DTKDPTQPPK KVVVVIDART GGYYYVHCCC CGGIYYYSSG SSPPPEEPPG VPISSRIIVV DTKDPREPPR RIVVVIEHRT GGYYYIHCCC CGGVYYYSSG SSPPPEDPPG LPLSSRIVVV DVGEPRAPPK KLHHVIEQKC NNVVVSHCCC CGGEVVVVVL GGDDDLNKKG LPISSRIVVV DVGEPRAPPK KLHHVIEHKC NNLLLSHCCC CGGEVVVIIL GGDDDPNKKG LPLSSRIVVV DVGDPRAPPK KLHHVIEHKC GGLLLSHCCC CGGEVVVIIL GGDDDSNKKG LPLSSRIVVV DVGEPRAPPK KLHHVIEHKC NNLLLSHCCC CGGEVVVVVL GGDDDPNKKG LPLSSRIVVV DVGEPRAPPK KLHHVIEHKC EELLLSHCCC CGGEVVVIIL GGDDDVNKKG ---------- ---------- -------HKC EELLLSHCCC CGGEVVVIIL GGDDDVNKKG LPLSSRIVVV DVGEPRAPPK KLHHVIEHKC EELLLSHCCC CGGEVVVIIL GGDDDVNKKG LPLSSRIVVV DVGEPRAPPK KLHHVIEHKC EELLLSHCCC CGGEVVVIIL GGDDDVNKKG LPFSSRIVVV DVGEPRAPPK KLHHVIEHKC GGLLLSHCCC CGGEVVVIIL GGDDDPNKKG LPL------- ---------- ---------- ---------- ---------- ---------- LPLSSRIVVV DVGEPRAPPK KLHHVIEHKC EELLLSHCCC CGGEVVVIIL GGDDDVNKKD LPLSGRVVVV DTADPRTPPS SLHHVVEANI GGLLLSHCCC CGGDIIIIIL GGDDDKNAAG LPLSSRIVVV DVGDPRAPPR RIHHTVEFKC GGLLLSHCCC CGGEIIIIII GGDDDPNKKG LPLSSRIVVV DVGDPRAPPR RIHHTVEFKC GGLLLSHCCC CGGEIIIIIL GGDDDPNKKG APLSGRIVII DTKNPRSPPS SLHHVVDIKT GGLLLSHCCC CGGELLLIIL GGDDDKNEEG VPISGRVVII DTKNPRAPPS SLHHVVESKT GGLLLSHCCC CGGEIIIIII GGDDDKNEEG LPLSGRIAII DTKNPRAPPS SLYYYVDAKT GGLLLAHCCC CGGEIIIVVL GGDDDENKKG LPLSGRIAII DTKNPRAPPS SLYYYVDAKT GGLLLAHCCC CGGEIIIVVL GGDDDENKKG LPLSGRVVVV DTLDPRAPPA ALHHVVEAKT GGLLLSHCCC CGGEIIIIIL GGDDDKNAAG VPLSDRIIII NVEE-RKIIY YLEETIEHLN --LLLSHCCC CGGNIIIIIL GGEEEATSSG VPLSDRIVII NVEE-REIIY YLQQTIEHLN --LLLSHCCC CGGNIIIIIL GGEEEASSSG PRLSGVEKVV FVG------- ---------- ---------- ---------- ---------- LPLSDRIVII DTGDPRAPPK KLAAVIELGA DDCCCTHCCC CGGNIIIIIM GGDDDANKKG LPLSDFIILL DVVDPRKPPE EIVVTIDLSH NNVVVTHCCC CGGNIIIIIM GGDDDAYKKG QLLGKRLVTT TSLSAWDKKQ QFYY---IFL VVLLLADYYY YTTALLLQQV NNEEESVVVL TGLTNRIIFF DVHDPSNPPK KLHHTIDKSG GGVVVFFAAA ASSMMMMTTS NNDDDDGRRT AGLTSKIVFF DVHDPARPPV VLSSTITESG GGVVVLYAAA ARRMLLLTTS NNNNNKGRRT LMMMLDDSPP GKIIDRDQYY ---------Y YFFFFWWNN- --PPNVLLSS EEEWAAAVVN FLLLLDDTPP GRVVYRPQYY ---------Y YFFFFWWNN- --PPSVMMTT EEEWTTTVVR FIIIMDDTVV GRIIDRPQDD ---------Y YFFFFWWNN- --PPRYMMSS EEEWAAALLP FIIIMDDTVV GRIIDRPQTT ---------Y YFFFFWWNN- --PPRYMMTT EEEWAAALLP FIIILDDTII GRMMDREQTT ---------Y YFFFFWWNN- --PPRYMMSS EEEWGGGLLP AMMMLDDSPP GRVVERPQYY ---------Y YGGGGWWHH- --GGYTLLTT EEEWGGGTTD FIIILDDNVV GRIIDRDQYY ---------Y YFFFFWWHH- --GGYTLLTT EEEWGGGTTR FVVVMDDSPP GRVVERPQQQ ---------Y YFFFFWWHH- --GGYTMMTT EEEWGGGTTN VLLLLDDTVV GTKKPGASPP ---------Y YFFFFWYQQ- --RRHVMMSS EEEWAAAAAN VLLLLDDTVV GTKKPGEAPP ---------Y YFFFFWYQQ- --RRHIMMSS EEEWAAAAAN VLLLLDDTVV GTQQPGAAPP ---------Y YFFFFWYQQ- --RRHVMMSS EEEWAAAAAN VLLLLDDTVV GTQQPGAAPP ---------Y YFFFFWYQQ- --RRHVMMSS EEEWAAAAAN VLLLLDDTVV GTRRPGAAPP ---------Y YFFFFWYQQ- --RRHVMMSS EEEWAAAAAN VLLLLDDTVV GTRRPGAAPP ---------Y YFFFFWYQQ- --RRHVMMSS EEEWAAAAAN VLLLLDDTVV GTRRPGAAPP ---------Y YFFFFWYQQ- --RRHVMMSS EEEWAAAAAN VLLLLDDTVV GTRRPGAAPP ---------Y YFFFFWYQQ- --RRHVMMSS EEEWAAAAAN VLLLLDDTVV GTRRPGSAPP ---------Y YFFFFWYQQ- --RRHVMMSS EEEWAAAAAN ---------- ---------- ---------- ---------- ---------- ---------- LVVVLLLRCC G--------- ---------- ---------- ---------- IIISAAAHHN FLLLLLLEVV GRNNRLPISS ---------R RHHHHLYEEY YYAAWLFFSS IIIQCCCCCL VLLLLDDTVV GNAAEGAAPP ---------Y YFFFFWYQQ- --RRHVMMSS EEEWGGGAAK VLLLLDDTVV GNVVEGSAQQ ---------Y YFFFFWYQQ- --RRHVMMSS EEEWGGGAAK FLLLLLLDVV GRKKPGSPLL ---------Y YFFFFWYQQ- --RRHTMMSS SSSWGGGAAT FLLLLLLEVV GRKKPGSPLL ---------Y YFFFFWYQQ- --RRHTMMSS SSSWGGGAAK FLLLLLLDII NRKKPGSPLL ---------Y YFFFFWYQQ- --RRHTMMSS SSSWGGGAAK LLLLLLLDII NRKKPDSPLL ---------Y YFFFFWYQQ- --RRHTMMSS SSSWGGGAAK FLLLLLLEVV GRKKPGSPLL ---------Y YYYYYWYQQ- --RRHTMMSS SSSWGGGAAA LLLLLDDTPP GTAADETVPP ---------Y YFFFFWYQQ- --RRRVMMSS EEEWGGGSSN LLLLLDDTPP GTAADGVVPP ---------Y YFFFFWYQQ- --RRRIMMSS EEEWGGGSSN ---------- ---------- ---------- ---------- --------SS LLLRGGGGGV FVVVEFFNLL GTRRGDKALL ---------Y YYYYYWYQQ- --HHFVMMAA EEEWGGGAAK FIIILFFDCC GTKKGDKALL ---------Y YFFFFWYQQ- --YYFVMMSS EEEWGGGAAN IQQQTSSELL AKAASQEEII ---------L LNNNNHNNN- ----RKSSSS RRRPDDDEEI VEEEYNNGVV TYPPTADMQQ GGGVDDAAAY YIIIIRALL- --RRKVMMTT SSSFTTTGGS VEEEYTTGVV THPPTDDLRR GGGI--KKAY YVVVVRALL- --RRKLLLTT SSSFTTTGGN NN--EDDGLK LLEEELKKD- --YNNIFFLL RRKKKKRIII HSSLLTLGER MMAL-----E RR--EEEGFS LLEEELKKEG GGYNNLVVLL AAKKRRHLLL YAAIIDLGER MMVL-----E PP--ENNGIV PPEEELLLAN NNYHHLFFLL RRAARRNVVV QTTIIDLGQQ MMAL-----E PP--ENNGIV PPEEELLLSN NNYHHLFFLL RRAARRNVVV QTTIIDLGNQ MMAL-----E PP--ENNGIV PPEEELLLSN NNYHHIFFLL RRDDKKNVVV QTTIIDLGNQ MMAL-----E DD--EDDGLV PPDDDLLLGA AAYRRLFFLL TTRRRRHLLL QEEIIDFGEQ LLVF-----E RR--ESSGVL GGDDDLLLAG GGYHHLVVLL YYRRRRHLLL QTTLLDLGEQ MMAL-----E NN--EGGGLD PPQQQLLLNK KKYRRLIILL RRRRRRHLLL QAALLDVGEQ MMVL-----E NN--KDDGNP AAHHHEAA-G GGYSSIVVWW QQRREEIIII QTTLLQMT-G LLIP---LLE NN--KDDGNP AAHHHEAA-G GGYSSIVVWW QQRREEIIII QTTLLQMK-G LLIP---LLE NN--RDDGNP AADDDEAA-G GGYSSLVVWW QQRREEIIII QTTLLTLQ-G LLIP---LLE NN--RDDGNP AADDDKAA-G GGYSSLVVWW QQRREEIVVV QTTLLPLQ-G LLIP---LLE NN--RDDGNP AADDDEAA-G GGYSSLVVWW QQHHEEIVVV QTTLLSLK-G LLIP---LLE NN--RDDGNP AADDDEAA-G GGYSSLVVWW QQRREEIVVV QTTLLSLK-G LLIP---LLE NN--RDDGNP AADDDEAA-G GGYSSLVVWW QQRREEIVVV QTTLLSLK-G LLIP---LLE NN--RDDGNP AADDDEAA-G GGYSSLVVWW QQRREEIVVV QTTLLSLK-G LLIP---LLE NN--QNNGNP AADDDEAA-G GGYKKLVVWW QQRREEIVVV QTTLLLMP-G HHIP---LLE ---------- ---------- ---------- ---------- ---------- ---------- NN--LTTGRD YYPPPSAA-S SSVGGT---- ---------- ---------- ---------- LL--TTTGEL MMCCCTAA-S SSVVVSLLYY IIMMVVIDDD ESSLLPLQ-Q AAGAPIILLC KK--ALLGKM EEEEEQAA-G GGYHHLVVWW TTEERRRIII QTTIIDLG-G LLIP---LLE KK--ALLGKM EEDDDQAA-G GGYHHLVVWW TTEERRLVVV QTTIIDLG-G LLIP---LLE TT--TKKGDL QQHHHADD-G GGYRRLCCLL AARREELRRR QTTLLDLG-G LLLP---LLE KK--LQQGNL QQHHHADD-G GGYRRLVVWW PPGGEEIKKK QTTLLDLG-G LLLP---LLE KK--SKKGDL QQHHHADD-G GGYSSLVVWW PPGGEEMKKK QLLIIDLG-G LLLP---LLE KK--SKKGNL QQHHHADD-G GGYSSLVVWW PPGGEEIKKK QLLIIDLG-G LLLP---LLE AA--RTTGDL QQHHHQDD-G GGYRRLVVWW PPGGEELKKK QTTLLDLG-G LLLP---LLE NN--KKKGNP AAHHHGEE-G GGYNNVIIWW DDSSKKYLLL QTTIIDLPPG AALP---LLE NN--KKKGNP AAHHHPEE-G GGYNNVIIWW DDTTKKHLLL QTTIIDLPPG AALP---LLE VV--CRRDEL KKCCCPEE-P PPVKKKVV-- ---------- ---------- ---------- KK--RRRGHP TTDDDDDDRT TTYCCLFFWW QQEEEELFFF QTTIIDLG-G LLTP---LLE NN--RRRGKN VVDDDEDDMS SSYCCLFFWW SSTTTTLYYY QTTIIDLG-G IITP---LLE II--FEESES FFLLLKTTGP PPKQQVEE-- ---------- ---------- ---------- SSNNDFFGML QQDDDEAAMK KKFNNIQQLL HHTTQQPKKK KVVFFNVPA- -------LLE NNNNDFFGML AADDDEAAMK KKFNNVTTLL HHTTQQPKKK KVVFFDVPA- -------LLE EELLLHHLLM MMGGINVVSL DLSSSIWYEE GKKWWNNAEV IIPAELEEEG GNLPILLKKP EEVVLHHLLM MMGGVNVLNT DLSSSIWYEE GKKWWQQAEV IIEAQFEEEG GPLPVLLKKD EEVVAHHEEY YYGGVGVVDT NLESSIWREE GKKFFHHVKT AIPAEATTTA AELPLLLQQG EEVVAHHEEY YYGGVGVVDT NLESSIWREE GKKFFHHAET AIPPEAPPPK KKLPLLLQQG EEIIAHHDDY YYGGCGVVDT NLQAAIFQDD GTTFFEEAKT IIDPVADDDA ADLPLLLKKG EELLAHHAAY YYGGVNVISL DLSSSIWRDD DKKWWAAVRV IIPAEADDDP PQLPVLLKKG EELLAHHAAY YYGGMNVVSL DLSSSIWRDD GSSWWHHLKV IIPAEASSSE EQLPILLKKP EELLAHHTTY YYGGVGVVSL DLSSSVWRQQ GSSWWGGIRV IIPAEAEEEP PQLPLLLKKD EEIILHHTTQ QQGGVGALSS IQRYYKN--- ---------- TSVEKIQQQV VSKKKGGWWM EEIILHHTTQ QQGGVGALSS IQRYYKN--- ---------- TSVEKIQQQV VSKKKGGWWM EEIILHHAAQ QQGGVGALSS IQRYYKN--- ---------- TSVEKIQQQV VPKKKGGWWM EEIILHHAAQ QQGGVGALSS IQRFFKN--- ---------- TSAQKIQQQV VPKKKGGWWM EEIILHHAAQ QQGGVGALSS IQRYYKN--- ---------- TSVEKIQQQV VPKKKGGWWL EEIILHHAAQ QQGGVGALSS IQRYYKN--- ---------- TSVEKIQQQV VPKKKGGWWL EEIILHHAAQ QQGGVGALSS IQRYYKN--- ---------- TSVEKIQQQV VPKKKGGWWL EEIILHHAAQ QQGGVGALSS IQRYYKN--- ---------- TSVEKIQQQV VPKKKGGWWL EEIILHHSSQ QQGGVGALSS IQRYYKN--- ---------- TSVEKIEEEV VPKKKGGWWM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CCLLIHHNNQ QQDDDVEVSF GRGSSDP--- ---------- AVLKRLDDDL LYAVAKKFFG EEIILHHAAQ QQGGVGALSS VFRYYKE--- ---------- KAAEKIKKKV VSKKEGGWWA EEIILHHDDQ QQGGVGALSS IFRYYKE--- ---------- KAAEKIQQQV VSKKEGGWWP EEIILHHDDT TTGGVGALSS MIRFFKT--- ---------- SSHELIPPPV VPLKQNNWWI EEIILHHDDT TTGGVGALTS MIRFFKT--- ---------- SNHEIISSSV VPLKQNNWWF EEIILHHDDT TTGGVGALSS MIRFFKN--- ---------- TSYEIISSSV VPLKENNWWI EEIILHHDDT TTGGVGALSS MIRFFKN--- ---------- TSHEVISSSV VPLKENNWWI EEVVLHHDDT TTGGVGALTS MVRFFKT--- ---------- SSHEVISSSI IPLKRNNWWI EEVVLHHEEH HHAAVGALGS IFRHHPVS-- ---------- TAATLAFFFI ISKKSGGWWA EEVVLHHEEH HHAAVGALGS IFRHHPDP-- ---------- VTASLATTTI ISKKENNWWA ---------- ---------- ---------- ---------- ---------- ---------- EEIILHHNNQ QQGGVGAFXX XXXXX----- ---------- ---------- ---QENNGGE EEIILHHAAE EEGGVGALNA VFHKKKKD-- ---------F EKKVIIPPPG GLVDGSSGGV ---------- ---------- ---------- ---------- ---------- ---------- EEIIPWWNNY YYAASTALTS LWLYYED--- ---------- ------EEEW WAKAADDIIG EEIIAWWNNY YYCCTSALTS LWLYYED--- ---------- ------EEEW WAKAADDIIG PPFFKVPPPT TIDISSLLLD KKKKFLLLLL YWWIEVYIIS NPPFKVTGKK LLLGGGGGIF DDFFKVPPPT TIDISSLLLD RRRRFLLLLL YWWLELYIIT NPPHQRAGRK IIIGGGGGLY GGFFGVPPPT TIDLSSLLLD RRRRFLLLLL YWWTEMYVVS DPPHNVAGSR IIIGGGGGIA GGFFGVPPPT TIDLSSMMMD RRRRFLLLLL YWWTEMYVVS DPPRKKAGSH IIIGGGGGIA GGFFGCPPPT TIDLSSLLLD KKKKYLLLLL YWWLEMYVVS DPPMNVTGKE IIIGGGGGIV GGFFKVPPPT TIDLSSMMMD RRRRFLLLLL YWWTDLYVVS DPPFEKTGKR IIIGGGGGIV PPFFKVPPPT TINLSSVVVD RRRRFLLLLL YWWTELYVVS DPPFNRTGKQ IIIGGGGGIV DDFFGVPPPT TINLSSLLLD RRRRFLLLLL YWWTELYVVS DPPFNRTGSR LLLGGGGGIV MMLLPMPGGT TILLSSLLLD RRRRFLLLLL YWWHDIYIIS NPPQKRTGQF LLLGGGGGSI MMLLPMPGGT TILLSSLLLD RRRRFLLLLL YWWHDIYIIS NPPKKRTGQF LLLGGGGGSI MMLLPMPGGT TILLSSLLLD RRRRFLLLLL YWWHDLYIIS DPPQRRTGQF LLLGGGGGSI MMLLPMPGGT TILLSSLLLD HHHHFLLLLL YWWHDIYVVS DPPQRRTGQF LLLGGGGGSI LLLLPMPGGT TILLSSLLLD RRRRFLLLLL YWWHDLYIIS DPPQRRTGQF LLLGGGGGSI LLLLPMPGGT TILLSSLLLD RRRRFLLLLL YWWHDLYIIS DPPQRR---- ---------- LLLLPMPGGT T--------- ---------- ---------- ---------- ---------- LLLLPMPGGT TILLSSLLLD RRRRFLLLLL YWWHDLYIIS DPPQRRTGQF LLLGGGGGSI MMLLPMPGGT TILLSSLLLD RRRRFLLLLL YWWHDMYIIS DPPKRRVGQF LLLGGGGGSI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGVVVLSNNP PAWIFFFFFS LLLLLIIIII I--------- ---------- ---------- AALLPMPGGT TILISSLLLD RRRRFLLLLL YWWHDIYIIT DPPRNKVGQF LLLGGGGGSI PPMMPMPGGT TILISSLLLD RRRRFLLLLL YWWHDIYIIT DTTRNKVGQF LLLGGGGGSI IILLPMPGGT TFLISSLLLD RRRRFLLLLL YWWHDIYIIE DLLKNVTGQW VVVGGGGGLI FFLLPMPGGT TFLISSLLLD RRRRFLLLLL YWWHDIYIIE DVVKNKTGQW AAAGGGGGLI IILLPMPGGT TFLISSLLLD RRRRFLLLLL YWWHDIYIIE DPPKNVTGQW VVVGGGGGLL IILLPMPGGT TFLISSLLLD RRRRFIIIII YWWHDIYIIE DPPKNVTGQW VVVGGGGGLL IILLPMPGGT TFVISSLLLD RRRRYLLLLL YWWHDIYIIE DPPAKVAGQW AAAGGGGGLL AALLPMPAAT TILISSMMMD RRRRFLLLLL YWWHDIYIIS DPPLKKNSQY IIIGGGGGSV AALLPMPAAT TILISSMMMD RRRRFLLLLL YWWHDIYIIS DPPKNKNSQF IIIGGGGGSI ---------- ---------- ---------- ---------- ---------- ---------- EEIIEMGGGT TILISSLLLD RRRRYLLLLL YWWHDVYIIS DRRANRTGQF LLLGGGGGAI VVAAEMGGGS SIIISSLLLD RRRRFLLLLL YWWHDVYIIT DPPENKTGQF LLLGGGGGAI ---------- ---------- ---------- ---------- ---------- ---------- GGNNPDIPPV VISIAAAAAD QQQQTLLLLL WFFDKTFIIS DPPHKFIYEV IIIDDDDRQV GGEEPKVPPV VISISSNNND SSSSRLLLLL WFFDKTFIIS DPPHHRVYET IIIGGGGAQV HHRAH----- ---------- AHKKTTTGPP QQMLEISRDG RVVTNSLYTW QYYYPEEEGL HHREH----- ---------- SAEETTTGPP QQMISVSRDG RVITNSLYSW QYYYP---GL RRRAH----- ---------- NRTTAAAGPP QQMVEISRDG RVWTNSLYTW QYYYPDDDGV RRRTH----- ---------- NKAAAAAAPP QQMVEISRDG RVWTNSLYTW QYYYPDDDGV KKKTH----- ---------- NKTTGGGYPP QQMVEISRDG RVWTNSLYTW QYYYPGGGDR SSRAH----- ---------- KGAANNNGPP QQMVEISRDG RVFTNSLYAV QYYYPEEEGI RRRAH----- ---------- TAEENNNGPP QQMVEISRDG RVFTNSLYAW QYYYPDDDGI RRKAH----- ---------- AGPPNNNGPP QQMVEVSRDG RVFSNSLYSW QYYYPVVVGI VVRGSVLEEL TTCCPPPPLL KKRRPPPGPP QQMIQLSLDG RLATTSLYDW QYYY-PPPDL VVKGSVLEEL TTCCPPPPLL KKRRPPPGPP QQMIQLSLDG RLVTTSLYAW QYYY-PPPNL VVKGPVLEEL KKSSPPPPLL KKKKPPPGPP QQMIQLSLDG RLVTTSLYAW QYYY-PPPDL VVKDPVLDEL DDSSPPPPLL KKQQAAAGPP QQMIQLSLDG RLVTTSLYAW QYYY-PPPDL VVKGPVLEEL KKSSPPPPLL KKRRAAAGPP QQMIQLSLDG RLITTSLYAW QYYY-PPPDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVKGPVLEEL KKSSPPPPLL KKRRAAAGPP QQMIQLSLDG RLITTSLYAW QYYY-PPPDL VVKGPVLEEL KKSSPPPPLL KKRRPPPGPP QQMIQLSLDG RIVTTSLYDW QYYY-PPPDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLRGPVLEDL EECCPPPPVV KKKKPPPGPP QQMIQLSLDG RLVTNSLYKW QYYY-PPPDM QQRGPVLEEL EECCPPPPVV KKIIPPPGPP QQMIQLSLDG RIVTSSLYIW QYYY-PPPDL QQKGPAIGGK TTWWSSSVPP QQKKRRRGPP QQMIQLTLDG RLVTNSLFAW QYYY-PPPGL QQKGPAVKGE TTWWSSSVPP QKKKRRRGPP QQMIQLSLDG RLVTNSLFAW QYYY-PPPKL QQKGPAVGGN SSFFFFFVPP KKSSRRRGPP QQMIQLSLDG RLATNSLFAW QYYY-PPPEL QQKGPAVGGN TTFFFFFVPP KKSSRRRGPP QQMIQLSLDG RLATNSLFAW SYYY-PPPEI QQKGEYVTDK EEEEYYYVPP KHRRRRRGPP QQMIQLSLDG RIVTNSLFRW QYYYGQQQDL HHTENVLEK- ----IIIALL KRKKEEEGPP QQMLQLSLDG RLVTTSLYKW QYYY-PPPEH HHSETVLEHD ----IIIALL KRQQEEEGPP QQMLQLSLDG RLVSTSLYKW QYYY-PPPEN ---------- ---------- -------GPP AAKIQLSVDG RLVTNSFYTW QYYY-PPPNV QQRDPVLNEL KKEEPPPPVV KRRRLLLGPP QQMLQLSLDG RLVSSSLFPW QYYY-PPPEM CCSDPIVKEL KKEEPPPARR KRRREEEGPP QQMLQLSLDG RLVSSSLYPW QYYY-PPPKM ---------- ---------- ---------- ---------- ---------- ---------- NN-------- ---------- ---------- --MVSQSWDG RVFSSSLLNW ---------- NN-------- ---------- ---------- --MVSSSWDG RLYTSSLLNW ---------- KGGMVVKLLA -----PPSSG LEEIKEFFFG GG-----RHQ QVVRRRLSSG GGSSSYCYPP RGGMAAKVVV -----PPEEG LEELKEFFFG GG-----RHQ QVVRRRLWWG GGSTTFCYPP PAAQVVLAAA -----PPDDG LTTLDDWWFP PPG----RHQ QIIRRRLEEG GGSTTFCYPP PGGEVVMAAV -----GGNNG LEELKDFFFP PPG----RHQ QIIRRRLEEG GGSTTFCYPP GAAMVVMAAV -----EENNG LTTLKDWWFP PPG----RHQ QIIRRRLEEG GGSTTFCYPP DGGMVVKLLA -----PPNNG IEEFPKFFWP PPG----RHQ QVVRRRLQQG GGSSSYCYPP KGGMVVKVVV -----PPDDG MQQFPNFFFG GG-----RHQ QIIRRRLQQG GGSSSYCFPP RGGIAAKAAA -----PPGGG LSSLPGFFVG GGG----RHQ QIIRRRLEEG GGSSSYCYPP IRRGSSVMMQ VVVDTVVNNG LKKLPNLLFG GGELGGPLHE ELLRRRYPPG GGSSSWI--- IRRGSSVMMQ VVVDTAANNG LKKLPNLLFG GGELGGPLHE ELLRRRYPPG GGSSSWI--- IRRGSSVMMQ VVVDTVVKKG LKKLPNLLFG GGELGGPLHE ELLRRRYPPG GGSSSWL--- IRRGSSVMMQ VVVDTVVKKG LTTLPNLLFG GGELGGPLHE ELLRRRYPPG GGSSSWL--- IRRGSSVMMQ VVVDTVVKKG LKKLPNLLFG GGELGGPLHE ELLRRRYPPG GGSSSWI--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IRRGSSVMMQ VVVDTVVKKG LKKLPNLLFG GGELGGPLHE ELLRRRYPPG GGSSSWI--- IRRGSSVMMQ VVVDTVVKKG LKKLPNLLFG GGELGGPLHE EIIRRRYPPG GGTSSWL--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IKKGSSVMMQ VVVDTEEKKG LKKLPNLLFG GGEGGGPLHE ELLRRRYPPG GGSSSWV--- LKKGAAVMMQ VVVDTKKKKG LKKLPNLLFG GGEDGGPLHE EIIRRRYPPG GGTSSWI--- VEEGSSHIIQ VVVDTEEKKG LKKIPNFFFG GGEDGGPLHE EMMRRRYPPG GGTSSWI--- VEEGSSHIIQ VVVDTEENNG LKKIPNFFFG GGEDGGPLHE EMMRRRYPPG GGTSSWI--- MDDGSSHIIQ VVVDTEEKKG LSSIPNFFFG GGEEGGPLHE EMMRRRYPPG GGTSSWI--- MEEGSSHIIQ GGGDTEEKKG LTTIPDFFFG GGEDGGPLHE EMMRRRYPPG GGTSSWI--- VKKGSSHMMQ VVVDTEEKKG LSSIPNFFFG GGEEGGPLHE EMMRRRYPPG GGTSSWI--- VKKGAATMMQ IIIDPEESSG MEEIRDLLFG GGIGGGPLHE EMMRRRYPPG GGTSSWI--- VRRGAATMMQ VVVDPIITTG MVVIKNLLFG GGVGGGPLHE EMMRRRYPPG GGTSSWI--- VKKGSSVMMQ VVVDTEEKKG LTTVKNLLFG GGENGGPLHD DIIRRRFPPC GGTSSLA--- VAAGGGTIIQ IIIDVEENNG MKKLENLLFG GGEYGGPLHE EMMRRR---- ---------- VSSGGGHIIL VVVDTVVNNG ISSLEDLLFA AAEYGGPLHE EMMRRRYPPG GGTSSWLANN ---------- ---------- ---------- ---------- ---------- ---------- -KKGKKDDDQ KKKAYNNWWD KEELEDAAFY YYLLGG-RHI IMMRRRFGGS SSYSS----- -KKGKKDDDQ KKKLYYYWWD KEELEQAAFY YYELGG-RHQ QMMRRRFGGA RRYAAAGDGG ------- ------- SSK---- SS----- SS----- ------- ------- SS----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- DD----- ------- ------- NNLAVVV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMMNNAAKAA KKQQPPEEAT PCRRTVLLLA RAADDGGGAA MQPPTALSLL TPSSSRRIII gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKKAAYYTTF FSSSIQQVVL LAAAASSSPP PRSSSSESSK KKRRKRRSVP PGGLVEIISS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMPPT TLPPLNNNNR RTTTTPPTPP PHPPPPNPPL LLPPAPPPHP PRRVPLTTLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMAVVP ---------- ---------- ---------- ---------- ---------- -------AAK ---------- ---------- ---------- ---------- ---------- -------MMS ---------- ---------- ---------- ---------- ---------- -------MMT ---------- ---------- ---------- ---------- ---------- -------MMT ---------- ---------- ---------- ---------- ---------- -------AAT ---------- ---------- ---------- ---------- ---------- -------VVT ---------- ---------- ---------- ---------- ---------- -------AAS ---------- ---------- ---------- ---------- ---------- -AAATTKTTK ---------- ---------- ---------- ---------- ---------- ---------- SSSSAVAAKK QQPSSAAAAW WWHLPPPPPG GGAAAAVVLI IAPARGLPGG GSSSTTQGGK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AAATTKGGN ---------- ---------- ----AAEEER RRAAFFTTLQ QSVAQPRPII IAAATTKGGN ---------- ---------- ---------- ---------- ---------- -AAATTKGGN ---------- ---------- ---------- ---------- ---------- -AAATTKGGN ---------- ---------- --MLGGKKKE EEHHTTAAQP PWFLSGLWQQ QAAATTKGGD ---------- ---------L LLKSQQGGGC CCDDQQTTNT TELHTYTLVV VPPPTTKGGN ---------- ---------- ---------- ---------- ---------- -AAATTKGGN LLLLVRPPYY RRNVVPRRRC CCPARRHHHS SSQQHHIIME EGAAAVTAAA AGGGKKTCCH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMMAAKGGS ---------- ---------- ---------- --------MA ATVLDHVVNN NSSS--VGGC ---------- ---------- ---------- --------MG GTVLQHVVSS SNNNNNQGGC ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MML ---------- ---------- ---------- ---------- ------MAAA AGGGAAACCG ---------- ---------- ---------- ---------- -------MSS SGGGLLKHHG ---------- ---------- ---------- ---------- -------MPP PPPPLLKHHG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMSSSK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MKKRRRR RR-------- -----AAAGG GAAAMMGPPF ---------- ---------- ---MKKRRRF FFGGPPSSMH HFALRAVSGG GAAALLAPPA FRDPFFFYYP PPKKMMKAPP PLGGTTGNNA ADDDFAVVVV NPPSTTYIII VHHHLPINDD LPDPFFFYYP PPRRMMRAPP PLGGTTGNNP PDDDFAVVVV DPPSTTYVVV IYYYLPIGDD MPDPFFFHHA APEEMMQAPA ALDDFFS--P PDDDAAVIIV KPPSTTYIII VHHHMPTGDD MPDPFFFHHA APKKMMEAPA ALDDFFS--P PDDDAAVIIV KPPSTTYIII VHHHMPKGDD LPDPFFFYYP PAKKMMEGPV VLDDAAS--P PDDDGAVVVV DPPSKKFIII VHHHMPKGDD WPDPFFFYYP PPRRAAKAPP PFEERRK--P PDDDAAVVVV DPPSRRYIII VGGGMPAGDD WPDPFFFYYP PPRRVVKAPA ALMMAAN--P PDDDACVVVV DSSSTTFVVV VGGGMPTGGG WPDPFFFYYP PPKKMMQAPR RLGGRRE--P PDDDAGVLLL DPPSTTYIII VGGGMPAADD -CGPYYYPPT TLEEKK-GPR RINNTTGEEP PDDDYATVVV DPPSQQYVVV IHHHMPLKDD ---------- ----MM-GPR RINNTTGEEP PDDDYATVVV DPPSHHYVVV IHHHMPLKDD -CGPYYYPPS SLEEKK-GPR RINNTTGEEP PDDDYATVVI DPPSQQYVVV IHHHMPLRDD ---------- ----KK-GPR RINNTTGEEP PDDDYATVVV DPPSQQYVVV IHHHMPLKDD -CGPYYYSST TLEEKK-GPR RINNTTGEEP PDDDYATVVV DPPSQQYVVV IHHHMPLKDD -CGPYYYSST TLEEKK-GPR RINNTTGEEP PDDDYATVVV DPPSQQYVVV IEEE------ -CGPYYYSST TLEEKK-G-- -------EEP PDDDYATVVV DPPSQQYVVV IHHHMPLKDD -CGPYYYSST TLEEKK-GPR RINNTTGEEP PDDDYATVVV DPPSQQYVVV IHHHMPLKDD -CGPYYYPPT TQEEKK-GPR RINNTTGEEP PDDDYATVVV DPPSQQYVVV IHHHMPLKDD -CGPYYYSST TLEEKK-GPR RINNTTGEEP PDDDYATVVV DPPSQQYVVV IHHHMPLKDD -CGPYYYSST TLEEKK-GPR RINNTTGEEP PDDDYATVVV DPPSQQYVVV IHHHMPLKDD TKGPYYYAAT TLEEEEKGPR RVGGTTGNNL LDDDYATVVL DPPSTTYVVV IHHHVIIGDD ---------- ---------- ---------- ---------- ---------- ----MPTNDD -CGPYYYKKS SLDDKK-GPR RISSTTGNNP PDDDYATVVV DPPSSSYVVV IHHHMPVNDD CSGPYYYAAS SIEESS-GPR RVGGTTGEEP PDDDYATVVV DPPSTTYVVV IHHHVPVGDD CSGPYYYAAS SLEESS-GPR RVGGTTGEEP PDDDYATVVL DPPSTTYVVV IHHHVPVGDD ---------- ---------- ---------- ---------- ---------- ----MPVGDD QGGPYYYAAT TLAASS-GPS SVGGTTGDDP PDDDYATVVV DPPSSSYVVV IHHHMPVGDD GTGPYYYAAT TLEEEEKGPR RVGGTTGNNP PDDDYGTVVV DPPSTTYVVV IHHHVTVGDD --GPYYYAAS SADDKK-GPR RP--NNADDP PDDDAFTVVV NPPSTTFVVV ISSSVPIGDD --GPYYYAAS SADDKK-GPR RP--HHADDP PDDDAFTVVV NPPSTTFIII ISSSVPIGDD ---------- ---------- ---------- ---------- ---------- ---------- CCGPYYYAAT TLDDRRNGPV VVNNLLDEEG GDDDYATVVV DPPSTTYVVV IHHHTNKHNN ---------- ----RRSGPR RVNNLLDPPG GDDDYSTVVV DPPSTTYIII VHHHTNKGDD --MPLLLIIT T-DDIISLDD DLDDIIRYYI ITTTDKNPPM VGGVLLGVVV LKKKVKLEDD RFADTTTCCQ QPYYKKITGQ QLEEGGMDDQ QDDDKVTIIL RPPSTTRVVV INNNVG-RNN GRADTTTCCA APYYKKITGQ QLEEGGVDDQ QDDDKVTVVA NPPSQQYVVV VNNNVG-RNN DLLLLLHHFG GWNCCCSSAA C---KPRLLI PPPGRSRRII YIIIIKNPPR RKIIKVEEVV DLLLLLHHFG GWNCCCSSAA C---KPRLLI PPPARSRRII YIIVVKDKKR RAVAKIEEAA DFFFFFHHFG GWNCCCSSSS SGGGHARLLI PPPGRSRRII YVVIIKHPPT TRIHKIEDII DFFFFFHHFG GWNCCCSSAA SGGGHARLLI PPPGRSRRII YIIIIKDPPT TKIHKIEEVV DFFFFFHHFG GWNCCCSSAA SGGGHARLLI PPPGRSRRII YIIVVKEPPL LKIHKIEEVV DLLLLLHHFG GWNCCCSSCC CPPPHPRLLV PPPGRSRRII YIILLKDPPL LFLAKVEELL GLLLLLHHFG GWNCCCSSMM CPPPHPRLLV PPPDRSHHII TIILLKDPPT TKVVKVDNLL DLLLLLHHFG GWNCCCSSAA CPPPHPRLLI PPPGRSRRII HIIVVKDPPR RRIVKVEELL DLLLLLHHSG GWNCCCSSCC -GGGDSRLLI PPPGMSRRII YVVVVGEPPR RKLHKVESII DLLLLLHHSG GWNCCCSSCC -GGGDSRLLI PPPSISRRII YVVVVGEPPR RKLHKVENII DLLLLLHHSG GWNCCCSSCC -GGGDSRLLM PPPCMSRRII YVVVVGDPPR RKLHKVEEII DLLLLLHHSG GWNCCCSSCC -GGGDIRLLV PPPAISRRII YVVVVGEPPR RKLHKVEKII DLLLLLHHSG GWNCCCSSCC -GGGDSRLLV PPPSISRRII YVVVVGEPPR RKLHKVEEII ---------- ---------- ---------- ---------- ---------- -------KII DLLLLLHHSG GWNCCCSSCC -GGGDSRLLV PPPSISRRII YVVVVGEPPR RKLHKVEKII DLLLLLHHSG GWNCCCSSCC -GGGDSRLLV PPPSISRRII YVVVVGEPPR RKLHKVEKII DLLLLLHHSG GWNCCCSSCC -GGGDSRLLV PPPSISRRII YVVVVGEPPR RKLHKVEKII DLLLLLHHSG GWNCCCSSCC -GGGDSRLLV PPPS------ ---------- ---------- DLLLLLHHSG GWNCCCSSCC -GGGDSRLLV PPPSISRRII YVVVVGEPPR RKLHKVEKII DLLLLLHHSG GWNCCCSSCC -GGGDPRLLI PPPSLSRRVV YVVVVADPPR RSLHKVEEII DLLLLLHHSG GWNCCCSSCC -GGGDARLLI PPPCISRRII YVVVVGDPPR RRIHKTEYVV DLLLLLHHSG GWNCCCSSCC -GGGDSRLLI PPPCISRRII YVVVVGDPPR RRIHKTEYVV DLLLLLHHTG GWNCCCSSCC -GGGDPRLLI PPPSVSRRII YVVIIKNPPR RSLHKVDAII DLLLLLHHTG GWNCCCSSCC -GGGDPRLLI PPPGVSRRVV YVVIIKNPPR RSLHKVEEII DLLLLLHHSG GWNCCCSSCC -GGGDARLLV PPPSISRRII YAAIIKNPPR RSLYKYDKII DLLLLLHHSG GWNCCCSSCC -GGGDARLLV PPPSISRRII YAAIIKNPPR RSLYKYDKII DLLLLLHHSG GWNCCCSSCC -GGGDPRLLI PPPSLSRRVV YVVVVLDPPR RALHKVEEII DVVVVVHHTG GWNCCCSSCC -DDDKPRLLI PPPCNSRRII YIIIIEE--R RYLEHTESLL DVVVVVHHTG GWNCCCSSCC -DDDKPRLLI PPPCNSRRII YVVIIEE--R RYLQHTESLL ---------- ---------- -------MMV RRRKSSVVEE GKKVVG---- ---------- NLLLLLHHSG GWNCCCSSCC FGGGKERLLV PPPCNSRRII FVVIIGDPPR RKLAKVE-VV DLLLLLHHSG GWNCCCSSCC YSSSKTRLLV PPPSNSFFII YIILLVDPPR REIVKTD-VV DEEEEELDSQ QPTRRRIIKK -GGGKRGMML LLLSDGRRLL YVVTTLSAAW WQFYP---LL NAAAAAHHGG GFS------- ------RFFW GGGGDTRRII FIIFFHDPPS SKLHKTD-VV NAAAAAHHSD DFT------- ------RLLW GGGGDTKKII FVVFFHDPPA AVLSKTT-VV KKVVHTVVGA AAYISALGGN N----EGEEG IIILMDDYYF EPLKWGQ--- ---------- VVRRHTVVGA AAYISALGGG G----DGEEG IIIFLDDDDF EPIRWGQ--- ---------- LLKKHTVVGG GGYVSTLGGG GGGGKDGDDP IIIFIDDEEF DVLRWGQ--- ---------- FFKKHTIIGG GGYVSTLGGG GGGGKDGNNP VVVFIDDEEF EVLRWGQ--- ---------- FFKKHTIIGG GGYVSTLGGG GGGGEDGDDP IIIFIDDEEF EILRYGQ--- ---------- AARRHTVVGG GGYVTALGGN N----EGKKG IIIAMDDQQF EPLRWGQ--- ---------- AARRHTVVGG GGYISALGGS S----EGEEG IIIFIDDDDL EVLRWGQ--- ---------- HHRRHTIIGG GGYVSALGGS S----EGDDG VVVFVDDEEF DPLRWGQ--- ---------- QQKKHTSSLG GGVMVNTLLG G----LQNNG FFFVLDDEEF EVKTWGS--- ---------- HHKKHTSSLG GGVMISSLLG G----PQNNG FFFVLDDEEF EVKTWGA--- ---------- HHKKHTSSLG GGVMISTLLG G----SKNNG FFFVLDDEEF EVKTWGA--- ---------- HHKKHTSSLG GGVMVSTLLG G----PENNG FFFVLDDKKF EVKTWGA--- ---------- HHKKHTSSLG GGVMISSLLG G----VKNNG FFFVLDDEEF EVKTWGA--- ---------- HHKKHTSSLG GGVMISSLLG G----VKNNG FFFVLDDEEF EVKTWGA--- ---------- HHKKHTSSLG GGVMISSLLG G----VKNNG FFFVLDDEEF EVKTWGA--- ---------- HHKKHTSSLG GGVMISSLLG G----VKNNG FFFVLDDEEF EVKTWGA--- ---------- HHKKHTSSLG GGVMISTLLG G----PKNNG FFFVLDDEEF EVKTWGA--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- HHKKHTSSLG GGVMISSLLG G----VKNND SSSLVLL--L ECS------- ---------- AANNHTSSLG GGIMISCLLG G----KENNG GGGFLLLSSF NVKRGFI--- ---------- FFKKHTSSLG GGIMISSIIG G----PYNNG FFFVLDDEEF EVKNWEA--- ---------- FFKKHTSSLG GGIMISSLLG G----PCNNG FFFVLDDEEF EVKNWEA--- ---------- IIKKHTSSLG GGLMISCLLG G----KDNNG GGGFLLLSSF NVKRWHP--- ---------- SSKKHTSSLG GGIMISCIIG G----KDNNG GGGFLLLSSF NVKRWHP--- ---------- AAKKHTAALG GGILVSCLLG G----EENNG GGGFLLLSSF NIKRWHP--- ---------- AAKKHTAARG GGILVSCLLG G----EENNG GGGLLLLSSF NIKRWIP--- ---------- AAKKHTSSLG GGIMISCLLG G----KENNG GGGFLLLSSF NVKRWHP--- ---------- HHLLHTSSLG GGIMISTLLG G----ANTTG FFFLLDDKKF EPKTWKV--- ---------- HHLLHTSSLG GGIMISTLLG G----ADSSG FFFLLDDKKF EPKTWKV--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLGGHTTTLG GGIMISIMMG G----AENNG DDDFVFFKKF ELVTWRA--- ---------- LLSSHTTTLG GGIMISVMMG G----AEYYG DDDFIFFSSF NCITWKA--- ---------- IIFFHTAAQT TTLKQDGVVN N----SLVVL GGGIQSSHHN GLSKGFE--- ---------- KKSSHTFFLS SSMITGLSSN N----DDGGT LLLVENNDDE YVAYWDMGAA AGGDDVVVVA EESSHTLLLR RRLITGLSSN N----KDGGT LLLVETTAAE YVAHWGLGAA KGG--YYYYA --AADFFFN- PNEVVLSSSS AAVVPN---- --TEED---- LLELLKYGRR HHHFFWDDLL --AADFFFN- PSGVVMTTTS TTVVPR---- --CEEE---- LLELLKYGKK HHHVVWDDLL --HHDFFFN- PRDYYMSSSS AALLPP---- --QEEN---- PPELLLYGRR HHHFFWDDLL --HHDFFFN- PRDYYMTTTS AALLPP---- --QEEN---- PPELLLYGRR HHHFFWDDLL --HHDFFFN- PRDYYMSSSS GGLLPP---- --QEEN---- PPELLLYGKK HHHFFWKKLL --AADGGGH- GYDTTLTTTS GGTTPD---- --MEED---- PPDLLLYGRR HHHFFWDDLL --HHDFFFH- GYDTTLTTTS GGTTPR---- --MEES---- GGDLLLYGRR HHHVVWDDLL --AADFFFH- GYDTTMTTTS GGTTPN---- --MEEG---- PPQLLLYGRR HHHIIWDDLL --GGDFFFQ- RHNVVMSSST AAAAPN---- --VKKDFFFF AAHEEAYGRR FFFVVWDDWW --GGDFFFQ- RHNIIMSSST AAAAPN---- --VKKDFFFF AAHEEAYGHH HHHVVWDDWW --GGDFFFQ- RHNVVMSSST AAAAPN---- --VRRDFFFF AADEEAYGHH HHHVVWDDWW --GGDFFFQ- RHNVVMSSST AAAAPN---- --VRRDFFFF AADKKAYGHH YYYVVWDDWW --GGDFFFQ- RHNVVMSSST AAAAPN---- --VRRDFFFF AADEEAYGHH YYYVVWDDWW --GGDFFFQ- RHNVVMSSST AAAAPN---- --VRRDFFFF AADEEAYGHH YYYVVWDDWW --GGDFFFQ- RHNVVMSSST AAAAPN---- --VRRDFFFF AADEEAYGHH YYYVVWDDWW --GGDFFFQ- RHNVVMSSST AAAAPN---- --VRRDFFFF AADEEAYGHH YYYVVWDDWW --GGDFFFQ- RHNVVMSSST AAAAPN---- --VQQNFFFF AADEEAYGHH HHHVVWDDWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A AAHHSN---- --LLLTSSSS YYPSSAVAII ---------- --EETHHHEY AWGLLFSSSW CCCCSL---- --FTTTAAAA MMCTTAVHII CCCLLDNNYY --GGDFFFQ- RHNVVMSSST GGAAPK---- --AAALFFFF EEEQQAYGSS NNNVVWDDWW --GGDFFFQ- RHNVVMSSST GGAAPK---- --AAALFFFF EEDQQAYGSS NNNVVWDDWW --GGDFFFQ- RHNTTMSSST GGAAPT---- --ATTKFFFF QQHAADYGHH TTTCCIQQLL --GGDFFFQ- RHNTTMSSST GGAAPK---- --ALLQFFFF QQHAADYGHH HHHVVYSSWW --GGDFFFQ- RHKTTMSSST GGAAPK---- --ASSKFFFF QQHAADYGHH HHHVVYSSWW --GGHFFFQ- RHKTTMSSST GGAAPK---- --ASSKFFFF QQHAADYGHH HHHVVYSSWW --GGDYYYQ- RHKTTMSSSS GGAAPA---- --ARRTFFFF QQHQQDYGHH HHHVVYDDWW --NNDFFFQ- RRNVVMSSST GGSSPN---- --HKKKFFFF AAHGGEYGSS HHHIIFEEWW --NNDFFFQ- RRNIIMSSST GGSSPN---- --HKKKFFFF AAHPPEYGSS HHHIIFEEWW ---------- ------SSSI GGGGPV---- --TCCREEEE KKCPPEVICC RRRVVY---- --GGDYYYQ- HFNVVMAAAS GGAAPK---- --LRRRYYYY TTDDDDYGRR NNNFFYRRWW --GGDFFFQ- YFDVVMSSSS GGAAPN---- --KRRRWWWW VVDEEDYGRR NNNFFYKKWW --QQSNNNN- -REKKSSSSD DDEEPI---- --MFFESSSS FFLKKTKPHH AAAEEVLL-- DGGGDIIIL- RKNVVMTTTS TTGGWSNNNN YYMDDFQQQQ QQDEEAFGTT VVVQQWDDLL DGDDDVVVL- RKNLLLTTTS TTGGWNNNNN YYMDDFKKKK AADEEAFGTT VVVTTWDDLL LLLLRKKRII LLTENNRAAA A-------ER RLHDTMFIIM VLKDSSSSII WWWFFEEGGW LLLLAKKHLL IIDQHHRVVV V-------ER RLHDTMFVVV VTKDSSSSII WWWFFEEGGW LLLLRAANVV IIDAHHQAAA A-------ER RAHDVYFVVV VTTNEESSII WWWWWEEGGF LLLLRAANVV IIDAHHQAAA A-------ER RAHDVYFVVV VTTNEESSII WWWWWEEGGF LLLLRDDNVV IIDAHHQAAA A-------ER RAHDSYFCCV VTTNQQAAII FWWWWDDGGF LLLLTRRHLL IIDDHHQVVV V-------ER RAHDTYFVVC VLKDSSSSII WWWYYDDDDW LLLLYRRHLL LLDAYYQAAA A-------ER RAHDTYFMMC VLKDSSSSII WWWYYDDGGW LLLLRRRHLL LLDEHHQVVV V-------ER RAHDAYFVVV VLEDSSSSVV WWWHHQQGGW WWWWQRRIII LLQ-DDGIII I------LER RLHDSQFVVC ASNIRRYYKK NEEGG----- WWWWQRRIII LLQ-DDGIII I------LER RLHDDQFVVC ASNIRRYYKK NGGGG----- WWWWQRRIII LLT-DDGIII I------LER RLHNDQFVVC ASTIRRYYKK NGGGG----- WWWWQRRIVV LLP-DDGIII I------LER RLHNDQFVVC ASTIRRFFKK NDDGG----- WWWWQHHIVV LLS-DDGIII I------LER RLHNDQFVVC ASTIRRYYKK NGGGG----- WWWWQRRIVV LLS-DDGIII I------LER RLHNDQFVVC ASTIRRYYKK NGGGG----- WWWWQRRIVV LLS-DDGIII I------LER RLHNDQFVVC ASTIRRYYKK NGGGG----- WWWWQRRIVV LLS-DDGIII I------LER RLHNDQFVVC ASTIRRYYKK NGGGG----- WWWWQRRIVV LLL-DDGIII I------LER RLHDAQFVVC ASTIRRYYKK NGGGG----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYYYIMMIDD LLP-DDQGGG GNNPPIILCR RIHWNQYDDV EFSGGGSSDD PAAYY----- WWWWTEERII IIDEDDGIII I------LER RLHDDQLVVC ASTVRRYYKK EDDGG----- WWWWTEELVV IIDKDDGIII I------LER RLHNDQLVVC ASSIRRYYKK EDDGG----- LLLLARRLRR LLDNTTGLLL L------LER RLHDATFVVS ASNMRRFFKK TDDGG----- WWWWPGGIKK LLDDKKGLLL L------LER RLHDATFVVS ASNMRRFFKK TDDGG----- WWWWPGGMKK IIDETTGLLL L------LER RLHDSTYVVS ASNMRRFFKK NDDDD----- WWWWPGGIKK IIDPTTGLLL L------LER RLHDSTFVVS ASNMRRFFKK NDDEE----- WWWWPGGLKK LLDSTTGLLL L------LER RLHDSTYVVC ASNMRRFFKK TDDGG----- WWWWDSSYLL IIDQLLGLLL L------LER RLHETHFVVC ASGIRRHHPP VEENN----- WWWWDTTHLL IIDMRRGLLL L------LER RLHETHFVVC ASAIRRHHPP DKKNN----- ---------- ---------- ---------- ---------- ---------- ---------- WWWWQEELFF IIDDDDGTTT T------LER RLHNRQYVVC AXXXXXXX-- ---------- WWWWSTTLYY IIDSDDGTTT T------LER RLHNKEFVVC AAKVHHKKKK KDDSS----- ---------- ---------- ---------- ---------- ---------- ---------- LLLLHTTPKK FFNGPP---- -------LER RPWGNYFSST ASQLLLYYEE DAAGG----- LLLLHTTPKK FFDGPP---- -------LER RAWGAYFTTT ASQLLLYYEE DEEGG----- AAAAEKVIEI IIALGNELKV VPPPVVTIID DSLLDDDFLY YSSSSIGEER QQQQSNPFKP AAAAERVIDI IIAFGPPLKV VPPPVVTIID DSLLDDDFLY YSSSSLGEER QQQQTNPHQP VVVVKKTATI IIAAAEPLGV VPPPVVTIID DSLLDDDFLY YSSSSTGEER QQQQSDPHNP AAAAEKTATI IIPAKKPLGV VPPPVVTIID DSMMDDDFLY YSSSSTGEER QQQQSDPRKP AAAAKKTITI IIPAADDLGC CPPPVVTIID DSLLDDDYLY YAAAALGEEH QQQQSDPMNP VVVVRKVIEI IIAAPQPLKV VPPPVVTIID DSMMDDDFLY YSSSSTGDDL QQQQSDPFEP LLLLKKVIDI IIAAEQPLKV VPPPVVTIIN NSVVDDDFLY YSSSSTGEEH QQQQSDPFNP IIIIRKVIEI IIAAPQPLGV VPPPVVTIIN NSLLDDDFLY YSSSSTGEER QQQQSDPFNP -------TWS SSEIVSVGPM MPGGIITIIL LSLLDDDFLY YSSSSHGDDR QQQQSNPQKP -------TWS SSEIVSVGPM MPGGIITIIL LSLLDDDFLY YSSSSHGDDR QQQQSNPKKP -------TWS SSEIVPVGPM MPGGIITIIL LSLLDDDFLY YSSSSHGDDR QQQQSDPQRP -------TWS SSQIVPVGPM MPGGIITIIL LSLLDDDFLY YSSSSHGDDR QQQQSDPQRP -------TWS SSEIVPVGPM MPGGIITIIL LSLLDDDFLY YSSSSHGDDR QQQQSDPQRP -------TWS SSEIVPVGPM MPGGIITIIL LSLLDDDFLY YSSSSHGDDR QQQQSDPQRP -------TWS SSEIVPVGPM MPGGIIT--- ---------- ---------- ---------- -------TWS SSEIVPVGPM MPGGIITIIL LSLLDDDFLY YSSSSHGDDR QQQQSDPQRP -------TWS SSEIVPVGPM MPGGIITIIL LSLLDDDFLY YNNNNHGDDR QQQQSDPKRP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AVV VVKLLYVKVL LSNNFFPAAW WFFFSSDLII ILLLL----- ---------- -------KWA AAEIVSVGPM MPGGIITIIL LSLLDDDFLY YSSSSHGDDR QQQQTDPRNP -------KWA AAEIVSVGPM MPGGIITIIL LSLLDDDFLY YSSSSHGDDR QQQQTDTRNP -------SWS SSEIVPVNPM MPGGIITFFL LSLLDDDFLY YVVVVHGDDR QQQQEDLKNP -------SWN NNEIVPVNPM MPGGIITFFL LSLLDDDFLY YVVVVHGDDR QQQQEDVKNP -------TWS SSEIVPVNPM MPGGIITFFL LSLLDDDFLY YVVVVHGDDR QQQQEDPKNP -------TWS SSEIVPVNPM MPGGIITFFL LSLLDDDFIY YVVVVHGDDR QQQQEDPKNP -------SWS SSEIIPVNPM MPGGIITFFV VSLLDDDYLY YVVVVHGDDR QQQQEDPAKP -----T-THA AATAISVGPM MPAAIITIIL LSMMDDDFLY YSSSSHGDDR QQQQSDPLKV -----K-VQT TTSAISVNPM MPAAIITIIL LSMMDDDFLY YSSSSHGDDR QQQQSDPKNP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------GNEM MGGGMMTIIL LSLLDDDYLY YSSSSHGDDR QQQQSDRANP -----EFEAK KKVIGLTSEM MGGGIISIII ISLLDDDFLY YNNNNHGDDR QQQQTDPENP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----WAVDPD DIPPPPVIIS SAAADDDTLW WNNNNDGKKR LLLLSDPHKP ---------- ----WAVDPK KVPPPPVIIS SSNNDDDRLW WNNNNDGKKR LLLLSDPHHP PLTTVVVKLG GGFFHHDDDH HPP------- -----KLTTG PPPPMMMLEE IIRRGGGYTN PLAAVVVKIG GGYYHHPPPH HPP------- -----EATTG PPPPMMMISS VVRRGGGYTN PLAAVVVRIG GGAARRPPPH HPP------- -----TFAAG PPPPMMMVEE IIRRGGGYTN PLAAVVVHIG GGAARRPPPH HPP------- -----AFAAA PPPPMMMVEE IIRRGGGYTN PLTTVVVEIG GGVVKKPPPH HPP------- -----TFGGY PPPPMMMVEE IIRRGGGYTN PLTTVVVRIG GGVVSSTTTH HPPGG----- -----ALNNG PPPPMMMVEE IIRRGGGYTN PLTTVVVQIG GGVVRRGGGH HPP------- -----ELNNG PPPPMMMVEE IIRRGGGYTN PHTTVVVRLG GGVVRRAAAH HPP------- -----PLNNG PPPPMMMVEE VVRRGGGYSN PLTTIIIFLG GGIIVVGGGS SVVQQE-QLC CPELLRIPPG PPPPMMMIQQ LLLLGGGYTT PLTTIIIFLG GGIIVVGGGS SVVQQE-QLC CPELLRVPPG PPPPMMMIQQ LLLLGGGYTT PLTTLLLFLG GGIIVVGGGP PVVQQE-QLS SPELLKVPPG PPPPMMMIQQ LLLLGGGYTT PLTTLLLFLG GGIIVVGGGP PVVQQD-QLS SPELLQVAAG PPPPMMMIQQ LLLLGGGYTT PLTTLLLFLG GGIIVVGGGP PVVQQE-QLS SPELLRVAAG PPPPMMMIQQ LLLLGGGYTT PL-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PLTTLLLFLG GGIIVVGGGP PVVQQE-ELS SPELLRVAAG PPPPMMMIQQ LLLLGGGYTT PLVVIIIFLG GGIIVVGGGP PVVQQE-QLS SPELLRVPPG PPPPMMMIQQ LLLLGGGYTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PLVVIIIFLG GGIILLGGGP PVVTTE-KLC CPDVVKVPPG PPPPMMMIQQ LLLLGGGYTN PLVVIIIFLG GGIIQQGGGP PVVTTE-KLC CPDVVIIPPG PPPPMMMIQQ LLLLGGGYTS PLTTLLLWVG GGIIQQSSSP PVVAAG-DKW WSDPPKLRRG PPPPMMMIQQ LLLLGGGYTN PLTTVVVWAG GGIIQQSSSP PVVVVK-DEW WSDPPKLRRG PPPPMMMIQQ LLLLGGGYTN PLTTIIIWVG GGLLQQSSSP PVVKKG-DNF FFDPPSLRRG PPPPMMMIQQ LLLLGGGYTN PLTTIIIWVG GGLLQQSSSP PVVKKG-DNF FFEPPSLRRG PPPPMMMIQQ LLLLGGGYTN PLAAVVVWAG GGLLQQSSSE EVVVVT-DKE EYSPPRLRRG PPPPMMMIQQ LLLLGGGYTN VLNNVVVYIG GGVVHHSSSN NVVKKE-E-- -IELLKIEEG PPPPMMMLQQ LLLLGGGYTT PLNNVVVFIG GGIIHHTTTT TVVKKE-DD- -IPLLQIEEG PPPPMMMLQQ LLLLGGGYST ---------- ---------- ---------- ---------G PPPPKKKIQQ LLVVGGGYTN PLTTVVVFLG GGIIQQAAAP PRRRRN-PLE EPEVVRLLLG PPPPMMMLQQ LLLLGGGYSS PLTTLLLFLG GGIICCLLLP PNNVVKEKLE EPPRRRLEEG PPPPMMMLQQ LLLLGGGYSS ---------- ---------- ---------- ---------- ---------- ---------- PQIIKKKVID RRVVNN---- ---------- ---------- ----MMMVSS QQWWGGGYSS PQVVKKKTIG AAVVNN---- ---------- ---------- ----MMMVSS SSWWGGGYTS LSTWDNYYPE LLLLGMVKLN --PSGGKFFV VDFGE----- -AARHRRSGG ASDSSCCP-- LSSWNNYYP- LLLLGMAKVN --PEGGKFFV VDFGR----- -AARHRRWGG ATDSSCCP-- LSTWDDYYPD VVVVAQVLAH --PDGGDYYV VEFPDG---- -YYRHRREGG CTDSSCCPSV LSTWDDYYPD VVVVGEVMAN --GNGGKYYV VSFPDG---- -YYRHRREGG CTDSSCCPSV LSTWDEYYPG RRRRAMVMAN --ENGGKFFV VDFPAG---- -YYRHRREGG CTDSSCCPSV LGAVDPYYPE IIIIGMVKLD --PNGGPFFL LEWPKG---- -HHRHRRQGG CSDSSCCP-- LRAWDEYYPD IIIIGMVKVD --PDGGPFFV VDFGE----- -QQRHRRQGG ASDSSCCP-- LASWDEYYPV IIIIGIAKAE --PGGGPFFT TEVGDG---- -LLRHRREGG SSDSSCCPS- LSDWDKYY-P LLLLRGSVML DTVNGGPFFV VDFGKEPPPL GAALHRRPGG CSDIIII--- LSAWDKYY-P LLLLRGSVML DTANGGPFFV VDFGKEPPPL GAALHRRPGG CSDIIII--- LSAWDKYY-P LLLLRGSVML DTVKGGPFFV VDFGKEPPPL GAALHRRPGG CSDIILL--- LSAWDKYY-P LLLLRGSVML DTVKGGPFFV VDFGKEPPPL GAALHRRPGG CSDIILL--- LSAWDKYY-P LLLLRGSVML DTVKGGPFFV VDFGKEPPPL GAALHRRPGG CSDIIII--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LSAWDKYY-P LLLLRGSVML DTVKGGPFFV VDFGKEPPPL GAALHRRPGG CSDIIII--- LSDWDKYY-P LLLLRGSVML DTVKGGPFFV VDFGKEPPPL GAALHRRPGG CSDIILL--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LSKWDKYY-P MMMMKGSVML DTEKGGPFFV VDFGKEPPPG GVVLHRRPGG CSDIIVV--- LSIWDKYY-P LLLLKGAVML DTKKGGPFFV VDFGKEPPPD GVVLHRRPGG CSDIIII--- LSAWDKYY-P LLLLEGSHIL DTEKGGPFFV VDFGAEPPPD GAALHRRPGG CSDIIII--- LSAWDKYY-P LLLLEGSHIL DTENGGPFFV VDFGAEPPPD GSSLHRRPGG CSDIIII--- LSAWDRYY-P LLLLDGSHII DTEKGGPFFV VDFGDEPPPE GAALHRRPGG CSDIIII--- LSAWVVYY-P IIIIEGSHII DTEKGGPFFV VDFGDEPPPD GSSLHRRPGG CSDIIII--- LSRWDEYYGQ LLLLKGSHML DTEKGGPFFV VDFGAEPPPE GSSLHRRPGG CSDIIII--- LKKWDDYY-P HHHHKGATMV DPESKKRFFI IDFGKIEEEG GYYLHRRPGG CSDIIII--- LKKWDDYY-P NNNNRGATML DPITHHKFFI IDFGKVPPPG GYYLHRRPGG CSDIIII--- FSTWDKYY-P VVVVKGSVML DTEKGGKFFV VDFGKEPPPN GCCLHRRPCG SSDIIAA--- LSPWDKYY-P MMMMAGGTIV DVENGGEFFV VDFGGEPPPY GGGLHRR--- ---------- LSPWDKYY-P MMMMSGGHIV DTVNGGEFFV VDFANEPPPY GSSLHRRPGG CSDIILLNDA ---------- ---------- ---------- ---------- ---------- ---------- LANWD----- ----KGKDDA AYNWGGEFFV VDFYELGGGL G--RHRRGSS LSS------- LANWD----- ----KGKDDE LYYWGGEFFI IDFYAEKKKL G--RHRRGAR LAGPPGGGNR ------- ------- KKR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLVQRVV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158AKAKKQQPSS EEEAPPPRRT AAAAVTTTTT TTAALADGGA MMMQQSLPTT AAQLLLLTPG gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SPVRRKAAAA YEAFFAIQQL LLASRSKKTR PGISVAKKKQ QVVPSQAVVA HHWWPPPPKH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----AAEEAE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMGGGGKKEP ---------- ---------- ---------- ---------- ---------L KKNNQQGGLG ---------- ---------- ---------- ---------- ---------- ---------- ---------- MGRTTPLNNR RRTPHPLASP PRTRRPYYYR RTINVPPLLP PPHHRRHHLV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----KKRREF ---------- ---------- ---------- ---------- ---------- ----KKRRIV ---------- ---------- ----MMAVVF KRRDPFYPPP KKMMAAMMKK AAPPPPPDDL ---------- ---------- -------AAL KPPDPFYPPP RRDDAAMMRR AAPPPPPDDI ---------- ---------- -------MMM RPPDPFHAAA EELLAAMMQQ AAPPPPAEEF ---------- ---------- -------MMM RPPDPFHAAA KKLLAAMMEE AAPPPPANNF ---------- ---------- -------MML RPPDPFYPPP KKLLAAMMEE GGPPPPVKKL ---------- ---------- -------AAW KPPDPFYPPP RRLLAAAAKK AAPPPPPTTI ---------- ---------- -------VVW RPPDPFYPPP RRMMAAVVKK AAPPPPAKKL ---------- ---------- -------AAW RPPDPFYPPP KKMMAAMMQQ AAPPPPRRRL ---------- ---------- --MATTKTT- -CCGPYPTTT EEAAMMKK-- GGPPPPREEI ---------- ---------- ---------- ---------- ------MM-- GGPPPPREEI HHGAAVIIAA AAPPARLPP- -AHSTTQGG- -CCGPYPSSS EEAAMMKK-- GGPPPPREEI ---------- ---------- ---------- ---------- ----MMKK-- GGPPPPREEI ---------- ---------- --MATTKGG- -CCGPYSTTT EEAAMMKK-- GGPPPPREEI EEGFFTQQSS SSVVAQRPPA ASTATTKGG- -CCGPYSTTT EEAAMMKK-- GGPPPPREEI ---------- ---------- --MATTKGG- -CCGPYSTTT EEAAMMKK-- GG-------- ---------- ---------- --MATTKGG- -CCGPYSTTT EEAAMMKK-- GGPPPPREEI PPGTTAPPWW WWFFLSLWWE EDTATTKGG- -CCGPYPTTT EEAAMMKK-- GGPPPPREEI GGFQQTTTEE EELLHTTLLF FTSPTTKGG- -CCGPYSTTT EEAAMMKK-- GGPPPPREEI ---------- ---------- --MATTKGG- -CCGPYSTTT EEAAMMKK-- GGPPPPREEI VVLHHIEEGG GGAAAATAAA AANGKKTCCT AKKGPYATTT EEAAMMEEKK GGPPPPRKKL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MAAKGG- -CCGPYKSSS DDAAMMKK-- GGPPPPREEI ------AATT TTVVLDVVVE EKKS--VGGC KSSGPYASSS EESSMMSS-- GGPPPPRSSL ------GGTT TTVVLQVVVE EKVNNNQGGC KSSGPYASSS EEAAMMSS-- GGPPPPRTTL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMQ VGGGPYATTT AAAAMMSS-- GGPPPPSKKL ---------- ------MAAA AANGAAACCG ATTGPYATTT EEAAMMEEKK GGPPPPRKKL ---------- -------MMP PNCGLLKHH- ---GPYASSS DDAAIIKK-- GGPPPPREEV ---------- -------MM- --CPLLKHH- ---GPYASSS DDAAIIKK-- GGPPPPREEV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMSSSC KCCGPYATTT DDAAVVRRNN GGPPPPVKKL ---------- ---------- ---------- ---------- ----MMRRSS GGPPPPRKKL ---------- ---------- ---------- ---MPLITTT DDIILLIISS LLDDDDDFFL FFG------- ------AAA- -ALAMMGPPR AFFADTCQQQ YYMMPPKKII TTGGGGQEEF VVSPPSHHFF FFAALRVSSL LALALLAPPG VRRADTCAAA YYMMKKKKII TTGGGGQDDY YVAAACCLYT TTGRAVVVVN ESKIVHKVEY NEELLLHHFF WNACSSA-NG G--KKKKIER YVAAAAALYV VVGAAVVVVD PGKVIYKLDY GEELLLHHFF WNACSSA-NA A--KKKKLER YTLLLLLLSP PPDRAVIVVK SGKIVHTVTN GEEFFFHHFF WNACSSS-LT TGGHHHHLER YTLLLLLLSP PPDKAVIVVK PGQIVHTVTN GEEFFFHHFF WNACSSA-LA AGGHHHHIER FTLLLMMLSP PPDKAVVVVD EGQIVHQLIN GEEFFFHHFF WNACSSA-LT TGGHHHHLER YVAAAMMFDP PPEQAVVVVD PASIVGQVAH GEELLLHHFF WNACSSC-NA APPHHHHMER YVVVVRRLNP PPMKCVVVVD SGQVVGVTDY GEELLLHHFF WNACSSM-NA APPHHHHVER YVAAALLLDP PPGRGVLLLD GAQIVGRVEN AEELLLHHFF WNACAAA-YA APPHHHHVER YLPPPCCIYR RRNAATVVVD PSQVIHRLPY KEELLLHHSS WNTCSSC--F FGGDDDDKSR YLPPPCCIYR RRNAATVVVD PSQVIHRLPH KEELLLHHSS WNTCSSC--F FGGDDDDKSR YLPPPCCIYG GGNAATVIID PCQVIHRLPN REELLLHHSS WNACSSC--F FGGDDDDKSR YLPPPCCIYR RRNAATVVVD PCQVIHRLPH KEELLLHHSS WNTCSSC--Y YGGDDDDKAR YLPPPCCIYR RRNAATVVVD PCQVIHRLPN KEELLLHHSS WNTCSSC--F FGGDDDDKSR YLPPPCCIYR RRNAATVVVD PCQVIE---- ---------- ---------- ---------- ---------- ---AATVVVD PCQVIHRLPN KEELLLHHSS WNTCSSC--F FGGDDDDKSR YLPPPCCIYR RRNAATVVVD PCQVIHRLPN KEELLLHHSS WNTCSSC--F FGGDDDDKSR YLPPPCCIYR RRNAATVVVD PSQVIHRLPY KEELLLHHSS WNTCSSC--F FGGDDDDKSR YLPPPCCIYR RRNAATVVVD PCQVIHRLPN KEELLLHHSS WNTCSSC--F FGGDDDDKSR YLPPPCCIYR RRNAATVVVD PCQVIHRLPN KEELLLHHSS WNTCSSC--F FGGDDDDKSR YVTTTCCVYN NNGKATVLLD PSQVIHRLPH GKKLLLHHSS WNSCSSC--H HGGDDDDAKR ---------- ---------- ---------N NEELLLHHSS WNTCSSC--Y YGGDDDDKVR YLPPPCCIYR RRSKATVVVD PSQVIHRLPN NEELLLHHSS WNTCSSC--Y YGGDDDDKVR YVTTTAAVYA AAGKATVVVD PSKVIHRLPY GEELLLHHTT WNSCSSC--H HGGDDDDAER YVTTTAAVYA AAGKATVLLD PSKVIHRLPY GEELLLHHTT WNSCSSC--H HGGDDDDAQR ---------- ---------- ---------F GEELLLHHSS WNSCSSC--H HGGDDDDADR YVTTTAAVYT TTGKATVVVD PSSVIHRLPF GEELLLHHSS WNSCSSC--H HGGDDDDVDR YVTTTCCVYN NNGKGTVVVD PSQVIHRLPH GEELLLHHSS WNACSSC--H HGGDDDDASR FVTTTAAP-- ---GFTVVVN DCQVISRVDH GEEVVVHHTT WNACSSC--H HDDKKKKEKR FVTTTAAP-- ---GFTVVVN ECQIISRVDN GEEVVVHHTT WNACSSC--H HDDKKKKEKR ---------- ---------- ---------- ---------- ---------- ---------- YVVVVCCVQP PPNHATVVVD PCQVIHRTYS HEELLLHHSS WNTCSSCV-G GGGKKKKPTR YTVVVTTVQP PPNHSTVVVD PCQIVHRTFR GEELLLHHSS WNACSSCVES SSSKKKKPKR FSNNNWWLHG GGDDKNPMMV FGSVLKDGPV EKKEEELDSS PTPRLLK--- -GGKKKKQGG YVWWWTTLGV VVEEVTILLR AGQVINSVSG REEAAAHHGG FSA------- --------DR YVWWWTTLGA AAEEVTVAAN PGKVVNTLSG REEAAAHHSS FTD------- --------DR RRFIPGLLRR YIDDTNNPRE PKKIIKVIIE VVVKVVVSSG GGYYYVHCCG GDIISLNNEE RRYIPALLRR YIDDTDDKRR PAAAAKIVVE AAAGRRRTTG GGYYYVHCCG GDIISLGGPD RRFIPGLLRR YVDDTHHPTQ ARRHHKIIIE IIIAKKKTTG GGYYYVHCCG GEVVSLGGAD RRYIPGLLRR YIDDTDDPTK AKKHHKIIIE VVVKKKKTTG GGYYYIHCCG GDVVSLGGGD RRYIPGIIRR YIDDVEEPLK AKKHHKIIIE VVVAKKKTTG GGYYYIHCCG GEVVSLGGGD RRYVPGLLRR YIDDTDDPLK PFFAAKVIIE LLLERRRTTG GGYYYVHCCG GGVVTLNNAE RRYVPDIIRH TIDDTDDPTQ PKKVVKVIID LLLERRRTTG GGYYYVHCCG GDIISLSSPE RRYIPGIIRR HIDDTDDPRE PRRVVKVIIE LLLRRRRTTG GGYYYIHCCG GDVVSLSSPE NNKIPGLLMR YVDDVEEPRA PKKHHKVIIE IIIAKKKCCN NNVVVSHCCL LSMMVTGGDL DDKIPSIIIR YVDDVEEPRA PKKHHKVIIE IIIAKKKCCN NNLLLSHCCL LSMMISGGDP TTKMPCLLMR YVDDVDDPRA PKKHHKVIIE IIIAKKKCCG GGLLLSHCCL LSMMITGGDS TTKVPALLIR YVDDVEEPRA PKKHHKVIIE IIITKKKCCN NNLLLSHCCL LSMMVTGGDP TTKVPSLLIR YVDDVEEPRA PKKHHKVIIE IIIAKKKCCE EELLLSHCCL LSMMISGGDV ---------- ---------- ---------- IIIAKKKCCE EELLLSHCCL LSMMISGGDV TTKVPSLLIR YVDDVEEPRA PKKHHKVIIE IIIAKKKCCE EELLLSHCCL LSMMISGGDV TTKVPSLLIR YVDDVEEPRA PKKHHKVIIE IIIAKKKCCE EELLLSHCCL LSMMISGGDV NNKVPSFFIR YVDDVEEPRA PKKHHKVIIE IIIEKKKCCG GGLLLSHCCL LTMMITGGDP TTKVPSLL-- ---------- ---------- ---------- ---------- ---------- TTKVPSLLIR YVDDVEEPRA PKKHHKVIIE IIIAKKKCCE EELLLSHCCL LSMMISGGDV RRFIPSLLLR YVDDTDDPRT PSSHHKVVVE IIIENNNIIG GGLLLSHCCL LSMMICGGDK NNKIPCLLIR YVDDVDDPRA PRRHHKTVVE VVVWKKKCCG GGLLLSHCCL LCMMISGGDP NNKIPCLLIR YVDDVDDPRA PRRHHKTVVE VVVWKKKCCG GGLLLSHCCL LCMMISGGDP RRFIPSLLVR YVDDTNNPRS PSSHHKVVVD IIIQKKKTTG GGLLLSHCCL LSMMICGGDK RRFIPGIIVR YVDDTNNPRA PSSHHKVVVE IIITKKKTTG GGLLLSHCCL LSMMICGGDK RRYVPSLLIR YADDTNNPRA PSSYYKYVVD IIIEKKKTTG GGLLLAHCCL LSLLVCGGDE RRYVPSLLIR YADDTNNPRA PSSYYKYVVD IIIDKKKTTG GGLLLAHCCR R-LLVCGGDE RRFIPSLLLR YVDDTDDPRA PAAHHKVVVE IIIEKKKTTG GGLLLSHCCL LSMMICGGDK SSHIPCLLNR YINNVEE-RK IYYEEHTIIE LLLSLLLNN- --LLLSHCCL LDMMITGGEA SSHIPCLLNR YVNNVEE-RE IYYQQHTIIE LLLALLLNN- --LLLSHCCL LDMMITGGEA ---VRKLLSV GKFFV----- ---------- ---------- ---------- ---------- DDRVPCLLNR FVDDTDDPRA PKKAAKVIIE VVVKGGGAAD DDCCCTHCCL LNMMIIGGDA DDRVPSLLNF YIDDVDDPRK PEEVVKTIID VVVKSSSHHN NNVVVTHCCL LNMMIVGGDA PPQLLSLLDR YVTTSSSAWD KQQYYP---- LLLKFFFLLV VVLLLADYYQ QNKKQGNNES RRFWGGLLDR FIDDVDDPSN PKKHHKTIID VVVDSSSGGG GGVVVFFAAL LGIITLNNDD RRYWGGLLDK FVDDVDDPAR PVVSSKTIIT VVVKSSSGGG GGVVVLYAAL LGIITLNNNK EEGG--EPPP PGGGGGILML LHYYSSFFEP KEEEEEIGDD QQ-------- ---AADNLPN DDGGRREPPP PGGGGGIFLL LHDDTTFFEP REEEEEVGPP QQ-------- ---AADNLPS DDGGTTDAAA APPPGGIFIM MCEETTFFDV REEEEEIGPP QQ-------- ---HHDNLPR DDGGTTNPPP PPPPGGVFIM MCEETTFFEV REEEEEIGPP QQ-------- ---HHDNLPR DDGGTTDPPP PPPPGGIFIL LCEETTFFEI REEEEEMGEE QQ-------- ---HHDNLPR EEGG--KPPP PGGGGGIAML LAQQSSFFEP REEEEEVGPP QQ-------- ---AADHLGY EEGG--EPPP PGGGGGIFIL LHDDNNLLEV REEEEEIGDD QQ-------- ---HHDHLGY EEGG--DPPP PGGGGGVFVM MHEESSFFDP REEEEEVGPP QQ-------- ---AADHLGY LLQQGGNKKK KGGGSSFVLL LGEETTFFEV TEEEEEKGAA SS-------- ---GGDQPRH PPQQGGNKKK KGGGGGFVLL LGEETTFFEV TEEEEEKGEE AA-------- ---GGDQPRH SSKKGGNKKK KGGGGGFVLL LGEETTFFEV TEEEEEQGAA AA-------- ---GGDQPRH PPEEGGNKKK KGGGGGFVLL LGKKTTFFEV TEEEEEQGAA AA-------- ---GGDQPRH VVKKGGNKKK KGGGGGFVLL LGEETTFFEV TEEEEERGAA AA-------- ---GGDQPRH VVKKGGNKKK KGGGGGFVLL LGEETTFFEV TEEEEERGAA AA-------- ---GGDQPRH VVKKGGNKKK KGGGGGFVLL LGEETTFFEV TEEEEERGAA AA-------- ---GGDQPRH VVKKGGNKKK KGGGGGFVLL LGEETTFFEV TEEEEERGAA AA-------- ---GGDQPRH PPKKGGNKKK KGGGGGFVLL LGEETTFFEV TEEEEERGSS AA-------- ---GGDQPRH ---------- ---------- ---------- ---------- ---------- ---------- VVKKGGNKKK KDDDGGSLVL LP--RRLLEC ---------- ---------- ---------- KKEEGGNAAA AGGGNNGFLL LDSSEEFFNV RSSSSSNFPP II-------- ---EETENAW PPYYGGNKKK KGGGGGFVLL LGEETTFFEV NEEEEEAEAA AA-------- ---GGDQPRH PPCCGGNKKK KGGGGGFVLL LGEETTFFEV NEEEEEVESS AA-------- ---GGDQPRH KKDDGGNEEE EGGGNNGFLL LDSSDDFFNV REEEEEKHSS PP-------- ---GGDQPRH KKDDGGNEEE EGGGNNGFLL LDSSEEFFNV REEEEEKHSS PP-------- ---GGDQPRH EEEEGGNKKK KGGGNNGFLL LDSSDDFFNI REEEEEKHSS PP-------- ---GGDQPRH EEEEGGNKKK KGGGNNGLLL LDSSDDFFNI REEEEEKISS PP-------- ---GGHQPRH KKEEGGNAAA AGGGNNGFLL LDSSEEFFNV REEEEEKHSS PP-------- ---GGDQPRH AANNGGTSSS SGGGNNFLLL LGKKTTFFEP TPPPPPAKTT VV-------- ---NNDQPRR AADDGGSSSS SGGGNNFLLL LGKKTTFFEP TPPPPPAKVV VV-------- ---NNDQPRR ---------- ---------- ---------- ---------- ---------- ---------- AAEEGGNKKK KGGG--DFVE EDKKNNFFEL TSSSSSRRKK AA-------- ---GGDQPHF AAEEGGYKKK KGGG--DFIL LDSSDDFFNC TTTTTTKKKK AA-------- ---GGDQPYF SSLLSSVVVV VLLLNNGIQT TKHHEENNGL KEEEEEAFEE EE-------- ---QQSNG-R DDDDHHGRRR RTTTAALVEY YDDDGGEEYV YMMMMMPDDD MMGAVVVGDA DGGGGDLIRK KKDDHHGRRR RTTTAALVEY YNAAGGEEYV HIIIIIPGDD LLGAITTG-K DGGDDDLPRK LVVNN----T TTKLLLLEHL DD-YYGNIHW DDKRRRRIIH GENRMMA--- -----EEPPL MVVRR----C CCSLLLLECL EEGYYGNLHW DDKHHHHLLY GQHRMMV--- -----EEPPL MLLPP----Q QQVPPPPEDL AANYYGHLHW DDANNNNVVQ GAHQMMA--- -----EEPPA MLLPP----Q QQVPPPPEDL SSNYYGHLHW DDANNNNVVQ GAHQMMA--- -----EEPPA MLLPP----Q QQVPPPPEDL SSNYYGHIHW KKDNNNNVVQ GAHQMMA--- -----EEPPA LTTDD----M MMVPPPPDIL GGAYYGRLHW DDRHHHHLLQ GDHQLLV--- -----EEPPA LTTRR----M MMLGGGGDEL AAGYYGHLHW DDRHHHHLLQ GAYQMMA--- -----EEPPA MTTNN----M MMDPPPPQIL NNKYYGRLHW DDRHHHHLLQ GEHQMMV--- -----EEPPA MAANN----V VVPAAAAHVE --GYYGSIFW DDRIIIIIIQ T-DGLLI--- ----LEEFFL MAANN----V VVPAAAAHVE --GYYGSIHW DDRIIIIIIQ K-DGLLI--- ----LEEFFL MAANN----V VVPAAAADVE --GYYGSLHW DDRIIIIIIQ Q-DGLLI--- ----LEEFFL MAANN----V VVPAAAADVK --GYYGSLYW DDRIIIIVVQ Q-DGLLI--- ----LEEFFL MAANN----V VVPAAAADVE --GYYGSLYW DDHIIIIVVQ K-DGLLI--- ----LEEFFL MAANN----V VVPAAAADVE --GYYGSLYW DDRIIIIVVQ K-DGLLI--- ----LEEFFL MAANN----V VVPAAAADVE --GYYGSLYW DDRIIIIVVQ K-DGLLI--- ----LEEFFL MAANN----V VVPAAAADVE --GYYGSLYW DDRIIIIVVQ K-DGLLI--- ----LEEFFL MAANN----V VVPAAAADVE --GYYGKLHW DDRIIIIVVQ P-DGHHI--- ----LEEFFL ---------- ---------- ---------- ---------- ---------- ---------- -HHNN----L LLDYYYYPAS --SVVAGT-- ---------- ---------- ---------- FCCLL----F FFLMMMMCLT --SVVHVSCD NNMIIIIDDE Q-DQAAGNNP PPIILCCSSI MAAKK----A AAMEEEEEVQ --GYYGHLNW DDERRRRIIQ GEDGLLI--- ----LEEFFL MAAKK----A AAMEEEEDVQ --GYYGHLNW DDELLLLVVQ GKDGLLI--- ----LEEFFL MAATT----A AALQQQQHVA --GYYGRLTI QQRLLLLRRQ GNTGLLL--- ----LEEFFL MAAKK----A AALQQQQHVA --GYYGRLHY SSGIIIIKKQ GDKGLLL--- ----LEEFFL MAAKK----A AALQQQQHVA --GYYGSLHY SSGMMMMKKQ GETGLLL--- ----LEEFFL MAAKK----A AALQQQQHVA --GYYGSLHY SSGIIIIKKQ GPTGLLL--- ----LEEFFL MAAAA----A AALQQQQHVQ --GYYGRLHY DDGLLLLKKQ GSTGLLL--- ----LEEFFL MSSNN----H HHPAAAAHVG --GYYGNVHF EESYYYYLLQ PQLGAAL--- ----LEEFFL MSSNN----H HHPAAAAHVP --GYYGNVHF EETHHHHLLQ PMRGAAL--- ----LEEFFL -GGVV----T TTLKKKKCQP --PVVIKKRY ---------- ---------- ---------- MAAKK----L LLPTTTTDCD RRTYYGCLNY RRELLLLFFQ GDDGLLT--- ----LEEFFL MAANN----K KKNVVVVDLE MMSYYGCLNY KKTLLLLYYQ GSDGIIT--- ----LEEFFL SEEII----M MMSFFFFLKK GGPKKPQVAV LL-------- ---------- ---------- MGGSSNNNYM MMLQQQQDAE MMKFFGNIVW DDTPPPPKKK PGP------- ----LEEFFP LGGNNNNNYM MMLAAAADPE MMKFFGNVVW DDTPPPPKKK PGP------- ----LEECCA LHHDKGIINN NVVVSLDDLL SSIWWLFYY- DKKWAAEKKK KKVIEPPLEE G-NLLELPFF LHHDKGVVNN NVVVNTDDLL SSIWWLFYY- DKKWAAERRR RRVIDEEFEE G-PLLPLDFF AHHDRGVVGG GVVVDTNNLL EGIWWTWRR- GKKFVVKKKK KKTATPPATT ADELLPLGFF AHHDRGVVGG GVVVDTNNLL EAIWWTWRR- GKKFAAEKKK KKTATPPAPP KEKLLPLGFF AHHDKGCCGG GVVVDTNNLL QGIFFTWQQK DTTFAAKKKK KKTITDDADD ADDLLDLGFF AHHDKGVVNN NVVVSLDDLL SSIWWTYRR- KKKWVVRKKK KKVIEPPADD PDQLLPLGFF AHHDKGMMNN NVVVSLDDLL SAIWWLYRR- NSSWLLKKKK KKVIDPPASS EDQLLPLPFF AHHDRGVVGG GVVVSLDDLL SAVWWLHRR- NSSWIIRKKK KKVIEPPAEE PDQLLPLDFF LHHDAGVVGG GAAASSIIQQ RFKNNEG--- ---------- ---TWVVIQQ VPSKKVGMLL LHHDAGVVGG GAAASSIIQQ RFKNNEG--- ---------- ---TWVVIQQ VPSKKVGMLL LHHNAGVVGG GAAASSIIQQ RFKNNQG--- ---------- ---TWVVIQQ VPPKKVGMLL LHHNAGVVGG GAAASSIIQQ RFKNNEG--- ---------- ---TWAAIQQ VPPKKVGMLL LHHNAGVVGG GAAASSIIQQ RFKNNEG--- ---------- ---TWVVIQQ VPPKKVGLLL LHHNAGVVGG GAAASSIIQQ RFKNNEG--- ---------- ---TWVVIQQ VPPKKVGLLL LHHNAGVVGG GAAASSIIQQ RFKNNEG--- ---------- ---TWVVIQQ VPPKKVGLLL LHHNAGVVGG GAAASSIIQQ RFKNNEG--- ---------- ---TWVVIQQ VPPKKVGLLL LHHDAGVVGG GAAASSIIQQ RFKNNEG--- ---------- ---TWVVIEE VPPKKVGMLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IHHWIDDDVV VEEESFGGRR GGDPPDY--- ---------- ---AVLLLDD LYYAAVKGVV LHHDAGVVGG GAAASSVVFF RFKEEKG--- ---------- ---KWAAIKK VPSKKVGALL LHHNAGVVGG GAAASSIIFF RFKEEKG--- ---------- ---KWAAIQQ VPSKKVGPMM LHHDKGVVGG GAAASSMMII RFKTTQG--- ---------- ---SWHHIPP VKPLLVNILL LHHDKGVVGG GAAATSMMII RFKTTQG--- ---------- ---SWHHISS VEPLLVNFLL LHHDKGVVGG GAAASSMMII RFKNNSD--- ---------- ---TWYYISS VKPLLVNILL LHHDKGVVGG GAAASSMMII RFKNNSE--- ---------- ---TWHHISS VKPLLVNILL LHHDKGVVGG GAAATSMMVV RFKTTAG--- ---------- ---SWHHISS IKPLLVNILL LHHESAVVGG GAAAGSIIFF RIPVVENSS- -------TTT TT-THAAAFF IPSKKVGALL LHHESAVVGG GAAAGSIIFF RIPDDENPP- -------KKK KK-VQAAATT IPSKKVNALL ---------- ---------- ---------- ---------- ---------- ---------- LHHNEGVVGG GAAAXXXXXX XX-------- ---------- ---------- -----GNEII LHHNKGVVGG GAAANAVVFF HFKKKSSDD- -------EEE EEFEAKKIPP GKLVVTSVAA ---------- ---------- ---------- ---------- ---------- ---------- PWWGAASSTT TAAATSLLWW LIEDDDG--- ---------- --------EE WQAKKVDGNN AWWGHCTTSS SAAATSLLWW LIEDDGG--- ---------- --------EE WQAKKVDGEE FKKKKPPPPL TDDIDDDLDD KLGIIEVVVQ YDDISNPPKK KLTKKKKGGG GGGIIFHHHP FKKKKPPPPL TDDIDDDLDD RLGLLELLLQ YDDITNPPQQ QLARRKKGGG GGGLLYHHHP FGGGGPPPPL TDDIDDDLDD RLGTTEMMMQ YDDVSDPPNN NLASSRRGGG GGGIIARRHP FGGGGPPPPL TDDIDDDMDD RLGTTEMMMQ YDDVSDPPKK KLASSHHGGG GGGIIARRHP FGGGGPPPPL TDDIDDDLDD KLGLLEMMMQ YDDVSDPPNN NLTKKEEGGG GGGIIVKKHP FKKKKPPPPL TDDIDDDMDD RLGTTDLLLQ YDDVSDPPEE ELTKKRRGGG GGGIIVSSHP FKKKKPPPPL TDDINNNVDD RLGTTELLLQ YDDVSDPPNN NLTKKQQGGG GGGIIVRRHP FGGGGPPPPL TDDINNNLDD RLGTTELLLQ YDDVSDPPNN NHTSSRRGGG GGGIIVRRHP LPPPPPPPGL TDDILLLLDD RLLHHDIIIQ YDDISNPPKK KLTQQFFGGG GGGSSIVVSV LPPPPPPPGL TDDILLLLDD RLLHHDIIIQ YDDISNPPKK KLTQQFFGGG GGGSSIVVSV LPPPPPPPGL TDDILLLLDD RLLHHDLLLQ YDDISDPPRR RLTQQFFGGG GGGSSIVVPV LPPPPPPPGL TDDILLLLDD HLLHHDIIIQ YDDVSDPPRR RLTQQFFGGG GGGSSIVVPV LPPPPPPPGL TDDILLLLDD RLLHHDLLLQ YDDISDPPRR RLTQQFFGGG GGGSSIVVPV LPPPPPPPGL TDDILLLLDD RLLHHDLLLQ YDDISDPPRR RL-------- ---------- LPPPPPPPGL T--------- ---------- ---------- ---------- ---------- LPPPPPPPGL TDDILLLLDD RLLHHDLLLQ YDDISDPPRR RLTQQFFGGG GGGSSIVVPV LPPPPPPPGL TDDILLLLDD RLLHHDMMMQ YDDISDPPRR RLVQQFFGGG GGGSSIVVPV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVVVSSSNE PPPAWWWFSD LI-------- ---------- ---------- ---------- LPPPPPPPGL TDDILLLLDD RLLHHDIIIQ YDDITDPPNN NLVQQFFGGG GGGSSILLPV MPPPPPPPGL TDDILLLLDD RLLHHDIIIQ YDDITDTTNN NLVQQFFGGG GGGSSIQQPV LPPPPPPPGL TDDFLLLLDD RLLHHDIIIQ YNNIEDLLNN NLTQQWWGGG GGGLLIQQPV LPPPPPPPGL TDDFLLLLDD RLLHHDIIIQ YNNIEDVVNN NLTQQWWGGG GGGLLIQQPV LPPPPPPPGL TDDFLLLLDD RLLHHDIIIQ YNNIEDPPNN NLTQQWWGGG GGGLLLQQPV LPPPPPPPGL TDDFLLLLDD RILHHDIIIQ YNNIEDPPNN NLTQQWWGGG GGGLLLQQPV LPPPPPPPGL TDDFVVVLDD RLLHHDIIIQ YNNIEDPPKK KLAQQWWGGG GGGLLLQQEV LPPPPPPPAL TDDILLLMDD RLLHHDIIIQ YDDISDPPKK KLNQQYYGGG GGGSSVHHNV LPPPPPPPAL TDDILLLMDD RLLHHDIIIQ YDDISDPPNN NLNQQFFGGG GGGSSIHHTV ---------- ---------- ---------- ---------- ---------- ---------- IEEEEGGGGM TDDILLLLDD RLRHHDVVVQ YDDISDRRNN NLTQQFFGGG GGGAAIQQPR AEEEEGGGGM SDDIIIILDD RLRHHDVVVQ YDDITDPPNN NLTQQFFGGG GGGAAICCPN ---------- ---------- ---------- ---------- ---------- ---------- NPPPPIIIPL VDDISSSADD QLMDDKTTTL FDDISDPPKK KQIEEVVDDR RRRQQVNN-- EPPPPVVVPL VDDISSSNDD SLMDDKTTTL FDDISDPPHH HQVEETTGGA AAAQQVNN-- ---------- -------GGG HLTAQQMMEE SDDRRRVTTT SLLYSSTTWD DQFYYEELLL ---------- -------GGG AATAQQMMSS SDDRRRVTTT SLLYSSSSWN NQFYY--LLL ---------- -------GGG RFAGQQMMEE SDDRRRVTTT SLLYSSTTWD DQFYYDDVVV ---------- -------GGG KFAGQQMMEE SDDRRRVTTT SLLYSSTTWD DQFYYDDVVV ---------- -------GGG KFGGQQMMEE SDDKRRVTTT SLLYSSTTWD DQFYYGGRRR G--------- -------NNN GLNGQQMMEE SDDRRRVTTT SLLYGGAAVD DQFYYEEIII ---------- -------SSS ALNGQQMMEE SDDRRRVTTT SLLYRRAAWD DQFYYDDIII ---------- -------SSS GLNGQQMMEE SDDRRRVSSS SLLYAASSWD DQFYYVVIII QVVLEE-DQQ EQPEELVGGG KIPGQQMMQQ SDDKRRLTTT SLLYSSDDWD DQFYYPPLLL QVVLEE-DQQ EQPEELVGGG KVPGQQMMQQ SDDKRRLTTT SLLYSSAAWD DQFYYPPLLL QVVLEE-DQQ EQPEELVGGG KVPGQQMMQQ SDDKRRLTTT SLLYSSAAWD DQFYYPPLLL QVVLDD-DQQ EQPEELVGGG KVAGQQMMQQ SDDKRRLTTT SLLYSSAAWD DQFYYPPLLL QVVLEE-DQQ EQPEELVGGG KVAGQQMMQQ SDDKRRLTTT SLLYSSAAWD DQFYYPPLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QVVLEE-DEE EQPEELVGGG KVAGQQMMQQ SDDKRRLTTT SLLYSSAAWD DQFYYPPLLL QVVLEE-DQQ EQPEELVGGG KVPGQQMMQQ SDDKRRITTT SLLYSSDDWD DQFYYPPLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TVVLEE-DKK DQPDDVIGGG KVPGQQMMQQ SDDKRRLTTT SLLYSSKKWD DQFYYPPMMM TVVLEE-DKK EQPDDVTGGG KIPGQQMMQQ SDDKRRITTT SLLYSSIIWD DQFYYPPLLL AAAIGG-EDD GQSDDPEGGG QLRGQQMMQQ TDDKRRLTTT SLLFSSAAWD DQFYYPPLLL VAAVKK-DDD GQSDDPEGGG KLRGQQMMQQ SDDKRRLTTT SLLFSSAAWD DQFYYPPLLL KAAVGG-EDD GQFDDPQGGG KLRGQQMMQQ SDDKRRLTTT SLLFSSAAWD DQFYYPPLLL KAAVGG-EDD GQFEEPQGGG KLRGQQMMQQ SDDKRRLTTT SLLFSSAAWV VSFYYPPIII VYYVTT-EDD DQYSSPQGGG HLRGQQMMQQ SDDKRRITTT SLLFSSRRWD DQFYYQQLLL KVVLEE-GEE KPIEELYGGG RIEGQQMMQQ SDDKRRLTTT SLLYKKKKWD DQFYYPPHHH KVVLEE-EDD HEIPPLYGGG RIEGQQMMQQ SDDKRRLSSS SLLYKKKKWD DQFYYPPNNN ---------- ---------- ---GAAKKQQ SDDKRRLTTT SFFYSSTTWD DQFYYPPVVV RVVLNN-DPP EAPEEVFGGG RLLGQQMMQQ SDDRRRLSSS SLLFSSPPWD DQFYYPPMMM VIIVKKEDKK ERPPPRYGGG RLEGQQMMQQ SDDKRRLSSS SLLYSSPPWD DQFYYPPMMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMSS SDDKRRVSSS SLLLAANNWD D--------- ---------- ---------- ------MMSS SDDQRRLTTT SLLLAANNWD D--------- KWMMVVVLLL LNN------P PGGGLLLLED KKVVDEE-AR SHHVVVRLGS SSSCC----- RWMMAAAVVV VNN------P PGGGLLLLEE KKVVDRR-AR AHHVVVRLGS STSCC----- PAQQVVVAAA AHH------P PGGGLLLLTA DDVVEDD-YR AHHIIIRLGS STSCCVVKR- PVEEVVVAAA ANN------G GGGGLLLLED KKVVSDD-YR AHHIIIRLGS STSCCVV--- GAMMVVVAAA ANN------E EGGGLLLLTD KKVVDAA-YR SHHIIIRLGS STSCCVV--- DWMMVVVLLL LDD------P PGGGIIIIED PPLLEKK-HR PHHVVVRLGS SSSCC----- KWMMVVVVVV VDD------P PGGGMMMMQD PPVVDEE-QR VHHIIIRLGS SSSCC----- RWIIAAAAAA AEE------P PGGGLLLLSD PPTTEDD-LR PHHIIIRLGS SSSCC----- IEGGSSSMMM MLLDDDDDTV VGGGLLLLKN PPVVDKKPAL AHHLLLRYGS SSIII----- IEGGSSSMMM MLLDDDDDTA AGGGLLLLKN PPVVDKKPAL AHHLLLRYGS SSIII----- IEGGSSSMMM MLLDDDDDTV VGGGLLLLKN PPVVDKKPAL AHHLLLRYGS SSILL----- IEGGSSSMMM MLLDDDDDTV VGGGLLLLTN PPVVDKKPAL AHHLLLRYGS SSILL----- IEGGSSSMMM MLLDDDDDTV VGGGLLLLKN PPVVDKKPAL AHHLLLRYGS SSIII----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IEGGSSSMMM MLLDDDDDTV VGGGLLLLKN PPVVDKKPAL AHHLLLRYGS SSIII----- IEGGSSSMMM MLLDDDDDTV VGGGLLLLKN PPVVDKKPAL AHHIIIRYGT TSILL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IEGGSSSMMM MLLDDDDDTE EGGGLLLLKN PPVVDKKPVL AHHLLLRYGS SSIVV----- LEGGAAAMMM MLLDDDDDTK KGGGLLLLKN PPVVDKKPVL AHHIIIRYGT TSIII----- VKGGSSSIII ILLDDDDDTE EGGGLLLLKN PPVVDAAPAL AHHMMMRYGT TSIII----- VQGGSSSIII ILLDDDDDTE EGGGLLLLKN PPVVDAAPSL AHHMMMRYGT TSIII----- MKGGSSSIII IIIDDDDDTE EGGGLLLLSN PPVVDDDPAL AHHMMMRYGT TSIII----- MKGGSSSIII IIIDDDDDTE EGGGLLLLTN PPVVDDDPSL AHHMMMRYGT TSIII----- VKGGSSSMMM MLLDDDDDTE EGGGLLLLSN PPVVDAAPSL AHHMMMRYGT TSIII----- VSGGAAAMMM MVVNNDDDPE EGKKMMMMEN RRIIDKKEYL AHHMMMRYGT TSIII----- VSGGAAAMMM MLLDDDDDPI IGHHMMMMVN KKIIDKKPYL AHHMMMRYGT TSIII----- VEGGSSSMMM MLLDDDDDTE EGGGLLLLTN KKVVDKKPCL AHHIIIRFGT TSIAA----- VAGGGGGIII IVVDDDDDVE EGGGMMMMKN EEVVDGGPGL PHHMMMR--- ---------- VQGGGGGIII IVVDDDDDTV VGGGIIIISN EEVVDNNPSL PHHMMMRYGT TSILLAA--- ---------- ---------- ---------- ---------- ---------- ---------- -KGGKKKDDD DAALLAAAYN NDGGKKKKEV EEVVDEEG-R AHHMMMRFSY YS-------- -KGGKKKDDD DEELLLLLYY YDGGKKKKEK EEIIDAAK-R PHHMMMRFRY YAPGGRRLVQ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QRRVEEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNNNSSKQQ PSSEAAPPCC CRAVVTTGGR RADGAAAMMS LPRTTTLLSL LTPPPVVRRY gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------M gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQQEEEAAAW WWTTFFFFSS QQQVVLLASE KKKKKKSPGL LLEEEISSAA KKVPQAVQQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAAGGGRRSA AAPPTTTTPP NNNNNRRTTN LLLAAAPPRV VVLLLTRLVV YYINPRLPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MI IPKPTFFSSS PPMAMKKAAP PEEDLAYYYV ---------- ---------- ---------M MKKPTFFTTT PPDAMRRAAP PEEDIAYYYV ---------- ---------- ---------- -SRPTFFSSS PPLAMQQAAP PEEEFAYYYT ---------- ---------- ---------- -TRPTFFSSS PPLAMEEAAP PEENFAYYYT ---------- ---------- ---------- -TRPTFFSSS AALAMEEGGP PEEKLAFFFT ---------- ---------- ---------M MTKPSFFSSS PPLAAKKAAP PEETIAYYYV ---------- ---------- ---------M MTRPTFFSSS PPMAVKKAAP PEEKLAYYYV ---------- ---------- ---------M MSRPTFFSSS PPMAMQQAAP PEERLGYYYV ---------- ---------- -------MTC CK-PGYYPPP LLAMK--GGP PEEEIVYYYL ---------- ---------- ---------- ---------- ----M--GGP PEEEIVYYYL AHHWWPPGKK HHGAAAAVAP AARLP--HTC CK-PGYYPPP LLAMK--GGP PEEEIVYYYL ---------- ---------- ---------- ---------- ---MK--GGP PEEEIIYYYL ---------- ---------- -------MTC CN-PGYYPPP LLAMK--GGP PEEEIVYYYL -----AERAA EEGAFFFTSV AAQRPAATTC CN-PGYYPPP LLAMK--GGP PEEEIVYYYL ---------- ---------- -------MTC CN-PGYYPPP LLAMK--GG- ---------- ---------- ---------- -------MTC CN-PGYYPPP LLAMK--GGP PEEEIVYYYL -MMGGGKEEE PPGHTTTAWF LLSLWEETTC CD-PGYYPPP QQAMK--GGP PEEEIVYYYL LKKNNQGCLL GGFDQQQTEL HHTTLFFSTC CN-PGYYPPP LLAMK--GGP PEEEIVYYYL ---------- ---------- -------MTC CN-PGYYPPP LLAMK--GGP PEEEIVYYYL PPPHHRHSLL VVLQHHHIGA AAATAAANKC CHAPGYYPPP LLAMEKKGGP PEEKLVYYYV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AC CS-PGYYPPP LLAMK--GGP PEEEIVYYYL ---------- --------TV LLDVVEEK-N NCKPGYYPPP IISMS--GGP PEESLIYYYV ---------- --------TV LLQVVEEVNQ QCKPGYYPPP LLAMS--GGP PEETLIYYYV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R RLVPGYYPPP LLAMS--GGP PEEKLIYYYV ---------- ---------- ---MAAANAC CGAPGYYPPP LLAMEKKGGP PEEKLLYYYV ---------- ---------- ----MPPCLC CG-PGYYPPP AAAIK--GGP PEEEVLFFFV ---------- ---------- ----M--CLC CG-PGYYPPP AAAIK--GGP PEEEVLFFFV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------ME EKKPGYYPPP LLAVRNNGGP PEEKLLYYYV ---------- ---------- ---------- ---------- ---MRSSGGP PEEKLLYYYT ---------- ---------- ---------- ---PGLL--- --ILISSLLD DRRFLYFFFS -----KRREE FFG------- ---AA--LML LFADETTSSS PPMPKIITTG GEEEFVYYYV -----KRFII VVSGPPPSFA LLRVSLLLLA AAVDETTSSS PPMKKIITTG GEEDYVYYYV ACYTGINAAA DDDFFIAAVP PSEEEETYKK VVHHHIIDEE EGWAACCSSA AAL---N--K AAYVGVNPPP DDDFFLAAVP PSPPPPTYKK IIYYYIIDEE EGWAACCSSA AAY---N--K LLSPD--PPP DDDAALAAVP PSSSSSTYKK VVHHHTTDEE EGWAACCSSS SSL---LGGH LLSPD--PPP DDDAALAAVP PSPPPPTYQQ VVHHHKKDEE EGWAACCSSA AAL---LGGH LMSPD--PPP DDDGGLAAVP PSEEEEKFQQ VVHHHKKDEE EGWAACCSSA AAL---LGGH AMDPE--PPP DDDAAIAAVP PSPPPPRYSS VVGGGAADEE EGWAACCSSC CCL---NPPH VRNPMG-PPP DDDAAMCCVS SSSSSSTFQQ VVGGGTTGEE EGWAACCSSM MML---NPPH ALDPG--PPP DDDAALGGLP PSGGGGTYQQ VVGGGAADEE EGWAACCSSA AAL---YPPH PCYRNTEPPP DDDYYLAAVP PSPPPPQYQQ IIHHHLLDEE EGWTTCCSSC CC-----GGD PCYRNIEPPP DDDYYLAAVP PSPPPPHYQQ IIHHHLLDEE EGWTTCCSSC CC-----GGD PCYGNIEPPP DDDYYLAAIP PSPPPPQYQQ IIHHHLLDEE EGWAACCSSC CC-----GGD PCYRNIEPPP DDDYYLAAVP PSPPPPQYQQ IIHHHLLDEE EGWTTCCSSC CC-----GGD PCYRNTEPPP DDDYYLAAVP PSPPPPQYQQ IIHHHLLDEE EGWTTCCSSC CC-----GGD PCYRNTEPPP DDDYYLAAVP PSPPPPQYQQ IIEEE----- ---------- ---------- -----TEPPP DDDYYLAAVP PSPPPPQYQQ IIHHHLLDEE EGWTTCCSSC CC-----GGD PCYRNTEPPP DDDYYLAAVP PSPPPPQYQQ IIHHHLLDEE EGWTTCCSSC CC-----GGD PCYRNTEPPP DDDYYLAAVP PSPPPPQYQQ IIHHHLLDEE EGWTTCCSSC CC-----GGD PCYRNTEPPP DDDYYLAAVP PSPPPPQYQQ IIHHHLLDEE EGWTTCCSSC CC-----GGD PCYRNTEPPP DDDYYLAAVP PSPPPPQYQQ IIHHHLLDEE EGWTTCCSSC CC-----GGD TCYNGINLLL DDDYYLAALP PSPPPPTYQQ IIHHHIIDKK KGWSSCCSSC CC-----GGD ---------- ---------- ---------- -----TTDEE EGWTTCCSSC CC-----GGD PCYRSINPPP DDDYYLAAVP PSPPPPSYQQ IIHHHVVDEE EGWTTCCSSC CC-----GGD TAYAGIEPPP DDDYYLAAVP PSPPPPTYKK IIHHHVVDEE EGWSSCCSSC CC-----GGD TAYAGIEPPP DDDYYLAALP PSPPPPTYKK IIHHHVVDEE EGWSSCCSSC CC-----GGD ---------- ---------- ---------- -----VVDEE EGWSSCCSSC CC-----GGD TAYTGIDPPP DDDYYLAAVP PSPPPPSYSS IIHHHVVDEE EGWSSCCSSC CC-----GGD TCYNGINPPP DDDYYLGGVP PSPPPPTYQQ IIHHHVVDEE EGWAACCSSC CC-----GGD TA---ADPPP DDDAAIFFVP PSDDDDTFQQ IISSSIIDEE EGWAACCSSC CC-----DDK TA---RDPPP DDDAAIFFVP PSEEEETFQQ IISSSIIDEE EGWAACCSSC CC-----DDK ---------- ---------- ---------- ---------- ---------- ---------- VCQPNEEGGG DDDYYLAAVP PSPPPPTYQQ IIHHHKKNEE EGWTTCCSSC CCHVVV-GGK VTQPNEPGGG DDDYYLSSVP PSPPPPTYQQ VVHHHKKDEE EGWAACCSSC CCYVVVESSK NWHGDQYIII TTTDDRKKMG GVFFFFLGSS LLKKKLLDKK KQPPPRRIIK KK-----GGK WTGVEGDQQQ DDDKKLVVLP PSAAAATRQQ IINNN--NEE EGFAA----- ---------- WTGAEGDQQQ DDDKKLVVAP PSPPPPQYKK VVNNN--NEE EDFDD----- ---------- NEERLLGLSS RIIIDTTPPN EPKKKIKVII IPEEKKSGGR LLHTTTHHPA AIIN---EEE FEERLLALSS RIIVDTTPPD RPAAAAKIVV VPEVGGTGGK YYHTTTHHPA AIIG---DDE FEERLLGLSS RIVIDTTPPH QARRRHKIII IPDEAATGGR PPHTTTHHPG GIVGGGGDDD FEERLLGLSS RIIIDTTPPD KAKKKHKIII IPEEKKTGGR PPHTTTHHPG GIVGGGGDDN FEERLLGISS RIIVDVV--E KAKKKHKIII IPEEAATGGR PPHTTTHHPG GIVGGGGDDD HEERLLGLSS RIILDTTPPD KPFFFAKVII IPETEETGGR PPHTTTHHPG GIVN---EEK HEERLLDISS HIILDTTPPD QPKKKVKVII IPNEEETGGR PPHTTTHHPG GIIS---EEE HEERLLGISS RIIVDTTPPD EPRRRVKVII IPEERRTGGR PPHTTTHHPG GVVS---EED TSSNLLGLSS RIVVDVVSSE APKKKHKVII IASEAACNNN TTHTTTHHAG GEMG---LLN TSSDLLSISS RIVVDVVSSE APKKKHKVII IPNEAACNNN LLHTTTHHAG GEMG---PPN TSSTLLCLSS RIVVDVVSSD APKKKHKVII IAEDAACGGY VVHTTTHHAG GEMG---SSN TAATLLALSS RIVVDVVTTE APKKKHKVII IPKDTTCNNF FFHTTTHHPG GEMG---PPN TSSTLLSLSS RIVVDVVSSE APKKKHKVII IPEDAACEEF LLHTTTHHAG GEMG---VVN ---------- ---------- ---------- -PKDAACEEF LLHTTTHHAG GEMG---VVN TSSTLLSLSS RIVVDVVSSE APKKKHKVII IPKDAACEEF LLHTTTHHAG GEMG---VVN TSSTLLSLSS RIVVDVVSSE APKKKHKVII IPKDAACEEF LLHTTTHHAG GEMG---VVN TSSNLLSFSS RIVVDVVTTE APKKKHKVII IAKDEECGGT PPHTTTHHPG GEMG---PPN TSSTLLSL-- ---------- ---------- ---------- ---------- ---------- TSSTLLSLSS RIVVDVVSSE APKKKHKVII IPKDAACEEF LLHTTTHHAG GEMG---VVN SKKRLLSLGG RVVVDTTTTD TPSSSHKVVV VSEDEEIGGF PPHTTTHHAG GDMG---KKN SVVNLLCLSS RIVVDVVTTD APRRRHKTVV VPYEWWCGGN LLHTTTHHGG GEMG---PPN SVVNLLCLSS RIVVDVVSSD APRRRHKTVV VPYEWWCGGN PPHTTTHHGG GEMG---PPN SEERLLSLGG RIVIDTTTTN SPSSSHKVVV VPADQQTGGY PPHTTTHHAG GEMG---KKN SQQRLLGIGG RVVIDTTTTN APSSSHKVVV VPEDTTTGGY PPHTTTHHAG GEMG---KKN SDDRLLSLGG RIAIDTTEEN APSSSYKYVV VPKEEETGGY PPHTTTHHAG GELG---EEN SDDRLLSLGG RIAIDTTEEN APSSSYKYVV VPKEDDTGGF PPHTTTHHTG GELG---EEN SSSRLLSLGG RVVVDTTKKD APAAAHKVVV VAEDEETGGF PPHTTTHHAG GEMG---KKN TKKSLLCLDD RIIINVVNNE KIYYYEHTII IPSKSSN--F PPHTTTHHAG GNMG---AAT TKKSLLCLDD RIVINVVNNE EIYYYQHTII IPSKAAN--F PPHTTTHHAG GNMG---AAS ----MMKLGG VEKVFVVGG- ---------- ---------- ---------- ---------- VTTDLLCLDD RIVIDTTTTD APKKKAKVII IG-DKKADDA PPHTTTHHPG GNMG---AAN VKKDLLSLDD FIILDVVTTD KPEEEVKTII IG-DKKHNNA PPHTTTHHAG GNMG---AAY VGGPMMSLKK RLVTTSSYYS DKQQQYP--- ---DKKLVVI SSHTTTDDPT TAKN---SSV -DDRFFGLNN RIIFDVVSSD NPKKKHKTII IT-FDDGGGG PPHTTTFFPS SMIN---DDG -DDRLLGLSS KIVFDVVSSD RPVVVSKTII ID-FKKGGGG PPHTTTYYPR RMIN---KKG EGPPPGGGII ILMMDHYSSS FFLLGGEIID DDRRRGGDD- ---LLAYDFW L-PPPPVSEE EGPPPGGGII IFLLDHDTTT FFIIGGEVVY YYRRRGGPP- ---FFAYDFW L-PPPPVTEE DGAAAPPGII IFIIDCETTT FFLLGGEIID DDRRRGGPP- ---KKHYDFW L-PPPPYSEE NGPPPPPGVV VFIIDCETTT FFLLGGEIID DDRRRGGPP- ---LLHYDFW L-PPPPYTEE DGPPPPPGII IFIIDCETTT FFLLGGEMMD DDRRRGGEE- ---KKHYDFW L-PPPPYSEE KGPPPGGGII IAMMDAQSSS FFLLGGEVVE EERRRGGPP- ---FFAYDGW L-GGGGTTEE EGPPPGGGII IFIIDHDNNN LLLLGGEIID DDRRRGGDD- ---LLHYDFW L-GGGGTTEE DGPPPGGGVV VFVVDHESSS FFLLGGEVVE EERRRGGPP- ---LLAYDFW L-GGGGTTEE NGKKKGGSFF FVLLDGETTT FFKKGGEKKP PPGGGGGAA- ---MMGYDFY P-RRRRVSEE NGKKKGGGFF FVLLDGETTT FFKKGGEKKP PPGGGGGEE- ---MMGYDFY P-RRRRISEE NGKKKGGGFF FVLLDGETTT FFKKGGEQQP PPGGGGGAA- ---MMGYDFY P-RRRRVSEE NGKKKGGGFF FVLLDGKTTT FFKKGGEQQP PPGGGGGAA- ---LLGYDFY P-RRRRVSEE NGKKKGGGFF FVLLDGETTT FFKKGGERRP PPGGGGGAA- ---SSGYDFY P-RRRRVSEE NGKKKGGGFF FVLLDGETTT FFKKGGERRP PPGGGGGAA- ---LLGYDFY P-RRRRVSEE NGKKKGGGFF FVLLDGETTT FFKKGGERRP PPGGGGGAA- ---LLGYDFY P-RRRRVSEE NGKKKGGGFF FVLLDGETTT FFKKGGERRP PPGGGGGAA- ---LLGYDFY P-RRRRVSEE NGKKKGGGFF FVLLDGETTT FFKKGGERRP PPGGGGGSS- ---MMGYDFY P-RRRRVSEE ---------- ---------- ---------- ---------- ---------- ---------- NGKKKDDGSS SLVVLP-RRR LLSSGG---- ---------- ---------- --------II NAAAAGGNGG GFLLLDSEEE FFKKGGSNNR RRLLLFFPP- ---KKERTHY NYAAAALSII NGKKKGGGFF FVLLDGETTT FFKKGGEAAE EEGGGEEAA- ---FFGYDFY P-RRRRVSEE NGKKKGGGFF FVLLDGETTT FFKKGGEVVE EEGGGEESS- ---FFGYDFY P-RRRRVSEE NAEEEGGNGG GFLLLDSDDD FFKKGGEKKP PPGGGHHSS- ---FFGYDFY P-RRRRTSSS NAEEEGGNGG GFLLLDSEEE FFKKGGEKKP PPGGGHHSS- ---FFGYDFY P-RRRRTSSS NAKKKGGNGG GFLLLDSDDD FFKKNNEKKP PPGGGHHSS- ---FFGYDFY P-RRRRTSSS NAKKKGGNGG GLLLLDSDDD FFKKNNEKKP PPDDDIISS- ---YYGYHFY P-RRRRTSSS NAAAAGGNGG GFLLLDSEEE FFKKGGEKKP PPGGGHHSS- ---FFGYDYY P-RRRRTSSS TPSSSGGNFF FLLLDGKTTT FFKKGGPAAD DDEEEKKTT- ---FFNYDFY P-RRRRVSEE SPSSSGGNFF FLLLDGKTTT FFKKGGPAAD DDGGGKKVV- ---FFNYDFY P-RRRRISEE ---------- ---------- ---------- ---------- ---------- -------SLL NAKKKGG-DD DFVVFDKNNN FFVVGGSRRG GGDDDRRKK- ---CCGYDYY P-HHHHVAEE YAKKKGG-DD DFIIFDSDDD FFIIGGTKKG GGDDDKKKK- ---CCGYDFY P-YYYYVSEE VPVVVLLNGG GIQQSKHEEE NNSSAAEAAS SSQQQFFEE- ---LLQLSNN G-----KSRR GGRRRTTALL LVEENDDGGG EEAATTMPPT TTAAADDDDA DDAYYGYDIA I-RRRRVTSS GGRRRTTALL LVEETNAGGG EEAATTIPPT TTDDDGGDDK --AYYDYDVA P-RRRRLTSS EWVPPN---T TGGLLKEHLL KKD-RRNRRI IHWLLKKRHS LTEENNNNRL -----EEELP EWVPPR---C CGGFFSECLL KKEGAANKKL LHWLLKKHYA IDQQHHHHRL -----EEEVP EWLPPP---Q QGGIIVEDLL LLANKKHRRL LHWLLAANQT IDAAHHHHQL -----EEEVP EWLPPP---Q QGGIIVEDLL LLSNKKHRRL LHWLLAANQT IDAAHHHHQL -----EEEVP EWLPPP---Q QGGIIVEDLL LLSNKKHKKI IHWLLDDNQT IDAAHHHHQL -----EEEIP EWTPPD---M MGGLLVDILL LLGARRRRRL LHWLLRRHQE IDDDHHHHQF -----EEELP EWTPPR---M MGGVVLDELL LLAGKKHRRL LHWLLRRHQT LDAAYYYYQL -----EEELP EWTPPN---M MGGLLDQILL LLNKGGRRRL LHWLLRRHQA LDEEHHHHQL -----EEELP EWAPPN---V VGGNNPHVEE AA-GLLSRRI IFWWWRRIQT LQ--DDDDGP --LLLEEEIF EWAPPN---V VGGNNPHVEE AA-GLLSHHI IHWWWRRIQT LQ--DDDDGP --LLLEEEIF EWAPPN---V VGGNNPDVEE AA-GLLSHHL LHWWWRRIQT LT--DDDDGP --LLLEEEIF EWAPPN---V VGGNNPDVKK AA-GLLSHHL LYWWWRRIQT LP--DDDDGP --LLLEEEIF EWAPPN---V VGGNNPDVEE AA-GLLSHHL LYWWWHHIQT LS--DDDDGP --LLLEEEIF EWAPPN---V VGGNNPDVEE AA-GLLSHHL LYWWWRRIQT LS--DDDDGP --LLLEEEIF EWAPPN---V VGGNNPDVEE AA-GLLSHHL LYWWWRRIQT LS--DDDDGP --LLLEEEIF EWAPPN---V VGGNNPDVEE AA-GLLSHHL LYWWWRRIQT LS--DDDDGP --LLLEEEIF EWAPPN---V VGGNNPDVEE AA-GLLKHHL LHWWWRRIQT LL--DDDDGP --LLLEEEIF ---------- ---------- ---------- ---------- ---------- ---------- ISHSSN---L LGGRRDPASS AA-SRRGIIT T--------- ---------- ---------- IQCSSL---F FGGEELCLTT AA-SGGVIIS SCDYYMMIES LP--DDDDQA NPLLLCCCLS EWAPPK---A AGGKKMEVQQ AA-GMMHSSL LNWWWEERQT IDEEDDDDGP --LLLEEEIF EWAPPK---A AGGKKMDVQQ AA-GHHHSSL LNWWWEELQT IDKKDDDDGP --LLLEEEIF SWAPPT---A AGGDDLHVAA DD-GLLRHHL LTILLRRLQT LDNNTTTTGP --LLLEEEIF SWAPPK---A AGGNNLHVAA DD-GLLRHHL LHYWWGGIQT LDDDKKKKGP --LLLEEEIF SWAPPK---A AGGDDLHVAA DD-GLLSHHL LHYWWGGMQL IDEETTTTGP --LLLEEEIF SWAPPK---A AGGNNLHVAA DD-GLLSHHL LHYWWGGIQL IDPPTTTTGP --LLLEEEIF SWAPPA---A AGGDDLHVQQ DD-GLLRHHL LHYWWGGLQT LDSSTTTTGP --LLLEEEVF EWSPPN---H HGGNNPHVGG EE-GLLNSSV VHFWWSSYQT IDQQLLLLGP --LLLEEEVF EWSPPN---H HGGNNPHVPP EE-GLLNSSV VHFWWTTHQT IDMMRRRRGP --LLLEEEVF LRGPPV---T TDDEELCQPP EE-PLLKCCK KRY------- ---------- ---------- EWAPPK---L LGGHHPDCDD DDRTQQCRRL LNYWWEELQT IDDDDDDDGP --LLLEEEIF EWAPPN---K KGGKKNDLEE DDMSQQCRRL LNYWWTTLQT IDSSDDDDGP --LLLEEEIF RPEPPI---M MSSEESLKKK TTGPLLQHHV VAV------- ---------- ---------- SFGWWSNYYM MGGMMLDAEE AAMKRRNTTI IVWLLTTPKV FNGGPPPP-- --LLLEEEIF SFGWWNNYYM MGGMMLDPEE AAMKHHNTTV VVWLLTTPKV FDGGPPPP-- --LLLEEEIC PPLLHPTTKL MMMGNMMVLL LKKDLSSSSW WWFYY-EDGK KWKVIIIEEI IPAEEEEGII PPLLHPTTKL MMMGNVVVTT TKKDLSSSSW WWFYY-EDGK KWRVIIIDDI IEAQQQEGVV PPAAHPVVRE YYYGGVVVTT TTTNLEEEGW WWWRR-EGGK KFKTAAATTI IPAEEETALL PPAAHPVVRE YYYGGVVVTT TTTNLEEEAW WWWRR-EGGK KFKTAAATTI IPPEEEPKLL PPAAHPSSKD YYYGGVVVTT TTTNLQQQGF FWWQQKDDGT TFKTIIITTI IDPVVVDALL PPAAHPTTKA YYYGNCCVLL LKKDLSSSSW WWYRR-DKDK KWKVIIIEEI IPAEEEDPVV PPAAHPTTKA YYYGNCCVLL LKKDLSSSAW WWYRR-DNGS SWKVIIIDDI IPAEEESEII PPAAHPAART YYYGGVVVLL LEEDLSSSAW WWHRR-QNGS SWKVIIIEEI IPAEEEEPLL FFLLHPSSAT QQQGGCCASS SNNIQRRRFN NEG------- ----TTTWWS SVEKKKQVKK FFLLHPDDAT QQQGGCCASS SNNIQRRRFN NGG------- ----TTTWWS SVEKKKQVKK FFLLHPDDAA QQQGGCCASS STTIQRRRFN NGG------- ----TTTWWS SVEKKKQVKK FFLLHPDDAA QQQGGCCASS STTIQRRRFN NDG------- ----TTTWWS SAQKKKQVKK FFLLHPDDAA QQQGGCCASS STTIQRRRFN NGG------- ----TTTWWS SVEKKKQVKK FFLLHPDDAA QQQGGCCASS STTIQRRRFN NGG------- ----TTTWWS SVEKKKQVKK FFLLHPDDAA QQQGGCCASS STTIQRRRFN NGG------- ----TTTWWS SVEKKKQVKK FFLLHPDDAA QQQGGCCASS STTIQRRRFN NGG------- ----TTTWWS SVEKKKQVKK FFLLHPAAAS QQQGGCCASS STTIQRRRFN NGG------- ----TTTWWS SVEKKKEVKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSIIHKNNIN QQQDVVVEFF FSSGRGGGGP PAY------- ----AAAVVV VLKRRRDLAA FFLLHPDDAA QQQGGCCASS STTVFRRRFE EDG------- ----KKKWWA AAEKKKKVEE FFLLHPDDAD QQQGGCCASS SSSIFRRRFE EDG------- ----KKKWWA AAEKKKQVEE FFLLHPAAKD TTTGGSSASS SNNMIRRRFT TDG------- ----SSSWWS SHELLLPVQQ FFLLHPAAKD TTTGGSSASS SNNMIRRRFT TDG------- ----SSSWWN NHEIIISVQQ FFLLHPSSKD TTTGGSSASS SNNMIRRRFN NDD------- ----TTTWWS SYEIIISVEE FFLLHPSSKD TTTGGSSASS SNNMIRRRFN NDE------- ----TTTWWS SHEVVVSVEE FFLLHPSSKD TTTGGCCASS SNNMVRRRFT TDG------- ----SSSWWS SHEVVVSIRR FFLLHPTTSE HHHAGCCASS SGGIFRRRIV VENSS----- --T-TTTHHA AATLLLFISS FFLLHPTTSE HHHAGCCASS SAAIFRRRID DKNPP----- --K-VVVQQT TASLLLTIEE ---------- ---------- ---------- ---------- ---------- ---------- FFLLHPRREN QQQGGCCAXX XXXXXXXXX- ---------- ---------- --------EE FFLLHPKKKA EEEGGCCAAA AKKVFHHHFK KDSDD----- --EFEEEAAK KKVIIIPGGG ---------- ---------- ---------- ---------- ---------- ---------- FFPPWSNNAN YYYATTTASS SQQLWLLLID DAG------- ---------- ------EWAA CCAAWEAAHN YYYCSTTASS SQQLWLLLID DEG------- ---------- ------EWAA LFFFFAVPLV TTTDDDIDDD DKFLLYYLGE EVVRQYYDFV TKVGGGGGGF RDDHH----- LFFFFMVPLV TTTDDDIDDD DRFLLYYLGE ELLRQYYDHR ARVGGGGGGY RPPHH----- LFFFFAVPLV TTTDDDIDDD DRFLLYYCGE EMMRQYYDHV ASVGGGGGGA RPPHH----- LFFFFAVPLV TTTDDDIDDD DRFLLYYCGE EMMRQYYDRK ASVGGGGGGA RPPHH----- LFFFFACPLV TTTDDDIDDD DKYLLYYCGE EMMHQYYDMV TKVGGGGGGV KPPHH----- LFFFFAVPLV TTTDDDIDDD DRFLLYYCGD DLLLQYYDFK TKVGGGGGGV RTTHHG---- LFFFFAVPLV TTTDDDINDD DRFLLYYCGE ELLHQYYDFR TKVGGGGGGV RGGHH----- LFFFFAVPLV TTTDDDINDD DRFLLYYCGE ELLRQYYDFR TSVGGGGGGV KAAHH----- GLLLLEMPLI TTTDDDILDD DRFLLYYNLD DIIRQYYDQR TQIGGGGGGI RGGSSQLLEE GLLLLEMPLI TTTDDDILDD DRFLLYYNLD DIIRQYYDKR TQIGGGGGGI KGGSSQLLEE GLLLLEMPLI TTTDDDILDD DRFLLYYNLD DLLRQYYDQR TQLGGGGGGI KGGPPQLLEE GLLLLEMPLI TTTDDDILDD DHFLLYYNLD DIIRQYYDQR TQLGGGGGGI KGGPPQLLDD GLLLLEMPLI TTTDDDILDD DRFLLYYNLD DLLRQYYDQR TQLGGGGGGI KGGPPQLLEE GLLLLEMPLI TTTDDDILDD DRFLLYYNLD DLLRQYYDQR ---------- ---------- GLLLLEMPLI TTT------- ---------- ---------- ---------- ---------- GLLLLEMPLI TTTDDDILDD DRFLLYYNLD DLLRQYYDQR TQLGGGGGGI KGGPPQLLEE GLLLLEMPLI TTTDDDILDD DRFLLYYNLD DMMRQYYDKR VQIGGGGGGI KGGPPQLLEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KVVVVSLSEF PPPPPPAWSS DLLIIIIS-- ---------- ---------- ---------- GLLLLEMPLI TTTDDDILDD DRFLLYYNLD DIIRQYYDRK VQIGGGGGGI RGGPPTLLEE GMMMMEMPLI TTTDDDILDD DRFLLYYNLD DIIRQYYDRK VQIGGGGGGI RGGPPTLLEE NLLLLEMPLI TTTDDDFLDD DRFLLYYNLD DIIRQYYNKV TQLGGGGGGI KSSPPAIIGG NLLLLEMPLI TTTDDDFLDD DRFLLYYNLD DIIRQYYNKK TQVGGGGGGI KSSPPVVVKK NLLLLEMPLI TTTDDDFLDD DRFLLYYNLD DIIRQYYNKV TQIGGGGGGL KSSPPKVVGG NLLLLEMPLI TTTDDDFLDD DRFIIYYNLD DIIRQYYNKV TQIGGGGGGL KSSPPKVVGG NLLLLEMPLI TTTDDDFVDD DRYLLYYNLD DIIRQYYNAV AQVGGGGGGL KSSEEVVVTT GLLLLEMPLI TTTDDDILDD DRFLLYYCLD DIIRQYYDLK NQVGGGGGGV TSSNNKLLEE NLLLLDMPLI TTTDDDILDD DRFLLYYCLD DIIRQYYDKK NQVGGGGGGI STTTTKLLEE ---------- ---------- ---------- ---------- ---------- ---------- NIIIIMMGMM TTTDDDILDD DRYLLYYNRD DVVRQYYDAR TQVGGGGGGI RAAPPRLLNN SAAAADMGMI SSSDDDIIDD DRFLLYYCRD DVVRQYYDEK TQLGGGGGGI SLLPPVVVKK ---------- ---------- ---------- ---------- ---------- ---------- DNNNNADILP VVVDDDISDD DQTLLWWSMK KTTRLFFDHF IEKDDDDRRV ---------- DEEEEAKVLP VVVDDDISDD DSRLLWWTMK KTTRLFFDHR VEKGGGGAAV ---------- ---------- -------AAG HHLLLGGGAP LLLEERRRRV VVVTNSSTFF PEEGGKWMMV ---------- -------SSG AAAAAGGGAP IIISSRRRRV VVITNSSSFF P--GGRWMMA ---------- -------NNG RRFFFGGGGP VVVEERRRRV VVWTNSSTFF PDDGGPAQQV ---------- -------NNG KKFFFAAAGP VVVEERRRRV VVWTNSSTFF PDDGGPVEEV ---------- -------NNG KKFFFYYYGP VVVEEKKKKV VVWTNSSTFF PGGDDGAMMV ---------- ------AKKN GGLLLGGGGP VVVEERRRRV VVFTNSSAFF PEEGGDWMMV ---------- ------ATTS AALLLGGGGP VVVEERRRRV VVFTNSSAFF PDDGGKWMMV ---------- -------AAS GGLLLGGGGP VVVEERRRRV VVFSNSSSFF PVVGGRWIIA E-DDQEELLT QPPPLVVKKG KKIIIGGGGP IIIQQKKKKL LLATTSSDFF -PPDDIEGGS E-DDQEELLT QPPPLVVKKG KKVVVGGGGP IIIQQKKKKL LLVTTSSAFF -PPNNIEGGS E-DDQEELLK QPPPLVVKKG KKVVVGGGGP IIIQQKKKKL LLVTTSSAFF -PPDDIEGGS D-DDQEELLD QPPPLVVKKG KKVVVGGGGP IIIQQKKKKL LLVTTSSAFF -PPDDIEGGS E-DDQEELLK QPPPLVVKKG KKVVVGGGGP IIIQQKKKKL LLITTSSAFF -PPDDIEGGS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- E-DDEEELLK QPPPLVVKKG KKVVVGGGGP IIIQQKKKKL LLITTSSAFF -PPDDIEGGS E-DDQEELLK QPPPLVVKKG KKVVVGGGGP IIIQQKKKKI IIVTTSSDFF -PPDDIEGGS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- E-DDKDDLLE QPPPVIVKKG KKVVVGGGGP IIIQQKKKKL LLVTNSSKFF -PPDDIEGGS E-DDKEELLE QPPPVTVKKG KKIIIGGGGP IIIQQKKKKI IIVTSSSIFF -PPDDLEGGA G-EEDGGKKT QSSVPEIQQG QQLLLGGGGP IIIQQKKKKL LLVTNSSAFF -PPGGVKGGS K-DDDGGEET QSSVPEIQQG KKLLLGGGGP IIIQQKKKKL LLVTNSSAFF -PPKKVQGGS G-EEDGGNNS QFFVPQIKKG KKLLLGGGGP IIIQQKKKKL LLATNSSAFF -PPEEMKGGS G-EEDGGNNT QFFVPQIKKG KKLLLGGGGP IIIQQKKKKL LLATNSSAFF -PPEEMKGGS T-EEDDDKKE QYYVPQVKKG HHLLLGGGGP IIIQQKKKKI IIVTNSSRFF GQQDDVKGGS E-GGEKK--- PIIALYVKKG RRIIIGGGGP LLLQQKKKKL LLVTTSSKFF -PPEEVSGGA E-EEDHHDD- EIIALYVKKG RRIIIGGGGP LLLQQKKKKL LLVSTSSKFF -PPEEVSGGA ---------- ---------- -----GGGGP IIIQQKKKKL LLVTNSSTFF -PPNNVEGGS N-DDPEELLK APPPVFLKKG RRLLLGGGGP LLLQQRRRRL LLVSSSSPFF -PPEEVAGGG KEDDKEELLK RPPARYVKKG RRLLLGGGGP LLLQQKKKKL LLVSSSSPFF -PPKKVQGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVSSKKKKV VVFSSSSN-- ------KGGK ---------- ---------- ---------- VVVSSQQQQL LLYTSSSN-- ------KGGK KLAANNN--- -------PPP GGIIDDKKEE FFFFE----- RHQQQGGDAA ASSSSSSCCP KVVVNNN--- -------PPP GGLLEEKKEE FFFFR----- RHQQQGGDAA ASSSSSSCCP LAAAGGG--- -------PPP GGLLAADDDD YYYFD----- RHQQQGGDCC CSSSSSSCCP MAVVGGG--- -------GGG GGLLDDKKDD YYYFD----- RHQQQGGDCC CSSSSSSCCP MAVVGGG--- -------EEE GGLLDDKKDD FFFFA----- RHQQQGGDCC CSSSSSSCCP KLAAGGG--- -------PPP GGFFDDPPKK FFFWK----- RHQQQGGDCC CSSSSSSCCP KVVVNNN--- -------PPP GGFFDDPPNN FFFFE----- RHQQQGGDAA ASSSSSSCCP KAAADDD--- -------PPP GGLLDDPPGG FFFVD----- RHQQQGGDSS SSSSSSSCCP VMQQVVVDDD DDDDDTTVVV GGLLNNPPNN FFFFKPPGGG LHEEEGGDCC CSSSIIIII- VMQQIIIDDD DDDDDTTAAA GGLLNNPPNN FFFFKPPGGG LHEEEGGDCC CSSSIIIII- VMQQIIIDDD DDDDDTTVVV GGLLNNPPNN FFFFKPPGGG LHEEEGGDCC CSSSIIILL- VMQQIIIDDD DDDDDTTVVV GGLLNNPPNN FFFFKPPGGG LHEEEGGDCC CSSSIIILL- VMQQVVVDDD DDDDDTTVVV GGLLNNPPNN FFFFKPPGGG LHEEEGGDCC CSSSIIIII- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VMQQVVVDDD DDDDDTTVVV GGLLNNPPNN FFFFKPPGGG LHEEEGGDCC CSSSIIIII- VMQQIIIDDD DDDDDTTVVV GGLLNNPPNN FFFFKPPGGG LHEEEGGDCC CTTTIIILL- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VMQQIIIDDD DDDDDTTEEE GGLLNNPPNN FFFFKPPGGG LHEEEGGDCC CSSSIIIVV- VMQQIIIDDD DDDDDTTKKK GGLLNNPPNN FFFFKPPGGG LHEEEGGDCC CTTTIIIII- HIQQIIIDDD DDDDDTTEEE GGIINNPPNN FFFFAPPGGG LHEEEGGDCC CTTTIIIII- HIQQIIIDDD DDDDDTTEEE GGIINNPPNN FFFFAPPGGG LHEEEGGDCC CTTTIIIII- HIQQIIIDDD DDDDDTTEEE GGIINNPPNN FFFFDPPGGG LHEEEGGDCC CTTTIIIII- HIQQIIIDDD DDDDDTTEEE GGIINNPPDD FFFFDPPGGG LHEEEGGDCC CTTTIIIII- HMQQIIIDDD DDDDDTTEEE GGIINNPPNN FFFFAPPGGG LHEEEGGDCC CTTTIIIII- TMQQVVVNNN NNDDDPPEEE GKIINNRRDD FFFFKEEGGG LHEEEGGDCC CTTTIIIII- TMQQIIIDDD DDDDDPPIII GHIINNKKNN FFFFKPPGGG LHEEEGGDCC CTTTIIIII- VMQQIIIDDD DDDDDTTEEE GGVVNNKKNN FFFFKPPGGG LHDDDCCDSS STTTIIIAA- TIQQLLLDDD DDDDDVVEEE GGLLNNEENN FFFFGPPGGG LHEEE----- ---------- HILLIIIDDD DDDDDTTVVV GGLLNNEEDD FFFFNPPGGG LHEEEGGDCC CTTTIIILLN ---------- ---------- ---------- ---------- ---------- ---------- DDQQYYYLLL LLAAAYYNNN DGLLVVEEDD FFFFEGGGGG RHIIISSALL LYYY------ DDQQFFFLLL LLLLLYYYYY DGLLKKEEQQ FFFFAKKGGG RHQQQAAALL LYYYPPPGGG ------- ------- VVRR--- VV----- VV----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AA----- ------- ------- RRVVQQE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSSSKKAKKK PPPSSEATTP CRRRTAAPPP PTGAAARDDG MQQQLLPPRT TTAQLSLLLG gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSSVVVVRKA YQQEEAAAAF QVVPPREEES KKKTRSVPGL VESSVAAAVV VVSSSAAVWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------LL ---------- ---------- ---------- ---------- ---------- ---------- ---------- MAAGGRRSST NNNPPHNNNP LAASPPHPRV PLRLRPPPTT TIVVVPRLCC ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----AIVPFR RRDDDTTFYY PSKMAMKEYA ---------- ---------- ---------- -----MAKLP PPDDDTTFYY PTRDAMREYA ---------- ---------- ---------- ------MSMP PPDDDTTFHH ASELAMQEYL ---------- ---------- ---------- ------MTMP PPDDDTTFHH ASKLAMEEYL ---------- ---------- ---------- ------MTLP PPDDDTTFYY PSKLAMEEFL ---------- ---------- ---------- -----MATWP PPDDDSSFYY PSRLAAKEYA ---------- ---------- ---------- -----MVTWP PPDDDTTFYY PSRMAVKEYV ---------- ---------- ---------- -----MASWP PPDDDTTFYY PSKMAMQEYA ---------- ---------- ---------- --MAKCTK-C CCGGGGGYPP TPEAMK-EYP ---------- ---------- ---------- ---------- ---------- -----M-EYP WHWLPGHGGG GGAAVVLAPA RRGGPPPP-A AAHSQCGK-C CCGGGGGYPP SPEAMK-EYP ---------- ---------- ---------- ---------- ---------- ----MK-EYP ---------- ---------- ---------- --MAKCGN-C CCGGGGGYSS TPEAMK-EYP ----AREGGG GGAATTLSVA QQPPPPPPAS SSTAKCGN-C CCGGGGGYSS TPEAMK-EYP ---------- ---------- ---------- --MAKCGN-C CCGGGGGYSS TPEAMK---- ---------- ---------- ---------- --MAKCGN-C CCGGGGGYSS TPEAMK-EYP -MGLGEPGGG GGHHAAQWFL SSGGWWWWED DDTAKCGD-C CCGGGGGYPP TPEAMK-EYP LKNSQCGFFF FFDDTTNELH TTYYLLLLFT TTSPKCGN-C CCGGGGGYSS TPEAMK-EYP ---------- ---------- ---------- --MAKCGN-C CCGGGGGYSS TPEAMK-EYP CPHARSVLLL LLQQIIMGAA AAVVAAAAAA AANGTCCHTK KKGGGGGYAA TPEAMEKEYT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MKCGS-C CCGGGGGYKK SPDAMK-EYP ---------- ------MTVL DDHHVVVVEK KKKSVNGCCS SSGGGGGYAA SPESMS-EYT ---------- ------MTVL QQHHVVVVEK KKVNQQGCCS SSGGGGGYAA SPEAMS-EYT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----RMLQG GGGGGGGYAA TPAAMS-EYT ---------- ---------- ----AAAAAA AANGACCGGT TTGGGGGYAA TPEAMEKEYT ---------- ---------- ----MMMMPN NNCGKCHG-- --GGGGGYAA SPDAIK-EFT ---------- ---------- ----MMMM-- --CPKCHG-- --GGGGGYAA SPDAIK-EFT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----SESKCC CCGGGGGYAA TPDAVRNEYV ---------- ---------- ---------- ---------- ---------- ----MRSEYV ---------- ---------- ---------- ---------- --MMMGGLII T-DILISRFN ---MKRFGGG GG-------- --AAAAAA-A AALAGLPFRF FFAAAEETCC QSYMPKIEYW ---MKFVSSS SSGGSSMFAL RRAASSSSLA AALAAAPAGR RRAAAEETCC ASYMKKIEYW LLTTTGGNNR RAAAAFIVDV VPPPKTKIVH KLLPPDLLHH HFGWNCSLLC ---N--PNNN LLTTTGGNNA APPPPFLVDV VPPPKTKVIY KLLPPDLLHH HFGWNCSYYC ---N--PFFF LLFFFSS--R RPPPPALVDV VPPPGTKIVH TMMPPDFFHH HFGWNCSLLS ---LGGAFFF LLFFFSS--K KPPPPALVDV VPPPGTQIVH TMMPPDFFHH HFGWNCSLLS ---LGGAFFF LLAAASS--K KPPPPGLVDV VPPPTKQIVH QMMPPDFFHH HFGWNCSLLS ---LGGAFFF FFRRRKK--Q QPPPPAIVDV VPPPARSIVG QMMPPDLLHH HFGWNCSLLC ---NPPPHHH LLAAANN--K KPPPPAMVDV VSSSQTQVVG VMMPPGLLHH HFGWNCSLLC ---NPPPHHH LLRRREE--R RPPPPALVDL LPPPDTQIVG RMMPPDLLHH HFGWNCALLC ---YPPPHHH IITTTGGEEA APPPPYLTDV VPPPKQQVIH RMMPPDLLHH HSGWNCS--- ----GGSTTT IITTTGGEEA APPPPYLTDV VPPPKHQVIH RMMPPDLLHH HSGWNCS--- ----GGSTTT IITTTGGEEA APPPPYLTDI IPPPKQQVIH RMMPPDLLHH HSGWNCS--- ----GGSTTT IITTTGGEEA APPPPYLTDV VPPPKQQVIH RMMPPDLLHH HSGWNCS--- ----GGITTT IITTTGGEEA APPPPYLTDV VPPPKQQVIH RMMPPDLLHH HSGWNCS--- ----GGSTTT IITTTGGEEA APPPPYLTDV VPPPKQQVIE ---------- ---------- ---------- -------EEA APPPPYLTDV VPPPKQQVIH RMMPPDLLHH HSGWNCS--- ----GGSTTT IITTTGGEEA APPPPYLTDV VPPPKQQVIH RMMPPDLLHH HSGWNCS--- ----GGSTTT IITTTGGEEA APPPPYLTDV VPPPKQQVIH RMMPPDLLHH HSGWNCS--- ----GGSTTT IITTTGGEEA APPPPYLTDV VPPPKQQVIH RMMPPDLLHH HSGWNCS--- ----GGSTTT IITTTGGEEA APPPPYLTDV VPPPKQQVIH RMMPPDLLHH HSGWNCS--- ----GGSTTT VVTTTGGNNK KLLLLYLTDL LPPPSTQVIH RVVIIDLLHH HSGWNCS--- ----GGPSSS ---------- ---------- ---------- -MMPPDLLHH HSGWNCS--- ----GGASSS IITTTGGNNK KPPPPYLTDV VPPPKSQVIH RMMPPDLLHH HSGWNCS--- ----GGSSSS VVTTTGGEEK KPPPPYLTDV VPPPSTKVIH RVVPPDLLHH HTGWNCS--- ----GGPSSS VVTTTGGEEK KPPPPYLTDL LPPPNTKVIH RVVPPDLLHH HTGWNCS--- ----GGPSSS ---------- ---------- ---------- -MMPPDLLHH HSGWNCS--- ----GGASSS VVTTTGGDDK KPPPPYLTDV VPPPSSSVIH RMMPPDLLHH HSGWNCS--- ----GGASSS VVTTTGGNNK KPPPPYLTDV VPPPNTQVIH RVVTTDLLHH HSGWNCS--- ----GGPSSS PPNNNAADDG GPPPPAITDV VPPPETQVIS RVVPPDVVHH HTGWNCS--- ----DDPTTT PPHHHAADDG GPPPPAITNV VPPPETQIIS RVVPPDVVHH HTGWNCS--- ----DDPTTT ---------- ---------- ---------- ---------- ---------- ---------- VVLLLDDEEH HGGGGYLTDV VPPPATQVIH RTTNNNLLHH HSGWNCSHHF VVV-GGEVVV VVLLLDDPPH HGGGGYLTDV VPPPETQIVH RTTNNDLLHH HSGWNCSYYY VVVESSTVVV LLIIIRRYYD DIIIIDRNRM MGGGQLSVLK DVVKKDEELD DSQPTRL--- ----GGRVVV LLGGGMMDDE EQQQQKLTDL LPPPGTQVIN SVVGGNAAHH HGGFS----- ---------- LLGGGVVDDE EQQQQKLTDA APPPKQKVVN TVVGGNAAHH HSDFT----- ---------- IERRFLLSSS SSSRRRYYYI IITKNNRREP KKVEEKVSSS SLHHTTTHCP PIIAALGNE- LERRYLLSSS SSSRRRYYYI VVTKDDRRRP AKIEVGRTTT TYHHTTTHCP PIIAALGGP- LERRFLLSSS SSSRRRYYYV IITKHHTTQA RKIEEAKTTT SPHHTTTHCP PIVTTLGGAG IERRYLLSSS SSSRRRYYYI IITKDDTTKA KKIEEKKTTT SPHHTTTHCP PIVTTLGGGG LERRYLISSS SSSRRRYYYI VVVKEELLKA KKIEEAKTTT SPHHTTTHCP PIVTTLGGGG MERRYLLSSS SSSRRRYYYI LLTKDDLLKP FKVETERTTT SPHHTTTHCP PIVAALGNA- VERRYLISSS SSSHHHTTTI LLTKDDTTQP KKVDEERTTT APHHTTTHCP PIIAALGSP- VERRYLISSS SSSRRRHHHI VVTKDDRREP RKVEERRTTT SPHHTTTHCP PVVAALGSP- KSRNKLLSSS SSSRRRYYYV VVVGEERRAP KKVEEAKCCC STHHTTTHCA AEMNNTLGD- KSRDKLISSS SSSRRRYYYV VVVGEERRAP KKVEEAKCCC GLHHTTTHCA AEMSSSLGD- KSRTKLLSSS SSSRRRYYYV VVVGDDRRAP KKVEDAKCCC GVHHTTTHCA AEMSSTLGD- KARTKLLSSS SSSRRRYYYV VVVGEERRAP KKVEDTKCCC GFHHTTTHCP PEMSSTLGD- KSRTKLLSSS SSSRRRYYYV VVVGEERRAP KKVEDAKCCC ALHHTTTHCA AEMSSSLGD- ---------- ---------- ---------- ----DAKCCC ALHHTTTHCA AEMSSSLGD- KSRTKLLSSS SSSRRRYYYV VVVGEERRAP KKVEDAKCCC ALHHTTTHCA AEMSSSLGD- KSRTKLLSSS SSSRRRYYYV VVVGEERRAP KKVEDAKCCC ALHHTTTHCA AEMSSSLGD- KSRNKLFSSS SSSRRRYYYV VVVGEERRAP KKVEDEKCCC GPHHTTTHCP PEMSSTLGD- KSRTKLL--- ---------- ---------- ---------- ---------- ---------- KSRTKLLSSS SSSRRRYYYV VVVGEERRAP KKVEDAKCCC ALHHTTTHCA AEMSSSLGD- AKRRFLLSSS GGGRRRYYYV VVTADDRRTP SKVEDENIII GPHHTTTHCA ADMSSCLGD- KVRNKLLSSS SSSRRRYYYV VVVGDDRRAP RKTEEWKCCC ALHHTTTHCG GEMSSSIGD- KVRNKLLSSS SSSRRRYYYV VVVGDDRRAP RKTEEWKCCC APHHTTTHCG GEMSSSLGD- AERRFLLSSS GGGRRRYYYV IITKNNRRSP SKVDDQKTTT APHHTTTHCA AEMSSCLGD- AQRRFLISSS GGGRRRYYYV IITKNNRRAP SKVEDTKTTT APHHTTTHCA AEMSSCIGD- ADRRYLLSSS GGGRRRYYYA IITKNNRRAP SKYDEEKTTT APHHTTTHCA AELSSCLGD- VDRRYLLSSS GGGRRRYYYA IITKNNRRAP SKYDEDKTTT APHHTTTHCT TELSSCLGD- ASRRFLLSSS GGGRRRYYYV VVTLDDRRAP AKVEDEKTTT GPHHTTTHCA AEMSSCLGD- EKRSHLLSSS DDDRRRYYYI IIVEEERRKI YHTEKSLNNN SPHHTTTHCA ANMSSTLGE- EKRSHLLSSS DDDRRRYYYV IIVEEERREI YHTEKALNNN SPHHTTTHCA ANMSSTLGE- -----MLSSS GGGVVVGGGK VVVG------ ---------- ---------- ---------- PTRDRLLSSS DDDRRRFFFV IITGDDRRAP KKVEDKGAAA TPHHTTTHCP PNMSSIMGD- PKRDRLLSSS DDDFFFYYYI LLVVDDRRKP EKTDDKSHHH TPHHTTTHCA ANMSSVMGD- QGGPQMLGGG KKKRRRYYYV TTSLSSWWDK QP--DKFLLL ASHHTTTDYP PAKDDGVNE- -DRRFFLTTT NNNRRRFFFI FFVHDDSSNP KKTDFDSGGG VPHHTTTFAP PMIGGLSND- -DRRYLLTTT SSSKKKFFFV FFVHDDAARP VKTTFKSGGG VPHHTTTYAP PMIGGLSNN- --EG-GPGML LDHHSEEELG GWEIIGDQYY ---------- ------LLAW LL----NNEV --DGRGPGLL LDHHTEEEIG GWEVVGPQYY ---------- ------FFAW LL----SSGV GKDGTGAGIM MDCCTDDDLG GWEIIGPQDD ---------- ------KKHW LL----RRDY GKDGTGPGIM MDCCTEEELG GWEIIGPQTT ---------- ------LLHW LL----RRDY GEDGTGPGIL LDCCTEEELG GYEMMGEQTT ---------- ------KKHW LL----RRDY --EG-GPGML LDAASEEELG GWEVVGPQYY ---------- ------FFAW LL----YYDT --EG-GPGIL LDHHNEEELG GWEIIGDQYY ---------- ------LLHW LL----YYDT --EG-GPGVM MDHHSDDDLG GWEVVGPQQQ ---------- ------LLAW LL----YYDT --LQGGKSLL LDGGTEEEKG GWEKKGASPP ---------- ------MMGY PP----HHNV --PQGGKGLL LDGGTEEEKG GWEKKGEAPP ---------- ------MMGY PP----HHNI --SKGGKGLL LDGGTEEEKG GWEQQGAAPP ---------- ------MMGY PP----HHNV --PEGGKGLL LDGGTEEEKG GWEQQGAAPP ---------- ------LLGY PP----HHNV --VKGGKGLL LDGGTEEEKG GWERRGAAPP ---------- ------SSGY PP----HHNV --VKGGKGLL LDGGTEEEKG GWERRGAAPP ---------- ------LLGY PP----HHNV --VKGGKGLL LDGGTEEEKG GWERRGAAPP ---------- ------LLGY PP----HHNV --VKGGKGLL LDGGTEEEKG GWERRGAAPP ---------- ------LLGY PP----HHNV --PKGGKGLL LDGGTEEEKG GWERRGSAPP ---------- ------MMGY PP----HHNV ---------- ---------- ---------- ---------- ---------- ---------- --VKGGKGVL LLPPREEESG G--------- ---------- ---------- ---------- --KEGAANLL LLDDENNNKG GGSNNFPISS ---------- ------KKEY NNYYYYWWGL --PYGGKGLL LDGGTEEEKG GWEAAEAAPP ---------- ------FFGY PP----HHNV --PCGGKGLL LDGGTEEEKG GWEVVESAQQ ---------- ------FFGY PP----HHNV --KDGAENLL LLDDDNNNKG GWEKKHSPLL ---------- ------FFGY PP----HHNT --KDGAENLL LLDDENNNKG GWEKKHSPLL ---------- ------FFGY PP----HHNT --EEGAKNLL LLDDDNNNKN NWEKKHSPLL ---------- ------FFGY PP----HHKT --EEGAKNLL LLDDDNNNKN NWEKKISPLL ---------- ------YYGY PP----HHKT --KEGAANLL LLDDENNNKG GWEKKHSPLL ---------- ------FFGY PP----HHKT --ANGPSNLL LDGGTEEEKG GWPAAKTVPP ---------- ------FFNY PP----RRNV --ADGPSNLL LDGGTEEEKG GWPAAKVVPP ---------- ------FFNY PP----RRNI ---------- ---------- ---------- ---------- ---------- ---------- --AEGAK-VE EFDDNEEEVG GWSRRRKALL ---------- ------CCGY PP----FFNV --AEGAK-IL LFDDDNNNIG GWTKKKKALL ---------- ------CCGY PP----FFDV --SLSPVNQT TSKKEGGGSA AGEAAFEEII ---------- ------LLQN GG----RREK --DDHGRAEY YNDDGYYYAT TWMPPDDMQQ GAAAAVVAVD AAAVVDYYGA II----KKNV --KDHGRAEY YTNNGYYYAT TWIPPGDLRR GAAAAIIKT- KKKYYDYYDA PP----KKNL LEVPNNN--- ---IIED--- LLLKDDGGNN NNRHHHWDLL LRRKKKHHLE EENMAL---- MEVPRRR--- ---FFEE--- FFFSEEGGNN NNKHHHWDLL LRRRRRYYLQ EEHMVL---- MELPPPP--- ---FFEN--- IIIVAAGGHH HHRHHHWDLL LRRRRRQQLA QQHMAL---- MELPPPP--- ---FFEN--- IIIVSSGGHH HHRHHHWDLL LRRRRRQQLA NNHMAL---- MELPPPP--- ---FFEN--- IIIVSSGGHH HHKHHHWKLL LRRKKKQQLA NNHMAL---- LETPDDD--- ---VVED--- LLLVGGGGRR RRRHHHWDLL LRRRRRQQFD EEHLVF---- LETPRRR--- ---VVES--- VVVLAAGGHH HHRHHHWDLL LRRRRRQQLA EEYMAL---- METPNNN--- ---IIEG--- LLLDNNGGRR RRRHHHWDLL LRRRRRQQVE EEHMVL---- MEAPNNN--- ---FFKDFFF NNNP--GGSS SSRFFFWDWW WHHEEEQQM- --DLIP---- MEAPNNN--- ---FFKDFFF NNNP--GGSS SSHHHHWDWW WHHEEEQQM- --DLIP---- MEAPNNN--- ---FFRDFFF NNNP--GGSS SSHHHHWDWW WHHEEEQQL- --DLIP---- MEAPNNN--- ---LLRDFFF NNNP--GGSS SSHYYYWDWW WRREEEQQL- --DLIP---- MEAPNNN--- ---LLRDFFF NNNP--GGSS SSHYYYWDWW WHHEEEQQL- --DLIP---- MEAPNNN--- ---LLRDFFF NNNP--GGSS SSHYYYWDWW WHHEEEQQL- --DLIP---- MEAPNNN--- ---LLRDFFF NNNP--GGSS SSHYYYWDWW WHHEEEQQL- --DLIP---- MEAPNNN--- ---LLRDFFF NNNP--GGSS SSHYYYWDWW WHHEEEQQL- --DLIP---- MEAPNNN--- ---VVQNFFF NNNP--GGKK KKHHHHWDWW WHHEEEQQM- --DHIP---- ---------- ---------- ---------- ---------- ---------- ---------- -IHSNNN--- ---RRLTSSS RRRD--AAGG GGI------- ---------- ---------- FICSLLL--- ---YYTTAAA EEEL--HHVV VVICCCDNYY YRRVVVEEL- --DAGANNNI MEAPKKK--- ---FFALFFF KKKM--GGHH HHSNNNWDWW WHHRRRQQLE --DLIP---- MEAPKKK--- ---FFALFFF KKKM--GGHH HHSNNNWDWW WHHRRRQQLK --DLIP---- MSAPTTT--- ---FFTKFFF DDDL--GGRR RRHTTTIQLL LGGEEEQQLN --TLLP---- MSAPKKK--- ---FFLQFFF NNNL--GGRR RRHHHHYSWW WGGEEEQQLD --KLLP---- MSAPKKK--- ---FFSKFFF DDDL--GGSS SSHHHHYSWW WGGEEEQQLE --TLLP---- MSAPKKK--- ---FFSKFFF NNNL--GGSS SSHHHHYSWW WGGEEEQQLP --TLLP---- MSAPAAA--- ---FFRTFFF DDDL--GGRR RRHHHHYDWW WGGEEEQQLS --TLLP---- MESPNNN--- ---IIKKFFF NNNP--GGNN NNSHHHFEWW WKKKKKQQLQ PPLALP---- MESPNNN--- ---IIKKFFF NNNP--GGNN NNSHHHFEWW WKKKKKQQLM PPRALP---- -LGPVVV--- ---VVCREEE EEEL--IIKK KKCRRRY--- ---------- ---------- MEAPKKK--- ---FFRRYYY HHHPRRGGCC CCRNNNYRWW WRREEEQQLD --DLTP---- MEAPNNN--- ---WWRRWWW KKKNMMGGCC CCRNNNYKWW WQQTTTQQLS --DITP---- SREPIII--- ---AAFESSS EEESGGPPQQ QQHAAAVL-- ---------- ---------- MSGWSSSNNN YYYMMDFQQQ MMMLMMGGNN NNTVVVWDLL LRRQQQKKVG AAP------- LSGWNNNNNN YYYMMDFKKK MMMLMMGGNN NNTVVVWDLL LKKQQQKKVG AAP------- ----EEELLR RPPPPLLDKK FFFIIIMVVL DDSLLLWWWF YEDGWWNNNE KIIIAPLE-N ----EEEVVR RPPPPLLDKK FFFVVVVVLT DDSLLLWWWF YEDGWWQQQE RIIIAPFE-P ----EEEVVR RPPPPAADRR FFFVVVVVVT NNGTTTWWWW REGGFFHHHK KAAIAPATDE ----EEEVVR RPPPPAADRR FFFVVVVVVT NNATTTWWWW REGGFFHHHE KAAIPPAPEK ----EEEIIR RPPPPAADKK FFFCCCVVVT NNGTTTWWWW QDDGFFEEEK KIIIPPADDD ----EEELLR RPPPPAADKK FFFVVVCVIL DDSTTTWWWY RDKDWWAAAR KIIIAAADDQ ----EEELLR RPPPPAADKK FFFMMMCVVL DDALLLWWWY RDNGWWHHHK KIIIAPASDQ ----EEELLR RPPPPAADRR FFFVVVVVVL DDALLLWWWH RQNGWWGGGR KIIIAPAEDQ -LLLEEEIIR RFFFFLLDAA FFFVVVCALS IIFEEEEEEG ---------- -TTSEVIQPS -LLLEEEIIR RFFFFLLDAA FFFVVVCALS IIFEEEGGGG ---------- -TTSEVIQPS -LLLEEEIIR RFFFFLLNAA FFFVVVCALS IIFQQQGGGG ---------- -TTSEVIQPP -LLLEEEIIR RFFFFLLNAA FFFVVVCALS IIFEEEDDDG ---------- -TTSQVIQPP -LLLEEEIIR RFFFFLLNAA FFFVVVCALS IIFEEEGGGG ---------- -TTSEVIQPP -LLLEEEIIR RFFFFLLNAA FFFVVVCALS IIFEEEGGGG ---------- -TTSEVIQPP -LLLEEEIIR RFFFFLLNAA FFFVVVCALS IIFEEEGGGG ---------- -TTSEVIQPP -LLLEEEIIR RFFFFLLNAA FFFVVVCALS IIFEEEGGGG ---------- -TTSEVIQPP -LLLEEEIIR RFFFFLLDAA FFFVVVCALS IIFEEEGGGG ---------- -TTSEVIEPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ILLLCCCLLR RSSSSIIWII YYYDDDVEVF GGGDDDAAAY ---------- -AAVKKLDYY -LLLEEEIIR RFFFFLLDAA LLLVVVCALS VVFKKKDDDG ---------- -KKAEVIKPS -LLLEEEIIR RFFFFLLNAA LLLVVVCALS IIFKKKDDDG ---------- -KKAEVIQPS -LLLEEEIIR RFFFFLLDKK FFFVVVSALS MMFQQQDDDG ---------- -SSSEAIPKP -LLLEEEIIR RFFFFLLDKK FFFVVVSALS MMFQQQDDDG ---------- -SSNEVISEP -LLLEEEIIR RFFFFLLDKK YYYVVVSALS MMFSSSDDDD ---------- -TTSEVISKP -LLLEEEIIR RFFFFLLDKK FFFVVVSALS MMFSSSDDDE ---------- -TTSEVISKP -LLLEEEVVR RFFFFLLDKK YYYVVVCALS MMFAAADDDG ---------- -SSSEAISKP -LLLEEEVVR RFFFFLLESS FFFVVVCALS IIIEEEEEEN S--------- TTTATVAFPS -LLLEEEVVR RFFFFLLESS FFFVVVCALS IIIEEEKKKN P--------- KVVTSVATPS ---------- ---------- ---------- ---------- ---------- ---------- -LLLEEEIIR RFFFFLLNEE YYYVVVCAFX XXX------- ---------- ---------- -LLLEEEIIR RFFFFLLNKK FFFVVVCALA VVFSSSDDDS D--------- EEEKVDIPKL ---------- ---------- ---------- ---------- ---------- ---------- -LLLEEEIIR RFFFFPPGAA FFFSSSTALS LLIDDDAAAG ---------- -------EQA -LLLEEEIIR RCCCCAAGHH FFFTTTTALS LLIGGGEEEG ---------- -------EQA LPPPEIILLK KKAVPPPDDD IIDISSFLLL LLWIGRYSNN NVVVVLLTTG KKVGIFFHRR LPPPPVVLLK KKMVPPPDDD IIDISSFLVV VLWLGRYTNN NRRRRLLAAG RRVGLYYHRR LPPPPLLLLQ QGAVPPPDDD IIDLSSFLVV VCWTGRYSDD DVVVVLLAAG SSVGIAARRR LPPPPLLLLQ QGAVPPPDDD IIDLSSFLVV VCWTGRYSDD DKKKKLLAAG SSVGIAARRR LPPPDLLLLK KGACPPPDDD IIDLSSYLVV VCWLGHYSDD DVVVVLLTTG KKVGIVVKKK LPPPPVVLLK KKAVPPPDDD IIDLSSFLVV VCWTGLYSDD DKKKKLLTTG KKVGIVVSRR LPPPPIILLK KKAVPPPDDD IINLSSFLVV VCWTGHYSDD DRRRRLLTTG KKVGIVVRRR LPPPPLLLLK KGAVPPPDDD IINLSSFLVV VCWTGRYSDD DRRRRHHTTG SSVGIVVRKK KKKKVKKGGW WPEMPGGDDD IILLSSFLFF FNWHGRYSNN NRRRRLLTTG QQIGSIIVRR KKKKVKKGGW WPEMPGGDDD IILLSSFLFF FNWHGRYSNN NRRRRLLTTG QQIGSIIVKK KKKKVKKGGW WPEMPGGDDD IILLSSFLFF FNWHGRYSDD DRRRRLLTTG QQLGSIIVKK KKKKVKKGGW WPEMPGGDDD IILLSSFLFF FNWHGRYSDD DRRRRLLTTG QQLGSIIVKK KKKKVKKGGW WPEMPGGDDD IILLSSFLFF FNWHGRYSDD DRRRRLLTTG QQLGSIIVKK KKKKVKKGGW WPEMPGGDDD IILLSSFLFF FNWHGRYSDD DRRRRLL--- ---------- KKKKVKKGGW WPEMPGG--- ---------- ---------- ---------- ---------- KKKKVKKGGW WPEMPGGDDD IILLSSFLFF FNWHGRYSDD DRRRRLLTTG QQLGSIIVKK KKKKVKKGGW WPEMPGGDDD IILLSSFLFF FNWHGRYSDD DRRRRLLVVG QQIGSIIVKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AVVVVAAKKF FVSLSNNPPP AAWIFFLIFF FS-------- ---------- ---------- KKKKVEEGGW WPEMPGGDDD IILISSFLFF FNWHGRYTDD DKKKKLLVVG QQIGSIILRR KKKKVEEGGW WPEMPGGDDD IILISSFLFF FNWHGRYTDD DKKKKLLVVG QQIGSIIQRR LKKKVQQNNW WPEMPGGDDD FFLISSFLFF FNWHGRYEDD DVVVVLLTTG QQLGLIIQKK LKKKVQQNNW WPEMPGGDDD FFLISSFLFF FNWHGRYEDD DKKKKLLTTG QQVGLIIQKK LKKKVEENNW WPEMPGGDDD FFLISSFLFF FNWHGRYEDD DVVVVLLTTG QQIGLLLQKK LKKKVEENNW WPEMPGGDDD FFLISSFIFF FNWHGRYEDD DVVVVLLTTG QQIGLLLQKK LKKKVRRNNW WPEMPGGDDD FFVISSYLLL LNWHGRYEDD DVVVVLLAAG QQVGLLLQKK KKKKVSSGGW WPEMPAADDD IILISSFLVV VCWHGRYSDD DKKKKLLNNS QQVGSVVHTT KKKKVEENNW WPDMPAADDD IILISSFLVV VCWHGRYSDD DKKKKLLNNS QQVGSIIHSS ---------- ---------- ---------- ---------- ---------- ---------- -QQQGEENNG GEMMGGGDDD IILISSYLFF FNWHGRYSDD DRRRRLLTTG QQVGAIIQRR VDDDTGGSSG GEDMGGGDDD IIIISSFLVV VCWHGRYTDD DKKKKLLTTG QQLGAIICSS ---------- ---------- ---------- ---------- ---------- ---------- KAAAVAADDI IPADIPPDDD IISIAATLII ISFDGRFSDD DFFFFQQIIY EEKDQVVN-- KAAAVAADDI IPAKVPPDDD IISISSRLVV VTFDGRFSDD DRRRRQQVVY EEKGQVVN-- RAAD------ ---------- -GGKTGGAAP PMLLEISGRY YYTSLYSTTW DDDNQFPPPE REEP------ ---------- -GGETGGAAP PMIISVSGRY YYTSLYSSSW NNNNQFPPP- RAAP------ ---------- -GGTAGGGGP PMVVEISGRY YYTSLYSTTW DDDDQFPPPD RTTP------ ---------- -GGAAAAGGP PMVVEISGRY YYTSLYSTTW DDDDQFPPPD KTTP------ ---------- -GGTGYYGGP PMVVEISGRY YYTSLYSTTW DDDEQFPPPG RAATGG---- ---------- ANNANGGGGP PMVVEISGRY YYTSLYGAAV DDDPQFPPPE RAAG------ ---------- ASSENGGGGP PMVVEISGRY YYTSLYRAAW DDDEQFPPPD KAAA------ ---------- -SSPNGGGGP PMVVEVSGRY YYSSLYASSW DDDEQFPPPV RGGGQQVE-D DQQLTTPELL VGGRPGGGGP PMIIQLSGRY YYTSLYSDDW DDDKQF---P KGGGQQVE-D DQQLTTPELL VGGRPGGGGP PMIIQLSGRY YYTSLYSAAW DDDKQF---P KGGGQQVE-D DQQLKKPELL VGGKPGGGGP PMIIQLSGRY YYTSLYSAAW DDDKQF---P KDDGQQVD-D DQQLDDPELL VGGQAGGGGP PMIIQLSGRY YYTSLYSAAW DDDKQF---P KGGGQQVE-D DQQLKKPELL VGGRAGGGGP PMIIQLSGRY YYTSLYSAAW DDDKQF---P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KGGGQQVE-D DEELKKPELL VGGRAGGGGP PMIIQLSGRY YYTSLYSAAW DDDKQF---P KGGGQQVE-D DQQLKKPELL VGGRPGGGGP PMIIQLSGRY YYTSLYSDDW DDDKQF---P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RGGGTTVE-D DKKLEEPDVV VGGKPGGGGP PMIIQLSGRY YYTSLYSKKW DDDKQF---P RGGGTTVE-D DKKLEEPDVV VGGIPGGGGP PMIIQLSGRY YYTSLYSIIW DDDKQF---P KGGSAAAG-E EDDKTTSDPP IGGKRGGGGP PMIIQLTGRY YYTSLFSAAW DDDKQF---P KGGSVVAK-D DDDETTSDPP IGGKRGGGGP PMIIQLSGRY YYTSLFSAAW DDDKQF---P KGGSKKAG-E EDDNSSFDPP IGGSRGGGGP PMIIQLSGRY YYTSLFSAAW DDDRQF---P KGGSKKAG-E EDDNTTFEPP IGGSRGGGGP PMIIQLSGRY YYTSLFSAAW VVVVSF---P KGGSVVYT-E EDDKEEYSPP VGGRRGGGGP PMIIQLSGRY YYTSLFSRRW DDDEQFGGGQ TEESKKVE-G GEE---IELL VGGKEGGGGP PMLLQLSGRY YYTSLYKKKW DDDDQF---P SEETKKVE-E EDDD--IPLL VGGQEGGGGP PMLLQLSGRY YYSSLYKKKW DDDDQF---P ---------- ---------- -----GGGGP PKIIQLSGRY YYTSFYSTTW DDDKQF---P RDDARRVN-D DPPLKKPEVV LGGRLGGGGP PMLLQLSGRY YYSSLFSPPW DDDKQF---P SDDLVVIKED DKKLKKPPRR VGGREGGGGP PMLLQLSGRY YYSSLYSPPW DDDKQF---P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MVVSQSGRY YYSSLLANNW DDD------- ---------- ---------- ---------- -MVVSSSGRY YYTSLLANNW DDD------- EELKGVLNN- ---PSSGGLL LLEIDFFFVF GEEE------ --ASSSQVGD SSDSSCCYYP --LRGAVNN- ---PEEGGLL LLELEFFFVF GRRR------ --AAAAQVGD TTDSSCCYYP DDVPAVAHG- ---PDDGGLL LLTLAYYYVF PDDDGG---- --YAAAQIGD TTDSSCCYYP DDVPGVANG- ---GNNGGLL LLELDYYYVF PDDDGG---- --YAAAQIGD TTDSSCCYYP GGRGAVANG- ---ENNGGLL LLTLDFFFVF PAAAGG---- --YSSSQIGD TTDSSCCYYP EEIDGVLDG- ---PNNGGII IIEFDFFFLW PKKKGG---- --HPPPQVGD SSDSSCCYYP DDIKGVVDN- ---PDDGGMM MMQFDFFFVF GEEE------ --QVVVQIGD SSDSSCCFFP VVIRGAAED- ---PGGGGLL LLSLDFFFTV GDDDGG---- --LPPPQIGD SSDSSCCYYP PPLIRSMLVD DTTVNNGGLL LLKLNFFFVF GKKKEELGPP PPAAAAELGD SSDIIII--- PPLIRSMLID DTTANNGGLL LLKLNFFFVF GKKKEELGPP PPAAAAELGD SSDIIII--- PPLIRSMLID DTTVKKGGLL LLKLNFFFVF GKKKEELGPP PPAAAAELGD SSDIILL--- PPLIRSMLID DTTVKKGGLL LLTLNFFFVF GKKKEELGPP PPAAAAELGD SSDIILL--- PPLIRSMLVD DTTVKKGGLL LLKLNFFFVF GKKKEELGPP PPAAAAELGD SSDIIII--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPLIRSMLVD DTTVKKGGLL LLKLNFFFVF GKKKEELGPP PPAAAAELGD SSDIIII--- PPLIRSMLID DTTVKKGGLL LLKLNFFFVF GKKKEELGPP PPAAAAEIGD SSDIILL--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPMIKSMLID DTTEKKGGLL LLKLNFFFVF GKKKEEGGPP PPVAAAELGD SSDIIVV--- PPLLKAMLID DTTKKKGGLL LLKLNFFFVF GKKKEEDGPP PPVAAAEIGD SSDIIII--- PPLVESILID DTTEKKGGLL LLKINFFFVF GAAAEEDGPP PPAAAAEMGD SSDIIII--- PPLVESILID DTTENNGGLL LLKINFFFVF GAAAEEDGPP PPSAAAEMGD SSDIIII--- PPLMDSIIID DTTEKKGGLL LLSINFFFVF GDDDEEEGPP PPAAAAEMGD SSDIIII--- PPIMESIIID DTTEKKGGLL LLTINFFFVF GDDDEEDGPP PPSAAAEMGD SSDIIII--- QQLVKSMLID DTTEKKGGLL LLSINFFFVF GAAAEEEGPP PPSAAAEMGD SSDIIII--- PPHVKAMVVD DPPESSKKMM MMEINFFFIF GKKKIIGGPP PPYAAAEMGD SSDIIII--- PPNVRAMLID DPPITTHHMM MMVINFFFIF GKKKVVGGPP PPYAAAEMGD SSDIIII--- PPVVKSMLID DTTEKKGGLL LLTVNFFFVF GKKKEENGPP PPCAAADICD SSDIIAA--- PPMVAGIVLD DVVENNGGMM MMKLNFFFVF GGGGEEYGPP PPGPPPEM-- ---------- PPMVSGIVID DTTVNNGGII IISLNFFFVF ANNNEEYGPP PPSPPPEMGD SSDIILLAAN ---------- ---------- ---------- ---------- ---------- ---------- ----KKDAYA AYYNWWGGKK KKELVFFFVF YEEELLLG-- ---AAAIMSA SSS------- ----KKDEFL LYYYWWGGKK KKELKFFFIF YAAAEELG-- ---PPPQMAA AAGPPGGDDG ------- ------- SSSR--- SSS---- SSS---- ------- ------- SSS---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- DDD---- ------- ------- NNNVQQA 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSAKKAKKQP STPCRTAAAP PPTGGGTTAR LDDMQQSSLP PPRLLLSLTT GGGSSIIIKQ gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------A gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EAAAWFAAAV VVLLLAASSS SSSTTRRRSG GLESSAVVVV VAAKQVVVPP PPPSSSQAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------L ---------- ---------- ---------- ---------- ---------- ---------- GRSSATPPPN NNRRRTTPTP PPPSSPPPPR RVLRLVRRRR RPPYRTIINN NNNVVVPPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A VPDDPPTTYY YPSPPMMKPP PDDAYAAACC ---------- ---------- ---------- AKDDPPTTYY YPTPPDMRPP PDDAYAAAAA ---------- ---------- ---------- MSDDPPTTHH HASPPLMQPP AEEAYLLLLL ---------- ---------- ---------- MTDDPPTTHH HASPPLMEPP ANNAYLLLLL ---------- ---------- ---------- MTDDPPTTYY YPSAALMEPP VKKAFLLLMM ---------- ---------- ---------- ATDDPPSSYY YPSPPLAKPP PTTAYAAAMM ---------- ---------- ---------- VTDDPPTTYY YPSPPMVKPP AKKAYVVVRR ---------- ---------- ---------- ASDDPPTTYY YPSPPMMQPP RRRGYAAALL ---------- ---------- -------MAK TKGGPPGGPP PTPLLAK-PP REEVYPPPCC ---------- ---------- ---------- ---------- ------M-PP REEVYPPPCC WWLLPGKKKG VIIPPAAAAR GLLPP--HSQ GKGGPPGGPP PSPLLAK-PP REEVYPPPCC ---------- ---------- ---------- ---------- ------K-PP REEIYPPPCC ---------- ---------- -------MAK GNGGPPGGSS STPLLAK-PP REEVYPPPCC ----ARAAAG TQQVVAAAAQ PMMPPAATAK GNGGPPGGSS STPLLAK-PP REEVYPPPCC ---------- ---------- -------MAK GNGGPPGGSS STPLLAK--- ---------- ---------- ---------- -------MAK GNGGPPGGSS STPLLAK-PP REEVYPPPCC GGLLGEEEEG APPFFLLLLS GQQWWEETAK GDGGPPGGPP PTPQQAK-PP REEVYPPPCC NNSSQCLLLF TTTLLHHHHT YCCLLFFSPK GNGGPPGGSS STPLLAK-PP REEVYPPPCC ---------- ---------- -------MAK GNGGPPGGSS STPLLAK-PP REEVYPPPCC HHAARSLLLL IEEAAAAAAA VEEAAAANGT CHGGPPGGAA ATPLLAEKPP RKKVYTTTCC ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MK GSGGPPGGKK KSPLLAK-PP REEVYPPPCC ---------- -AAVVLLLLD HGGVVEEKSV GCGGPPGGAA ASPIISS-PP RSSIYTTTAA ---------- -GGVVLLLLQ HAAVVEEVNQ GCGGPPGGAA ASPLLAS-PP RTTIYTTTAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MLGGPPGGAA ATPLLAS-PP SKKIYTTTAA ---------- ---------- ---AAAANGA CGGGPPGGAA ATPLLAEKPP RKKLYTTTCC ---------- ---------- ---MMPPCGK HGGGPPGGAA ASPAAAK-PP REELFTTTAA ---------- ---------- ---MM--CPK HGGGPPGGAA ASPAAAK-PP REELFTTTAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------S SKGGPPGGAA ATPLLARNPP VKKLYVVVCC ---------- ---------- ---------- ---------- ------RSPP RKKLYVVVTT ---------- ---------- ---------- --MMPPGGII IT---IISDD DFFYFNNNWW --MMKREEEG ---------- ALLAA--LAG PFAADDEECC CQSPPMKIGG QEEVYWWWTT --MMKFIIIS SHHAALLLLR ALLSSLLLAA PAAADDEECC CASPPMKIGG QDDVYWWWTT LLYTGGGTTT NRRAFIIIAV VVVVDDDVVP PPKETYSVKV EEYIINELLH HFGGGWACCC LLYVGGGTTT NAAPFLLLAV VVVVDDDVVP PPKPTYGIKL DDYIIGELLH HFGGGWACCC LLSPDDDFFF -RRPALLLAV VIIIDDDVVP PPGSTYGVTV TTNTTGEFFH HFGGGWACCC LLSPDDDFFF -KKPALLLAV VIIIDDDVVP PPGPTYGVTV TTNKKGEFFH HFGGGWACCC LLSPDDDAAA -KKPGLLLAV VVVVDDDVVP PPTEKFGVQL IINKKGEFFH HFGGGWACCC FFDPEEERRR -QQPAIIIAV VVVVDDDVVP PPAPRYAVQV AAHAAGELLH HFGGGWACCC LLNPMMMAAA -KKPAMMMCV VVVVDDDVVS SSQSTFGVVT DDYTTGELLH HFGGGWACCC LLDPGGGRRR -RRPALLLGV VLLLDDDLLP PPDGTYAVRV EENAAAELLH HFGGGWACCC IIYRNNNTTT EAAPYLLLAT TVVVDDDVVP PPKPQYSIRL PPYLLKELLH HSGGGWTCCC IIYRNNNTTT EAAPYLLLAT TVVVDDDVVP PPKPHYSIRL PPHLLKELLH HSGGGWTCCC IIYGNNNTTT EAAPYLLLAT TVVVDDDIIP PPKPQYCIRL PPNLLRELLH HSGGGWACCC IIYRNNNTTT EAAPYLLLAT TVVVDDDVVP PPKPQYCIRL PPHLLKELLH HSGGGWTCCC IIYRNNNTTT EAAPYLLLAT TVVVDDDVVP PPKPQYCIRL PPNLLKELLH HSGGGWTCCC IIYRNNNTTT EAAPYLLLAT TVVVDDDVVP PPKPQYCI-- ---------- ---------- ---------- EAAPYLLLAT TVVVDDDVVP PPKPQYCIRL PPNLLKELLH HSGGGWTCCC IIYRNNNTTT EAAPYLLLAT TVVVDDDVVP PPKPQYCIRL PPNLLKELLH HSGGGWTCCC IIYRNNNTTT EAAPYLLLAT TVVVDDDVVP PPKPQYSIRL PPYLLKELLH HSGGGWTCCC IIYRNNNTTT EAAPYLLLAT TVVVDDDVVP PPKPQYCIRL PPNLLKELLH HSGGGWTCCC IIYRNNNTTT EAAPYLLLAT TVVVDDDVVP PPKPQYCIRL PPNLLKELLH HSGGGWTCCC VVYNGGGTTT NKKLYLLLAT TVVVDDDLLP PPSPTYSIRL PPHIIGKLLH HSGGGWSCCC ---------- ---------- ---------- ---------- --NTTNELLH HSGGGWTCCC IIYRSSSTTT NKKPYLLLAT TVVVDDDVVP PPKPSYSIRL PPNVVNELLH HSGGGWTCCC VVYAGGGTTT EKKPYLLLAT TVVVDDDVVP PPSPTYSIRL PPYVVGELLH HTGGGWSCCC VVYAGGGTTT EKKPYLLLAT TVVVDDDLLP PPNPTYSIRL PPYVVGELLH HTGGGWSCCC ---------- ---------- ---------- ---------- --FVVGELLH HSGGGWSCCC VVYTGGGTTT DKKPYLLLAT TVVVDDDVVP PPSPSYSIRL PPFVVGELLH HSGGGWSCCC VVYNGGGTTT NKKPYLLLGT TVVVDDDVVP PPNPTYSIRL PPHVVGELLH HSGGGWACCC PP-----NNN DGGPAIIIFT TVVVDDDVVP PPEDTFCIRV DDHIIGEVVH HTGGGWACCC PP-----HHH DGGPAIIIFT TVVVNNNVVP PPEETFCIRV DDNIIGEVVH HTGGGWACCC ---------- ---------- ---------- ---------- ---------- ---------- VVQPNNNLLL EHHGYLLLAT TVVVDDDVVP PPAPTYCIRT YYSKKHELLH HSGGGWTCCC VVQPNNNLLL PHHGYLLLST TVVVDDDVVP PPEPTYCVRT FFRKKGELLH HSGGGWACCC LLHGDDDIII YDDIDRRRKN NPPPRRRMMG GGQFLGGLDG PPVLLEKEEL DSQQQPPRRR LLGVEEEGGG DEEQKLLLVT TIIIDDDLLP PPGATRGISV SSG--REAAH HGGGGFA--- LLGAEEEGGG DEEQKLLLVT TVVVDDDAAP PPKPQYGVTL SSG--REAAH HSDDDFD--- SSS-PPNNG- --PIFLGRRI IYIITKPNNE IIVEEPEEEK KVVSSGYHTT TVVHHHCCAY SSS-PPNNA- --PLYLARRI IYIITKPDDR AAIEEPEEVV GRRTTGYHTT TVVHHHCCAY SSS-PPLLTG GGALFLGRRI IYVVTKPHHQ HHIEEPDDEL AKKTTGYHTT TVVHHHCCGY SSS-PPLLAG GGAIYLGRRI IYIITKPDDK HHIEEPEEEF KKKTTGYHTT TIIHHHCCGY SSS-PPLLTG GGALYLGRRI IYIIVK-EEK HHIEEPEEEF AKKTTGYHTT TIIHHHCCGY SSS-PPNNAP PPPMYLGRRI IYIITKPDDK AAVEEPEETA ERRTTGYHTT TVVHHHCCGY SSS-PPNNAP PPPVYLDHHI ITIITKPDDQ VVVDDPNNEA ERRTTGYHTT TVVHHHCCGY SSA-PPYYAP PPPVYLGRRI IHIITKPDDE VVVEEPEEEH RRRTTGYHTT TIIHHHCCGY SSS-----FG GGSKKLGRRI IYVVVGSEEA HHVEEASSEQ AKKCCNVHTT TSSHHHCCGV SSS-----FG GGSKKLSRRI IYVVVGSEEA HHVEEPNNEH AKKCCNLHTT TSSHHHCCGV SSS-----FG GGSKKLCRRI IYVVVGSDDA HHVEEAEEDH AKKCCGLHTT TSSHHHCCGV SSS-----YG GGIKKLARRI IYVVVGTEEA HHVEEPKKDH TKKCCNLHTT TSSHHHCCGV SSS-----FG GGSKKLSRRI IYVVVGSEEA HHVEEPEEDH AKKCCELHTT TSSHHHCCGV ---------- ---------- ---------- -----PKKDH AKKCCELHTT TSSHHHCCGV SSS-----FG GGSKKLSRRI IYVVVGSEEA HHVEEPKKDH AKKCCELHTT TSSHHHCCGV SSS-----FG GGSKKLSRRI IYVVVGSEEA HHVEEPKKDH AKKCCELHTT TSSHHHCCGV SSS-----FG GGSKKLSRRI IYVVVGTEEA HHVEEAKKDH EKKCCGLHTT TSSHHHCCGV SSS-----FG GGSKKLS--- ---------- ---------- ---------- ---------- SSS-----FG GGSKKLSRRI IYVVVGSEEA HHVEEPKKDH AKKCCELHTT TSSHHHCCGV SSS-----HG GGPAFLSRRV VYVVTATDDT HHVEESEEDA ENNIIGLHTT TSSHHHCCGI SSS-----YG GGAKKLCRRI IYVVVGTDDA HHTEEPYYEF WKKCCGLHTT TSSHHHCCGI SSS-----YG GGSKKLCRRI IYVVVGSDDA HHTEEPYYEF WKKCCGLHTT TSSHHHCCGI SSS-----HG GGPAFLSRRI IYVVTKTNNS HHVDDPAADI QKKTTGLHTT TSSHHHCCGL SSS-----HG GGPAFLGRRV VYVVTKTNNA HHVEEPEEDS TKKTTGLHTT TSSHHHCCGI SSS-----HG GGAAYLSRRI IYAATKENNA YYYDDPKKEA EKKTTGLHTT TAAHHHCCGI SSS-----HG GGAVYLSRRI IYAATKENNA YYYDDPKKEA DKKTTGLHTT TAAHHHCCGI SSS-----HG GGPAFLSRRV VYVVTLKDDA HHVEEAEEDA EKKTTGLHTT TSSHHHCCGI SSS-----HD DDPEHLCRRI IYIIVENEEK EETEEPSSKH SLLNN-LHTT TSSHHHCCGI SSS-----HD DDPEHLCRRI IYVVVENEEE QQTEEPSSKH ALLNN-LHTT TSSHHHCCGI ---------- -----MKVVE EGKKVGG--- ---------- ---------- ---------- SSSVPP--GG GGEPRLCRRI IFVVTGTDDA AAVEEG--DL KGGAADCHTT TTTHHHCCGI SSSVDDEESS SSTPRLSFFI IYIIVVTDDK VVTDDG--DL KSSHHNVHTT TTTHHHCCGI IIL------G GGRQQMSRRL LYVVSLYSSD YY------DI KFFLLVLHTT TAADDDYYTL ---------- ----FFGRRI IFIIVHSDDN HHTDDT--FK DSSGGGVHTT TFFFFFAASM ---------- ----YLGKKI IFVVVHSDDR SSTTTD--FE KSSGGGVHTT TLLYYYAARL ISAAAGNE-- EG-EGGGGIL MLLYSSFEPP PPLLDRQY-- ---------L AWL-EEEVVV ISAAAGGP-- DGREGGGGIF LLLDTTFEPP PPIIYRQY-- ---------F AWL-GGGVVI VSTTTGGAGK DGTDGPPGIF IMMETTFDVV VVLLDRQD-- ---------K HWL-DDDYYV VSTTTGGGGK DGTNGPPGVF IMMETTFEVV VVLLDRQT-- ---------L HWL-DDDYYV VSTTTGGGGE DGTDGPPGIF ILLETTFEII IILLDRQT-- ---------K HWL-DDDYYV VTAAAGNA-- EG-KGGGGIA MLLQSSFEPP PPLLERQY-- ---------F AWL-DDDTTV ISAAAGSP-- EG-EGGGGIF ILLDNNLEVV VVLLDRQY-- ---------L HWL-DDDTTL VSAAAGSP-- EG-DGGGGVF VMMESSFDPP PPLLERQQ-- ---------L AWL-DDDTTV MVNNNLGD-- LQGNGGGSFV LLLETTFEVV VVKKPGSP-- ---------M GYP-NNNVVV MISSSLGD-- PQGNGGGGFV LLLETTFEVV VVKKPGAP-- ---------M GYP-NNNIIV MISSSLGD-- SKGNGGGGFV LLLETTFEVV VVKKPGAP-- ---------M GYP-NNNVVI MVSSSLGD-- PEGNGGGGFV LLLKTTFEVV VVKKPGAP-- ---------L GYP-NNNVVI MISSSLGD-- VKGNGGGGFV LLLETTFEVV VVKKPGAP-- ---------S GYP-NNNVVI MISSSLGD-- VKGNGGGGFV LLLETTFEVV VVKKPGAP-- ---------L GYP-NNNVVI MISSSLGD-- VKGNGGGGFV LLLETTFEVV VVKKPGAP-- ---------L GYP-NNNVVI MISSSLGD-- VKGNGGGGFV LLLETTFEVV VVKKPGAP-- ---------L GYP-NNNVVI MISSSLGD-- PKGNGGGGFV LLLETTFEVV VVKKPGAP-- ---------M GYP-NNNVVI ---------- ---------- ---------- ---------- ---------- ---------- MISSSLGD-- VKGNGDDGSL VLL-RRLECC CCSS------ ---------- ---------- MISSSLGD-- KEGNAGGNGF LLLSEEFNVV VVKKRLIS-- ---------K EYNYGGGLLW MISSSIGD-- PYGNGGGGFV LLLETTFEVV VVKKEGAP-- ---------F GYP-NNNVVI MISSSLGD-- PCGNGGGGFV LLLETTFEVV VVKKEGAQ-- ---------F GYP-NNNVVI MISSSLGD-- KDGNAGGNGF LLLSDDFNVV VVKKPGPL-- ---------F GYP-NNNTTI MISSSIGD-- KDGNAGGNGF LLLSEEFNVV VVKKPGPL-- ---------F GYP-NNNTTI LVSSSLGD-- EEGNAGGNGF LLLSDDFNII IIKKPGPL-- ---------F GYP-KKKTTI LVSSSLGD-- EEGNAGGNGL LLLSDDFNII IIKKPDPL-- ---------Y GYP-KKKTTI MISSSLGD-- KEGNAGGNGF LLLSEEFNVV VVKKPGPL-- ---------F GYP-KKKTTI MISSSLGE-- ANGTPGGNFL LLLKTTFEPP PPKKDEVP-- ---------F NYP-NNNVVI MISSSLGE-- ADGSPGGNFL LLLKTTFEPP PPKKDGVP-- ---------F NYP-NNNIII ---------- ---------- ---------- ---------- ---------- ---------- MISSSMGD-- AEGNAGG-DF VEEKNNFELL LLVVGDAL-- ---------C GYP-NNNVVV MISSSMGD-- AEGYAGG-DF ILLSDDFNCC CCIIGDAL-- ---------C GYP-DDDVVV KQDDDVNE-- SLSVPLLNGI QTTHEENGLL LLSSSQEI-- ---------L QNG-EEEKKE ITGGGSND-- DDHGGTTALV EYYDGGEYVV VVAATAMQAV VVAVGVVAGY GAI-NNNVVL ITGGGSNN-- KDHGGTTALV EYYAGGEYVV VVAATDLRAI IIKTGYYAGY DAP-NNNLLV VSSEWAPPPN ---TEDDG-L KEEHHLLKD- YNFWWDDDLR RKKIHLTLLG EERRAAAL-- ISSEWTPPPR ---CEEEG-F SEECCLLKEG YNVWWDDDLA RRRLYIDLLG EERRVVVL-- VSSEWAPPPP ---QENNG-I VEEDDLLLAN YHFWWDDDLR RRRVQIDLLG QQQQAAAL-- VSSEWAPPPP ---QENNG-I VEEDDLLLSN YHFWWDDDLR RRRVQIDLLG NNQQAAAL-- VSSEWGPPPP ---QENNG-I VEEDDLLLSN YHFWWKKKLR RKKVQIDLLG NNQQAAAL-- VSSEWGPPPD ---MEDDG-L VDDIILLLGA YRFWWDDDLT RRRLQIDFFG EEQQVVVF-- LSSEWGPPPR ---MESSG-V LDDEELLLAG YHVWWDDDLY RRRLQLDLLG EEQQAAAL-- VSSEWGPPPN ---MEGGG-L DQQIILLLNK YRIWWDDDLR RRRLQLDVVG EEQQVVVL-- VTTEWAPPPN ---VKDDGFN PHHVVEEA-G YSVWWDDDWQ HEEIQLQMMT --GGIIIP-- VTTEWAPPPN ---VKDDGFN PHHVVEEA-G YSVWWDDDWQ HEEIQLQMMK --GGIIIP-- ITTEWAPPPN ---VRDDGFN PDDVVEEA-G YSVWWDDDWQ HEEIQLTLLQ --GGIIIP-- ITTEWAPPPN ---VRDDGFN PDDVVKKA-G YSVWWDDDWQ REEVQLPLLQ --GGIIIP-- ITTEWAPPPN ---VRDDGFN PDDVVEEA-G YSVWWDDDWQ HEEVQLSLLK --GGIIIP-- ITTEWAPPPN ---VRDDGFN PDDVVEEA-G YSVWWDDDWQ HEEVQLSLLK --GGIIIP-- ITTEWAPPPN ---VRDDGFN PDDVVEEA-G YSVWWDDDWQ HEEVQLSLLK --GGIIIP-- ITTEWAPPPN ---VRDDGFN PDDVVEEA-G YSVWWDDDWQ HEEVQLSLLK --GGIIIP-- ITTEWAPPPN ---VQNNGFN PDDVVEEA-G YKVWWDDDWQ HEEVQLLMMP --GGIIIP-- ---------- ---------- ---------- ---------- ---------- ---------- -AAISASSSN ---LLTTGSR DPPAASSA-S VG-------- ---------- ---------- WWWIQCSSSL ---FTTTGAE LCCLLTTA-S VVLDDNNNYI RVVDELPLLQ --QQGGGANN ITTEWGPPPK ---AALLGFK MEEVVQQA-G YHVWWDDDWT HRRIQIDLLG --GGIIIP-- ITTEWGPPPK ---AALLGFK MDDVVQQA-G YHVWWDDDWT HRRVQIDLLG --GGIIIP-- ITTSWGPPPT ---ATKKGFD LHHVVAAD-G YRCIIQQQLA GEERQLDLLG --GGLLLP-- ITTSWGPPPK ---ALQQGFN LHHVVAAD-G YRVYYSSSWP GEEKQLDLLG --GGLLLP-- ITTSWGPPPK ---ASKKGFD LHHVVAAD-G YSVYYSSSWP GEEKQIDLLG --GGLLLP-- ITTSWGPPPK ---ASKKGFN LHHVVAAD-G YSVYYSSSWP GEEKQIDLLG --GGLLLP-- ISSSWGPPPA ---ARTTGFD LHHVVQQD-G YRVYYDDDWP GEEKQLDLLG --GGLLLP-- ITTEWGPPPN ---HKKKGFN PHHVVGGE-G YNIFFEEEWD KKKLQIDLLP PPGGLLLP-- ITTEWGPPPN ---HKKKGFN PHHVVPPE-G YNIFFEEEWD KKKLQIDLLP PPGGLLLP-- -IILRGPPPV ---TCRRDEE LCCQQPPE-P VKVYY----- ---------- ---------- VSSEWGPPPK ---LRRRGYH PDDCCDDDRT YCFYYRRRWQ REEFQIDLLG --GGTTTP-- VSSEWGPPPN ---KRRRGWK NDDLLEEDMS YCFYYKKKWS QTTYQIDLLG --GGTTTP-- EDDRPDPPPI ---MFEESSE SLLKKKKTGP KQEVVLLL-- ---------- ---------- LSSSFTWWWS NYYMDFFGQM LDDAAEEAMK FNQWWDDDLH RQQKKFNVVP AA-------- VSSSFTWWWN NYYMDFFGKM LDDPPEEAMK FNTWWDDDLH KQQKKFDVVP AA-------- -----RRPLP TMMFINNMMV VVSSLLSSSW FY---GGKKK KKWNAEKEPP APPEEEG--N -----RRPLP TMMFVNNVVV VLNNTLSSSW FY---GGKKK KKWQAERDEE APPEEEG--P -----RRPAP VYYFVGGVVV VVDDTLEEGW WR---GGKKK KKFHVKKTPP APPTTTADDE -----RRPAP VYYFVGGVVV VVDDTLEEAW WR---GGKKK KKFHAEKTPP PPPPPPKEEK -----RRPAP SYYFCGGVVV VVDDTLQQGF WQKKKGGTTT TTFEAKKTDD PPPDDDADDD -----RRPAP TYYFVNNCCV VISSLLSSSW YR---DDKKK KKWAVRKEPP AAADDDPDDQ -----RRPAP TYYFMNNCCV VVSSLLSSAW YR---GGSSS SSWHLKKDPP APPSSSEDDQ -----RRPAP AYYFVGGVVV VVSSLLSSAW HR---GGSSS SSWGIRKEPP APPEEEPDDQ ---LLRRFLP SQQFVGGCCA ALSSSQRRFN G--------- -------WVV EVVQQQVPPS ---LLRRFLP DQQFVGGCCA ALSSSQRRFN G--------- -------WVV EVVQQQVPPS ---LLRRFLP DQQFVGGCCA ALSSSQRRFN G--------- -------WVV EVVQQQVPPP ---LLRRFLP DQQFVGGCCA ALSSSQRRFN G--------- -------WAA QVVQQQVPPP ---LLRRFLP DQQFVGGCCA ALSSSQRRFN G--------- -------WVV EVVQQQVPPP ---LLRRFLP DQQFVGGCCA ALSSSQRRFN G--------- -------WVV EVVQQQVPPP ---LLRRFLP DQQFVGGCCA ALSSSQRRFN G--------- -------WVV EVVQQQVPPP ---LLRRFLP DQQFVGGCCA ALSSSQRRFN G--------- -------WVV EVVQQQVPPP ---LLRRFLP AQQFVGGCCA ALSSSQRRFN G--------- -------WVV EVVEEEVPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PIILLRRSIK NQQYDVVVVE EVSSFRGGGP Y--------- -------VLL KKKDDDLYYY ---LLRRFLP DQQLVGGCCA ALSSSFRRFE G--------- -------WAA EVVKKKVPPS ---LLRRFLP DQQLVGGCCA ALSSSFRRFE G--------- -------WAA EVVQQQVPPS ---LLRRFLP ATTFVGGSSA ALSSSIRRFT G--------- -------WHH EAAPPPVKKP ---LLRRFLP ATTFVGGSSA ALTTSIRRFT G--------- -------WHH EVVSSSVEEP ---LLRRFLP STTYVGGSSA ALSSSIRRFN D--------- -------WYY EVVSSSVKKP ---LLRRFLP STTFVGGSSA ALSSSIRRFN E--------- -------WHH EVVSSSVKKP ---LLRRFLP STTYVGGCCA ALTTSVRRFT G--------- -------WHH EAASSSIKKP ---LLRRFLP THHFVGGCCA ALGGSFRRIV NS-------- ------THAA TVVFFFIPPS ---LLRRFLP THHFVGGCCA ALGGSFRRID NP-------- ------KQAA SVVTTTIPPS ---------- ---------- ---------- ---------- ---------- ---------- ---LLRRFLP RQQYVGGCCA AFXXXXXXX- ---------- ---------- ---------- ---LLRRFLP KEEFVGGCCA ALNNAFHHFK SD-------- ------EAKK VDDPPPGKKL ---------- ---------- ---------- ---------- ---------- ---------- ---LLRRFPS NYYFSTTTTA ALTTSWLLID G--------- ---------- ---EEEWQQA ---LLRRCAE AYYFTSSTTA ALTTSWLLID G--------- ---------- ---EEEWQQA PPPEELKPPK KKKAVLTIDD ISLKKFYSLL WRQDIPPFPP VLTGKVGGIH RRDH------ PPPPPLKDDK KKKMVLTIDD ISLRRFYSLL WRQDIPPHPP RLAGRVGGLH RRPH------ PPPPPLQGGG GGGAVLTIDD LSLRRFYSCC WRQDVPPHPP VLAGSVGGIR RRPH------ PPPPPLQGGG GGGAVLTIDD LSMRRFYSCC WRQDVPPRPP KLAGSVGGIR RRPH------ PPPDDLKGGG GGGACLTIDD LSLKKYYACC WHQDVPPMPP VLTGKVGGIK KKPH------ PPPPPLKGGK KKKAVLTIDD LSMRRFYSCC WLQDVPPFPP KLTGKVGGIS RRTHG----- PPPPPLKPPK KKKAVLTINN LSVRRFYSCC WHQDVPPFPP RLTGKVGGIR RRGH------ PPPPPLKDDG GGGAVLTINN LSLRRFYSCC WRQDVPPFPP RHTGSVGGIR KKAH------ KKKVVGWMMP PPPEMLTILL LSLRRFYSNN WRQDIPPQPP RLTGQIGGSV RRGSQV-DQQ KKKVVGWMMP PPPEMLTILL LSLRRFYSNN WRQDIPPKPP RLTGQIGGSV KKGSQV-DQQ KKKVVGWMMP PPPEMLTILL LSLRRFYSNN WRQDIPPQPP RLTGQLGGSV KKGPQV-DQQ KKKVVGWMMP PPPEMLTILL LSLHHFYSNN WRQDVPPQPP RLTGQLGGSV KKGPQV-DQQ KKKVVGWLLP PPPEMLTILL LSLRRFYSNN WRQDIPPQPP RLTGQLGGSV KKGPQV-DQQ KKKVVGWLLP PPPEMLTILL LSLRRFYSNN WRQDIPPQPP RL-------- ---------- KKKVVGWLLP PPPEMLT--- ---------- ---------- ---------- ---------- KKKVVGWLLP PPPEMLTILL LSLRRFYSNN WRQDIPPQPP RLTGQLGGSV KKGPQV-DEE KKKVVGWMMP PPPEMLTILL LSLRRFYNNN WRQDIPPKPP RLVGQIGGSV KKGPQV-DQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVVVKFGGV VVVSLEPAWW IFFLLLILSS ---------- ---------- ---------- KKKVVGWAAP PPPEMLTILL ISLRRFYSNN WRQDIPPRPP KLVGQIGGSL RRGPTV-DKK KKKVVGWPPP PPPEMLTILL ISLRRFYSNN WRQDITTRPP KLVGQIGGSQ RRGPTV-DKK KKKVVNWIIP PPPEMLTFLL ISLRRFYVNN WRQNILLKPP VLTGQLGGLQ KKSPAA-EDD KKKVVNWFFP PPPEMLTFLL ISLRRFYVNN WRQNIVVKPP KLTGQVGGLQ KKSPVA-DDD KKKVVNWIIP PPPEMLTFLL ISLRRFYVNN WRQNIPPKPP VLTGQIGGLQ KKSPKA-EDD KKKVVNWIIP PPPEMLTFLL ISLRRFYVNN WRQNIPPKPP VLTGQIGGLQ KKSPKA-EDD KKKVVNWIIP PPPEMLTFVV ISLRRYYVNN WRQNIPPAPP VLAGQVGGLQ KKSEVY-EDD KKKVVGWAAP PPPEMLTILL ISMRRFYSCC WRQDIPPLVV KLNSQVGGSH TTSNKV-GEE KKKVVNWAAP PPPDMLTILL ISMRRFYSCC WRQDIPPKPP KLNSQVGGSH SSTTKV-EDD ---------- ---------- ---------- ---------- ---------- ---------- QQQGGNGEEE EEEMMMTILL ISLRRYYSNN WRQDIRRAPP RLTGQVGGAQ RRAPRV-DPP DDDTTSGVVE EEEDMMSIII ISLRRFYNCC WRQDIPPEPP KLTGQLGGAC SSLPVIEDKK ---------- ---------- ---------- ---------- ---------- ---------- AAAVVDIGGP PPPADLVISS IAAQQTWNSS FRLDIPPHPP FQIYEKDRQN ---------- AAAVVDIGGP PPPAKLVISS ISNSSRWNTT FRLDIPPHPP RQVYEKGAQN ---------- ---------- ----AAHHKK LLLTGAAPQQ MLEIGRVVVV VTTSSYYTTW DNQPGLKWVV ---------- ----SSAAEE AAATGAAPQQ MISVGRVVVI ITTSSYYSSW NNQPGLRWAA ---------- ----NNRRTT FFFAGGGPQQ MVEIGRVVVW WTTSSYYTTW DDQPGVPAVV ---------- ----NNKKAA FFFAAGGPQQ MVEIGRVVVW WTTSSYYTTW DDQPGVPVVV ---------- ----NNKKTT FFFGYGGPQQ MVEIGKVVVW WTTSSYYTTW DEQPDRGAVV ---------- ----KKGGAA LLLNGGGPQQ MVEIGRVVVF FTTSSYYAAV DPQPGIDWVV ---------- ----TTAAEE LLLNGGGPQQ MVEIGRVVVF FTTSSYYAAW DEQPGIKWVV ---------- ----AAGGPP LLLNGGGPQQ MVEVGRVVVF FSSSSYYSSW DEQPGIRWAA EELTTCQEEE PLVVKKKKRR IIIPGGGPQQ MIQLGKLLLA ATTSSYYDDW DKQ-DLIESS EELTTCQEEE PLVVKKKKRR VVVPGGGPQQ MIQLGKLLLV VTTSSYYAAW DKQ-NLIESS EELKKSQEEE PLVVKKKKKK VVVPGGGPQQ MIQLGKLLLV VTTSSYYAAW DKQ-DLIESS EELDDSQEEE PLVVKKKKQQ VVVAGGGPQQ MIQLGKLLLV VTTSSYYAAW DKQ-DLIESS EELKKSQEEE PLVVKKKKRR VVVAGGGPQQ MIQLGKLLLI ITTSSYYAAW DKQ-DLIESS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EELKKSQEEE PLVVKKKKRR VVVAGGGPQQ MIQLGKLLLI ITTSSYYAAW DKQ-DLIESS EELKKSQEEE PLVVKKKKRR VVVPGGGPQQ MIQLGKIIIV VTTSSYYDDW DKQ-DLIESS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDLEECQDDD PVIIKKKKKK VVVPGGGPQQ MIQLGKLLLV VTTSSYYKKW DKQ-DMIESS EELEECQDDD PVTTKKKKII IIIPGGGPQQ MIQLGKIIIV VTTSSYYIIW DKQ-DLLEAA GGKTTWQDDD VPEEQQQQKK LLLRGGGPQQ MIQLGKLLLV VTTSSFFAAW DKQ-GLVKSS GGETTWQDDD VPEEQQKKKK LLLRGGGPQQ MIQLGKLLLV VTTSSFFAAW DKQ-KLVQSS GGNSSFQDDD VPQQKKKKSS LLLRGGGPQQ MIQLGKLLLA ATTSSFFAAW DRQ-ELMKSS GGNTTFQEEE VPQQKKKKSS LLLRGGGPQQ MIQLGKLLLA ATTSSFFAAW VVS-EIMKSS DDKEEEQSSS VPQQKKHHRR LLLRGGGPQQ MIQLGKIIIV VTTSSFFRRW DEQGDLVKSS KK----PEEE ALYYKKRRKK IIIEGGGPQQ MLQLGKLLLV VTTSSYYKKW DDQ-EHVSAA HHD---EPPP ALYYKKRRQQ IIIEGGGPQQ MLQLGKLLLV VSSSSYYKKW DDQ-ENVSAA ---------- ---------- ----GGGPAA KIQLGKLLLV VTTSSYYTTW DKQ-NVVESS EELKKEAEEE PVFFKKRRRR LLLLGGGPQQ MLQLGRLLLV VSSSSFFPPW DKQ-EMVAGG EELKKERPPP ARYYKKRRRR LLLEGGGPQQ MLQLGKLLLV VSSSSYYPPW DKQ-KMVQGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MVSQGKVVVF FSSSSLLNNW D------KKK ---------- ---------- ---------- MVSSGQLLLY YTTSSLLNNW D------KKK KKLLNAA--P GGLLEEIDDD KKKEFFVG-- ------AAHH QVRLSGGDAS SDSYYYPP-- KKVVNVV--P GGLLEELEEE KKKEFFVG-- ------AAHH QVRLWGGDAS TDSYYYPP-- LLAAHAA--P GGLLTTLAAA DDDDYWVPGG ------YYHH QIRLEGGDCS TDSYYYPPVV MMAANVV--G GGLLEELDDD KKKDYFVPGG ------YYHH QIRLEGGDCS TDSYYYPPVV MMAANVV--E GGLLTTLDDD KKKDFWVPGG ------YYHH QIRLEGGDCS TDSYYYPPVV KKLLDAA--P GGIIEEFDDD PPPKFFLPGG ------HHHH QVRLQGGDCS SDSYYYPP-- KKVVDVV--P GGMMQQFDDD PPPNFFVG-- ------QQHH QIRLQGGDAS SDSFFFPP-- KKAAEAA--P GGLLSSLDDD PPPGFFTGGG ------LLHH QIRLEGGDSS SDSYYYPP-- VVMMLQQDTV GGLLKKLNNN PPPNFLVGEE PLGGGPAAHH ELRYPGGDCS SDI------- VVMMLQQDTA GGLLKKLNNN PPPNFLVGEE PLGGGPAAHH ELRYPGGDCS SDI------- VVMMLQQDTV GGLLKKLNNN PPPNFLVGEE PLGGGPAAHH ELRYPGGDCS SDI------- VVMMLQQDTV GGLLTTLNNN PPPNFLVGEE PLGGGPAAHH ELRYPGGDCS SDI------- VVMMLQQDTV GGLLKKLNNN PPPNFLVGEE PLGGGPAAHH ELRYPGGDCS SDI------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVMMLQQDTV GGLLKKLNNN PPPNFLVGEE PLGGGPAAHH ELRYPGGDCS SDI------- VVMMLQQDTV GGLLKKLNNN PPPNFLVGEE PLGGGPAAHH EIRYPGGDCT SDI------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVMMLQQDTE GGLLKKLNNN PPPNFLVGEE PGGGGPVVHH ELRYPGGDCS SDI------- VVMMLQQDTK GGLLKKLNNN PPPNFLVGEE PDGGGPVVHH EIRYPGGDCT SDI------- HHIILQQDTE GGLLKKINNN PPPNFFVGEE PDGGGPAAHH EMRYPGGDCT SDI------- HHIILQQDTE GGLLKKINNN PPPNFFVGEE PDGGGPSSHH EMRYPGGDCT SDI------- HHIIIQQDTE GGLLSSINNN PPPNFFVGEE PEGGGPAAHH EMRYPGGDCT SDI------- HHIIIQQDTE GGLLTTINNN PPPDFFVGEE PDGGGPSSHH EMRYPGGDCT SDI------- HHMMLQQDTE GGLLSSINNN PPPNFFVGEE PEGGGPSSHH EMRYPGGDCT SDI------- TTMMVQQDPE GGMMEEINNN RRRDFLIGII EGGGGPYYHH EMRYPGGDCT SDI------- TTMMLQQDPI GGMMVVINNN KKKNFLIGVV PGGGGPYYHH EMRYPGGDCT SDI------- VVMMLQQDTE GGLLTTVNNN KKKNFLVGEE PNGGGPCCHH DIRFPCGDST SDI------- TTIIVQQDVE GGMMKKLNNN EEENFLVGEE PYGGGPGGHH EMR------- ---------- HHIIVLLDTV GGIISSLNNN EEEDFLVAEE PYGGGPSSHH EMRYPGGDCT SDIAAANNAA ---------- ---------- ---------- ---------- ---------- ---------- DDDDAQQAYN DDKKEELVVV EEEDFAVYLL GLGGG---HH IMRFGSSALY SS-------- DDDDEQQLYY DDKKEELKKK EEEQFAIYEE KLGGG---HH QMRFGARALY AGPDDDGGRR ------- ------- VVKKR-- VV----- VV----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AA----- ------- ------- RRLLVVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NAKKKKKQQP SAPCCRAVLL AAARLAADDD GAAMMMLPRT TTTLLLLSLL GPPPVRKKKY gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------M gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YQEAAAAWTS SSAAQQQVLS SSSSSKKKKT VVVVPPGLVE ISSSAKKVVP SSQAAVVVVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MAGRRSSAPL LPPPNNNNRP PTTPPLLLAS HHHHPPRVPL TRLLPYYTIN VVPPRLLLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM AIVVPPPFFA AAMMKKAPEE ---------- ---------- ---------- ---------- -MAAKKKLLA AAMMRRAPEE ---------- ---------- ---------- ---------- --MMSSSMMA AAMMQQAAEE ---------- ---------- ---------- ---------- --MMTTTMMA AAMMEEAAEE ---------- ---------- ---------- ---------- --MMTTTLLA AAMMEEGVEE ---------- ---------- ---------- ---------- -MAATTTWWA AAAAKKAPEE ---------- ---------- ---------- ---------- -MVVTTTWWA AAVVKKAAEE ---------- ---------- ---------- ---------- -MAASSSWWA AAMMQQAREE ---------- ---------- ---------- -----MAATT KCTTKKK--M MMKK--GREE ---------- ---------- ---------- ---------- ---------- --MM--GREE AAWPPPGHGA AVLLIIPPPA RGLLLLLGG- ----AHSSTT QCGGKKK--M MMKK--GREE ---------- ---------- ---------- ---------- ---------M MMKK--GREE ---------- ---------- ---------- -----MAATT KCGGNNN--M MMKK--GREE ---AAEREGA FTLLQQVVVA QPMMMMRIIA AAAASTAATT KCGGNNN--M MMKK--GREE ---------- ---------- ---------- -----MAATT KCGGNNN--M MMKK--G--- ---------- ---------- ---------- -----MAATT KCGGNNN--M MMKK--GREE --GGGKEPGH TAQQPPFFFL SGQQQQLQQE EEEEDTAATT KCGGDDD--M MMKK--GREE LLNQQGCGFD QTNNTTLLLH TYCCCCTVVF FFFFTSPPTT KCGGNNN--M MMKK--GREE ---------- ---------- ---------- -----MAATT KCGGNNN--M MMKK--GREE PPHRRHSVLQ HIMMEEAAAA AVEEEETAAA AAAAANGGKK TCCCHHHTTM MMEEKKGREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMAA KCGGSSS--M MMKK--GREE ---------- --MMAAVVVL DHGGGGVNNE EEEEKKSS-- VNGGCCCCCM MMSS--GREE ---------- --MMGGVVVL QHAAAAVSSE EEEEKVNNNN QQGGCCCCCM MMSS--GREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -RMMLLLQQM MMSS--GSEE ---------- ---------- ------MAAA AAAAANGGAA ACCCGGGGGM MMEEKKGREE ---------- ---------- -------SSP PPPPNCGGLL KCHHGGG--I IIKK--GREE ---------- ---------- -------PP- -----CPPLL KCHHGGG--I IIKK--GREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM SESSKKKCCV VVRRNNGVEE ---------- ---------- ---------- ---------- ---------M MMRRSSGREE ---------- ---------- ---------- ---------- ---------L LLIISSLDRR ---KKRRFG- ---------- -ALLLLAGG- ----ALAAMM GLPPFFFRRP PPKKIITQEE ---KKRFVSG PSMMHHAAAL RALLLLVGGL LLLLALAALL AAPPAAAGGK KKKKIITQEE DDAYVVACLL YTGGGNAADF FVVNPKKIHK ELLPYYYNNN DLHFFWWWCC SSALCCCC-P DDAYVVAALL YVGGGNPPDF FVVDPKKVYK DLLPYYYGGG DLHFFWWWCC SSAYCCCC-P EEAYTTLLLL SPDSS-PPDA AVVKPGKIHT TMMPNNNGGG DFHFFWWWCC SSSLSSSS-P NNAYTTLLLL SPDSS-PPDA AVVKPGQIHT TMMPNNNGGG DFHFFWWWCC SSALSSSS-P KKAFTTLMLL SPDSS-PPDG GVVDPTQIHQ IMMPNNNGGG DFHFFWWWCC SSALSSSS-P TTAYVVAMFF DPEKK-PPDA AVVDPASIGQ AMMPHHHGGG DLHFFWWWCC SSCLCCCC-P KKAYVVVRLL NPMNN-PPDA AVVDSQQVGV DMMPYYYGGG GLHFFWWWCC SSMLCCCC-P RRGYVVALLL DPGEE-PPDA AVVDPDQIGR EMMPNNNAAA DLHFFWWWCC SAALCCCC-P EEVYLLPCII YRNGGEPPDY YTTDPKQVHR PMMPYYYKKK DLHSSWWWCC SSC------- EEVYLLPCII YRNGGEPPDY YTTDPKQVHR PMMPHHHKKK DLHSSWWWCC SSC------- EEVYLLPCII YGNGGEPPDY YTTDPKQVHR PMMPNNNRRR DLHSSWWWCC SSC------- EEIYLLPCII YRNGGEPPDY YTTDPKQVHR PMMPHHHKKK DLHSSWWWCC SSC------- EEVYLLPCII YRNGGEPPDY YTTDPKQVHR PMMPNNNKKK DLHSSWWWCC SSC------- EEVYLLPCII YRNGGEPPDY YTTDPKQVE- ---------- ---------- ---------- ---------- -----EPPDY YTTDPKQVHR PMMPNNNKKK DLHSSWWWCC SSC------- EEVYLLPCII YRNGGEPPDY YTTDPKQVHR PMMPNNNKKK DLHSSWWWCC SSC------- EEVYLLPCII YRNGGEPPDY YTTDPKQVHR PMMPYYYKKK DLHSSWWWCC SSC------- EEVYLLPCII YRNGGEPPDY YTTDPKQVHR PMMPNNNKKK DLHSSWWWCC SSC------- EEVYLLPCII YRNGGEPPDY YTTDPKQVHR PMMPNNNKKK DLHSSWWWCC SSC------- KKVYVVTCVV YNGGGNLLDY YTTDPSQVHR PVVIHHHGGG DLHSSWWWCC SSC------- ---------- ---------- ---------- -MMPNNNNNN DLHSSWWWCC SSC------- EEVYLLPCII YRSGGNPPDY YTTDPKQVHR PMMPNNNNNN DLHSSWWWCC SSC------- SSIYVVTAVV YAGGGEPPDY YTTDPSKVHR PVVPYYYGGG DLHTTWWWCC SSC------- TTIYVVTAVV YAGGGEPPDY YTTDPNKVHR PVVPYYYGGG DLHTTWWWCC SSC------- ---------- ---------- ---------- -MMPFFFGGG DLHSSWWWCC SSC------- KKIYVVTAVV YTGGGDPPDY YTTDPSSVHR PMMPFFFGGG DLHSSWWWCC SSC------- KKLYVVTCVV YNGGGNPPDY YTTDPNQVHR PVVTHHHGGG DLHSSWWWCC SSC------- EELFVVTAPP ---AADPPDA ATTNPEQVSR DVVPHHHGGG DVHTTWWWCC SSC------- EELFVVTAPP ---AADPPDA ATTNPEQISR DVVPNNNGGG DVHTTWWWCC SSC------- ---------- ---------- ---------- ---------- ---------- ---------- KKLYVVVCVV QPNDDEGGDY YTTDPAQVHR YTTNSSSHHH NLHSSWWWCC SSCHFFFFVP KKLYTTVTVV QPNDDPGGDY YTTDPEQIHR FTTNRRRGGG DLHSSWWWCC SSCYYYYYVD FFYFSSNWLL HGDRRYIITD DNNVGQSVKD PVVKVVVEEE DEDSSPPPRR ILK------- EEVYVVWTLL GVEMMDQQDK KTTRPGQVNS SVVGGGGRRR NAHGGFFF-- ---------- DDVYVVWTLL GAEVVDQQDK KTTNPKKVNT SVVGGGGRRR NAHSSFFF-- ---------- NN--KKKKPP PNNIEERRFV PPSSSSRIIY YIIDKPEEPI IIIIKVIPPE EEKKKKVSSG NN--KKKKPP PFFLEERRYV PPSSSSRIIY YIIDKPRRPV AAAAKIVPPV VVVVGGRTTG LLGGHHHHAA AFFLEERRFI PPSSSSRIIY YVVDKPQQAI HHHHKIIPPE EELLAAKTTG LLGGHHHHAA AFFIEERRYI PPSSSSRIIY YIIDKPKKAI HHHHKIIPPE EEFFKKKTTG LLGGHHHHAA AFFLEERRYI PPSSSSRIIY YIIDK-KKAI HHHHKIIPPE EEFFAAKTTG NNPPHHHHPP PHHMEERRYV PPSSSSRIIY YIIDKPKKPL AAAAKVIPPT TTAAEERTTG NNPPHHHHPP PHHVEERRYV PPSSSSHIIT TIIDKPQQPV VVVVKVIPPE EEAAEERTTG YYPPHHHHPP PHHVEERRYV PPSSSSRIIH HIIDKPEEPI VVVVKVIPPE EEHHRRRTTG --GGDDDDSS STTKSSNNKL PPSSSSRIIY YVVDGSAAPL HHHHKVIAAE EEQQAAKCCN --GGDDDDSS STTKSSDDKL PPSSSSRIIY YVVDGSAAPL HHHHKVIPPE EEHHAAKCCN --GGDDDDSS STTKSSTTKL PPSSSSRIIY YVVDGSAAPL HHHHKVIAAD DDHHAAKCCG --GGDDDDII ITTKAATTKL PPSSSSRIIY YVVDGTAAPL HHHHKVIPPD DDHHTTKCCN --GGDDDDSS STTKSSTTKL PPSSSSRIIY YVVDGSAAPL HHHHKVIPPD DDHHAAKCCE ---------- ---------- ---------- ---------- -------PPD DDHHAAKCCE --GGDDDDSS STTKSSTTKL PPSSSSRIIY YVVDGSAAPL HHHHKVIPPD DDHHAAKCCE --GGDDDDSS STTKSSTTKL PPSSSSRIIY YVVDGSAAPL HHHHKVIPPD DDHHAAKCCE --GGDDDDSS STTKSSNNKL PPSSSSRIIY YVVDGTAAPL HHHHKVIAAD DDHHEEKCCG --GGDDDDSS STTKSSTTKL PP-------- ---------- ---------- ---------- --GGDDDDSS STTKSSTTKL PPSSSSRIIY YVVDGSAAPL HHHHKVIPPD DDHHAAKCCE --GGDDDDPP PSSAKKRRFL PPSSSGRVVY YVVDATTTPL HHHHKVVSSD DDAAEENIIG --GGDDDDAA ASSKVVNNKL PPSSSSRIIY YVVDGTAAPI HHHHKTVPPE EEFFWWKCCG --GGDDDDSS SSSKVVNNKL PPSSSSRIIY YVVDGSAAPI HHHHKTVPPE EEFFWWKCCG --GGDDDDPP PSSAEERRFA PPSSSGRIIY YVVDKTSSPL HHHHKVVPPD DDIIQQKTTG --GGDDDDPP PSSAQQRRFV PPSSSGRVVY YVVDKTAAPL HHHHKVVPPD DDSSTTKTTG --GGDDDDAA ASSADDRRYL PPSSSGRIIY YAADKEAAPL YYYYKYVPPE EEAAEEKTTG --GGDDDDAA ASSVDDRRYL PPSSSGRIIY YAADKEAAPL YYYYKYVPPE EEAADDKTTG --GGDDDDPP PSSASSRRFL PPSSSGRVVY YVVDLKAAPL HHHHKVVAAD DDAAEEKTTG --DDKKKKPP PTTEKKSSHV PPSSSDRIIY YIINENKKIL EEEEHTIPPK KKHHSSLNN- --DDKKKKPP PTTEKKSSHV PPSSSDRIIY YVVNENEEIL QQQQHTIPPK KKHHAALNN- ---------- ---------P RRSSSGVEEG GKKFGG---- ---------- ---------- --GGKKKKEE EVVPTTDDRL PPSSSDRIIF FVVDGTAAPL AAAAKVIGGD DDLLKKGAAD EESSKKKKTT TVVPKKDDRL PPSSSDFIIY YIIDVTKKPI VVVVKTIGGD DDLLKKSHHN --GGKKKKRR RVVQGGPPQQ LLGGGKRLLY YVVTLYDDKF YYYYP----D DDIIKKFLLV ---------- ----DDRRFT GGTTTNRIIF FIIDHSNNPL HHHHKTITTF FFKKDDSGGG ---------- ----DDRRYA GGTTTSKIIF FVVDHSRRPL SSSSKTIDDF FFEEKKSGGG YSRLHVHCCC GPDAYISSSA GNNEG--EGG GPGMDYYSFF FEGGGKKIDR Y--------- YTKYHVHCCC GPDAYISSSA GGGPGRREGG GPGLDDDTFF FEGGGRRVYR Y--------- YSRPHVHCCC GPEGYVSSST GGGAGTTDGG GAGIDEETFF FDGGGRRIDR D--------- YSRPHIHCCC GPDGYVSSST GGGGGTTNGG GPGIDEETFF FEGGGRRIDR T--------- YSRPHIHCCC GPEGYVSSST GGGGGTTDGG GPGIDEETFF FEGGGRRMDR T--------- YSRPHVHCCC GPGGYVTTTA GNNAG--KGG GPGMDQQSFF FEGGGRRVER Y--------- YARPHVHCCC GPDGYISSSA GSSPG--EGG GPGIDDDNLL LEGGGRRIDR Y--------- YSRPHIHCCC GPDGYVSSSA GSSPG--DGG GPGVDEESFF FDGGGRRVER Q--------- VSNTHSHCCC LASGVMVVVN LGGDQGGNGG GKSLDEETFF FEGGGTTKPG P--------- LGNLHSHCCC LASGVMIIIS LGGDQGGNGG GKGLDEETFF FEGGGTTKPG P--------- LGYVHSHCCC LASGVMIIIS LGGDKGGNGG GKGLDEETFF FEGGGTTQPG P--------- LGFFHSHCCC LPSGVMVVVS LGGDEGGNGG GKGLDKKTFF FEGGGTTQPG P--------- LAFLHSHCCC LASGVMIIIS LGGDKGGNGG GKGLDEETFF FEGGGTTRPG P--------- LAFLHSHCCC LASGVMIIIS LGGDKGGNGG GKGLDEETFF FEGGGTTRPG P--------- LAFLHSHCCC LASGVMIIIS LGGDKGGNGG GKGLDEETFF FEGGGTTRPG P--------- LAFLHSHCCC LASGVMIIIS LGGDKGGNGG GKGLDEETFF FEGGGTTRPG P--------- LGTPHSHCCC LPTGVMIIIS LGGDKGGNGG GKGLDEETFF FEGGGTTRPG P--------- ---------- ---------- ---------- ---------- ---------- ---------- LAFLHSHCCC LASGVMIIIS LGGDKGGNGG GKGVL--RLL LEGGG----- ---------- LGFPHSHCCC LASGIMIIIS LGGDEGGNAA AANLLSSEFF FNGGGRRNRL S--------- LANLHSHCCC LGCGIMIIIS IGGDYGGNGG GKGLDEETFF FEGGGNNAEG P--------- LANPHSHCCC LGCGIMIIIS LGGDCGGNGG GKGLDEETFF FEGGGNNVEG Q--------- LAYPHSHCCC LASGLMIIIS LGGDDGGNAA AENLLSSDFF FNGGGRRKPG L--------- LAYPHSHCCC LASGIMIIIS IGGDDGGNAA AENLLSSEFF FNGGGRRKPG L--------- LAYPHAHCCC LASGILVVVS LGGDEGGNAA AKNLLSSDFF FNNNNRRKPG L--------- LAFPHAHCCC RT-GILVVVS LGGDEGGNAA AKNLLSSDFF FNNNNRRKPD L--------- LGFPHSHCCC LASGIMIIIS LGGDEGGNAA AANLLSSEFF FNGGGRRKPG L--------- LSFPHSHCCC LADGIMIIIS LGGENGGTPP PSNLDKKTFF FEGGGTTADE P--------- LSFPHSHCCC LADGIMIIIS LGGEDGGSPP PSNLDKKTFF FEGGGTTADG P--------- ---------- ---------- ---------- ---------- ---------- ---------- CTAPHTHCCC LPNGIMIIIS MGGDEGGNAA AK-VFKKNFF FEGGGTTRGD L--------- VTAPHTHCCC LANGIMIIIS MGGDEGGYAA AK-IFSSDFF FNGGGTTKGD L--------- LAISHADYYY QPNTLKQQQD VNNELSSVPP PVNQSHHENN NGAAAKKASQ I--------- VVGPHFFAAA LPGSMITTTG SNNDDHHGGG GRAENDDGEE EYTTTYYPTA QGAVVAGGDD VVGPHLYAAA LPGRLITTTG SNNNDHHGGG GRAETAAGEE EYTTTHHPTD RGAIIKGG-- ---AAAYFWW NLPPLLLVSW WAPPP---IE -LKLEEKKD- RRRGGGNRRR RRFWDDRKKK ---AAAYFWW NLPPMMMITW WTPPP---FE -FSLEEKKEG AAAGGGNKKK KKVWDDAKRR ---HHHYFWW NLPPMMMVSW WAPPP---FE -IVPEELLAN KKKGGGHRRR RRFWDDRARR ---HHHYFWW NLPPMMMVTW WAPPP---FE -IVPEELLSN KKKGGGHRRR RRFWDDRARR ---HHHYFWW NLPPMMMVSW WGPPP---FE -IVPEELLSN KKKGGGHKKK KKFWKKRDKK ---AAAYGWW HLGGLLLVTW WGPPP---VE -LVPDDLLGA RRRGGGRRRR RRFWDDTRRR ---HHHYFWW HLGGLLLLTW WGPPP---VE -VLGDDLLAG KKKGGGHRRR RRVWDDYRRR ---AAAYFWW HLGGMMMVTW WGPPP---IE -LDPQQLLNK GGGGGGRRRR RRIWDDRRRR ---GGGYFYY QPRRMMMVSW WAPPP---FK FNPAHHAA-G LLLGGGSRRR RRVWDDQREE ---GGGYFYY QPRRMMMVSW WAPPP---FK FNPAHHAA-G LLLGGGSHHH HHVWDDQREE ---GGGYFYY QPRRMMMISW WAPPP---FR FNPADDAA-G LLLGGGSHHH HHVWDDQREE ---GGGYFYY QPRRMMMISW WAPPP---LR FNPADDAA-G LLLGGGSHHH HHVWDDQREE ---GGGYFYY QPRRMMMISW WAPPP---LR FNPADDAA-G LLLGGGSHHH HHVWDDQHEE ---GGGYFYY QPRRMMMISW WAPPP---LR FNPADDAA-G LLLGGGSHHH HHVWDDQREE ---GGGYFYY QPRRMMMISW WAPPP---LR FNPADDAA-G LLLGGGSHHH HHVWDDQREE ---GGGYFYY QPRRMMMISW WAPPP---LR FNPADDAA-G LLLGGGSHHH HHVWDDQREE ---GGGYFYY QPRRMMMISW WAPPP---VQ FNPADDAA-G LLLGGGKHHH HHVWDDQREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------S SASSS---RL SRDYPPAA-S RRRAAAGIII II-------- ---EEERHYY ENAAFFFWSQ QCSSS---YT AELMCCAA-S GGGHHHVIII IILDNNIMVV ---GGGYFYY QPRRMMMISW WGPPP---FA FKMEEEAA-G MMMGGGHSSS SSVWDDTERR ---GGGYFYY QPRRMMMISW WGPPP---FA FKMEDDAA-G HHHGGGHSSS SSVWDDTERR ---GGGYFYY QPRRMMMISW WGPPP---FT FDLQHHDD-G LLLGGGRHHH HHCIQQAREE ---GGGYFYY QPRRMMMISW WGPPP---FL FNLQHHDD-G LLLGGGRHHH HHVYSSPGEE ---GGGYFYY QPRRMMMISW WGPPP---FS FDLQHHDD-G LLLGGGSHHH HHVYSSPGEE ---GGGYFYY QPRRMMMISW WGPPP---FS FNLQHHDD-G LLLGGGSHHH HHVYSSPGEE ---GGGYYYY QPRRMMMISW WGPPP---FR FDLQHHDD-G LLLGGGRHHH HHVYDDPGEE ---NNNYFYY QPRRMMMISW WGPPP---IK FNPAHHEE-G LLLGGGNSSS SSIFEEDSKK ---NNNYFYY QPRRMMMISW WGPPP---IK FNPAHHEE-G LLLGGGNSSS SSIFEEDTKK ---------- --------SR RGPPP---VC EELKCCEE-P LLLIIIKCCC CCVY------ ---GGGYYYY QPHHMMMVAW WGPPP---FR YHPTDDDDRT QQQGGGCRRR RRFYRRQEEE ---GGGYFYY QPYYMMMVSW WGPPP---WR WKNVDDDDMS QQQGGGCRRR RRFYKKSTTT ---QQQLNNN NG--SSSESP PDPPP---AF SESFLLTTGP LLLPPPQHHH HHEVLL---- AVAGGGYIAA LIRRMMMLTF FTWWWYYYMD QMLQDDAAMK RRRGGGNTTT TTQWDDHTQQ KYADDDYVAA LPRRLLLVTF FTWWWYYYMD KMLADDAAMK HHHGGGNTTT TTTWDDHTQQ KIISLTLGGE AAAAL----- --LPHPPTTM MGNNKKKDSS SSSWLWFYYY Y-EENKKIIP RLLAIDLGGQ VVVVL----- --VPHPPTTM MGNNKKKDSS SSSWLWFYYY Y-EEQRRIIE RVVTIDLGGA AAAAL----- --VPHPPVVY YGGGTTTNEG GGGWTWWRRR R-EEHKKAIP RVVTIDLGGA AAAAL----- --VPHPPVVY YGGGTTTNEA AAAWTWWRRR R-EEHKKAIP KVVTIDLGGA AAAAL----- --IPHPPSSY YGGGTTTNQG GGGFTWWQQQ QKDDEKKIID RLLEIDFGGD VVVVF----- --LPHPPTTY YGNNKKKDSS SSSWTWYRRR R-DDAKKIIP RLLTLDLGGA AAAAL----- --LPHPPTTY YGNNKKKDSA AAAWLWYRRR R-DDHKKIIP RLLALDVGGE VVVVL----- --LPHPPAAY YGGGEEEDSA AAAWLWHRRR R-QQGKKIIP EIITLQMTT- IIIIP----- LLIFHPPSSQ QGGGNNNIRF FFFNEEG--- -------TSV EIITLQMKK- IIIIP----- LLIFHPPDDQ QGGGNNNIRF FFFNEGG--- -------TSV EIITLTLQQ- IIIIP----- LLIFHPPDDQ QGGGTTTIRF FFFNQGG--- -------TSV EVVTLPLQQ- IIIIP----- LLIFHPPDDQ QGGGTTTIRF FFFNEDG--- -------TSA EVVTLSLKK- IIIIP----- LLIFHPPDDQ QGGGTTTIRF FFFNEGG--- -------TSV EVVTLSLKK- IIIIP----- LLIFHPPDDQ QGGGTTTIRF FFFNEGG--- -------TSV EVVTLSLKK- IIIIP----- LLIFHPPDDQ QGGGTTTIRF FFFNEGG--- -------TSV EVVTLSLKK- IIIIP----- LLIFHPPDDQ QGGGTTTIRF FFFNEGG--- -------TSV EVVTLLMPP- IIIIP----- LLIFHPPAAQ QGGGTTTIRF FFFNEGG--- -------TSV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VDDSLPLQQ- GGGGANNNII LLLSHKKNNQ QDVVSSSGGG GGGPDAY--- -------AVL RIITIDLGGE IIIIP----- LLIFHPPDDQ QGGGTTTVRF FFFEKDG--- -------KAA RVVTIDLGGK IIIIP----- LLIFHPPDDQ QGGGSSSIRF FFFEKDG--- -------KAA ERRTLDLGGN LLLLP----- LLIFHPPAAT TGGGNNNMRF FFFTQDG--- -------SSH EKKTLDLGGD LLLLP----- LLIFHPPAAT TGGGNNNMRF FFFTQDG--- -------SNH EKKLIDLGGE LLLLP----- LLIFHPPSST TGGGNNNMRF FFFNSDD--- -------TSY EKKLIDLGGP LLLLP----- LLIFHPPSST TGGGNNNMRF FFFNSDE--- -------TSH EKKTLDLGGS LLLLP----- LLVFHPPSST TGGGNNNMRF FFFTADG--- -------SSH KLLTIDLPPQ LLLLP----- LLVFHPPTTH HAGGGGGIRI IIIVEENSSS S----TTTAA KLLTIDLPPM LLLLP----- LLVFHPPTTH HAGGAAAIRI IIIDEKNPPP P----KKVTA ---------- ---------- ---------- ---------- ---------- ---------- EFFTIDLGGD TTTTP----- LLIFHPPRRQ QGGGXXXXXX XXX------- ---------- TYYTIDLGGS TTTTP----- LLIFHPPKKE EGGGKKKVHF FFFKSDSDDD D----EEEKK ---------- ---------- ---------- ---------- ---------- ---------- QKKVFNVPPG ---------- LLIFWSSNNY YATTQQQLLI IIIDDAG--- ---------- QKKVFDVPPG ---------- LLICWEEAAY YCSSQQQLLI IIIDGEG--- ---------- PPAEEG--NL PPPEILKKKF KPPLTTTDDI SLLDDKKKLL GGGGVVRRDP PPGGKVLLGG EEAQQG--PL PPPPVLKKKF KPPLTTTDDI SLLDDRRRVV GGGGLLRRDP PPGGRVIIGG PPAEEADDEL PPPPLLQQQF GPPLTTTDDL SLLDDRRRVV GGGGMMRRDP PPGGSVIIGG PPPEEKEEKL PPPPLLQQQF GPPLTTTDDL SMMDDRRRVV GGGGMMRRDP PPGGSVIIGG DDPVVADDDL PPPDLLKKKF GPPLTTTDDL SLLDDKKKVV GGGGMMHHDP PPGGKVIIGG PPAEEPDDQL PPPPVLKKKF KPPLTTTDDL SMMDDRRRVV GGGGLLLLDP PPGGKVIIGG PPAEEEDDQL PPPPILKKKF KPPLTTTDNL SVVDDRRRVV GGGGLLHHDP PPGGKVIIGG PPAEEPDDQL PPPPLLKKKF GPPLTTTDNL SLLDDRRRVV GGGGLLRRDP PPGGSVLLGG VVEKKVPPSK KKKVKGWWWL PGGLTTTDLL SLLDDRRRFF LGGGIIRRDP PPGGQILLGG VVEKKVPPSK KKKVKGWWWL PGGLTTTDLL SLLDDRRRFF LGGGIIRRDP PPGGQILLGG VVEKKVPPPK KKKVKGWWWL PGGLTTTDLL SLLDDRRRFF LGGGLLRRDP PPGGQLLLGG AAQKKVPPPK KKKVKGWWWL PGGLTTTDLL SLLDDHHHFF LGGGIIRRDP PPGGQLLLGG VVEKKVPPPK KKKVKGWWWL PGGLTTTDLL SLLDDRRRFF LGGGLLRRDP PPGGQLLLGG VVEKKVPPPK KKKVKGWWWL PGGLTTTDLL SLLDDRRRFF LGGGLLRRDP PP-------- VVEKKVPPPK KKKVKGWWWL PGGLTTT--- ---------- ---------- ---------- VVEKKVPPPK KKKVKGWWWL PGGLTTTDLL SLLDDRRRFF LGGGLLRRDP PPGGQLLLGG VVEKKVPPPK KKKVKGWWWL PGGLTTTDLL SLLDDRRRFF LGGGMMRRDP PPGGQILLGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLKRRLYYYA VVVVAKFFFV VNNEPPPPWI FFFDDLLLFF ---------- ---------- AAEKKVPPSK KKKVEGWWWL PGGLTTTDLI SLLDDRRRFF LGGGIIRRDP PPGGQILLGG AAEKKVPPSK KKKVEGWWWM PGGLTTTDLI SLLDDRRRFF LGGGIIRRDP PPGGQILLGG HHELLVKKPL KKKVQNWWWL PGGLTTTDLI SLLDDRRRFF LGGGIIRRNP PPGGQLVVGG HHEIIVEEPL KKKVQNWWWL PGGLTTTDLI SLLDDRRRFF LGGGIIRRNP PPGGQVAAGG YYEIIVKKPL KKKVENWWWL PGGLTTTDLI SLLDDRRRFF LGGGIIRRNP PPGGQIVVGG HHEVVVKKPL KKKVENWWWL PGGLTTTDLI SLLDDRRRFF LGGGIIRRNP PPGGQIVVGG HHEVVIKKPL KKKVRNWWWL PGGLTTTDVI SLLDDRRRLL LGGGIIRRNP PPGGQVAAGG AATLLIPPSK KKKVSGWWWL PAALTTTDLI SMMDDRRRVV LGGGIIRRDV VVSSQVIIGG AASLLIPPSK KKKVENWWWL PAALTTTDLI SMMDDRRRVV LGGGIIRRDP PPSSQVIIGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQQGENGGGI EGGMTTTDLI SLLDDRRRFF RGGGVVRRDP PPGGQVLLGG KKVIIGKKLV DDDTGSGGGA EGGMSSSDII SLLDDRRRVV RGGGVVRRDP PPGGQLLLGG ---------- ---------- ---------- ---------- ---------- ---------- -----WQQAK AAAVADIIIN PPPLVVVDSI AAADDQQQII MGGGTTRRDP PPYYEKIIDD -----WQQAK AAAVADIIIE PPPLVVVDSI SNNDDSSSVV MGGGTTRRDP PPYYEKIIGG GGGIFHHRRR PP-------- ---------- --AHHKLTGA QQLESDDGRY VTTTTLYTTW GGGLYHHRRR PP-------- ---------- --SAAEATGA QQISSDDGRY ITTTTLYSSW GGGIARRRRR PP-------- ---------- --NRRTFAGG QQVESDDGRY WTTTTLYTTW GGGIARRRRR PP-------- ---------- --NKKAFAAG QQVESDDGRY WTTTTLYTTW GGGIVKKKKK PP-------- ---------- --NKKTFGYG QQVESDDGRY WTTTTLYTTW GGGIVSSRRR PP-------- ---------- AAKGGALNGG QQVESDDGRY FTTTTLYAAV GGGIVRRRRR PP-------- ---------- AATAAELNGG QQVESDDGRY FTTTTLYAAW GGGIVRRKKK PP-------- ---------- --AGGPLNGG QQVESDDGRY FSSSSLYSSW GGGSIVVRRR VVVLLLE--D QQQETQPEEV VVKKKRIPGG QQIQSDDGRY ATTTTLYDDW GGGSIVVKKK VVVLLLE--D QQQETQPEEV VVKKKRVPGG QQIQSDDGRY VTTTTLYAAW GGGSIVVKKK VVVLLLE--D QQQEKQPEEV VVKKKKVPGG QQIQSDDGRY VTTTTLYAAW GGGSIVVKKK VVVLLLD--D QQQEDQPEEV VVKKKQVAGG QQIQSDDGRY VTTTTLYAAW GGGSIVVKKK VVVLLLE--D QQQEKQPEEV VVKKKRVAGG QQIQSDDGRY ITTTTLYAAW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGSIVVKKK VVVLLLE--D EEEEKQPEEV VVKKKRVAGG QQIQSDDGRY ITTTTLYAAW GGGSIVVKKK VVVLLLE--D QQQEKQPEEV VVKKKRVPGG QQIQSDDGRY VTTTTLYDDW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGSILLRRR VVVLLLE--D KKKDEQPDDI VVKKKKVPGG QQIQSDDGRY VTTTTLYKKW GGGSIQQRRR VVVLLLE--D KKKEEQPDDT VVKKKIIPGG QQIQSDDGRY VTTTTLYIIW GGGLIQQKKK VVAIIIG--E DDDGTQSDDE IIQQQKLRGG QQIQTDDGRY VTTTTLFAAW GGGLIQQKKK VVAVVVK--D DDDGTQSDDE IIQKKKLRGG QQIQSDDGRY VTTTTLFAAW GGGLLQQKKK VVAVVVG--E DDDGSQFDDQ IIKKKSLRGG QQIQSDDGRY ATTTTLFAAW GGGLLQQKKK VVAVVVG--E DDDGTQFEEQ IIKKKSLRGG QQIQSDDGRY ATTTTLFAAW GGGLLQQKKK VVYVVVT--E DDDDEQYSSQ VVKHHRLRGG QQIQSDDGRY VTTTTLFRRW GGGSVHHTTT VVVLLLE--G EEEK-PIEEY VVKRRKIEGG QQLQSDDGRY VTTTTLYKKW GGGSIHHSSS VVVLLLE--E DDDH-EIPPY VVKRRQIEGG QQLQSDDGRY VSSSSLYKKW ---------- ---------- ---------- --------GG AAIQSDDGRY VTTTTFYTTW GGGAIQQRRR RRVLLLN--D PPPEKAPEEF LLKRRRLLGG QQLQSDDGRY VSSSSLFPPW GGGAICCSSS NNIVVVKEED KKKEKRPPPY VVKRRRLEGG QQLQSDDGRY VSSSSLYPPW ---------- ---------- ---------- ---------- ---------- ---------- DRRQVNN--- ---------- ---------- ---------- --VSSDDGRY FSSSSLLNNW GAAQVNN--- ---------- ---------- ---------- --VSSDDGRY YTTTTLLNNW WNNFFYYGGM MKNNN----S LEIKKEEFFD FGGEE----- SSHVVRLSSD SYYP------ WNNFFYYGGM MKNNN----E LELKKEEFFD FGGRR----- AAHVVRLSTD SYYP------ WDDFFYYGGQ QLHGG----D LTLDDDDWWE FPPDD----- AAHIIRLSTD SYYPSSVVKK WDDFFYYGGE EMNGG----N LELKKDDFFS FPPDD----- AAHIIRLSTD SYYPSSVV-- WEEFFYYDDM MMNGG----N LTLKKDDWWD FPPAA----- SSHIIRLSTD SYYPSSVV-- VPPFFYYGGM MKDGG----N IEFPPKKFFE WPPKK----- PPHVVRLSSD SYYP------ WEEFFYYGGM MKDNN----D MQFPPNNFFD FGGEE----- VVHIIRLSSD SFFP------ WEEFFYYGGI IKEDD----G LSLPPGGFFE VGGDD----- PPHIIRLSSD SYYPSS---- WKKFFYYDDG GVLVVVDDDN LKLPPNNLLD FGGKKPGPPP AAHLLRYSSD I--------- WKKFFYYNNG GVLIIVDDDN LKLPPNNLLD FGGKKPGPPP AAHLLRYSSD I--------- WKKFFYYDDG GVLIIVDDDK LKLPPNNLLD FGGKKPGPPP AAHLLRYSSD I--------- WKKFFYYDDG GVLIIVDDDK LTLPPNNLLD FGGKKPGPPP AAHLLRYSSD I--------- WKKFFYYDDG GVLVVVDDDK LKLPPNNLLD FGGKKPGPPP AAHLLRYSSD I--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WKKFFYYDDG GVLVVVDDDK LKLPPNNLLD FGGKKPGPPP AAHLLRYSSD I--------- WKKFFYYDDG GVLIIVDDDK LKLPPNNLLD FGGKKPGPPP AAHIIRYTSD I--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WKKFFYYDDG GVLIIVDDDK LKLPPNNLLD FGGKKPGPPP AAHLLRYSSD I--------- WKKFFYYDDG GVLIIVDDDK LKLPPNNLLD FGGKKPGPPP AAHIIRYTSD I--------- WKKFFYYGGG GHLIIVDDDK LKIPPNNFFD FGGAAPGPPP AAHMMRYTSD I--------- WKKFFYYKKG GHLIIVDDDN LKIPPNNFFD FGGAAPGPPP AAHMMRYTSD I--------- WRRFFYYEEG GHIIIVDDDK LSIPPNNFFD FGGDDPGPPP AAHMMRYTSD I--------- WVVFFYYEEG GHIIIGDDDK LTIPPDDFFD FGGDDPGPPP AAHMMRYTSD I--------- WEEFFYYDDG GHLIIVDDDK LSIPPNNFFD FGGAAPGPPP AAHMMRYTSD I--------- WDDFFYYEEG GTVVVIDDDS MEIRRDDLLD FGGKKEGPPP AAHMMRYTSD I--------- WDDFFYYEEG GTLIIVDDDT MVIKKNNLLD FGGKKPGPPP AAHMMRYTSD I--------- WKKFFYYNNG GVLIIVDDDK LTVKKNNLLD FGGKKPGPPP AAHIIRFTSD I--------- WKKFFYYEEG GTVLLIDDDN MKLEENNLLD FGGGGPGPPP PPHMMR---- ---------- WKKFFYYKKG GHVIIVDDDN ISLEEDDLLD FAANNPGPPP PPHMMRYTSD IAANDDAA-- ---------- ---------- ---------- ---------- ---------- ---------- W--------G GDAYYKAAAW KELEEDDAAD FYYEEGG--- AAHMMRFYSS ---------- W--------G GDEFFKLLLW KELEEQQAAD FYYAAKG--- PPHMMRFYAG PDDGNNRRLL ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QQRVVEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158KAKPPPSAPP RAVVVVPPTG GLLTTAAARD DQQLPPTAQQ LLLTPGIIIA AEAAWTTFSI gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -GRSAPPTLL gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIIQSPRRSS KGGRSSVVPG LLVESSSAVA AQPPSSQAAV VQQQWAWWLP PKKKHGGAAV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------E EAAAEGGFFT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------GGLK KEEEPGGTTA ---------- ---------- ---------- ---------- ----LLNNSG GLLLGFFQQT ---------- ---------- ---------- ---------- ---------- ---------- LLLNPPHHPP LAAPPPHHPR VVPLRLLVRP PRNNVVPPRL LPPPCPHHAH HLLLVLLHHI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MR REEEFGG--- ---------- ---------- ---------- ---------- --------MR RIIIVSSPPS ---------- --------MM AVDPTYPPPP PMKKPPDAYY VVCLYYTGTN AAAFFVVDVN ---------- ---------- -ADPTYPPPP PDRRPPDAYY VVALYYVGTN PPPFFVVDVD ---------- ---------- -MDPTHAAAP PLQQAAEAYY TTLLSSPDF- PPPAAVIDVK ---------- ---------- -MDPTHAAAP PLEEAANAYY TTLLSSPDF- PPPAAVIDVK ---------- ---------- -MDPTYPPPA ALEEVVKAFF TTMLSSPDA- PPPGGVVDVD ---------- ---------- -ADPSYPPPP PLKKPPTAYY VVMFDDPER- PPPAAVVDVD ---------- ---------- -VDPTYPPPP PMKKAAKAYY VVRLNNPMA- PPPAAVVDVD ---------- ---------- -ADPTYPPPP PMQQRRRGYY VVLLDDPGR- PPPAAVLDLD ---------- -------ATT KTGPGPTTTL LA--RREVYY LLCIYYRNTE PPPYYTVDVD ---------- ---------- ---------- ----RREVYY LLCIYYRNTE PPPYYTVDVD VVIIAPARRR RPPP--ASTT QGGPGPSSSL LA--RREVYY LLCIYYGNTE PPPYYTVDID ---------- ---------- ---------- ----RREIYY LLCIYYRNTE PPPYYTVDVD ---------- -------ATT KGGPGSTTTL LA--RREVYY LLCIYYRNTE PPPYYTVDVD TTQQSVAQQQ QPPPAASATT KGGPGSTTTL LA--RREVYY LLCIYYRNTE PPPYYTVDVD ---------- -------ATT KGGPGSTTTL LA-------- ---------E PPPYYTVDVD ---------- -------ATT KGGPGSTTTL LA--RREVYY LLCIYYRNTE PPPYYTVDVD AAPPWFLSSS SWWWEEDATT KGGPGPTTTQ QA--RREVYY LLCIYYRNTE PPPYYTVDVD TTTTELHTTT TLLLFFTPTT KGGPGSTTTL LA--RREVYY LLCIYYRNTE PPPYYTVDVD ---------- -------ATT KGGPGSTTTL LA--RREVYY LLCIYYRNTE PPPYYTVDVD IIEEGAAAAA AAAAAAAGKK TCGPGATTTL LAKKRRKVYY VVCVYYNGTN LLLYYTVDLD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MAA KGGPGKSSSL LA--RREVYY LLCIYYRSTN PPPYYTVDVD --AATVLDDD DVVVEEKS-- VGGPGASSSI IS--RRSIYY VVAVYYAGTE PPPYYTVDVD --GGTVLQQQ QVVVEEKNNN QGGPGASSSL LA--RRTIYY VVAVYYAGTE PPPYYTVDLD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MGPGATTTL LA--SSKIYY VVAVYYTGTD PPPYYTVDVD ---------- -AAAAAAGAA ACGPGATTTL LAKKRRKLYY VVCVYYNGTN PPPYYTVDVD ---------- -MMMPPNGLL KHGPGASSSA AA--RRELFF VVAP----ND PPPAATVDVN ---------- -MMM---PLL KHGPGASSSA AA--RRELFF VVAP----HD PPPAATVNVN ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM SSGPGATTTL LANNVVKLYY VVCVQQPNLE GGGYYTVDVD ---------- ---------- ---------- --SSRRKLYY TTTVQQPNLP GGGYYTVDVD ---------- ---------- --MPGITTT- -ISSDDFYFF SSWLHHGDIY IIIDDNPRMV ---------- -AAA--AAMM GPADECQQQP PMIIQQEVYY VVTLGGVEGD QQQKKTIDLR SSHHFALRRR RSSSLLAALL APADECAAAP PMIIQQDVYY VVTLGGAEGD QQQKKTVDAN PKKEYKIVEL LPINEELLHG GWWCCSLC-- -NG-KKKPPI IIERRRVPPP GGLSSRIYID PKKPYKVIDL LPIGEELLHG GWWCCSYC-- -NA-KKKPPL LLERRRVPPP AALSSRIYID PGGSYKIVTM MPTGEEFFHG GWWCCSLS-- -LTGHHHAAL LLERRRIPPP GGLSSRIYVD PGGPYQIVTM MPKGEEFFHG GWWCCSLS-- -LAGHHHAAI IIERRRIPPP GGLSSRIYID PTTEFQIVIM MPKGEEFFHG GWWCCSLS-- -LTGHHHAAL LLERRRIPPP GGISSRIYID PAAPYSIVAM MPAGEELLHG GWWCCSLC-- -NAPHHHPPM MMERRRVPPP GGLSSRIYID SQQSFQVVDM MPTGEELLHG GWWCCSLC-- -NAPHHHPPV VVERRRVPPP DDISSHITID PDDGYQIVEM MPAAEELLHG GWWCCSLC-- -YAPHHHPPV VVERRRVPPP GGISSRIHID PKKPYQVIPM MPLKEELLHG GWWCCS---- --FGDDDSSK KKSRNNLPPP GGLSSRIYVD PKKPYQVIPM MPLKEELLHG GWWCCS---- --FGDDDSSK KKSRDDLPPP SSISSRIYVD PKKPYQVIPM MPLREELLHG GWWCCS---- --FGDDDSSK KKSRTTLPPP CCLSSRIYVD PKKPYQVIPM MPLKEELLHG GWWCCS---- --YGDDDIIK KKARTTLPPP AALSSRIYVD PKKPYQVIPM MPLKEELLHG GWWCCS---- --FGDDDSSK KKSRTTLPPP SSLSSRIYVD PKKPYQVI-- ---------- ---------- ---------- ---------- ---------- PKKPYQVIPM MPLKEELLHG GWWCCS---- --FGDDDSSK KKSRTTLPPP SSLSSRIYVD PKKPYQVIPM MPLKEELLHG GWWCCS---- --FGDDDSSK KKSRTTLPPP SSLSSRIYVD PKKPYQVIPM MPLKEELLHG GWWCCS---- --FGDDDSSK KKSRNNLPPP SSFSSRIYVD PKKPYQVIPM MPLKEELLHG GWWCCS---- --FGDDDSSK KKSRTTLPPP SSL------- PKKPYQVIPM MPLKEELLHG GWWCCS---- --FGDDDSSK KKSRTTLPPP SSLSSRIYVD PSSPYQVIPV VIIGKKLLHG GWWCCS---- --HGDDDPPA AAKRRRLPPP SSLSSRVYVD ---------M MPTNEELLHG GWWCCS---- --YGDDDAAK KKVRNNLPPP CCLSSRIYVD PKKPYQVIPM MPVNEELLHG GWWCCS---- --YGDDDSSK KKVRNNLPPP CCLSSRIYVD PSSPYKVIPV VPVGEELLHG GWWCCS---- --HGDDDPPA AAERRRAPPP SSLSSRIYVD PNNPYKVIPV VPVGEELLHG GWWCCS---- --HGDDDPPA AAQRRRVPPP GGISSRVYVD ---------M MPVGEELLHG GWWCCS---- --HGDDDAAA AADRRRLPPP SSLSSRIYAD PSSPYSVIPM MPVGEELLHG GWWCCS---- --HGDDDAAV VVDRRRLPPP SSLSSRIYAD PNNPYQVIPV VTVGEELLHG GWWCCS---- --HGDDDPPA AASRRRLPPP SSLSSRVYVD PEEDFQVIDV VPIGEEVVHG GWWCCS---- --HDKKKPPE EEKRSSVPPP CCLSSRIYIN PEEEFQIIDV VPIGEEVVHG GWWCCS---- --HDKKKPPE EEKRSSVPPP CCLSSRIYVN ---------- ---------- ---------- ---------- ------PRRR KKLSSVEGKF PAAPYQVIYT TNKHEELLHG GWWCCSHFVV V-GGKKKEEP PPTRDDLPPP CCLSSRIFVD PEEPYQIVFT TNKGEELLHG GWWCCSYYVV VESSKKKTTP PPKRDDLPPP SSLSSFIYID GQQFGSVLPV VKLEKKEEDQ QPPRRI---- ---GKKKRRQ QQGGPPQLLL SSLGGRLYVT PGGARQVISV VG-REEAAHG GFF------- ---------- --DRRRTGGG GGLTTRIFID PKKPYKVVSV VG-REEAAHD DFF------- ---------- --DRRRAGGG GGLTTKIFVD TKKKPPRREK KIKVVIIIEE PEEEKVVSSG RLTTVVHHHH PPIIYILGGN EEGPGGGGIY TKKKKKRRRA AVKIIVVVEE PEEEGRRTTG KYTTVVHHHH PPIIYILGGG EEGPGGGGID TKKKPPTTQR RIKIIIIIEE PDDDAKKTTG RPTTVVHHHH PPIIYVLGGG DDGAPPGGIE TKKKPPTTKK KIKIIIIIEE PEEEKKKTTG RPTTIIHHHH PPIIYVLGGG NNGPPPGGVE VKKKPPLLKK KIKIIIIIEE PEEEAKKTTG RPTTIIHHHH PPIIYVLGGG DDGPPPGGIE TKKKPPLLKF FLKVVIIIEE PEEEERRTTG RPTTVVHHHH PPIIYVLGGN KKGPGGGGIQ TKKKPPTTQK KVKVVIIIDD PNNNERRTTG RPTTVVHHHH PPIIYILGGS EEGPGGGGID TKKKPPRRER RIKVVIIIEE PEEERRRTTG RPTTIIHHHH PPVVYVLGGS DDGPGGGGVE VGGGPPRRAK KLKVVIIIEE ASSSAKKCCN NTTTSSHHHH AAEEVMTLLG NNGKGGSSFE VGGGPPRRAK KLKVVIIIEE PNNNAKKCCN NLTTSSHHHH AAEEVMSLLG NNGKGGGGFE VGGGPPRRAK KLKVVIIIEE AEEEAKKCCG YVTTSSHHHH AAEEVMTLLG NNGKGGGGFE VGGGPPRRAK KLKVVIIIEE PKKKTKKCCN FFTTSSHHHH PPEEVMTLLG NNGKGGGGFK VGGGPPRRAK KLKVVIIIEE PEEEAKKCCE FLTTSSHHHH AAEEVMSLLG NNGKGGGGFE ---------- ---------- PKKKAKKCCE FLTTSSHHHH AAEEVMSLLG NNGKGGGGFE VGGGPPRRAK KLKVVIIIEE PKKKAKKCCE FLTTSSHHHH AAEEVMSLLG NNGKGGGGFE VGGGPPRRAK KLKVVIIIEE PKKKAKKCCE FLTTSSHHHH AAEEVMSLLG NNGKGGGGFE VGGGPPRRAK KLKVVIIIEE AKKKEKKCCG TPTTSSHHHH PPEEVMTLLG NNGKGGGGFE ---------- ---------- ---------- ---------- ---------- ---------- VGGGPPRRAK KLKVVIIIEE PKKKAKKCCE FLTTSSHHHH AAEEVMSLLG NNGKDDGGS- TAAAPPRRTS SLKVVVVVEE SEEEENNIIG FPTTSSHHHH AADDIMCLLG NNAAGGNNGS VGGGPPRRAR RIKTTVVVEE PYYYWKKCCG NLTTSSHHHH GGEEIMSIIG NNGKGGGGFE VGGGPPRRAR RIKTTVVVEE PYYYWKKCCG NPTTSSHHHH GGEEIMSLLG NNGKGGGGFE TKKKPPRRSS SLKVVVVVDD PAAAQKKTTG YPTTSSHHHH AAEELMCLLG NNAEGGNNGS TKKKPPRRAS SLKVVVVVEE PEEETKKTTG YPTTSSHHHH AAEEIMCIIG NNAEGGNNGS TKKKPPRRAS SLKYYVVVDD PKKKEKKTTG YPTTAAHHHH AAEEILCLLG NNAKGGNNGS TKKKPPRRAS SLKYYVVVDD PKKKDKKTTG FPTTAAHHHH TTEEILCLLG NNAKGGNNGS TLLLPPRRAA ALKVVVVVEE AEEEEKKTTG FPTTSSHHHH AAEEIMCLLG NNAAGGNNGS VEEE--RRKY YLHTTIIIEE PSSSSLLNN- FPTTSSHHHH AANNIMTLLG TTPSGGNNFK VEEE--RREY YLHTTIIIEE PSSSALLNN- FPTTSSHHHH AANNIMTLLG SSPSGGNNFK VGGG------ ---------- ---------- ---------- ---------- ---------- TGGGPPRRAK KLKVVIIIEE G---KGGAAD APTTTTHHHH PPNNIMIMMG NNAKGG--DK VVVVPPRRKE EIKTTIIIDD G---KSSHHN APTTTTHHHH AANNIMVMMG YYAKGG--DS SLLLAAWWDQ QFP------- ----KFFLLV ISTTAADDDD PPAALKGVVN VVPVLLNNGH VHHHPPSSNK KLKTTIIIDD T---DSSGGG GPTTFFFFFF PPMMMILSSN GGGRTTAALD VHHHPPAARV VLKTTIIITT D---KSSGGG GPTTLLYYYY PPMMLILSSN GGGRTTAALA SSSEGKKKWE IDDDQQQQQQ -------LLY FFWWLLLLL- PNNELLVVSE EEWWVVN--T TTTEGRRRWE VYPPQQQQQQ -------FFY FFWWLLLLL- PSSGMMIITE EEWWVVR--C TTTDGRRRWE IDPPQQQQQQ -------KKY FFWWLLLLL- PRRDMMVVSE EEWWLLP--Q TTTEGRRRWE IDPPQQQQQQ -------LLY FFWWLLLLL- PRRDMMVVTE EEWWLLP--Q TTTEGRRRYE MDEEQQQQQQ -------KKY FFWWLLLLL- PRRDMMVVSE EEWWLLP--Q SSSEGRRRWE VEPPQQQQQQ -------FFY GGWWLLLLL- GYYDLLVVTE EEWWTTD--M NNNEGRRRWE IDDDQQQQQQ -------LLY FFWWLLLLL- GYYDLLLLTE EEWWTTR--M SSSDGRRRWE VEPPQQQQQQ -------LLY FFWWLLLLL- GYYDMMVVTE EEWWTTN--M TTTEGTTTWE KPAASSSSSS -------MMY FFWYPPPPP- RHHNMMVVSE EEWWAAN--V TTTEGTTTWE KPEEAAAAAA -------MMY FFWYPPPPP- RHHNMMVVSE EEWWAAN--V TTTEGTTTWE QPAAAAAAAA -------MMY FFWYPPPPP- RHHNMMIISE EEWWAAN--V TTTEGTTTWE QPAAAAAAAA -------LLY FFWYPPPPP- RHHNMMIISE EEWWAAN--V TTTEGTTTWE RPAAAAAAAA -------SSY FFWYPPPPP- RHHNMMIISE EEWWAAN--V TTTEGTTTWE RPAAAAAAAA -------LLY FFWYPPPPP- RHHNMMIISE EEWWAAN--V TTTEGTTTWE RPAAAAAAAA -------LLY FFWYPPPPP- RHHNMMIISE EEWWAAN--V TTTEGTTTWE RPAAAAAAAA -------LLY FFWYPPPPP- RHHNMMIISE EEWWAAN--V TTTEGTTTWE RPSSAAAAAA -------MMY FFWYPPPPP- RHHNMMIISE EEWWAAN--V ---------- ---------- ---------- ---------- ---------- ---------- RRREG----- ---------- ---------- ---------- ---------I IISSHHN--L EEENGRRRGS NRPPIIIIII -------KKR HHLYNNNNNY AWWGFFWWSI IIQQCCL--F TTTEGNNNWE AEAAAAAAAA -------FFY FFWYPPPPP- RHHNMMIISE EEWWAAK--A TTTEGNNNWE VESSAAAAAA -------FFY FFWYPPPPP- RHHNMMIISE EEWWAAK--A DDDNGRRRWE KPSSPPPPPP -------FFY FFWYPPPPP- RHHNMMIISS SSWWAAT--A EEENGRRRWE KPSSPPPPPP -------FFY FFWYPPPPP- RHHNMMIISS SSWWAAK--A DDDNNRRRWE KPSSPPPPPP -------FFY FFWYPPPPP- RHHKMMIISS SSWWAAK--A DDDNNRRRWE KPSSPPPPPP -------YYY FFWYPPPPP- RHHKMMIISS SSWWAAK--A EEENGRRRWE KPSSPPPPPP -------FFY YYWYPPPPP- RHHKMMIISS SSWWAAA--A TTTEGTTTWP ADTTVVVVVV -------FFY FFWYPPPPP- RRRNMMIISE EEWWSSN--H TTTEGTTTWP ADVVVVVVVV -------FFY FFWYPPPPP- RRRNMMIISE EEWWSSN--H ---------- ---------- ---------- ---------- --------SL LLRRGGV--T NNNEGTTTWS RGKKAAAAAA -------CCY YYWYPPPPP- HFFNMMVVAE EEWWAAK--L DDDNGTTTWT KGKKAAAAAA -------CCY FFWYPPPPP- YFFDMMVVSE EEWWAAN--K EEEGAKKKGE ASEEEEEEEE -------LLL NNHNGGGGG- -RRESSEESR RRPPEEI--M GGGYTYYYWM PTDDMMMMMM AAVVGGDYYY IIRAIIIII- RKKNMMLLTS SSFFGGSNYM GGGYTHHHWI PTDDLLLLLL AKTTGGDYYY VVRAPPPPP- RKKNLLVVTS SSFFGGNNYM EDDGKKLEEL LL---GNRRR FWWDLKRRRI ILTTTGGEEN RMAA------ -LLLRPPPDD EEEGSSLEEL LLGGGGNKKK VWWDLKRRHL LIDDDGGEEH RMVV------ -VVVRPPPDD ENNGVVPEEL LLNNNGHRRR FWWDLARRNV VIDDDGGQQH QMAA------ -VVVRPPPDD ENNGVVPEEL LLNNNGHRRR FWWDLARRNV VIDDDGGNNH QMAA------ -VVVRPPPDD ENNGVVPEEL LLNNNGHKKK FWWKLDRRNV VIDDDGGNNH QMAA------ -IIIRPPPDD EDDGVVPDDL LLAAAGRRRR FWWDLRRRHL LIDDDGGEEH QLVV------ -LLLRPPPDD ESSGLLGDDL LLGGGGHRRR VWWDLRRRHL LLDDDGGEEY QMAA------ -LLLRPPPDD EGGGDDPQQL LLKKKGRRRR IWWDLRRRHL LLDDDGGEEH QMVV------ -LLLRPPPDD KDDGPPAHHE EEGGGGSRRR VWWDWRHHII ILQQQTT--D GLII-----L LIIIRFFFDD KDDGPPAHHE EEGGGGSHHH VWWDWRHHII ILQQQKK--D GLII-----L LIIIRFFFDD RDDGPPADDE EEGGGGSHHH VWWDWRHHII ILTTTQQ--D GLII-----L LIIIRFFFNN RDDGPPADDK KKGGGGSHHH VWWDWRRRIV VLPPPQQ--D GLII-----L LIIIRFFFNN RDDGPPADDE EEGGGGSHHH VWWDWHHHIV VLSSSKK--D GLII-----L LIIIRFFFNN RDDGPPADDE EEGGGGSHHH VWWDWRHHIV VLSSSKK--D GLII-----L LIIIRFFFNN RDDGPPADDE EEGGGGSHHH VWWDWRHHIV VLSSSKK--D GLII-----L LIIIRFFFNN RDDGPPADDE EEGGGGSHHH VWWDWRHHIV VLSSSKK--D GLII-----L LIIIRFFFNN QNNGPPADDE EEGGGGKHHH VWWDWRHHIV VLLLLPP--D GHII-----L LIIIRFFFDD ---------- ---------- ---------- ---------- ---------- ---------- LTTGDDYPPS SSSSSAGIII ---------- ---------- ---------- ---------- TTTGLLMCCT TTSSSHVIII LDDNYMRRID DLPPPQQ--D QAGGNNNNPL LLLLRSSSWW ALLGMMEEEQ QQGGGGHSSS VWWDWEHHRI IIDDDGG--D GLII-----L LIIIRFFFDD ALLGMMEDDQ QQGGGGHSSS VWWDWEHHLV VIDDDGG--D GLII-----L LIIIRFFFNN TKKGLLQHHA AAGGGGRHHH CIIQLRGGLR RLDDDGG--T GLLL-----L LIIIRFFFDD LQQGLLQHHA AAGGGGRHHH VYYSWGGGIK KLDDDGG--K GLLL-----L LIIIRFFFDD SKKGLLQHHA AAGGGGSHHH VYYSWGGGMK KIDDDGG--T GLLL-----L LIIIRFFFDD SKKGLLQHHA AAGGGGSHHH VYYSWGGGIK KIDDDGG--T GLLL-----L LIIIRFFFDD RTTGLLQHHQ QQGGGGRHHH VYYDWGGGLK KLDDDGG--T GLLL-----L LVVVRFFFDD KKKGPPAHHG GGGGGGNSSS IFFEWSKKYL LIDDDPPPPL GALL-----L LVVVRFFFEE KKKGPPAHHP PPGGGGNSSS IFFEWTKKHL LIDDDPPPPR GALL-----L LVVVRFFFEE CRRDLLKCCP PPPPPIKCCC VYY------- ---------- ---------- ---------- RRRGPPTDDD DDTTTGCRRR FYYRWERRLF FIDDDGG--D GLTT-----L LIIIRFFFNN RRRGNNVDDE EESSSGCRRR FYYKWTQQLY YIDDDGG--D GITT-----L LIIIRFFFNN FEESSSFLLK KKPPPPQHHH EVVL------ ---------- ---------- ---------- DFFGLLQDDE EEKKKGNTTT QWWDLTRRPK KFNNNPPAAP ---------L LIIIRFFFGG DFFGLLADDE EEKKKGNTTT TWWDLTKKPK KFDDDPPAAP ---------L LIIIRCCCGG TTLGIINMVK DDLLSSSSSI LLWWWFYY-- -EDKKWNVEI IPPAGNNLPE EILKKAAVVP TTLGVVNVVK DDLLSSSSSI LLWWWFYY-- -EDKKWQVDI IEEAGPPLPP PVLKKMMVVP VVEGVVGVVT NNLLEGGGSI TTWWWWRR-- -EGKKFHTTI IPPAAEELPP PLLQQAAVVP VVEGVVGVVT NNLLEAAASI TTWWWWRR-- -EGKKFHTTI IPPPKKKLPP PLLQQAAVVP SSDGCCGVVT NNLLQGGGAI TTWWWWQQKK KDDTTFETTI IDDPADDLPD DLLKKAACCP TTAGVVNCVK DDLLSSSSSI TTWWWYRR-- -DKKKWAVEI IPPAPQQLPP PVLKKAAVVP TTAGMMNCVK DDLLSAAASI LLWWWYRR-- -DNSSWHVDI IPPAEQQLPP PILKKAAVVP AATGVVGVVE DDLLSAAASV LLWWWHRR-- -QNSSWGVEI IPPAPQQLPP PLLKKAAVVP SSTGVVGCAN IIQQRFFFYK EEEEEG---- --------WS SVVEVSSKKV VKGWWEEMMP DDTGVVGCAN IIQQRFFFYK EEGGGG---- --------WS SVVEVSSKKV VKGWWEEMMP DDAGVVGCAT IIQQRFFFYK QQGGGG---- --------WS SVVEVPPKKV VKGWWEEMMP DDAGVVGCAT IIQQRFFFFK EEDDDG---- --------WS SAAQVPPKKV VKGWWEEMMP DDAGVVGCAT IIQQRFFFYK EEGGGG---- --------WS SVVEVPPKKV VKGWWEEMMP DDAGVVGCAT IIQQRFFFYK EEGGGG---- --------WS SVVEVPPKKV VKGWWEEMMP DDAGVVGCAT IIQQRFFFYK EEGGGG---- --------WS SVVEVPPKKV VKGWWEEMMP DDAGVVGCAT IIQQRFFFYK EEGGGG---- --------WS SVVEVPPKKV VKGWWEEMMP AASGVVGCAT IIQQRFFFYK EEGGGG---- --------WS SVVEVPPKKV VKGWWEEMMP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NNNDDDVVES GGRRGGGGSD DDAAAY---- --------VV VLLKLYYAVV VAKFFSSLLS DDAGVVGCAT VVFFRFFFYK KKDDDG---- --------WA AAAEVSSKKV VEGWWEEMMP DDDGVVGCAS IIFFRFFFYK KKDDDG---- --------WA AAAEVSSKKV VEGWWEEMMP AADGVVGSAN MMIIRFFFFK QQDDDG---- --------WS SHHEVPPLKV VQNWWEEMMP AADGVVGSAN MMIIRFFFFK QQDDDG---- --------WN NHHEVPPLKV VQNWWEEMMP SSDGVVGSAN MMIIRFFFFK SSDDDD---- --------WS SYYEVPPLKV VENWWEEMMP SSDGVVGSAN MMIIRFFFFK SSDDDE---- --------WS SHHEVPPLKV VENWWEEMMP SSDGVVGCAN MMVVRFFFFK AADDDG---- --------WS SHHEIPPLKV VRNWWEEMMP TTEAVVGCAG IIFFRIIIHP EEEEENSS-- --------HA AAATISSKKV VSGWWEEMMP TTEAVVGCAA IIFFRIIIHP EEKKKNPP-- --------QT TAASISSKKV VENWWDDMMP ---------- ---------- ---------- ---------- ---------- ---------- RRNGVVGCAX XXXXXXXXX- ---------- ---------- --------QG GENGGMMMMG KKAGVVGCAK VVFFHFFFKK SSDDDSDD-- -------FAK KKKVGLLVDT TGSGGDDMMG ---------- ---------- ---------- ---------- ---------- ---------- NNNASSTTAQ LLWWLIIIYE DDAAAG---- ---------- ----WAAKAV VADIIAADDI AANCTTSTAQ LLWWLIIIYE GGEEEG---- ---------- ----WAAKAV VADIIAAKKV PPVVVDIIDD ISSKFLYLLL LGGGGGGRRQ QYDISSSNPP FKKPVVVKKL FHP------- PPVVVDIIDD ISSRFLYVVL LGGGGGGRRQ QYDITTTNPP HQQPRRVKKI YHP------- PPVVVDIIDD LSSRFLYVVC CGGGGGGRRQ QYDVSSSDPP HNNPVVVRRI ARP------- PPVVVDIIDD LSSRFLYVVC CGGGGGGRRQ QYDVSSSDPP RKKPKKVHHI ARP------- PPVVVDIIDD LSSKYLYVVC CGGGGGGHHQ QYDVSSSDPP MNNPVVVEEI VKP------- PPVVVDIIDD LSSRFLYVVC CGGGGGGLLQ QYDVSSSDPP FEEPKKVRRI VSPG------ PPVVVDIINN LSSRFLYVVC CGGGGGGHHQ QYDVSSSDPP FNNPRRVQQI VRP------- PPVVVDIINN LSSRFLYVVC CGGGGGGRRQ QYDVSSSDPP FNNPRRVRRL VRP------- GGIIIDIILL LSSRFLYFFN NLLLGGGRRQ QYDISSSNPP QKKPRRIFFL IVVQVL--QQ GGIIIDIILL LSSRFLYFFN NLLLGGGRRQ QYDISSSNPP KKKPRRIFFL IVVQVL--QQ GGIIIDIILL LSSRFLYFFN NLLLGGGRRQ QYDISSSDPP QRRPRRLFFL IVVQVL--QQ GGIIIDIILL LSSHFLYFFN NLLLGGGRRQ QYDVSSSDPP QRRPRRLFFL IVVQVL--QQ GGIIIDIILL LSSRFLYFFN NLLLGGGRRQ QYDISSSDPP QRRPRRLFFL IVVQVL--QQ GGIIIDIILL LSSRFLYFFN NLLLGGGRRQ QYDISSSDPP QRRPRR---- ---------- GGIII----- ---------- ---------- ---------- ---------- ---------- GGIIIDIILL LSSRFLYFFN NLLLGGGRRQ QYDISSSDPP QRRPRRLFFL IVVQVL--EE GGIIIDIILL LSSRFLYFFN NLLLGGGRRQ QYDISSSDPP KRRPRRIFFL IVVQVL--QQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NNFFFPAAWW IFFLLIIFFS S--------- ---------- ---------- ---------- GGIIIDIILL ISSRFLYFFN NLLLGGGRRQ QYDITTTDPP RNNPKKIFFL ILVTVL--KK GGIIIDIILL ISSRFLYFFN NLLLGGGRRQ QYDITTTDTT RNNPKKIFFL IQVTVL--KK GGIIIDFFLL ISSRFLYFFN NLLLGGGRRQ QYNIEEEDLL KNNPVVLWWV IQVAAI--DD GGIIIDFFLL ISSRFLYFFN NLLLGGGRRQ QYNIEEEDVV KNNPKKVWWA IQVVAV--DD GGIIIDFFLL ISSRFLYFFN NLLLGGGRRQ QYNIEEEDPP KNNPVVIWWV LQVKAV--DD GGIIIDFFLL ISSRFIYFFN NLLLGGGRRQ QYNIEEEDPP KNNPVVIWWV LQVKAV--DD GGIIIDFFVV ISSRYLYLLN NLLLGGGRRQ QYNIEEEDPP AKKPVVVWWA LQVVYV--DD AAIIIDIILL ISSRFLYVVC CLLLGGGRRQ QYDISSSDPP LKKVKKVYYI VHVKVL--EE AAIIIDIILL ISSRFLYVVC CLLLGGGRRQ QYDISSSDPP KNNPKKVFFI IHVKVL--DD ---------- ---------- ---------- ---------- ---------- ---------- GGMMMDIILL ISSRYLYFFN NRRRGGGRRQ QYDISSSDRR ANNPRRVFFL IQRRVL--PP GGIIIDIIII ISSRFLYVVC CRRRGGGRRQ QYDITTTDPP ENNPKKLFFL ICNVIVEEKK ---------- ---------- ---------- ---------- ---------- ---------- PPPPPDIISS IAAQTLWIIS SMMMGGGRRL LFDISSSDPP HKKPFFKVVI VN-------- PPPPPDIISS ISSSRLWVVT TMMMGGGRRL LFDISSSDPP HHHPRRKTTI VN-------- ---------- AAAGGHKLAP QQQLLEEIRD DRVYYTNNNN NLSSWWWWDD NNQFFYYPGK ---------- SSSGGAEAAP QQQIISSVRD DRVYYTNNNN NLSSWWWWNN NNQFFYYPGR ---------- NNNGGRTFGP QQQVVEEIRD DRVYYTNNNN NLSSWWWWDD DDQFFYYPGP ---------- NNNGGKAFGP QQQVVEEIRD DRVYYTNNNN NLSSWWWWDD DDQFFYYPGP ---------- NNNGGKTFGP QQQVVEEIRD DRVYYTNNNN NLSSWWWWDD EEQFFYYPDG ---------A KKKNNGALGP QQQVVEEIRD DRVYYTNNNN NLGGVVVVDD PPQFFYYPGD ---------A TTTSSAELGP QQQVVEEIRD DRVYYTNNNN NLRRWWWWDD EEQFFYYPGK ---------- AAASSGPLGP QQQVVEEVRD DRVYYSNNNN NLAAWWWWDD EEQFFYYPGR LTTCQPEPLV KKKGGKRIGP QQQIIQQLLD DRLYYTTTTT TLSSWWWWDD KKQFFYY-DI LTTCQPEPLV KKKGGKRVGP QQQIIQQLLD DRLYYTTTTT TLSSWWWWDD KKQFFYY-NI LKKSQPEPLV KKKGGKKVGP QQQIIQQLLD DRLYYTTTTT TLSSWWWWDD KKQFFYY-DI LDDSQPEPLV KKKGGKQVGP QQQIIQQLLD DRLYYTTTTT TLSSWWWWDD KKQFFYY-DI LKKSQPEPLV KKKGGKRVGP QQQIIQQLLD DRLYYTTTTT TLSSWWWWDD KKQFFYY-DI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LKKSQPEPLV KKKGGKRVGP QQQIIQQLLD DRLYYTTTTT TLSSWWWWDD KKQFFYY-DI LKKSQPEPLV KKKGGKRVGP QQQIIQQLLD DRIYYTTTTT TLSSWWWWDD KKQFFYY-DI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LEECQPDPVV KKKGGKKVGP QQQIIQQLLD DRLYYTNNNN NLSSWWWWDD KKQFFYY-DI LEECQPDPVV KKKGGKIIGP QQQIIQQLLD DRIYYTSSSS SLSSWWWWDD KKQFFYY-DL KTTWQSDVPI QQQGGQKLGP QQQIIQQLLD DRLYYTNNNN NLSSWWWWDD KKQFFYY-GV ETTWQSDVPI QQQGGKKLGP QQQIIQQLLD DRLYYTNNNN NLSSWWWWDD KKQFFYY-KV NSSFQFDVPI KKKGGKSLGP QQQIIQQLLD DRLYYTNNNN NLSSWWWWDD RRQFFYY-EM NTTFQFEVPI KKKGGKSLGP QQQIIQQLLD DRLYYTNNNN NLSSWWWWVV VVSFFYY-EM KEEEQYSVPV KKKGGHRLGP QQQIIQQLLD DRIYYTNNNN NLSSWWWWDD EEQFFYYGDV ----PIEALV KKKGGRKIGP QQQLLQQLLD DRLYYTTTTT TLKKWWWWDD DDQFFYY-EV D---EIPALV KKKGGRQIGP QQQLLQQLLD DRLYYSTTTT TLKKWWWWDD DDQFFYY-EV ---------- --------GP AAAIIQQLVD DRLYYTNNNN NFSSWWWWDD KKQFFYY-NV LKKEAPEPVL KKKGGRRLGP QQQLLQQLLD DRLYYSSSSS SLSSWWWWDD KKQFFYY-EV LKKERPPARV KKKGGRRLGP QQQLLQQLLD DRLYYSSSSS SLSSWWWWDD KKQFFYY-KV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---VVSSQWD DRVYYSSSSS SLAAWWWWDD ---------- ---------- ---------- ---VVSSSWD DRLYYTSSSS SLAAWWWWDD ---------- GGMVVKLNNA --PPSGGEIK EEEEEFFDDF GE-------- -SRLLSSSGG GGDASDDYYY GGMAAKVNNV --PPEGGELK EEEEEFFDDF GR-------- -ARLLWWWGG GGDASDDFYY AAQVVLAHHA --PPDGGTLD DDDDDYWEEF PDGG------ -ARLLEEEGG GGDCSDDFYY GGEVVMANNV --GGNGGELK DDDDDYFSSF PDGG------ -ARLLEEEGG GGDCSDDFYY AAMVVMANNV --EENGGTLK DDDDDFWDDF PAGG------ -SRLLEEEGG GGDCSDDFYY GGMVVKLDDA --PPNGGEFP KKKKKFFEEW PKGG------ -PRLLQQQGG GGDCSDDYYY GGMVVKVDDV --PPDGGQFP NNNNNFFDDF GE-------- -VRLLQQQGG GGDASDDYFF GGIAAKAEEA --PPGGGSLP GGGGGFFEEV GDGG------ -PRLLEEEGG GGDSSDDYYY RRGSSVMLLQ TTVVNGGKLP NNNNNFLDDF GKEELLGGPP PARYYPPPGG GGDCSDDW-- RRGSSVMLLQ TTAANGGKLP NNNNNFLDDF GKEELLGGPP PARYYPPPGG GGDCSDDW-- RRGSSVMLLQ TTVVKGGKLP NNNNNFLDDF GKEELLGGPP PARYYPPPGG GGDCSDDW-- RRGSSVMLLQ TTVVKGGTLP NNNNNFLDDF GKEELLGGPP PARYYPPPGG GGDCSDDW-- RRGSSVMLLQ TTVVKGGKLP NNNNNFLDDF GKEELLGGPP PARYYPPPGG GGDCSDDW-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRGSSVMLLQ TTVVKGGKLP NNNNNFLDDF GKEELLGGPP PARYYPPPGG GGDCSDDW-- RRGSSVMLLQ TTVVKGGKLP NNNNNFLDDF GKEELLGGPP PARYYPPPGG GGDCTDDW-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKGSSVMLLQ TTEEKGGKLP NNNNNFLDDF GKEEGGGGPP PARYYPPPGG GGDCSDDW-- KKGAAVMLLQ TTKKKGGKLP NNNNNFLDDF GKEEDDGGPP PARYYPPPGG GGDCTDDW-- EEGSSHILLQ TTEEKGGKIP NNNNNFFDDF GAEEDDGGPP PARYYPPPGG GGDCTDDW-- EEGSSHILLQ TTEENGGKIP NNNNNFFDDF GAEEDDGGPP PARYYPPPGG GGDCTDDW-- DDGSSHIIIQ TTEEKGGSIP NNNNNFFDDF GDEEEEGGPP PARYYPPPGG GGDCTDDW-- EEGSSHIIIQ TTEEKGGTIP DDDDDFFDDF GDEEDDGGPP PARYYPPPGG GGDCTDDW-- KKGSSHMLLQ TTEEKGGSIP NNNNNFFDDF GAEEEEGGPP PARYYPPPGG GGDCTDDW-- KKGAATMVVQ PPEESGKEIR DDDDDFLDDF GKIIGGGGPP PARYYPPPGG GGDCTDDW-- RRGAATMLLQ PPIITGHVIK NNNNNFLDDF GKVVGGGGPP PARYYPPPGG GGDCTDDW-- KKGSSVMLLQ TTEEKGGTVK NNNNNFLDDF GKEENNGGPP PARFFPPPCC GGDSTDDL-- AAGGGTIVVQ VVEENGGKLE NNNNNFLDDF GGEEYYGGPP PPR------- ---------- SSGGGHIVVL TTVVNGGSLE DDDDDFLDDF ANEEYYGGPP PPRYYPPPGG GGDCTDDWAA ---------- ---------- ---------- ---------- ---------- ---------- KKGKKDDAAQ YYNNWDGELE DDDDDFADDF YELLLLGG-- -ARFFGGGSS SSALYSS--- KKGKKDDEEQ YYYYWDGELE QQQQQFADDF YAEELLGG-- -PRFFGGGAA RRALYGGADD PP----- PP----- PPVKKR- PPV---- PPV---- PP----- PP----- PP----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- NNA---- ------- ------- GGRLLVQ 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMKKKKSEAA TPPCTTGLLT RLLAADDGAM QQSSSLRTQQ LSLTTGSPPP VVRRAAEEEA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ------GGGS gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TFSILLASSS PPRRREEKGG GRTRRVVVPP GVEISAAAKS QQAAVVQAAA AAAHLPKGAV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----EAGAT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MLKEGHA ---------- ---------- ---------- ---------- -------LLL LLLKSGLFDT ---------- ---------- ---------- ---------- ---------- ---------- PTLLRRTPPT PPHHHNNLAA APSPPHHHPP RPLTLVPPYV PPPRLLPPPP PPPPAHLLQI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MREG-- ---------- ---------- ---------- ---------- ---------- ----MRISGS ---------- ---------- -----AIVVP FFFKKKRRRT FFFYYPPKMM MMAPPDLAAY ---------- ---------- ------MAAK LLLKKKPPPT FFFYYPPRDD MMAPPDIAAY ---------- ---------- -------MMS MMMRRRPPPT FFFHHAAELL MMAAAEFAAY ---------- ---------- -------MMT MMMRRRPPPT FFFHHAAKLL MMAAANFAAY ---------- ---------- -------MMT LLLRRRPPPT FFFYYPPKLL MMGVVKLAAF ---------- ---------- ------MAAT WWWKKKPPPS FFFYYPPRLL AAAPPTIAAY ---------- ---------- ------MVVT WWWRRRPPPT FFFYYPPRMM VVAAAKLAAY ---------- ---------- ------MAAS WWWRRRPPPT FFFYYPPKMM MMARRRLGGY ---------- ---------- ----MKCTTK ------CCCG YYYPPTTEAA KKGRREIVVY ---------- ---------- ---------- ---------- ---------- MMGRREIVVY LLLLLIIIPP PPARGGGLPP --AAHQCGGK ------CCCG YYYPPSSEAA KKGRREIVVY ---------- ---------- ---------- ---------- ---------- KKGRREIIIY ---------- ---------- ----MKCGGN ------CCCG YYYSSTTEAA KKGRREIVVY LLLLLQQQVV VVAQPPPRPP AASSTKCGGN ------CCCG YYYSSTTEAA KKGRREIVVY ---------- ---------- ----MKCGGN ------CCCG YYYSSTTEAA KKG------- ---------- ---------- ----MKCGGN ------CCCG YYYSSTTEAA KKGRREIVVY QQQQQPPPFF FFLSGGGLWW EEDDTKCGGD ------CCCG YYYPPTTEAA KKGRREIVVY NNNNNTTTLL LLHTYYYTLL FFTTSKCGGN ------CCCG YYYSSTTEAA KKGRREIVVY ---------- ---------- ----MKCGGN ------CCCG YYYSSTTEAA KKGRREIVVY MMMMMEEEAA AAAAVVVTAA AAAANTCCCH TTTAAAKKKG YYYAATTEAA EEGRRKLVVY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----KCGGS ------CCCG YYYKKSSDAA KKGRREIVVY MMMMMAAAVV VVLDHHHVVV EEKKKVNGGC CCCKKKSSSG YYYAASSESS SSGRRSLIIY MMMMMGGGVV VVLQHHHVVV EEKKVQQGGC CCCKKKSSSG YYYAASSEAA SSGRRTLIIY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------RMML QQQVVVGGGG YYYAATTAAA SSGSSKLIIY ---------- -------MAA AAAANACCCG GGGAAATTTG YYYAATTEAA EEGRRKLLLY ---------- --------MM PPNNCKCHHG ---------G YYYAASSDAA KKGRREVLLF ---------- --------MM ----CKCHHG ---------G YYYAASSDAA KKGRREVLLF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----SESSK CCCKKKCCCG YYYAATTDAA RRGVVKLLLY ---------- ---------- ---------- ---------- ---------- RRGRRKLLLY ---------- ---------- ---------- ---------G LLLIITTDII IILDDFLYYF ---------- ----AAAAAA --AALGLPPF RRRAAAFFFE TTTCCQQYMM KKTQQEFVVY MMMMMHHHAA AALRAAAVSS LLAALAAPPA GGGVVVRRRE TTTCCAAYMM KKTQQDYVVY CCLLYGINRA AFIIAAVVVD PKSSEETYYS KIIIVHHKVV INDEEELLFN NSSAA-GG-- AALLYGVNAP PFLLAAVVVD PKSSPPTYYG KVVVIYYKLL IGDEEELLFN NSSAA-AA-- LLLLSS--RP PALLAAVIID PGSSSSTYYG KIIIVHHTVV TGDEEEFFFN NSSSS-TTGG LLLLSS--KP PALLAAVIID PGSSPPTYYG QIIIVHHTVV KGDEEEFFFN NSSAA-AAGG MMLLSS--KP PGLLAAVVVD PTSSEEKFFG QIIIVHHQLL KGDEEEFFFN NSSAA-TTGG MMFFDK--QP PAIIAAVVVD PASSPPRYYA SIIIVGGQVV AGDEEELLFN NSSCC-AAPP RRLLNNG-KP PAMMCCVVVD SQSSSSTFFG QVVVVGGVTT TGGEEELLFN NSSMM-AAPP LLLLDE--RP PALLGGVLLD PDSSGGTYYA QIIIVGGRVV AADEEELLFN NSAAA-AAPP CCIIYGTEAP PYLLAATVVD PKSSPPQYYS QVVVIHHRLL LKDEEELLSN NSSCC-FFGG CCIIYGIEAP PYLLAATVVD PKSSPPHYYS QVVVIHHRLL LKDEEELLSN NSSCC-FFGG CCIIYGIEAP PYLLAATVVD PKSSPPQYYC QVVVIHHRLL LRDEEELLSN NSSCC-FFGG CCIIYGIEAP PYLLAATVVD PKSSPPQYYC QVVVIHHRLL LKDEEELLSN NSSCC-YYGG CCIIYGTEAP PYLLAATVVD PKSSPPQYYC QVVVIHHRLL LKDEEELLSN NSSCC-FFGG CCIIYGTEAP PYLLAATVVD PKSSPPQYYC QVVVIEE--- ---------- ---------- ------TEAP PYLLAATVVD PKSSPPQYYC QVVVIHHRLL LKDEEELLSN NSSCC-FFGG CCIIYGTEAP PYLLAATVVD PKSSPPQYYC QVVVIHHRLL LKDEEELLSN NSSCC-FFGG CCIIYGTEAP PYLLAATVVD PKSSPPQYYS QVVVIHHRLL LKDEEELLSN NSSCC-FFGG CCIIYGTEAP PYLLAATVVD PKSSPPQYYC QVVVIHHRLL LKDEEELLSN NSSCC-FFGG CCIIYGTEAP PYLLAATVVD PKSSPPQYYC QVVVIHHRLL LKDEEELLSN NSSCC-FFGG CCVVYGINKL LYLLAATVVD PSSSPPTYYS QVVVIHHRLL IGDKKKLLSN NSSCC-HHGG ---------- ---------- ---------- ---------- TNDEEELLSN NSSCC-YYGG CCIIYGINKP PYLLAATVVD PKSSPPSYYS QVVVIHHRLL VNDEEELLSN NSSCC-YYGG AAVVYGIEKP PYLLAATVVD PSSSPPTYYS KVVVIHHRLL VGDEEELLTN NSSCC-HHGG AAVVYGIEKP PYLLAATVVD PNSSPPTYYS KVVVIHHRLL VGDEEELLTN NSSCC-HHGG ---------- ---------- ---------- ---------- VGDEEELLSN NSSCC-HHGG AAVVYGIDKP PYLLAATVVD PSSSPPSYYS SVVVIHHRLL VGDEEELLSN NSSCC-HHGG CCVVYGINKP PYLLGGTVVD PNSSPPTYYS QVVVIHHRLL VGDEEELLSN NSSCC-HHGG AAPP-AADGP PAIIFFTVVD PESSDDTFFC QVVVISSRVV IGDEEEVVTN NSSCC-HHDD AAPP-ARDGP PAIIFFTVVN PESSEETFFC QIIIISSRVV IGDEEEVVTN NSSCC-HHDD ---------- ---------- ---------- ---------- ---------- ---------- CCVVQDEEHG GYLLAATVVD PASSPPTYYC QVVVIHHRTT KHNEEELLSN NSSCCVGGGG TTVVQDEPHG GYLLSSTVVD PESSPPTYYC QIIIVHHRTT KGDEEELLSN NSSCCVSSSS WWLLHRQYDI IDRRKKNPPR GQVVFFLGGG SVVVLKKDGG LEDKKKEEST TILKK---GG TTLLGMGDEQ QKLLVVTIID PGSSAATRRG QVVVINNSVV -RNEEEAAGS S--------- TTLLGVGDEQ QKLLVVTVVD PKSSPPQYYG KVVVVNNTLL -RNEEEAAST T--------- KKPPEERRRF FLLGLLRSSI IYIIIITTKN NNPPRRPPII IVEEPEVVKV GYYSRLLTTT KKPPEERRRY YLLALLRSSI IYIIVVTTKD DDKKRRPPVV AIEEPEAAGR GYYTKYYTTT HHAAEERRRF FLLGLLRSSI IYVVIITTKH HHPPTTAAII HIEEPDIIAK GYYSRPPTTT HHAAEERRRY YLLGLLRSSI IYIIIITTKD DDPPTTAAII HIEEPEVVKK GYYSRPPTTT HHAAEERRRY YLLGIIRSSI IYIIVVVVKE EEPPLLAAII HIEEPEVVAK GYYSRPPTTT HHPPEERRRY YLLGLLRSSI IYIILLTTKD DDPPLLPPLL AVEEPELLER GYYSRPPTTT HHPPEERRRY YLLDIIRSSI ITIILLTTKD DDPPTTPPVV VVDDPNLLER GYYARPPTTT HHPPEERRRY YLLGIIRSSI IHIIVVTTKD DDPPRRPPII VVEEPELLRR GYYSRPPTTT DDSSSSRRNK KLLGLLMSSI IYVVVVVVGE EEPPRRPPLL HVEEASIIAK NVVSNTTTTT DDSSSSRRDK KLLSIIISSI IYVVVVVVGE EEPPRRPPLL HVEEPNIIAK NLLGNLLTTT DDSSSSRRTK KLLCLLMSSI IYVVVVVVGD DDPPRRPPLL HVEEAEIIAK GLLGYVVTTT DDIIAARRTK KLLALLISSI IYVVVVVVGE EEPPRRPPLL HVEEPKIITK NLLGFFFTTT DDSSSSRRTK KLLSLLISSI IYVVVVVVGE EEPPRRPPLL HVEEPEIIAK ELLAFLLTTT ---------- ---------- ---------- ---------- ----PKIIAK ELLAFLLTTT DDSSSSRRTK KLLSLLISSI IYVVVVVVGE EEPPRRPPLL HVEEPKIIAK ELLAFLLTTT DDSSSSRRTK KLLSLLISSI IYVVVVVVGE EEPPRRPPLL HVEEPKIIAK ELLAFLLTTT DDSSSSRRNK KLLSFFISSI IYVVVVVVGE EEPPRRPPLL HVEEAKIIEK GLLGTPPTTT DDSSSSRRTK KLLSLL---- ---------- ---------- ---------- ---------- DDSSSSRRTK KLLSLLISSI IYVVVVVVGE EEPPRRPPLL HVEEPKIIAK ELLAFLLTTT DDPPKKRRRF FLLSLLLGGV VYVVVVTTAD DDPPRRPPLL HVEESEIIEN GLLGFPPTTT DDAAVVRRNK KLLCLLISSI IYVVVVVVGD DDPPRRPPII HTEEPYVVWK GLLANLLTTT DDSSVVRRNK KLLCLLISSI IYVVVVVVGD DDPPRRPPII HTEEPYVVWK GLLANPPTTT DDPPEERRRF FLLSLLVGGI IYVVIITTKN NNPPRRPPLL HVDDPAIIQK GLLAYPPTTT DDPPQQRRRF FLLGIIVGGV VYVVIITTKN NNPPRRPPLL HVEEPEIITK GLLAYPPTTT DDAADDRRRY YLLSLLIGGI IYAAIITTKN NNPPRRPPLL YYDDPKIIEK GLLAYPPTTT DDAADDRRRY YLLSLLIGGI IYAAIITTKN NNPPRRPPLL YYDDPKIIDK GLLAFPPTTT DDPPSSRRRF FLLSLLLGGV VYVVVVTTLD DDPPRRPPLL HVEEAEIIEK GLLGFPPTTT KKPPKKRRSH HLLCLLNDDI IYIIIIVVEE EE--RRIILL ETEEPSLLSL -LLSFPPTTT KKPPKKRRSH HLLCLLNDDI IYVVIIVVEE EE--RRIILL QTEEPSLLAL -LLSFPPTTT ---------- -MMKLLSGGE EGKKVVVVG- ---------- ---------- ---------- KKEETTRRDR RLLCLLNDDI IFVVIITTGD DDPPRRPPLL AVEEG-VVKG DCCTAPPTTT KKTTKKRRDR RLLSLLNDDI IYIILLVVVD DDPPRRPPII VTDDG-VVKS NVVTAPPTTT KKRRGGGGPQ QMMSLLDKKL LYVVTTSSLS SSAAWWKKFF Y-----LLKF VLLAISSTTT ----DDRRRF FFFGLLDNNI IFIIFFVVHD DDPPSSPPLL HTDDT-VVDS GVVVGPPTTT ----DDRRRY YLLGLLDSSI IFVVFFVVHD DDPPAAPPLL STTTD-VVKS GVVVGPPTTT TTVHCGGDDA IYYYYALLGG NEEE--EGGE PGLLLDHSSS SFFFEPPPPG DRGDY----- TTVHCGGDDA IYYYYALLGG GPPP--DGGE PGLLLDHTTT TFFFEPPPPG YRGPY----- TTVHCGGEEG IYYYYTLLGG GAAAGGDGGD APMMMDCTTT TFFFDVVVVG DRGPD----- TTIHCGGDDG IYYYYTLLGG GGGGGGDGGN PPMMMDCTTT TFFFEVVVVG DRGPT----- TTIHCGGEEG IYYYYTLLGG GGGGGGDGGD PPLLLDCTTT TFFFEIIIIG DRGET----- TTVHCGGGGG IYYYYALLGG NAAA--EGGK PGLLLDASSS SFFFEPPPPG ERGPY----- TTVHCGGDDG IYYYYALLGG SPPP--EGGE PGLLLDHNNN NLLLEVVVVG DRGDY----- TTIHCGGDDG VYYYYALLGG SPPP--EGGD PGMMMDHSSS SFFFDPPPPG ERGPQ----- TTSHCLLSSG EVVVVNTTLL GDDD--LQQN KGLLLDGTTT TFFFEVVVVG PGGAP----- TTSHCLLSSG EVVVVSSSLL GDDD--PQQN KGLLLDGTTT TFFFEVVVVG PGGEP----- TTSHCLLSSG EVVVVSTTLL GDDD--SKKN KGLLLDGTTT TFFFEVVVVG PGGAP----- TTSHCLLSSG EVVVVSTTLL GDDD--PEEN KGLLLDGTTT TFFFEVVVVG PGGAP----- TTSHCLLSSG EVVVVSSSLL GDDD--VKKN KGLLLDGTTT TFFFEVVVVG PGGAP----- TTSHCLLSSG EVVVVSSSLL GDDD--VKKN KGLLLDGTTT TFFFEVVVVG PGGAP----- TTSHCLLSSG EVVVVSSSLL GDDD--VKKN KGLLLDGTTT TFFFEVVVVG PGGAP----- TTSHCLLSSG EVVVVSSSLL GDDD--VKKN KGLLLDGTTT TFFFEVVVVG PGGAP----- TTSHCLLTTG EVVVVSTTLL GDDD--PKKN KGLLLDGTTT TFFFEVVVVG PGGSP----- ---------- ---------- ---------- ---------- ---------- ---------- TTSHCLLSSG EVVVVSSSLL GDDD--VKKN KDLLLLPRRR RLLLECCCCG ---------- TTSHCLLSSG DIIIISCCLL GDDD--KEEN AGLLLLDEEE EFFFNVVVVG RLFPS----- TTSHCLLCCG EIIIISSSII GDDD--PYYN KGLLLDGTTT TFFFEVVVVG EGEAP----- TTSHCLLCCG EIIIISSSLL GDDD--PCCN KGLLLDGTTT TFFFEVVVVG EGESQ----- TTSHCLLSSG ELLLLSCCLL GDDD--KDDN EGLLLLDDDD DFFFNVVVVG PGHSL----- TTSHCLLSSG EIIIISCCII GDDD--KDDN EGLLLLDEEE EFFFNVVVVG PGHSL----- TTAHCLLSSG EIIIISCCLL GDDD--EEEN KGLLLLDDDD DFFFNIIIIN PGHSL----- TTAHCRR--G EIIIISCCLL GDDD--EEEN KGLLLLDDDD DFFFNIIIIN PDISL----- TTSHCLLSSG EIIIISCCLL GDDD--KEEN AGLLLLDEEE EFFFNVVVVG PGHSL----- TTSHCLLDDG NIIIISTTLL GEEE--ANNT SGLLLDGTTT TFFFEPPPPG DEKTP----- TTSHCLLDDG NIIIISTTLL GEEE--ADDS SGLLLDGTTT TFFFEPPPPG DGKVP----- ---------- ---------- ---------- ---------- ---------- ---------- TTTHCLLNNG NIIIISIIMM GDDD--AEEN KGEEEFDNNN NFFFELLLLG GDRKL----- TTTHCLLNNG NIIIISVVMM GDDD--AEEY KGLLLFDDDD DFFFNCCCCG GDKKL----- TTADYQQNNT ALLLLDGGVV NEEE--SLLV VLTTTSKEEE ENNNGLLLLA SQFEI----- TTFFALLGGS MMMMMGLLSS NDDD--DDDG RTYYYNDGGG GEEEYVVVVT TADDQGGAAV TTLYALLGGR MLLLLGLLSS NNNN--KDDG RTYYYTNGGG GEEEYVVVVT TDGDRGGAKT --------AF FWWWNNLL-P PNEEEVLLVS SEWAVNN--T IIDKELKKKK D--RYYGNNR --------AF FWWWNNLL-P PSGGGVMMIT SEWTVRR--C FFESELKKKK EGGAYYGNNK --------HF FWWWNNLL-P PRDDDYMMVS SEWALPP--Q FFNVELLLLL ANNKYYGHHR --------HF FWWWNNLL-P PRDDDYMMVT SEWALPP--Q FFNVELLLLL SNNKYYGHHR --------HF FWWWNNLL-P PRDDDYMMVS SEWGLPP--Q FFNVELLLLL SNNKYYGHHK --------AG GWWWHHLL-G GYDDDTLLVT SEWGTDD--M VVDVDLLLLL GAARYYGRRR --------HF FWWWHHLL-G GYDDDTLLLT SEWGTRR--M VVSLDLLLLL AGGKYYGHHR --------AF FWWWHHLL-G GYDDDTMMVT SEWGTNN--M IIGDQLLLLL NKKGYYGRRR --------GF FWYYQQPP-R RHNNNVMMVS TEWAANN--V FFDPHEAAAA -GGLYYGSSR --------GF FWYYQQPP-R RHNNNIMMVS TEWAANN--V FFDPHEAAAA -GGLYYGSSH --------GF FWYYQQPP-R RHNNNVMMIS TEWAANN--V FFDPDEAAAA -GGLYYGSSH --------GF FWYYQQPP-R RHNNNVMMIS TEWAANN--V LLDPDKAAAA -GGLYYGSSH --------GF FWYYQQPP-R RHNNNVMMIS TEWAANN--V LLDPDEAAAA -GGLYYGSSH --------GF FWYYQQPP-R RHNNNVMMIS TEWAANN--V LLDPDEAAAA -GGLYYGSSH --------GF FWYYQQPP-R RHNNNVMMIS TEWAANN--V LLDPDEAAAA -GGLYYGSSH --------GF FWYYQQPP-R RHNNNVMMIS TEWAANN--V LLDPDEAAAA -GGLYYGSSH --------GF FWYYQQPP-R RHNNNVMMIS TEWAANN--V VVNPDEAAAA -GGLYYGKKH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AISAHNN--L RRTDPSAAAA -SSRVVAGGI --------EH HLYYEENNYA AWGGGLFFWS WIQCCLL--F YYTLCTAAAA -SSGVVHVVI --------GF FWYYQQPP-R RHNNNVMMIS TEWGAKK--A FFLMEQAAAA -GGMYYGHHS --------GF FWYYQQPP-R RHNNNVMMIS TEWGAKK--A FFLMDQAAAA -GGHYYGHHS --------GF FWYYQQPP-R RHNNNTMMIS TSWGATT--A FFKLHADDDD -GGLYYGRRH --------GF FWYYQQPP-R RHNNNTMMIS TSWGAKK--A FFQLHADDDD -GGLYYGRRH --------GF FWYYQQPP-R RHKKKTMMIS TSWGAKK--A FFKLHADDDD -GGLYYGSSH --------GF FWYYQQPP-R RHKKKTMMIS TSWGAKK--A FFKLHADDDD -GGLYYGSSH --------GY YWYYQQPP-R RHKKKTMMIS SSWGAAA--A FFTLHQDDDD -GGLYYGRRH --------NF FWYYQQPP-R RRNNNVMMIS TEWGSNN--H IIKPHGEEEE -GGLYYGNNS --------NF FWYYQQPP-R RRNNNIMMIS TEWGSNN--H IIKPHPEEEE -GGLYYGNNS ---------- ---------- ---------S ILRGGVV--T VVRLCPEEEE -PPLVVIKKC --------GY YWYYQQPP-H HFNNNVMMVA SEWGAKK--L FFRPDDDDDD RTTQYYGCCR --------GF FWYYQQPP-Y YFDDDVMMVS SEWGANN--K WWRNDEDDDD MSSQYYGCCR --------QN NHNNNNGG-- -REEEKSSES DRPDEII--M AAESLKTTTT GPPLKKPQQH VVGDVAGGGI IRAALLII-R RKNNNVMMLT SSFTGSSYYM MMFLDEAAAA MKKRFFGNNT TTG-YAGGDV VRAALLPP-R RKNNNLLLVT SSFTGNNYYM MMFLDEAAAA MKKHFFGNNT IIHHWLRRHH SLLTGGEEER MMMAAL---- EPPHHHDPTT KLGFIIVVLS SSSSIWWWNN LLHHWLAHYY AIIDGGQQER MMMVVL---- EPPHHHDPTT KLGFVVVLTS SSSSIWWWQQ LLHHWLRNQQ TIIDGGAAQQ MMMAAL---- EPPHHHDPVV REGFVVVVTE EGGSIWFFHH LLHHWLRNQQ TIIDGGAANQ MMMAAL---- EPPHHHDPVV REGFVVVVTE EAASIWFFHH IIHHWLRNQQ TIIDGGAANQ MMMAAL---- EPPHHHDPSS KDGFCCVVTQ QGGAIFFFEE LLHHWLTHQQ EIIDGGDDEQ LLLVVF---- EPPHHHDPTT KAGFVVVILS SSSSIWWWAA LLHHWLYHQQ TLLDGGAAEQ MMMAAL---- EPPHHHDPTT KAGFMMVVLS SAASIWWWHH LLHHWLRHQQ ALLDGGEEEQ MMMVVL---- EPPHHHDPAA RTGFVVVVLS SAASVWWWGG IIFFWWQIQQ TLLQTT---G LLLIIP---- EFFHHHDPSS ATGFVVALSR RFFYKN---- IIHHWWQIQQ TLLQKK---G LLLIIP---- EFFHHHDPDD ATGFVVALSR RFFYKN---- LLHHWWQIQQ TLLTQQ---G LLLIIP---- EFFHHHNPDD AAGFVVALSR RFFYKN---- LLYYWWQIQQ TLLPQQ---G LLLIIP---- EFFHHHNPDD AAGFVVALSR RFFFKN---- LLYYWWQIQQ TLLSKK---G LLLIIP---- EFFHHHNPDD AAGFVVALSR RFFYKN---- LLYYWWQIQQ TLLSKK---G LLLIIP---- EFFHHHNPDD AAGFVVALSR RFFYKN---- LLYYWWQIQQ TLLSKK---G LLLIIP---- EFFHHHNPDD AAGFVVALSR RFFYKN---- LLYYWWQIQQ TLLSKK---G LLLIIP---- EFFHHHNPDD AAGFVVALSR RFFYKN---- LLHHWWQIQQ TLLLPP---G HHHIIP---- EFFHHHDPAA ASGFVVALSR RFFYKN---- ---------- ---------- ---------- ---------- ---------- ---------- TT-------- ---------- ---------- ---------- ---------- ---------- SSCCDYIIEE SLLPQQ---Q AAAGGANNNI CSSHHHWKNN INDYDDEVFG GGGSDP---- LLNNWWTRQQ TIIDGGEE-G LLLIIP---- EFFHHHDPDD AAGLVVALSR RFFYKE---- LLNNWWTLQQ TIIDGGKK-G LLLIIP---- EFFHHHNPDD ADGLVVALSR RFFYKE---- LLTTILALQQ TLLDGGNN-G LLLLLP---- EFFHHHDPAA KDGFVVALSR RFFFKT---- LLHHYWPIQQ TLLDGGDD-G LLLLLP---- EFFHHHDPAA KDGFVVALSR RFFFKT---- LLHHYWPMQQ LIIDGGEE-G LLLLLP---- EFFHHHDPSS KDGYVVALSR RFFFKN---- LLHHYWPIQQ LIIDGGPP-G LLLLLP---- EFFHHHDPSS KDGFVVALSR RFFFKN---- LLHHYWPLQQ TLLDGGSS-G LLLLLP---- EFFHHHDPSS KDGYVVALSR RFFFKT---- VVHHFWDYQQ TIIDPPQQPG AAALLP---- EFFHHHEPTT SEAFVVALSR RIIHPV---- VVHHFWDHQQ TIIDPPMMPG AAALLP---- EFFHHHEPTT SEAFVVALSR RIIHPD---- KKRRY----- ---------- ---------- ---------- ---------- ---------- LLNNYWQLQQ TIIDGGDD-G LLLTTP---- EFFHHHNPRR ENGYVVAFXX XXXX------ LLNNYWSLQQ TIIDGGSS-G IIITTP---- EFFHHHNPKK KAGFVVALAH HFFKKK---- VVAAV----- ---------- ---------- ---------- ---------- ---------- IIVVWLHPKK VFFNPPGGA- ---------- EFFWWWGSNN ANAFSSALSL LIIYED---- VVVVWLHPKK VFFDPPGGA- ---------- ECCWWWGEAA HNCFTTALSL LIIYED---- VIIPPAEEPP LLEEEILKKK FKKLLVVTDD SSLDDDDKFF LYLLGEQYYF FKKPPVVVVV VIIEEAQQPP FLPPPVLKKK FKKLLVVTDD SSLDDDDRFF LYVLGEQYYH HQQPPRRRRR TIIPPAEEPP ALPPPLLQQQ FGGLLVVTDD SSLDDDDRFF LYVCGEQYYH HNNPPVVVVV TIIPPPEEPP ALPPPLLQQQ FGGLLVVTDD SSMDDDDRFF LYVCGEQYYR RKKPPKKKKK TIIDDPVVPP ALDDDLLKKK FGGLLVVTDD SSLDDDDKYY LYVCGEQYYM MNNPPVVVVV VIIPPAEEAA ALPPPVLKKK FKKLLVVTDD SSMDDDDRFF LYVCGDQYYF FEEPPKKKKK VIIPPAEEPP ALPPPILKKK FKKLLVVTDD SSVDDDDRFF LYVCGEQYYF FNNPPRRRRR VIIPPAEEPP ALPPPLLKKK FGGLLVVTDD SSLDDDDRFF LYVCGEQYYF FNNPPRRRRR -SSVVEKKVV IKVVVKGWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYQ QKKPPRRRRR -SSVVEKKVV IKVVVKGWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYK KKKPPRRRRR -SSVVEKKVV IKVVVKGWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYQ QRRPPRRRRR -SSAAQKKVV IKVVVKGWWW LPPLLIITDD SSLDDDDHFF LYFNGDQYYQ QRRPPRRRRR -SSVVEKKVV IKVVVKGWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYQ QRRPPRRRRR -SSVVEKKVV IKVVVKGWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYQ QRRPPRRRRR -SSVVEKKVV IKVVVKGWWW LPPLLIIT-- ---------- ---------- ---------- -SSVVEKKVV IKVVVKGWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYQ QRRPPRRRRR -SSVVEKKVV IKVVVKGWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYK KRRPPRRRRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -VVLLKRRKK LAVVVAKFFF VVVEEFFPPP FFFSDDDLLL IIFS------ ---------- -AAAAEKKVV IKVVVEGWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYR RNNPPKKKKK -AAAAEKKVV IKVVVEGWWW MPPLLIITDD SSLDDDDRFF LYFNGDQYYR RNNPPKKKKK -SSHHELLAA ILVVVQNWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYK KNNPPVVVVV -NNHHEIIVV ILVVVQNWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYK KNNPPKKKKK -SSYYEIIVV ILVVVENWWW LPPLLIITDD SSLDDDDRFF LYFNGDQYYK KNNPPVVVVV -SSHHEVVVV ILVVVENWWW LPPLLIITDD SSLDDDDRFF IYFNGDQYYK KNNPPVVVVV -SSHHEVVAA ILVVVRNWWW LPPLLIITDD SSLDDDDRYY LYLNGDQYYA AKKPPVVVVV -AAAATLLVV AKVVVSGWWW LPPLLIITDD SSMDDDDRFF LYVCGDQYYL LKKVVKKKKK -TTAASLLVV AKVVVENWWW LPPLLIITDD SSMDDDDRFF LYVCGDQYYK KNNPPKKKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- --GGGENGGG IEEMMMMTDD SSLDDDDRYY LYFNGDQYYA ANNPPRRRRR FKKKKVIIDD IVTTTGSGGG AEEMMIISDD SSLDDDDRFF LYVCGDQYYE ENNPPKKKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- -KVVVADIII NPPLLPPVDD AAADDDDQTT LWISGKLFFH HKKPPFFFFF ---------- -KVVVADIII EPPLLPPVDD SSNDDDDSRR LWVTGKLFFH HHHPPRRRRR KKKLGIAAAD DHP------- -----AAGGG HKKTTTLLLL IISRDRRNSL WWNNQQQFFP RRKIGLEEEP PHP------- -----SSGGG AEETTTIIII VVSRDRRNSL WWNNQQQFFP SSRIGIAAAP PHP------- -----NNGGG RTTAAAVVVV IISRDRRNSL WWDDQQQFFP SSHIGITTTP PHP------- -----NNGGG KAAAAAVVVV IISRDRRNSL WWDDQQQFFP KKEIGITTTP PHP------- -----NNGGG KTTGGGVVVV IISRDKRNSL WWEEQQQFFP KKRIGIAAAT THP------- -----KKNNN GAANNNVVVV IISRDRRNSL VVPPQQQFFP KKQIGIAAAG GHP------- -----TTSSS AEENNNVVVV IISRDRRNSL WWEEQQQFFP SSRLGIAAAA AHP------- -----AASSS GPPNNNVVVV VVSRDRRNSL WWEEQQQFFP QQFLGSGGGG GSVLL-DLTC CQEPVKKGGG KRRPPPIIII LLSLDKRTSL WWKKQQQFF- QQFLGSGGGG GSVLL-DLTC CQEPVKKGGG KRRPPPIIII LLSLDKRTSL WWKKQQQFF- QQFLGSGGGG GPVLL-DLKS SQEPVKKGGG KKKPPPIIII LLSLDKRTSL WWKKQQQFF- QQFLGSDDDG GPVLL-DLDS SQEPVKKGGG KQQAAAIIII LLSLDKRTSL WWKKQQQFF- QQFLGSGGGG GPVLL-DLKS SQEPVKKGGG KRRAAAIIII LLSLDKRTSL WWKKQQQFF- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQFLGSGGGG GPVLL-DLKS SQEPVKKGGG KRRAAAIIII LLSLDKRTSL WWKKQQQFF- QQFLGSGGGG GPVLL-DLKS SQEPVKKGGG KRRPPPIIII LLSLDKRTSL WWKKQQQFF- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQFLGSGGGG GPVLL-DLEC CQDPIKKGGG KKKPPPIIII LLSLDKRNSL WWKKQQQFF- QQFLGSGGGG GPVLL-DLEC CQDPTKKGGG KIIPPPIIII LLSLDKRSSL WWKKQQQFF- QQWVGLGGGS SPVII-EKTW WQDVEQQGGG QKKRRRIIII LLTLDKRNSL WWKKQQQFF- QQWAGLGGGS SPVVV-DETW WQDVEQQGGG KKKRRRIIII LLSLDKRNSL WWKKQQQFF- QQWVGLGGGS SPVVV-ENSF FQDVQKKGGG KSSRRRIIII LLSLDKRNSL WWRRQQQFF- QQWVGLGGGS SPVVV-ENTF FQEVQKKGGG KSSRRRIIII LLSLDKRNSL WWVVSSSFF- QQWAGLGGGS SEVVV-EKEE EQSVQKKGGG HRRRRRIIII LLSLDKRNSL WWEEQQQFFG QQYIGSEEES SNVLL-G--- -PEAYKKGGG RKKEEELLLL LLSLDKRTSL WWDDQQQFF- QQFIGSEEET TTVLL-ED-- -EPAYKKGGG RQQEEELLLL LLSLDKRTSL WWDDQQQFF- ---------- ---------- ---------- ------IIII LLSVDKRNSF WWKKQQQFF- QQFLGADDDA APRLL-DLKE EAEPFKKGGG RRRLLLLLLL LLSLDRRSSL WWKKQQQFF- QQFLGADDDL LPNVVEDLKE ERPAYKKGGG RRREEELLLL LLSLDKRSSL WWKKQQQFF- ---------- ---------- ---------- ---------- ---------- ---------- EEVIDQ---- ---------- ---------- ------VVVV QQSWDKRSSL WW-------- EETIGQ---- ---------- ---------- ------VVVV SSSWDQRSSL WW-------- PGLKVVVVLN NN------SG GGEEIKKKKE EDDDFE---- RRSQQGGDAA SSSCC----- PGLRAAAAVN NN------EG GGEELKKKKE EDDDFR---- RRAQQGGDAA SSSCC----- PGVPVVVVAH GG------DG GGTTLDDDDD DEEEFDG--- RRAQQGGDCC SSSCCVKK-- PGVPVVVVAN GG------NG GGEELKKKKD DSSSFDG--- RRAQQGGDCC SSSCCV---- PDRGVVVVAN GG------NG GGTTLKKKKD DDDDFAG--- RRSQQGGDCC SSSCCV---- PGIDVVVVLD GG------NG GGEEFPPPPK KEEEWKG--- RRPQQGGDCC SSSCC----- PGIKVVVVVD NN------DG GGQQFPPPPN NDDDFE---- RRVQQGGDAA SSSCC----- PGIRAAAAAE DD------GG GGSSLPPPPG GEEEVDG--- RRPQQGGDSS SSSCC----- -DLISSSSML VVDDDTTTNG GGKKLPPPPN NDDDFKEPPP LLAEEGGDCC SSIII----- -NLISSSSML IIDDDTTTNG GGKKLPPPPN NDDDFKEPPP LLAEEGGDCC SSIII----- -DLISSSSML IIDDDTTTKG GGKKLPPPPN NDDDFKEPPP LLAEEGGDCC SSILL----- -DLISSSSML IIDDDTTTKG GGTTLPPPPN NDDDFKEPPP LLAEEGGDCC SSILL----- -DLISSSSML VVDDDTTTKG GGKKLPPPPN NDDDFKEPPP LLAEEGGDCC SSIII----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -DLISSSSML VVDDDTTTKG GGKKLPPPPN NDDDFKEPPP LLAEEGGDCC SSIII----- -DLISSSSML IIDDDTTTKG GGKKLPPPPN NDDDFKEPPP LLAEEGGDCC TTILL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -DMISSSSML IIDDDTTTKG GGKKLPPPPN NDDDFKEPPP LLAEEGGDCC SSIVV----- -DLLAAAAML IIDDDTTTKG GGKKLPPPPN NDDDFKEPPP LLAEEGGDCC TTIII----- -GLVSSSSIL IIDDDTTTKG GGKKIPPPPN NDDDFAEPPP LLAEEGGDCC TTIII----- -KLVSSSSIL IIDDDTTTNG GGKKIPPPPN NDDDFAEPPP LLAEEGGDCC TTIII----- -ELMSSSSII IIDDDTTTKG GGSSIPPPPN NDDDFDEPPP LLAEEGGDCC TTIII----- -EIMSSSSII IIDDDTTTKG GGTTIPPPPD DDDDFDEPPP LLAEEGGDCC TTIII----- GDLVSSSSML IIDDDTTTKG GGSSIPPPPN NDDDFAEPPP LLAEEGGDCC TTIII----- -EHVAAAAMV VVNNDPPPSG GKEEIRRRRD DDDDFKIEEE LLAEEGGDCC TTIII----- -ENVAAAAML IIDDDPPPTG GHVVIKKKKN NDDDFKVPPP LLAEEGGDCC TTIII----- -NVVSSSSML IIDDDTTTKG GGTTVKKKKN NDDDFKEPPP LLADDCCDSS TTIAA----- -EMVGGGGIV LLDDDVVVNG GGKKLEEEEN NDDDFGEPPP LLPEE----- ---------- -KMVGGGGIV IIDDDTTTNG GGSSLEEEED DDDDFNEPPP LLPEEGGDCC TTILLA---- ---------- ---------- ---------- ---------- ---------- ---------- ----KKKKDA YYLLAYYYWD DGEELEEEED DDDDFELGGG RRAIISSALL YY-------- ----KKKKDE FFLLLYYYWD DGEELEEEEQ QDDDFAEKKK RRPQQAAALL YYPGGRLLQQ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- RVVEEEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSSAAAKK QQPSSEACRR RVVPPGTAAA ARLAADAMQS SLRTALSSLL TPPPGSPRRK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KAYEEWIIIQ QVASSPPSRK KVPPPLLVVI SAAAVAAVVV VVVPPPSSQA QAWWWWLPGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------ARR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --GGGGLGEE ---------- ---------- ---------- ---------- ---------- -LNNNNSQCC ---------- ---------- ---------- ---------- ---------- ---------- --MGGALLLN NNTTTPPPPA AHPPPVVPPT LVVVRPPTTT IIINNNVVPP PPHHHHARSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MKRR ---------- ---------- ---------- ---------- ---------- ------MKFF ---------- ---MMIIKDP PPYSSAAMAP EEDLLLVVAA LLLYYTGINA ADFFIVVVVN ---------- -----MMKDP PPYTTAAMAP EEDIIIVVAA LLLYYVGVNP PDFFLVVVVD ---------- -------RDP PPHSSAAMAP EEEFFFTTLL LLLSSPD--P PDAALVVVVK ---------- -------RDP PPHSSAAMAP EENFFFTTLL LLLSSPD--P PDAALVVVVK ---------- -------RDP PPYSSAAMGP EEKLLLTTLL LLLSSPD--P PDGGLVVVVD ---------- -----MMKDP PPYSSAAAAP EETIIIVVAA FFFDDPE--P PDAAIVVVVD ---------- -----MMRDP PPYSSAAVAP EEKLLLVVVV LLLNNPMG-P PDAAMVVVVD ---------- -----MMRDP PPYSSAAMAP EERLLLVVAA LLLDDPG--P PDAALVVVVD ---------- -MATTCC-GP PPPPPMMKGP EEEIIILLPP IIIYYRNTEP PDYYLTTTTD ---------- ---------- -------MGP EEEIIILLPP IIIYYRNIEP PDYYLTTTTD HGGVVAAPAA LHSTTCC-GP PPPPPMMKGP EEEIIILLPP IIIYYGNIEP PDYYLTTTTD ---------- ---------- -----MMKGP EEEIIILLPP IIIYYRNIEP PDYYLTTTTD ---------- -MATTCC-GP PPSPPMMKGP EEEIIILLPP IIIYYRNTEP PDYYLTTTTD EGGTTSSVAA MTATTCC-GP PPSPPMMKGP EEEIIILLPP IIIYYRNTEP PDYYLTTTTD ---------- -MATTCC-GP PPSPPMMKG- ---------- -------TEP PDYYLTTTTD ---------- -MATTCC-GP PPSPPMMKGP EEEIIILLPP IIIYYRNTEP PDYYLTTTTD PGGAAWWFLL QTATTCC-GP PPPPPMMKGP EEEIIILLPP IIIYYRNTEP PDYYLTTTTD GFFTTEELHH CSPTTCC-GP PPSPPMMKGP EEEIIILLPP IIIYYRNTEP PDYYLTTTTD ---------- -MATTCC-GP PPSPPMMKGP EEEIIILLPP IIIYYRNTEP PDYYLTTTTD VLLIIGGAAA ENGKKCCAGP PPAPPMMEGP EEKLLLVVTT VVVYYNGINL LDYYLTTTTD ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MAACC-GP PPKPPMMKGP EEEIIILLPP IIIYYRSINP PDYYLTTTTD -----TTVLL GKS--NNKGP PPAPPMMSGP EESLLLVVTT VVVYYAGIEP PDYYLTTTTD -----TTVLL AVNNNQQKGP PPAPPMMSGP EETLLLVVTT VVVYYAGIEP PDYYLTTTTD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----RRVGP PPAPPMMSGP EEKLLLVVTT VVVYYTGIDP PDYYLTTTTD ---------- -NGAACCAGP PPAPPMMEGP EEKLLLVVTT VVVYYNGINP PDYYLTTTTD ---------- -CGLLCC-GP PPAPPIIKGP EEEVVVVVTT PPP----ADP PDAAITTTTN ---------- -CPLLCC-GP PPAPPIIKGP EEEVVVVVTT PPP----RDP PDAAITTTTN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMEEKGP PPAPPVVRGP EEKLLLVVVV VVVQQPNEEG GDYYLTTTTD ---------- ---------- -----MMRGP EEKLLLTTVV VVVQQPNEPG GDYYLTTTTD ---------- --------MP PPI--LLILD RRFLLLSSNN LLLHHGDQYI ITDDRNNNNV FGG------- LLAMMLLAAD DDCSSPPKTG EEEFFFVVWW LLLGGVEGDQ QDKKLTTTTR VSSSSFFALL LLALLAAVAD DDCSSKKKTG EEDYYYVVWW LLLGGAEGDQ QDKKLTTTTN NPKKKSTTTT TIIVKKKVVE ELLLPYYNNL HHFFWWNNCC A-PPGG---K NNIIRRRFII DPKKKSTTTT TVVIKKKLLD DLLLPYYGGL HHFFWWNNCC A-PPAA---K FFLLRRRYII KPGGGSTTTT TIIVTTTVVT TMMMPNNGGF HHFFWWNNCC S-PPTTGGGH FFLLRRRFII KPGGGSTTTT TIIVTTTVVT TMMMPNNGGF HHFFWWNNCC A-PPAAGGGH FFIIRRRYII DPTTTSKKKK KIIVQQQLLI IMMMPNNGGF HHFFWWNNCC A-PPTTGGGH FFLLRRRYII DPAAASRRRR RIIVQQQVVA AMMMPHHGGL HHFFWWNNCC C-PPAAPPPH HHMMRRRYVV DSQQQSTTTT TVVVVVVTTD DMMMPYYGGL HHFFWWNNCC M-PPAAPPPH HHVVRRRYVV DPDDDSTTTT TIIVRRRVVE EMMMPNNAAL HHFFWWNNCC A-PPAAPPPH HHVVRRRYII DPKKKSQQQQ QVVIRRRLLP PMMMPYYKKL HHSSWWNNCC C---FFGGGD TTKKRRNKII DPKKKSHHHH HVVIRRRLLP PMMMPHHKKL HHSSWWNNCC C---FFGGGD TTKKRRDKII DPKKKSQQQQ QVVIRRRLLP PMMMPNNRRL HHSSWWNNCC C---FFGGGD TTKKRRTKMM DPKKKSQQQQ QVVIRRRLLP PMMMPHHKKL HHSSWWNNCC C---YYGGGD TTKKRRTKVV DPKKKSQQQQ QVVIRRRLLP PMMMPNNKKL HHSSWWNNCC C---FFGGGD TTKKRRTKVV DPKKKSQQQQ QVVI------ ---------- ---------- ---------- ---------- DPKKKSQQQQ QVVIRRRLLP PMMMPNNKKL HHSSWWNNCC C---FFGGGD TTKKRRTKVV DPKKKSQQQQ QVVIRRRLLP PMMMPNNKKL HHSSWWNNCC C---FFGGGD TTKKRRTKVV DPKKKSQQQQ QVVIRRRLLP PMMMPYYKKL HHSSWWNNCC C---FFGGGD TTKKRRNKVV DPKKKSQQQQ QVVIRRRLLP PMMMPNNKKL HHSSWWNNCC C---FFGGGD TTKKRRTKVV DPKKKSQQQQ QVVIRRRLLP PMMMPNNKKL HHSSWWNNCC C---FFGGGD TTKKRRTKVV DPSSSSTTTT TVVIRRRLLP PVVVIHHGGL HHSSWWNNCC C---HHGGGD SSAARRRFII ---------- ---------- -MMMPNNNNL HHSSWWNNCC C---YYGGGD SSKKRRNKII DPKKKSSSSS SVVIRRRLLP PMMMPNNNNL HHSSWWNNCC C---YYGGGD SSKKRRNKII DPSSSSTTTT TVVIRRRLLP PVVVPYYGGL HHTTWWNNCC C---HHGGGD SSAARRRFII DPNNNSTTTT TVVIRRRLLP PVVVPYYGGL HHTTWWNNCC C---HHGGGD SSAARRRFII ---------- ---------- -MMMPFFGGL HHSSWWNNCC C---HHGGGD SSAARRRYVV DPSSSSSSSS SVVIRRRLLP PMMMPFFGGL HHSSWWNNCC C---HHGGGD SSVVRRRYVV DPNNNSTTTT TVVIRRRLLP PVVVTHHGGL HHSSWWNNCC C---HHGGGD SSAARRRFII NPEEESTTTT TVVIRRRVVD DVVVPHHGGV HHTTWWNNCC C---HHDDDK TTEERRSHII NPEEESTTTT TIIIRRRVVD DVVVPNNGGV HHTTWWNNCC C---HHDDDK TTEERRSHII ---------- ---------- ---------- ---------- ---------- --------VV DPAAASTTTT TVVIRRRTTY YTTTNSSHHL HHSSWWNNCC CVPPGGGGGK VVPPRRDRVV DPEEESTTTT TIIVRRRTTF FTTTNRRGGL HHSSWWNNCC CVDDSSSSSK VVPPRRDRVV VGQQQVLLLL LVVLDDDGGP PVVVKVVEEE DDSSPPTTRR K-----GGGK VVQQGGPQLL RPGGGSTTTT TVVISSSVVS SVVVGGGRRA HHGGFFSS-- ---------- ----RRRFWW NPKKKSQQQQ QVVVTTTLLS SVVVGGGRRA HHSSFFTT-- ---------- ----RRRYWW IVPPPGGLLS SIIIIPPPPR RIKKIEEPEE VVVKKKKKVS YSSRRLLLTH HHHHGPDIIY IVPPPAALLS SIIIVPPKKR RVKKVEEPEV AAAVVGGGRT YTTKKYYYTH HHHHGPDIIY IIPPPGGLLS SIVVIPPPPT TIKKIEEPDE IIILLAAAKT YSSRRPPPTH HHHHGPEIIY IIPPPGGLLS SIIIIPPPPT TIKKIEEPEE VVVFFKKKKT YSSRRPPPTH HHHHGPDIIY IIPPPGGIIS SIIIV--PPL LIKKIEEPEE VVVFFAAAKT YSSRRPPPTH HHHHGPEIIY VVPPPGGLLS SIIILPPPPL LLKKIEEPET LLLAAEEERT YSSRRPPPTH HHHHGPGIIY VVPPPDDIIS SIIILPPPPT TVKKIDDPNE LLLAAEEERT YAARRPPPTH HHHHGPDIIY IVPPPGGIIS SIIIVPPPPR RIKKIEEPEE LLLHHRRRRT YSSRRPPPTH HHHHGPDVVY ILPPPGGLLS SIVVVSSPPR RLKKIEEASE IIIQQAAAKC VSSNNTTTTH HHHHLASEEV ILPPPSSIIS SIVVVSSPPR RLKKIEEPNE IIIHHAAAKC LGGNNLLLTH HHHHLASEEV MLPPPCCLLS SIVVVSSPPR RLKKIEEAED IIIHHAAAKC LGGYYVVVTH HHHHLASEEV VLPPPAALLS SIVVVTTPPR RLKKIEEPKD IIIHHTTTKC LGGFFFFFTH HHHHLPSEEV VLPPPSSLLS SIVVVSSPPR RLKKIEEPED IIIHHAAAKC LAAFFLLLTH HHHHLASEEV ---------- ---------- -------PKD IIIHHAAAKC LAAFFLLLTH HHHHLASEEV VLPPPSSLLS SIVVVSSPPR RLKKIEEPKD IIIHHAAAKC LAAFFLLLTH HHHHLASEEV VLPPPSSLLS SIVVVSSPPR RLKKIEEPKD IIIHHAAAKC LAAFFLLLTH HHHHLASEEV VLPPPSSFFS SIVVVTTPPR RLKKIEEAKD IIIHHEEEKC LGGTTPPPTH HHHHLPTEEV VLPPPSSLL- ---------- ---------- ---------- ---------- ---------- VLPPPSSLLS SIVVVSSPPR RLKKIEEPKD IIIHHAAAKC LAAFFLLLTH HHHHLASEEV ILPPPSSLLG GVVVVTTPPR RLKKVEESED IIIAAEEENI LGGFFPPPTH HHHHLASDDI ILPPPCCLLS SIVVVTTPPR RIKKVEEPYE VVVFFWWWKC LAANNLLLTH HHHHLGCEEI ILPPPCCLLS SIVVVSSPPR RIKKVEEPYE VVVFFWWWKC LAANNPPPTH HHHHLGCEEI IAPPPSSLLG GIVVITTPPR RLKKVDDPAD IIIIIQQQKT LAAYYPPPTH HHHHLASEEL IVPPPGGIIG GVVVITTPPR RLKKVEEPED IIISSTTTKT LAAYYPPPTH HHHHLASEEI VLPPPSSLLG GIAAIEEPPR RLKKVDDPKE IIIAAEEEKT LAAYYPPPTH HHHHLASEEI VLPPPSSLLG GIAAIEEPPR RLKKVDDPKE IIIAADDDKT LAAFFPPPTH HHHHRT-EEI ILPPPSSLLG GVVVVKKPPR RLKKVEEAED IIIAAEEEKT LGGFFPPPTH HHHHLASEEI IVPPPCCLLD DIIIINN--R RLHHIEEPSK LLLHHSSSLN LSSFFPPPTH HHHHLADNNI IVPPPCCLLD DIVVINN--R RLHHIEEPSK LLLHHAAALN LSSFFPPPTH HHHHLADNNI VPRRRKKLLG GEKKVGG--- ---------- ---------- ---------- ---------- VLPPPCCLLD DIVVITTPPR RLKKIEEG-D VVVLLKKKGA CTTAAPPPTH HHHHLPNNNI VLPPPSSLLD DIIILTTPPR RIKKIDDG-D VVVLLKKKSH VTTAAPPPTH HHHHLANNNI LQLLLSSLLK KLVVTYYAAW WFPP-----D LLLIIKKKFL LAAIISSSTD DDDDQPNAAL WTGGGGGLLN NIIIFSSPPS SLKKIDDT-F VVVKKDDDSG VVVGGPPPTF FFFFLPGMMM WAGGGGGLLS SIVVFSSPPA ALKKITTD-F VVVEEKKKSG VVVGGPPPTY YYYYLPGMML ISALLLE--- -G-EGGDHHH YYYSELIDRQ YY-------- ----LLAYYD WWNLLL-NNE ISALLLP--- -GREGGDHHH DDDTEIVYRQ YY-------- ----FFAYYD WWNLLL-SSG VSTLLLAKKK KGTDGGDCCC EEETDLIDRQ DD-------- ----KKHYYD WWNLLL-RRD VSTLLLGKKK KGTNGGDCCC EEETELIDRQ TT-------- ----LLHYYD WWNLLL-RRD VSTLLLGEEE EGTDGGDCCC EEETELMDRQ TT-------- ----KKHYYD WWNLLL-RRD VTALLLA--- -G-KGGDAAA QQQSELVERQ YY-------- ----FFAYYD WWHLLL-YYD ISALLLP--- -G-EGGDHHH DDDNELIDRQ YY-------- ----LLHYYD WWHLLL-YYD VSALLLP--- -G-DGGDHHH EEESDLVERQ QQ-------- ----LLAYYD WWHLLL-YYD MVNTTTD--- -QGNGGDGGG EEETEKKPGS PP-------- ----MMGYYD WWQPPP-HHN MISSSSD--- -QGNGGDGGG EEETEKKPGA PP-------- ----MMGYYD WWQPPP-HHN MISTTTD--- -KGNGGDGGG EEETEKQPGA PP-------- ----MMGYYD WWQPPP-HHN MVSTTTD--- -EGNGGDGGG KKKTEKQPGA PP-------- ----LLGYYD WWQPPP-HHN MISSSSD--- -KGNGGDGGG EEETEKRPGA PP-------- ----SSGYYD WWQPPP-HHN MISSSSD--- -KGNGGDGGG EEETEKRPGA PP-------- ----LLGYYD WWQPPP-HHN MISSSSD--- -KGNGGDGGG EEETEKRPGA PP-------- ----LLGYYD WWQPPP-HHN MISSSSD--- -KGNGGDGGG EEETEKRPGA PP-------- ----LLGYYD WWQPPP-HHN MISTTTD--- -KGNGGDGGG EEETEKRPGA PP-------- ----MMGYYD WWQPPP-HHN ---------- ---------- ---------- ---------- ---------- ---------- MISSSSD--- -KGNGGLPPP ---RES---- ---------- ---------- ---------- MISCCCD--- -EGNAALDDD SSSENKNRLI SS-------- ----KKERRT LLENNNYWWG MISSSSD--- -YGNGGDGGG EEETEKAEGA PP-------- ----FFGYYD WWQPPP-HHN MISSSSD--- -CGNGGDGGG EEETEKVEGA QQ-------- ----FFGYYD WWQPPP-HHN MISCCCD--- -DGNAALDDD SSSDNKKPGP LL-------- ----FFGYYD WWQPPP-HHN MISCCCD--- -DGNAALDDD SSSENKKPGP LL-------- ----FFGYYD WWQPPP-HHN LVSCCCD--- -EGNAALDDD SSSDNKKPGP LL-------- ----FFGYYD WWQPPP-HHK LVSCCCD--- -EGNAALDDD SSSDNKKPDP LL-------- ----YYGYYH WWQPPP-HHK MISCCCD--- -EGNAALDDD SSSENKKPGP LL-------- ----FFGYYD WWQPPP-HHK MISTTTE--- -NGTPPDGGG KKKTEKADEV PP-------- ----FFNYYD WWQPPP-RRN MISTTTE--- -DGSPPDGGG KKKTEKADGV PP-------- ----FFNYYD WWQPPP-RRN ---------- ---------- ---------- ---------- ---------- ---------- MISIIID--- -EGNAAFDDD KKKNEVRGDA LL-------- ----CCGYYD WWQPPP-FFN MISVVVD--- -EGYAAFDDD SSSDNIKGDA LL-------- ----CCGYYD WWQPPP-FFD KQDGGGE--- -LSVPPSKKK HHHEGSASQE II-------- ----LLQLLS HHNGGG-RRE ITGLLLD--- -DHGGGNDDD DDDGYAPTAM QQGAAVAVGG DDAGYYGYYD RRLIII-KKN ITGLLLN--- -DHGGGTNNN AAAGYAPTDL RRGAAIKTGG --AGYYDYYD RRLPPP-KKN LVVSVVPTII IDDLKEL-RY GGNIWLRKKR RKKHLTLENM ------LLPP LHHDDDPTLM MIISVVPCFF FEEFSELGAY GGNLWLAKKR RRRYIDLQHM ------VVPP LHHDDDPTLM MVVSLLPQFF FNNIVELNKY GGHLWLRAAR RRRQIDLAHM ------VVPP AHHDDDPVEY MVVSLLPQFF FNNIVELNKY GGHLWLRAAR RRRQIDLAHM ------VVPP AHHDDDPVEY MVVSLLPQFF FNNIVELNKY GGHIWLRDDR RKKQIDLAHM ------IIPP AHHDDDPSDY LVVSTTPMVV VDDLVDLARY GGRLWLTRRR RRRQIDFDHL ------LLPP AHHDDDPTAY LLLSTTPMVV VSSVLDLGKY GGHLWLYRRR RRRQLDLAYM ------LLPP AHHDDDPTAY MVVSTTPMII IGGLDQLKGY GGRLWLRRRR RRRQLDVEHM ------LLPP AHHDDDPATY MVVTAAPVFF FDDNPHEGLY GGSIWWQRRH HEEQLQM-DL -----LIIFF LHHDDDPSTQ MVVTAAPVFF FDDNPHEGLY GGSIWWQRRH HEEQLQM-DL -----LIIFF LHHDDDPDTQ MIITAAPVFF FDDNPDEGLY GGSLWWQRRH HEEQLTL-DL -----LIIFF LHHNNNPDAQ MIITAAPVLL LDDNPDKGLY GGSLWWQRRR REEQLPL-DL -----LIIFF LHHNNNPDAQ MIITAAPVLL LDDNPDEGLY GGSLWWQHHH HEEQLSL-DL -----LIIFF LHHNNNPDAQ MIITAAPVLL LDDNPDEGLY GGSLWWQRRH HEEQLSL-DL -----LIIFF LHHNNNPDAQ MIITAAPVLL LDDNPDEGLY GGSLWWQRRH HEEQLSL-DL -----LIIFF LHHNNNPDAQ MIITAAPVLL LDDNPDEGLY GGSLWWQRRH HEEQLSL-DL -----LIIFF LHHNNNPDAQ MIITAAPVVV VNNNPDEGLY GGKLWWQRRH HEEQLLM-DH -----LIIFF LHHDDDPASQ ---------- ---------- ---------- ---------- ---------- ---------- ---AHHSLRR RTTRDPSSRV AAGT------ ---------- ---------- ---------- FWWWCCSFYY YTTELCTSGV HHVSDYIMMR RVVELPL-DA NIIIILLLSS IHHWWWKNNQ MIITAAPAFF FLLKMEQGMY GGHLWWTEEH HRRQIDLEDL -----LIIFF LHHDDDPDAQ MIITAAPAFF FLLKMDQGHY GGHLWWTEEH HRRQIDLKDL -----LIIFF LHHNNNPDDQ MIITAAPAFF FKKDLHAGLY GGRLILARRG GEEQLDLNTL -----LIIFF LHHDDDPADT MIITAAPAFF FQQNLHAGLY GGRLYWPGGG GEEQLDLDKL -----LIIFF LHHDDDPADT MIITAAPAFF FKKDLHAGLY GGSLYWPGGG GEEQIDLETL -----LIIFF LHHDDDPSDT MIITAAPAFF FKKNLHAGLY GGSLYWPGGG GEEQIDLPTL -----LIIFF LHHDDDPSDT MIISAAPAFF FTTDLHQGLY GGRLYWPGGG GEEQLDLSTL -----LVVFF LHHDDDPSDT MIITSSPHII IKKNPHGGLY GGNVFWDSSK KKKQIDLQLA -----LVVFF LHHEEEPTEH MIITSSPHII IKKNPHPGLY GGNVFWDTTK KKKQIDLMRA -----LVVFF LHHEEEPTEH ---IGGPTVV VRRELCPPLV IIKKY----- ---------- ---------- ---------- MVVSAAPLFF FRRHPDDTQY GGCLYWQEER REEQIDLDDL -----LIIFF LHHNNNPRNQ MVVSAAPKWW WRRKNDESQY GGCLYWSTTQ QTTQIDLSDI -----LIIFF LHHNNNPKAE SEEDEEPMAA AEEESLKPLK PPQVV----- ---------- ---------- ---------- MLLSGGWMMM MFFMLDEKRF GGNIWLHTTR RQQKFNVGP- -----LIIFF PWWGGGSNNY LVVSGGWMMM MFFMLDEKHF GGNVWLHTTK KQQKFDVGP- -----LIICC AWWGGGEANY GGGGIINMMV LLLLLKDLSS SIILLLFEED AEEKIIIIIP AEEPPLGLLP PPPILLPPKA GGGGVVNVVL TTTTTKDLSS SIILLLFEED AEERIIIIIE AQQPPFGLLP PPPVLLDDKM GGGGVVGVVV TTTTTTNLEE SIITTTWEEG VKKKAAIIIP AEEPPAALLP PPPLLLGGGA GGGGVVGVVV TTTTTTNLEE SIITTTWEEG AEEKAAIIIP PEEPPAKLLP PPPLLLGGGA GGGGCCGVVV TTTTTTNLQQ AIITTTWDDD AKKKIIIIID PVVPPAALLP PPPLLLGGGA GGGGVVNCCI LLLLLKDLSS SIITTTYDDK VRRKIIIIIP AEEAAAPLLP PPPVLLGGKA GGGGMMNCCV LLLLLKDLSS SIILLLYDDN LKKKIIIIIP AEEPPAELLP PPPILLPPKA GGGGVVGVVV LLLLLEDLSS SVVLLLHQQN IRRKIIIIIP AEEPPAPLLP PPPLLLDDGA GGGGVVGCCL SSSSSNIQRR YKKEEEG--- ----TTSSSV EKKVVIVKKK KKKKGGMMPE GGGGVVGCCL SSSSSNIQRR YKKEEEG--- ----TTSSSV EKKVVIVKKK KKKKGGMMPE GGGGVVGCCL SSSSSTIQRR YKKQQQG--- ----TTSSSV EKKVVIVKKK KKKKGGMMPE GGGGVVGCCL SSSSSTIQRR FKKEEEG--- ----TTSSSA QKKVVIVKKK KKKKGGMMPE GGGGVVGCCL SSSSSTIQRR YKKEEEG--- ----TTSSSV EKKVVIVKKK KKKKGGLLPE GGGGVVGCCL SSSSSTIQRR YKKEEEG--- ----TTSSSV EKKVVIVKKK KKKKGGLLPE GGGGVVGCCL SSSSSTIQRR YKKEEEG--- ----TTSSSV EKKVVIVKKK KKKKGGLLPE GGGGVVGCCL SSSSSTIQRR YKKEEEG--- ----TTSSSV EKKVVIVKKK KKKKGGLLPE GGGGVVGCCL SSSSSTIQRR YKKEEEG--- ----TTSSSV EKKVVIVKKK KKKKGGMMPE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDDDDDVVVV FFFFFSGRGG SDDDDDY--- ----AAVVVL KRRKKLLAAV VVVAKKGGVS GGGGVVGCCL SSSSSTVFRR YKKKKKG--- ----KKAAAA EKKVVIVKKK KKKEGGAAPE GGGGVVGCCL SSSSSSIFRR YKKKKKG--- ----KKAAAA EKKVVIVKKK KKKEGGPPPE GGGGVVGSSL SSSSSNMIRR FKKQQQG--- ----SSSSSH ELLAAIVLLK KKKQNNIIPE GGGGVVGSSL SSSSSNMIRR FKKQQQG--- ----SSNNNH EIIVVIVLLK KKKQNNFFPE GGGGVVGSSL SSSSSNMIRR FKKSSSD--- ----TTSSSY EIIVVIVLLK KKKENNIIPE GGGGVVGSSL SSSSSNMIRR FKKSSSE--- ----TTSSSH EVVVVIVLLK KKKENNIIPE GGGGVVGCCL SSSSSNMVRR FKKAAAG--- ----SSSSSH EVVAAIILLK KKKRNNIIPE AAAAVVGCCL SSSSSGIFRR HPPEEEN--- ---TTTAAAA TLLVVAIKKK KKKSGGAAPE AAAAVVGCCL SSSSSAIFRR HPPEEEN--- ---KVVTTTA SLLVVAIKKK KKKENNAAPD ---------- ---------- ---------- ---------- ---------- ---------- GGGGVVGCCF XXXXXXXXXX X--------- ---------- ---------Q QQQENNEEEM GGGGVVGCCL AAAAAKVFHH KKKSSSS--- ---EEEKKKK VIIDDIGVVD DDDGSSVVED ---------- ---------- ---------- ---------- ---------- ---------- AAAASSTTTL SSSSSQLWLL YEEDDDG--- ---------- ------WKKA AAAADDGGPA CCCCTTSTTL SSSSSQLWLL YEEGGGG--- ---------- ------WKKA AAAADDGGPA ATTTDIIISL LLDDDKFYYS SGGIEEVVDD ISSNNPFKKV LKKVGFHHAA ADDP------ MTTTDIIISL LLDDDRFYYS SGGLEELLDD ITTNNPHQQR LRRVGYHHEE EPPP------ ATTTDLLLSL LLDDDRFYYS SGGTEEMMDD VSSDDPHNNV LSSVGARRAA APPP------ ATTTDLLLSM MMDDDRFYYS SGGTEEMMDD VSSDDPRKKK LSSVGARRTT TPPP------ ATTTDLLLSL LLDDDKYYYA AGGLEEMMDD VSSDDPMNNV LKKVGVKKTT TPPP------ ATTTDLLLSM MMDDDRFYYS SGGTDDLLDD VSSDDPFEEK LKKVGVSSAA ATTP------ ATTTDLLLSV VVDDDRFYYS SGGTEELLDD VSSDDPFNNR LKKVGVRRAA AGGP------ ATTTDLLLSL LLDDDRFYYS SGGTEELLDD VSSDDPFNNR HSSVGVRRAA AAAP------ ETTTDLLLSL LLDDDRFYYS SLLHDDIIDD ISSNNPQKKR LQQIGIVVGG GGGVVVLL-Q ETTTDLLLSL LLDDDRFYYS SLLHDDIIDD ISSNNPKKKR LQQIGIVVGG GGGVVVLL-Q ETTTDLLLSL LLDDDRFYYS SLLHDDLLDD ISSDDPQRRR LQQLGIVVGG GGGVVVLL-Q ETTTDLLLSL LLDDDHFYYS SLLHDDIIDD VSSDDPQRRR LQQLGIVVDD DGGVVVLL-Q ETTTDLLLSL LLDDDRFYYS SLLHDDLLDD ISSDDPQRRR LQQLGIVVGG GGGVVVLL-Q ETTTDLLLSL LLDDDRFYYS SLLHDDLLDD ISSDDPQRRR L--------- ---------- ETTT------ ---------- ---------- ---------- ---------- ---------- ETTTDLLLSL LLDDDRFYYS SLLHDDLLDD ISSDDPQRRR LQQLGIVVGG GGGVVVLL-E ETTTDLLLSL LLDDDRFYYN NLLHDDMMDD ISSDDPKRRR LQQIGIVVGG GGGVVVLL-Q ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SPPPPIIIFF FFDDDLLIIL L--------- ---------- ---------- ---------- ETTTDIIISL LLDDDRFYYS SLLHDDIIDD ITTDDPRNNK LQQIGILLGG GGGVVVLL-K ETTTDIIISL LLDDDRFYYS SLLHDDIIDD ITTDDTRNNK LQQIGIQQGG GGGVVVLL-K ETTTDIIISL LLDDDRFYYV VLLHDDIINN IEEDDLKNNV LQQLGIQQGG GSSVAAII-D ETTTDIIISL LLDDDRFYYV VLLHDDIINN IEEDDVKNNK LQQVGIQQGG GSSVAAVV-D ETTTDIIISL LLDDDRFYYV VLLHDDIINN IEEDDPKNNV LQQIGLQQGG GSSVAAVV-D ETTTDIIISL LLDDDRFYYV VLLHDDIINN IEEDDPKNNV LQQIGLQQGG GSSVAAVV-D ETTTDIIISL LLDDDRYYYV VLLHDDIINN IEEDDPAKKV LQQVGLQQGG GSSVYYVV-D ETTTDIIISM MMDDDRFYYS SLLHDDIIDD ISSDDPLKKK LQQVGVHHEE ESSVVVLL-E DTTTDIIISM MMDDDRFYYS SLLHDDIIDD ISSDDPKNNK LQQVGIHHEE ETTVVVLL-D ---------- ---------- ---------- ---------- ---------- ---------- MTTTDIIISL LLDDDRYYYS SRRHDDVVDD ISSDDRANNR LQQVGIQQDD DAARVVLL-P DSSSDIIISL LLDDDRFYYN NRRHDDVVDD ITTDDPENNK LQQLGICCDD DLLNIIVVEK ---------- ---------- ---------- ---------- ---------- ---------- AVVVDIIIAA AADDDQTWWN NMMDKKTTDD ISSDDPHKKF QEEKRVNN-- ---------- AVVVDIIISN NNDDDSRWWN NMMDKKTTDD ISSDDPHHHR QEEKAVNN-- ---------- ----AAGGHH KKKTTGAPPQ MLEEISRRDD GGGGVYYYYV NSLYYSTTWD NQFFFFYEWW ----SSGGAA EEETTGAPPQ MISSVSRRDD GGGGVYYYYI NSLYYSSSWN NQFFFFY-WW ----NNGGRR TTTAAGGPPQ MVEEISRRDD GGGGVYYYYW NSLYYSTTWD DQFFFFYDAA ----NNGGKK AAAAAAGPPQ MVEEISRRDD GGGGVYYYYW NSLYYSTTWD DQFFFFYDVV ----NNGGKK TTTGGYGPPQ MVEEISRRDD GGGGVYYYYW NSLYYSTTWD EQFFFFYGAA ----KKNNGG AAANNGGPPQ MVEEISRRDD GGGGVYYYYF NSLYYGAAVD PQFFFFYEWW ----TTSSAA EEENNGGPPQ MVEEISRRDD GGGGVYYYYF NSLYYRAAWD EQFFFFYDWW ----AASSGG PPPNNGGPPQ MVEEVSRRDD GGGGVYYYYF NSLYYASSWD EQFFFFYVWW EPLVKKGGKK RRRPPGGPPQ MIQQLSLLDD GGGGLYYYYA TSLYYSDDWD KQFFFFYPEE EPLVKKGGKK RRRPPGGPPQ MIQQLSLLDD GGGGLYYYYV TSLYYSAAWD KQFFFFYPEE EPLVKKGGKK KKKPPGGPPQ MIQQLSLLDD GGGGLYYYYV TSLYYSAAWD KQFFFFYPEE EPLVKKGGKK QQQAAGGPPQ MIQQLSLLDD GGGGLYYYYV TSLYYSAAWD KQFFFFYPEE EPLVKKGGKK RRRAAGGPPQ MIQQLSLLDD GGGGLYYYYI TSLYYSAAWD KQFFFFYPEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EPLVKKGGKK RRRAAGGPPQ MIQQLSLLDD GGGGLYYYYI TSLYYSAAWD KQFFFFYPEE EPLVKKGGKK RRRPPGGPPQ MIQQLSLLDD GGGGIYYYYV TSLYYSDDWD KQFFFFYPEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DPVIKKGGKK KKKPPGGPPQ MIQQLSLLDD GGGGLYYYYV NSLYYSKKWD KQFFFFYPEE EPVTKKGGKK IIIPPGGPPQ MIQQLSLLDD GGGGIYYYYV SSLYYSIIWD KQFFFFYPEE GSPEQQGGQQ KKKRRGGPPQ MIQQLTLLDD GGGGLYYYYV NSLFFSAAWD KQFFFFYPKK GSPEQQGGKK KKKRRGGPPQ MIQQLSLLDD GGGGLYYYYV NSLFFSAAWD KQFFFFYPQQ GFPQKKGGKK SSSRRGGPPQ MIQQLSLLDD GGGGLYYYYA NSLFFSAAWD RQFFFFYPKK GFPQKKGGKK SSSRRGGPPQ MIQQLSLLDD GGGGLYYYYA NSLFFSAAWV VSFFFFYPKK DYPQKKGGHH RRRRRGGPPQ MIQQLSLLDD GGGGIYYYYV NSLFFSRRWD EQFFFFYQKK KILYKKGGRR KKKEEGGPPQ MLQQLSLLDD GGGGLYYYYV TSLYYKKKWD DQFFFFYPSS HILYKKGGRR QQQEEGGPPQ MLQQLSLLDD GGGGLYYYYV TSLYYKKKWD DQFFFFYPSS ---------- -----GGPPA KIQQLSVVDD GGGGLYYYYV NSFYYSTTWD KQFFFFYPEE EPVFKKGGRR RRRLLGGPPQ MLQQLSLLDD GGGGLYYYYV SSLFFSPPWD KQFFFFYPAA EPRYKKGGRR RRREEGGPPQ MLQQLSLLDD GGGGLYYYYV SSLYYSPPWD KQFFFFYPQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MVSSQSWWDD GGGGVYYYYF SSLLLANNWD --------KK ---------- ---------- MVSSSSWWDD GGGGLYYYYY SSLLLANNWD --------KK MVKLNAANN- --PSSGLEEI IDEFVVDDGE ----ASSHHQ LSSSGASSDD DSYCYYP--- MAKVNVVNN- --PEEGLEEL LEEFVVDDGR ----AAAHHQ LWWWGASTDD DSFCYYP--- QVLAHAAGG- --PDDGLTTL LADWVVEEPD G---YAAHHQ LEEEGCSTDD DSFCYYPVVK EVMANVVGG- --GNNGLEEL LDDFVVSSPD G---YAAHHQ LEEEGCSTDD DSFCYYPVV- MVMANVVGG- --ENNGLTTL LDDWVVDDPA G---YSSHHQ LEEEGCSTDD DSFCYYPVV- MVKLDAAGG- --PNNGIEEF FDKFLLEEPK G---HPPHHQ LQQQGCSSDD DSYCYYP--- MVKVDVVNN- --PDDGMQQF FDNFVVDDGE ----QVVHHQ LQQQGASSDD DSYCFFP--- IAKAEAADD- --PGGGLSSL LDGFTTEEGD G---LPPHHQ LEEEGSSSDD DSYCYYP--- GSVMLQQVVD TTVNNGLKKL LNNLVVDDGK EGGPAAAHHE YPPPGCSSDD DIWI------ GSVMLQQIID TTANNGLKKL LNNLVVDDGK EGGPAAAHHE YPPPGCSSDD DIWI------ GSVMLQQIID TTVKKGLKKL LNNLVVDDGK EGGPAAAHHE YPPPGCSSDD DIWL------ GSVMLQQIID TTVKKGLTTL LNNLVVDDGK EGGPAAAHHE YPPPGCSSDD DIWL------ GSVMLQQVVD TTVKKGLKKL LNNLVVDDGK EGGPAAAHHE YPPPGCSSDD DIWI------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSVMLQQVVD TTVKKGLKKL LNNLVVDDGK EGGPAAAHHE YPPPGCSSDD DIWI------ GSVMLQQIID TTVKKGLKKL LNNLVVDDGK EGGPAAAHHE YPPPGCTSDD DIWL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSVMLQQIID TTEKKGLKKL LNNLVVDDGK EGGPVAAHHE YPPPGCSSDD DIWV------ GAVMLQQIID TTKKKGLKKL LNNLVVDDGK EGGPVAAHHE YPPPGCTSDD DIWI------ GSHILQQIID TTEKKGLKKI INNFVVDDGA EGGPAAAHHE YPPPGCTSDD DIWI------ GSHILQQIID TTENNGLKKI INNFVVDDGA EGGPSAAHHE YPPPGCTSDD DIWI------ GSHIIQQIID TTEKKGLSSI INNFVVDDGD EGGPAAAHHE YPPPGCTSDD DIWI------ GSHIIQQIID TTEKKGLTTI INDFVVDDGD EGGPSAAHHE YPPPGCTSDD DIWI------ GSHMLQQIID TTEKKGLSSI INNFVVDDGA EGGPSAAHHE YPPPGCTSDD DIWI------ GATMVQQVVN PPESSKMEEI INDLIIDDGK IGGPYAAHHE YPPPGCTSDD DIWI------ GATMLQQIID PPITTHMVVI INNLIIDDGK VGGPYAAHHE YPPPGCTSDD DIWI------ GSVMLQQIID TTEKKGLTTV VNNLVVDDGK EGGPCAAHHD FPPPCSTSDD DILA------ GGTIVQQLLD VVENNGMKKL LNNLVVDDGG EGGPGPPHHE ---------- ---------- GGHIVLLIID TTVNNGISSL LNDLVVDDAN EGGPSPPHHE YPPPGCTSDD DIWLAANAA- ---------- ---------- ---------- ---------- ---------- ---------- GKDDAQQYYL YYNWWGKEEL LVDAVVDDYE LGG--AAHHI FGGGSLYSSS S--------- GKDDEQQFFL YYYWWGKEEL LKQAIIDDYA EGG--PPHHQ FGGGALYAGG GPAGDDGRRL ------- ------- KR----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LVQQARE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSSSSAAAAA KKKKPEAATP CRRAAVVLTA ALADDGGAAQ QQLPPTAAQQ LLSSSSLLTT gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPGSPPVVVV AYQQQAAWWT SSSIASSPRS SEEKGGRKRS VGISSSAAAV VVAAKQQQVA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MAAASSAAP LLLLTPTPHP PNNLAAPAPP HRTRLLVVVR RRPPYRRRTP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MIV VFFFKKKRDP FPSMAKKKKP YVACCYGGTT ---------- ---------- --------MA ALLLKKKPDP FPTDARRRRP YVAAAYGGTT ---------- ---------- ---------M MMMMRRRPDP FASLAQQQQP YTLLLSDDFF ---------- ---------- ---------M MMMMRRRPDP FASLAEEEEP YTLLLSDDFF ---------- ---------- ---------M MLLLRRRPDP FPSLAEEEEP FTLMMSDDAA ---------- ---------- --------MA AWWWKKKPDP FPSLAKKKKP YVAMMDEERR ---------- ---------- --------MV VWWWRRRPDP FPSMAKKKKP YVVRRNMMAA ---------- ---------- --------MA AWWWRRRPDP FPSMAQQQQP YVALLDGGRR ---------- ---------- --MMMAATCT T------CGP YTPAM----P YLPCCYNNTT ---------- ---------- ---------- ---------- ---------P YLPCCYNNTT AAAPPGGKGA AAVIIAAALL LGHHHSSTCG G------CGP YSPAM----P YLPCCYNNTT ---------- ---------- ---------- ---------- ----M----P YLPCCYNNTT ---------- ---------- --MMMAATCG G------CGP YTPAM----P YLPCCYNNTT ---EERRAGF FFTQQSAAMR RITTTAATCG G------CGP YTPAM----P YLPCCYNNTT ---------- ---------- --MMMAATCG G------CGP YTPAM----- ---------- ---------- ---------- --MMMAATCG G------CGP YTPAM----P YLPCCYNNTT ---KKEEEGT TTAPPWLLQL LQTTTAATCG G------CGP YTPAM----P YLPCCYNNTT --LGGCCLFQ QQTTTEHHCT TVSSSPPTCG G------CGP YTPAM----P YLPCCYNNTT ---------- ---------- --MMMAATCG G------CGP YTPAM----P YLPCCYNNTT PRPHHSSLLH HHIEEGAAET TANNNGGKCC CTTTAAAKGP YTPAMKKKKP YVTCCYGGTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMACG G------CGP YSPAM----P YLPCCYSSTT ---------- ---AATLLGV VNKKKSS-NG GCCCKKKSGP YSPSM----P YVTAAYGGTT ---------- ---GGTLLAV VSVVVNNNQG GCCCKKKSGP YSPAM----P YVTAAYGGTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------RM MQQQVVVGGP YTPAM----P YVTAAYGGTT ---------- ---------M MANNNGGACC CGGGAAATGP YTPAMKKKKP YVTCCYGGTT ---------- ---------- -SCCCGGLCH H-------GP YSPAI----P FVTAA---NN ---------- ---------- -PCCCPPLCH H-------GP YSPAI----P FVTAA---HH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MES SCCCKKKCGP YTPAVNNNNP YVVCCQNNLL ---------- ---------- ---------- ---------- ----MSSSSP YTVTTQNNLL ---------- ---------- ---------- --------MP LT-ILSSSSD FSNWWHDDII ---RRRREG- --------LA AGLLLAAMLP PRRRAAAFAD TQSMPIIIIG YVWTTGEEGG ---RRFFISP PPSHHFLLLV VGLLLAALAP PGGGVVVRAD TASMKIIIIG YVWTTGEEGG IRRAAADIAV VDNKKSSSEE TYKKKVVHKL LLYNDDELLL HHFWAASSAC C--PPNGG-- VAAPPPDLAV VDDKKSSSPP TYKKKIIYKL LLYGDDELLL HHFWAASSAC C--PPNAA-- -RRPPPDLAV IDKGGSSSSS TYKKKVVHTM MMNGDDEFFF HHFWAASSSS S--PPLTTGG -KKPPPDLAV IDKGGSSSPP TYQQQVVHTM MMNGDDEFFF HHFWAASSAS S--PPLAAGG -KKPPPDLAV VDDTTSSSEE KFQQQVVHQM MMNGDDEFFF HHFWAASSAS S--PPLTTGG -QQPPPDIAV VDDAASSSPP RYSSSVVGQM MMHGDDELLL HHFWAASSCC C--PPNAAPP GKKPPPDMCV VDDQQSSSSS TFQQQVVGVM MMYGGGELLL HHFWAASSMC C--PPNAAPP -RRPPPDLGV LDDDDSSSGG TYQQQVVGRM MMNADDELLL HHFWAASSAC C--PPYAAPP TAAPPPDLAT VDDKKSSSPP QYQQQIIHRM MMYKDDELLL HHSWTTSSC- ------FFGG IAAPPPDLAT VDDKKSSSPP HYQQQIIHRM MMHKDDELLL HHSWTTSSC- ------FFGG IAAPPPDLAT VDDKKSSSPP QYQQQIIHRM MMNRDDELLL HHSWAASSC- ------FFGG IAAPPPDLAT VDDKKSSSPP QYQQQIIHRM MMHKDDELLL HHSWTTSSC- ------YYGG TAAPPPDLAT VDDKKSSSPP QYQQQIIHRM MMNKDDELLL HHSWTTSSC- ------FFGG TAAPPPDLAT VDDKKSSSPP QYQQQIIE-- ---------- ---------- ---------- TAAPPPDLAT VDDKKSSSPP QYQQQIIHRM MMNKDDELLL HHSWTTSSC- ------FFGG TAAPPPDLAT VDDKKSSSPP QYQQQIIHRM MMNKDDELLL HHSWTTSSC- ------FFGG TAAPPPDLAT VDDKKSSSPP QYQQQIIHRM MMYKDDELLL HHSWTTSSC- ------FFGG TAAPPPDLAT VDDKKSSSPP QYQQQIIHRM MMNKDDELLL HHSWTTSSC- ------FFGG TAAPPPDLAT VDDKKSSSPP QYQQQIIHRM MMNKDDELLL HHSWTTSSC- ------FFGG IKKLLLDLAT VDDSSSSSPP TYQQQIIHRV VVHGDDKLLL HHSWSSSSC- ------HHGG ---------- ---------- ---------M MMNNDDELLL HHSWTTSSC- ------YYGG IKKPPPDLAT VDDKKSSSPP SYQQQIIHRM MMNNDDELLL HHSWTTSSC- ------YYGG IKKPPPDLAT VDDSSSSSPP TYKKKIIHRV VVYGDDELLL HHTWSSSSC- ------HHGG IKKPPPDLAT VDDNNSSSPP TYKKKIIHRV VVYGDDELLL HHTWSSSSC- ------HHGG ---------- ---------- ---------M MMFGDDELLL HHSWSSSSC- ------HHGG IKKPPPDLAT VDDSSSSSPP SYSSSIIHRM MMFGDDELLL HHSWSSSSC- ------HHGG IKKPPPDLGT VDDNNSSSPP TYQQQIIHRV VVHGDDELLL HHSWAASSC- ------HHGG AGGPPPDIFT VDNEESSSDD TFQQQIISRV VVHGDDEVVV HHTWAASSC- ------HHDD RGGPPPDIFT VNNEESSSEE TFQQQIISRV VVNGDDEVVV HHTWAASSC- ------HHDD ---------- ---------- ---------- ---------- ---------- ---------- EHHGGGDLAT VDDAASSSPP TYQQQIIHRT TTSHNNELLL HHSWTTSSCF FVVPP-GGGG EHHGGGDLST VDDEESSSPP TYQQQVVHRT TTRGDDELLL HHSWAASSCY YVVDDESSSS QDDIIITRKN PRVQQVVVFF LGSSSLLKDV VVVEDDKEEE LDSPPPIIK- --------GG GEEQQQDLVT IDRGGSSSAA TRQQQIINSV VVGRNNEAAA HHGFAA---- ---------- GEEQQQDLVT VDNKKSSSPP QYKKKVVNTV VVGRNNEAAA HHSFDD---- ---------- -NNNNNIEER FLLIIIPGGG GLRRSSSRII ITPPNPPPEP PIIKEEPPPE EKSYLTTCGG -FFFFFLEER YLLIIIPAAA ALRRSSSRII VTPPDKKKRP PVAKEEPPPE EGTYYTTCGG GFFFFFLEER FLLIIIPGGG GLRRSSSRIV ITPPHPPPQA AIHKEEPPPD DATYPTTCGG GFFFFFIEER YLLIIIPGGG GLRRSSSRII ITPPDPPPKA AIHKEEPPPE EKTYPTTCGG GFFFFFLEER YLLIIIPGGG GIRRSSSRII VV--EPPPKA AIHKEEPPPE EATYPTTCGG PHHHHHMEER YLLVVVPGGG GLRRSSSRII LTPPDPPPKP PLAKEEPPPE EETYPTTCGG PHHHHHVEER YLLVVVPDDD DIRRSSSHII LTPPDPPPQP PVVKDDPPPN NETYPTTCGG PHHHHHVEER YLLIIIPGGG GIRRSSSRII VTPPDPPPEP PIVKEEPPPE ERTYPTTCGG GTTTTTKSSN KLLIIIPGGG GLMMSSSRIV VVSSEPPPAP PLHKEEAAAS SACVTTTCLL GTTTTTKSSD KLLIIIPSSS SIIISSSRIV VVSSEPPPAP PLHKEEPPPN NACLLTTCLL GTTTTTKSST KLLMMMPCCC CLMMSSSRIV VVSSDPPPAP PLHKEEAAAE EACLVTTCLL GTTTTTKAAT KLLVVVPAAA ALIISSSRIV VVTTEPPPAP PLHKEEPPPK KTCLFTTCLL GTTTTTKSST KLLVVVPSSS SLIISSSRIV VVSSEPPPAP PLHKEEPPPE EACLLTTCLL ---------- ---------- ---------- ---------- ------PPPK KACLLTTCLL GTTTTTKSST KLLVVVPSSS SLIISSSRIV VVSSEPPPAP PLHKEEPPPK KACLLTTCLL GTTTTTKSST KLLVVVPSSS SLIISSSRIV VVSSEPPPAP PLHKEEPPPK KACLLTTCLL GTTTTTKSSN KLLVVVPSSS SFIISSSRIV VVTTEPPPAP PLHKEEAAAK KECLPTTCLL GTTTTTKSST KLLVVVPSSS SL-------- ---------- ---------- ---------- GTTTTTKSST KLLVVVPSSS SLIISSSRIV VVSSEPPPAP PLHKEEPPPK KACLLTTCLL GSSSSSAKKR FLLIIIPSSS SLLLSGGRVV VTTTDPPPTP PLHKEESSSE EEILPTTCLL GSSSSSKVVN KLLIIIPCCC CLIISSSRIV VVTTDPPPAP PIHKEEPPPY YWCLLTTCLL GSSSSSKVVN KLLIIIPCCC CLIISSSRIV VVSSDPPPAP PIHKEEPPPY YWCLPTTCLL GSSSSSAEER FLLIIIPSSS SLVVSGGRIV ITTTNPPPSP PLHKDDPPPA AQTLPTTCLL GSSSSSAQQR FLLIIIPGGG GIVVSGGRVV ITTTNPPPAP PLHKEEPPPE ETTLPTTCLL GSSSSSADDR YLLVVVPSSS SLIISGGRIA ITEENPPPAP PLYKDDPPPK KETLPTTCLL GSSSSSVDDR YLLVVVPSSS SLIISGGRIA ITEENPPPAP PLYKDDPPPK KDTLPTTCRR GSSSSSASSR FLLIIIPSSS SLLLSGGRVV VTKKDPPPAP PLHKEEAAAE EETLPTTCLL DTTTTTEKKS HLLIIIPCCC CLNNSDDRII IVNNE---KI ILEHEEPPPS SSNLPTTCLL DTTTTTEKKS HLLIIIPCCC CLNNSDDRIV IVNNE---EI ILQHEEPPPS SANLPTTCLL ---------- -MMVVVRKKK KLSSSGGVEK VVGG------ ---------- ---------- GVVVVVPTTD RLLVVVPCCC CLNNSDDRIV ITTTDPPPAP PLAKEEGGG- -KACPTTCLL SVVVVVPKKD RLLVVVPSSS SLNNSDDFII LVTTDPPPKP PIVKDDGGG- -KHVPTTCLL GVVVVVQGGP QMMLLLLSSS SLDDGKKRLV TSYYSAAADK KFYP------ -KLLSTTYQQ -------DDR FFFWWWGGGG GLDDTNNRII FVSSDPPPNP PLHKDDTTT- -DGVPTTALL -------DDR YLLWWWGGGG GLDDTSSKIV FVSSDPPPRP PLSKTTDDD- -KGVPTTALL DIISALNEE- GEPGIIMLLD YYSSSEEEPP PPPGGKEDDG GGDYYY---- -----LLYYD DIISALGPP- GEPGIILLLD DDTTTEEEPP PPPGGREYYG GGPYYY---- -----FFYYD EVVSTLGAAK GDAGIIIMMD EETTTDDDVV VVVGGREDDG GGPDDD---- -----KKYYD DVVSTLGGGK GNPGVVIMMD EETTTEEEVV VVVGGREDDG GGPTTT---- -----LLYYD EVVSTLGGGE GDPGIIILLD EETTTEEEII IIIGGREDDG GGETTT---- -----KKYYD GVVTALNAA- GKPGIIMLLD QQSSSEEEPP PPPGGREEEG GGPYYY---- -----FFYYD DIISALSPP- GEPGIIILLD DDNNNEEEVV VVVGGREDDG GGDYYY---- -----LLYYD DVVSALSPP- GDPGVVVMMD EESSSDDDPP PPPGGREEEG GGPQQQ---- -----LLYYD SMMVNTGDD- QNKSFFLLLD EETTTEEEVV VVVGGTEPPG GGAPPP---- -----MMYYD SMMISSGDD- QNKGFFLLLD EETTTEEEVV VVVGGTEPPG GGEPPP---- -----MMYYD SMMISTGDD- KNKGFFLLLD EETTTEEEVV VVVGGTEPPG GGAPPP---- -----MMYYD SMMVSTGDD- ENKGFFLLLD KKTTTEEEVV VVVGGTEPPG GGAPPP---- -----LLYYD SMMISSGDD- KNKGFFLLLD EETTTEEEVV VVVGGTEPPG GGAPPP---- -----SSYYD SMMISSGDD- KNKGFFLLLD EETTTEEEVV VVVGGTEPPG GGAPPP---- -----LLYYD SMMISSGDD- KNKGFFLLLD EETTTEEEVV VVVGGTEPPG GGAPPP---- -----LLYYD SMMISSGDD- KNKGFFLLLD EETTTEEEVV VVVGGTEPPG GGAPPP---- -----LLYYD TMMISTGDD- KNKGFFLLLD EETTTEEEVV VVVGGTEPPG GGSPPP---- -----MMYYD ---------- ---------- ---------- ---------- ---------- ---------- SMMISSGDD- KNKGSSVLLL --RRREEECC CCCGG----- ---------- ---------- SMMISCGDD- ENANGGLLLL SSEEENNNVV VVVGGRSRRF FFPSSS---- -----KKRRT CMMISSGDD- YNKGFFLLLD EETTTEEEVV VVVGGNEEEE EEAPPP---- -----FFYYD CMMISSGDD- CNKGFFLLLD EETTTEEEVV VVVGGNEEEE EESQQQ---- -----FFYYD SMMISCGDD- DNENGGLLLL SSDDDNNNVV VVVGGREPPH HHSLLL---- -----FFYYD SMMISCGDD- DNENGGLLLL SSEEENNNVV VVVGGREPPH HHSLLL---- -----FFYYD SLLVSCGDD- ENKNGGLLLL SSDDDNNNII IIINNREPPH HHSLLL---- -----FFYYD -LLVSCGDD- ENKNGGLLLL SSDDDNNNII IIINNREPPI IISLLL---- -----YYYYH SMMISCGDD- ENANGGLLLL SSEEENNNVV VVVGGREPPH HHSLLL---- -----FFYYD DMMISTGEE- NTSNFFLLLD KKTTTEEEPP PPPGGTPDDK KKTPPP---- -----FFYYD DMMISTGEE- DSSNFFLLLD KKTTTEEEPP PPPGGTPDDK KKVPPP---- -----FFYYD ---------- ---------- ---------- ---------- ---------- ---------- NMMISIGDD- ENK-DDVEEF KKNNNEEELL LLLGGTSGGR RRKLLL---- -----CCYYD NMMISVGDD- EYK-DDILLF SSDDDNNNCC CCCGGTTGGK KKKLLL---- -----CCYYD NKKQDGNEE- LVVNGGQTTS HHEEEGGGLL LLLAAKESSF FFEIII---- -----LLLLS GIITGLNDD- DGRALLEYYN DDGGGYYYVV VVVTTYMTTD DDDQQQVAVV AAADDYYYYD GIITGLNNN- DGRALLEYYT AAGGGYYYVV VVVTTHITTG GGDRRRIKYY AAADDYYYYD FWWWNN-NNL SSW--IIIIE LKKLLHHKKK KDD-GNNRRF DLLRKKKKKK IHSLTTTTTG FWWWNN-SSM TSW--FFFFE FSSLLCCKKK KEEGGNNKKV DLLAKRRRRR LYAIDDDDDG FWWWNN-RRM SSW--FFFFE IVVPPDDLLL LAANGHHRRF DLLRARRRRR VQTIDDDDDG FWWWNN-RRM TSW--FFFFE IVVPPDDLLL LSSNGHHRRF DLLRARRRRR VQTIDDDDDG FWWWNN-RRM SSW--FFFFE IVVPPDDLLL LSSNGHHKKF KLLRDKKKKK VQTIDDDDDG GWWWHH-YYL TSW--VVVVE LVVPPIILLL LGGAGRRRRF DLLTRRRRRR LQEIDDDDDG FWWWHH-YYL TSW--VVVVE VLLGGEELLL LAAGGHHRRV DLLYRRRRRR LQTLDDDDDG FWWWHH-YYM TSW--IIIIE LDDPPIILLL LNNKGRRRRI DLLRRRRRRR LQALDDDDDG FYYYQQ-HHM STW--FFFFK NPPAAVVAAA A--GGSSRRV DWWQREEEEE IQTLQQQQQT FYYYQQ-HHM STW--FFFFK NPPAAVVAAA A--GGSSHHV DWWQREEEEE IQTLQQQQQK FYYYQQ-HHM STW--FFFFR NPPAAVVAAA A--GGSSHHV DWWQREEEEE IQTLTTTTTQ FYYYQQ-HHM STW--LLLLR NPPAAVVAAA A--GGSSHHV DWWQREEEEE VQTLPPPPPQ FYYYQQ-HHM STW--LLLLR NPPAAVVAAA A--GGSSHHV DWWQHEEEEE VQTLSSSSSK FYYYQQ-HHM STW--LLLLR NPPAAVVAAA A--GGSSHHV DWWQREEEEE VQTLSSSSSK FYYYQQ-HHM STW--LLLLR NPPAAVVAAA A--GGSSHHV DWWQREEEEE VQTLSSSSSK FYYYQQ-HHM STW--LLLLR NPPAAVVAAA A--GGSSHHV DWWQREEEEE VQTLSSSSSK FYYYQQ-HHM STW--VVVVQ NPPAAVVAAA A--GGKKHHV DWWQREEEEE VQTLLLLLLP ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AS--RRRRL RDDYYAAAAA A--SAGGII- ---------- ---------- HYYYEEYWWF SWQ--YYYYT ELLMMLLAAA A--SHVVIIL NYYIMVVVVV DESLPPPPPQ FYYYQQ-HHM STW--FFFFA KMMEEVVAAA A--GGHHSSV DWWTERRRRR IQTIDDDDDG FYYYQQ-HHM STW--FFFFA KMMEEVVAAA A--GGHHSSV DWWTERRRRR VQTIDDDDDG FYYYQQ-HHM STW--FFFFT DLLQQVVDDD D--GGRRHHC QLLAREEEEE RQTLDDDDDG FYYYQQ-HHM STW--FFFFL NLLQQVVDDD D--GGRRHHV SWWPGEEEEE KQTLDDDDDG FYYYQQ-HHM STW--FFFFS DLLQQVVDDD D--GGSSHHV SWWPGEEEEE KQLIDDDDDG FYYYQQ-HHM STW--FFFFS NLLQQVVDDD D--GGSSHHV SWWPGEEEEE KQLIDDDDDG YYYYQQ-HHM SSW--FFFFR DLLQQVVDDD D--GGRRHHV DWWPGEEEEE KQTLDDDDDG FYYYQQ-RRM STW--IIIIK NPPAAVVEEE E--GGNNSSI EWWDSKKKKK LQTIDDDDDP FYYYQQ-RRM STW--IIIIK NPPAAVVEEE E--GGNNSSI EWWDTKKKKK LQTIDDDDDP ---------- SIR--VVVVC ELLKKQQEEE E--PIKKCCV ---------- ---------- YYYYQQ-FFM ASW--FFFFR HPPTTCCDDD DRRTGCCRRF RWWQEEEEEE FQTIDDDDDG FYYYQQ-FFM SSW--WWWWR KNNVVLLDDD DMMSGCCRRF KWWSTTTTTT YQTIDDDDDG NNNNNN-RRS SDP--AAAAF ESSFFKKTTT TGGPPQQHHE L--------- ---------- IAAALL-KKM TSFNNMMMMD MLLQQAAAAA AMMKGNNTTQ DLLHTQQQQQ KKVFNNNNNP VAAALL-KKL TSFNNMMMMD MLLAAPPAAA AMMKGNNTTT DLLHTQQQQQ KKVFDDDDDP ENRMM----- PLPTKLFIIM VVSDSSSSSI WL---EDGGK WWWNNNKKIE IPEEPLLGPE QHRMM----- PLPTKLFVVV VLNDSSSSSI WL---EDGGK WWWQQQRRID IEQQPFFGPP AHQMM----- PAPVREFVVV VVDNEESSSI WT---EGGGK FFFHHHKKAT IPEEPAAAPP AHQMM----- PAPVREFVVV VVDNEESSSI WT---EGGGK FFFHHHKKAT IPEEPAAKPP AHQMM----- PAPSKDFCCV VVDNQQAAAI FTKKKDDGGT FFFEEEKKIT IDVVPAAAPD DHQLL----- PAPTKAFVVC VISDSSSSSI WT---DKDDK WWWAAAKKIE IPEEAAAPPP AYQMM----- PAPTKAFMMC VVSDSSSSSI WL---DNGGS WWWHHHKKID IPEEPAAEPP EHQMM----- PAPARTFVVV VVSDSSSSSV WL---QNGGS WWWGGGKKIE IPEEPAAPPP -DGLL----L FLPSATFVVC ALSIRRYYYK NE-------- --------TW SVKKVIIVKV -DGLL----L FLPDATFVVC ALSIRRYYYK NE-------- --------TW SVKKVIIVKV -DGLL----L FLPDAAFVVC ALSIRRYYYK NQ-------- --------TW SVKKVIIVKV -DGLL----L FLPDAAFVVC ALSIRRFFFK NE-------- --------TW SAKKVIIVKV -DGLL----L FLPDAAFVVC ALSIRRYYYK NE-------- --------TW SVKKVIIVKV -DGLL----L FLPDAAFVVC ALSIRRYYYK NE-------- --------TW SVKKVIIVKV -DGLL----L FLPDAAFVVC ALSIRRYYYK NE-------- --------TW SVKKVIIVKV -DGLL----L FLPDAAFVVC ALSIRRYYYK NE-------- --------TW SVKKVIIVKV -DGHH----L FLPAASFVVC ALSIRRYYYK NE-------- --------TW SVKKVIIVKV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -DQAANNPPL SIKNINYDDV EVSGGGSSSD PD-------- --------AV VLRRKLLLVV EDGLL----L FLPDAALVVC ALSVRRYYYK EK-------- --------KW AAKKVIIVKV KDGLL----L FLPDADLVVC ALSIRRYYYK EK-------- --------KW AAKKVIIVKV NTGLL----L FLPAKDFVVS ALSMRRFFFK TQ-------- --------SW SHLLAIIVKV DKGLL----L FLPAKDFVVS ALTMRRFFFK TQ-------- --------SW NHIIVIIVKV ETGLL----L FLPSKDYVVS ALSMRRFFFK NS-------- --------TW SYIIVIIVKV PTGLL----L FLPSKDFVVS ALSMRRFFFK NS-------- --------TW SHVVVIIVKV STGLL----L FLPSKDYVVC ALTMRRFFFK TA-------- --------SW SHVVAIIIKV QLGAA----L FLPTSEFVVC ALGIRRHHHP VE-------- ------TTTH AALLVAAIKV MRGAA----L FLPTSEFVVC ALGIRRHHHP DE-------- ------KKVQ TALLVAAIKV ---------- ---------- ---------- ---------- ---------- ---------- DDGLL----L FLPRENYVVC AFXXXXXXX- ---------- ---------- --------QG SDGII----L FLPKKAFVVC ALNVHHKKKK KS-------- ------EEEA KKIIDIIGDT ---------- ---------- ---------- ---------- ---------- ---------- GP-------L FPSNANFSST ALTLLLYYYE DD-------- ---------- -------WAV GP-------L CAEAHNFTTT ALTLLLYYYE DG-------- ---------- -------WAV LLKKPKKVPP LVDIISSSLD DDDFLYWGII GGEVRRRQYY DSSSSPPPPV LLTTGGKKGI LLKKDKKVPP LVDIISSSLD DDDFLYWGLL GGELRRRQYY DTTTTPPPPR LLAAGGKKGL LLQQGGGVPP LVDILSSSLD DDDFLYWGTT GGEMRRRQYY DSSSSPPPPV LLAAGGRRGI LLQQGGGVPP LVDILSSSMD DDDFLYWGTT GGEMRRRQYY DSSSSPPPPK LLAAGGHHGI LLKKGGGCPP LVDILSSSLD DDDYLYWGLL GGEMHHHQYY DSSSSPPPPV LLTTGGEEGI LLKKGKKVPP LVDILSSSMD DDDFLYWGTT GGDLLLLQYY DSSSSPPPPK LLTTGGRRGI LLKKPKKVPP LVDILSSSVD DDDFLYWGTT GGELHHHQYY DSSSSPPPPR LLTTGGQQGI LLKKDGGVPP LVDILSSSLD DDDFLYWGTT GGELRRRQYY DSSSSPPPPR HHTTGGRRGI GGWWMPPMPP LIDILSSSLD DDDFLYWLHH GGDIRRRQYY DSSSSPPPPR LLTTGGFFGS GGWWMPPMPP LIDILSSSLD DDDFLYWLHH GGDIRRRQYY DSSSSPPPPR LLTTGGFFGS GGWWMPPMPP LIDILSSSLD DDDFLYWLHH GGDLRRRQYY DSSSSPPPPR LLTTGGFFGS GGWWMPPMPP LIDILSSSLD DDDFLYWLHH GGDIRRRQYY DSSSSPPPPR LLTTGGFFGS GGWWLPPMPP LIDILSSSLD DDDFLYWLHH GGDLRRRQYY DSSSSPPPPR LLTTGGFFGS GGWWLPPMPP LIDILSSSLD DDDFLYWLHH GGDLRRRQYY DSSSSPPPPR LL-------- GGWWLPPMPP LI-------- ---------- ---------- ---------- ---------- GGWWLPPMPP LIDILSSSLD DDDFLYWLHH GGDLRRRQYY DSSSSPPPPR LLTTGGFFGS GGWWMPPMPP LIDILSSSLD DDDFLYWLHH GGDMRRRQYY DSSSSPPPPR LLVVGGFFGS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKFFGVVLSS EFPAIFFFFS SSDLII---- ---------- ---------- ---------- GGWWAPPMPP LIDIISSSLD DDDFLYWLHH GGDIRRRQYY DTTTTPPPPK LLVVGGFFGS GGWWPPPMPP LIDIISSSLD DDDFLYWLHH GGDIRRRQYY DTTTTTTTPK LLVVGGFFGS NNWWIPPMPP LIDFISSSLD DDDFLYWLHH GGDIRRRQYY NEEEELLLPV LLTTGGWWGL NNWWFPPMPP LIDFISSSLD DDDFLYWLHH GGDIRRRQYY NEEEEVVVPK LLTTGGWWGL NNWWIPPMPP LIDFISSSLD DDDFLYWLHH GGDIRRRQYY NEEEEPPPPV LLTTGGWWGL NNWWIPPMPP LIDFISSSLD DDDFIYWLHH GGDIRRRQYY NEEEEPPPPV LLTTGGWWGL NNWWIPPMPP LIDFISSSLD DDDYLYWLHH GGDIRRRQYY NEEEEPPPPV LLAAGGWWGL GGWWAPPMPP LIDIISSSMD DDDFLYWLHH GGDIRRRQYY DSSSSPPPVK LLNNSSYYGS NNWWAPPMPP LIDIISSSMD DDDFLYWLHH GGDIRRRQYY DSSSSPPPPK LLNNSSFFGS ---------- ---------- ---------- ---------- ---------- ---------- NNGGEEEMGG MMDIISSSLD DDDYLYWRHH GGDVRRRQYY DSSSSRRRPR LLTTGGFFGA SSGGVEEMGG MIDIISSSLD DDDFLYWRHH GGDVRRRQYY DTTTTPPPPK LLTTGGFFGA ---------- ---------- ---------- ---------- ---------- ---------- DDIIGPPDII LPDIIAAAAD DDDTLWFMDD GGKTRRRLFF DSSSSPPPPF QQIIYYVVRQ DDIIGPPKVV LPDIISSSND DDDRLWFMDD GGKTRRRLFF DSSSSPPPPR QQVVYYTTAQ HRRAAHHP-- ---------- ---------- -AAAKTGGGA LLESSGRRRR VTNNYSSTDD HRREEHHP-- ---------- ---------- -SSSETGGGA IISSSGRRRR VTNNYSSSNN RRRAAHHP-- ---------- ---------- -NNNTAGGGG VVESSGRRRR VTNNYSSTDD RRRTTHHP-- ---------- ---------- -NNNAAAAAG VVESSGRRRR VTNNYSSTDD KKKTTHHP-- ---------- ---------- -NNNTGYYYG VVESSGKRRR VTNNYSSTDD SRRAAHHP-- ---------- ---------- AKKKANGGGG VVESSGRRRR VTNNYGGADD RRRAAHHP-- ---------- ---------- ATTTENGGGG VVESSGRRRR VTNNYRRADD RKKAAHHP-- ---------- ---------- -AAAPNGGGG VVESSGRRRR VSNNYAASDD VRRGGSSVLL E--DDQEEEL TCCQPPEELV VKKKRPGGGG IIQSSGKRRR LTTTYSSDDD VKKGGSSVLL E--DDQEEEL TCCQPPEELV VKKKRPGGGG IIQSSGKRRR LTTTYSSADD VKKGGPPVLL E--DDQEEEL KSSQPPEELV VKKKKPGGGG IIQSSGKRRR LTTTYSSADD VKKDDPPVLL D--DDQEEEL DSSQPPEELV VKKKQAGGGG IIQSSGKRRR LTTTYSSADD VKKGGPPVLL E--DDQEEEL KSSQPPEELV VKKKRAGGGG IIQSSGKRRR LTTTYSSADD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VKKGGPPVLL E--DDEEEEL KSSQPPEELV VKKKRAGGGG IIQSSGKRRR LTTTYSSADD VKKGGPPVLL E--DDQEEEL KSSQPPEELV VKKKRPGGGG IIQSSGKRRR ITTTYSSDDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LRRGGPPVLL E--DDKDDDL ECCQPPDDVI VKKKKPGGGG IIQSSGKRRR LTNNYSSKDD QRRGGPPVLL E--DDKEEEL ECCQPPDDVT VKKKIPGGGG IIQSSGKRRR ITSSYSSIDD QKKGGPPVII G--EEDGGGK TWWQSSDDPE IQQQKRGGGG IIQTTGKRRR LTNNFSSADD QKKGGPPVVV K--DDDGGGE TWWQSSDDPE IQQQKRGGGG IIQSSGKRRR LTNNFSSADD QKKGGPPVVV G--EEDGGGN SFFQFFDDPQ IKKKSRGGGG IIQSSGKRRR LTNNFSSADD QKKGGPPVVV G--EEDGGGN TFFQFFEEPQ IKKKSRGGGG IIQSSGKRRR LTNNFSSAVV QKKGGEEVVV T--EEDDDDK EEEQYYSSPQ VKKKRRGGGG IIQSSGKRRR ITNNFSSRDD HTTEENNVLL E--GGEKKK- ---PIIEELY VKKKKEGGGG LLQSSGKRRR LTTTYKKKDD HSSEETTVLL E--EEDHHHD ---EIIPPLY VKKKQEGGGG LLQSSGKRRR LSTTYKKKDD ---------- ---------- ---------- ------GGGG IIQSSGKRRR LTNNYSSTDD QRRDDPPRLL N--DDPEEEL KEEAPPEEVF LKKKRLGGGG LLQSSGRRRR LSSSFSSPDD CSSDDPPNVV KEEDDKEEEL KEERPPPPRY VKKKREGGGG LLQSSGKRRR LSSSYSSPDD ---------- ---------- ---------- ---------- ---------- ---------- N--------- ---------- ---------- ---------- VVSSSGKRRR VSSSLAANDD N--------- ---------- ---------- ---------- VVSSSGQRRR LTSSLAANDD YYEELKKKWM MKKLNN---- -SGGEEEEID KKKFFVFGGE -------SSQ VLLLGGDDSS YY--LRRRWM MKKVNN---- -EGGEEEELE KKKFFVFGGR -------AAQ VLLLGGDDST YYDDVPPPAQ QLLAHG---- -DGGTTTTLA DDDYWVFPPD GG-----AAQ ILLLGGDDST YYDDVPPPVE EMMANG---- -NGGEEEELD KKKYFVFPPD GG-----AAQ ILLLGGDDST YYGGRGGGAM MMMANG---- -NGGTTTTLD KKKFWVFPPA GG-----SSQ ILLLGGDDST YYEEIDDDWM MKKLDG---- -NGGEEEEFD PPPFFLWPPK GG-----PPQ VLLLGGDDSS YYDDIKKKWM MKKVDN---- -DGGQQQQFD PPPFFVFGGE -------VVQ ILLLGGDDSS YYVVIRRRWI IKKAED---- -GGGSSSSLD PPPFFTVGGD GG-----PPQ ILLLGGDDSS YYPPLIIIEG GVVMLVDVVD TNGGKKKKLN PPPFLVFGGK EEPPLGPAAE LYYYGGDDSS YYPPLIIIEG GVVMLIDVVD TNGGKKKKLN PPPFLVFGGK EEPPLGPAAE LYYYGGDDSS YYPPLIIIEG GVVMLIDVVD TKGGKKKKLN PPPFLVFGGK EEPPLGPAAE LYYYGGDDSS YYPPLIIIEG GVVMLIDVVD TKGGTTTTLN PPPFLVFGGK EEPPLGPAAE LYYYGGDDSS YYPPLIIIEG GVVMLVDVVD TKGGKKKKLN PPPFLVFGGK EEPPLGPAAE LYYYGGDDSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYPPLIIIEG GVVMLVDVVD TKGGKKKKLN PPPFLVFGGK EEPPLGPAAE LYYYGGDDSS YYPPLIIIEG GVVMLIDVVD TKGGKKKKLN PPPFLVFGGK EEPPLGPAAE IYYYGGDDTS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYPPMIIIEG GVVMLIDVVD TKGGKKKKLN PPPFLVFGGK EEPPGGPAAE LYYYGGDDSS YYPPLLLLEG GVVMLIDVVD TKGGKKKKLN PPPFLVFGGK EEPPDGPAAE IYYYGGDDTS YYPPLVVVKG GHHILIDVVD TKGGKKKKIN PPPFFVFGGA EEPPDGPAAE MYYYGGDDTS YYPPLVVVQG GHHILIDVVD TNGGKKKKIN PPPFFVFGGA EEPPDGPAAE MYYYGGDDTS YYPPLMMMKG GHHIIIDVVD TKGGSSSSIN PPPFFVFGGD EEPPEGPAAE MYYYGGDDTS YYPPIMMMKG GHHIIIDGGD TKGGTTTTIN PPPFFVFGGD EEPPDGPAAE MYYYGGDDTS YYQQLVVVKG GHHMLIDVVD TKGGSSSSIN PPPFFVFGGA EEPPEGPAAE MYYYGGDDTS YYPPHVVVSG GTTMVVNIID PSGKEEEEIN RRRFLIFGGK IIEEGGPAAE MYYYGGDDTS YYPPNVVVSG GTTMLIDVVD PTGHVVVVIN KKKFLIFGGK VVPPGGPAAE MYYYGGDDTS YYPPVVVVEG GVVMLIDVVD TKGGTTTTVN KKKFLVFGGK EEPPNGPAAD IFFFCGDDTS YYPPMVVVAG GTTIVLDIID VNGGKKKKLN EEEFLVFGGG EEPPYGPPPE M--------- YYPPMVVVQG GHHIVIDVVD TNGGSSSSLN EEEFLVFAAN EEPPYGPPPE MYYYGGDDTS ---------- ---------- ---------- ---------- ---------- ---------- --------KG GDDDAYLKKA YWDGEEEELV EEEFAVFYYE LLGGLG-AAI MFFFSSAAYS --------KG GDDDEFLKKL YWDGEEEELK EEEFAIFYYA EEKKLG-PPQ MFFFARAAYA SSYCYP- TSFCYP- TSFCYPV TSFCYPV TSFCYPV SSYCYP- SSYCFP- SSYCYP- SIWI--- SIWI--- SIWL--- SIWL--- SIWI--- ------- ------- SIWI--- SIWL--- ------- ------- ------- SIWV--- SIWI--- SIWI--- SIWI--- SIWI--- SIWI--- SIWI--- SIWI--- SIWI--- SILA--- ------- SIWLANA ------- S------ APAGDGR 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NSAAKAAQQQ PPSSSEATPP CRTTAAAVPP TTTTAAALAG GGMSPRAASL TPPVRKKKAQ gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------A gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AWTTTSSSAA IIQVVLSREE EKGRRKKTSV PGLSSSAVAA AAKPSAAWAA HHPPGGGKGL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AERRRAGL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMGKEEEEGQ ---------- ---------- ---------- ---------- -------LLL KKQGCCCLFN ---------- ---------- ---------- ---------- ---------- ---------- SAPPPLPPPP LLNNNRPHNN NLAPPAASPH PRVRLLVRPP PPYNVPPCPP PPRHSSSLLM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M ---------- ---------- ---------- ---------- ---------- ---------M ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --KRRRREG- ---------- ---------- ---------- ---------- ---------- --KRFFFISM ---------- --MMIIVKKR TSPMMMMMKA PPPPEEELAY VACLYTTGIN NDDFFIVVNP ---------- ----MMAKKP TTPDDMMMRA PPPPEEEIAY VAALYVVGVN NDDFFLVVDP ---------- ------MRRP TSPLLMMMQA PPAAEEEFAY TLLLSPPD-- -DDAALVVKP ---------- ------MRRP TSPLLMMMEA PPAAEEEFAY TLLLSPPD-- -DDAALVVKP ---------- ------MRRP TSALLMMMEG PPVVEEELAF TLMLSPPD-- -DDGGLVVDP ---------- ----MMAKKP SSPLLAAAKA PPPPEEEIAY VAMFDPPE-- -DDAAIVVDP ---------- ----MMVRRP TSPMMVVVKA PPAAEEELAY VVRLNPPMG- -DDAAMVVDS ---------- ----MMARRP TSPMMMMMQA PPRREEELGY VALLDPPG-- -DDAALVLDP ---------- -ATTCCT--C GPLAAKKK-G PPRREEEIVY LPCIYRRNTE EDDYYLTVDP ---------- ---------- -----MMM-G PPRREEEIVY LPCIYRRNIE EDDYYLTVDP LIIAARGPG- -STTCCG--C GPLAAKKK-G PPRREEEIVY LPCIYGGNIE EDDYYLTIDP ---------- ---------- -----KKK-G PPRREEEIIY LPCIYRRNIE EDDYYLTVDP ---------- -ATTCCG--C GPLAAKKK-G PPRREEEIVY LPCIYRRNTE EDDYYLTVDP LQQSSQPPIA AATTCCG--C GPLAAKKK-G PPRREEEIVY LPCIYRRNTE EDDYYLTVDP ---------- -ATTCCG--C GPLAAKKK-G ---------- --------TE EDDYYLTVDP ---------- -ATTCCG--C GPLAAKKK-G PPRREEEIVY LPCIYRRNTE EDDYYLTVDP QPPWWSGWQE EATTCCG--C GPQAAKKK-G PPRREEEIVY LPCIYRRNTE EDDYYLTVDP NTTEETYLVF FPTTCCG--C GPLAAKKK-G PPRREEEIVY LPCIYRRNTE EDDYYLTVDP ---------- -ATTCCG--C GPLAAKKK-G PPRREEEIVY LPCIYRRNTE EDDYYLTVDP MEEGGAVAAA AGKKCCCAAK GPLAAEEEKG PPRREEELVY VTCVYNNGIN NDDYYLTLDP ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MAACCG--C GPLAAKKK-G PPRREEEIVY LPCIYRRSIN NDDYYLTVDP MAATTDHVNE ES--NNGKKS GPISSSSS-G PPRREEELIY VTAVYAAGIE EDDYYLTVDP MGGTTQHVSE ENNNQQGKKS GPLAASSS-G PPRREEELIY VTAVYAAGIE EDDYYLTLDP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RRMVVG GPLAASSS-G PPSSEEELIY VTAVYTTGID DDDYYLTVDP -------AAA AGAACCCAAT GPLAAEEEKG PPRREEELLY VTCVYNNGIN NDDYYLTVDP -------MSP PGLLCCH--- GPAAAKKK-G PPRREEEVLF VTAP----AD DDDAAITVNP -------MP- -PLLCCH--- GPAAAKKK-G PPRREEEVLF VTAP----RD DDDAAITVNP ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMEESKKC GPLAARRRNG PPVVEEELLY VVCVQPPNEE EDDYYLTVDP ---------- ---------- -----RRRSG PPRREEELLY TVTVQPPNEP PDDYYLTVDP ---------- ---------- G--IIIIISL DDDDRRRLYF SNWLHGGDQY YTTDDRNMVG ------AAG- -AMMLLPAAF ESPMMKKKIT GGQQEEEFVY VWTLGVVEGD DDDKKLTLRP MHHFFRASGL LALLAAPVVR ESPMMKKKIT GGQQEEEYVY VWTLGAAEGD DDDKKLTANP PPPKKYYSSK KVELINDLHG WWNAASSSSS SALPPPGPPN NNNIRFLIGL LSRIYIIIDD PPPKKYYGGK KLDLIGDLHG WWNAASSSSS SAYPPPAPPF FFFLRYLIAL LSRIYIVVDD PPPGGYYGGK TVTMTGDFHG WWNAASSSSS SSLPPPTAAF FFFLRFLIGL LSRIYVIIDD PPPGGYYGGQ TVTMKGDFHG WWNAASSSSS SALPPPAAAF FFFIRYLIGL LSRIYIIIDD PPPTTFFGGQ QLIMKGDFHG WWNAASSSSS SALPPPTAAF FFFLRYLIGI ISRIYIVVDD PPPAAYYAAS QVAMAGDLHG WWNAASSSSS SCLPPPAPPH HHHMRYLVGL LSRIYILLDD SSSQQFFGGQ VTDMTGGLHG WWNAASSSSS SMLPPPAPPH HHHVRYLVDI ISHITILLDD PPPDDYYAAQ RVEMAADLHG WWNAAAAAAA AALPPPAPPH HHHVRYLIGI ISRIHIVVDD PPPKKYYSSQ RLPMLKDLHG WWNTTSSSSS SC----FSST TTTKNKLIGL LSRIYVVVDD PPPKKYYSSQ RLPMLKDLHG WWNTTSSSSS SC----FSST TTTKDKLISI ISRIYVVVDD PPPKKYYCCQ RLPMLRDLHG WWNAASSSSS SC----FSST TTTKTKLMCL LSRIYVVVDD PPPKKYYCCQ RLPMLKDLHG WWNTTSSSSS SC----YIIT TTTKTKLVAL LSRIYVVVDD PPPKKYYCCQ RLPMLKDLHG WWNTTSSSSS SC----FSST TTTKTKLVSL LSRIYVVVDD PPPKKYYCCQ ---------- ---------- ---------- ---------- ---------- PPPKKYYCCQ RLPMLKDLHG WWNTTSSSSS SC----FSST TTTKTKLVSL LSRIYVVVDD PPPKKYYCCQ RLPMLKDLHG WWNTTSSSSS SC----FSST TTTKTKLVSL LSRIYVVVDD PPPKKYYSSQ RLPMLKDLHG WWNTTSSSSS SC----FSST TTTKNKLVSF FSRIYVVVDD PPPKKYYCCQ RLPMLKDLHG WWNTTSSSSS SC----FSST TTTKTKLVSL L--------- PPPKKYYCCQ RLPMLKDLHG WWNTTSSSSS SC----FSST TTTKTKLVSL LSRIYVVVDD PPPSSYYSSQ RLPVIGDLHG WWNSSSSSSS SC----HPPS SSSARFLISL LGRVYVVVDD ---------- ---MTNDLHG WWNTTSSSSS SC----YAAS SSSKNKLICL LSRIYVVVDD PPPKKYYSSQ RLPMVNDLHG WWNTTSSSSS SC----YSSS SSSKNKLICL LSRIYVVVDD PPPSSYYSSK RLPVVGDLHG WWNSSSSSSS SC----HPPS SSSARFLISL LGRIYVIIDD PPPNNYYSSK RLPVVGDLHG WWNSSSSSSS SC----HPPS SSSARFLIGI IGRVYVIIDD ---------- ---MVGDLHG WWNSSSSSSS SC----HAAS SSSARYLVSL LGRIYAIIDD PPPSSYYSSS RLPMVGDLHG WWNSSSSSSS SC----HAAS SSSVRYLVSL LGRIYAIIDD PPPNNYYSSQ RLPVVGDLHG WWNAASSSSS SC----HPPS SSSARFLISL LGRVYVVVDD PPPEEFFCCQ RVDVIGDVHG WWNAASSSSS SC----HPPT TTTESHLICL LDRIYIIINN PPPEEFFCCQ RVDVIGDVHG WWNAASSSSS SC----HPPT TTTESHLICL LDRIYVIINN ---------- ---------- ---------- ---------- ------MVKL LGVEGKVVFF PPPAAYYCCQ RTYTKHNLHG WWNTTSSSSS SCHPPPGEEV VVVPDRLVCL LDRIFVIIDD PPPEEYYCCQ RTFTKGDLHG WWNAASSSSS SCYDDDSTTV VVVPDRLVSL LDFIYILLDD GGGQQGGGGS DGPVLEDEDQ PPTPPLLLLL LK-----RRV VVVQPQMLSL LKRLYVTTTT PPPGGRRGGQ SVSV-RNAHG FFSAA----- ---------- ----RFFWGL LNRIFIFFDD PPPKKYYGGK TLSV-RNAHD FFTDD----- ---------- ----RYLWGL LSKIFVFFDD PPPREEPKII IIVIEPPEEV VVKSGGGTVY YIISALLGNE EE-----EEE G--EEEEGPG PKKRRRPAVA AAIVEPPVVA AAVTGGGTVY YIISALLGGP PP-----DDD GRREEEEGPG PPPTQQARIH HHIIEPPEEI IILTGGGTVY YVVSTLLGGA AAGKKKKDDD GTTDDDDGAP PPPTKKAKIH HHIIEPPEEV VVFTGGGTIY YVVSTLLGGG GGGKKKKDDD GTTNNNNGPP -PPLKKAKIH HHIIEPPEEV VVFTGGGTIY YVVSTLLGGG GGGEEEEDDD GTTDDDDGPP PPPLKKPFLA AAVIEPPTTL LLATGGGTVY YVVTALLGNA AA-----EEE G--KKKKGPG PPPTQQPKVV VVVIDPPEEL LLATGGGTVY YIISALLGSP PP-----EEE G--EEEEGPG PPPREEPRIV VVVIEPPEEL LLHTGGGTIY YVVSALLGSP PP-----EEE G--DDDDGPG SPPRAAPKLH HHVIEAAEEI IIQCNNNTSV VMMVNTTLGD DD-----LLL QGGNNNNGKG SPPRAAPKLH HHVIEPPEEI IIHCNNNTSV VMMISSSLGD DD-----PPP QGGNNNNGKG SPPRAAPKLH HHVIEAADDI IIHCGGGTSV VMMISTTLGD DD-----SSS KGGNNNNGKG TPPRAAPKLH HHVIEPPDDI IIHCNNNTSV VMMVSTTLGD DD-----PPP EGGNNNNGKG SPPRAAPKLH HHVIEPPDDI IIHCEEETSV VMMISSSLGD DD-----VVV KGGNNNNGKG ---------- -----PPDDI IIHCEEETSV VMMISSSLGD DD-----VVV KGGNNNNGKG SPPRAAPKLH HHVIEPPDDI IIHCEEETSV VMMISSSLGD DD-----VVV KGGNNNNGKG SPPRAAPKLH HHVIEPPDDI IIHCEEETSV VMMISSSLGD DD-----VVV KGGNNNNGKG TPPRAAPKLH HHVIEAADDI IIHCGGGTSV VMMISTTLGD DD-----PPP KGGNNNNGKG ---------- ---------- ---------- ---------- ---------- ---------- SPPRAAPKLH HHVIEPPDDI IIHCEEETSV VMMISSSLGD DD-----VVV KGGNNNNGKD TPPRTTPSLH HHVVESSDDI IIAIGGGTSI IMMISCCLGD DD-----KKK EGGNNNNAAG TPPRAAPRIH HHTVEPPEEV VVFCGGGTSI IMMISSSIGD DD-----PPP YGGNNNNGKG SPPRAAPRIH HHTVEPPEEV VVFCGGGTSI IMMISSSLGD DD-----PPP CGGNNNNGKG TPPRSSPSLH HHVVDPPDDI IIITGGGTSL LMMISCCLGD DD-----KKK DGGNNNNAEG TPPRAAPSLH HHVVEPPDDI IISTGGGTSI IMMISCCIGD DD-----KKK DGGNNNNAEG EPPRAAPSLY YYYVDPPEEI IIATGGGTAI ILLVSCCLGD DD-----EEE EGGNNNNAKG EPPRAAPSLY YYYVDPPEEI IIATGGGTAI ILLVSCCLGD DD-----EEE EGGNNNNAKG KPPRAAPALH HHVVEAADDI IIATGGGTSI IMMISCCLGD DD-----KKK EGGNNNNAAG N--RKKIYLE EETIEPPKKL LLHN---TSI IMMISTTLGE EE-----AAA NGGTTTTPSG N--REEIYLQ QQTIEPPKKL LLHN---TSI IMMISTTLGE EE-----AAA DGGSSSSPSG G--------- ---------- ---------- ---------- ---------- ---------- TPPRAAPKLA AAVIEGGDDV VVLADDDTTI IMMISIIMGD DD-----AAA EGGNNNNAKG TPPRKKPEIV VVTIDGGDDV VVLHNNNTTI IMMISVVMGD DD-----AAA EGGYYYYAKG YAAWDDKQFY YY-----DDL LLILVVVTAL LKKQDGGVNE EE-----SSS LSSVVVVPVL SPPSNNPKLH HHTIDTTFFV VVKGGGGTFM MIITGLLSND DD-----DDD DHHGGGGGRT SPPARRPVLS SSTITDDFFV VVEGGGGTLL LIITGLLSNN NN-----KKK DHHGGGGGRT GIIMHHEPPP PGGKDRRDDD QQ-------- ---------- -LADWWWWLL -PNEEVEWVN GIILHHEPPP PGGRYRRPPP QQ-------- ---------- -FADWWWWLL -PSGGVEWVR GIIICCDVVV VGGRDRRPPP QQ-------- ---------- -KHDWWWWLL -PRDDYEWLP GVVICCEVVV VGGRDRRPPP QQ-------- ---------- -LHDWWWWLL -PRDDYEWLP GIIICCEIII IGGRDRREEE QQ-------- ---------- -KHDWWWWLL -PRDDYEWLP GIIMAAEPPP PGGRERRPPP QQ-------- ---------- -FADWWWWLL -GYDDTEWTD GIIIHHEVVV VGGRDRRDDD QQ-------- ---------- -LHDWWWWLL -GYDDTEWTR GVVVHHDPPP PGGRERRPPP QQ-------- ---------- -LADWWWWLL -GYDDTEWTN SFFLGGEVVV VGGTPGGAAA SS-------- ---------- -MGDWYYYPP -RHNNVEWAN GFFLGGEVVV VGGTPGGEEE AA-------- ---------- -MGDWYYYPP -RHNNIEWAN GFFLGGEVVV VGGTPGGAAA AA-------- ---------- -MGDWYYYPP -RHNNVEWAN GFFLGGEVVV VGGTPGGAAA AA-------- ---------- -LGDWYYYPP -RHNNVEWAN GFFLGGEVVV VGGTPGGAAA AA-------- ---------- -SGDWYYYPP -RHNNVEWAN GFFLGGEVVV VGGTPGGAAA AA-------- ---------- -LGDWYYYPP -RHNNVEWAN GFFLGGEVVV VGGTPGGAAA AA-------- ---------- -LGDWYYYPP -RHNNVEWAN GFFLGGEVVV VGGTPGGAAA AA-------- ---------- -LGDWYYYPP -RHNNVEWAN GFFLGGEVVV VGGTPGGSSS AA-------- ---------- -MGDWYYYPP -RHNNVEWAN ---------- ---------- ---------- ---------- ---------- ---------- GSSVPPECCC CGG------- ---------- ---------- ---------- ------ISHN NGGLDDNVVV VGGRRLLPPP II-------- ---------- -KETLYYYNN YAWGGLIQCL GFFLGGEVVV VGGNEGGAAA AA-------- ---------- -FGDWYYYPP -RHNNVEWAK GFFLGGEVVV VGGNEGGSSS AA-------- ---------- -FGDWYYYPP -RHNNVEWAK NGGLDDNVVV VGGRPGGSSS PP-------- ---------- -FGDWYYYPP -RHNNTSWAT NGGLDDNVVV VGGRPGGSSS PP-------- ---------- -FGDWYYYPP -RHNNTSWAK NGGLDDNIII INNRPGGSSS PP-------- ---------- -FGDWYYYPP -RHKKTSWAK NGGLDDNIII INNRPDDSSS PP-------- ---------- -YGHWYYYPP -RHKKTSWAK NGGLDDNVVV VGGRPGGSSS PP-------- ---------- -FGDWYYYPP -RHKKTSWAA NFFLGGEPPP PGGTDEETTT VV-------- ---------- -FNDWYYYPP -RRNNVEWSN NFFLGGEPPP PGGTDGGVVV VV-------- ---------- -FNDWYYYPP -RRNNIEWSN ---------- ---------- ---------- ---------- ---------- ------LRGV -DDVDDELLL LGGTGDDKKK AA-------- ---------- -CGDWYYYPP -HFNNVEWAK -DDIDDNCCC CGGTGDDKKK AA-------- ---------- -CGDWYYYPP -YFDDVEWAN NGGQKKGLLL LAAKSQQEEE EE-------- ---------- -LQSHNNNGG --REEKRPEI ALLEDDYVVV VTTYTAADDD MMAAAAAVGG GDDDAAAAAD DYGDRAAAII -RKNNVSFGS ALLENNYVVV VTTHTDDDDD LLAAAKKTGG G---KKKAAD DYDDRAAAPP -RKNNLSFGN NTEEEEGG-K KLEHLKKDRY YYGRFFWDLR RKKKRLTTTL RMA------E EELRDPTTKK RCEEEEGG-S SLECLKKEAY YYGKVVWDLA AKKKHIDDDL RMV------E EEVRDPTTKK PQEEEEGG-V VPEDLLLAKY YYGRFFWDLR RAAANIDDDL QMA------E EEVRDPVVRR PQEEEEGG-V VPEDLLLSKY YYGRFFWDLR RAAANIDDDL QMA------E EEVRDPVVRR PQEEEEGG-V VPEDLLLSKY YYGKFFWKLR RDDDNIDDDL QMA------E EEIRDPSSKK DMEEEEGG-V VPDILLLGRY YYGRFFWDLT TRRRHIDDDF QLV------E EELRDPTTKK RMEEEEGG-L LGDELLLAKY YYGRVVWDLY YRRRHLDDDL QMA------E EELRDPTTKK NMEEEEGG-D DPQILLLNGY YYGRIIWDLR RRRRHLDDDV QMV------E EELRDPAARR NVKKKKGGFP PAHVEAA-LY YYGRVVWDWQ QRRRILQQQM GLI----LLE EEIRDPSSAA NVKKKKGGFP PAHVEAA-LY YYGHVVWDWQ QRRRILQQQM GLI----LLE EEIRDPDDAA NVRRRRGGFP PADVEAA-LY YYGHVVWDWQ QRRRILTTTL GLI----LLE EEIRNPDDAA NVRRRRGGFP PADVKAA-LY YYGHVVWDWQ QRRRILPPPL GLI----LLE EEIRNPDDAA NVRRRRGGFP PADVEAA-LY YYGHVVWDWQ QHHHILSSSL GLI----LLE EEIRNPDDAA NVRRRRGGFP PADVEAA-LY YYGHVVWDWQ QRRRILSSSL GLI----LLE EEIRNPDDAA NVRRRRGGFP PADVEAA-LY YYGHVVWDWQ QRRRILSSSL GLI----LLE EEIRNPDDAA NVRRRRGGFP PADVEAA-LY YYGHVVWDWQ QRRRILSSSL GLI----LLE EEIRNPDDAA NVQQQQGGFP PADVEAA-LY YYGHVVWDWQ QRRRILLLLM GHI----LLE EEIRDPAAAA ---------- ---------- ---------- ---------- ---------- ---------- NLLLLLGGSD DYPASAA-RV VVAI------ ---------- ---------- ---------- LFTTTTGGAL LMCLTAA-GV VVHILLDNYI IMMMILPPPL QAGNNNNLLC CCLRWKNNII KAAAAAGGFM MEEVQAA-MY YYGSVVWDWT TEEERIDDDL GLI----LLE EEIRDPDDAA KAAAAAGGFM MEDVQAA-HY YYGSVVWDWT TEEELIDDDL GLI----LLE EEIRNPDDAA TATTTTGGFL LQHVADD-LY YYGHCCIQLA ARRRLLDDDL GLL----LLE EEIRDPAAKK KALLLLGGFL LQHVADD-LY YYGHVVYSWP PGGGILDDDL GLL----LLE EEIRDPAAKK KASSSSGGFL LQHVADD-LY YYGHVVYSWP PGGGMIDDDL GLL----LLE EEIRDPSSKK KASSSSGGFL LQHVADD-LY YYGHVVYSWP PGGGIIDDDL GLL----LLE EEIRDPSSKK AARRRRGGFL LQHVQDD-LY YYGHVVYDWP PGGGLLDDDL GLL----LLE EEVRDPSSKK NHKKKKGGFP PAHVGEE-LY YYGSIIFEWD DSSSYIDDDL GAL----LLE EEVREPTTSS NHKKKKGGFP PAHVPEE-LY YYGSIIFEWD DTTTHIDDDL GAL----LLE EEVREPTTSS VTCCCCDDEL LKCQPEE-LV VVICVVY--- ---------- ---------- ---------- KLRRRRGGYP PTDCDDDRQY YYGRFFYRWQ QEEELIDDDL GLT----LLE EEIRNPRREE NKRRRRGGWN NVDLEDDMQY YYGRFFYKWS STTTLIDDDL GIT----LLE EEIRNPKKKK IMFFFFSSSS SFLKKTTGLK KKPHEEVL-- ---------- ---------- ---------- SMDDDDGGQL LQDAEAAMRF FFGTQQWDLH HTTTPFNNNV -------LLE EEIRGSNNAA NMDDDDGGKL LADPEAAMHF FFGTTTWDLH HTTTPFDDDV -------LLE EEIRGEAAHH LFFNMVSSLK KDDLSSSIWW LLWF--KNNE KVVVIIIAPP G-PEEEILPP FKAVPLLVVD LFFNVVNNTK KDDLSSSIWW LLWF--KQQE RVVVIIIAPP G-PPPPVLDD FKMVPLLVVD EFFGVVDDTT TNNLESSIWW TTWW--KHHK KTTTAIIAPP ADPPPPLLGG FGAVPLLVVD EFFGVVDDTT TNNLESSIWW TTWW--KHHE KTTTAIIPPP KEPPPPLLGG FGAVPLLVVD DFFGVVDDTT TNNLQAAIFF TTWWKKTEEK KTTTIIIPPP ADPDDDLLGG FGACPLLVVD AFFNCVSSLK KDDLSSSIWW TTWY--KAAR KVVVIIIAAA PDPPPPVLGG FKAVPLLVVD AFFNCVSSLK KDDLSSSIWW LLWY--SHHK KVVVIIIAPP EDPPPPILPP FKAVPLLVVD TFFGVVSSLE EDDLSSSVWW LLWH--SGGR KVVVIIIAPP PDPPPPLLDD FGAVPLLVVD TFFGCASSSN NIIQRYYKNN EEEG------ ----TSSEVV VPKVVVKGMM LPEMPLLIID TFFGCASSSN NIIQRYYKNN EEGG------ ----TSSEVV VPKVVVKGMM LPEMPLLIID AFFGCASSST TIIQRYYKNN QQGG------ ----TSSEVV VPKVVVKGMM LPEMPLLIID AFFGCASSST TIIQRFFKNN EEDG------ ----TSSQVV VPKVVVKGMM LPEMPLLIID AFFGCASSST TIIQRYYKNN EEGG------ ----TSSEVV VPKVVVKGLL LPEMPLLIID AFFGCASSST TIIQRYYKNN EEGG------ ----TSSEVV VPKVVVKGLL LPEMPLLIID AFFGCASSST TIIQRYYKNN EEGG------ ----TSSEVV VPKVVVKGLL LPEMPLLII- AFFGCASSST TIIQRYYKNN EEGG------ ----TSSEVV VPKVVVKGLL LPEMPLLIID SFFGCASSST TIIQRYYKNN EEGG------ ----TSSEVV VPKVVVKGMM LPEMPLLIID ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NYYVVESSFS SGGRGSSDPP DDAY------ ----AVVKKK LYVVVVAKGG VVSLSEEFFP ALLGCASSST TVVFRYYKEE KKDG------ ----KAAEVV VPKVVVEGAA LPEMPLLIID DLLGCASSSS SIIFRYYKEE KKDG------ ----KAAEVV VPKVVVEGPP MPEMPLLIID DFFGSASSSN NMMIRFFKTT QQDG------ ----SSSEAA VKKVVVQNII LPEMPLLIID DFFGSATTSN NMMIRFFKTT QQDG------ ----SNNEVV VEKVVVQNFF LPEMPLLIID DYYGSASSSN NMMIRFFKNN SSDD------ ----TSSEVV VKKVVVENII LPEMPLLIID DFFGSASSSN NMMIRFFKNN SSDE------ ----TSSEVV VKKVVVENII LPEMPLLIID DYYGCATTSN NMMVRFFKTT AADG------ ----SSSEAA IKKVVVRNII LPEMPLLIID EFFGCAGGSG GIIFRHHPVV EEEN------ T---TAATVV IPKVVVSGAA LPEMPLLIID EFFGCAGGSA AIIFRHHPDD EEKN------ K---VTTSVV IPKVVVENAA LPDMPLLIID ---------- ---------- ---------- ---------- ---------- ---------- NYYGCAXXXX XXXXXXX--- ---------- ---------- --QGGGENEE IEMMGMMMMD AFFGCANNAK KVVFHKKKKK SSDS------ EFFFEKKVDD GKDTTTGSVV AEDMGMMIID ---------- ---------- ---------- ---------- ---------- ---------- NFFTTATTSQ QLLWLYYEDD DDAG------ ---------- WQAVVVADGG NPADILLPPD NFFSTATTSQ QLLWLYYEDD GGEG------ ---------- WQAVVVADGG EPAKVLLPPD DDIDDISSSL LLDDDLYYYL LLIGVVRRQD DDIIIISPKV VTTTTKVVFH RADH------ DDIDDISSSL LLDDDLYYYV LLLGLLRRQD DDIIIITPQR RAAAARVVYH REPH------ DDIDDLSSSL LLDDDLYYYV CCTGMMRRQD DDVVVVSPNV VAAAASVVAR RAPH------ DDIDDLSSSM MMDDDLYYYV CCTGMMRRQD DDVVVVSPKK KAAAASVVAR RTPH------ DDIDDLSSSL LLDDDLYYYV CCLGMMHHQD DDVVVVSPNV VTTTTKVVVK KTPH------ DDIDDLSSSM MMDDDLYYYV CCTGLLLLQD DDVVVVSPEK KTTTTKVVVS RATH------ DDINNLSSSV VVDDDLYYYV CCTGLLHHQD DDVVVVSPNR RTTTTKVVVR RAGH------ DDINNLSSSL LLDDDLYYYV CCTGLLRRQD DDVVVVSPNR RTTTTSVVVR KAAH------ DDILLLSSSL LLDDDLYYYF NNHGIIRRQD DDIIIISPKR RTTTTQIIIV RGGSVLE--- DDILLLSSSL LLDDDLYYYF NNHGIIRRQD DDIIIISPKR RTTTTQIIIV KGGSVLE--- DDILLLSSSL LLDDDLYYYF NNHGLLRRQD DDIIIISPRR RTTTTQLLIV KGGPVLE--- DDILLLSSSL LLDDDLYYYF NNHGIIRRQD DDVVVVSPRR RTTTTQLLIV KDGPVLD--- DDILLLSSSL LLDDDLYYYF NNHGLLRRQD DDIIIISPRR RTTTTQLLIV KGGPVLE--- DDILLLSSSL LLDDDLYYYF NNHGLLRRQD DDIIIISPRR R--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDILLLSSSL LLDDDLYYYF NNHGLLRRQD DDIIIISPRR RTTTTQLLIV KGGPVLE--- DDILLLSSSL LLDDDLYYYF NNHGMMRRQD DDIIIISPRR RVVVVQIIIV KGGPVLE--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPAWWIFFFF FFSSDIIIIF SS-------- ---------- ---------- ---------- DDILLISSSL LLDDDLYYYF NNHGIIRRQD DDIIIITPNK KVVVVQIIIL RGGPVLE--- DDILLISSSL LLDDDLYYYF NNHGIIRRQD DDIIIITTNK KVVVVQIIIQ RGGPVLE--- DDFLLISSSL LLDDDLYYYF NNHGIIRRQN NNIIIIELNV VTTTTQLLIQ KGSPAIG--- DDFLLISSSL LLDDDLYYYF NNHGIIRRQN NNIIIIEVNK KTTTTQVVIQ KGSPAVK--- DDFLLISSSL LLDDDLYYYF NNHGIIRRQN NNIIIIEPNV VTTTTQIILQ KGSPAVG--- DDFLLISSSL LLDDDIYYYF NNHGIIRRQN NNIIIIEPNV VTTTTQIILQ KGSPAVG--- DDFVVISSSL LLDDDLYYYL NNHGIIRRQN NNIIIIEPKV VAAAAQVVLQ KGSEYVT--- DDILLISSSM MMDDDLYYYV CCHGIIRRQD DDIIIISPKK KNNNNQVVVH TESNVLE--- DDILLISSSM MMDDDLYYYV CCHGIIRRQD DDIIIISPNK KNNNNQVVIH SETTVLE--- ---------- ---------- ---------- ---------- ---------- ---------- DDILLISSSL LLDDDLYYYF NNHGVVRRQD DDIIIISRNR RTTTTQVVIQ RDAPVLN--- DDIIIISSSL LLDDDLYYYV CCHGVVRRQD DDIIIITPNK KTTTTQLLIC SDLPIVKEEE ---------- ---------- ---------- ---------- ---------- ---------- DDISSIAAAA AADDDLWWWI SSDGTTRRLD DDIIIISPKF FIIIIEKKVN ---------- DDISSISSSN NNDDDLWWWV TTDGTTRRLD DDIIIISPHR RVVVVEKKVN ---------- ---------- AKKKGGAPQQ MLLIIRDDGG RRRRRYYYVV NSSYYSTWDN NYPEEGLKVV ---------- SEEEGGAPQQ MIIVVRDDGG RRRRRYYYII NSSYYSSWNN NYP--GLRAA ---------- NTTTGGGPQQ MVVIIRDDGG RRRRRYYYWW NSSYYSTWDD DYPDDGVPVV ---------- NAAAAAGPQQ MVVIIRDDGG RRRRRYYYWW NSSYYSTWDD DYPDDGVPVV ---------- NTTTYYGPQQ MVVIIRDDGG KKRRRYYYWW NSSYYSTWDE EYPGGDRGVV ---------- KAAAGGGPQQ MVVIIRDDGG RRRRRYYYFF NSSYYGAVDP PYPEEGIDVV ---------- TEEEGGGPQQ MVVIIRDDGG RRRRRYYYFF NSSYYRAWDE EYPDDGIKVV ---------- APPPGGGPQQ MVVVVRDDGG RRRRRYYYFF NSSYYASWDE EYPVVGIRAA DELLCQPPVV KRRRGGGPQQ MIILLLDDGG KKRRRYYYAA TSSYYSDWDK KY-PPDLISS DELLCQPPVV KRRRGGGPQQ MIILLLDDGG KKRRRYYYVV TSSYYSAWDK KY-PPNLISS DELLSQPPVV KKKKGGGPQQ MIILLLDDGG KKRRRYYYVV TSSYYSAWDK KY-PPDLISS DELLSQPPVV KQQQGGGPQQ MIILLLDDGG KKRRRYYYVV TSSYYSAWDK KY-PPDLISS DELLSQPPVV KRRRGGGPQQ MIILLLDDGG KKRRRYYYII TSSYYSAWDK KY-PPDLISS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DELLSQPPVV KRRRGGGPQQ MIILLLDDGG KKRRRYYYII TSSYYSAWDK KY-PPDLISS DELLSQPPVV KRRRGGGPQQ MIILLLDDGG KKRRRYYYVV TSSYYSDWDK KY-PPDLISS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDLLCQPPII KKKKGGGPQQ MIILLLDDGG KKRRRYYYVV NSSYYSKWDK KY-PPDMISS DELLCQPPTT KIIIGGGPQQ MIILLLDDGG KKRRRYYYVV SSSYYSIWDK KY-PPDLLAA EGKKWQVVEE QKKKGGGPQQ MIILLLDDGG KKRRRYYYVV NSSFFSAWDK KY-PPGLVSS DGEEWQVVEE QKKKGGGPQQ MIILLLDDGG KKRRRYYYVV NSSFFSAWDK KY-PPKLVSS EGNNFQVVQQ KSSSGGGPQQ MIILLLDDGG KKRRRYYYAA NSSFFSAWDR RY-PPELMSS EGNNFQVVQQ KSSSGGGPQQ MIILLLDDGG KKRRRYYYAA NSSFFSAWVV VY-PPEIMSS EDKKEQVVQQ KRRRGGGPQQ MIILLLDDGG KKRRRYYYVV NSSFFSRWDE EYGQQDLVSS GK---PAAYY KKKKGGGPQQ MLLLLLDDGG KKRRRYYYVV TSSYYKKWDD DY-PPEHVAA EHDD-EAAYY KQQQGGGPQQ MLLLLLDDGG KKRRRYYYVV TSSYYKKWDD DY-PPENVAA ---------- ----GGGPAA KIILLVDDGG KKRRRYYYVV NSSYYSTWDK KY-PPNVVSS DELLEAPPFF KRRRGGGPQQ MLLLLLDDGG RRRRRYYYVV SSSFFSPWDK KY-PPEMVGG DELLERAAYY KRRRGGGPQQ MLLLLLDDGG KKRRRYYYVV SSSYYSPWDK KY-PPKMVGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MVVQQWDDGG KKRRRYYYFF SSSLLANWD- --------KK ---------- ---------- MVVSSWDDGG QQRRRYYYYY SSSLLANWD- --------KK KLLLA---PS SSGEEIIIKK KEFVVDDFGE ---RRSSSRL SGGGGGGASS SSYYY----- KVVVV---PE EEGEELLLKK KEFVVDDFGR ---RRAAARL WGGGGGGATT SSFFF----- LAAAA---PD DDGTTLLLDD DDWVVEEFPD G--RRAAARL EGGGGGGCTT SSFFFSVVVK MAAAV---GN NNGEELLLKK KDFVVSSFPD G--RRAAARL EGGGGGGCTT SSFFFSVVV- MAAAV---EN NNGTTLLLKK KDWVVDDFPA G--RRSSSRL EGGGGGGCTT SSFFFSVVV- KLLLA---PN NNGEEFFFPP PKFLLEEWPK G--RRPPPRL QGGGGGGCSS SSYYY----- KVVVV---PD DDGQQFFFPP PNFVVDDFGE ---RRVVVRL QGGGGGGASS SSYYY----- KAAAA---PG GGGSSLLLPP PGFTTEEVGD G--RRPPPRL EGGGGGGSSS SSYYYS---- VMMMQDVDVN NNGKKLLLPP PNLVVDDFGK EGPLLAAARY PGGGGGGCSS IIWWW----- VMMMQDVDAN NNGKKLLLPP PNLVVDDFGK EGPLLAAARY PGGGGGGCSS IIWWW----- VMMMQDVDVK KKGKKLLLPP PNLVVDDFGK EGPLLAAARY PGGGGGGCSS IIWWW----- VMMMQDVDVK KKGTTLLLPP PNLVVDDFGK EGPLLAAARY PGGGGGGCSS IIWWW----- VMMMQDVDVK KKGKKLLLPP PNLVVDDFGK EGPLLAAARY PGGGGGGCSS IIWWW----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VMMMQDVDVK KKGKKLLLPP PNLVVDDFGK EGPLLAAARY PGGGGGGCSS IIWWW----- VMMMQDVDVK KKGKKLLLPP PNLVVDDFGK EGPLLAAARY PGGGGGGCSS IIWWW----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VMMMQDVDEK KKGKKLLLPP PNLVVDDFGK EGPLLAAARY PGGGGGGCSS IIWWW----- VMMMQDVDKK KKGKKLLLPP PNLVVDDFGK EGPLLAAARY PGGGGGGCSS IIWWW----- HIIIQDVDEK KKGKKIIIPP PNFVVDDFGA EGPLLAAARY PGGGGGGCSS IIWWW----- HIIIQDVDEN NNGKKIIIPP PNFVVDDFGA EGPLLAAARY PGGGGGGCSS IIWWW----- HIIIQDVDEK KKGSSIIIPP PNFVVDDFGD EGPLLAAARY PGGGGGGCSS IIWWW----- HIIIQDGDEK KKGTTIIIPP PDFVVDDFGD EGPLLAAARY PGGGGGGCSS IIWWW----- HMMMQDVDEK KKGSSIIIPP PNFVVDDFGA EGPLLAAARY PGGGGGGCSS IIWWW----- TMMMQNIDES SSKEEIIIRR RDLIIDDFGK IGPLLAAARY PGGGGGGCSS IIWWW----- TMMMQDVDIT TTHVVIIIKK KNLIIDDFGK VGPLLAAARY PGGGGGGCSS IIWWW----- VMMMQDVDEK KKGTTVVVKK KNLVVDDFGK EGPLLAAARF PCCCCGGSSS IILLL----- TIIIQDIDEN NNGKKLLLEE ENLVVDDFGG EGPLLPPPR- ---------- ---------- HIIILDVDVN NNGSSLLLEE EDLVVDDFAN EGPLLPPPRY PGGGGGGCSS IIWWWDAAA- ---------- ---------- ---------- ---------- ---------- ---------- DDDDQLKANW WWGEELLLEE EDAVVDDFYE LG-RRAAARF GSSSSSSLSS ---------- DDDDQLKLYW WWGEELLLEE EQAIIDDFYA EG-RRPPPRF GAAAARRLAA PPAAANRRRL ------- ------- RR----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- VVARRRV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNNNNNAKA KKKKQPPSTP CPPTGGGTAA AALADDGQSS SLLLPRTQLL LSLLTPGGGS gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSSSSVVVVR IIIKKAYEEA WWWSSAILAA SSSESSKGTT RRSVLLVSSS SAAVKQVVVS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MGGS AAAPPPLRTT PTPNPPLASS PPPHVVPRRR LVVRYRIIIV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M MMAAIIPFKK RRDDPPPTFP ---------- ---------- ---------- ---------- ----MMKLKK PPDDPPPTFP ---------- ---------- ---------- ---------- ------SMRR PPDDPPPTFP ---------- ---------- ---------- ---------- ------TMRR PPDDPPPTFP ---------- ---------- ---------- ---------- ------TLRR PPDDPPPTFA ---------- ---------- ---------- ---------- ----MMTWKK PPDDPPPSFP ---------- ---------- ---------- ---------- ----MMTWRR PPDDPPPTFP ---------- ---------- ---------- ---------- ----MMSWRR PPDDPPPTFP ---------- ---------- ---------- -------AAT TTKKCCK--- CCGGPPPGYL ---------- ---------- ---------- ---------- ---------- ---------- AAQWWWHHWW LLPGGKKHHG GGAAAVLLIA APAAGPASST TTQQCCK--- CCGGPPPGYL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AAT TTKKCCN--- CCGGPPPGYL ---------- --ARRAAEEG GGAAFTLLQS SVAAPPSAAT TTKKCCN--- CCGGPPPGYL ---------- ---------- ---------- -------AAT TTKKCCN--- CCGGPPPGYL ---------- ---------- ---------- -------AAT TTKKCCN--- CCGGPPPGYL ------MMGG LLGEEEEPPG GGHHTAQQPW WFLLGWDAAT TTKKCCD--- CCGGPPPGYQ ---LLLKKNN SSQCCLLGGF FFDDQTNNTE ELHHYLTPPT TTKKCCN--- CCGGPPPGYL ---------- ---------- ---------- -------AAT TTKKCCN--- CCGGPPPGYL PRPCCCPPHH AARSSLLVVL LLQQHIMMEG GAAAVAAGGK KKTTCCHTAA KKGGPPPGYL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMA AAKKCCS--- CCGGPPPGYL ---------- ---------- ------MMAT TVLLHVKSS- --VVNNCCKK SSGGPPPGYI ---------- ---------- ------MMGT TVLLHVKNNN NNQQQQCCKK SSGGPPPGYL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RRLQVV GGGGPPPGYL ---------- ---------- ---------- -----AAGGA AAAACCGGAA TTGGPPPGYL ---------- ---------- ---------- -----MNGGL LLKKCCG--- --GGPPPGYA ---------- ---------- ---------- -----M-PPL LLKKCCG--- --GGPPPGYA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M MMSSEEKCKK CCGGPPPGYL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMPPPGL- ---------- MMKRREEFFG GG-------- ----AAAAAM MMGGLLFRAA FFAADDDETP ---------- MMKFFIIVVS SSGGPSMMHF FALLASAAAL LLAAAAAGVV RRAADDDETP AAPEEEELLY VVVACLLTTT TGRRADAAVV VPPKSTTTVV KELYYIHHHF GWWNNAACSA AAPEEEEIIY VVVAALLVTT TGAAPDAAVV VPPKSTTTII KDLYYIHHHF GWWNNAACSA AAPEEEEFFY TTTLLLLPFF FSRRPDAAVI VPPGSTTTVV TTMNNTHHHF GWWNNAACSS AAPEEEEFFY TTTLLLLPFF FSKKPDAAVI VPPGSTTTVV TTMNNKHHHF GWWNNAACSA AGPEEEELLF TTTLMLLPAA ASKKPDAAVV VPPTSKKKVV QIMNNKHHHF GWWNNAACSA AAPEEEEIIY VVVAMFFPRR RKQQPDAAVV VPPASRRRVV QAMHHAHHHF GWWNNAACSC AAPEEEELLY VVVVRLLPAA ANKKPDCCVV VSSQSTTTVV VDMYYTHHHF GWWNNAACSM AAPEEEELLY VVVALLLPRR RERRPDGGVL LPPDSTTTVV REMNNAHHHF GWWNNAACAA MGPEEEEIIY LLLPCIIRTT TGAAPDAATV VPPKSQQQII RPMYYLHHHS GWWNNTTCSC -GPEEEEIIY LLLPCIIRTT TGAAPDAATV VPPKSHHHII RPMHHLHHHS GWWNNTTCSC MGPEEEEIIY LLLPCIIGTT TGAAPDAATV IPPKSQQQII RPMNNLHHHS GWWNNAACSC MGPEEEEIIY LLLPCIIRTT TGAAPDAATV VPPKSQQQII RPMHHLHHHS GWWNNTTCSC MGPEEEEIIY LLLPCIIRTT TGAAPDAATV VPPKSQQQII RPMNNLHHHS GWWNNTTCSC MGPEEEEIIY LLLPCIIRTT TGAAPDAATV VPPKSQQQII ---------- ---------- MG-------- ---------- --AAPDAATV VPPKSQQQII RPMNNLHHHS GWWNNTTCSC MGPEEEEIIY LLLPCIIRTT TGAAPDAATV VPPKSQQQII RPMNNLHHHS GWWNNTTCSC MGPEEEEIIY LLLPCIIRTT TGAAPDAATV VPPKSQQQII RPMYYLHHHS GWWNNTTCSC MGPEEEEIIY LLLPCIIRTT TGAAPDAATV VPPKSQQQII RPMNNLHHHS GWWNNTTCSC MGPEEEEIIY LLLPCIIRTT TGAAPDAATV VPPKSQQQII RPMNNLHHHS GWWNNTTCSC MGPEEEELLY VVVTCVVNTT TGKKLDAATV LPPSSTTTII RPVHHIHHHS GWWNNSSCSC ---------- ---------- ---------- ---------- --MNNTHHHS GWWNNTTCSC MGPEEEEIIY LLLPCIIRTT TGKKPDAATV VPPKSSSSII RPMNNVHHHS GWWNNTTCSC MGPEEEELLY VVVTAVVATT TGKKPDAATV VPPSSTTTII RPVYYVHHHT GWWNNSSCSC MGPEEEELLY VVVTAVVATT TGKKPDAATV LPPNSTTTII RPVYYVHHHT GWWNNSSCSC ---------- ---------- ---------- ---------- --MFFVHHHS GWWNNSSCSC MGPEEEELLY VVVTAVVTTT TGKKPDAATV VPPSSSSSII RPMFFVHHHS GWWNNSSCSC MGPEEEELLY VVVTCVVNTT TGKKPDGGTV VPPNSTTTII RPVHHVHHHS GWWNNAACSC IGPEEEEVVF VVVTAPP-NN NAGGPDFFTV VPPESTTTII RDVHHIHHHT GWWNNAACSC IGPEEEEVVF VVVTAPP-HH HAGGPDFFTV VPPESTTTII RDVNNIHHHT GWWNNAACSC ---------- ---------- ---------- ---------- ---------- ---------- VGPEEEELLY VVVVCVVPLL LDHHGDAATV VPPASTTTII RYTSSKHHHS GWWNNTTCSC MGPEEEELLY TTTVTVVPLL LDHHGDSSTV VPPESTTTVV RFTRRKHHHS GWWNNAACSC LLDRRRRLLF SSSNWLLGII IRDDITKKNP MGGQVLLLLL DPVVVLLLLS QPPTTPPRLK PTGEEEEFFY VVVWTLLVGG GMEEQDVVTI LPPGSTTTII SSVGG-HHHG GFFSSAA--- KTGEEEEYYY VVVWTLLAGG GVEEQDVVTV APPKSQQQVV TSVGG-HHHS DFFTTDD--- LCCPKKNNER RFLLIPPRSR IIITKKPPPP PREEIIIPEE EVKVSSSRLH TVCGGPPPDA YCCPKKFFER RYLLIPPRSR IIVTKKKKKK KRRRVAAPEE EAGRTTTKYH TVCGGPPPDA LSSPHHFFER RFLLIPPRSR IVITKKPPPP PTQQIHHPDD DIAKTTSRPH TVCGGPPPEG LSSPHHFFER RYLLIPPRSR IIITKKPPPP PTKKIHHPEE EVKKTTSRPH TICGGPPPDG LSSPHHFFER RYLLIPPRSR IIVVKKPPPP PLKKIHHPEE EVAKTTSRPH TICGGPPPEG LCCPHHHHER RYLLVPPRSR IILTKKPPPP PLKKLAAPEE ELERTTSRPH TVCGGPPPGG LCCPHHHHER RYLLVPPRSH IILTKKPPPP PTQQVVVPNN NLERTTARPH TVCGGPPPDG LCCPHHHHER RYLLIPPRSR IIVTKKPPPP PREEIVVPEE ELRRTTSRPH TICGGPPPDG ----DDTTSR NKLLIPPMSR IVVVGGPPPP PRAALHHASS SIAKCCSNTH TSCLLAAASG ----DDTTSR DKLLIPPISR IVVVGGPPPP PRAALHHPNN NIAKCCGNLH TSCLLAAASG ----DDTTSR TKLLMPPMSR IVVVGGPPPP PRAALHHAEE EIAKCCGYVH TSCLLAAASG ----DDTTAR TKLLVPPISR IVVVGGPPPP PRAALHHPKK KITKCCGFFH TSCLLPPPSG ----DDTTSR TKLLVPPISR IVVVGGPPPP PRAALHHPEE EIAKCCAFLH TSCLLAAASG ---------- ---------- ---------- -------PKK KIAKCCAFLH TSCLLAAASG ----DDTTSR TKLLVPPISR IVVVGGPPPP PRAALHHPKK KIAKCCAFLH TSCLLAAASG ----DDTTSR TKLLVPPISR IVVVGGPPPP PRAALHHPKK KIAKCCAFLH TSCLLAAASG ----DDTTSR NKLLVPPISR IVVVGGPPPP PRAALHHAKK KIEKCCGTPH TSCLLPPPTG ----DDTTSR TKLLVPP--- ---------- ---------- ---------- ---------- ----DDTTSR TKLLVPPISR IVVVGGPPPP PRAALHHPKK KIAKCCAFLH TSCLLAAASG ----DDSSKR RFLLIPPLGR VVVTAAPPPP PRTTLHHSEE EIENIIGFPH TSCLLAAASG ----DDSSVR NKLLIPPISR IVVVGGPPPP PRAAIHHPYY YVWKCCANLH TSCLLGGGCG ----DDSSVR NKLLIPPISR IVVVGGPPPP PRAAIHHPYY YVWKCCANPH TSCLLGGGCG ----DDSSER RFLLIPPVGR IVITKKPPPP PRSSLHHPAA AIQKTTAYPH TSCLLAAASG ----DDSSQR RFLLIPPVGR VVITKKPPPP PRAALHHPEE EITKTTAYPH TSCLLAAASG ----DDSSDR RYLLVPPIGR IAITKKPPPP PRAALYYPKK KIEKTTAYPH TACLLAAASG ----DDSSDR RYLLVPPIGR IAITKKPPPP PRAALYYPKK KIDKTTAFPH TACRRTTT-G ----DDSSSR RFLLIPPLGR VVVTLLPPPP PRAALHHAEE EIEKTTGFPH TSCLLAAASG ----KKTTKR SHLLIPPNDR IIIVEE---- -RKKLEEPSS SLSLNNSFPH TSCLLAAADG ----KKTTKR SHLLIPPNDR IVIVEE---- -REELQQPSS SLALNNSFPH TSCLLAAADG ---------- --MMVRRSGV EKVVGG---- ---------- ---------- ---------- HFFPKKVVTR DRLLVPPNDR IVITGGPPPP PRAALAAG-- -VKGAATAPH TTCLLPPPNG YYYDKKVVKR DRLLVPPNDF IILVVVPPPP PRKKIVVG-- -VKSHHTAPH TTCLLAAANG ----KKVVGG PQMMLLLDKR LVTSLLAAAA AWDDFYY--- -LKFLLAISH TAYQQPPPNT --------DR RFFFWGGDNR IIFVHHPPPP PSNNLHHT-- -VDSGGVGPH TFALLPPPGS --------DR RYLLWGGDSK IVFVHHPPPP PARRLSSD-- -VKSGGVGPH TLALLPPPGR AIYYIAALNN E-EGGG--EE GGGLLLLLHY SSPKWIIRRG QYYYY----- ---------L AIYYIAALGG P-DGGGRREE GGGFFFFLHD TTPRWVVRRG QYYYY----- ---------F GIYYVTTLGG AKDGGGTTDD PGGFFFFMCE TTVRWIIRRG QDDDD----- ---------K GIYYVTTLGG GKDGGGTTNN PGGFFFFMCE TTVRWIIRRG QTTTT----- ---------L GIYYVTTLGG GEDGGGTTDD PGGFFFFLCE TTIRYMMRRG QTTTT----- ---------K GIYYVAALNN A-EGGG--KK GGGAAAALAQ SSPRWVVRRG QYYYY----- ---------F GIYYIAALSS P-EGGG--EE GGGFFFFLHD NNVRWIIRRG QYYYY----- ---------L GVYYVAALSS P-EGGG--DD GGGFFFFMHE SSPRWVVRRG QQQQQ----- ---------L GEVVMNNTGG D-LQQQGGNN GSSVVVVLGE TTVTWKKGGG SPPPP----- ---------M GEVVMSSSGG D-PQQQGGNN GGGVVVVLGE TTVTWKKGGG APPPP----- ---------M GEVVMSSTGG D-SKKKGGNN GGGVVVVLGE TTVTWQQGGG APPPP----- ---------M GEVVMSSTGG D-PEEEGGNN GGGVVVVLGK TTVTWQQGGG APPPP----- ---------L GEVVMSSSGG D-VKKKGGNN GGGVVVVLGE TTVTWRRGGG APPPP----- ---------S GEVVMSSSGG D-VKKKGGNN GGGVVVVLGE TTVTWRRGGG APPPP----- ---------L GEVVMSSSGG D-VKKKGGNN GGGVVVVLGE TTVTWRRGGG APPPP----- ---------L GEVVMSSSGG D-VKKKGGNN GGGVVVVLGE TTVTWRRGGG APPPP----- ---------L GEVVMSSTGG D-PKKKGGNN GGGVVVVLGE TTVTWRRGGG APPPP----- ---------M ---------- ---------- ---------- ---------- ---------- ---------- GEVVMSSSGG D-VKKKGGNN DGGLLLLLP- RRC------- ---------- ---------- GDIIMSSCGG D-KEEEGGNN GNNFFFFLDS EEVRGNNLLF ISSSS----- ---------K GEIIMSSSGG D-PYYYGGNN GGGVVVVLGE TTVNWAAGGE APPPP----- ---------F GEIIMSSSGG D-PCCCGGNN GGGVVVVLGE TTVNWVVGGE AQQQQ----- ---------F GELLMSSCGG D-KDDDGGNN GNNFFFFLDS DDVRWKKGGH PLLLL----- ---------F GEIIMSSCGG D-KDDDGGNN GNNFFFFLDS EEVRWKKGGH PLLLL----- ---------F GEIILSSCGG D-EEEEGGNN GNNFFFFLDS DDIRWKKGGH PLLLL----- ---------F GEIILSSCGG D-EEEEGGNN GNNLLLLLDS DDIRWKKDDI PLLLL----- ---------Y GEIIMSSCGG D-KEEEGGNN GNNFFFFLDS EEVRWKKGGH PLLLL----- ---------F GNIIMSSTGG E-ANNNGGTT GNNLLLLLGK TTPTWAAEEK VPPPP----- ---------F GNIIMSSTGG E-ADDDGGSS GNNLLLLLGK TTPTWAAGGK VPPPP----- ---------F ---------- ---------- ---------- ---------- ---------- ---------- GNIIMSSIGG D-AEEEGGNN G--FFFFEDK NNLTWRRDDR ALLLL----- ---------C GNIIMSSVGG D-AEEEGGYY G--FFFFLDS DDCTWKKDDK ALLLL----- ---------C TALLKDDGNN E-SLLLSSVV LNNIIIITKH EELKGAAQQF EIIII----- ---------L SMMMIGGLNN D-DDDDHHGG TAAVVVVYDD GGVYWPPAAD MQQQQGGAAV VVAVDAADGY RMLLIGGLNN N-KDDDHHGG TAAVVVVYNA GGVHWPPDDG LRRRRGGAAI IIKT-KADGY YDFFWWWNNL PEVSWAAAPN NNNN---TII G-LKKDDRGG NIIIHHWDLL LLLLRRRRII YDFFWWWNNL PGVSWTTTPR RRRR---CFF G-FSSEEAGG NLLLHHWDLL LLLLAAAALL YDFFWWWNNL PDYSWAAAPP PPPP---QFF G-IVVAAKGG HLLLHHWDLL LLLLRRRRVV YDFFWWWNNL PDYSWAAAPP PPPP---QFF G-IVVSSKGG HLLLHHWDLL LLLLRRRRVV YDFFWWWNNL PDYSWGGGPP PPPP---QFF G-IVVSSKGG HIIIHHWKLL LLLLRRRRVV YDGGWWWHHL GDTSWGGGPD DDDD---MVV G-LVVGGRGG RLLLHHWDLL LLLLTTTTLL YDFFWWWHHL GDTSWGGGPR RRRR---MVV G-VLLAAKGG HLLLHHWDLL LLLLYYYYLL YDFFWWWHHL GDTSWGGGPN NNNN---MII G-LDDNNGGG RLLLHHWDLL LLLLRRRRLL YDFFWYYQQP RNVTWAAAPN NNNN---VFF GFNPP--LGG SIIIFFWDWW WWWWQQQQII YDFFWYYQQP RNITWAAAPN NNNN---VFF GFNPP--LGG SIIIHHWDWW WWWWQQQQII YDFFWYYQQP RNVTWAAAPN NNNN---VFF GFNPP--LGG SLLLHHWDWW WWWWQQQQII YDFFWYYQQP RNVTWAAAPN NNNN---VLL GFNPP--LGG SLLLYYWDWW WWWWQQQQVV YDFFWYYQQP RNVTWAAAPN NNNN---VLL GFNPP--LGG SLLLYYWDWW WWWWQQQQVV YDFFWYYQQP RNVTWAAAPN NNNN---VLL GFNPP--LGG SLLLYYWDWW WWWWQQQQVV YDFFWYYQQP RNVTWAAAPN NNNN---VLL GFNPP--LGG SLLLYYWDWW WWWWQQQQVV YDFFWYYQQP RNVTWAAAPN NNNN---VLL GFNPP--LGG SLLLYYWDWW WWWWQQQQVV YDFFWYYQQP RNVTWAAAPN NNNN---VVV GFNPP--LGG KLLLHHWDWW WWWWQQQQVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---ASAAASN NNNN---LRR GSRDD--RAA GTTT------ ---------- RTHHLYYEEN AGLWQCCCSL LLLL---FYY GAELL--GHH VSSSCCDNYY YYYYIIIIDD YDFFWYYQQP RNVTWGGGPK KKKK---AFF GFKMM--MGG HLLLNNWDWW WWWWTTTTII YDFFWYYQQP RNVTWGGGPK KKKK---AFF GFKMM--HGG HLLLNNWDWW WWWWTTTTVV YDFFWYYQQP RNTTWGGGPT TTTT---AFF GFDLL--LGG RLLLTTIQLL LLLLAAAARR YDFFWYYQQP RNTTWGGGPK KKKK---AFF GFNLL--LGG RLLLHHYSWW WWWWPPPPKK YDFFWYYQQP RKTTWGGGPK KKKK---AFF GFDLL--LGG SLLLHHYSWW WWWWPPPPKK YHFFWYYQQP RKTTWGGGPK KKKK---AFF GFNLL--LGG SLLLHHYSWW WWWWPPPPKK YDYYWYYQQP RKTSWGGGPA AAAA---AFF GFDLL--LGG RLLLHHYDWW WWWWPPPPKK YDFFWYYQQP RNVTWGGGPN NNNN---HII GFNPP--LGG NVVVHHFEWW WWWWDDDDLL YDFFWYYQQP RNITWGGGPN NNNN---HII GFNPP--LGG NVVVHHFEWW WWWWDDDDLL ---------- ---IRGGGPV VVVV---TVV DEELL--LII KKKKRRY--- ---------- YDYYWYYQQP HNVSWGGGPK KKKK---LFF GYHPPRRQGG CLLLNNYRWW WWWWQQQQFF YDFFWYYQQP YDVSWGGGPN NNNN---KWW GWKNNMMQGG CLLLNNYKWW WWWWSSSSYY LSNNHNNNNG -EKDPDDDPI IIII---MAA SSESSGGLPP QVVVAAVL-- ---------- YDIIRAALLI RNVSFTTTWS SSSSNNYMMM GQMLLMMRGG NIIIVVWDLL LLLLHHHHKK YDVVRAALLP RNLSFTTTWN NNNNNNYMMM GKMLLMMHGG NVVVVVWDLL LLLLHHHHKK HSSLTLGGGM ------LHPP KKGINMVKLL SIIWWLLWFF YYEEDDDKWA AEKKKVIEII YAAIDLGGGM ------LHPP KKGVNVLKLL SIIWWLLWFF YYEEDDDKWA AERRRVIDII QTTIDLGGGM ------AHPP RRGVGVVTLL SIIWWTTWWW RREEGGGKFV VKKKKTATII QTTIDLGGGM ------AHPP RRGVGVVTLL SIIWWTTWWW RREEGGGKFA AEKKKTATII QTTIDLGGGM ------AHPP KKGCGVVTLL AIIFFTTWWW QQDDDDDTFA AKKKKTITII QEEIDFGGGL ------AHPP KKGVNCIKLL SIIWWTTWYY RRDDKKKKWV VRKKKVIEII QTTLDLGGGM ------AHPP KKGMNCVKLL SIIWWLLWYY RRDDNNNSWL LKKKKVIDII QAALDVGGGM ------AHPP RRGVGVVELL SVVWWLLWHH RRQQNNNSWI IRKKKVIEII QTTLQMTTTL ------LHPP AAGVGCLNQQ YKKNNEEEGG ---------- ------TWSS QTTLQMKKKL ------LHPP AAGVGCLNQQ YKKNNEEGGG ---------- ------TWSS QTTLTLQQQL ------LHPP AAGVGCLTQQ YKKNNQQGGG ---------- ------TWSS QTTLPLQQQL ------LHPP AAGVGCLTQQ FKKNNEEDGG ---------- ------TWSS QTTLSLKKKL ------LHPP AAGVGCLTQQ YKKNNEEGGG ---------- ------TWSS QTTLSLKKKL ------LHPP AAGVGCLTQQ YKKNNEEGGG ---------- ------TWSS QTTLSLKKKL ------LHPP AAGVGCLTQQ YKKNNEEGGG ---------- ------TWSS QTTLSLKKKL ------LHPP AAGVGCLTQQ YKKNNEEGGG ---------- ------TWSS QTTLLMPPPH ------LHPP AAGVGCLTQQ YKKNNEEGGG ---------- ------TWSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ESSLPLQQQA NNNNNPIHKK IIDDVVVSRR SDDPPDDAYY ---------- ------AVVV QTTIDLGGGL ------LHPP AAGVGCLTFF YKKEEKKDGG ---------- ------KWAA QTTIDLGGGL ------LHPP AAGVGCLSFF YKKEEKKDGG ---------- ------KWAA QTTLDLGGGL ------LHPP KKGVGSLNII FKKTTQQDGG ---------- ------SWSS QTTLDLGGGL ------LHPP KKGVGSLNII FKKTTQQDGG ---------- ------SWNN QLLIDLGGGL ------LHPP KKGVGSLNII FKKNNSSDDD ---------- ------TWSS QLLIDLGGGL ------LHPP KKGVGSLNII FKKNNSSDEE ---------- ------TWSS QTTLDLGGGL ------LHPP KKGVGCLNVV FKKTTAADGG ---------- ------SWSS QTTIDLPPPA ------LHPP SSAVGCLGFF HPPVVEEENN SS-------- --TTT-THAA QTTIDLPPPA ------LHPP SSAVGCLAFF HPPDDEEKNN PP-------- --KKK-VQTT ---------- ---------- ---------- ---------- ---------- ---------- QTTIDLGGGL ------LHPP EEGVGCFXXX X--------- ---------- ---------- QTTIDLGGGI ------LHPP KKGVGCLKFF KKKKKSSDSS DD-------- --EEEFEAKK ---------- ---------- ---------- ---------- ---------- ---------- KVVFNVPPP- ------PWSS AAASTTLQWW YEEDDDDAGG ---------- ---------- KVVFDVPPP- ------AWEE HHCTSTLQWW YEEDDGGEGG ---------- ---------- IAEEPPLL-- EEIILPVVVV TTDIDDDIIS LDFYYYLWWE RQQNNNNNPP VVVTTGGGKL IAQQPPFF-- PPVVLDVVVV TTDIDDDIIS LDFYYYLWWE RQQNNNNNPP RRRAAGGGRI IAEEPPAADD PPLLLGVVVV TTDIDDDLLS LDFYYYCWWE RQQDDDDDPP VVVAAGGGSI IPEEPPAAEE PPLLLGVVVV TTDIDDDLLS MDFYYYCWWE RQQDDDDDPP KKKAAGGGSI IPVVPPAADD DDLLLGVVVV TTDIDDDLLS LDYYYYCWWE HQQDDDDDPP VVVTTGGGKI IAEEAAAADD PPVVLGVVVV TTDIDDDLLS MDFYYYCWWD LQQDDDDDPP KKKTTGGGKI IAEEPPAADD PPIILPVVVV TTDINNNLLS VDFYYYCWWE HQQDDDDDPP RRRTTGGGKI IAEEPPAADD PPLLLDVVVV TTDINNNLLS LDFYYYCWWE RQQDDDDDPP RRRTTGGGSL SEKKVVIIPP VVKKGMIIII TTDILLLLLS LDFYYYNWWD RQQNNNNNPP RRRTTGGGQL SEKKVVIIPP VVKKGMIIII TTDILLLLLS LDFYYYNWWD RQQNNNNNPP RRRTTGGGQL SEKKVVIIPP VVKKGMIIII TTDILLLLLS LDFYYYNWWD RQQDDDDDPP RRRTTGGGQL SQKKVVIIPP VVKKGMIIII TTDILLLLLS LDFYYYNWWD RQQDDDDDPP RRRTTGGGQL SEKKVVIIPP VVKKGLIIII TTDILLLLLS LDFYYYNWWD RQQDDDDDPP RRRTTGGGQL SEKKVVIIPP VVKKGLIIII TTDILLLLLS LDFYYYNWWD RQQDDDDDPP RRR------- SEKKVVIIPP VVKKGLIIII TT-------- ---------- ---------- ---------- SEKKVVIIPP VVKKGLIIII TTDILLLLLS LDFYYYNWWD RQQDDDDDPP RRRTTGGGQL SEKKVVIIPP VVKKGMIIII TTDILLLLLS LDFYYYNWWD RQQDDDDDPP RRRVVGGGQL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VKRRKKLLYY VVAAKGFFFF PPPAWWWIIF FDLIIIS--- ---------- ---------- AEKKVVIIPP VVEEGAIIII TTDILLLIIS LDFYYYNWWD RQQDDDDDPP KKKVVGGGQL AEKKVVIIPP VVEEGPIIII TTDILLLIIS LDFYYYNWWD RQQDDDDDTT KKKVVGGGQL SELLAAIIKK VVQQNIIIII TTDFLLLIIS LDFYYYNWWD RQQDDDDDLL VVVTTGGGQV NEIIVVIIEE VVQQNFIIII TTDFLLLIIS LDFYYYNWWD RQQDDDDDVV KKKTTGGGQA SEIIVVIIKK VVEENIIIII TTDFLLLIIS LDFYYYNWWD RQQDDDDDPP VVVTTGGGQV SEVVVVIIKK VVEENIIIII TTDFLLLIIS LDFYYYNWWD RQQDDDDDPP VVVTTGGGQV SEVVAAIIKK VVRRNIIIII TTDFVVVIIS LDYYYYNWWD RQQDDDDDPP VVVAAGGGQA ATLLVVAAPP VVSSGAIIII TTDILLLIIS MDFYYYCWWD RQQDDDDDPP KKKNNSSSQI TSLLVVAAPP VVEENAIIII TTDILLLIIS MDFYYYCWWD RQQDDDDDPP KKKNNSSSQI ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGEENEMMMM TTDILLLIIS LDYYYYNWWD RQQDDDDDRR RRRTTGGGQL KVIIDDIIKK TTGGSVIIII SSDIIIIIIS LDFYYYCWWD RQQDDDDDPP KKKTTGGGQL ---------- ---------- ---------- ---------- ---------- ---------- --------QQ VVAADGPPPP VVDISSSIIA ADTWWWSFFK RLLDDDDDPP FFFIIYYYEI --------QQ VVAADGPPPP VVDISSSIIS NDRWWWTFFK RLLDDDDDPP RRRVVYYYEI LGIIHHHRHH PP-------- ---------- -GHHAAMLEE EIDRRRVTYY STTTWWDDDN IGLLHHHRHH PP-------- ---------- -GAAAAMISS SVDRRRVTYY SSSSWWNNNN IGIIRRRRHH PP-------- ---------- -GRRGGMVEE EIDRRRVTYY STTTWWDDDD IGIIRRRRHH PP-------- ---------- -GKKGGMVEE EIDRRRVTYY STTTWWDDDD IGIIKKKKHH PP-------- ---------- -GKKGGMVEE EIDKRRVTYY STTTWWDDDE IGIISSSRHH PP-------- ---------- ANGGGGMVEE EIDRRRVTYY GAAAVVDDDP IGIIRRRRHH PP-------- ---------- ASAAGGMVEE EIDRRRVTYY RAAAWWDDDE LGIIRRRKHH PP-------- ---------- -SGGGGMVEE EVDRRRVSYY ASSSWWDDDE LGSSVVVRSS VVVVLLEE-D QQELQPPLLV VGKKGGMIQQ QLDKRRLTYY SDDDWWDDDK LGSSVVVKSS VVVVLLEE-D QQELQPPLLV VGKKGGMIQQ QLDKRRLTYY SAAAWWDDDK LGSSVVVKPP VVVVLLEE-D QQELQPPLLV VGKKGGMIQQ QLDKRRLTYY SAAAWWDDDK LGSSVVVKPP VVVVLLDD-D QQELQPPLLV VGKKGGMIQQ QLDKRRLTYY SAAAWWDDDK LGSSVVVKPP VVVVLLEE-D QQELQPPLLV VGKKGGMIQQ QLDKRRLTYY SAAAWWDDDK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGSSVVVKPP VVVVLLEE-D EEELQPPLLV VGKKGGMIQQ QLDKRRLTYY SAAAWWDDDK LGSSVVVKPP VVVVLLEE-D QQELQPPLLV VGKKGGMIQQ QLDKRRITYY SDDDWWDDDK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGSSLLLRPP VVVVLLEE-D KKDLQPPVVI VGKKGGMIQQ QLDKRRLTYY SKKKWWDDDK LGSSQQQRPP VVVVLLEE-D KKELQPPVVT VGKKGGMIQQ QLDKRRITYY SIIIWWDDDK VGLLQQQKPP VVAAIIGG-E DDGKQSVPPE IGQQGGMIQQ QLDKRRLTFF SAAAWWDDDK AGLLQQQKPP VVAAVVKK-D DDGEQSVPPE IGKKGGMIQQ QLDKRRLTFF SAAAWWDDDK VGLLQQQKPP VVAAVVGG-E DDGNQFVPPQ IGKKGGMIQQ QLDKRRLTFF SAAAWWDDDR VGLLQQQKPP VVAAVVGG-E DDGNQFVPPQ IGKKGGMIQQ QLDKRRLTFF SAAAWWVVVV AGLLQQQKEE VVYYVVTT-E DDDKQYVPPQ VGHHGGMIQQ QLDKRRITFF SRRRWWDDDE IGSSHHHTNN VVVVLLEE-G EEK-PIALLY VGRRGGMLQQ QLDKRRLTYY KKKKWWDDDD IGSSHHHSTT VVVVLLEE-E DDHDEIALLY VGRRGGMLQQ QLDKRRLSYY KKKKWWDDDD ---------- ---------- ---------- ----GGKIQQ QLDKRRLTYY STTTWWDDDK LGAAQQQRPP RRVVLLNN-D PPELAPPVVF LGRRGGMLQQ QLDRRRLSFF SPPPWWDDDK LGAACCCSPP NNIIVVKKED KKELRPARRY VGRRGGMLQQ QLDKRRLSYY SPPPWWDDDK ---------- ---------- ---------- ---------- ---------- ---------- IRQQNNN--- ---------- ---------- ------MVSS SQDKRRVSLL ANNNWWDDD- IAQQNNN--- ---------- ---------- ------MVSS SSDQRRLTLL ANNNWWDDD- NEELLLGGWM VKAN-----P PSSKEEFFEE --AARRSSSQ RRRGGGASSS SSDDYYCCCY N--LLLGGWM AKVN-----P PEEKEEFFRR --AARRAAAQ RRRGGGASSS TTDDFFCCCY DDDVVVAAAQ VLAG-----P PDDDDDWFDD G-YYRRAAAQ RRRGGGCSSS TTDDFFCCCY DDDVVVGGVE VMVG-----G GNNKDDFFDD G-YYRRAAAQ RRRGGGCSSS TTDDFFCCCY EGGRRRAAAM VMVG-----E ENNKDDWFAA G-YYRRSSSQ RRRGGGCSSS TTDDFFCCCY PEEIIIGGWM VKAG-----P PNNPKKFWKK G-HHRRPPPQ RRRGGGCSSS SSDDYYCCCY EDDIIIGGWM VKVN-----P PDDPNNFFEE --QQRRVVVQ RRRGGGASSS SSDDYYCCCF EVVIIIGGWI AKAD-----P PGGPGGFVDD G-LLRRPPPQ RRRGGGSSSS SSDDYYCCCY KPPLLLRREG SVQVDVVVTV VNNPNNLFKK EGAALLAAAE RRRGGGCSSS SSDDWWIII- KPPLLLRREG SVQIDVVVTA ANNPNNLFKK EGAALLAAAE RRRGGGCSSS SSDDWWIII- KPPLLLRREG SVQIDVVVTV VKKPNNLFKK EGAALLAAAE RRRGGGCSSS SSDDWWLLL- KPPLLLRREG SVQIDVVVTV VKKPNNLFKK EGAALLAAAE RRRGGGCSSS SSDDWWLLL- KPPLLLRREG SVQVDVVVTV VKKPNNLFKK EGAALLAAAE RRRGGGCSSS SSDDWWIII- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KPPLLLRREG SVQVDVVVTV VKKPNNLFKK EGAALLAAAE RRRGGGCSSS SSDDWWIII- KPPLLLRREG SVQIDVVVTV VKKPNNLFKK EGAALLAAAE RRRGGGCTTT SSDDWWLLL- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KPPMMMKKEG SVQIDVVVTE EKKPNNLFKK EGVVLLAAAE RRRGGGCSSS SSDDWWVVV- KPPLLLKKEG AVQIDVVVTK KKKPNNLFKK EGVVLLAAAE RRRGGGCTTT SSDDWWIII- KPPLLLEEKG SHQIDVVVTE EKKPNNFFAA EGAALLAAAE RRRGGGCTTT SSDDWWIII- KPPLLLEEQG SHQIDVVVTE ENNPNNFFAA EGSSLLAAAE RRRGGGCTTT SSDDWWIII- RPPLLLDDKG SHQIDVVVTE EKKPNNFFDD EGAALLAAAE RRRGGGCTTT SSDDWWIII- VPPIIIEEKG SHQIDGGGTE EKKPDDFFDD EGSSLLAAAE RRRGGGCTTT SSDDWWIII- EQQLLLKKKG SHQIDVVVTE EKKPNNFFAA EGSSLLAAAE RRRGGGCTTT SSDDWWIII- DPPHHHKKSG ATQVNIIIPE ESSRDDLFKK IGYYLLAAAE RRRGGGCTTT SSDDWWIII- DPPNNNRRSG ATQIDVVVPI ITTKNNLFKK VGYYLLAAAE RRRGGGCTTT SSDDWWIII- KPPVVVKKEG SVQIDVVVTE EKKKNNLFKK EGCCLLAAAD RRRCGGSTTT SSDDLLAAA- KPPMMMAAAG GTQLDIIIVE ENNENNLFGG EGGGLLPPPE RRR------- ---------- KPPMMMSSQG GHLIDVVVTV VNNEDDLFNN EGSSLLPPPE RRRGGGCTTT SSDDWWLLLA ---------- ---------- ---------- ---------- ---------- ---------- ------KKKG KDQYLKKKYN NWWEDDAFEE LG--RRAAAI RRRSSSLYYY SSSS------ ------KKKG KDQFLKKKYY YWWEQQAFAA EG--RRPPPQ RRRARRLYYY AAGGAAGGGD P------ P------ PSVKRR- PSV---- PSV---- P------ P------ PS----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- NDA---- ------- ------- GNRLVVR 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNKKKKQQPP SSSSEPCCRR VAAARRRADD DGGAMMQQSL LPPTTALTTT GSSSPPVIIK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KAYEEAWSAQ QQVVVLLLAA SSREGRKKTT RSVVLLVVVA QQVVQQAAAV QWHHHWLLPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMMGLLGE ---------- ---------- ---------- ---------- ---------- -LKKKNSSQC ---------- ---------- ---------- ---------- ---------- ---------- --MGGRALPN NNNNNRRRTT PPHNAPAASS PPHHVVRRRP RRTTPPPRRL PCPPPHAARS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMKR ---------- ---------- ---------- ---------- ---------- ------MMKF ---------- ---------- ---AAIVPDY PSSPKKAKAA PEDLLAAVVC YGGGDDDFII ---------- ---------- -----MAKDY PTTPRRARAA PEDIIAAVVA YGGGDDDFLL ---------- ---------- ------MSDH ASSPEEAQAA AEEFFAATTL SDDDDDDALL ---------- ---------- ------MTDH ASSPKKAEAA AENFFAATTL SDDDDDDALL ---------- ---------- ------MTDY PSSAKKAEGG VEKLLAATTM SDDDDDDGLL ---------- ---------- -----MATDY PSSPRRAKAA PETIIAAVVM DEEEDDDAII ---------- ---------- -----MVTDY PSSPRRAKAA AEKLLAAVVR NMMMDDDAMM ---------- ---------- -----MASDY PSSPKKAQAA RERLLGGVVL DGGGDDDALL ---------- ---------- ---KKCTKGP TPPLEEM-GG REEIIVVLLC YNNNDDDYLL ---------- ---------- ---------- --------GG REEIIVVLLC YNNNDDDYLL GGHGGAAAAI IAAAGLLG-- -AAQQCGKGP SPPLEEM-GG REEIIVVLLC YNNNDDDYLL ---------- ---------- ---------- ------M-GG REEIIIILLC YNNNDDDYLL ---------- ---------- ---KKCGNGS TPPLEEM-GG REEIIVVLLC YNNNDDDYLL RREGGAAFFQ QAAAPMRIAA ASSKKCGNGS TPPLEEM-GG REEIIVVLLC YNNNDDDYLL ---------- ---------- ---KKCGNGS TPPLEEM-GG ---------- ----DDDYLL ---------- ---------- ---KKCGNGS TPPLEEM-GG REEIIVVLLC YNNNDDDYLL EEPGGHHTTP PLLLGQLQEE EDDKKCGDGP TPPQEEM-GG REEIIVVLLC YNNNDDDYLL CCGFFDDQQT THHHYCTVFF FTTKKCGNGS TPPLEEM-GG REEIIVVLLC YNNNDDDYLL ---------- ---------- ---KKCGNGS TPPLEEM-GG REEIIVVLLC YNNNDDDYLL SSVLLQQHHE EAAAVETAAA AAATTCCHGA TPPLEEMKGG REKLLVVVVC YGGGDDDYLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---KKCGSGK SPPLDDM-GG REEIIVVLLC YSSSDDDYLL ---------A ALLLHGVNEE EKKVVNGCGA SPPIEEM-GG RESLLIIVVA YGGGDDDYLL ---------G GLLLHAVSEE EKKQQQGCGA SPPLEEM-GG RETLLIIVVA YGGGDDDYLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----RMLGA TPPLAAM-GG SEKLLIIVVA YGGGDDDYLL ---------- ------MAAA AAAAACCGGA TPPLEEMKGG REKLLLLVVC YGGGDDDYLL ---------- -------SPP PNNKKCHGGA SPPADDI-GG REEVVLLVVA ----DDDAII ---------- -------P-- ---KKCHGGA SPPADDI-GG REEVVLLVVA ----DDDAII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---SSESKGA TPPLDDVNGG VEKLLLLVVC QNNNDDDYLL ---------- ---------- ---------- ------MSGG REKLLLLTTT QNNNDDDYLL ---------- ---------- --------MI T---DDLSLL DRFLLYYSSW HDDDTTTDRR RRFGG----- ----ALAG-- -AAGGLPFAC QSSPYYPITT QEEFFVVVVT GEEEDDDKLL FFVSSGGPPH HLLLALVGLL LAAAAAPAAC ASSPYYKITT QEDYYVVVVT GEEEDDDKLL AAAVDDVKKK EESKKHKKEE LLPYIINLHH GGCSSSLL-- PPNNKPNIEE RFFLVVVGSI AAAVDDVKKK PPGKKYKKDD LLPYIIGLHH GGCSSSYY-- PPNNKPFLEE RYYLVVVASI AAAVDDVGGG SSGKKHTTTT MMPNTTGFHH GGCSSSLL-- PPLLHAFLEE RFFLIIIGSI AAAVDDVGGG PPGQQHTTTT MMPNKKGFHH GGCSSSLL-- PPLLHAFIEE RYYLIIIGSI AAAVDDVTTT EEGQQHQQII MMPNKKGFHH GGCSSSLL-- PPLLHAFLEE RYYLIIIGSI AAAVDDVAAA PPASSGQQAA MMPHAAGLHH GGCSSSLL-- PPNNHPHMEE RYYLVVVGSI CCCVDDVQQQ SSGQQGVVDD MMPYTTGLHH GGCSSSLL-- PPNNHPHVEE RYYLVVVDSI GGGVDDLDDD GGAQQGRREE MMPNAAALHH GGCSSALL-- PPYYHPHVEE RYYLVVVGSI AAATDDVKKK PPSQQHRRPP MMPYLLKLHH GGCSSS---- ----DSTKSS RKKLLLLGSI AAATDDVKKK PPSQQHRRPP MMPHLLKLHH GGCSSS---- ----DSTKSS RKKLLLLSSI AAATDDIKKK PPCQQHRRPP MMPNLLRLHH GGCSSS---- ----DSTKSS RKKLLLLCSI AAATDDVKKK PPCQQHRRPP MMPHLLKLHH GGCSSS---- ----DITKAA RKKLLLLASI AAATDDVKKK PPCQQHRRPP MMPNLLKLHH GGCSSS---- ----DSTKSS RKKLLLLSSI AAATDDVKKK PPCQQE---- ---------- ---------- ---------- ---------- AAATDDVKKK PPCQQHRRPP MMPNLLKLHH GGCSSS---- ----DSTKSS RKKLLLLSSI AAATDDVKKK PPCQQHRRPP MMPNLLKLHH GGCSSS---- ----DSTKSS RKKLLLLSSI AAATDDVKKK PPSQQHRRPP MMPYLLKLHH GGCSSS---- ----DSTKSS RKKLLLLSSI AAATDDVKKK PPCQQHRRPP MMPNLLKLHH GGCSSS---- ----DSTKSS RKKLLLLS-- AAATDDVKKK PPCQQHRRPP MMPNLLKLHH GGCSSS---- ----DSTKSS RKKLLLLSSI AAATDDLSSS PPSQQHRRPP VVIHIIGLHH GGCSSS---- ----DPSAKK RFFLLLLSGV ---------- ---------- MMPNTTNLHH GGCSSS---- ----DASKVV RKKLLLLCSI AAATDDVKKK PPSQQHRRPP MMPNVVNLHH GGCSSS---- ----DSSKVV RKKLLLLCSI AAATDDVSSS PPSKKHRRPP VVPYVVGLHH GGCSSS---- ----DPSAEE RFFLAAASGI AAATDDLNNN PPSKKHRRPP VVPYVVGLHH GGCSSS---- ----DPSAQQ RFFLVVVGGV ---------- ---------- MMPFVVGLHH GGCSSS---- ----DASADD RYYLLLLSGI AAATDDVSSS PPSSSHRRPP MMPFVVGLHH GGCSSS---- ----DASVDD RYYLLLLSGI GGGTDDVNNN PPSQQHRRPP VVTHVVGLHH GGCSSS---- ----DPSASS RFFLLLLSGV FFFTDDVEEE DDCQQSRRDD VVPHIIGVHH GGCSSS---- ----KPTEKK RHHLVVVCDI FFFTNNVEEE EECQQSRRDD VVPNIIGVHH GGCSSS---- ----KPTEKK RHHLVVVCDI ---------- ---------- ---------- ---------- ---------- ---MPPPKGE AAATDDVAAA PPCQQHRRYY TTNSKKHLHH GGCSSSHHVV PP--KEVPTT RRRLLLLCDI SSSTDDVEEE PPCQQHRRFF TTNRKKGLHH GGCSSSYYVV DDEEKTVPKK RRRLLLLSDI KKKNRRMQQQ FFGSSKDDPP VVKVLLEELL QQRIIL---- ----KRVQGG GQQMQQQSKL VVVTDDLGGG AAGQQNSSSS VVGG--RAHH GG-------- --------DD RFFFTTTGNI VVVTDDAKKK PPGKKNTTSS VVGG--RAHH DD-------- --------DD RYYLAAAGSI YIIIDDTPNR REEPPKKKKK VVIIPPEKSR LLVGIIIYIS ALGN-EGGIL DHYSELLGWW YIIIDDTPDR RRRPPAAAKK IIVVPPEGTK YYVGIIIYIS ALGG-EGGIF DHDTEIIGWW YVVVDDTPHT TQQAARRRKK IIIIPPDASR PPVGIIIYVS TLGGKDGGIF DCETDLLGWW YIIIDDTPDT TKKAAKKKKK IIIIPPEKSR PPIGIIIYVS TLGGKNGGVF DCETELLGWW YIIIDDV-EL LKKAAKKKKK IIIIPPEASR PPIGIIIYVS TLGGEDGGIF DCETELLGYY YIIIDDTPDL LKKPPFFFKK VVIIPPEESR PPVGIIIYVT ALGN-KGGIA DAQSELLGWW TIIIDDTPDT TQQPPKKKKK VVIIPPNEAR PPVGIIIYIS ALGS-EGGIF DHDNELLGWW HIIIDDTPDR REEPPRRRKK VVIIPPERSR PPIGVVVYVS ALGS-DGGVF DHESDLLGWW YVVVDDVSER RAAPPKKKKK VVIIAASASN TTSLEEEVMV NTLG-NGSFV DGETEKKGWW YVVVDDVSER RAAPPKKKKK VVIIPPNAGN LLSLEEEVMI SSLG-NGGFV DGETEKKGWW YVVVDDVSDR RAAPPKKKKK VVIIAAEAGY VVSLEEEVMI STLG-NGGFV DGETEKKGWW YVVVDDVTER RAAPPKKKKK VVIIPPKTGF FFSLEEEVMV STLG-NGGFV DGKTEKKGWW YVVVDDVSER RAAPPKKKKK VVIIPPEAAF LLSLEEEVMI SSLG-NGGFV DGETEKKGWW ---------- ---------- ----PPKAAF LLSLEEEVMI SSLG-NGGFV DGETEKKGWW YVVVDDVSER RAAPPKKKKK VVIIPPKAAF LLSLEEEVMI SSLG-NGGFV DGETEKKGWW YVVVDDVSER RAAPPKKKKK VVIIPPKAAF LLSLEEEVMI SSLG-NGGFV DGETEKKGWW YVVVDDVTER RAAPPKKKKK VVIIAAKEGT PPSLEEEVMI STLG-NGGFV DGETEKKGWW ---------- ---------- ---------- ---------- ---------- ---------- YVVVDDVSER RAAPPKKKKK VVIIPPKAAF LLSLEEEVMI SSLG-NGGSL LP-RESSG-- YVVVDDTTDR RTTPPSSSKK VVVVSSEEGF PPSLDDDIMI SCLG-NANGF LDSENKKGGG YVVVDDVTDR RAAPPRRRKK TTVVPPYWAN LLSLEEEIMI SSIG-NGGFV DGETEKKGWW YVVVDDVSDR RAAPPRRRKK TTVVPPYWAN PPSLEEEIMI SSLG-NGGFV DGETEKKGWW YVVVDDTTNR RSSPPSSSKK VVVVPPAQAY PPSLEEELMI SCLG-NANGF LDSDNKKGWW YVVVDDTTNR RAAPPSSSKK VVVVPPETAY PPSLEEEIMI SCIG-NANGF LDSENKKGWW YAAADDTENR RAAPPSSSKK YYVVPPKEAY PPALEEEILV SCLG-NANGF LDSDNKKNWW YAAADDTENR RAAPPSSSKK YYVVPPKDAF PPAREEEILV SCLG-NANGL LDSDNKKNWW YVVVDDTKDR RAAPPAAAKK VVVVAAEEGF PPSLEEEIMI SCLG-NANGF LDSENKKGWW YIIINNVNER RKKIIYYYHH TTIIPPSSSF PPSLNNNIMI STLG-TPNFL DGKTEKKGWW YVVVNNVNER REEIIYYYHH TTIIPPSASF PPSLNNNIMI STLG-SPNFL DGKTEKKGWW GKKKFFVG-- ---------- ---------- ---------- ---------- ---------- FVVVDDTTDR RAAPPKKKKK VVIIGG-KTA PPTLNNNIMI SIMG-NA-DF FDKNEVVGWW YIIIDDVTDR RKKPPEEEKK TTIIGG-KTA PPTLNNNIMI SVMG-YA-DF FDSDNIIGWW YVVVTTSYSW WDDKKQQQPP -------KAI SSAQAAALKQ DGVN-VPNGI SKHEGSSAGG FIIIDDVSDS SNNPPKKKKK TTIITT-DVG PPFLMMMMIT GLSN-GGALV NDDGYAATWW FVVVDDVSDA ARRPPVVVKK TTIIDD-KVG PPLLMMMLIT GLSN-GGALV TNAGYAATWW IDRGDDQ--- ---------- -LLLADWWNN LLPNNLLVSS SEWWVVNN-I IIDDGLEDD- VYRGPPQ--- ---------- -FFFADWWNN LLPSSMMISS SEWWVVRR-F FFEEGFEEEG IDRGPPQ--- ---------- -KKKHDWWNN LLPRRMMVSS SEWWLLPP-F FFNNGIEAAN IDRGPPQ--- ---------- -LLLHDWWNN LLPRRMMVSS SEWWLLPP-F FFNNGIESSN MDRGEEQ--- ---------- -KKKHDWWNN LLPRRMMVSS SEWWLLPP-F FFNNGIESSN VERGPPQ--- ---------- -FFFADWWHH LLGYYLLVSS SEWWTTDD-V VVDDGLDGGA IDRGDDQ--- ---------- -LLLHDWWHH LLGYYLLLSS SEWWTTRR-V VVSSGVDAAG VERGPPQ--- ---------- -LLLADWWHH LLGYYMMVSS SEWWTTNN-I IIGGGLQNNK KPGGAAS--- ---------- -MMMGDYYQQ PPRHHMMVTT TEWWAANN-F FFDDGNH--G KPGGEEA--- ---------- -MMMGDYYQQ PPRHHMMVTT TEWWAANN-F FFDDGNH--G QPGGAAA--- ---------- -MMMGDYYQQ PPRHHMMITT TEWWAANN-F FFDDGND--G QPGGAAA--- ---------- -LLLGDYYQQ PPRHHMMITT TEWWAANN-L LLDDGND--G RPGGAAA--- ---------- -SSSGDYYQQ PPRHHMMITT TEWWAANN-L LLDDGND--G RPGGAAA--- ---------- -LLLGDYYQQ PPRHHMMITT TEWWAANN-L LLDDGND--G RPGGAAA--- ---------- -LLLGDYYQQ PPRHHMMITT TEWWAANN-L LLDDGND--G RPGGAAA--- ---------- -LLLGDYYQQ PPRHHMMITT TEWWAANN-L LLDDGND--G RPGGSSA--- ---------- -MMMGDYYQQ PPRHHMMITT TEWWAANN-V VVNNGND--G ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AA AISSHHNN-R RRTTGRP--S NRLFPPI--- ---------- -KKKETYYEE NNAWWFFWWW WIQQCCLL-Y YYTTGEC--S AEGEAAA--- ---------- -FFFGDYYQQ PPRHHMMITT TEWWAAKK-F FFLLGKE--G VEGESSA--- ---------- -FFFGDYYQQ PPRHHMMITT TEWWAAKK-F FFLLGKD--G KPGHSSP--- ---------- -FFFGDYYQQ PPRHHMMITT TSWWAATT-F FFKKGDH--G KPGHSSP--- ---------- -FFFGDYYQQ PPRHHMMITT TSWWAAKK-F FFQQGNH--G KPGHSSP--- ---------- -FFFGDYYQQ PPRHHMMITT TSWWAAKK-F FFKKGDH--G KPDISSP--- ---------- -YYYGHYYQQ PPRHHMMITT TSWWAAKK-F FFKKGNH--G KPGHSSP--- ---------- -FFFGDYYQQ PPRHHMMISS SSWWAAAA-F FFTTGDH--G ADEKTTV--- ---------- -FFFNDYYQQ PPRRRMMITT TEWWSSNN-I IIKKGNH--G ADGKVVV--- ---------- -FFFNDYYQQ PPRRRMMITT TEWWSSNN-I IIKKGNH--G ---------- ---------- ---------- --------II ILRRGGVV-V VVRRDEC--P RGDRKKA--- ---------- -CCCGDYYQQ PPHFFMMVSS SEWWAAKK-F FFRRGHDRRT KGDKKKA--- ---------- -CCCGDYYQQ PPYFFMMVSS SEWWAANN-W WWRRGKDMMS ASQFEEE--- ---------- -LLLQSNNNN GG-RRSSEDD DRPPEEII-A AAEESELGGP PTADDDMGGA VAGGDDVADG GYYYGDAALL IIRKKMMLSS SSFFGGSSYM MMFFGMDMMK PTDGDDLGGA IKGG--YADG GYYYDDAALL PPRKKLLVSS SSFFGGNNYM MMFFGMDMMK -YYGGNNRIH FFWDLRRKKR HHSSTLEEEE EENNRAAAL- -----EELPL HHPPKLMMMG GYYGGNNKLH VVWDLAAKKR YYAADLQQQE EEHHRVVVL- -----EEVPL HHPPKLMMMG NYYGGHHRLH FFWDLRRAAR QQTTDLAAAQ QQHHQAAAL- -----EEVPA HHPPREYYYG NYYGGHHRLH FFWDLRRAAR QQTTDLAAAN NNHHQAAAL- -----EEVPA HHPPREYYYG NYYGGHHKIH FFWKLRRDDR QQTTDLAAAN NNHHQAAAL- -----EEIPA HHPPKDYYYG AYYGGRRRLH FFWDLTTRRR QQEEDFDDDE EEHHQVVVF- -----EELPA HHPPKAYYYG GYYGGHHRLH VVWDLYYRRR QQTTDLAAAE EEYYQAAAL- -----EELPA HHPPKAYYYG KYYGGRRRLH IIWDLRRRRR QQAADVEEEE EEHHQVVVL- -----EELPA HHPPRTYYYG GYYGGSSRIF VVWDWQQRRH QQTTQM---- --DDGIIIP- ----LEEIFL HHPPATQQQG GYYGGSSHIH VVWDWQQRRH QQTTQM---- --DDGIIIP- ----LEEIFL HHPPATQQQG GYYGGSSHLH VVWDWQQRRH QQTTTL---- --DDGIIIP- ----LEEIFL HHPPAAQQQG GYYGGSSHLY VVWDWQQRRR QQTTPL---- --DDGIIIP- ----LEEIFL HHPPAAQQQG GYYGGSSHLY VVWDWQQHHH QQTTSL---- --DDGIIIP- ----LEEIFL HHPPAAQQQG GYYGGSSHLY VVWDWQQRRH QQTTSL---- --DDGIIIP- ----LEEIFL HHPPAAQQQG GYYGGSSHLY VVWDWQQRRH QQTTSL---- --DDGIIIP- ----LEEIFL HHPPAAQQQG GYYGGSSHLY VVWDWQQRRH QQTTSL---- --DDGIIIP- ----LEEIFL HHPPAAQQQG GYYGGKKHLH VVWDWQQRRH QQTTLM---- --DDGIIIP- ----LEEIFL HHPPASQQQG ---------- ---------- ---------- ---------- ---------- ---------- SVVAAGGIT- ---------- ---------- ---------- ---------- ---------- SVVHHVVISC LLDNYIIMMR EESSPL---- --DDQGGGAN PIIILCCLSI HHKKINQQQD GYYGGHHSLN VVWDWTTEEH QQTTDLEEE- --DDGIIIP- ----LEEIFL HHPPAAQQQG GYYGGHHSLN VVWDWTTEEH QQTTDLKKK- --DDGIIIP- ----LEEIFL HHPPADQQQG GYYGGRRHLT CCIQLAARRG QQTTDLNNN- --TTGLLLP- ----LEEIFL HHPPKDTTTG GYYGGRRHLH VVYSWPPGGG QQTTDLDDD- --KKGLLLP- ----LEEIFL HHPPKDTTTG GYYGGSSHLH VVYSWPPGGG QQLLDLEEE- --TTGLLLP- ----LEEIFL HHPPKDTTTG GYYGGSSHLH VVYSWPPGGG QQLLDLPPP- --TTGLLLP- ----LEEIFL HHPPKDTTTG GYYGGRRHLH VVYDWPPGGG QQTTDLSSS- --TTGLLLP- ----LEEVFL HHPPKDTTTG GYYGGNNSVH IIFEWDDSSK QQTTDLQQQP PPLLGLLLP- ----LEEVFL HHPPSEHHHA GYYGGNNSVH IIFEWDDTTK QQTTDLMMMP PPRRGLLLP- ----LEEVFL HHPPSEHHHA PVVIIKKCKR VVY------- ---------- ---------- ---------- ---------- TYYGGCCRLN FFYRWQQEER QQTTDLDDD- --DDGTTTP- ----LEEIFL HHPPENQQQG SYYGGCCRLN FFYKWSSTTQ QQTTDLSSS- --DDGTTTP- ----LEEIFL HHPPKAEEEG PKKPPQQHVA EEVL------ ---------- ---------- ---------- ---------- KFFGGNNTIV QQWDLHHTTR KKVVNVGGGA AAPP------ ----LEEIFP WWSSANYYYA KFFGGNNTVV TTWDLHHTTK KKVVDVGGGA AAPP------ ----LEEICA WWEEHNYYYC GFNVSKKKKK KKDLSSSSWW FF-EEEEDKN AEKVEIIIIE PPEEG-NLLE IILKKPPPKA GFNLNKKKKK KKDLSSSSWW FF-EEEEDKQ AERVDIIIIQ PPEEG-PLLP VVLKKDDDKM GFGVDTTTTT TTNLEGGSWW WW-EEEEGKH VKKTTIIIIE PPTTADELLP LLLQQGGGGA GFGVDTTTTT TTNLEAASWW WW-EEEEGKH AEKTTIIIIE PPPPKEKLLP LLLQQGGGGA GFGVDTTTTT TTNLQGGAFW WWKDDDDDTE AKKTTIIIIV PPDDADDLLD LLLKKGGGGA GFNISKKKKK KKDLSSSSWW YY-DDDDKKA VRKVEIIIIE AADDPDQLLP VVLKKGGGKA GFNVSKKKKK KKDLSAASWW YY-DDDDNSH LKKVDIIIIE PPSSEDQLLP IILKKPPPKA GFGVSEEEEE EEDLSAASWW HH-QQQQNSG IRKVEIIIIE PPEEPDQLLP LLLKKDDDGA GFGLSNNNNN NNIQRFFYNE GG-------- ----WSSSSK VVQQVPSKKV KKGWWMMMPE GFGLSNNNNN NNIQRFFYNG GG-------- ----WSSSSK VVQQVPSKKV KKGWWMMMPE GFGLSTTTTT TTIQRFFYNG GG-------- ----WSSSSK VVQQVPPKKV KKGWWMMMPE GFGLSTTTTT TTIQRFFFND GG-------- ----WSSSSK VVQQVPPKKV KKGWWMMMPE GFGLSTTTTT TTIQRFFYNG GG-------- ----WSSSSK VVQQVPPKKV KKGWWLLLPE GFGLSTTTTT TTIQRFFYNG GG-------- ----WSSSSK VVQQVPPKKV KKGWWLLLPE GFGLSTTTTT TTIQRFFYNG GG-------- ----WSSSSK VVQQVPPKKV KKGWWLLLPE GFGLSTTTTT TTIQRFFYNG GG-------- ----WSSSSK VVQQVPPKKV KKGWWLLLPE GFGLSTTTTT TTIQRFFYNG GG-------- ----WSSSSK VVEEVPPKKV KKGWWMMMPE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DYVVSSSSSS SSGRGGGSPA YY-------- ----VVVVVR KKDDLYYAAV AAKFFGGGVS GLGLSTTTTT TTVFRFFYED GG-------- ----WAAAAK VVKKVPSKKV EEGWWAAAPE GLGLSSSSSS SSIFRFFYED GG-------- ----WAAAAK VVQQVPSKKV EEGWWPPPPE GFGLSNNNNN NNMIRFFFTD GG-------- ----WSSSSL AAPPVKPLLV QQNWWIIIPE GFGLTNNNNN NNMIRFFFTD GG-------- ----WNNNNI VVSSVEPLLV QQNWWFFFPE GYGLSNNNNN NNMIRFFFND DD-------- ----WSSSSI VVSSVKPLLV EENWWIIIPE GFGLSNNNNN NNMIRFFFND EE-------- ----WSSSSV VVSSVKPLLV EENWWIIIPE GYGLTNNNNN NNMVRFFFTD GG-------- ----WSSSSV AASSIKPLLV RRNWWIIIPE AFGLGGGGGG GGIFRIIHVE NN-------- --T-HAAAAL VVFFIPSKKV SSGWWAAAPE AFGLGAAAAA AAIFRIIHDK NN-------- --K-QTTTTL VVTTIPSKKV EENWWAAAPD ---------- ---------- ---------- ---------- ---------- ---------- GYGFXXXXXX XXXXXXXX-- ---------- ---------- ---------G EENGGEEEEM GFGLNKKKKK KKVFHFFKKD SS-------- --EFAKKKKI DDPPGKLVVT GGSGGVVVED ---------- ---------- ---------- ---------- ---------- ---------- AFTLTQQQQQ QQLWLIIYDA GG-------- ---------- --EEWQAKKV AADIIGGGPA CFSLTQQQQQ QQLWLIIYDE GG-------- ---------- --EEWQAKKV AADIIGGGPA VPPPPLDDDI IIIDDDDKFF LLYYLLLLLG GVRRRRRYYD DDINNPFFPP LTKGIIIFF- VPPPPLDDDI IIIDDDDRFF LLYYVVVLLG GLRRRRRYYD DDINNPHHPP LAKGLLLYY- VPPPPLDDDI LLLDDDDRFF LLYYVVVCCG GMRRRRRYYD DDVDDPHHPP LARGIIIAA- VPPPPLDDDI LLLDDDDRFF LLYYVVVCCG GMRRRRRYYD DDVDDPRRPP LAHGIIIAA- CPPPPLDDDI LLLDDDDKYY LLYYVVVCCG GMHHHHHYYD DDVDDPMMPP LTEGIIIVV- VPPPPLDDDI LLLDDDDRFF LLYYVVVCCG GLLLLLLYYD DDVDDPFFPP LTRGIIIVV- VPPPPLDDDI LLLDDDDRFF LLYYVVVCCG GLHHHHHYYD DDVDDPFFPP LTQGIIIVV- VPPPPLDDDI LLLDDDDRFF LLYYVVVCCG GLRRRRRYYD DDVDDPFFPP HTRGIIIVV- MPPPPLDDDI LLLDDDDRFF LLYYFFFNNL GIRRRRRYYD DDINNPQQPP LTFGSSSIIV MPPPPLDDDI LLLDDDDRFF LLYYFFFNNL GIRRRRRYYD DDINNPKKPP LTFGSSSIIV MPPPPLDDDI LLLDDDDRFF LLYYFFFNNL GLRRRRRYYD DDIDDPQQPP LTFGSSSIIV MPPPPLDDDI LLLDDDDHFF LLYYFFFNNL GIRRRRRYYD DDVDDPQQPP LTFGSSSIIV MPPPPLDDDI LLLDDDDRFF LLYYFFFNNL GLRRRRRYYD DDIDDPQQPP LTFGSSSIIV MPPPPLDDDI LLLDDDDRFF LLYYFFFNNL GLRRRRRYYD DDIDDPQQPP L--------- MPPPPL---- ---------- ---------- ---------- ---------- ---------- MPPPPLDDDI LLLDDDDRFF LLYYFFFNNL GLRRRRRYYD DDIDDPQQPP LTFGSSSIIV MPPPPLDDDI LLLDDDDRFF LLYYFFFNNL GMRRRRRYYD DDIDDPKKPP LVFGSSSIIV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LSSSSEPPPA IIISDDDLLL IIIIFFFSS- ---------- ---------- ---------- MPPPPLDDDI IIIDDDDRFF LLYYFFFNNL GIRRRRRYYD DDIDDPRRPP LVFGSSSIIV MPPPPLDDDI IIIDDDDRFF LLYYFFFNNL GIRRRRRYYD DDIDDTRRPP LVFGSSSIIV MPPPPLDDDF IIIDDDDRFF LLYYFFFNNL GIRRRRRYYN NNIDDLKKPP LTWGLLLIIA MPPPPLDDDF IIIDDDDRFF LLYYFFFNNL GIRRRRRYYN NNIDDVKKPP LTWGLLLIIA MPPPPLDDDF IIIDDDDRFF LLYYFFFNNL GIRRRRRYYN NNIDDPKKPP LTWGLLLLLA MPPPPLDDDF IIIDDDDRFF IIYYFFFNNL GIRRRRRYYN NNIDDPKKPP LTWGLLLLLA MPPPPLDDDF IIIDDDDRYY LLYYLLLNNL GIRRRRRYYN NNIDDPAAPP LAWGLLLLLY MPPPPLDDDI IIIDDDDRFF LLYYVVVCCL GIRRRRRYYD DDIDDPLLVV LNYGSSSVVV MPPPPLDDDI IIIDDDDRFF LLYYVVVCCL GIRRRRRYYD DDIDDPKKPP LNFGSSSIIV ---------- ---------- ---------- ---------- ---------- ---------- MGGGGMDDDI IIIDDDDRYY LLYYFFFNNR GVRRRRRYYD DDIDDRAAPP LTFGAAAIIV MGGGGMDDDI IIIDDDDRFF LLYYVVVCCR GVRRRRRYYD DDIDDPEEPP LTFGAAAIII ---------- ---------- ---------- ---------- ---------- ---------- DIIIILDDDI IIIDDDDQTT LLWWIIISSM GTRRRRRFFD DDIDDPHHPP QIVDQQQVV- KVVVVLDDDI IIIDDDDSRR LLWWVVVTTM GTRRRRRFFD DDIDDPHHPP QVTGQQQVV- ---------- AGHHHHKKLL TTGGGALEII RRRDDGRRVV VVSSLYYYSS SSTQQFYPPP ---------- SGAAAAEEAA TTGGGAISVV RRRDDGRRVV VISSLYYYSS SSSQQFYPPP ---------- NGRRRRTTFF AAGGGGVEII RRRDDGRRVV VWSSLYYYSS SSTQQFYPPP ---------- NGKKKKAAFF AAAAAGVEII RRRDDGRRVV VWSSLYYYSS SSTQQFYPPP ---------- NGKKKKTTFF GGYYYGVEII RRRDDGRRVV VWSSLYYYSS SSTQQFYPPP ---------- KNGGGGAALL NNGGGGVEII RRRDDGRRVV VFSSLYYYGG GGAQQFYPPP ---------- TSAAAAEELL NNGGGGVEII RRRDDGRRVV VFSSLYYYRR RRAQQFYPPP ---------- ASGGGGPPLL NNGGGGVEVV RRRDDGRRVV VFSSLYYYAA AASQQFYPPP EDDQLPLLVV KGKKKKRRII PPGGGGIQLL LLLDDGRRLL LASSLYYYSS SSDQQFY--- EDDQLPLLVV KGKKKKRRVV PPGGGGIQLL LLLDDGRRLL LVSSLYYYSS SSAQQFY--- EDDQLPLLVV KGKKKKKKVV PPGGGGIQLL LLLDDGRRLL LVSSLYYYSS SSAQQFY--- DDDQLPLLVV KGKKKKQQVV AAGGGGIQLL LLLDDGRRLL LVSSLYYYSS SSAQQFY--- EDDQLPLLVV KGKKKKRRVV AAGGGGIQLL LLLDDGRRLL LISSLYYYSS SSAQQFY--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EDDELPLLVV KGKKKKRRVV AAGGGGIQLL LLLDDGRRLL LISSLYYYSS SSAQQFY--- EDDQLPLLVV KGKKKKRRVV PPGGGGIQLL LLLDDGRRII IVSSLYYYSS SSDQQFY--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EDDKLPVVII KGKKKKKKVV PPGGGGIQLL LLLDDGRRLL LVSSLYYYSS SSKQQFY--- EDDKLPVVTT KGKKKKIIII PPGGGGIQLL LLLDDGRRII IVSSLYYYSS SSIQQFY--- GEEDKVPPEE QGQQQQKKLL RRGGGGIQLL LLLDDGRRLL LVSSLFFFSS SSAQQFY--- KDDDEVPPEE QGKKKKKKLL RRGGGGIQLL LLLDDGRRLL LVSSLFFFSS SSAQQFY--- GEEDNVPPQQ KGKKKKSSLL RRGGGGIQLL LLLDDGRRLL LASSLFFFSS SSAQQFY--- GEEDNVPPQQ KGKKKKSSLL RRGGGGIQLL LLLDDGRRLL LASSLFFFSS SSASSFY--- TEEDKVPPQQ KGHHHHRRLL RRGGGGIQLL LLLDDGRRII IVSSLFFFSS SSRQQFYGGG EGGE-ALLYY KGRRRRKKII EEGGGGLQLL LLLDDGRRLL LVSSLYYYKK KKKQQFY--- EEEDDALLYY KGRRRRQQII EEGGGGLQLL LLLDDGRRLL LVSSLYYYKK KKKQQFY--- ---------- ---------- --GGGGIQLL VVVDDGRRLL LVSSFYYYSS SSTQQFY--- NDDPLPVVFF KGRRRRRRLL LLGGGGLQLL LLLDDGRRLL LVSSLFFFSS SSPQQFY--- KDDKLARRYY KGRRRRRRLL EEGGGGLQLL LLLDDGRRLL LVSSLYYYSS SSPQQFY--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------VSQQ WWWDDGRRVV VFSSLLLLAA AAN------- ---------- ---------- ------VSSS WWWDDGRRLL LYSSLLLLAA AAN------- EEGGLKKKMV KAN-----SG GLEEEIIEFV FE------RS QVRSDDAAAD DSCCCYPP-- --GGLRRRMA KVN-----EG GLEEELLEFV FR------RA QVRWDDAAAD DSCCCYPP-- DDGGVPPPQV LAG-----DG GLTTTLLDYV FDG-----RA QIREDDCCCD DSCCCYPPSK DDGGVPPPEV MVG-----NG GLEEELLDYV FDG-----RA QIREDDCCCD DSCCCYPPS- GGDDRGGGMV MVG-----NG GLTTTLLDFV FAG-----RS QIREDDCCCD DSCCCYPPS- EEGGIDDDMV KAG-----NG GIEEEFFKFL WKG-----RP QVRQDDCCCD DSCCCYPP-- DDGGIKKKMV KVN-----DG GMQQQFFNFV FE------RV QIRQDDAAAD DSCCCFPP-- VVGGIRRRIA KAD-----GG GLSSSLLGFT VDG-----RP QIREDDSSSD DSCCCYPPS- PPDDLIIIGS VQVVVVVTNG GLKKKLLNFV FKEPPLGPLA ELRPDDCCCD DIIII----- PPNNLIIIGS VQIVVVVTNG GLKKKLLNFV FKEPPLGPLA ELRPDDCCCD DIIII----- PPDDLIIIGS VQIVVVVTKG GLKKKLLNFV FKEPPLGPLA ELRPDDCCCD DILLL----- PPDDLIIIGS VQIVVVVTKG GLTTTLLNFV FKEPPLGPLA ELRPDDCCCD DILLL----- PPDDLIIIGS VQVVVVVTKG GLKKKLLNFV FKEPPLGPLA ELRPDDCCCD DIIII----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPDDLIIIGS VQVVVVVTKG GLKKKLLNFV FKEPPLGPLA ELRPDDCCCD DIIII----- PPDDLIIIGS VQIVVVVTKG GLKKKLLNFV FKEPPLGPLA EIRPDDCCCD DILLL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPDDMIIIGS VQIVVVVTKG GLKKKLLNFV FKEPPGGPLA ELRPDDCCCD DIVVV----- PPDDLLLLGA VQIVVVVTKG GLKKKLLNFV FKEPPDGPLA EIRPDDCCCD DIIII----- PPGGLVVVGS HQIVVVVTKG GLKKKIINFV FAEPPDGPLA EMRPDDCCCD DIIII----- PPKKLVVVGS HQIVVVVTNG GLKKKIINFV FAEPPDGPLA EMRPDDCCCD DIIII----- PPEELMMMGS HQIVVVVTKG GLSSSIINFV FDEPPEGPLA EMRPDDCCCD DIIII----- PPEEIMMMGS HQIGGGGTKG GLTTTIIDFV FDEPPDGPLA EMRPDDCCCD DIIII----- QQDDLVVVGS HQIVVVVTKG GLSSSIINFV FAEPPEGPLA EMRPDDCCCD DIIII----- PPEEHVVVGA TQVIIIIPSG GMEEEIIDFI FKIEEGGPLA EMRPDDCCCD DIIII----- PPEENVVVGA TQIVVVVPTG GMVVVIINFI FKVPPGGPLA EMRPDDCCCD DIIII----- PPNNVVVVGS VQIVVVVTKG GLTTTVVNFV FKEPPNGPLA DIRPDDSSSD DIAAA----- PPEEMVVVGG TQLIIIIVNG GMKKKLLNFV FGEPPYGPLP EMR------- ---------- PPKKMVVVGG HLIVVVVTNG GISSSLLDFV FNEPPYGPLP EMRPDDCCCD DILLLANND- ---------- ---------- ---------- ---------- ---------- ---------- --------GK DQYKKKKYWD DKEEELLDFV FELGGLG-RA IMRGAALLLS S--------- --------GK DQFKKKKYWD DKEEELLQFI FAEKKLG-RP QMRGAALLLG GPGGGDGGNL ------- ------- KK----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLQRVVV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NSAKKKKKPP PSSAAATCRR VVGGLTTTAR AADGMQLLTA QQLLLLTTPV VVVVRRIYQA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -------MAR gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAAFFSSQQV VLASSSSSSE KGGGRRKTRR SVLLVEISSS AAAAVVKVVP PPAAQWLLPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------LLGE ---------- ---------- ---------- ---------- ---------- -----LSSQC ---------- ---------- ---------- ---------- ---------- ---------- RRSTTLPNNN NRTPPTTPPN LAAAPPASPP PHVVPLTLLL VVVVRRYTIN NNPRPCAARS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMKR ---------- ---------- ---------- ---------- ---------- ------MMKF ---------- -------MII VFFFFRRDFY YPSMAMKKAA PPPPELLYAA ACYTGTTTTG ---------- --------MM ALLLLPPDFY YPTDAMRRAA PPPPEIIYAA AAYVGTTTTG ---------- ---------- MMMMMPPDFH HASLAMQQAA PPAAEFFYLL LLSPDFFFFS ---------- ---------- MMMMMPPDFH HASLAMEEAA PPAAEFFYLL LLSPDFFFFS ---------- ---------- MLLLLPPDFY YPSLAMEEGG PPVVELLFLL LMSPDAAAAS ---------- --------MM AWWWWPPDFY YPSLAAKKAA PPPPEIIYAA AMDPERRRRK ---------- --------MM VWWWWPPDFY YPSMAVKKAA PPAAELLYVV VRNPMAAAAN ---------- --------MM AWWWWPPDFY YPSMAMQQAA PPRRELLYAA ALDPGRRRRE ---------- ----AAATCC T----CCGYP PTPAMK--GG PPRREIIYPP PCYRNTTTTG ---------- ---------- ---------- -----M--GG PPRREIIYPP PCYRNTTTTG KHAAAAVAPA GGLPSSSTCC G----CCGYP PSPAMK--GG PPRREIIYPP PCYGNTTTTG ---------- ---------- ---------- ----MK--GG PPRREIIYPP PCYRNTTTTG ---------- ----AAATCC G----CCGYS STPAMK--GG PPRREIIYPP PCYRNTTTTG AEAAFFTSVA PPMPAAATCC G----CCGYS STPAMK--GG PPRREIIYPP PCYRNTTTTG ---------- ----AAATCC G----CCGYS STPAMK--GG ---------- ---------- ---------- ----AAATCC G----CCGYS STPAMK--GG PPRREIIYPP PCYRNTTTTG EPHHTTAWFL GGQWAAATCC G----CCGYP PTPAMK--GG PPRREIIYPP PCYRNTTTTG LGDDQQTELH YYCLPPPTCC G----CCGYS STPAMK--GG PPRREIIYPP PCYRNTTTTG ---------- ----AAATCC G----CCGYS STPAMK--GG PPRREIIYPP PCYRNTTTTG LVQQHHIGAA VVEAGGGKCC CTTTTKKGYA ATPAMEKKGG PPRRELLYTT TCYNGTTTTG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMMACC G----CCGYK KSPAMK--GG PPRREIIYPP PCYRSTTTTG -------TVL HHGVSSS-NN GCCCCSSGYA ASPSMS--GG PPRRELLYTT TAYAGTTTTG -------TVL HHAVNNNNQQ GCCCCSSGYA ASPAMS--GG PPRRELLYTT TAYAGTTTTG ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------RR MQQQQGGGYA ATPAMS--GG PPSSELLYTT TAYTGTTTTG ---------- ---AGGGACC CGGGGTTGYA ATPAMEKKGG PPRRELLYTT TCYNGTTTTG ---------- ---MGGGLCC H------GYA ASPAIK--GG PPRREVVFTT TA---NNNNA ---------- ---MPPPLCC H------GYA ASPAIK--GG PPRREVVFTT TA---HHHHA ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MEE SCCCCCCGYA ATPAVRNNGG PPVVELLYVV VCQPNLLLLD ---------- ---------- ---------- ----MRSSGG PPRRELLYVV VTQPNLLLLD ---------- ---------- -------MLI IT-ILISSLL DDDDRLLFNN NWHGDIIIIR EF-------- AALAAAAMLL PRRRRFFATC CQSMPKIITT GGQQEFFYWW WTGVEGGGGM IVGGPPSFAL AALSAAALAA PGGGGRRATC CASMKKIITT GGQQEYYYWW WTGAEGGGGV IADDFAAVVV VVDNPKSEYY SKVVHELPPI NNNDDLHHHF NNACCSSSSA C-PPNNNGGK VPDDFAAVVV VVDDPKSPYY GKIIYDLPPI GGGDDLHHHF NNACCSSSSA C-PPNNNAAK -PDDAAAIII IIDKPGSSYY GKVVHTMPPT GGGDDFHHHF NNACCSSSSS S-PPLLLTTH -PDDAAAIII IIDKPGSPYY GQVVHTMPPK GGGDDFHHHF NNACCSSSSA S-PPLLLAAH -PDDGAAVVV VVDDPTSEFF GQVVHIMPPK GGGDDFHHHF NNACCSSSSA S-PPLLLTTH -PDDAAAVVV VVDDPASPYY ASVVGAMPPA GGGDDLHHHF NNACCSSSSC C-PPNNNAAH GPDDACCVVV VVDDSQSSFF GQVVGDMPPT GGGGGLHHHF NNACCSSSSM C-PPNNNAAH -PDDAGGLLL LLDDPDSGYY AQVVGEMPPA AAADDLHHHF NNACCSSSSA C-PPYYYAAH TPDDYAAVVV VVDDPKSPYY SQIIHPMPPL KKKDDLHHHS NNTCCSSSSC -------FFD IPDDYAAVVV VVDDPKSPYY SQIIHPMPPL KKKDDLHHHS NNTCCSSSSC -------FFD IPDDYAAVVV VVDDPKSPYY CQIIHPMPPL RRRDDLHHHS NNACCSSSSC -------FFD IPDDYAAVVV VVDDPKSPYY CQIIHPMPPL KKKDDLHHHS NNTCCSSSSC -------YYD TPDDYAAVVV VVDDPKSPYY CQIIHPMPPL KKKDDLHHHS NNTCCSSSSC -------FFD TPDDYAAVVV VVDDPKSPYY CQIIE----- ---------- ---------- ---------- TPDDYAAVVV VVDDPKSPYY CQIIHPMPPL KKKDDLHHHS NNTCCSSSSC -------FFD TPDDYAAVVV VVDDPKSPYY CQIIHPMPPL KKKDDLHHHS NNTCCSSSSC -------FFD TPDDYAAVVV VVDDPKSPYY SQIIHPMPPL KKKDDLHHHS NNTCCSSSSC -------FFD TPDDYAAVVV VVDDPKSPYY CQIIHPMPPL KKKDDLHHHS NNTCCSSSSC -------FFD TPDDYAAVVV VVDDPKSPYY CQIIHPMPPL KKKDDLHHHS NNTCCSSSSC -------FFD ILDDYAAVVV VVDDPSSPYY SQIIHPVIII GGGDDLHHHS NNSCCSSSSC -------HHD ---------- ---------- ------MPPT NNNDDLHHHS NNTCCSSSSC -------YYD IPDDYAAVVV VVDDPKSPYY SQIIHPMPPV NNNDDLHHHS NNTCCSSSSC -------YYD IPDDYAAVVV VVDDPSSPYY SKIIHPVPPV GGGDDLHHHT NNSCCSSSSC -------HHD IPDDYAAVVV VVDDPNSPYY SKIIHPVPPV GGGDDLHHHT NNSCCSSSSC -------HHD ---------- ---------- ------MPPV GGGDDLHHHS NNSCCSSSSC -------HHD IPDDYAAVVV VVDDPSSPYY SSIIHPMPPV GGGDDLHHHS NNSCCSSSSC -------HHD IPDDYGGVVV VVDDPNSPYY SQIIHPVTTV GGGDDLHHHS NNACCSSSSC -------HHD APDDAFFVVV VVDNPESDFF CQIISDVPPI GGGDDVHHHT NNACCSSSSC -------HHK RPDDAFFVVV VVNNPESEFF CQIISDVPPI GGGDDVHHHT NNACCSSSSC -------HHK ---------- ---------- ---------- ---------- ---------- ---------- EGDDYAAVVV VVDDPASPYY CQIIHYTNNK HHHNNLHHHS NNTCCSSSSC FVPP---GGK EGDDYSSVVV VVDDPESPYY CQVVHFTNNK GGGDDLHHHS NNACCSSSSC YVDDEEESSK QITTDKKPPP PPRVGQVFGG GSLLKPVKKL EEEDDELLLS TTPRRIIIIK ---------K GQDDKVVIII IIDRPGSARR GQIINSVGG- RRRNNAHHHG SSA------- ---------- GQDDKVVVVV VVDNPKSPYY GKVVNSVGG- RRRNNAHHHS TTD------- ---------- KPNNNIRFLL VPGSSSSSII YIDDTTKPPP PPKIIVKSSG RLLLHHHHTT TVCGGGPPPA KPFFFLRYLL VPASSSSSII YIDDTTKPKK PPAVAAGTTG KYYYHHHHTT TVCGGGPPPA HAFFFLRFLL IPGSSSSSII YVDDTTKPPP AARIHIATTG RPPPHHHHTT TVCGGGPPPG HAFFFIRYLL IPGSSSSSII YIDDTTKPPP AAKIHVKTTG RPPPHHHHTT TICGGGPPPG HAFFFLRYLL IPGSSSSSII YIDDVVK-PP AAKIHVATTG RPPPHHHHTT TICGGGPPPG HPHHHMRYLL VPGSSSSSII YIDDTTKPPP PPFLALETTG RPPPHHHHTT TVCGGGPPPG HPHHHVRYLL VPDSSSSSII TIDDTTKPPP PPKVVLETTG RPPPHHHHTT TVCGGGPPPG HPHHHVRYLL VPGSSSSSII HIDDTTKPPP PPRIVLRTTG RPPPHHHHTT TICGGGPPPG DSTTTKRKLL LPGSSSSSII YVDDVVGSPP PPKLHIACCN NTTTHHHHTT TSCLLLAAAG DSTTTKRKLL LPSSSSSSII YVDDVVGSPP PPKLHIACCN NLLLHHHHTT TSCLLLAAAG DSTTTKRKLL LPCSSSSSII YVDDVVGSPP PPKLHIACCG YVVVHHHHTT TSCLLLAAAG DITTTKRKLL LPASSSSSII YVDDVVGTPP PPKLHITCCN FFFFHHHHTT TSCLLLPPPG DSTTTKRKLL LPSSSSSSII YVDDVVGSPP PPKLHIACCE FLLLHHHHTT TSCLLLAAAG ---------- ---------- ---------- -----IACCE FLLLHHHHTT TSCLLLAAAG DSTTTKRKLL LPSSSSSSII YVDDVVGSPP PPKLHIACCE FLLLHHHHTT TSCLLLAAAG DSTTTKRKLL LPSSSSSSII YVDDVVGSPP PPKLHIACCE FLLLHHHHTT TSCLLLAAAG DSTTTKRKLL LPSSSSSSII YVDDVVGTPP PPKLHIECCG TPPPHHHHTT TSCLLLPPPG DSTTTKRKLL LPS------- ---------- ---------- ---------- ---------- DSTTTKRKLL LPSSSSSSII YVDDVVGSPP PPKLHIACCE FLLLHHHHTT TSCLLLAAAG DPSSSARFLL LPSSSGGGVV YVDDTTATPP PPSLHIEIIG FPPPHHHHTT TSCLLLAAAG DASSSKRKLL LPCSSSSSII YVDDVVGTPP PPRIHVWCCG NLLLHHHHTT TSCLLLGGGG DSSSSKRKLL LPCSSSSSII YVDDVVGSPP PPRIHVWCCG NPPPHHHHTT TSCLLLGGGG DPSSSARFLL APSSSGGGII YVDDTTKTPP PPSLHIQTTG YPPPHHHHTT TSCLLLAAAG DPSSSARFLL VPGSSGGGVV YVDDTTKTPP PPSLHITTTG YPPPHHHHTT TSCLLLAAAG DASSSARYLL LPSSSGGGII YADDTTKEPP PPSLYIETTG YPPPHHHHTT TACLLLAAAG DASSSVRYLL LPSSSGGGII YADDTTKEPP PPSLYIDTTG FPPPHHHHTT TACRRRTTTG DPSSSARFLL LPSSSGGGVV YVDDTTLKPP PPALHIETTG FPPPHHHHTT TSCLLLAAAG KPTTTERHLL VPCSSDDDII YINNVVEN-- IIYLELSNN- FPPPHHHHTT TSCLLLAAAG KPTTTERHLL VPCSSDDDII YVNNVVEN-- IIYLQLANN- FPPPHHHHTT TSCLLLAAAG --------MM PRKSSGGGEE GKFFVVGG-- ---------- ---------- ---------- KEVVVPRRLL LPCSSDDDII FVDDTTGTPP PPKLAVKAAD APPPHHHHTT TTCLLLPPPG KTVVVPRRLL LPSSSDDDII YIDDVVVTPP PPEIVVKHHN APPPHHHHTT TTCLLLAAAG KRVVVQGQMM QLSGGKKKLL YVTTSSLYAA KKQFYLKLLV ISSSHHHHTT TAYQQQPPPT ------RFFF TGGTTNNNII FIDDVVHSPP PPKLHVDGGG GPPPHHHHTT TFALLLPPPS ------RYLL AGGTTSSSII FVDDVVHSPP PPVLSVKGGG GPPPHHHHTT TLALLLPPPR AYYLGGE--- EEG--EGPGG MLLLDDYSLL WEIIIDRGDQ Y--------- -YYYDWNNLL AYYLGGP--- DDGRREGPGG LLLLDDDTII WEVVVYRGPQ Y--------- -YYYDWNNLL GYYLGGAGGG DDGTTDGAPP IMMMDDETLL WEIIIDRGPQ D--------- -YYYDWNNLL GYYLGGGGGG DDGTTNGPPP IMMMDDETLL WEIIIDRGPQ T--------- -YYYDWNNLL GYYLGGGGGG DDGTTDGPPP ILLLDDETLL YEMMMDRGEQ T--------- -YYYDWNNLL GYYLGGA--- EEG--KGPGG MLLLDDQSLL WEVVVERGPQ Y--------- -YYYDWHHLL GYYLGGP--- EEG--EGPGG ILLLDDDNLL WEIIIDRGDQ Y--------- -YYYDWHHLL GYYLGGP--- EEG--DGPGG VMMMDDESLL WEVVVERGPQ Q--------- -YYYDWHHLL GVVTLLD--- LLQGGNGKGG LLLLDDETKK WEKKKPGGAS P--------- -YYYDYQQPP GVVSLLD--- PPQGGNGKGG LLLLDDETKK WEKKKPGGEA P--------- -YYYDYQQPP GVVTLLD--- SSKGGNGKGG LLLLDDETKK WEQQQPGGAA P--------- -YYYDYQQPP GVVTLLD--- PPEGGNGKGG LLLLDDKTKK WEQQQPGGAA P--------- -YYYDYQQPP GVVSLLD--- VVKGGNGKGG LLLLDDETKK WERRRPGGAA P--------- -YYYDYQQPP GVVSLLD--- VVKGGNGKGG LLLLDDETKK WERRRPGGAA P--------- -YYYDYQQPP GVVSLLD--- VVKGGNGKGG LLLLDDETKK WERRRPGGAA P--------- -YYYDYQQPP GVVSLLD--- VVKGGNGKGG LLLLDDETKK WERRRPGGAA P--------- -YYYDYQQPP GVVTLLD--- PPKGGNGKGG LLLLDDETKK WERRRPGGSA P--------- -YYYDYQQPP ---------- ---------- ---------- ---------- ---------- ---------- GVVSLLD--- VVKGGNGKDD VLLLLL-RSS ---------- ---------- ---------- GIICLLD--- KKEGGNAAGG LLLLLLSEKK GSNNNRLFPI S--------- -RRRTYEENN GIISIID--- PPYGGNGKGG LLLLDDETKK WEAAAEGEAA P--------- -YYYDYQQPP GIISLLD--- PPCGGNGKGG LLLLDDETKK WEVVVEGESA Q--------- -YYYDYQQPP GLLCLLD--- KKDGGNAEGG LLLLLLSDKK WEKKKPGHSP L--------- -YYYDYQQPP GIICIID--- KKDGGNAEGG LLLLLLSEKK WEKKKPGHSP L--------- -YYYDYQQPP GIICLLD--- EEEGGNAKGG LLLLLLSDKK WEKKKPGHSP L--------- -YYYDYQQPP GIICLLD--- EEEGGNAKGG LLLLLLSDKK WEKKKPDISP L--------- -YYYHYQQPP GIICLLD--- KKEGGNAAGG LLLLLLSEKK WEKKKPGHSP L--------- -YYYDYQQPP GIITLLE--- AANGGTPSGG LLLLDDKTKK WPAAADEKTV P--------- -YYYDYQQPP GIITLLE--- AADGGSPSGG LLLLDDKTKK WPAAADGKVV P--------- -YYYDYQQPP ---------- ---------- ---------- ---------- ---------- ---------- GIIIMMD--- AAEGGNAKGG VEEEFFKNVV WSRRRGDRKA L--------- -YYYDYQQPP GIIVMMD--- AAEGGYAKGG ILLLFFSDII WTKKKGDKKA L--------- -YYYDYQQPP TLLGVVE--- SSLSSVPVLL QTTTSSHESS GEAAASQFEE I--------- -LLLSNNNGG SMMLSSD--- DDDHHGGRTT EYYYNNDGAA WMPPPTADDM QAADDAAADD GYYYDALLII RLLLSSN--- KKDHHGGRTT EYYYTTAGAA WIPPPTDGDL RAK--KKADD GYYYDALLPP L--NNEVLSS EAVN-TIED- KLKKDDRYYG GNNFWWDDDR RKKKKRRIHH HSLLTTTGGE L--SSGVMTT ETVR-CFEE- SLKKEEAYYG GNNVWWDDDA AKKKKHHLYY YAIIDDDGGQ L--RRDYMSS EALP-QFEN- VPLLAAKYYG GHHFWWDDDR RAAAANNVQQ QTIIDDDGGA L--RRDYMTT EALP-QFEN- VPLLSSKYYG GHHFWWDDDR RAAAANNVQQ QTIIDDDGGA L--RRDYMSS EGLP-QFEN- VPLLSSKYYG GHHFWWKKKR RDDDDNNVQQ QTIIDDDGGA L--YYDTLTT EGTD-MVED- VPLLGGRYYG GRRFWWDDDT TRRRRHHLQQ QEIIDDDGGD L--YYDTLTT EGTR-MVES- LGLLAAKYYG GHHVWWDDDY YRRRRHHLQQ QTLLDDDGGA L--YYDTMTT EGTN-MIEG- DPLLNNGYYG GRRIWWDDDR RRRRRHHLQQ QALLDDDGGE P--HHNVMSS EAAN-VFKDF PAAA--LYYG GSSVWWDDDQ QRRRRIIIQQ QTLLQQQTT- P--HHNIMSS EAAN-VFKDF PAAA--LYYG GSSVWWDDDQ QRRRRIIIQQ QTLLQQQKK- P--HHNVMSS EAAN-VFRDF PAAA--LYYG GSSVWWDDDQ QRRRRIIIQQ QTLLTTTQQ- P--HHNVMSS EAAN-VLRDF PAAA--LYYG GSSVWWDDDQ QRRRRIIVQQ QTLLPPPQQ- P--HHNVMSS EAAN-VLRDF PAAA--LYYG GSSVWWDDDQ QHHHHIIVQQ QTLLSSSKK- P--HHNVMSS EAAN-VLRDF PAAA--LYYG GSSVWWDDDQ QRRRRIIVQQ QTLLSSSKK- P--HHNVMSS EAAN-VLRDF PAAA--LYYG GSSVWWDDDQ QRRRRIIVQQ QTLLSSSKK- P--HHNVMSS EAAN-VLRDF PAAA--LYYG GSSVWWDDDQ QRRRRIIVQQ QTLLSSSKK- P--HHNVMSS EAAN-VVQNF PAAA--LYYG GKKVWWDDDQ QRRRRIIVQQ QTLLLLLPP- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IAHN-LRLTS DYAA--RVVA AGG------- ---------- ---------- NYYWWGLFSS ICCL-FYTTA LMAA--GVVH HVVLDDNNNI IMMMMIIDEE ESLLPPPQQ- P--HHNVMSS EGAK-AFALF MEAA--MYYG GHHVWWDDDT TEEEERRIQQ QTIIDDDGGE P--HHNVMSS EGAK-AFALF MEAA--HYYG GHHVWWDDDT TEEEELLVQQ QTIIDDDGGK P--HHNTMSS SGAT-AFTKF LQDD--LYYG GRRCIIQQQA ARRRRLLRQQ QTLLDDDGGN P--HHNTMSS SGAK-AFLQF LQDD--LYYG GRRVYYSSSP PGGGGIIKQQ QTLLDDDGGD P--HHKTMSS SGAK-AFSKF LQDD--LYYG GSSVYYSSSP PGGGGMMKQQ QLIIDDDGGE P--HHKTMSS SGAK-AFSKF LQDD--LYYG GSSVYYSSSP PGGGGIIKQQ QLIIDDDGGP P--HHKTMSS SGAA-AFRTF LQDD--LYYG GRRVYYDDDP PGGGGLLKQQ QTLLDDDGGS P--RRNVMSS EGSN-HIKKF PAEE--LYYG GNNIFFEEED DSSSSYYLQQ QTIIDDDPPQ P--RRNIMSS EGSN-HIKKF PAEE--LYYG GNNIFFEEED DTTTTHHLQQ QTIIDDDPPM --------SS LGGV-TVCRE LKEE--LVVI IKKVYY---- ---------- ---------- P--FFNVMAA EGAK-LFRRY PTDDRRQYYG GCCFYYRRRQ QEEEELLFQQ QTIIDDDGGD P--FFDVMSS EGAN-KWRRW NVDDMMQYYG GCCFYYKKKS STTTTLLYQQ QTIIDDDGGS G--RREKSSS RDEI-MAFES SFTTGGLKKP PQQEVVLLL- ---------- ---------- I--KKNVMTT STGSYMMDFQ LQAAMMRFFG GNNQWWDDDH HTTTTPPKKK KVFFNNNPPG P--KKNLLTT STGNYMMDFK LAAAMMHFFG GNNTWWDDDH HTTTTPPKKK KVFFDDDPPG MAAAAL---E ELPPPLHNNN MVVSKDDSSS SIFYEEEDDG KKWWNAAEEI IIIEIIAEPE MVVVVL---E EVPPPLHNNN VVVNKDDSSS SIFYEEEDDG KKWWQAAEEI IIIDIIAQPE MAAAAL---E EVPPPAHGGG VVVDTNNEEG SIWREEEGGG KKFFHVVKKA AAATIIAEPT MAAAAL---E EVPPPAHGGG VVVDTNNEEA SIWREEEGGG KKFFHAAEEA AAATIIPEPP MAAAAL---E EIPPPAHGGG VVVDTNNQQG AIWQDDDDDG TTFFEAAKKI IIITIIPVPD LVVVVF---E ELPPPAHNNN CVVSKDDSSS SIYRDDDKKD KKWWAVVRRI IIIEIIAEAD MAAAAL---E ELPPPAHNNN CVVSKDDSSA SIYRDDDNNG SSWWHLLKKI IIIDIIAEPS MVVVVL---E ELPPPAHGGG VVVSEDDSSA SVHRQQQNNG SSWWGIIRRI IIIEIIAEPE LIIIIP--LE EIFFFLHGGG CAASNIIRRF YKG------- ---------T TTTWSSEKVQ LIIIIP--LE EIFFFLHGGG CAASNIIRRF YKG------- ---------T TTTWSSEKVQ LIIIIP--LE EIFFFLHGGG CAASTIIRRF YKG------- ---------T TTTWSSEKVQ LIIIIP--LE EIFFFLHGGG CAASTIIRRF FKG------- ---------T TTTWSSQKVQ LIIIIP--LE EIFFFLHGGG CAASTIIRRF YKG------- ---------T TTTWSSEKVQ LIIIIP--LE EIFFFLHGGG CAASTIIRRF YKG------- ---------T TTTWSSEKVQ LIIIIP--LE EIFFFLHGGG CAASTIIRRF YKG------- ---------T TTTWSSEKVQ LIIIIP--LE EIFFFLHGGG CAASTIIRRF YKG------- ---------T TTTWSSEKVQ HIIIIP--LE EIFFFLHGGG CAASTIIRRF YKG------- ---------T TTTWSSEKVE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AGGGGAPILC CLSSSIHVVV VEESSGGGGG SDY------- ---------A AAAVVVKRKD LIIIIP--LE EIFFFLHGGG CAASTVVRRF YKG------- ---------K KKKWAAEKVK LIIIIP--LE EIFFFLHGGG CAASSIIRRF YKG------- ---------K KKKWAAEKVQ LLLLLP--LE EIFFFLHGGG SAASNMMRRF FKG------- ---------S SSSWSSELAP LLLLLP--LE EIFFFLHGGG SAATNMMRRF FKG------- ---------S SSSWNNEIVS LLLLLP--LE EIFFFLHGGG SAASNMMRRF FKD------- ---------T TTTWSSEIVS LLLLLP--LE EIFFFLHGGG SAASNMMRRF FKE------- ---------T TTTWSSEVVS LLLLLP--LE EVFFFLHGGG CAATNMMRRF FKG------- ---------S SSSWSSEVAS ALLLLP--LE EVFFFLHGGG CAAGGIIRRI HPNS------ ---------T TTTHAATLVF ALLLLP--LE EVFFFLHGGG CAAGAIIRRI HPNP------ ---------V VVVQTTSLVT ---------- ---------- ---------- ---------- ---------- ---------- LTTTTP--LE EIFFFLHGGG CAAXXXXXXX X--------- ---------- ---------- ITTTTP--LE EIFFFLHGGG CAANKVVHHF KKSD------ ---------E EEEAKKVIDP ---------- ---------- ---------- ---------- ---------- ---------- --------LE EIFFFPWTTT TAATQLLLLI YEG------- ---------- ---------E --------LE EICCCAWSSS TAATQLLLLI YEG------- ---------- ---------E NLIIIPPKKA PPLVDIISDK FLLGGIGEER QYSSNNFFVV TGGKKKGIIF FRRAD----- PLVVVDDKKM PPLVDIISDR FLVGGLGEER QYTTNNHHRR AGGRKKGLLY YRREP----- ELLLLGGGGA PPLVDILSDR FLVGGTGEER QYSSDDHHVV AGGSRRGIIA ARRAP----- KLLLLGGGGA PPLVDILSDR FLVGGTGEER QYSSDDRRKK AGGSHHGIIA ARRTP----- DLLLLGGGGA PPLVDILSDK YLVGGLGEEH QYSSDDMMVV TGGKEEGIIV VKKTP----- QLVVVGGKKA PPLVDILSDR FLVGGTGDDL QYSSDDFFKK TGGKRRGIIV VRRATGG--- QLIIIPPKKA PPLVDILSDR FLVGGTGEEH QYSSDDFFRR TGGKQQGIIV VRRAG----- QLLLLDDGGA PPLVDILSDR FLVGGTGEER QYSSDDFFRR TGGSRRGIIV VKKAA----- SKKKKMMPPE PGLIDILSDR FLFLLHGDDR QYSSNNQQRR TGGQFFGSSI IRRGGQQVDL SKKKKMMPPE PGLIDILSDR FLFLLHGDDR QYSSNNKKRR TGGQFFGSSI IKKGGQQVDL PKKKKMMPPE PGLIDILSDR FLFLLHGDDR QYSSDDQQRR TGGQFFGSSI IKKGGQQVDL PKKKKMMPPE PGLIDILSDH FLFLLHGDDR QYSSDDQQRR TGGQFFGSSI IKKDGQQVDL PKKKKLLPPE PGLIDILSDR FLFLLHGDDR QYSSDDQQRR TGGQFFGSSI IKKGGQQVDL PKKKKLLPPE PGLIDILSDR FLFLLHGDDR QYSSDDQQRR ---------- ---------- PKKKKLLPPE PGLI------ ---------- ---------- ---------- ---------- PKKKKLLPPE PGLIDILSDR FLFLLHGDDR QYSSDDQQRR TGGQFFGSSI IKKGGQQVDL PKKKKMMPPE PGLIDILSDR FLFLLHGDDR QYSSDDKKRR VGGQFFGSSI IKKGGQQVDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YAAAAGGVVS SNEFPAIFDL LIF------- ---------- ---------- ---------- SKEEEAAPPE PGLIDIISDR FLFLLHGDDR QYTTDDRRKK VGGQFFGSSI IRRGGTTVDL SKEEEPPPPE PGLIDIISDR FLFLLHGDDR QYTTDDRRKK VGGQFFGSSI IRRGGTTVDL PLQQQIIPPE PGLIDFISDR FLFLLHGDDR QYEEDDKKVV TGGQWWGLLI IKKGSAAAEK PLQQQFFPPE PGLIDFISDR FLFLLHGDDR QYEEDDKKKK TGGQWWGLLI IKKGSVVADE PLEEEIIPPE PGLIDFISDR FLFLLHGDDR QYEEDDKKVV TGGQWWGLLL LKKGSKKAEN PLEEEIIPPE PGLIDFISDR FIFLLHGDDR QYEEDDKKVV TGGQWWGLLL LKKGSKKAEN PLRRRIIPPE PGLIDFISDR YLLLLHGDDR QYEEDDAAVV AGGQWWGLLL LKKGSVVYEK SKSSSAAPPE PALIDIISDR FLVLLHGDDR QYSSDDLLKK NSSQYYGSSV VTTESKKVG- SKEEEAAPPD PALIDIISDR FLVLLHGDDR QYSSDDKKKK NSSQFFGSSI ISSETKKVED ---------- ---------- ---------- ---------- ---------- ---------- --EEEEEEEM GGMMDIISDR YLFRRHGDDR QYSSDDAARR TGGQFFGAAI IRRDARRVDL LVGGGVVEED GGMIDIISDR FLVRRHGDDR QYTTDDEEKK TGGQFFGAAI ISSDLVVIDL ---------- ---------- ---------- ---------- ---------- ---------- AKAAAGGPPA IPLPDIIADQ TLIMMDGKKR LFSSDDHHFF IYYEVVRQQV V--------- AKAAAGGPPA VPLPDIISDS RLVMMDGKKR LFSSDDHHRR VYYETTAQQV V--------- ---------- AGHLLTGGPM MESRDDGGGY VVVSLDDNNN QQQQFFFFYY PPEEGGGKGM ---------- SGAAATGGPM MSSRDDGGGY IIISLNNNNN QQQQFFFFYY PP--GGGRGM ---------- NGRFFAGGPM MESRDDGGGY WWWSLDDDDD QQQQFFFFYY PPDDGGGPAQ ---------- NGKFFAAAPM MESRDDGGGY WWWSLDDDDD QQQQFFFFYY PPDDGGGPGE ---------- NGKFFGYYPM MESRDDGGGY WWWSLDDEEE QQQQFFFFYY PPGGDDDGAM ---------- KNGLLNGGPM MESRDDGGGY FFFSLDDPPP QQQQFFFFYY PPEEGGGDGM ---------- TSALLNGGPM MESRDDGGGY FFFSLDDEEE QQQQFFFFYY PPDDGGGKGM ---------- ASGLLNGGPM MESRDDGGGY FFFSLDDEEE QQQQFFFFYY PPVVGGGRGI TTCCQQPEVV KGKIIPGGPM MQSLDDGGGY AAASLDDKKK QQQQFFFFYY --PPDDDIRG TTCCQQPEVV KGKVVPGGPM MQSLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPNNNIRG KKSSQQPEVV KGKVVPGGPM MQSLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPDDDIRG DDSSQQPEVV KGKVVAGGPM MQSLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPDDDIRG KKSSQQPEVV KGKVVAGGPM MQSLDDGGGY IIISLDDKKK QQQQFFFFYY --PPDDDIRG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKSSQQPEVV KGKVVAGGPM MQSLDDGGGY IIISLDDKKK QQQQFFFFYY --PPDDDIRG KKSSQQPEVV KGKVVPGGPM MQSLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPDDDIRG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EECCQQPDII KGKVVPGGPM MQSLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPDDDIKG EECCQQPDTT KGKIIPGGPM MQSLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPDDDLKG TTWWQQSDEE QGQLLRGGPM MQTLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPGGGVEG TTWWQQSDEE QGKLLRGGPM MQSLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPKKKVEG SSFFQQFDQQ KGKLLRGGPM MQSLDDGGGY AAASLDDRRR QQQQFFFFYY --PPEEEMDG TTFFQQFEQQ KGKLLRGGPM MQSLDDGGGY AAASLVVVVV SSSSFFFFYY --PPEEEMEG EEEEQQYSQQ KGHLLRGGPM MQSLDDGGGY VVVSLDDEEE QQQQFFFFYY GGQQDDDVKG ----PPIEYY KGRIIEGGPM MQSLDDGGGY VVVSLDDDDD QQQQFFFFYY --PPEEEVKG ----EEIPYY KGRIIEGGPM MQSLDDGGGY VVVSLDDDDD QQQQFFFFYY --PPEEEVRG ---------- ------GGPK KQSVDDGGGY VVVSFDDKKK QQQQFFFFYY --PPNNNVKG KKEEAAPEFF KGRLLLGGPM MQSLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPEEEVAG KKEERRPPYY KGRLLEGGPM MQSLDDGGGY VVVSLDDKKK QQQQFFFFYY --PPKKKVSG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M MSSWDDGGGY FFFSLDD--- ---------- --------KG ---------- ---------M MSSWDDGGGY YYYSLDD--- ---------- --------KG KKNNNN---- -SSGGGGEEI DFVVGEE--- ------RSSH QQQRRRSGGG DASSDYPPP- KKNNNN---- -EEGGGGEEL EFVVGRR--- ------RAAH QQQRRRWGGG DASSDYPPP- LLHGGG---- -DDGGGGTTL AYVVPDDGG- ------RAAH QQQRRREGGG DCSSDYPPPS MMNGGG---- -NNGGGGEEL DYVVPDDGG- ------RAAH QQQRRREGGG DCSSDYPPPS MMNGGG---- -NNGGGGTTL DFVVPAAGG- ------RSSH QQQRRREGGG DCSSDYPPPS KKDGGG---- -NNGGGGEEF DFLLPKKGG- ------RPPH QQQRRRQGGG DCSSDYPPP- KKDNNN---- -DDGGGGQQF DFVVGEE--- ------RVVH QQQRRRQGGG DASSDFPPP- KKEDDD---- -GGGGGGSSL DFTTGDDGG- ------RPPH QQQRRREGGG DSSSDYPPPS VVLVVVDDVT TNNGGGGKKL NFVVGKKEEP PPGGGPLAAH EEERRRPGGG DCSSD----- VVLIIIDDVT TNNGGGGKKL NFVVGKKEEP PPGGGPLAAH EEERRRPGGG DCSSD----- VVLIIIDDVT TKKGGGGKKL NFVVGKKEEP PPGGGPLAAH EEERRRPGGG DCSSD----- VVLIIIDDVT TKKGGGGTTL NFVVGKKEEP PPGGGPLAAH EEERRRPGGG DCSSD----- VVLVVVDDVT TKKGGGGKKL NFVVGKKEEP PPGGGPLAAH EEERRRPGGG DCSSD----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVLVVVDDVT TKKGGGGKKL NFVVGKKEEP PPGGGPLAAH EEERRRPGGG DCSSD----- VVLIIIDDVT TKKGGGGKKL NFVVGKKEEP PPGGGPLAAH EEERRRPGGG DCTTD----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVLIIIDDVT TKKGGGGKKL NFVVGKKEEP PPGGGPLAAH EEERRRPGGG DCSSD----- VVLIIIDDVT TKKGGGGKKL NFVVGKKEEP PPGGGPLAAH EEERRRPGGG DCTTD----- HHLIIIDDVT TKKGGGGKKI NFVVGAAEEP PPGGGPLAAH EEERRRPGGG DCTTD----- HHLIIIDDVT TNNGGGGKKI NFVVGAAEEP PPGGGPLAAH EEERRRPGGG DCTTD----- HHIIIIDDVT TKKGGGGSSI NFVVGDDEEP PPGGGPLAAH EEERRRPGGG DCTTD----- HHIIIIDDGT TKKGGGGTTI NFVVGDDEEP PPGGGPLAAH EEERRRPGGG DCTTD----- HHLIIIDDVT TKKGGGGSSI NFVVGAAEEP PPGGGPLAAH EEERRRPGGG DCTTD----- TTVVVVNNIP PSSGGKKEEI NFIIGKKIIE EEGGGPLAAH EEERRRPGGG DCTTD----- TTLIIIDDVP PTTGGHHVVI NFIIGKKVVP PPGGGPLAAH EEERRRPGGG DCTTD----- VVLIIIDDVT TKKGGGGTTV NFVVGKKEEP PPGGGPLAAH DDDRRRPCCG DSTTD----- TTVLLLDDIV VNNGGGGKKL NFVVGGGEEP PPGGGPLPPH EEERRR---- ---------- HHVIIIDDVT TNNGGGGSSL NFVVANNEEP PPGGGPLPPH EEERRRPGGG DCTTDANNND ---------- ---------- ---------- ---------- ---------- ---------- DDAYYYLLKY YWWDDGGEEL VFVVYEELLG GGGGG-RAAH IIIRRRGSSS ALYYS----- DDEFFFLLKY YWWDDGGEEL KFIIYAAEEK KKGGG-RPPH QQQRRRGAAR ALYYGDGGGN ------- ------- SSVKR-- SSV---- SSV---- ------- ------- SS----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- DDA---- ------- ------- NNRLVAE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSSSKAAKKP SAATTTPRRR AVPTGAARLA AAQQQLRRAL LLLLLLPGPR IKKKAAYQAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ------MARR gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AWWTTTFFFS IIVLLAASSE GGGKTVGVVI ISSSAAAKQV PQAAAWHWWL PPGKKHHAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AERAAEEAFF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MGGL GKEEEPPHTT ---------- ---------- ---------- ---------- -----LKNNS QGCLLGGDQQ ---------- ---------- ---------- ---------- ---------- ---------- SAAPPPTTTL LLNRRTTPPN AAAASHRPPT TRRRVVPYRT NPPPRCPHHA RHSLLVVQHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M KRREEFF--- ---------- ---------- ---------- ---------- ---------M KRFIIVVGPP ---------- ---------- -AIFKRRDDP TFPSPKMAMK KAAEDDDDLA AYVCYTTINR ---------- ---------- --MLKPPDDP TFPTPRDAMR RAAEDDDDIA AYVAYVTVNA ---------- ---------- ---MRPPDDP TFASPELAMQ QAAEEEEEFA AYTLSPF--R ---------- ---------- ---MRPPDDP TFASPKLAME EAAENNNNFA AYTLSPF--K ---------- ---------- ---LRPPDDP TFPSAKLAME EGGEKKKKLA AFTMSPA--K ---------- ---------- --MWKPPDDP SFPSPRLAAK KAAETTTTIA AYVMDPR--Q ---------- ---------- --MWRPPDDP TFPSPRMAVK KAAEKKKKLA AYVRNPAG-K ---------- ---------- --MWRPPDDP TFPSPKMAMQ QAAERRRRLG GYVLDPR--R ---------- -------MAA AKC--CCGGP GYTPLEAMK- -GGEEEEEIV VYLCYRTTEA ---------- ---------- ---------- --------M- -GGEEEEEIV VYLCYRTIEA VLIAAAARGG LLPG-AAHSS SQC--CCGGP GYSPLEAMK- -GGEEEEEIV VYLCYGTIEA ---------- ---------- ---------- -------MK- -GGEEEEEII IYLCYRTIEA ---------- -------MAA AKC--CCGGP GYTPLEAMK- -GGEEEEEIV VYLCYRTTEA TLQAAAAQPP MRPIASSTAA AKC--CCGGP GYTPLEAMK- -GGEEEEEIV VYLCYRTTEA ---------- -------MAA AKC--CCGGP GYTPLEAMK- -GG------- -------TEA ---------- -------MAA AKC--CCGGP GYTPLEAMK- -GGEEEEEIV VYLCYRTTEA AQPLLLLSGG QLWQEDDTAA AKC--CCGGP GYTPQEAMK- -GGEEEEEIV VYLCYRTTEA TNTHHHHTYY CTLVFTTSPP PKC--CCGGP GYTPLEAMK- -GGEEEEEIV VYLCYRTTEA ---------- -------MAA AKC--CCGGP GYTPLEAMK- -GGEEEEEIV VYLCYRTTEA IMEAAAAAVV ETAAAAANGG GTCTAKKGGP GYTPLEAMEK KGGEKKKKLV VYVCYNTINK ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM MKC--CCGGP GYSPLDAMK- -GGEEEEEIV VYLCYRTINK -MALLLLDHH GVVNEKKKSS SVNCKSSGGP GYSPIESMS- -GGESSSSLI IYVAYATIEK -MGLLLLQHH AVVSEKKVNN NQQCKSSGGP GYSPLEAMS- -GGETTTTLI IYVAYATIEK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --RQVGGGGP GYTPLAAMS- -GGEKKKKLI IYVAYTTIDK ---------- -MAAAAANGG GACGATTGGP GYTPLEAMEK KGGEKKKKLL LYVCYNTINK ---------- --MSPNNCGG GKC----GGP GYSPADAIK- -GGEEEEEVL LFVA--NADG ---------- --MP---CPP PKC----GGP GYSPADAIK- -GGEEEEEVL LFVA--HRDG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -SECKCCGGP GYTPLDAVRN NGGEKKKKLL LYVCQPLEEH ---------- ---------- ---------- -------MRS SGGEKKKKLL LYTTQPLEPH ---------- ---------- -------MMP GLT--DILIS SLLRFFFFLY YFSWHGIQYD --------AA LAAG-AALAA AGLRAFFAAD ETQSPYMPKI ITTEEEEEFV VYVTGVGGDE SMHLLLLRAA LVSGLAALAA AAAGVRRAAD ETASPYMKKI ITTEDDDDYV VYVTGAGGDE RADFFFFAAV VVNKKVHHKV VELLLPPNLH HHFWWNAASS -NNIERLIVV GRRRRRIIII APDFFFFAAV VVDKKIYYKL LDLLLPPGLH HHFWWNAASS -NFLERLIVV ARRRRRIIIV RPDAAAAAAV IVKKKVHHTV VTMMMPPGFH HHFWWNAASS -LFLERLIII GRRRRRIVVI KPDAAAAAAV IVKQQVHHTV VTMMMPPGFH HHFWWNAASS -LFIERLIII GRRRRRIIII KPDGGGGAAV VVDQQVHHQL LIMMMPPGFH HHFWWNAASS -LFLERLIII GRRRRRIIIV QPDAAAAAAV VVDSSVGGQV VAMMMPPGLH HHFWWNAASS -NHMERLVVV GRRRRRIIIL KPDAAAACCV VVDQQVGGVT TDMMMPPGLH HHFWWNAASS -NHVERLVVV DRRRHHIIIL RPDAAAAGGV LLDQQVGGRV VEMMMPPALH HHFWWNAASS -YHVERLIVV GRRRRRIIIV APDYYYYAAT VVDQQIHHRL LPMMMPPKLH HHSWWNTTSS --TKSRLILL GMMMRRIVVV APDYYYYAAT VVDQQIHHRL LPMMMPPKLH HHSWWNTTSS --TKSRLILL SIIIRRIVVV APDYYYYAAT VIDQQIHHRL LPMMMPPRLH HHSWWNAASS --TKSRLMLL CMMMRRIVVV APDYYYYAAT VVDQQIHHRL LPMMMPPKLH HHSWWNTTSS --TKARLVLL AIIIRRIVVV APDYYYYAAT VVDQQIHHRL LPMMMPPKLH HHSWWNTTSS --TKSRLVLL SIIIRRIVVV APDYYYYAAT VVDQQIEE-- ---------- ---------- ---------- ---------- APDYYYYAAT VVDQQIHHRL LPMMMPPKLH HHSWWNTTSS --TKSRLVLL SIIIRRIVVV APDYYYYAAT VVDQQIHHRL LPMMMPPKLH HHSWWNTTSS --TKSRLVLL SIIIRRIVVV APDYYYYAAT VVDQQIHHRL LPMMMPPKLH HHSWWNTTSS --TKSRLVLL SIIIRRIVVV APDYYYYAAT VVDQQIHHRL LPMMMPPKLH HHSWWNTTSS --TKSRLVLL S--------- APDYYYYAAT VVDQQIHHRL LPMMMPPKLH HHSWWNTTSS --TKSRLVLL SIIIRRIVVV KLDYYYYAAT VLDQQIHHRL LPVVVIIGLH HHSWWNSSSS --SAKRLILL SLLLRRVVVV ---------- ---------- --MMMPPNLH HHSWWNTTSS --SKVRLILL CIIIRRIVVV KPDYYYYAAT VVDQQIHHRL LPMMMPPNLH HHSWWNTTSS --SKVRLILL CIIIRRIVVV KPDYYYYAAT VVDKKIHHRL LPVVVPPGLH HHTWWNSSSS --SAERLIAA SVVVRRIVVI KPDYYYYAAT VLDKKIHHRL LPVVVPPGLH HHTWWNSSSS --SAQRLIVV GVVVRRVVVI ---------- ---------- --MMMPPGLH HHSWWNSSSS --SADRLVLL SIIIRRIAAI KPDYYYYAAT VVDSSIHHRL LPMMMPPGLH HHSWWNSSSS --SVDRLVLL SIIIRRIAAI KPDYYYYGGT VVDQQIHHRL LPVVVTTGLH HHSWWNAASS --SASRLILL SLLLRRVVVV GPDAAAAFFT VVNQQISSRV VDVVVPPGVH HHTWWNAASS --TEKRLIVV CNNNRRIIII GPDAAAAFFT VVNQQISSRV VDVVVPPGVH HHTWWNAASS --TEKRLIVV CNNNRRIVVI ---------- ---------- ---------- ---------- ------MVPP KSSSVVEKKV HGDYYYYAAT VVDQQIHHRT TYTTTNNHLH HHSWWNTTSS V-VPTRLVLL CNNNRRIVVI HGDYYYYSST VVDQQVHHRT TFTTTNNGLH HHSWWNAASS VEVPKRLVLL SNNNFFIIIL DITDDDDKKN PMVSSLKKDG GPVVVKKEEL DDSPPTPPII --VQGGMLQQ SDDDRRLVVT EQDKKKKVVT ILRQQINNSV VSVVVGGRAH HHGFFSAA-- ----DRFWTT GDDDRRIIIF EQDKKKKVVT VANKKVNNTL LSVVVGGRAH HHSFFTDD-- ----DRLWAA GDDDKKIVVF TTKNPRRRRR EEEKKIKKKI PVVVVVSGGY SRRRRVHHPP DDIIISSSAG E------EEE TTKDKRRRRR RRRAAAKKKV PAAARRTGGY TKKKKVHHPP DDIIISSSAG P------DDD TTKHPTTTTT QQQRRHKKKI PIIIKKTGGY SRRRRVHHPP EEIIISSSTG AGGKKKKDDD TTKDPTTTTT KKKKKHKKKI PVVVKKTGGY SRRRRIHHPP DDIIISSSTG GGGKKKKDDD VVKEPLLLLL KKKKKHKKKI PVVVKKTGGY SRRRRIHHPP EEIIISSSTG GGGEEEEDDD TTKDPLLLLL KKKFFAKKKI PLLLRRTGGY SRRRRVHHPP GGIIITTTAG A------EEE TTKDPTTTTT QQQKKVKKKI PLLLRRTGGY ARRRRVHHPP DDIIISSSAG P------EEE TTKDPRRRRR EEERRVKKKI PLLLRRTGGY SRRRRIHHPP DDVVVSSSAG P------EEE VVGEPRRRRR AAAKKHKKKI AIIIKKCNNV SNNNNSHHAA SSEEEVVVNL D------LLL VVGEPRRRRR AAAKKHKKKI PIIIKKCNNL GNNNNSHHAA SSEEEIIISL D------PPP VVGDPRRRRR AAAKKHKKKI AIIIKKCGGL GYYYYSHHAA SSEEEIIISL D------SSS VVGEPRRRRR AAAKKHKKKI PIIIKKCNNL GFFFFSHHPP SSEEEVVVSL D------PPP VVGEPRRRRR AAAKKHKKKI PIIIKKCEEL AFFFFSHHAA SSEEEIIISL D------VVV ---------- ---------- PIIIKKCEEL AFFFFSHHAA SSEEEIIISL D------VVV VVGEPRRRRR AAAKKHKKKI PIIIKKCEEL AFFFFSHHAA SSEEEIIISL D------VVV VVGEPRRRRR AAAKKHKKKI PIIIKKCEEL AFFFFSHHAA SSEEEIIISL D------VVV VVGEPRRRRR AAAKKHKKKI AIIIKKCGGL GTTTTSHHPP TTEEEIIISL D------PPP ---------- ---------- ---------- ---------- ---------- ---------- VVGEPRRRRR AAAKKHKKKI PIIIKKCEEL AFFFFSHHAA SSEEEIIISL D------VVV TTADPRRRRR TTTSSHKKKV SIIINNIGGL GFFFFSHHAA SSDDDIIISL D------KKK VVGDPRRRRR AAARRHKKKV PVVVKKCGGL ANNNNSHHGG CCEEEIIISI D------PPP VVGDPRRRRR AAARRHKKKV PVVVKKCGGL ANNNNSHHGG CCEEEIIISL D------PPP TTKNPRRRRR SSSSSHKKKV PIIIKKTGGL AYYYYSHHAA SSEEEIIISL D------KKK TTKNPRRRRR AAASSHKKKV PIIIKKTGGL AYYYYSHHAA SSEEEIIISI D------KKK TTKNPRRRRR AAASSYKKKV PIIIKKTGGL AYYYYAHHAA SSEEEVVVSL D------EEE TTKNPRRRRR AAASSYKKKV PIIIKKTGGL AFFFFAHHTT --EEEVVVSL D------EEE TTLDPRRRRR AAAAAHKKKV AIIIKKTGGL GFFFFSHHAA SSEEEIIISL D------KKK VVEE-RRRRR KKKYYEHHHI PLLLLLN--L SFFFFSHHAA DDNNNIIISL E------AAA VVEE-RRRRR EEEYYQHHHI PLLLLLN--L SFFFFSHHAA DDNNNIIISL E------AAA VVG------- ---------- ---------- ---------- ---------- ---------- TTGDPRRRRR AAAKKAKKKI GVVVGGADDC TAAAATHHPP NNNNNIIISM D------AAA VVVDPRRRRR KKKEEVKKKI GVVVSSHNNV TAAAATHHAA NNNNNIIISM D------AAA SSLSAWWWWW DDDQQYPPP- -LLLFFLVVL AIIIIADDPP NNAAAQQQDV E------SSS VVHDPSSSSS NNNKKHKKKI TVVVSSGGGV VGGGGFFFPP GGMMMTTTGS D------DDD VVHDPAAAAA RRRVVSKKKI DVVVSSGGGV VGGGGLYYPP GGMMMTTTGS N------KKK GG-EEGGMDH YSFEPLGGGK KKIDRGDY-- ---------- DFWWNL---P EEEELSSEWW GGREEGGLDH DTFEPIGGGR RRVYRGPY-- ---------- DFWWNL---P GGGGMTTEWW GGTDDGPIDC ETFDVLGGGR RRIDRGPD-- ---------- DFWWNL---P DDDDMSSEWW GGTNNGPIDC ETFEVLGGGR RRIDRGPT-- ---------- DFWWNL---P DDDDMTTEWW GGTDDGPIDC ETFEILGGGR RRMDRGET-- ---------- DFWWNL---P DDDDMSSEWW GG-KKGGMDA QSFEPLGGGR RRVERGPY-- ---------- DGWWHL---G DDDDLTTEWW GG-EEGGIDH DNLEVLGGGR RRIDRGDY-- ---------- DFWWHL---G DDDDLTTEWW GG-DDGGVDH ESFDPLGGGR RRVERGPQ-- ---------- DFWWHL---G DDDDMTTEWW QQGNNGGLDG ETFEVKGGGT TTKPGGAP-- ---------- DFWWQP---R NNNNMSSEWW QQGNNGGLDG ETFEVKGGGT TTKPGGEP-- ---------- DFWWQP---R NNNNMSSEWW KKGNNGGLDG ETFEVKGGGT TTQPGGAP-- ---------- DFWWQP---R NNNNMSSEWW EEGNNGGLDG KTFEVKGGGT TTQPGGAP-- ---------- DFWWQP---R NNNNMSSEWW KKGNNGGLDG ETFEVKGGGT TTRPGGAP-- ---------- DFWWQP---R NNNNMSSEWW KKGNNGGLDG ETFEVKGGGT TTRPGGAP-- ---------- DFWWQP---R NNNNMSSEWW KKGNNGGLDG ETFEVKGGGT TTRPGGAP-- ---------- DFWWQP---R NNNNMSSEWW KKGNNGGLDG ETFEVKGGGT TTRPGGAP-- ---------- DFWWQP---R NNNNMSSEWW KKGNNGGLDG ETFEVKGGGT TTRPGGSP-- ---------- DFWWQP---R NNNNMSSEWW ---------- ---------- ---------- ---------- ---------- ---------- KKGNNGDVLP -RLECSGGG- ---------- ---------- ---------- -------ISS EEGNNAGLLD SEFNVKGGGR RRNRLFPS-- ---------- THLLENYYYA GGGGFSSIQQ YYGNNGGLDG ETFEVKGGGN NNAEGEAP-- ---------- DFWWQP---R NNNNMSSEWW CCGNNGGLDG ETFEVKGGGN NNVEGESQ-- ---------- DFWWQP---R NNNNMSSEWW DDGNNAGLLD SDFNVKGGGR RRKPGHSL-- ---------- DFWWQP---R NNNNMSSSWW DDGNNAGLLD SEFNVKGGGR RRKPGHSL-- ---------- DFWWQP---R NNNNMSSSWW EEGNNAGLLD SDFNIKNNNR RRKPGHSL-- ---------- DFWWQP---R KKKKMSSSWW EEGNNAGLLD SDFNIKNNNR RRKPDISL-- ---------- HFWWQP---R KKKKMSSSWW EEGNNAGLLD SEFNVKGGGR RRKPGHSL-- ---------- DYWWQP---R KKKKMSSSWW NNGTTPGLDG KTFEPKGGGT TTADEKTP-- ---------- DFWWQP---R NNNNMSSEWW DDGSSPGLDG KTFEPKGGGT TTADGKVP-- ---------- DFWWQP---R NNNNMSSEWW ---------- ---------- ---------- ---------- ---------- -----SSLRR EEGNNAGVFD KNFELVGGGT TTRGDRKL-- ---------- DYWWQP---H NNNNMAAEWW EEGYYAGIFD SDFNCIGGGT TTKGDKKL-- ---------- DFWWQP---Y DDDDMSSEWW LLSVVPLQSK HENGLSAAAK KKASQFEI-- ---------- SNHHNG---- EEEESSSRPP DDHGGGTEND DGEYVATTTY YYPTADDQGA AVVDAAAVAG DIRRLI---R NNNNMTTSFF DDHGGGTETN AGEYVATTTH HHPTDGDRGA KTT-KKKYAG DVRRLP---R NNNNLTTSFF AVPN------ TTEDKKKLEH KRRRGGRIIF WWWDRKRKHS LLLERM---E LPPHTTKLLM TVPR------ CCEESSSLEC KAAAGGKLLV WWWDAKRRYA IILERM---E VPPHTTKLLM ALPP------ QQENVVVPED LKKKGGRLLF WWWDRARRQT IILQQM---E VPPHVVREEY ALPP------ QQENVVVPED LKKKGGRLLF WWWDRARRQT IILNQM---E VPPHVVREEY GLPP------ QQENVVVPED LKKKGGKIIF WWWKRDRKQT IILNQM---E IPPHSSKDDY GTPD------ MMEDVVVPDI LRRRGGRLLF WWWDTRRRQE IIFEQL---E LPPHTTKAAY GTPR------ MMESLLLGDE LKKKGGRLLV WWWDYRRRQT LLLEQM---E LPPHTTKAAY GTPN------ MMEGDDDPQI LGGGGGRLLI WWWDRRRRQA LLVEQM---E LPPHAARTTY AAPN------ VVKDPPPAHV ALLLGGRIIV WWWDQRHEQT LLM-GL--LE IFFHSSATTQ AAPN------ VVKDPPPAHV ALLLGGHIIV WWWDQRHEQT LLM-GL--LE IFFHDDATTQ AAPN------ VVRDPPPADV ALLLGGHLLV WWWDQRHEQT LLL-GL--LE IFFHDDAAAQ AAPN------ VVRDPPPADV ALLLGGHLLV WWWDQRREQT LLL-GL--LE IFFHDDAAAQ AAPN------ VVRDPPPADV ALLLGGHLLV WWWDQHHEQT LLL-GL--LE IFFHDDAAAQ AAPN------ VVRDPPPADV ALLLGGHLLV WWWDQRHEQT LLL-GL--LE IFFHDDAAAQ AAPN------ VVRDPPPADV ALLLGGHLLV WWWDQRHEQT LLL-GL--LE IFFHDDAAAQ AAPN------ VVRDPPPADV ALLLGGHLLV WWWDQRHEQT LLL-GL--LE IFFHDDAAAQ AAPN------ VVQNPPPADV ALLLGGHLLV WWWDQRHEQT LLM-GH--LE IFFHAAASSQ ---------- ---------- ---------- ---------- ---------- ---------- AHSN------ LLLTDDDYPA ARRRAAITT- ---------- ---------- ---------- CCSL------ FFTTLLLMCL AGGGHHISSL DDDNIMRVES LLL-QANPLC LSSHNNINNQ GAPK------ AAALMMMEEV AMMMGGSLLV WWWDTEHRQT IIL-GL--LE IFFHDDAAAQ GAPK------ AAALMMMEDV AHHHGGSLLV WWWDTEHRQT IIL-GL--LE IFFHDDADDQ GAPT------ AATKLLLQHV DLLLGGHLLC IIIQARGEQT LLL-GL--LE IFFHAAKDDT GAPK------ AALQLLLQHV DLLLGGHLLV YYYSPGGEQT LLL-GL--LE IFFHAAKDDT GAPK------ AASKLLLQHV DLLLGGHLLV YYYSPGGEQL IIL-GL--LE IFFHSSKDDT GAPK------ AASKLLLQHV DLLLGGHLLV YYYSPGGEQL IIL-GL--LE IFFHSSKDDT GAPA------ AARTLLLQHV DLLLGGHLLV YYYDPGGEQT LLL-GL--LE VFFHSSKDDT GSPN------ HHKKPPPAHV ELLLGGSVVI FFFEDSKKQT IILPGA--LE VFFHTTSEEH GSPN------ HHKKPPPAHV ELLLGGSVVI FFFEDTKKQT IILPGA--LE VFFHTTSEEH GGPV------ TTCRLLLKCQ ELLLIICKKV YYY------- ---------- ---------- GAPK------ LLRRPPPTDC DQQQGGRLLF YYYRQEREQT IIL-GL--LE IFFHRRENNQ GAPN------ KKRRNNNVDL DQQQGGRLLF YYYKSTQTQT IIL-GI--LE IFFHKKKAAE DEPI------ MMFESSSFLK TLLLPPHVVE VVVL------ ---------- ---------- TGWSNNNYYY MMDFLLLQDA ARRRGGTIIQ WWWDHTRQKV FFVA----LE IFFWNNANNY TGWNNNNYYY MMDFLLLADP AHHHGGTVVT WWWDHTKQKV FFVA----LE ICCWAAHNNY GFNNNMMVVL LLKDLSWWWW WWFYEEEGKK NNEEPPPG-N PIPKKKAPPP PPPVTTDDLL GFNNNVVLLT TTKDLSWWWW WWFYEEEGKK QQEEEEPG-P PVDKKKMPPP PPPVTTDDLL GFGGGVVVVT TTTNLGWWWW WWWREEEGKK HHKKPPPADE PLGGGGAPPP PPPVTTDDLL GFGGGVVVVT TTTNLAWWWW WWWREEEGKK HHEEPPPKEK PLGGGGAPPP PPPVTTDDMM GFGGGVVVVT TTTNLGFFFF WWWQDDDGTT EEKKDDPADD PLGGGGAPPP PPPVTTDDLL GFNNNCCIIL LLKDLSWWWW WWYRDDDDKK AARRPPAPDQ PVGKKKAPPP PPPVTTDDMM GFNNNCCVVL LLKDLAWWWW WWYRDDDGSS HHKKPPPEDQ PIPKKKAPPP PPPVTTDNVV GFGGGVVVVL LLEDLAWWWW WWHRQQQGSS GGRRPPPPDQ PLDGGGAPPP PPPVTTDNLL GFGGGCCLLS SSNIQFNNNN EEG------- ----VVVVPS KKMPPPEPPP GGGITTDLLL GFGGGCCLLS SSNIQFNNNN GGG------- ----VVVVPS KKMPPPEPPP GGGITTDLLL GFGGGCCLLS SSTIQFNNNN GGG------- ----VVVVPP KKMPPPEPPP GGGITTDLLL GFGGGCCLLS SSTIQFNNNN DDG------- ----AAVVPP KKMPPPEPPP GGGITTDLLL GFGGGCCLLS SSTIQFNNNN GGG------- ----VVVVPP KKLPPPEPPP GGGITTDLLL GFGGGCCLLS SSTIQFNNNN GGG------- ----VVVVPP KKLPPPEPPP GGGITTDLLL GFGGGCCLLS SSTIQFNNNN GGG------- ----VVVVPP KKLPPPEPPP GGGITT---- GFGGGCCLLS SSTIQFNNNN GGG------- ----VVVVPP KKLPPPEPPP GGGITTDLLL GFGGGCCLLS SSTIQFNNNN GGG------- ----VVVVPP KKMPPPEPPP GGGITTDLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DYVVVVVVVF FFSGRGPPPP AAY------- ----LLKLYY VAGVVVSSSS NNNFPPPWFF GLGGGCCLLS SSTVFFEEEE DDG------- ----AAVVPS KEAPPPEPPP GGGITTDLLL GLGGGCCLLS SSSIFFEEEE DDG------- ----AAVVPS KEPPPPEPPP GGGITTDLLL GFGGGSSLLS SSNMIFTTTT DDG------- ----HHAVKP KQIPPPEPPP GGGITTDLLL GFGGGSSLLS SSNMIFTTTT DDG------- ----HHVVEP KQFPPPEPPP GGGITTDLLL GYGGGSSLLS SSNMIFNNNN DDD------- ----YYVVKP KEIPPPEPPP GGGITTDLLL GFGGGSSLLS SSNMIFNNNN DDE------- ----HHVVKP KEIPPPEPPP GGGITTDLLL GYGGGCCLLS SSNMVFTTTT DDG------- ----HHAIKP KRIPPPEPPP GGGITTDVLL AFGGGCCLLS SSGIFIVVVV EENS------ ----AAVIPS KSAPPPEPPP AAAITTDLMM AFGGGCCLLS SSAIFIDDDD KKNP------ ----AAVIPS KEAPPPDPPP AAAITTDLMM ---------- ---------- ---------- ---------- ---------- ---------- GYGGGCCFFX XXXXXX---- ---------- ---------- QEEEEEMGGG GGGMTTDLLL GFGGGCCLLA AAKVFFKKKK DDSD------ ----KKDGKL DGVEEEDGGG GGGISSDILL ---------- ---------- ---------- ---------- ---------- ---------- AFTTTTTLLS SSQLWIDDDD AAG------- -------WQA AAGPPPAIII PPPPVVDSAA CFSSSTTLLS SSQLWIDDDD EEG------- -------WQA AAGPPPAVVV PPPPVVDSNN DDKFLYYSSS SSGIRQDIII SNPKKKKPVG GGGKKVKKKG IIIFFHR--- ---------- DDRFLYYSSS SSGLRQDIII TNPQQQQPRG GGGRRVKKKG LLLYYHR--- ---------- DDRFLYYSSS SSGTRQDVVV SDPNNNNPVG GGGSSVRRRG IIIAARR--- ---------- DDRFLYYSSS SSGTRQDVVV SDPKKKKPKG GGGSSVHHHG IIIAARR--- ---------- DDKYLYYAAA AAGLHQDVVV SDPNNNNPVG GGGKKVEEEG IIIVVKK--- ---------- DDRFLYYSSS SSGTLQDVVV SDPEEEEPKG GGGKKVRRRG IIIVVSRGG- ---------- DDRFLYYSSS SSGTHQDVVV SDPNNNNPRG GGGKKVQQQG IIIVVRR--- ---------- DDRFLYYSSS SSGTRQDVVV SDPNNNNPRG GGGSSVRRRG IIIVVRK--- ---------- DDRFLYYSSS SSLHRQDIII SNPKKKKPRG GGGQQIFFFG SSSIIVRQQE EEELTTCQPL DDRFLYYSSS SSLHRQDIII SNPKKKKPRG GGGQQIFFFG SSSIIVKQQE EEELTTCQPL DDRFLYYSSS SSLHRQDIII SDPRRRRPRG GGGQQLFFFG SSSIIVKQQE EEELKKSQPL DDHFLYYSSS SSLHRQDVVV SDPRRRRPRG GGGQQLFFFG SSSIIVKQQD DDDLDDSQPL DDRFLYYSSS SSLHRQDIII SDPRRRRPRG GGGQQLFFFG SSSIIVKQQE EEELKKSQPL DDRFLYYSSS SSLHRQDIII SDPRRRRPR- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDRFLYYSSS SSLHRQDIII SDPRRRRPRG GGGQQLFFFG SSSIIVKQQE EEELKKSQPL DDRFLYYNNN NNLHRQDIII SDPRRRRPRG GGGQQIFFFG SSSIIVKQQE EEELKKSQPL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDLLIIILLL LL-------- ---------- ---------- ---------- ---------- DDRFLYYSSS SSLHRQDIII TDPNNNNPKG GGGQQIFFFG SSSIILRTTE EEELEECQPV DDRFLYYSSS SSLHRQDIII TDTNNNNPKG GGGQQIFFFG SSSIIQRTTE EEELEECQPV DDRFLYYVVV VVLHRQNIII EDLNNNNPVG GGGQQLWWWG LLLIIQKAAG GGGKTTWQSP DDRFLYYVVV VVLHRQNIII EDVNNNNPKG GGGQQVWWWG LLLIIQKVVK KKKETTWQSP DDRFLYYVVV VVLHRQNIII EDPNNNNPVG GGGQQIWWWG LLLLLQKKKG GGGNSSFQFP DDRFIYYVVV VVLHRQNIII EDPNNNNPVG GGGQQIWWWG LLLLLQKKKG GGGNTTFQFP DDRYLYYVVV VVLHRQNIII EDPKKKKPVG GGGQQVWWWG LLLLLQKVVT TTTKEEEQYP DDRFLYYSSS SSLHRQDIII SDPKKKKVKS SSSQQVYYYG SSSVVHTKKE EEE----PIL DDRFLYYSSS SSLHRQDIII SDPNNNNPKS SSSQQVFFFG SSSIIHSKKE EEED---EIL ---------- ---------- ---------- ---------- ---------- ---------- DDRYLYYSSS SSRHRQDIII SDRNNNNPRG GGGQQVFFFG AAAIIQRRRN NNNLKKEAPV DDRFLYYNNN NNRHRQDIII TDPNNNNPKG GGGQQLFFFG AAAIICSVVK KKKLKKERPR ---------- ---------- ---------- ---------- ---------- ---------- DDQTLWWNNN NNMDRLDIII SDPKKKKPFY YYYEEKVVVR QQQVVN---- ---------- DDSRLWWNNN NNMDRLDIII SDPHHHHPRY YYYEEKTTTA QQQVVN---- ---------- ---AHKKLLT TAMMMLLESR RGGRRRYVTS SLYYSSSTWW DNNYPGLLKW WMMKLLNN-- ---SAEEAAT TAMMMIISSR RGGRRRYITS SLYYSSSSWW NNNYPGLLRW WMMKVVNN-- ---NRTTFFA AGMMMVVESR RGGRRRYWTS SLYYSSSTWW DDDYPGVVPA AQQLAAHH-- ---NKAAFFA AGMMMVVESR RGGRRRYWTS SLYYSSSTWW DDDYPGVVPV VEEMAANN-- ---NKTTFFG GGMMMVVESR RGGKRRYWTS SLYYSSSTWW DEEYPDRRGA AMMMAANN-- --AKGAALLN NGMMMVVESR RGGRRRYFTS SLYYGGGAVV DPPYPGIIDW WMMKLLDD-- --ATAEELLN NGMMMVVESR RGGRRRYFTS SLYYRRRAWW DEEYPGIIKW WMMKVVDD-- ---AGPPLLN NGMMMVVESR RGGRRRYFSS SLYYAAASWW DEEYPGIIRW WIIKAAEE-- LLVKKRRIIP PGMMMIIQSL LGGKRRYATS SLYYSSSDWW DKKY-DLLIE EGGVMMLLDD LLVKKRRVVP PGMMMIIQSL LGGKRRYVTS SLYYSSSAWW DKKY-NLLIE EGGVMMLLDD LLVKKKKVVP PGMMMIIQSL LGGKRRYVTS SLYYSSSAWW DKKY-DLLIE EGGVMMLLDD LLVKKQQVVA AGMMMIIQSL LGGKRRYVTS SLYYSSSAWW DKKY-DLLIE EGGVMMLLDD LLVKKRRVVA AGMMMIIQSL LGGKRRYITS SLYYSSSAWW DKKY-DLLIE EGGVMMLLDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLVKKRRVVA AGMMMIIQSL LGGKRRYITS SLYYSSSAWW DKKY-DLLIE EGGVMMLLDD LLVKKRRVVP PGMMMIIQSL LGGKRRYVTS SLYYSSSDWW DKKY-DLLIE EGGVMMLLDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVKKKKVVP PGMMMIIQSL LGGKRRYVTS SLYYSSSKWW DKKY-DMMIE EGGVMMLLDD VVVKKIIIIP PGMMMIIQSL LGGKRRYVTS SLYYSSSIWW DKKY-DLLLE EGGVMMLLDD PPIQQKKLLR RGMMMIIQTL LGGKRRYVTS SLFFSSSAWW DKKY-GLLVK KGGHIILLDD PPIQKKKLLR RGMMMIIQSL LGGKRRYVTS SLFFSSSAWW DKKY-KLLVQ QGGHIILLDD PPIKKSSLLR RGMMMIIQSL LGGKRRYATS SLFFSSSAWW DRRY-ELLMK KGGHIIIIDD PPIKKSSLLR RGMMMIIQSL LGGKRRYATS SLFFSSSAWW VVVY-EIIMK KGGHIIIIDD PPVKHRRLLR RGMMMIIQSL LGGKRRYVTS SLFFSSSRWW DEEYGDLLVK KGGHMMLLDD LLVKRKKIIE EGMMMLLQSL LGGKRRYVTS SLYYKKKKWW DDDY-EHHVS SGGTMMVVNN LLVKRQQIIE EGMMMLLQSL LGGKRRYVSS SLYYKKKKWW DDDY-ENNVS SGGTMMLLDD ---------- -GKKKIIQSV VGGKRRYVTS SFYYSSSTWW DKKY-NVVVE EGGVMMLLDD VVLKRRRLLL LGMMMLLQSL LGGRRRYVSS SLFFSSSPWW DKKY-EMMVA AGGTIIVVDD RRVKRRRLLE EGMMMLLQSL LGGKRRYVSS SLYYSSSPWW DKKY-KMMVQ QGGHIIVVDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMMVVSSW WGGKRRYFSS SLLLAAANWW D--------K KGGDDDAALL ---------- --MMMVVSSW WGGQRRYYTS SLLLAAANWW D--------K KGGDDDEELL -----SGGGL LLLIIKEFFV DF---AARSS SSQQVVVRLL SGGDDDDDSY YYYY------ -----EGGGL LLLLLKEFFV DF---AARAA AAQQVVVRLL WGGDDDDDSF FFFY------ -----DGGGL LLLLLDDYWV EF---YYRAA AAQQIIIRLL EGGDDDDDSF FFFYSSVKK- -----NGGGL LLLLLKDYFV SF---YYRAA AAQQIIIRLL EGGDDDDDSF FFFYSSV--- -----NGGGL LLLLLKDFWV DF---YYRSS SSQQIIIRLL EGGDDDDDSF FFFYSSV--- -----NGGGI IIIFFPKFFL EW---HHRPP PPQQVVVRLL QGGDDDDDSY YYYY------ -----DGGGM MMMFFPNFFV DF---QQRVV VVQQIIIRLL QGGDDDDDSY YYYF------ -----GGGGL LLLLLPGFFT EV---LLRPP PPQQIIIRLL EGGDDDDDSY YYYYSS---- DTTTTNGGGL LLLLLPNFLV DFPPPAALAA AAEELLLRYY PGGDDDDDIW WWW------- DTTTTNGGGL LLLLLPNFLV DFPPPAALAA AAEELLLRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLLLPNFLV DFPPPAALAA AAEELLLRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLLLPNFLV DFPPPAALAA AAEELLLRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLLLPNFLV DFPPPAALAA AAEELLLRYY PGGDDDDDIW WWW------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DTTTTKGGGL LLLLLPNFLV DFPPPAALAA AAEELLLRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLLLPNFLV DFPPPAALAA AAEEIIIRYY PGGDDDDDIW WWW------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DTTTTKGGGL LLLLLPNFLV DFPPPVVLAA AAEELLLRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLLLPNFLV DFPPPVVLAA AAEEIIIRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLIIPNFFV DFPPPAALAA AAEEMMMRYY PGGDDDDDIW WWW------- DTTTTNGGGL LLLIIPNFFV DFPPPSSLAA AAEEMMMRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLIIPNFFV DFPPPAALAA AAEEMMMRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLIIPDFFV DFPPPSSLAA AAEEMMMRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLIIPNFFV DFPPPSSLAA AAEEMMMRYY PGGDDDDDIW WWW------- DPPPPSGGKM MMMIIRDFLI DFEPPYYLAA AAEEMMMRYY PGGDDDDDIW WWW------- DPPPPTGGHM MMMIIKNFLI DFPPPYYLAA AAEEMMMRYY PGGDDDDDIW WWW------- DTTTTKGGGL LLLVVKNFLV DFPPPCCLAA AADDIIIRFF PGGDDDDDIL LLL------- DVVVVNGGGM MMMLLENFLV DFPPPGGLPP PPEEMMMR-- ---------- ---------- DTTTTNGGGI IIILLEDFLV DFPPPSSLPP PPEEMMMRYY PGGDDDDDIW WWWADDA--- ---------- ---------- ---------- ---------- ---------- ---------- AYYYYWDDGK KKKLLEDFAV DFG----RAA AAIIMMMRFF GSSAASSS-- ---------- LYYYYWDDGK KKKLLEQFAI DFK----RPP PPQQMMMRFF GRRAAGGGPA AAADNNRLLQ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ARRREEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMMNNAAAKQ SSEATPRRVP GGGGLLLTAA LDDASSLLPR TAQQLLLLTT TTPGSPVVVI gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKAAYQQEAA AAAFIIIQLL SRRRSSESKK GGRRKKKTRS SPPGLVESSA VVAAAVVVVS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MAAGRR RSSTLLLNRR THHHPPNPLL AAPPAAASPP PPPRVPLRLV RRPPPTTIIV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AIIPPPRDD PPFPSSKKKM MAKAPPPPED ---------- ---------- ---------- --MMKKKPDD PPFPTTRRRD DARAPPPPED ---------- ---------- ---------- ----SSSPDD PPFASSEEEL LAQAPPPAEE ---------- ---------- ---------- ----TTTPDD PPFASSKKKL LAEAPPPAEN ---------- ---------- ---------- ----TTTPDD PPFPSSKKKL LAEGPPPVEK ---------- ---------- ---------- --MMTTTPDD PPFPSSRRRL LAKAPPPPET ---------- ---------- ---------- --MMTTTPDD PPFPSSRRRM MAKAPPPAEK ---------- ---------- ---------- --MMSSSPDD PPFPSSKKKM MAQAPPPRER ---------- ---------- ---------- -KCCKKKCGG PPYTPPEEEA AM-GPPPREE ---------- ---------- ---------- ---------- ---------- ---GPPPREE AAAQWAAAPP PGKKHGLLLI AAPARLLLLA AQCCKKKCGG PPYSPPEEEA AM-GPPPREE ---------- ---------- ---------- ---------- ---------- -M-GPPPREE ---------- ---------- ---------- -KCCNNNCGG PPYTPPEEEA AM-GPPPREE --------AA ARAAEGLLLQ SSVAQMRRRS SKCCNNNCGG PPYTPPEEEA AM-GPPPREE ---------- ---------- ---------- -KCCNNNCGG PPYTPPEEEA AM-G------ ---------- ---------- ---------- -KCCNNNCGG PPYTPPEEEA AM-GPPPREE --------GG GEEEPGQQQP WWFLSQLLLD DKCCDDDCGG PPYTPPEEEA AM-GPPPREE ----LLLLQQ QCLLGFNNNT EELHTCTTTT TKCCNNNCGG PPYTPPEEEA AM-GPPPREE ---------- ---------- ---------- -KCCNNNCGG PPYTPPEEEA AM-GPPPREE PRRPCPPPRR RSLLVLMMME GGAAAETTTA ATCCHHHKGG PPYTPPEEEA AMKGPPPREK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -KCCSSSCGG PPYSPPDDDA AM-GPPPREE ---------- ------MMMA TTVLDGVVVK KVNNCCCSGG PPYSPPEEES SM-GPPPRES ---------- ------MMMG TTVLQAVVVK KQQQCCCSGG PPYSPPEEEA AM-GPPPRET ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --RRLLLGGG PPYTPPAAAA AM-GPPPSEK ---------- ---------- ------MMMA AACCGGGTGG PPYTPPEEEA AMKGPPPREK ---------- ---------- ---------N NKCCGGG-GG PPYSPPDDDA AI-GPPPREE ---------- ---------- ---------- -KCCGGG-GG PPYSPPDDDA AI-GPPPREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -SEEKKKCGG PPYTPPDDDA AVNGPPPVEK ---------- ---------- ---------- ---------- ---------- -MSGPPPREK ---------- ---------- ---------- --------MM PPLT--DDDI ILSLDDDDRF --------KK KREEFG---- -----LAAAA AGLLFFFFAA DDTQSSYYYM MPITGGGQEE --------KK KFIIVSMMMH FFALRLVVVA AAAAAAARAA DDTASSYYYM MKITGGGQED LAAYYACCTT GGGGIIRRRR AAADFVVNKT TTSKIVVVKV LLPPNNEELH HHHFFGWAAS IAAYYAAAVV GGGGVVAAAA PPPDFVVDKT TTGKVIIIKL LLPPGGEELH HHHFFGWAAS FAAYYLLLPP DDDS--RRRR PPPDAVVKGT TTGKIVVVTV MMPPGGEEFH HHHFFGWAAS FAAYYLLLPP DDDS--KKKK PPPDAVVKGT TTGQIVVVTV MMPPGGEEFH HHHFFGWAAS LAAFFLMMPP DDDS--KKKK PPPDGVVDTK KKGQIVVVQL MMPPGGEEFH HHHFFGWAAS IAAYYAMMPP EEEK--QQQQ PPPDAVVDAR RRASIVVVQV MMPPGGEELH HHHFFGWAAS LAAYYVRRPP MMMNGGKKKK PPPDAVVDQT TTGQVVVVVT MMPPGGEELH HHHFFGWAAS LGGYYALLPP GGGE--RRRR PPPDAVLDDT TTAQIVVVRV MMPPAAEELH HHHFFGWAAS IVVYYPCCRR NNNGTTAAAA PPPDYTVDKQ QQSQVIIIRL MMPPKKEELH HHHSSGWTTS IVVYYPCCRR NNNGIIAAAA PPPDYTVDKH HHSQVIIIRL MMPPKKEELH HHHSSGWTTS IVVYYPCCGG NNNGIIAAAA PPPDYTIDKQ QQCQVIIIRL MMPPRREELH HHHSSGWAAS IIIYYPCCRR NNNGIIAAAA PPPDYTVDKQ QQCQVIIIRL MMPPKKEELH HHHSSGWTTS IVVYYPCCRR NNNGTTAAAA PPPDYTVDKQ QQCQVIIIRL MMPPKKEELH HHHSSGWTTS IVVYYPCCRR NNNGTTAAAA PPPDYTVDKQ QQCQVIII-- ---------- ---------- ---------- ----TTAAAA PPPDYTVDKQ QQCQVIIIRL MMPPKKEELH HHHSSGWTTS IVVYYPCCRR NNNGTTAAAA PPPDYTVDKQ QQCQVIIIRL MMPPKKEELH HHHSSGWTTS IVVYYPCCRR NNNGTTAAAA PPPDYTVDKQ QQSQVIIIRL MMPPKKEELH HHHSSGWTTS IVVYYPCCRR NNNGTTAAAA PPPDYTVDKQ QQCQVIIIRL MMPPKKEELH HHHSSGWTTS IVVYYPCCRR NNNGTTAAAA PPPDYTVDKQ QQCQVIIIRL MMPPKKEELH HHHSSGWTTS LVVYYTCCNN GGGGIIKKKK LLLDYTLDST TTSQVIIIRL VVIIGGKKLH HHHSSGWSSS ---------- ---------- ---------- ---------- MMPPNNEELH HHHSSGWTTS IVVYYPCCRR SSSGIIKKKK PPPDYTVDKS SSSQVIIIRL MMPPNNEELH HHHSSGWTTS LIIYYTAAAA GGGGIIKKKK PPPDYTVDST TTSKVIIIRL VVPPGGEELH HHHTTGWSSS LIIYYTAAAA GGGGIIKKKK PPPDYTLDNT TTSKVIIIRL VVPPGGEELH HHHTTGWSSS ---------- ---------- ---------- ---------- MMPPGGEELH HHHSSGWSSS LIIYYTAATT GGGGIIKKKK PPPDYTVDSS SSSSVIIIRL MMPPGGEELH HHHSSGWSSS LLLYYTCCNN GGGGIIKKKK PPPDYTVDNT TTSQVIIIRL VVTTGGEELH HHHSSGWAAS VLLFFTAA-- ---AAAGGGG PPPDATVNET TTCQVIIIRV VVPPGGEEVH HHHTTGWAAS VLLFFTAA-- ---ARRGGGG PPPDATVNET TTCQIIIIRV VVPPGGEEVH HHHTTGWAAS ---------- ---------- ---------- ---------- ---------- ---------- LLLYYVCCPP NNNDEEHHHH GGGDYTVDAT TTCQVIIIRT TTNNHHEELH HHHSSGWTTS LLLYYVTTPP NNNDEEHHHH GGGDYTVDET TTCQIVVVRT TTNNGGEELH HHHSSGWAAS LYYFFNWWGG DDDRQQDDDD IIITDNMVQL LLGSVLLLDG VVKKEEKKEL DDDSSQPPPI FVVYYWTTVV EEEMGGEEEE QQQDKTLRGT TTGQVIIISV VVGGRREEAH HHHGGGFAA- YVVYYWTTAA EEEVGGEEEE QQQDKTANKQ QQGKVVVVTL VVGGRREEAH HHHSSDFDD- SAALCPPG-K PERRRFLIGL LLLSSIIDDD DTTKPNNNNP PEEEEEPIII IIIEEVVVVK SAAYCPPA-K PERRRYLIAL LLLSSIVDDD DTTKPDDDDK KRRRRRPVVA AVVEVAAAAG SSSLSPPTGH AERRRFLIGL LLLSSVIDDD DTTKPHHHHP PQQQQQAIIH HIIDEIIIIA SAALSPPAGH AERRRYLIGL LLLSSIIDDD DTTKPDDDDP PKKKKKAIIH HIIEEVVVVK SAALSPPTGH AERRRYLIGI IIISSIVDDD DVVK-EEEEP PKKKKKAIIH HIIEEVVVVA SCCLCPPAPH PERRRYLVGL LLLSSILDDD DTTKPDDDDP PKKKKKPLLA AIIETLLLLE SMMLCPPAPH PERRRYLVDI IIISSILDDD DTTKPDDDDP PQQQQQPVVV VIINELLLLE AAALCPPAPH PERRRYLIGI IIISSIVDDD DTTKPDDDDP PEEEEEPIIV VIIEELLLLR SCC----FGD SSRRNKLIGL LLLSSVVDDD DVVGSEEEEP PAAAAAPLLH HIISEIIIIA SCC----FGD SSRRDKLISI IIISSVVDDD DVVGSEEEEP PAAAAAPLLH HIINEIIIIA SCC----FGD SSRRTKLMCL LLLSSVVDDD DVVGSDDDDP PAAAAAPLLH HIIEDIIIIA SCC----YGD IARRTKLVAL LLLSSVVDDD DVVGTEEEEP PAAAAAPLLH HIIKDIIIIT SCC----FGD SSRRTKLVSL LLLSSVVDDD DVVGSEEEEP PAAAAAPLLH HIIEDIIIIA ---------- ---------- ---------- ---------- ---------- ---KDIIIIA SCC----FGD SSRRTKLVSL LLLSSVVDDD DVVGSEEEEP PAAAAAPLLH HIIKDIIIIA SCC----FGD SSRRTKLVSL LLLSSVVDDD DVVGSEEEEP PAAAAAPLLH HIIKDIIIIA SCC----FGD SSRRNKLVSF FFFSSVVDDD DVVGTEEEEP PAAAAAPLLH HIIKDIIIIE SCC----FGD SSRRTKLVSL LLL------- ---------- ---------- ---------- SCC----FGD SSRRTKLVSL LLLSSVVDDD DVVGSEEEEP PAAAAAPLLH HIIKDIIIIA SCC----HGD PKRRRFLISL LLLSSVVDDD DTTATDDDDP PTTTTTPLLH HVVEDIIIIE SCC----YGD AVRRNKLICL LLLSSVVDDD DVVGTDDDDP PAAAAAPIIH HVVYEVVVVW SCC----YGD SVRRNKLICL LLLSSVVDDD DVVGSDDDDP PAAAAAPIIH HVVYEVVVVW SCC----HGD PERRRFLISL LLLSSVIDDD DTTKTNNNNP PSSSSSPLLH HVVADIIIIQ SCC----HGD PQRRRFLIGI IIISSVIDDD DTTKTNNNNP PAAAAAPLLH HVVEDIIIIT SCC----HGD ADRRRYLVSL LLLSSAIDDD DTTKENNNNP PAAAAAPLLY YVVKEIIIIE SCC----HGD ADRRRYLVSL LLLSSAIDDD DTTKENNNNP PAAAAAPLLY YVVKEIIIID SCC----HGD PSRRRFLISL LLLSSVVDDD DTTLKDDDDP PAAAAAPLLH HVVEDIIIIE SCC----HDK PKRRSHLICL LLLSSIINNN NVVENEEEE- -KKKKKILLE EIISKLLLLS SCC----HDK PKRRSHLICL LLLSSVINNN NVVENEEEE- -EEEEEILLQ QIISKLLLLA ---------- ------MVKL LLLSSKVFFF FVVGG----- ---------- ---------- SCCHFPPGGK ETRRDRLVCL LLLSSVIDDD DTTGTDDDDP PAAAAAPLLA AII-DVVVVK SCCYYDDSSK TKRRDRLVSL LLLSSILDDD DVVVTDDDDP PKKKKKPIIV VII-DVVVVK LKK-----GK RGGGPQMLSL LLLGGVTTTT TSSLYSSSSA ADDDDDKFFY Y---DLLLLK ---------- -DRRRFFWGL LLLTTIFDDD DVVHSDDDDP PNNNNNPLLH HII-FVVVVD ---------- -DRRRYLWGL LLLTTVFDDD DVVHSDDDDP PRRRRRPLLS SII-FVVVVK KSSSRLVGDI SSSALLGNNE EEE--GGPGG GLMLLSSSSF FEEPPKEDDR GGGY------ GTTTKYVGDI SSSALLGGGP PPP--GGPGG GFLLLTTTTF FEEPPREYYR GGGY------ ATSSRPVGEV SSSTLLGGGA AAAGKGGAPP GFIMMTTTTF FDDVVREDDR GGGD------ KTSSRPIGDV SSSTLLGGGG GGGGKGGPPP GFIMMTTTTF FEEVVREDDR GGGT------ ATSSRPIGEV SSSTLLGGGG GGGGEGGPPP GFILLTTTTF FEEIIREDDR GGGT------ ETSSRPVGGV TTTALLGNNA AAA--GGPGG GAMLLSSSSF FEEPPREEER GGGY------ ETAARPVGDI SSSALLGSSP PPP--GGPGG GFILLNNNNL LEEVVREDDR GGGY------ RTSSRPIGDV SSSALLGSSP PPP--GGPGG GFVMMSSSSF FDDPPREEER GGGQ------ ACSSNTSLSM VVVNTTLGGD DDD--QGKGG SVLLLTTTTF FEEVVTEPPG GGGP------ ACGGNLSLSM IIISSSLGGD DDD--QGKGG GVLLLTTTTF FEEVVTEPPG GGGP------ ACGGYVSLSM IIISTTLGGD DDD--KGKGG GVLLLTTTTF FEEVVTEPPG GGGP------ TCGGFFSLSM VVVSTTLGGD DDD--EGKGG GVLLLTTTTF FEEVVTEPPG GGGP------ ACAAFLSLSM IIISSSLGGD DDD--KGKGG GVLLLTTTTF FEEVVTEPPG GGGP------ ACAAFLSLSM IIISSSLGGD DDD--KGKGG GVLLLTTTTF FEEVVTEPPG GGGP------ ACAAFLSLSM IIISSSLGGD DDD--KGKGG GVLLLTTTTF FEEVVTEPPG GGGP------ ACAAFLSLSM IIISSSLGGD DDD--KGKGG GVLLLTTTTF FEEVVTEPPG GGGP------ ECGGTPSLTM IIISTTLGGD DDD--KGKGG GVLLLTTTTF FEEVVTEPPG GGGP------ ---------- ---------- ---------- ---------- ---------- ---------- ACAAFLSLSM IIISSSLGGD DDD--KGKDD GLVLLRRRRL LEECC----- ---------- EIGGFPSLSM IIISCCLGGD DDD--EAAGG NFLLLEEEEF FNNVVRSRRL FFFS------ WCAANLSLCM IIISSSIGGD DDD--YGKGG GVLLLTTTTF FEEVVNEEEG EEEP------ WCAANPSLCM IIISSSLGGD DDD--CGKGG GVLLLTTTTF FEEVVNEEEG EEEQ------ QTAAYPSLSM IIISCCLGGD DDD--DAEGG NFLLLDDDDF FNNVVREPPG HHHL------ TTAAYPSLSM IIISCCIGGD DDD--DAEGG NFLLLEEEEF FNNVVREPPG HHHL------ ETAAYPALSL VVVSCCLGGD DDD--EAKGG NFLLLDDDDF FNNIIREPPG HHHL------ DTAAFPAR-L VVVSCCLGGD DDD--EAKGG NLLLLDDDDF FNNIIREPPD IIIL------ ETGGFPSLSM IIISCCLGGD DDD--EAAGG NFLLLEEEEF FNNVVREPPG HHHL------ SNSSFPSLDM IIISTTLGGE EEE--NPSGG NLLLLTTTTF FEEPPTPDDE KKKP------ ANSSFPSLDM IIISTTLGGE EEE--DPSGG NLLLLTTTTF FEEPPTPDDG KKKP------ ---------- ---------- ---------- ---------- ---------- ---------- KATTAPTLNM IIISIIMGGD DDD--EAKGG -FVEENNNNF FEELLTSGGD RRRL------ KHTTAPTLNM IIISVVMGGD DDD--EAKGG -FILLDDDDF FNNCCTTGGD KKKL------ KLAAISAQNK QQQDGGVNNE EEE--LPVLL NIQTTEEEEN NGGLLKESSQ FFFI------ DGVVGPFLGI TTTGLLSNND DDD--DGRTT AVEYYGGGGE EYYVVYMTTA DDDQVAAGAA KGVVGPLLGI TTTGLLSNNN NNN--DGRTT AVEYYGGGGE EYYVVHITTD GGGRIKKGKA ----LAADDW WNNNNLLNNE VVVVVPPPN- -TDDDG-EEK KD-YYNRRIH FWWLLLRRII ----FAADDW WNNNNLLSSG VIIVVPPPR- -CEEEG-EEK KEGYYNKKLH VWWLLLARLL ----KHHDDW WNNNNLLRRD YVVLLPPPP- -QNNNG-EEL LANYYHRRLH FWWLLLRRVV ----LHHDDW WNNNNLLRRD YVVLLPPPP- -QNNNG-EEL LSNYYHRRLH FWWLLLRRVV ----KHHDDW WNNNNLLRRD YVVLLPPPP- -QNNNG-EEL LSNYYHKKIH FWWLLLRRVV ----FAADDW WHHHHLLYYD TVVTTPPPD- -MDDDG-DDL LGAYYRRRLH FWWLLLTRLL ----LHHDDW WHHHHLLYYD TLLTTPPPR- -MSSSG-DDL LAGYYHRRLH VWWLLLYRLL ----LAADDW WHHHHLLYYD TVVTTPPPN- -MGGGG-QQL LNKYYRRRLH IWWLLLRRLL ----MGGDDY YQQQQPPHHN VVVAAPPPN- -VDDDGFHHA A-GYYSRRIF VWWWWWQHII ----MGGDDY YQQQQPPHHN IVVAAPPPN- -VDDDGFHHA A-GYYSHHIH VWWWWWQHII ----MGGDDY YQQQQPPHHN VIIAAPPPN- -VDDDGFDDA A-GYYSHHLH VWWWWWQHII ----LGGDDY YQQQQPPHHN VIIAAPPPN- -VDDDGFDDA A-GYYSHHLY VWWWWWQRVV ----SGGDDY YQQQQPPHHN VIIAAPPPN- -VDDDGFDDA A-GYYSHHLY VWWWWWQHVV ----LGGDDY YQQQQPPHHN VIIAAPPPN- -VDDDGFDDA A-GYYSHHLY VWWWWWQHVV ----LGGDDY YQQQQPPHHN VIIAAPPPN- -VDDDGFDDA A-GYYSHHLY VWWWWWQHVV ----LGGDDY YQQQQPPHHN VIIAAPPPN- -VDDDGFDDA A-GYYSHHLY VWWWWWQHVV ----MGGDDY YQQQQPPHHN VIIAAPPPN- -VNNNGFDDA A-GYYKHHLH VWWWWWQHVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---HHSSSN- -LTTTGSPPA A-SVVGIIT- ---------- ----KEETTY YEEEENNWWG LWWCCSSSL- -FTTTGACCA A-SVVVIISC LDDYYYIRDD ----FGGDDY YQQQQPPHHN VIIAAPPPK- -ALLLGFEEA A-GYYHSSLN VWWWWWTHII ----FGGDDY YQQQQPPHHN VIIAAPPPK- -ALLLGFDDA A-GYYHSSLN VWWWWWTHVV ----FGGDDY YQQQQPPHHN TIIAAPPPT- -AKKKGFHHD D-GYYRHHLT CIILLLAGRR ----FGGDDY YQQQQPPHHN TIIAAPPPK- -AQQQGFHHD D-GYYRHHLH VYYWWWPGKK ----FGGDDY YQQQQPPHHK TIIAAPPPK- -AKKKGFHHD D-GYYSHHLH VYYWWWPGKK ----YGGHHY YQQQQPPHHK TIIAAPPPK- -AKKKGFHHD D-GYYSHHLH VYYWWWPGKK ----FGGDDY YQQQQPPHHK TIIAAPPPA- -ATTTGFHHD D-GYYRHHLH VYYWWWPGKK ----FNNDDY YQQQQPPRRN VIISSPPPN- -HKKKGFHHE E-GYYNSSVH IFFWWWDKLL ----FNNDDY YQQQQPPRRN IIISSPPPN- -HKKKGFHHE E-GYYNSSVH IFFWWWDKLL ---------- ---------- ---GGPPPV- -TRRRDECCE E-PVVKCCKR VYY------- ----CGGDDY YQQQQPPFFN VVVAAPPPK- -LRRRGYDDD DRTYYCRRLN FYYWWWQRFF ----CGGDDY YQQQQPPFFD VVVAAPPPN- -KRRRGWDDD DMSYYCRRLN FYYWWWSQYY ----LQQSSN NNNNNGGRRE KEEEEPPPI- -MEEESSLLT TGPKKQHHVA EVV------- AADDYGGDDA ALLLLIIKKN VLLGGWWWSN YMFFFGQDDA AMKFFNTTIV QWWLLLHRKK AADDYDDDDA ALLLLPPKKN LVVGGWWWNN YMFFFGKDDA AMKFFNTTVV TWWLLLHKKK IIHSTGEERR MA-----LLP DDPLLLFIII NNMVSSSKKL LSSSSLWFYY YY--DGGKKN LLYADGQERR MV-----VVP DDPLLLFVVV NNVVNNNKKL LSSSSLWFYY YY--DGGKKQ VVQTDGAQQQ MA-----VVP DDPEEEFVVV GGVVDDDTTL LGGSSTWWRR RR--GGGKKH VVQTDGANQQ MA-----VVP DDPEEEFVVV GGVVDDDTTL LAASSTWWRR RR--GGGKKH VVQTDGANQQ MA-----IIP DDPDDDFCCC GGVVDDDTTL LGGAATWWQQ QQKKDGGTTE LLQEDGDEQQ LV-----LLP DDPAAAFVVV NNCVSSSKKL LSSSSTWYRR RR--KDDKKA LLQTDGAEQQ MA-----LLP DDPAAAFMMM NNCVSSSKKL LAASSLWYRR RR--NGGSSH LLQADGEEQQ MV-----LLP DDPTTTFVVV GGVVSSSEEL LAASSLWHRR RR--NGGSSG IIQTQT--GG LI--LLLIIF DDPTTTFVVV GGCASSSNNQ QFFYYEEG-- ---------- IIQTQK--GG LI--LLLIIF DDPTTTFVVV GGCASSSNNQ QFFYYEGG-- ---------- IIQTTQ--GG LI--LLLIIF NNPAAAFVVV GGCASSSTTQ QFFYYQGG-- ---------- VVQTPQ--GG LI--LLLIIF NNPAAAFVVV GGCASSSTTQ QFFFFEDG-- ---------- VVQTSK--GG LI--LLLIIF NNPAAAFVVV GGCASSSTTQ QFFYYEGG-- ---------- VVQTSK--GG LI--LLLIIF NNPAAAFVVV GGCASSSTTQ QFFYYEGG-- ---------- VVQTSK--GG LI--LLLIIF NNPAAAFVVV GGCASSSTTQ QFFYYEGG-- ---------- VVQTSK--GG LI--LLLIIF NNPAAAFVVV GGCASSSTTQ QFFYYEGG-- ---------- VVQTLP--GG HI--LLLIIF DDPSSSFVVV GGCASSSTTQ QFFYYEGG-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDESPQ--QQ AGNNLLLLLS WWKNNNYDDD VVVESSSSSR RGGSSDAY-- ---------- IIQTDGE-GG LI--LLLIIF DDPAAALVVV GGCASSSTTF FFFYYKDG-- ---------- VVQTDGK-GG LI--LLLIIF NNPDDDLVVV GGCASSSSSF FFFYYKDG-- ---------- RRQTDGN-GG LL--LLLIIF DDPDDDFVVV GGSASSSNNI IFFFFQDG-- ---------- KKQTDGD-GG LL--LLLIIF DDPDDDFVVV GGSATTTNNI IFFFFQDG-- ---------- KKQLDGE-GG LL--LLLIIF DDPDDDYVVV GGSASSSNNI IFFFFSDD-- ---------- KKQLDGP-GG LL--LLLIIF DDPDDDFVVV GGSASSSNNI IFFFFSDE-- ---------- KKQTDGS-GG LL--LLLVVF DDPDDDYVVV GGCATTTNNV VFFFFADG-- ---------- LLQTDPQPGG AL--LLLVVF EEPEEEFVVV GGCAGGGGGF FIIHHEENSS SS-------- LLQTDPMPGG AL--LLLVVF EEPEEEFVVV GGCAGGGAAF FIIHHEKNPP PP-------- ---------- ---------- ---------- ---------- ---------- ---------- FFQTDGD-GG LT--LLLIIF NNPNNNYVVV GGCAXXXXXX XXXXX----- ---------- YYQTDGS-GG IT--LLLIIF NNPAAAFVVV GGCANNNKKF FFFKKSDSDD DD-------- ---------- ---------- ---------- ---------- ---------- ---------- KKKVNPGA-- ----LLLIIF GGSNNNFSSS TTTATTTQQW WIIYYDAG-- ---------- KKKVDPGA-- ----LLLIIC GGENNNFTTT SSTATTTQQW WIIYYGEG-- ---------- AEKEEIIIPE EPPLLLEEEG ---NNNEKKA AVVVVVLLVT IIDSLDDDKW WWGGGGQDII AERDDIIIEQ QPPFFFEEEG ---PPPPKKM MVVVVVLLVT IIDSLDDDRW WWGGGGQDII VKKTTIIIPE EPPAAATTTA DDDEEEPQGA AVVVVVLLVT IIDSLDDDRW WWGGGGQDVV AEKTTIIIPE EPPAAAPPPK EEEKKKPQGA AVVVVVLLVT IIDSMDDDRW WWGGGGQDVV AKKTTIIIDV VPPAAADDDA DDDDDDDKGA ACCCCCLLVT IIDSLDDDKW WWGGGGQDVV VRKEEIIIPE EAAAAADDDP DDDQQQPKKA AVVVVVLLVT IIDSMDDDRW WWGGGGQDVV LKKDDIIIPE EPPAAASSSE DDDQQQPKKA AVVVVVLLVT IINSVDDDRW WWGGGGQDVV IRKEEIIIPE EPPAAAEEEP DDDQQQPKGA AVVVVVLLVT IINSLDDDRW WWGGGGQDVV ---WWSSSVK KVVIIIQQQV PPPSSSVWPE EMMMMMLLIT IILSLDDDRW WWLGGGQDII ---WWSSSVK KVVIIIQQQV PPPSSSVWPE EMMMMMLLIT IILSLDDDRW WWLGGGQDII ---WWSSSVK KVVIIIQQQV PPPPPPVWPE EMMMMMLLIT IILSLDDDRW WWLGGGQDII ---WWSSSAK KVVIIIQQQV PPPPPPVWPE EMMMMMLLIT IILSLDDDHW WWLGGGQDVV ---WWSSSVK KVVIIIQQQV PPPPPPVWPE EMMMMMLLIT IILSLDDDRW WWLGGGQDII ---WWSSSVK KVVIIIQQQV PPPPPPVWPE EMMMMMLLIT IILSLDDDRW WWLGGGQDII ---WWSSSVK KVVIIIQQQV PPPPPPVWPE EMMMMMLLIT ---------- ---------- ---WWSSSVK KVVIIIQQQV PPPPPPVWPE EMMMMMLLIT IILSLDDDRW WWLGGGQDII ---WWSSSVK KVVIIIEEEV PPPPPPVWPE EMMMMMLLIT IILSLDDDRW WWLGGGQDII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---VVVVVLR RKKLLLDDDL YYYYYYVFVS SLLLLLEEFP AAWFFSDDL- ---------- ---WWAAAAK KVVIIIKKKV PPPSSSVWPE EMMMMMLLIT IILSLDDDRW WWLGGGQDII ---WWAAAAK KVVIIIQQQV PPPSSSVWPE EMMMMMLLIT IILSLDDDRW WWLGGGQDII ---WWSSSHL LAAIIIPPPV KKKPPPVWPE EMMMMMLLIT FFLSLDDDRW WWLGGGQNII ---WWNNNHI IVVIIISSSV EEEPPPVWPE EMMMMMLLIT FFLSLDDDRW WWLGGGQNII ---WWSSSYI IVVIIISSSV KKKPPPVWPE EMMMMMLLIT FFLSLDDDRW WWLGGGQNII ---WWSSSHV VVVIIISSSV KKKPPPVWPE EMMMMMLLIT FFLSLDDDRW WWLGGGQNII ---WWSSSHV VAAIIISSSI KKKPPPVWPE EMMMMMLLIT FFVSLDDDRW WWLGGGQNII --THHAAAAL LVVAAAFFFI PPPSSSVWPE EMMMMMLLIT IILSMDDDRW WWLGGGQDII --KQQTTTAL LVVAAATTTI PPPSSSVWPD DMMMMMLLIT IILSMDDDRW WWLGGGQDII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------GGEM MMMMMMMMMT IILSLDDDRW WWRGGGQDII --EAAKKKKI IDDIIIPPPG KKKLLLTGED DMMMMMMMIS IIISLDDDRW WWRGGGQDII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------EEEW QQQAAAVIPA ADDDDDLLPV IISAADDDQF FFMGGGLDII ---------- ------EEEW QQQAAAVIPA AKKKKKLLPV IISSNDDDSF FFMGGGLDII PPVLGKKVKL GGGGGIFFFH APPP------ ---------- -------GHK KLTGLESRYN PPRLGRRVKI GGGGGLYYYH EPPP------ ---------- -------GAE EATGISSRYN PPVLGSSVRI GGGGGIAAAR APPP------ ---------- -------GRT TFAGVESRYN PPKLGSSVHI GGGGGIAAAR TPPP------ ---------- -------GKA AFAAVESRYN PPVLGKKVEI GGGGGIVVVK TPPP------ ---------- -------GKT TFGYVESRYN PPKLGKKVRI GGGGGIVVVS APPP------ ---------- -------NGA ALNGVESRYN PPRLGKKVQI GGGGGIVVVR APPP------ ---------- -------SAE ELNGVESRYN PPRHGSSVRL GGGGGIVVVR APPP------ ---------- -------SGP PLNGVESRYN PPRLGQQIFL GGGGGSIIIV GVVVVE---D ELLLTCQQQP PEEPPLVGKR RIPGIQSLYT PPRLGQQIFL GGGGGSIIIV GVVVVE---D ELLLTCQQQP PEEPPLVGKR RVPGIQSLYT PPRLGQQLFL GGGGGSIIIV GVVVVE---D ELLLKSQQQP PEEPPLVGKK KVPGIQSLYT PPRLGQQLFL GGGGGSIIIV DVVVVD---D ELLLDSQQQP PEEPPLVGKQ QVAGIQSLYT PPRLGQQLFL GGGGGSIIIV GVVVVE---D ELLLKSQQQP PEEPPLVGKR RVAGIQSLYT PPRL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPRLGQQLFL GGGGGSIIIV GVVVVE---D ELLLKSQQQP PEEPPLVGKR RVAGIQSLYT PPRLGQQIFL GGGGGSIIIV GVVVVE---D ELLLKSQQQP PEEPPLVGKR RVPGIQSLYT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPKLGQQIFL GGGGGSIIIL GVVVVE---D DLLLECQQQP PDDPPVIGKK KVPGIQSLYN PPKLGQQIFL GGGGGSIIIQ GVVVVE---D ELLLECQQQP PDDPPVTGKI IIPGIQSLYS PPVLGQQLWV GGGGGLIIIQ GVVVAG---E GKKKTWQQQS SDDVVPEGQK KLRGIQTLYN PPKLGQQVWA GGGGGLIIIQ GVVVAK---D GEEETWQQQS SDDVVPEGKK KLRGIQSLYN PPVLGQQIWV GGGGGLLLLQ GVVVAG---E GNNNSFQQQF FDDVVPQGKS SLRGIQSLYN PPVLGQQIWV GGGGGLLLLQ GVVVAG---E GNNNTFQQQF FEEVVPQGKS SLRGIQSLYN PPVLGQQVWA GGGGGLLLLQ GVVVYT---E DKKKEEQQQY YSSVVPQGHR RLRGIQSLYN VVKLSQQVYI GGGGGSVVVH EVVVVE---G K-----PPPI IEEAALYGRK KIEGLQSLYT PPKLSQQVFI GGGGGSIIIH EVVVVE---E HDDD--EEEI IPPAALYGRQ QIEGLQSLYT ---------- ---------- ---------- ---------- ---------- ---GIQSVYN PPRLGQQVFL GGGGGAIIIQ DRRRVN---D ELLLKEAAAP PEEPPVFGRR RLLGLQSLYS PPKLGQQLFL GGGGGAIIIC DNNNIKEEED ELLLKERRRP PPPAARYGRR RLEGLQSLYS ---------- ---------- ---------- ---------- ---------- ---------- PPFQYEEKVI DDDRRQVVVN ---------- ---------- ---------- ----VSSWYS PPRQYEEKTI GGGAAQVVVN ---------- ---------- ---------- ----VSSWYS STDQFYYYPE GGGMVKL--- --PSGGGLEE FDE----ARS HQQRLSSSGG GDDDDSSDSY SSNQFYYYP- GGGMAKV--- --PEGGGLEE FDR----ARA HQQRLWWWGG GDDDDSTDSF STDQFYYYPD GGAQVLA--- --PDGGGLTD WED----YRA HQQRLEEEGG GDDDDSTDSF STDQFYYYPD GGGEVMA--- --GNGGGLED FSD----YRA HQQRLEEEGG GDDDDSTDSF STDQFYYYPG DDAMVMA--- --ENGGGLTD WDA----YRS HQQRLEEEGG GDDDDSTDSF SADQFYYYPE GGGMVKL--- --PNGGGIEK FEK----HRP HQQRLQQQGG GDDDDSSDSY SADQFYYYPD GGGMVKV--- --PDGGGMQN FDE----QRV HQQRLQQQGG GDDDDSSDSY SSDQFYYYPV GGGIAKA--- --PGGGGLSG FED----LRP HQQRLEEEGG GDDDDSSDSY SDDQFYYY-P DDRGSVMDDD TTVNGGGLKN LDKPLGPALA HEERYPPPGG GDDDDSSDIW SADQFYYY-P NNRGSVMDDD TTANGGGLKN LDKPLGPALA HEERYPPPGG GDDDDSSDIW SADQFYYY-P DDRGSVMDDD TTVKGGGLKN LDKPLGPALA HEERYPPPGG GDDDDSSDIW SADQFYYY-P DDRGSVMDDD TTVKGGGLTN LDKPLGPALA HEERYPPPGG GDDDDSSDIW SADQFYYY-P DDRGSVMDDD TTVKGGGLKN LDKPLGPALA HEERYPPPGG GDDDDSSDIW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SADQFYYY-P DDRGSVMDDD TTVKGGGLKN LDKPLGPALA HEERYPPPGG GDDDDSSDIW SDDQFYYY-P DDRGSVMDDD TTVKGGGLKN LDKPLGPALA HEERYPPPGG GDDDDTSDIW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SKDQFYYY-P DDKGSVMDDD TTEKGGGLKN LDKPGGPVLA HEERYPPPGG GDDDDSSDIW SIDQFYYY-P DDKGAVMDDD TTKKGGGLKN LDKPDGPVLA HEERYPPPGG GDDDDTSDIW SADQFYYY-P GGEGSHIDDD TTEKGGGLKN FDAPDGPALA HEERYPPPGG GDDDDTSDIW SADQFYYY-P KKEGSHIDDD TTENGGGLKN FDAPDGPSLA HEERYPPPGG GDDDDTSDIW SADQFYYY-P EEDGSHIDDD TTEKGGGLSN FDDPEGPALA HEERYPPPGG GDDDDTSDIW SAVSFYYY-P EEEGSHIDDD TTEKGGGLTD FDDPDGPSLA HEERYPPPGG GDDDDTSDIW SRDQFYYYGQ DDKGSHMDDD TTEKGGGLSN FDAPEGPSLA HEERYPPPGG GDDDDTSDIW SKDQFYYY-P EEKGATMNND PPESGKKMED LDKEGGPYLA HEERYPPPGG GDDDDTSDIW SKDQFYYY-P EERGATMDDD PPITGHHMVN LDKPGGPYLA HEERYPPPGG GDDDDTSDIW STDQFYYY-P NNKGSVMDDD TTEKGGGLTN LDKPNGPCLA HDDRFPPPCG GDDDDTSDIL SPDQFYYY-P EEAGGTIDDD VVENGGGMKN LDGPYGPGLP HEER------ ---------- SPDQFYYY-P KKSGGHIDDD TTVNGGGISD LDNPYGPSLP HEERYPPPGG GDDDDTSDIW ---------- ---------- ---------- ---------- ---------- ---------- SND------- --KGKDDLLA YYNWDGGKED ADEGLG--RA HIIRFGGGSS SAAAAYSS-- SND------- --KGKDDLLL YYYWDGGKEQ ADAKLG--RP HQQRFGGGAR RAAAAYAGPA ------- ------- VVVKRR- VVV---- VVV---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AAA---- ------- ------- RRRLVVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158AQPSEAATTP CRRTAGTRLL AQLPPPAAAQ LLLLLTPPPG GGPRYQAATT FFIQLLASSS gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ----MASSPP TTLNRRTPPP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RSEEKKKKRK RRRSSSVVEI IIISVVAAKK KVVVSSSQQA VVQWAAHWPP PKKKAAVVII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AA EAAAAATTQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MGGG KEEEHHAAPP ---------- ---------- ---------- ---------- ---LLLKNQQ GLLLDDTTTT ---------- ---------- ---------- ---------- ---------- ---------- HPNNLLLLPA PPPPPPHPLT TTTRRRPPYY YTTIVVVPPR LLPCPPPHRR HLLLQQIIEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AA ---------- ---------- ---------- ---------- ---------- --------GG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------KK REEE------ ---------- ---------- ---------- ---------- --------KK RIIIGGSSHH ---------A AVFKRRRPTF FYYSSSSPPP KMMMAMMKAA DDDDLAYVAA YYTGRRAADI ---------- -ALKPPPPTF FYYTTTTPPP RDDDAMMRAA DDDDIAYVAA YYVGAAPPDL ---------- -MMRPPPPTF FHHSSSSPPP ELLLAMMQAA EEEEFAYTLL SSPSRRPPDL ---------- -MMRPPPPTF FHHSSSSPPP KLLLAMMEAA NNNNFAYTLL SSPSKKPPDL ---------- -MLRPPPPTF FYYSSSSAAA KLLLAMMEGG KKKKLAFTLL SSPSKKPPDL ---------- -AWKPPPPSF FYYSSSSPPP RLLLAAAKAA TTTTIAYVAA DDPKQQPPDI ---------- -VWRPPPPTF FYYSSSSPPP RMMMAVVKAA KKKKLAYVVV NNPNKKPPDM ---------- -AWRPPPPTF FYYSSSSPPP KMMMAMMQAA RRRRLGYVAA DDPERRPPDL --------AK KT--CCCPGY YPPPPPPLLL EAAAMKK-GG EEEEIVYLPP YYRGAAPPDL ---------- ---------- ---------- -----MM-GG EEEEIVYLPP YYRGAAPPDL RRRLLPGGSQ QG--CCCPGY YPPPPPPLLL EAAAMKK-GG EEEEIVYLPP YYGGAAPPDL ---------- ---------- ---------- ----MKK-GG EEEEIIYLPP YYRGAAPPDL --------AK KG--CCCPGY YSSPPPPLLL EAAAMKK-GG EEEEIVYLPP YYRGAAPPDL QQQMMPIIAK KG--CCCPGY YSSPPPPLLL EAAAMKK-GG EEEEIVYLPP YYRGAAPPDL --------AK KG--CCCPGY YSSPPPPLLL EAAAMKK-GG ---------- ----AAPPDL --------AK KG--CCCPGY YSSPPPPLLL EAAAMKK-GG EEEEIVYLPP YYRGAAPPDL SSSQQWQQAK KG--CCCPGY YPPPPPPQQQ EAAAMKK-GG EEEEIVYLPP YYRGAAPPDL TTTCCLVVPK KG--CCCPGY YSSPPPPLLL EAAAMKK-GG EEEEIVYLPP YYRGAAPPDL --------AK KG--CCCPGY YSSPPPPLLL EAAAMKK-GG EEEEIVYLPP YYRGAAPPDL AAAEEAAAGT TCTAKKKPGY YAAPPPPLLL EAAAMEEKGG KKKKLVYVTT YYNGKKLLDL ---------- ---------- ---------- ---------- ---------- ---------- --------MK KG--CCCPGY YKKPPPPLLL DAAAMKK-GG EEEEIVYLPP YYRGKKPPDL DDDGGVNNSV VGCKSSSPGY YAAPPPPIII ESSSMSS-GG SSSSLIYVTT YYAGKKPPDL QQQAAVSSNQ QGCKSSSPGY YAAPPPPLLL EAAAMSS-GG TTTTLIYVTT YYAGKKPPDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MQVGGGPGY YAAPPPPLLL AAAAMSS-GG KKKKLIYVTT YYTGKKPPDL -----AAAGA ACGATTTPGY YAAPPPPLLL EAAAMEEKGG KKKKLLYVTT YYNGKKPPDL -----MSSGK KH-----PGY YAAPPPPAAA DAAAIKK-GG EEEEVLFVTT ---AGGPPDI -----MPPPK KH-----PGY YAAPPPPAAA DAAAIKK-GG EEEEVLFVTT ---AGGPPDI ---------- ---------- ---------- ---------- ---------- ---------- ---------S SSCKCCCPGY YAAPPPPLLL DAAAVRRNGG KKKKLLYVVV QQPDHHGGDL ---------- ---------- ---------- ----MRRSGG KKKKLLYTVV QQPDHHGGDL ---------- -------PGL LII------- DIIILIISLL FFFFLYFSNN HHGRDDIITR ---LLAGGAG GPRAFFFDET TCCSSSSPPP YMMMPKKITT EEEEFVYVWW GGVMEEQQDL RRRLLSGGAA APGVRRRDET TCCSSSSPPP YMMMKKKITT DDDDYVYVWW GGAVEEQQDL ADVVPPKKSE TTIVHVELLP YIIHFGWACS SAL-N-KKPN NRFLLLLSSS SSSIYYYIII ADVVPPKKSP TTVIYLDLLP YIIHFGWACS SAY-N-KKPF FRYLLLLSSS SSSIYYYIVV ADVVPPGGSS TTIVHVTMMP NTTHFGWACS SSL-LGHHAF FRFLLLLSSS SSSIYYYVII ADVVPPGGSP TTIVHVTMMP NKKHFGWACS SAL-LGHHAF FRYLLLLSSS SSSIYYYIII ADVVPPTTSE KKIVHLIMMP NKKHFGWACS SAL-LGHHAF FRYLLIISSS SSSIYYYIVV ADVVPPAASP RRIVGVAMMP HAAHFGWACS SCL-NPHHPH HRYLLLLSSS SSSIYYYILL CDVVSSQQSS TTVVGTDMMP YTTHFGWACS SML-NPHHPH HRYLLIISSS SSSITTTILL GDLLPPDDSG TTIVGVEMMP NAAHFGWACA AAL-YPHHPH HRYLLIISSS SSSIHHHIVV ADVVPPKKSP QQVIHLPMMP YLLHSGWTCS SC---GDDST TNKLLLLSSS SSSIYYYVVV ADVVPPKKSP HHVIHLPMMP HLLHSGWTCS SC---GDDST TDKLLIISSS SSSIYYYVVV ADIIPPKKSP QQVIHLPMMP NLLHSGWACS SC---GDDST TTKLLLLSSS SSSIYYYVVV ADVVPPKKSP QQVIHLPMMP HLLHSGWTCS SC---GDDIT TTKLLLLSSS SSSIYYYVVV ADVVPPKKSP QQVIHLPMMP NLLHSGWTCS SC---GDDST TTKLLLLSSS SSSIYYYVVV ADVVPPKKSP QQVIE----- ---------- ---------- ---------- ---------- ADVVPPKKSP QQVIHLPMMP NLLHSGWTCS SC---GDDST TTKLLLLSSS SSSIYYYVVV ADVVPPKKSP QQVIHLPMMP NLLHSGWTCS SC---GDDST TTKLLLLSSS SSSIYYYVVV ADVVPPKKSP QQVIHLPMMP YLLHSGWTCS SC---GDDST TNKLLFFSSS SSSIYYYVVV ADVVPPKKSP QQVIHLPMMP NLLHSGWTCS SC---GDDST TTKLLLL--- ---------- ADVVPPKKSP QQVIHLPMMP NLLHSGWTCS SC---GDDST TTKLLLLSSS SSSIYYYVVV ADLLPPSSSP TTVIHLPVVI HIIHSGWSCS SC---GDDPS SRFLLLLSSG GGGVYYYVVV ---------- -------MMP NTTHSGWTCS SC---GDDAS SNKLLLLSSS SSSIYYYVVV ADVVPPKKSP SSVIHLPMMP NVVHSGWTCS SC---GDDSS SNKLLLLSSS SSSIYYYVVV ADVVPPSSSP TTVIHLPVVP YVVHTGWSCS SC---GDDPS SRFLLLLSSG GGGIYYYVII ADLLPPNNSP TTVIHLPVVP YVVHTGWSCS SC---GDDPS SRFLLIISSG GGGVYYYVII ---------- -------MMP FVVHSGWSCS SC---GDDAS SRYLLLLSSG GGGIYYYAII ADVVPPSSSP SSVIHLPMMP FVVHSGWSCS SC---GDDAS SRYLLLLSSG GGGIYYYAII GDVVPPNNSP TTVIHLPVVT HVVHSGWACS SC---GDDPS SRFLLLLSSG GGGVYYYVVV FDVVPPEESD TTVISVDVVP HIIHTGWACS SC---DKKPT TSHLLLLSSD DDDIYYYIII FNVVPPEESE TTIISVDVVP NIIHTGWACS SC---DKKPT TSHLLLLSSD DDDIYYYVII ---------- ---------- ---------- ---------- ---MMLLSSG GGGEGGGKVV ADVVPPAASP TTVIHTYTTN SKKHSGWTCS SCHV-GKKEV VDRLLLLSSD DDDIFFFVII SDVVPPEESP TTIVHTFTTN RKKHSGWACS SCYVESKKTV VDRLLLLSSD DDDIYYYILL KRMMGGQQVF LLVLKGPVVK VLLDSQPPRL LK---GKKRV VPQMMLLGGK KKKLYYYVTT VDLLPPGGSA TTVINVSVVG G--HGGFA-- ---------- -RFFFLLTTN NNNIFFFIFF VDAAPPKKSP QQVVNLSVVG G--HSDFD-- ---------- -RYLLLLTTS SSSIFFFVFF IIITTKPEEP PPPIIIIIKK VPEEEEEEEV KKVSSGYSRL LTHHGDDAYI SGN--EGGEG VVVTTKPRRP PPPVAAAAKK IPEEEVVVVA GGRTTGYTKY YTHHGDDAYI SGG--DGGEG IIITTKPQQA AAAIHHHHKK IPDDDEEEEI AAKTTGYSRP PTHHGEEGYV SGGGGDGGDG IIITTKPKKA AAAIHHHHKK IPEEEEEEEV KKKTTGYSRP PTHHGDDGYV SGGGGDGGNG VVVVVK-KKA AAAIHHHHKK IPEEEEEEEV AAKTTGYSRP PTHHGEEGYV SGGGGDGGDG LLLTTKPKKP PPPLAAAAKK VPEEETTTTL EERTTGYSRP PTHHGGGGYV TGN--EGGKG LLLTTKPQQP PPPVVVVVKK VPNNNEEEEL EERTTGYARP PTHHGDDGYI SGS--EGGEG VVVTTKPEEP PPPIVVVVKK VPEEEEEEEL RRRTTGYSRP PTHHGDDGYV SGS--EGGDG VVVVVGSAAP PPPLHHHHKK VASSSEEEEI AAKCCNVSNT TTHHLSSGVM VLG--LQQNG VVVVVGSAAP PPPLHHHHKK VPNNNEEEEI AAKCCNLGNL LTHHLSSGVM ILG--PQQNG VVVVVGSAAP PPPLHHHHKK VAEEEDDDDI AAKCCGLGYV VTHHLSSGVM ILG--SKKNG VVVVVGTAAP PPPLHHHHKK VPKKKDDDDI TTKCCNLGFF FTHHLSSGVM VLG--PEENG VVVVVGSAAP PPPLHHHHKK VPEEEDDDDI AAKCCELAFL LTHHLSSGVM ILG--VKKNG ---------- ---------- -PKKKDDDDI AAKCCELAFL LTHHLSSGVM ILG--VKKNG VVVVVGSAAP PPPLHHHHKK VPKKKDDDDI AAKCCELAFL LTHHLSSGVM ILG--VKKNG VVVVVGSAAP PPPLHHHHKK VPKKKDDDDI AAKCCELAFL LTHHLSSGVM ILG--VKKNG VVVVVGTAAP PPPLHHHHKK VAKKKDDDDI EEKCCGLGTP PTHHLTTGVM ILG--PKKNG ---------- ---------- ---------- ---------- ---------- ---------- VVVVVGSAAP PPPLHHHHKK VPKKKDDDDI AAKCCELAFL LTHHLSSGVM ILG--VKKNG VVVTTATTTP PPPLHHHHKK VSEEEDDDDI EENIIGLGFP PTHHLSSGIM ILG--KEENA VVVVVGTAAP PPPIHHHHKK TPYYYEEEEV WWKCCGLANL LTHHLCCGIM IIG--PYYNG VVVVVGSAAP PPPIHHHHKK TPYYYEEEEV WWKCCGLANP PTHHLCCGIM ILG--PCCNG IIITTKTSSP PPPLHHHHKK VPAAADDDDI QQKTTGLAYP PTHHLSSGLM ILG--KDDNA IIITTKTAAP PPPLHHHHKK VPEEEDDDDI TTKTTGLAYP PTHHLSSGIM IIG--KDDNA IIITTKEAAP PPPLYYYYKK YPKKKEEEEI EEKTTGLAYP PTHHLSSGIL VLG--EEENA IIITTKEAAP PPPLYYYYKK YPKKKEEEEI DDKTTGLAFP PTHHR--GIL VLG--EEENA VVVTTLKAAP PPPLHHHHKK VAEEEDDDDI EEKTTGLGFP PTHHLSSGIM ILG--KEENA IIIVVENKKI IIILEEEEHH TPSSSKKKKL SSLNN-LSFP PTHHLDDGIM ILG--ANNTP IIIVVENEEI IIILQQQQHH TPSSSKKKKL AALNN-LSFP PTHHLDDGIM ILG--ADDSP VVVVVGG--- ---------- ---------- ---------- ---------- ---------- IIITTGTAAP PPPLAAAAKK VG---DDDDV KKGAADCTAP PTHHLNNGIM IMG--AEENA LLLVVVTKKP PPPIVVVVKK TG---DDDDV KKSHHNVTAP PTHHLNNGIM IMG--AEEYA TTTSSLYDDK KKKFYYYYPP -----DDDDL KKFLLVLAIS STDDQNNTLK QVN--SLLVP FFFVVHSNNP PPPLHHHHKK TT---FFFFV DDSGGGVVGP PTFFLGGSMI TSN--DDDGG FFFVVHSRRP PPPLSSSSKK TD---FFFFV KKSGGGVVGP PTYYLGGRLI TSN--KDDGG GGILLMLLLD DYEEEELLER D--------- ---------- YYYYYDDFFW WWLL--NEVV GGIFFLLLLD DDEEEEIIER P--------- ---------- YYYYYDDFFW WWLL--SGVI GGIFFIMMMD DEDDDDLLER P--------- ---------- YYYYYDDFFW WWLL--RDYV GGVFFIMMMD DEEEEELLER P--------- ---------- YYYYYDDFFW WWLL--RDYV GGIFFILLLD DEEEEELLER E--------- ---------- YYYYYDDFFW WWLL--RDYV GGIAAMLLLD DQEEEELLER P--------- ---------- YYYYYDDGGW WWLL--YDTV GGIFFILLLD DDEEEELLER D--------- ---------- YYYYYDDFFW WWLL--YDTL GGVFFVMMMD DEDDDDLLER P--------- ---------- YYYYYDDFFW WWLL--YDTV SSFVVLLLLD DEEEEEKKEG A--------- ---------- YYYYYDDFFW WWPP--HNVV GGFVVLLLLD DEEEEEKKEG E--------- ---------- YYYYYDDFFW WWPP--HNIV GGFVVLLLLD DEEEEEKKEG A--------- ---------- YYYYYDDFFW WWPP--HNVI GGFVVLLLLD DKEEEEKKEG A--------- ---------- YYYYYDDFFW WWPP--HNVI GGFVVLLLLD DEEEEEKKEG A--------- ---------- YYYYYDDFFW WWPP--HNVI GGFVVLLLLD DEEEEEKKEG A--------- ---------- YYYYYDDFFW WWPP--HNVI GGFVVLLLLD DEEEEEKKEG A--------- ---------- YYYYYDDFFW WWPP--HNVI GGFVVLLLLD DEEEEEKKEG A--------- ---------- YYYYYDDFFW WWPP--HNVI GGFVVLLLLD DEEEEEKKEG S--------- ---------- YYYYYDDFFW WWPP--HNVI ---------- ---------- ---------- ---------- ---------- ---------- GGSLLVLLLL L-EEEESS-- ---------- ---------- ---------- ---------- NNGFFLLLLL LSNNNNKKSL P--------- ---------- RRRRRTTHHL LLNNYYWGLW GGFVVLLLLD DEEEEEKKEG A--------- ---------- YYYYYDDFFW WWPP--HNVI GGFVVLLLLD DEEEEEKKEG S--------- ---------- YYYYYDDFFW WWPP--HNVI NNGFFLLLLL LSNNNNKKEG S--------- ---------- YYYYYDDFFW WWPP--HNTI NNGFFLLLLL LSNNNNKKEG S--------- ---------- YYYYYDDFFW WWPP--HNTI NNGFFLLLLL LSNNNNKKEG S--------- ---------- YYYYYDDFFW WWPP--HKTI NNGLLLLLLL LSNNNNKKED S--------- ---------- YYYYYHHFFW WWPP--HKTI NNGFFLLLLL LSNNNNKKEG S--------- ---------- YYYYYDDYYW WWPP--HKTI NNFLLLLLLD DKEEEEKKPE T--------- ---------- YYYYYDDFFW WWPP--RNVI NNFLLLLLLD DKEEEEKKPG V--------- ---------- YYYYYDDFFW WWPP--RNII ---------- ---------- ---------- ---------- ---------- ---------- --DFFVEEEF FKEEEEVVSD K--------- ---------- YYYYYDDYYW WWPP--FNVV --DFFILLLF FSNNNNIITD K--------- ---------- YYYYYDDFFW WWPP--FDVV NNGIIQTTTS SHGGGGSSEQ E--------- ---------- LLLLLSSNNH HHGG--REKE AALVVEYYYN NDYYYYAAMA DGAAAAVVVG GDDAAVAADG YYYYYDDIIR RRII--KNVL AALVVEYYYT TAYYYYAAID DGAAAKTTTG G--KKYAADG YYYYYDDVVR RRPP--KNLV SSSEAAPNNN -TIIIEEDD- LLELKDDDD- RRYYYGNNNF FWDDRKRRRI IIIHHHSSLT SSSETTPRRR -CFFFEEEE- FLELKEEEEG AAYYYGNNNV VWDDAKRRHL LLLYYYAAID SSSEAAPPPP -QFFFEENN- IPELLAAAAN KKYYYGHHHF FWDDRARRNV VVVQQQTTID SSSEAAPPPP -QFFFEENN- IPELLSSSSN KKYYYGHHHF FWDDRARRNV VVVQQQTTID SSSEGGPPPP -QFFFEENN- IPELLSSSSN KKYYYGHHHF FWKKRDRRNV VVVQQQTTID SSSEGGPDDD -MVVVEEDD- LPDLLGGGGA RRYYYGRRRF FWDDTRRRHL LLLQQQEEID SSSEGGPRRR -MVVVEESS- VGDLLAAAAG KKYYYGHHHV VWDDYRRRHL LLLQQQTTLD SSSEGGPNNN -MIIIEEGG- LPQLLNNNNK GGYYYGRRRI IWDDRRRRHL LLLQQQAALD TTTEAAPNNN -VFFFKKDDF NAHEA----G LLYYYGSSSV VWDDQRHHII IIIQQQTTLQ TTTEAAPNNN -VFFFKKDDF NAHEA----G LLYYYGSSSV VWDDQRHHII IIIQQQTTLQ TTTEAAPNNN -VFFFRRDDF NADEA----G LLYYYGSSSV VWDDQRHHII IIIQQQTTLT TTTEAAPNNN -VLLLRRDDF NADKA----G LLYYYGSSSV VWDDQRRRIV VVVQQQTTLP TTTEAAPNNN -VLLLRRDDF NADEA----G LLYYYGSSSV VWDDQHHHIV VVVQQQTTLS TTTEAAPNNN -VLLLRRDDF NADEA----G LLYYYGSSSV VWDDQRHHIV VVVQQQTTLS TTTEAAPNNN -VLLLRRDDF NADEA----G LLYYYGSSSV VWDDQRHHIV VVVQQQTTLS TTTEAAPNNN -VLLLRRDDF NADEA----G LLYYYGSSSV VWDDQRHHIV VVVQQQTTLS TTTEAAPNNN -VVVVQQNNF NADEA----G LLYYYGKKKV VWDDQRHHIV VVVQQQTTLL ---------- ---------- ---------- ---------- ---------- ---------- AAAIAASNNN -LRRRLLTTS RYPSA----S RRVVVAGGG- ---------- ---------- WWWICCSLLL -FYYYTTTTA EMCTA----S GGVVVHVVVL LDNNIMRRID DDDEEESSLP TTTEGGPKKK -AFFFAALLF KEEQA----G MMYYYGHHHV VWDDTEHHRI IIIQQQTTID TTTEGGPKKK -AFFFAALLF KEDQA----G HHYYYGHHHV VWDDTEHHLV VVVQQQTTID TTTSGGPTTT -AFFFTTKKF DQHAD----G LLYYYGRRRC CIQQARGGLR RRRQQQTTLD TTTSGGPKKK -AFFFLLQQF NQHAD----G LLYYYGRRRV VYSSPGGGIK KKKQQQTTLD TTTSGGPKKK -AFFFSSKKF DQHAD----G LLYYYGSSSV VYSSPGGGMK KKKQQQLLID TTTSGGPKKK -AFFFSSKKF NQHAD----G LLYYYGSSSV VYSSPGGGIK KKKQQQLLID SSSSGGPAAA -AFFFRRTTF DQHQD----G LLYYYGRRRV VYDDPGGGLK KKKQQQTTLD TTTEGGPNNN -HIIIKKKKF NAHGE----G LLYYYGNNNI IFEEDSKKYL LLLQQQTTID TTTEGGPNNN -HIIIKKKKF NAHPE----G LLYYYGNNNI IFEEDTKKHL LLLQQQTTID IIILGGPVVV -TVVVCCRRE EKCPE----P LLVVVIKKKV VY-------- ---------- SSSEGGPKKK -LFFFRRRRY HTDDDRRRRT QQYYYGCCCF FYRRQERRLF FFFQQQTTID SSSEGGPNNN -KWWWRRRRW KVDEDMMMMS QQYYYGCCCF FYKKSTQQLY YYYQQQTTID DDDRDDPIII -MAAAFFEES EFLKTGGGGP LLKKKPQQQE EVLL------ ---------- SSSSTTWSSS YMMMMDDFFQ MQDEAMMMMK RRFFFGNNNQ QWDDHTRRPK KKKKKKVVFN SSSSTTWNNN YMMMMDDFFK MADEAMMMMK HHFFFGNNNT TWDDHTKKPK KKKKKKVVFD RAAL--LLRL LLHDPTMMVV VSSLDDLLSS WWWWLLWWFY ---DKKKWWE EIPAAAAEPP RVVL--VVRL LLHDPTVVVV LNNTDDLLSS WWWWLLWWFY ---DKKKWWE EIEAAAAQPP QAAL--VVRA AAHDPVVVVV VDDTNNLLSS WWWWTTWWWR ---GKKKFFK KIPAAAAEPP QAAL--VVRA AAHDPVVVVV VDDTNNLLSS WWWWTTWWWR ---GKKKFFE EIPPPPPEPP QAAL--IIRA AAHDPSVVVV VDDTNNLLAA FFFFTTWWWQ KKKDTTTFFK KIDPPPPVPP QVVF--LLRA AAHDPTCCVV ISSLDDLLSS WWWWTTWWYR ---KKKKWWR RIPAAAAEAA QAAL--LLRA AAHDPTCCVV VSSLDDLLSS WWWWLLWWYR ---NSSSWWK KIPAAAAEPP QVVL--LLRA AAHDPAVVVV VSSLDDLLSS WWWWLLWWHR ---NSSSWWR RIPAAAAEPP GIIPLLIIRL LLHDPSCCAA LSSSIIQQYY NNNNEEEEG- ---------- -SVEEEEKVV GIIPLLIIRL LLHDPDCCAA LSSSIIQQYY NNNNEEGGG- ---------- -SVEEEEKVV GIIPLLIIRL LLHNPDCCAA LSSSIIQQYY NNNNQQGGG- ---------- -SVEEEEKVV GIIPLLIIRL LLHNPDCCAA LSSSIIQQFF NNNNEEDDG- ---------- -SAQQQQKVV GIIPLLIIRL LLHNPDCCAA LSSSIIQQYY NNNNEEGGG- ---------- -SVEEEEKVV GIIPLLIIRL LLHNPDCCAA LSSSIIQQYY NNNNEEGGG- ---------- -SVEEEEKVV GIIPLLIIRL LLHNPDCCAA LSSSIIQQYY NNNNEEGGG- ---------- -SVEEEEKVV GIIPLLIIRL LLHNPDCCAA LSSSIIQQYY NNNNEEGGG- ---------- -SVEEEEKVV GIIPLLIIRL LLHDPACCAA LSSSIIQQYY NNNNEEGGG- ---------- -SVEEEEKVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QGGALLLLRI IIHWKNVVEE VSSFGGRRSS PPPPDDAAY- ---------- -VLKKKKRKK GIIPLLIIRL LLHDPDCCAA LSSSVVFFYY EEEEKKDDG- ---------- -AAEEEEKVV GIIPLLIIRL LLHNPDCCAA LSSSIIFFYY EEEEKKDDG- ---------- -AAEEEEKVV GLLPLLIIRL LLHDPASSAA LSSSMMIIFF TTTTQQDDG- ---------- -SHEEEELAA GLLPLLIIRL LLHDPASSAA LTTSMMIIFF TTTTQQDDG- ---------- -NHEEEEIVV GLLPLLIIRL LLHDPSSSAA LSSSMMIIFF NNNNSSDDD- ---------- -SYEEEEIVV GLLPLLIIRL LLHDPSSSAA LSSSMMIIFF NNNNSSDDE- ---------- -SHEEEEVVV GLLPLLVVRL LLHDPSCCAA LTTSMMVVFF TTTTAADDG- ---------- -SHEEEEVAA GLLPLLVVRL LLHEPTCCAA LGGSIIFFHH VVVVEEEENS ---------- -AATTTTLVV GLLPLLVVRL LLHEPTCCAA LGGSIIFFHH DDDDEEKKNP ---------- -TASSSSLVV ---------- ---------- ---------- ---------- ---------- ---------- GTTPLLIIRL LLHNPRCCAA FXXXXXXXXX ---------- ---------- ---------- GTTPLLIIRL LLHNPKCCAA LNNAVVFFKK KKKKSSDDSD ---------- -KKVVVVIDD ---------- ---------- ---------- ---------- ---------- ---------- ----LLIIRP PPWGSNTTAA LTTSLLWWYY DDDDDDAAG- ---------- ---------- ----LLIIRA AAWGEATTAA LTTSLLWWYY DDDDGGEEG- ---------- ---------- PEEGPEILLF KKKAAAAPLL VTDDDLDKKL YYLLGGIGGG EVVVRDSNNP KPPVVLTKVF PEEGPPVLLF KKKMMMMPLL VTDDDLDRRL YYLLGGLGGG ELLLRDTNNP QPPRRLARVY PTTAPPLLLF GGGAAAAPLL VTDDDLDRRL YYCCGGTGGG EMMMRDSDDP NPPVVLASVA PPPKPPLLLF GGGAAAAPLL VTDDDMDRRL YYCCGGTGGG EMMMRDSDDP KPPKKLASVA PDDAPDLLLF GGGAAAAPLL VTDDDLDKKL YYCCGGLGGG EMMMHDSDDP NPPVVLTKVV ADDPPPVLLF KKKAAAAPLL VTDDDMDRRL YYCCGGTGGG DLLLLDSDDP EPPKKLTKVV PSSEPPILLF KKKAAAAPLL VTDNNVDRRL YYCCGGTGGG ELLLHDSDDP NPPRRLTKVV PEEPPPLLLF GGGAAAAPLL VTDNNLDRRL YYCCGGTGGG ELLLRDSDDP NPPRRHTSVV VQQVKVKGGL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DIIIRDSNNP KPPRRLTQII VQQVKVKGGL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DIIIRDSNNP KPPRRLTQII VQQVKVKGGL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DLLLRDSDDP RPPRRLTQLI VQQVKVKGGL PPPEEEEGLL ITDLLLDHHL YYNNLLHGGG DIIIRDSDDP RPPRRLTQLI VQQVKVKGGL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DLLLRDSDDP RPPRRLTQLI VQQVKVKGGL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DLLLRDSDDP RPPRRL---- VQQVKVKGGL PPPEEEEGLL IT-------- ---------- ---------- ---------- VQQVKVKGGL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DLLLRDSDDP RPPRRLTQLI VEEVKVKGGL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DMMMRDSDDP RPPRRLVQII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KDDLVVAKKV VVVSSSSNEE FPPWWFDLLI IISS------ ---------- ---------- VKKVKVEGGL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DIIIRDTDDP NPPKKLVQII VQQVKVEGGM PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DIIIRDTDDT NPPKKLVQII APPVKVQNNL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DIIIRNEDDL NPPVVLTQLI VSSVKVQNNL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DIIIRNEDDV NPPKKLTQVI VSSVKVENNL PPPEEEEGLL ITDLLLDRRL YYNNLLHGGG DIIIRNEDDP NPPVVLTQIL VSSVKVENNL PPPEEEEGLL ITDLLLDRRI YYNNLLHGGG DIIIRNEDDP NPPVVLTQIL ASSIKVRNNL PPPEEEEGLL ITDVVLDRRL YYNNLLHGGG DIIIRNEDDP KPPVVLAQVL VFFIKVSGGL PPPEEEEALL ITDLLMDRRL YYCCLLHGGG DIIIRDSDDP KVVKKLNQVV VTTIKVENNL PPPDDDDALL ITDLLMDRRL YYCCLLHGGG DIIIRDSDDP NPPKKLNQVI ---------- ---------- ---------- ---------- ---------- ---------- ----QGENNI EEEMMMMGMM MTDLLLDRRL YYNNRRHGGG DVVVRDSDDR NPPRRLTQVI DPPGDTGSSA EEEDDDDGMM ISDIILDRRL YYCCRRHGGG DVVVRDTDDP NPPKKLTQLI ---------- ---------- ---------- ---------- ---------- ---------- -EEWAVADDN PPPAAAAPLL PVDSSADQQL WWSSMMDGGG KTTTRDSDDP KPPFFQIEKV -EEWAVADDE PPPAAAAPLL PVDSSNDSSL WWTTMMDGGG KTTTRDSDDP HPPRRQVEKV HRRRADHP-- ---------- ----HHKLTA APQEIISRGG RRRRTNNNSY WNFYYEEKGG HRRREPHP-- ---------- ----AAEATA APQSVVSRGG RRRRTNNNSY WNFYY--RGG RRRRAPHP-- ---------- ----RRTFAG GPQEIISRGG RRRRTNNNSY WDFYYDDPAA RRRRTPHP-- ---------- ----KKAFAG GPQEIISRGG RRRRTNNNSY WDFYYDDPGG KKKKTPHP-- ---------- ----KKTFGG GPQEIISRGG KKRRTNNNSY WEFYYGGGAA SRRRATHPGG ---------- ----GGALNG GPQEIISRGG RRRRTNNNSY VPFYYEEDGG RRRRAGHP-- ---------- ----AAELNG GPQEIISRGG RRRRTNNNSY WEFYYDDKGG RKKKAAHP-- ---------- ----GGPLNG GPQEVVSRGG RRRRSNNNSY WEFYYVVRGG VRRRGGSVQQ VLELLLCQQP EVVVKKRIPG GPQQLLSLGG KKRRTTTTSY WKFYYPPIRR VKKKGGSVQQ VLELLLCQQP EVVVKKRVPG GPQQLLSLGG KKRRTTTTSY WKFYYPPIRR VKKKGGPVQQ VLELLLSQQP EVVVKKKVPG GPQQLLSLGG KKRRTTTTSY WKFYYPPIRR VKKKDGPVQQ VLELLLSQQP EVVVKKQVAG GPQQLLSLGG KKRRTTTTSY WKFYYPPIRR VKKKGGPVQQ VLELLLSQQP EVVVKKRVAG GPQQLLSLGG KKRRTTTTSY WKFYYPPIRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VKKKGGPVQQ VLELLLSQQP EVVVKKRVAG GPQQLLSLGG KKRRTTTTSY WKFYYPPIRR VKKKGGPVQQ VLELLLSQQP EVVVKKRVPG GPQQLLSLGG KKRRTTTTSY WKFYYPPIRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LRRRGGPVTT VLDLLLCQQP DIIIKKKVPG GPQQLLSLGG KKRRTNNNSY WKFYYPPIKK QRRRGGPVTT VLELLLCQQP DTTTKKIIPG GPQQLLSLGG KKRRTSSSSY WKFYYPPLKK QKKKGSPVAA AIGKKKWQQS DEEEQQKLRG GPQQLLTLGG KKRRTNNNSF WKFYYPPVEE QKKKGSPVVV AVGEEEWQQS DEEEKKKLRG GPQQLLSLGG KKRRTNNNSF WKFYYPPVEE QKKKGSPVKK AVGNNNFQQF DQQQKKSLRG GPQQLLSLGG KKRRTNNNSF WRFYYPPMDD QKKKGSPVKK AVGNNNFQQF EQQQKKSLRG GPQQLLSLGG KKRRTNNNSF WVFYYPPMEE QKKKGSEVVV YVDKKKEQQY SQQQHHRLRG GPQQLLSLGG KKRRTNNNSF WEFYYQQVKK HTTTESNVKK VLK----PPI EYYYRRKIEG GPQQLLSLGG KKRRTTTTSY WDFYYPPVKK HSSSETTVKK VLHDDD-EEI PYYYRRQIEG GPQQLLSLGG KKRRSTTTSY WDFYYPPVRR ---------- ---------- ---------G GPAQLLSVGG KKRRTNNNSY WKFYYPPVKK QRRRDAPRRR VLELLLEAAP EFFFRRRLLG GPQQLLSLGG RRRRSSSSSF WKFYYPPVAA CSSSDLPNVV IVELLLERRP PYYYRRRLEG GPQQLLSLGG KKRRSSSSSY WKFYYPPVSS ---------- ---------- ---------- ---------- ---------- ---------- N--------- ---------- ---------- ---SQQSWGG KKRRSSSSSL W-------KK N--------- ---------- ---------- ---SSSSWGG QQRRTSSSSL W-------KK MVLAAAA--- -PPSSSGGGG GEEEEEFFFV DE-----AAA RRRSHLSSSS GDSDSSSCP- MAVVVVV--- -PPEEEGGGG GEEEEEFFFV DR-----AAA RRRAHLWWWW GDSDSSSCP- QVAAAAA--- -PPDDDGGGG GTTDDDYYWV EDG----YYY RRRAHLEEEE GDSDSSSCPS EVAVVVV--- -GGNNNGGGG GEEDDDYYFV SDG----YYY RRRAHLEEEE GDSDSSSCPS MVAVVVV--- -EENNNGGGG GTTDDDFFWV DAG----YYY RRRSHLEEEE GDSDSSSCPS MVLAAAA--- -PPNNNGGGG GEEKKKFFFL EKG----HHH RRRPHLQQQQ GDSDSSSCP- MVVVVVV--- -PPDDDGGGG GQQNNNFFFV DE-----QQQ RRRVHLQQQQ GDSDSSSCP- IAAAAAA--- -PPGGGGGGG GSSGGGFFFT EDG----LLL RRRPHLEEEE GDSDSSSCPS GSMQQQQDVD TVVNNNGGGG GKKNNNFFLV DKEPPPGAAA LLLAHYPPPP GDSDIIII-- GSMQQQQDVD TAANNNGGGG GKKNNNFFLV DKEPPPGAAA LLLAHYPPPP GDSDIIII-- GSMQQQQDVD TVVKKKGGGG GKKNNNFFLV DKEPPPGAAA LLLAHYPPPP GDSDIIIL-- GSMQQQQDVD TVVKKKGGGG GTTNNNFFLV DKEPPPGAAA LLLAHYPPPP GDSDIIIL-- GSMQQQQDVD TVVKKKGGGG GKKNNNFFLV DKEPPPGAAA LLLAHYPPPP GDSDIIII-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSMQQQQDVD TVVKKKGGGG GKKNNNFFLV DKEPPPGAAA LLLAHYPPPP GDSDIIII-- GSMQQQQDVD TVVKKKGGGG GKKNNNFFLV DKEPPPGAAA LLLAHYPPPP GDTDIIIL-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSMQQQQDVD TEEKKKGGGG GKKNNNFFLV DKEPPPGVVV LLLAHYPPPP GDSDIIIV-- GAMQQQQDVD TKKKKKGGGG GKKNNNFFLV DKEPPPGVVV LLLAHYPPPP GDTDIIII-- GSIQQQQDVD TEEKKKGGGG GKKNNNFFFV DAEPPPGAAA LLLAHYPPPP GDTDIIII-- GSIQQQQDVD TEENNNGGGG GKKNNNFFFV DAEPPPGSSS LLLAHYPPPP GDTDIIII-- GSIQQQQDVD TEEKKKGGGG GSSNNNFFFV DDEPPPGAAA LLLAHYPPPP GDTDIIII-- GSIQQQQDGD TEEKKKGGGG GTTDDDFFFV DDEPPPGSSS LLLAHYPPPP GDTDIIII-- GSMQQQQDVD TEEKKKGGGG GSSNNNFFFV DAEPPPGSSS LLLAHYPPPP GDTDIIII-- GAMQQQQNID PEESSSGGKK KEEDDDFFLI DKIEEEGYYY LLLAHYPPPP GDTDIIII-- GAMQQQQDVD PIITTTGGHH HVVNNNFFLI DKVPPPGYYY LLLAHYPPPP GDTDIIII-- GSMQQQQDVD TEEKKKGGGG GTTNNNFFLV DKEPPPGCCC LLLAHFPPPP GDTDIIIA-- GGIQQQQDID VEENNNGGGG GKKNNNFFLV DGEPPPGGGG LLLPH----- ---------- GGILLLLDVD TVVNNNGGGG GSSDDDFFLV DNEPPPGSSS LLLPHYPPPP GDTDIIILND ---------- ---------- ---------- ---------- ---------- ---------- GKDQQQQLKA YNNWWWDDGG GEEDDDFFAV DELGGGG--- RRRAHFGGGG SAYS------ GKDQQQQLKL YYYWWWDDGG GEEQQQFFAI DAEKKKG--- RRRPHFGGGG RAYGPPPGGN ------- ------- VRR---- V------ V------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- A------ ------- ------- RVVAVVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158SSAKKPPSSS ETPCRRTTAT GGLALLAADG MQQQSSLTLL LLLLLLLLTT PPGPPVRRRK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YQEAWFSSSA IVVLPPRRGR RKKTSSVPVA AAAVQQVAVV QQWHWLPPGG GKHHGAALAP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------EERR RAEEGAFLSV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MGLKKEE EEPPGHTQWF ---------- ---------- ---------- ---------- --LKNSGGCC CLGGFDQNEL ---------- ---------- ---------- ---------- ---------- ---------- MAGSATPPPP LNNRPPHHAP PAASPPHPPV VVVRRRTPLL PPCPHAHHSS SLVVLQHMGA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MTV ---------- ---------- ---------- ---------- ---------- -------MTV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MRRRR REFFG----- ---------- ---------- ---------- ---------- -----MRRFF FIVVSGPMFA --------MA AIVPFKKPPT TFFFPPKKMA AKAAPPEDYV CYGRAFIAAV DDPKKSSYSI ---------- -MAKLKKPPT TFFFPPRRDA ARAAPPEDYV AYGAPFLAAV DDPKKSSYGV ---------- --MSMRRPPT TFFFAAEELA AQAAPPEEYT LSSRPALAAI DDPGGSSYGI ---------- --MTMRRPPT TFFFAAKKLA AEAAPPENYT LSSKPALAAI DDPGGSSYGI ---------- --MTLRRPPT TFFFPPKKLA AEGGPPEKFT MSSKPGLAAV DDPTTSSFGI ---------- -MATWKKPPS SFFFPPRRLA AKAAPPETYV MDKQPAIAAV DDPAASSYAI ---------- -MVTWRRPPT TFFFPPRRMA AKAAPPEKYV RNNKPAMCCV DDSQQSSFGV ---------- -MASWRRPPT TFFFPPKKMA AQAAPPERYV LDERPALGGL DDPDDSSYAI -------MTK KCTK---PPG GYYYTTEEAM M-GGPPEEYL CYGAPYLAAV DDPKKSSYSV ---------- ---------- ---------- --GGPPEEYL CYGAPYLAAV DDPKKSSYSV PGLLPAAHTQ QCGK---PPG GYYYSSEEAM M-GGPPEEYL CYGAPYLAAV DDPKKSSYCV ---------- ---------- ---------M M-GGPPEEYL CYGAPYLAAV DDPKKSSYCV -------MTK KCGN---PPG GYYYTTEEAM M-GGPPEEYL CYGAPYLAAV DDPKKSSYCV VPMRPSSTTK KCGN---PPG GYYYTTEEAM M-GGPPEEYL CYGAPYLAAV DDPKKSSYCV -------MTK KCGN---PPG GYYYTTEEAM M-GG------ ---APYLAAV DDPKKSSYCV -------MTK KCGN---PPG GYYYTTEEAM M-GGPPEEYL CYGAPYLAAV DDPKKSSYCV FGQLWDDTTK KCGD---PPG GYYYTTEEAM M-GGPPEEYL CYGAPYLAAV DDPKKSSYSV LYCTLTTSTK KCGN---PPG GYYYTTEEAM M-GGPPEEYL CYGAPYLAAV DDPKKSSYCV -------MTK KCGN---PPG GYYYTTEEAM M-GGPPEEYL CYGAPYLAAV DDPKKSSYCV AVETAAANKT TCCHTAAPPG GYYYTTEEAM MKGGPPEKYV CYGKLYLAAV DDPSSSSYSV ---------- ---------- ---------- ---------- ---------- ---------- --------AK KCGS---PPG GYYYSSDDAM M-GGPPEEYL CYGKPYLAAV DDPKKSSYSV VHGVVKKK-V VNGCCKKPPG GYYYSSEESM M-GGPPESYV AYGKPYLAAV DDPSSSSYSV VHAVVKKVNQ QQGCCKKPPG GYYYSSEEAM M-GGPPETYV AYGKPYLAAV DDPNNSSYSV ---------- ---------- ---------- ---------- ---------- ---------- ---------- -RMLQVVPPG GYYYTTAAAM M-GGPPEKYV AYGKPYLAAV DDPSSSSYSV ---MAAANAA ACCGGAAPPG GYYYTTEEAM MKGGPPEKYV CYGKPYLGGV DDPNNSSYSV ----MNNCLK KCHG---PPG GYYYSSDDAI I-GGPPEEFV A-AGPAIFFV DDPEESSFCV ----M--CLK KCHG---PPG GYYYSSDDAI I-GGPPEEFV A-AGPAIFFV NNPEESSFCI ---------- ---------- ---------- ---------- ---------- ---------- --------MS SESKCKKPPG GYYYTTDDAV VNGGPPEKYV CQDHGYLAAV DDPAASSYCV ---------- ---------- ---------M MSGGPPEKYT TQDHGYLSSV DDPEESSYCI ---------- -------PPG GLLLTTDDIL LSLLDDRFFS WHRDIDRKKP RRGQQVVGGV -ALAAAALMG GLPFRAADDE ETTTQQYYMP PITTGGEEYV TGMEQKLVVI DDPGGSSRGV AALVSAALLA AAPAGVVDDE ETTTAAYYMK KITTGGEDYV TGVEQKLVVV DDPKKSSYGV HKVEDDEELH FGGWWWWCCS SSSSALLPPN NG-KKNIERR FRRRSSRRYY IDTKKNPPPE YKLDDDEELH FGGWWWWCCS SSSSAYYPPN NA-KKFLERR YRRRSSRRYY VDTKKDKKKR HTVTDDEEFH FGGWWWWCCS SSSSSLLPPL LTGHHFLERR FRRRSSRRYY IDTKKHPPPQ HTVTDDEEFH FGGWWWWCCS SSSSALLPPL LAGHHFIERR YRRRSSRRYY IDTKKDPPPK HQLIDDEEFH FGGWWWWCCS SSSSALLPPL LTGHHFLERR YRRRSSRRYY VDVKKEPPPK GQVADDEELH FGGWWWWCCS SSSSCLLPPN NAPHHHMERR YRRRSSRRYY LDTKKDPPPK GVTDGGEELH FGGWWWWCCS SSSSMLLPPN NAPHHHVERR YRRRSSHHTT LDTKKDPPPQ GRVEDDEELH FGGWWWWCCS SSSAALLPPY YAPHHHVERR YRRRSSRRHH VDTKKDPPPE HRLPDDEELH SGGWWWWCCS SSSSC----- -FGDDTKSRN KMMMSSRRYY VDVGGEPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -FGDDTKSRD KIIISSRRYY VDVGGEPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -FGDDTKSRT KMMMSSRRYY VDVGGDPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -YGDDTKART KIIISSRRYY VDVGGEPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -FGDDTKSRT KIIISSRRYY VDVGGEPPPA E--------- ---------- ---------- ---------- ---------- ---------- HRLPDDEELH SGGWWWWCCS SSSSC----- -FGDDTKSRT KIIISSRRYY VDVGGEPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -FGDDTKSRT KIIISSRRYY VDVGGEPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -FGDDTKSRN KIIISSRRYY VDVGGEPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -FGDDTKSRT K--------- ---------- HRLPDDEELH SGGWWWWCCS SSSSC----- -FGDDTKSRT KIIISSRRYY VDVGGEPPPA HRLPDDKKLH SGGWWWWCCS SSSSC----- -HGDDSAKRR FLLLSSRRYY VDTAADPPPT ----DDEELH SGGWWWWCCS SSSSC----- -YGDDSKVRN KIIISSRRYY VDVGGDPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -YGDDSKVRN KIIISSRRYY VDVGGDPPPA HRLPDDEELH TGGWWWWCCS SSSSC----- -HGDDSAERR FVVVSSRRYY IDTKKNPPPS HRLPDDEELH TGGWWWWCCS SSSSC----- -HGDDSAQRR FVVVSSRRYY IDTKKNPPPA ----DDEELH SGGWWWWCCS SSSSC----- -HGDDSADRR YIIISSRRYY IDTKKNPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -HGDDSVDRR YIIISSRRYY IDTKKNPPPA HRLPDDEELH SGGWWWWCCS SSSSC----- -HGDDSASRR FLLLSSRRYY VDTLLDPPPA SRVDDDEEVH TGGWWWWCCS SSSSC----- -HDKKTEKRS HNNNSSRRYY INVEEE---K SRVDDDEEVH TGGWWWWCCS SSSSC----- -HDKKTEKRS HNNNSSRRYY INVEEE---E ---------- ---------- ---------- ---------- -SSSSSVVGG VFVGG----- HRTYNNEELH SGGWWWWCCS SSSSCHHPP- -GGKKVPTRD RNNNSSRRFF IDTGGDPPPA HRTFDDEELH SGGWWWWCCS SSSSCYYDDE ESSKKVPKRD RNNNSSFFYY LDVVVDPPPK KDGPDDKKEL SQQPPPPRRI IIILK----- --GKKVQGGP QDDDGGRRYY TTSLLSAAAD NSVSNNEEAH GGGFFFF--- ---------- -------DRR FDDDTTRRFF FDVHHDPPPN NTLSNNEEAH SDDFFFF--- ---------- -------DRR YDDDTTKKFF FDVHHDPPPR EKKIIIIIKK VIIEEEPEEE EVSSGRTHCG DAIIIYSSAA GNEEEE-EEE GPMLHFELLL RAAVVAAAKK IVVEEEPEEV VATTGKTHCG DAIIIYSSAA GGPPPDREEE GPLLHFEIII QRRIIHHHKK IIIEEEPDDE EITTGRTHCG EGIIIYSSTT GGAAADTDDD GAIMCFDLLL KKKIIHHHKK IIIEEEPEEE EVTTGRTHCG DGIIIYSSTT GGGGGDTNNN GPIMCFELLL KKKIIHHHKK IIIEEEPEEE EVTTGRTHCG EGIIIYSSTT GGGGGDTDDD GPILCFELLL KFFLLAAAKK VIIEEEPEET TLTTGRTHCG GGIIIYTTAA GNAAAE-KKK GPMLAFELLL QKKVVVVVKK VIIDDDPNNE ELTTGRTHCG DGIIIYSSAA GSPPPE-EEE GPILHLELLL ERRIIVVVKK VIIEEEPEEE ELTTGRTHCG DGVVVYSSAA GSPPPE-DDD GPVMHFDLLL AKKLLHHHKK VIIEEEASSE EICCNNTHCL SGEEEVVVNN LGDDDLGNNN GKLLGFEKKK AKKLLHHHKK VIIEEEPNNE EICCNNTHCL SGEEEVIISS LGDDDPGNNN GKLLGFEKKK AKKLLHHHKK VIIEEEAEED DICCGYTHCL SGEEEVIISS LGDDDSGNNN GKLLGFEKKK AKKLLHHHKK VIIEEEPKKD DICCNFTHCL SGEEEVVVSS LGDDDPGNNN GKLLGFEKKK AKKLLHHHKK VIIEEEPEED DICCEFTHCL SGEEEVIISS LGDDDVGNNN GKLLGFEKKK ---------- ------PKKD DICCEFTHCL SGEEEVIISS LGDDDVGNNN GKLLGFEKKK AKKLLHHHKK VIIEEEPKKD DICCEFTHCL SGEEEVIISS LGDDDVGNNN GKLLGFEKKK AKKLLHHHKK VIIEEEPKKD DICCEFTHCL SGEEEVIISS LGDDDVGNNN GKLLGFEKKK AKKLLHHHKK VIIEEEAKKD DICCGTTHCL TGEEEVIISS LGDDDPGNNN GKLLGFEKKK ---------- ---------- ---------- ---------- ---------- ---------- AKKLLHHHKK VIIEEEPKKD DICCEFTHCL SGEEEVIISS LGDDDVGNNN GKVLPLESSS TSSLLHHHKK VVVEEESEED DIIIGFTHCL SGDDDIIISS LGDDDKGNNN AALLDFNKKK ARRIIHHHKK TVVEEEPYYE EVCCGNTHCL CGEEEIIISS IGDDDPGNNN GKLLGFEKKK ARRIIHHHKK TVVEEEPYYE EVCCGNTHCL CGEEEIIISS LGDDDPGNNN GKLLGFEKKK SSSLLHHHKK VVVDDDPAAD DITTGYTHCL SGEEELIISS LGDDDKGNNN AELLDFNKKK ASSLLHHHKK VVVEEEPEED DITTGYTHCL SGEEEIIISS IGDDDKGNNN AELLDFNKKK ASSLLYYYKK YVVDDDPKKE EITTGYTHCL SGEEEIVVSS LGDDDEGNNN AKLLDFNKKK ASSLLYYYKK YVVDDDPKKE EITTGFTHCR -GEEEIVVSS LGDDDEGNNN AKLLDFNKKK AAALLHHHKK VVVEEEAEED DITTGFTHCL SGEEEIIISS LGDDDKGNNN AALLDFNKKK KYYLLEEEHH TIIEEEPSSK KLNN-FTHCL DGNNNIIISS LGEEEAGTTT PSLLGFEKKK EYYLLQQQHH TIIEEEPSSK KLNN-FTHCL DGNNNIIISS LGEEEAGSSS PSLLGFEKKK ---------- ---------- ---------- ---------- ---------- ---------- AKKLLAAAKK VIIEEEG--D DVAADATHCL NGNNNIIISS MGDDDAGNNN AKVEDFEVVV KEEIIVVVKK TIIDDDG--D DVHHNATHCL NGNNNIIISS MGDDDAGYYY AKILDFNIII DQQFFYYYPP ---------D DLLLVITDYQ NTAAALQQDD VNEEESSVVV PVQTKNGSSS NKKLLHHHKK TIIDDDT--F FVGGGGTFAL GSMMMMTTGG SNDDDDHGGG GREYDEYAAA RVVLLSSSKK TIITTTD--F FVGGGGTYAL GRMMMLTTGG SNNNNKHGGG GREYNEYAAA GIIIRRGDDD QY-------- -----AADDW NN-PPNEVLV VSEPPN---- DDDGG-LLLL GVVVRRGPPP QY-------- -----AADDW NN-PPSGVMI ITEPPR---- EEEGG-FFFF GIIIRRGPPP QD-------- -----HHDDW NN-PPRDYMV VSEPPP---- NNNGG-IIII GIIIRRGPPP QT-------- -----HHDDW NN-PPRDYMV VTEPPP---- NNNGG-IIII GMMMRRGEEE QT-------- -----HHDDW NN-PPRDYMV VSEPPP---- NNNGG-IIII GVVVRRGPPP QY-------- -----AADDW HH-GGYDTLV VTEPPD---- DDDGG-LLLL GIIIRRGDDD QY-------- -----HHDDW HH-GGYDTLL LTEPPR---- SSSGG-VVVV GVVVRRGPPP QQ-------- -----AADDW HH-GGYDTMV VTEPPN---- GGGGG-LLLL GKKKGGGAAA SP-------- -----GGDDW QQ-RRHNVMV VSEPPN---- DDDGGFNNNN GKKKGGGEEE AP-------- -----GGDDW QQ-RRHNIMV VSEPPN---- DDDGGFNNNN GQQQGGGAAA AP-------- -----GGDDW QQ-RRHNVMI ISEPPN---- DDDGGFNNNN GQQQGGGAAA AP-------- -----GGDDW QQ-RRHNVMI ISEPPN---- DDDGGFNNNN GRRRGGGAAA AP-------- -----GGDDW QQ-RRHNVMI ISEPPN---- DDDGGFNNNN GRRRGGGAAA AP-------- -----GGDDW QQ-RRHNVMI ISEPPN---- DDDGGFNNNN GRRRGGGAAA AP-------- -----GGDDW QQ-RRHNVMI ISEPPN---- DDDGGFNNNN GRRRGGGAAA AP-------- -----GGDDW QQ-RRHNVMI ISEPPN---- DDDGGFNNNN GRRRGGGSSS AP-------- -----GGDDW QQ-RRHNVMI ISEPPN---- NNNGGFNNNN ---------- ---------- ---------- ---------- ---------- ---------- G--------- ---------- ---------- ---------- --ISSN---- TTTGGSRRRR GNNNLLFPPP IS-------- -----EETTL EEYAAWGLFW WSISSL---- TTTGGAEEEE GAAAGGEAAA AP-------- -----GGDDW QQ-RRHNVMI ISEPPK---- LLLGGFKKKK GVVVGGESSS AQ-------- -----GGDDW QQ-RRHNVMI ISEPPK---- LLLGGFKKKK GKKKGGHSSS PL-------- -----GGDDW QQ-RRHNTMI ISSPPT---- KKKGGFDDDD GKKKGGHSSS PL-------- -----GGDDW QQ-RRHNTMI ISSPPK---- QQQGGFNNNN NKKKGGHSSS PL-------- -----GGDDW QQ-RRHKTMI ISSPPK---- KKKGGFDDDD NKKKDDISSS PL-------- -----GGHHW QQ-RRHKTMI ISSPPK---- KKKGGFNNNN GKKKGGHSSS PL-------- -----GGDDW QQ-RRHKTMI ISSPPA---- TTTGGFDDDD GAAAEEKTTT VP-------- -----NNDDW QQ-RRRNVMI ISEPPN---- KKKGGFNNNN GAAAGGKVVV VP-------- -----NNDDW QQ-RRRNIMI ISEPPN---- KKKGGFNNNN ---------- ---------- ---------- ---------- -SLPPV---- RRRDDEEEEE GRRRDDRKKK AL-------- -----GGDDW QQ-HHFNVMV VAEPPK---- RRRGGYHHHH GKKKDDKKKK AL-------- -----GGDDW QQ-YYFDVMV VSEPPN---- RRRGGWKKKK AAAAQQFEEE EI-------- -----QQSSH NN---REKSE ESRPPI---- EEESSSEEEE TPPPAADDDD MQGVGGDAAA VVVAGGGDDR LL-RRKNVML LTSWWSNNNY FFFGGQMMMM TPPPDDGDDD LRGTGG-KKK YYYAGDDDDR LL-RRKNLLV VTSWWNNNNY FFFGGKMMMM LEEELL---- RYRRRIHFWD DRKKRRRIIH SSTTNMALL- -----LLRRL HHPPKKGFFI LEEELLGGGG AYKKKLHVWD DAKKRHHLLY AADDHMVLL- -----VVRRL HHPPKKGFFV PEEELLNNNN KYRRRLHFWD DRAARNNVVQ TTDDHMALL- -----VVRRA HHPPRRGFFV PEEELLNNNN KYRRRLHFWD DRAARNNVVQ TTDDHMALL- -----VVRRA HHPPRRGFFV PEEELLNNNN KYKKKIHFWK KRDDRNNVVQ TTDDHMALL- -----IIRRA HHPPKKGFFC PDDDLLAAAA RYRRRLHFWD DTRRRHHLLQ EEDDHLVFF- -----LLRRA HHPPKKGFFV GDDDLLGGGG KYRRRLHVWD DYRRRHHLLQ TTDDYMALL- -----LLRRA HHPPKKGFFM PQQQLLKKKK GYRRRLHIWD DRRRRHHLLQ AADDHMVLL- -----LLRRA HHPPRRGFFV AHHHEEGGGG LYRRRIFVWD DQRRHIIIIQ TTQQDLIPP- -----IIRRL HHPPAAGFFV AHHHEEGGGG LYHHHIHVWD DQRRHIIIIQ TTQQDLIPP- -----IIRRL HHPPAAGFFV ADDDEEGGGG LYHHHLHVWD DQRRHIIIIQ TTTTDLIPP- -----IIRRL HHPPAAGFFV ADDDKKGGGG LYHHHLYVWD DQRRRIIVVQ TTPPDLIPP- -----IIRRL HHPPAAGFFV ADDDEEGGGG LYHHHLYVWD DQHHHIIVVQ TTSSDLIPP- -----IIRRL HHPPAAGFFV ADDDEEGGGG LYHHHLYVWD DQRRHIIVVQ TTSSDLIPP- -----IIRRL HHPPAAGFFV ADDDEEGGGG LYHHHLYVWD DQRRHIIVVQ TTSSDLIPP- -----IIRRL HHPPAAGFFV ADDDEEGGGG LYHHHLYVWD DQRRHIIVVQ TTSSDLIPP- -----IIRRL HHPPAAGFFV ADDDEEGGGG LYHHHLHVWD DQRRHIIVVQ TTLLDHIPP- -----IIRRL HHPPAAGFFV ---------- ---------- ---------- ---------- ---------- ---------- YPPPSSSSSS RVIIIT---- ---------- ---------- ---------- ---------- MCCCTTSSSS GVIIISCLDN NIMMRIIDDE SSPPDAGAAN NNNPILLRRI HHKKIIDYYD EEEEQQGGGG MYSSSLNVWD DTEEHRRIIQ TTDDDLIPP- -----IIRRL HHPPAAGLLV EDDDQQGGGG HYSSSLNVWD DTEEHLLVVQ TTDDDLIPP- -----IIRRL HHPPAAGLLV QHHHAAGGGG LYHHHLTCIQ QARRGLLRRQ TTDDTLLPP- -----IIRRL HHPPKKGFFV QHHHAAGGGG LYHHHLHVYS SPGGGIIKKQ TTDDKLLPP- -----IIRRL HHPPKKGFFV QHHHAAGGGG LYHHHLHVYS SPGGGMMKKQ LLDDTLLPP- -----IIRRL HHPPKKGYYV QHHHAAGGGG LYHHHLHVYS SPGGGIIKKQ LLDDTLLPP- -----IIRRL HHPPKKGFFV QHHHQQGGGG LYHHHLHVYD DPGGGLLKKQ TTDDTLLPP- -----VVRRL HHPPKKGYYV AHHHGGGGGG LYSSSVHIFE EDSSKYYLLQ TTDDLALPP- -----VVRRL HHPPSSAFFV AHHHPPGGGG LYSSSVHIFE EDTTKHHLLQ TTDDRALPP- -----VVRRL HHPPSSAFFV KCCCPPPPPP LVCCCKRVY- ---------- ---------- ---------- ---------- TDDDDDTTTT QYRRRLNFYR RQEERLLFFQ TTDDDLTPP- -----IIRRL HHPPEEGYYV VDDDEESSSS QYRRRLNFYK KSTTQLLYYQ TTDDDITPP- -----IIRRL HHPPKKGFFV FLLLKKPPPP LKHHHVAEVL L--------- ---------- ---------- ---------- QDDDEEKKKK RFTTTIVQWD DHTTRPPKKK VVNNP----- -----IIRRP WWSSAAAFFS ADDDEEKKKK HFTTTVVTWD DHTTKPPKKK VVDDP----- -----IIRRA WWEEHHCFFT NVVSSSSLKK DDSSIWLWFF Y-EKKNAAEE KVIIIIEEIA PLEG-NLLLP PEPVVPVVVT NVLNNNNTKK DDSSIWLWFF Y-EKKQAAEE RVIIIIDDIA PFEG-PLLLP PPDVVPVVVT GVVDDDDTTT NNESIWTWWW R-EKKHVVKK KTAAAATTIA PATADELLLP PPGVVPVVVT GVVDDDDTTT NNESIWTWWW R-EKKHAAEE KTAAAATTIP PAPKEKLLLP PPGVVPVVVT GVVDDDDTTT NNQAIFTWWW QKDTTEAAKK KTIIIITTIP PADADDLLLP PDGCCPVVVT NVISSSSLKK DDSSIWTWYY R-DKKAVVRR KVIIIIEEIA AADPDQLLLP PPGVVPVVVT NVVSSSSLKK DDSSIWLWYY R-DSSHLLKK KVIIIIDDIA PASEDQLLLP PPPVVPVVVT GVVSSSSLEE DDSSVWLWHH R-QSSGIIRR KVIIIIEEIA PAEPDQLLLP PPDVVPVVVT GALSSSSSNN IIRYKNEEGG ---------- --TTTTWWSE VIQVPSKKKK KVMMMGIIIT GALSSSSSNN IIRYKNEGGG ---------- --TTTTWWSE VIQVPSKKKK KVMMMGIIIT GALSSSSSTT IIRYKNQGGG ---------- --TTTTWWSE VIQVPPKKKK KVMMMGIIIT GALSSSSSTT IIRFKNEDGG ---------- --TTTTWWSQ VIQVPPKKKK KVMMMGIIIT GALSSSSSTT IIRYKNEGGG ---------- --TTTTWWSE VIQVPPKKKK KVLMMGIIIT GALSSSSSTT IIRYKNEGGG ---------- --TTTTWWSE VIQVPPKKKK KVLMMGIIIT GALSSSSSTT IIRYKNEGGG ---------- --TTTTWWSE VIQVPPKKKK KVLMMGIIIT GALSSSSSTT IIRYKNEGGG ---------- --TTTTWWSE VIQVPPKKKK KVLMMGIIIT GALSSSSSTT IIRYKNEGGG ---------- --TTTTWWSE VIEVPPKKKK KVMMMGIIIT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VEVSSSSFSS GGGSDPDAYY ---------- --AAAAVVVK KLDLYYAAAV VVGLLNFFFP GALSSSSSTT VVRYKEKDGG ---------- --KKKKWWAE VIKVPSKKKK KVAMMGIIIT GALSSSSSSS IIRYKEKDGG ---------- --KKKKWWAE VIQVPSKKKK KVPMMGIIIT GALSSSSSNN MMRFKTQDGG ---------- --SSSSWWSE AIPVKPLLLK KVIMMGIIIT GALTTTTSNN MMRFKTQDGG ---------- --SSSSWWNE VISVEPLLLK KVFMMGIIIT GALSSSSSNN MMRFKNSDDD ---------- --TTTTWWSE VISVKPLLLK KVIMMGIIIT GALSSSSSNN MMRFKNSDEE ---------- --TTTTWWSE VISVKPLLLK KVIMMGIIIT GALTTTTSNN MMRFKTADGG ---------- --SSSSWWSE AISIKPLLLK KVIMMGIIIT GALGGGGSGG IIRHPVEENN S--------- T-TTTTHHAT VAFIPSKKKK KVAMMAIIIT GALGGGGSAA IIRHPDEKNN P--------- K-VVVVQQTS VATIPSKKKK KVAMMAIIIT ---------- ---------- ---------- ---------- ---------- ---------- GAFXXXXXXX XXXX------ ---------- ---------- ---------Q QGEMMGMMMT GALNNNNAKK VVHKKKSDSS D--------- EFEEEEAAKV DIPGKLVVVD DTVMMGIIIS ---------- ---------- ---------- ---------- ---------- ---------- TALTTTTSQQ LLLYEDDAGG ---------- ---------- --EWQAKKKA AVGDDPPPPV SALTTTTSQQ LLLYEDGEGG ---------- ---------- --EWQAKKKA AVGKKPPPPV TISSDKKLYL SSWGIIEEEQ QQQDDDSNPP KPPPLLLLTK KKVKLGGIIH RRRDDP---- TISSDRRLYV SSWGLLEEEQ QQQDDDTNPP QPPPLLLLAR RRVKIGGLLH RRRPPP---- TISSDRRLYV SSWGTTEEEQ QQQDDDSDPP NPPPLLLLAS SSVRIGGIIR RRRPPP---- TISSDRRLYV SSWGTTEEEQ QQQDDDSDPP KPPPLLLLAS SSVHIGGIIR RRRPPP---- TISSDKKLYV AAWGLLEEEQ QQQDDDSDPP NPPPLLLLTK KKVEIGGIIK KKKPPP---- TISSDRRLYV SSWGTTDDDQ QQQDDDSDPP EPPPLLLLTK KKVRIGGIIS RRRTTPG--- TISSDRRLYV SSWGTTEEEQ QQQDDDSDPP NPPPLLLLTK KKVQIGGIIR RRRGGP---- TISSDRRLYV SSWGTTEEEQ QQQDDDSDPP NPPPHHHHTS SSVRLGGIIR KKKAAP---- TISSDRRLYF SSWLHHDDDQ QQQDDDSNPP KPPPLLLLTQ QQIFLGGSSV RRRGGVQVLL TISSDRRLYF SSWLHHDDDQ QQQDDDSNPP KPPPLLLLTQ QQIFLGGSSV KKKGGVQVLL TISSDRRLYF SSWLHHDDDQ QQQDDDSDPP RPPPLLLLTQ QQLFLGGSSV KKKGGVQVLL TISSDHHLYF SSWLHHDDDQ QQQDDDSDPP RPPPLLLLTQ QQLFLGGSSV KKKGGVQVLL TISSDRRLYF SSWLHHDDDQ QQQDDDSDPP RPPPLLLLTQ QQLFLGGSSV KKKGGVQVLL TISSDRRLYF SSWLHHDDDQ QQQDDDSDPP RPPPLLLL-- ---------- ---------- T--------- ---------- ---------- ---------- ---------- ---------- TISSDRRLYF SSWLHHDDDQ QQQDDDSDPP RPPPLLLLTQ QQLFLGGSSV KKKGGVQVLL TISSDRRLYF NNWLHHDDDQ QQQDDDSDPP RPPPLLLLVQ QQIFLGGSSV KKKGGVQVLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PAFFDLLIIF LL-------- ---------- ---------- ---------- ---------- TISSDRRLYF SSWLHHDDDQ QQQDDDTDPP NPPPLLLLVQ QQIFLGGSSL RRRGGVTVLL TISSDRRLYF SSWLHHDDDQ QQQDDDTDTT NPPPLLLLVQ QQIFLGGSSQ RRRGGVTVLL TFSSDRRLYF VVWLHHDDDQ QQQNNNEDLL NPPPLLLLTQ QQLWVGGLLQ KKKSSVAAII TFSSDRRLYF VVWLHHDDDQ QQQNNNEDVV NPPPLLLLTQ QQVWAGGLLQ KKKSSVVAVV TFSSDRRLYF VVWLHHDDDQ QQQNNNEDPP NPPPLLLLTQ QQIWVGGLLQ KKKSSVKAVV TFSSDRRIYF VVWLHHDDDQ QQQNNNEDPP NPPPLLLLTQ QQIWVGGLLQ KKKSSVKAVV TFSSDRRLYL VVWLHHDDDQ QQQNNNEDPP KPPPLLLLAQ QQVWAGGLLQ KKKSSVVYVV TISSDRRLYV SSWLHHDDDQ QQQDDDSDPP KVVVLLLLNQ QQVYIGGSSH TTTSSVKVLL TISSDRRLYV SSWLHHDDDQ QQQDDDSDPP NPPPLLLLNQ QQVFIGGSSH SSSTTVKVLL ---------- ---------- ---------- ---------- ---------- ---------- TISSDRRLYF SSWRHHDDDQ QQQDDDSDRR NPPPLLLLTQ QQVFLGGAAQ RRRAARRVLL SISSDRRLYV NNWRHHDDDQ QQQDDDTDPP NPPPLLLLTQ QQLFLGGAAC SSSLLNVIVV ---------- ---------- ---------- ---------- ---------- ---------- VIAADQQLWI NNFMDDKKKL LLLDDDSDPP KPPPQQQQIE EEKVIDDQQN ---------- VISSDSSLWV NNFMDDKKKL LLLDDDSDPP HPPPQQQQVE EEKTIGGQQN ---------- ---------- ---------- --AKLLLTGA AAMIIISRGV YYVTTNNYYS TWDFFFYYPE ---------- ---------- --SEAAATGA AAMVVVSRGV YYITTNNYYS SWNFFFYYP- ---------- ---------- --NTFFFAGG GGMIIISRGV YYWTTNNYYS TWDFFFYYPD ---------- ---------- --NAFFFAAG GGMIIISRGV YYWTTNNYYS TWDFFFYYPD ---------- ---------- --NTFFFGYG GGMIIISRGV YYWTTNNYYS TWDFFFYYPG ---------- ---------- AAKALLLNGG GGMIIISRGV YYFTTNNYYG AVDFFFYYPE ---------- ---------- AATELLLNGG GGMIIISRGV YYFTTNNYYR AWDFFFYYPD ---------- ---------- --APLLLNGG GGMVVVSRGV YYFSSNNYYA SWDFFFYYPV --DDDQEEEE TCCQPEPPLV VVKRIIIPGG GGMLLLSLGL YYATTTTYYS DWDFFFYY-P --DDDQEEEE TCCQPEPPLV VVKRVVVPGG GGMLLLSLGL YYVTTTTYYS AWDFFFYY-P --DDDQEEEE KSSQPEPPLV VVKKVVVPGG GGMLLLSLGL YYVTTTTYYS AWDFFFYY-P --DDDQEEEE DSSQPEPPLV VVKQVVVAGG GGMLLLSLGL YYVTTTTYYS AWDFFFYY-P --DDDQEEEE KSSQPEPPLV VVKRVVVAGG GGMLLLSLGL YYITTTTYYS AWDFFFYY-P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --DDDEEEEE KSSQPEPPLV VVKRVVVAGG GGMLLLSLGL YYITTTTYYS AWDFFFYY-P --DDDQEEEE KSSQPEPPLV VVKRVVVPGG GGMLLLSLGI YYVTTTTYYS DWDFFFYY-P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --DDDKDDDD ECCQPDPPVI VVKKVVVPGG GGMLLLSLGL YYVTTNNYYS KWDFFFYY-P --DDDKEEEE ECCQPDPPVT VVKIIIIPGG GGMLLLSLGI YYVTTSSYYS IWDFFFYY-P --EEEDGGGG TWWQSDVVPE IIQKLLLRGG GGMLLLTLGL YYVTTNNFFS AWDFFFYY-P --DDDDGGGG TWWQSDVVPE IIQKLLLRGG GGMLLLSLGL YYVTTNNFFS AWDFFFYY-P --EEEDGGGG SFFQFDVVPQ IIKSLLLRGG GGMLLLSLGL YYATTNNFFS AWDFFFYY-P --EEEDGGGG TFFQFEVVPQ IIKSLLLRGG GGMLLLSLGL YYATTNNFFS AWVFFFYY-P --EEEDDDDD EEEQYSVVPQ VVKRLLLRGG GGMLLLSLGI YYVTTNNFFS RWDFFFYYGQ --GGGEKKKK ---PIEAALY VVKKIIIEGG GGMLLLSLGL YYVTTTTYYK KWDFFFYY-P --EEEDHHHH ---EIPAALY VVKQIIIEGG GGMLLLSLGL YYVSSTTYYK KWDFFFYY-P ---------- ---------- --------GG GGKLLLSVGL YYVTTNNYYS TWDFFFYY-P --DDDPEEEE KEEAPEPPVF LLKRLLLLGG GGMLLLSLGL YYVSSSSFFS PWDFFFYY-P EEDDDKEEEE KEERPPAARY VVKRLLLEGG GGMLLLSLGL YYVSSSSYYS PWDFFFYY-P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MQQQSWGV YYFSSSSLLA NWD------- ---------- ---------- ---------- --MSSSSWGL YYYTTSSLLA NWD------- GLKKWKKLAA NNN-PPPGGG GGLIIDDKFF VFFFFGGEE- ---ASHHVVV VSSDSSSY-- GLRRWKKVVV NNN-PPPGGG GGLLLEEKFF VFFFFGGRR- ---AAHHVVV VWWDSSTY-- GVPPALLAAA GGG-PPPGGG GGLLLAADWW VFFFFPPDDG G--YAHHIII IEEDSSTYSS GVPPVMMAVV GGG-GGGGGG GGLLLDDKFF VFFFFPPDDG G--YAHHIII IEEDSSTYSS DRGGAMMAVV GGG-EEEGGG GGLLLDDKWW VFFFFPPAAG G--YSHHIII IEEDSSTYSS GIDDWKKLAA GGG-PPPGGG GGIFFDDPFF LWWWWPPKKG G--HPHHVVV VQQDSSSY-- GIKKWKKVVV NNN-PPPGGG GGMFFDDPFF VFFFFGGEE- ---QVHHIII IQQDSSSF-- GIRRWKKAAA DDD-PPPGGG GGLLLDDPFF TVVVVGGDDG G--LPHHIII IEEDSSSYSS DLIIEVVMQQ VVVTVVVGGG GGLLLNNPLL VFFFFGGKKE EPGAAHHLLL LPPDSSS--- NLIIEVVMQQ IIITAAAGGG GGLLLNNPLL VFFFFGGKKE EPGAAHHLLL LPPDSSS--- DLIIEVVMQQ IIITVVVGGG GGLLLNNPLL VFFFFGGKKE EPGAAHHLLL LPPDSSS--- DLIIEVVMQQ IIITVVVGGG GGLLLNNPLL VFFFFGGKKE EPGAAHHLLL LPPDSSS--- DLIIEVVMQQ VVVTVVVGGG GGLLLNNPLL VFFFFGGKKE EPGAAHHLLL LPPDSSS--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DLIIEVVMQQ VVVTVVVGGG GGLLLNNPLL VFFFFGGKKE EPGAAHHLLL LPPDSSS--- DLIIEVVMQQ IIITVVVGGG GGLLLNNPLL VFFFFGGKKE EPGAAHHIII IPPDTTS--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DMIIEVVMQQ IIITEEEGGG GGLLLNNPLL VFFFFGGKKE EPGVAHHLLL LPPDSSS--- DLLLEVVMQQ IIITKKKGGG GGLLLNNPLL VFFFFGGKKE EPGVAHHIII IPPDTTS--- GLVVKHHIQQ IIITEEEGGG GGLIINNPFF VFFFFGGAAE EPGAAHHMMM MPPDTTS--- KLVVQHHIQQ IIITEEEGGG GGLIINNPFF VFFFFGGAAE EPGSAHHMMM MPPDTTS--- ELMMKHHIQQ IIITEEEGGG GGLIINNPFF VFFFFGGDDE EPGAAHHMMM MPPDTTS--- EIMMKHHIQQ IIITEEEGGG GGLIINNPFF VFFFFGGDDE EPGSAHHMMM MPPDTTS--- DLVVKHHMQQ IIITEEEGGG GGLIINNPFF VFFFFGGAAE EPGSAHHMMM MPPDTTS--- EHVVSTTMQQ VVVPEEEGGG GKMIINNRLL IFFFFGGKKI IEGYAHHMMM MPPDTTS--- ENVVSTTMQQ IIIPIIIGGG GHMIINNKLL IFFFFGGKKV VPGYAHHMMM MPPDTTS--- NVVVEVVMQQ IIITEEEGGG GGLVVNNKLL VFFFFGGKKE EPGCAHHIII IPPDTTS--- EMVVATTIQQ LLLVEEEGGG GGMLLNNELL VFFFFGGGGE EPGGPHHMMM M--------- KMVVQHHILL IIITVVVGGG GGILLNNELL VFFFFAANNE EPGSPHHMMM MPPDTTSADD ---------- ---------- ---------- ---------- ---------- ---------- ----KDDDQQ YYYYNNNDDD DGKLLVVEAA VFFFFYYEEL LGG-AHHMMM MGGAYYS--- ----KDDDQQ FFFYYYYDDD DGKLLKKEAA IFFFFYYAAE EKG-PHHMMM MGGAYYADNN ------- ------- V------ V------ V------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- A------ ------- ------- RQAAVVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSSAAAKA AKKQQPPSEE AAAPPPPRAA GLTADDDAMQ SSSLRRRLLL LPPGGGSPVR gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RIQATTTTSQ QASSPSSEES SKKTTTTTRR SSPPLLVVVI SSSVVVAKQV PPPSSSSSQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --ASPPPPLN NTPTPPPNNP PAASSSSSPP PPPPVVPPPT RRRRRRPYRT NNNVVVVVPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMAII VPPFDTYSSP PPPPMMKAPP ---------- ---------- ---------- --------MM AKKLDTYTTP PPPPDMRAPP ---------- ---------- ---------- ---------- MSSMDTHSSP PPPPLMQAPP ---------- ---------- ---------- ---------- MTTMDTHSSP PPPPLMEAPP ---------- ---------- ---------- ---------- MTTLDTYSSA AAAALMEGPP ---------- ---------- ---------- --------MM ATTWDSYSSP PPPPLAKAPP ---------- ---------- ---------- --------MM VTTWDTYSSP PPPPMVKAPP ---------- ---------- ---------- --------MM ASSWDTYSSP PPPPMMQAPP ---------- ---------- ---------- ---MATTKCC TKK-GGPPPL LLLLAK-GPP ---------- ---------- ---------- ---------- ---------- -----M-GPP WAHWLPPPGK HGAAAVVIIA PPAGGGLLLP P-AHSTTQCC GKK-GGPPPL LLLLAK-GPP ---------- ---------- ---------- ---------- ---------- -----K-GPP ---------- ---------- ---------- ---MATTKCC GNN-GGSPPL LLLLAK-GPP -----AAERA EGAAATTQQS VVAPPPMMRP PASTATTKCC GNN-GGSPPL LLLLAK-GPP ---------- ---------- ---------- ---MATTKCC GNN-GGSPPL LLLLAK-G-- ---------- ---------- ---------- ---MATTKCC GNN-GGSPPL LLLLAK-GPP --MGLGGKEE PGHHHAAPPW FFLGGGQQLW WEDTATTKCC GDD-GGPPPQ QQQQAK-GPP LLKNSQQGCL GFDDDTTTTE LLHYYYCCTL LFTSPTTKCC GNN-GGSPPL LLLLAK-GPP ---------- ---------- ---------- ---MATTKCC GNN-GGSPPL LLLLAK-GPP CPPHARRHSL VLQQQIIEEG AAAVVVEETA AAANGKKTCC CHHTGGAPPL LLLLAEKGPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MAAKCC GSS-GGKPPL LLLLAK-GPP ---------- -------AAT VVLHHHGGVV VEKKS--VNN GCCCGGAPPI IIIISS-GPP ---------- -------GGT VVLHHHAAVV VEKVNNNQQQ GCCCGGAPPL LLLLAS-GPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------RR MLLQGGAPPL LLLLAS-GPP ---------- ---------- --------MA AAANGAAACC CGGGGGAPPL LLLLAEKGPP ---------- ---------- ---------M MPNCGLLKCC HGG-GGAPPA AAAAAK-GPP ---------- ---------- ---------M M--CPLLKCC HGG-GGAPPA AAAAAK-GPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMSEE SKKCGGAPPL LLLLARNGPP ---------- ---------- ---------- ---------- ---------- -----RSGPP ---------- ---------- ---------- ---------- ----MGI--- ----IISLDD ----MKKRRE FG-------- ---AAALLAA A-ALAMMGLL PFFRAECSSP PPPPMKITGG ----MKKRFI VSGGGSSHHF AALAAALLVS SLALALLAAA PAAGAECSSP PPPPMKITGG DDAAACCGTT IINAAADDFF IIAVVVDDDD VPSSSSSSSK KIIHHKVLLY YINDEHHHWW DDAAAAAGTT VVNPPPDDFF LLAVVVDDDD VPSSSSGGGK KVVYYKLLLY YIGDEHHHWW EEALLLLDFF ---PPPDDAA LLAVVIDDDD VPSSSSGGGK KIIHHTVMMN NTGDEHHHWW NNALLLLDFF ---PPPDDAA LLAVVIDDDD VPSSSSGGGQ QIIHHTVMMN NKGDEHHHWW KKALLMMDAA ---PPPDDGG LLAVVVDDDD VPSSSSGGGQ QIIHHQLMMN NKGDEHHHWW TTAAAMMERR ---PPPDDAA IIAVVVDDDD VPSSSSAAAS SIIGGQVMMH HAGDEHHHWW KKAVVRRMAA GG-PPPDDAA MMCVVVDDDD VSSSSSGGGQ QVVGGVTMMY YTGGEHHHWW RRGAALLGRR ---PPPDDAA LLGVVLDDDD LPSSSSAAAQ QIIGGRVMMN NAADEHHHWW EEVPPCCNTT TTEPPPDDYY LLATTVDDDD VPSSSSSSSQ QVVHHRLMMY YLKDEHHHWW EEVPPCCNTT IIEPPPDDYY LLATTVDDDD VPSSSSSSSQ QVVHHRLMMH HLKDEHHHWW EEVPPCCNTT IIEPPPDDYY LLATTVDDDD IPSSSSCCCQ QVVHHRLMMN NLRDEHHHWW EEIPPCCNTT IIEPPPDDYY LLATTVDDDD VPSSSSCCCQ QVVHHRLMMH HLKDEHHHWW EEVPPCCNTT TTEPPPDDYY LLATTVDDDD VPSSSSCCCQ QVVHHRLMMN NLKDEHHHWW EEVPPCCNTT TTEPPPDDYY LLATTVDDDD VPSSSSCCCQ QVVEE----- ---------- ---------- TTEPPPDDYY LLATTVDDDD VPSSSSCCCQ QVVHHRLMMN NLKDEHHHWW EEVPPCCNTT TTEPPPDDYY LLATTVDDDD VPSSSSCCCQ QVVHHRLMMN NLKDEHHHWW EEVPPCCNTT TTEPPPDDYY LLATTVDDDD VPSSSSSSSQ QVVHHRLMMY YLKDEHHHWW EEVPPCCNTT TTEPPPDDYY LLATTVDDDD VPSSSSCCCQ QVVHHRLMMN NLKDEHHHWW EEVPPCCNTT TTEPPPDDYY LLATTVDDDD VPSSSSCCCQ QVVHHRLMMN NLKDEHHHWW KKVTTCCGTT IINLLLDDYY LLATTVDDDD LPSSSSSSSQ QVVHHRLVVH HIGDKHHHWW ---------- ---------- ---------- ---------- -------MMN NTNDEHHHWW EEVPPCCSTT IINPPPDDYY LLATTVDDDD VPSSSSSSSQ QVVHHRLMMN NVNDEHHHWW SSITTAAGTT IIEPPPDDYY LLATTVDDDD VPSSSSSSSK KVVHHRLVVY YVGDEHHHWW TTITTAAGTT IIEPPPDDYY LLATTVDDDD LPSSSSSSSK KVVHHRLVVY YVGDEHHHWW ---------- ---------- ---------- ---------- -------MMF FVGDEHHHWW KKITTAAGTT IIDPPPDDYY LLATTVDDDD VPSSSSSSSS SVVHHRLMMF FVGDEHHHWW KKLTTCCGTT IINPPPDDYY LLGTTVDDDD VPSSSSSSSQ QVVHHRLVVH HVGDEHHHWW EELTTAA-NN AADPPPDDAA IIFTTVDDDD VPSSSSCCCQ QVVSSRVVVH HIGDEHHHWW EELTTAA-HH RRDPPPDDAA IIFTTVNNNN VPSSSSCCCQ QIISSRVVVN NIGDEHHHWW ---------- ---------- ---------- ---------- ---------- ---------- KKLVVCCNLL EEEGGGDDYY LLATTVDDDD VPSSSSCCCQ QVVHHRTTTS SKHNEHHHWW KKLVVTTNLL EEPGGGDDYY LLSTTVDDDD VPSSSSCCCQ QIIHHRTTTR RKGDEHHHWW FFYNNWWDII QQYIIITTDD RRKNNPRRRR MGVVVVGGGS SVVKKDGVVV VLEDKLDDPP EEVWWTTEGG GGDQQQDDKK LLVTTIDDDD LPSSSSGGGQ QVVNNSVVVG G-RNEHHHFF DDVWWTTEGG GGDQQQDDKK LLVTTVDDDD APSSSSGGGK KVVNNTLVVG G-RNEHHHFF CCCCSAACC- --KPPPNRRF FLVPGGLLRS SSRRIIDDKP NPEPPKKKKV VIEPPEVKKK CCCCSAACC- --KPPPFRRY YLVPAALLRS SSRRIVDDKP DKRPPAAAKI IVEPPVAVGG CCCCSSSSS- -GHAAAFRRF FLIPGGLLRS SSRRVIDDKP HPQAARRRKI IIEPPEILAA CCCCSAASS- -GHAAAFRRY YLIPGGLLRS SSRRIIDDKP DPKAAKKKKI IIEPPEVFKK CCCCSAASS- -GHAAAFRRY YLIPGGIIRS SSRRIVDDK- EPKAAKKKKI IIEPPEVFAA CCCCSCCCC- -PHPPPHRRY YLVPGGLLRS SSRRILDDKP DPKPPFFFKV VIEPPTLAEE CCCCSMMCC- -PHPPPHRRY YLVPDDIIRS SSHHILDDKP DPQPPKKKKV VIDPPELAEE CCCCSAACC- -PHPPPHRRY YLVPGGIIRS SSRRIVDDKP DPEPPRRRKV VIEPPELHRR CCCCSCC--- -GDSSSTRNK KLLPGGLLMS SSRRVVDDGS EPAPPKKKKV VIEAAEIQAA CCCCSCC--- -GDSSSTRDK KLLPSSIIIS SSRRVVDDGS EPAPPKKKKV VIEPPEIHAA CCCCSCC--- -GDSSSTRTK KLLPCCLLMS SSRRVVDDGS DPAPPKKKKV VIEAADIHAA CCCCSCC--- -GDIIITRTK KLLPAALLIS SSRRVVDDGT EPAPPKKKKV VIEPPDIHTT CCCCSCC--- -GDSSSTRTK KLLPSSLLIS SSRRVVDDGS EPAPPKKKKV VIEPPDIHAA ---------- ---------- ---------- ---------- ---------- ---PPDIHAA CCCCSCC--- -GDSSSTRTK KLLPSSLLIS SSRRVVDDGS EPAPPKKKKV VIEPPDIHAA CCCCSCC--- -GDSSSTRTK KLLPSSLLIS SSRRVVDDGS EPAPPKKKKV VIEPPDIHAA CCCCSCC--- -GDSSSTRNK KLLPSSFFIS SSRRVVDDGT EPAPPKKKKV VIEAADIHEE CCCCSCC--- -GDSSSTRTK KLLPSSLL-- ---------- ---------- ---------- CCCCSCC--- -GDSSSTRTK KLLPSSLLIS SSRRVVDDGS EPAPPKKKKV VIEPPDIHAA CCCCSCC--- -GDPPPSRRF FLLPSSLLLS SSRRVVDDAT DPTPPSSSKV VVESSDIAEE CCCCSCC--- -GDAAASRNK KLLPCCLLIS SSRRVVDDGT DPAPPRRRKT TVEPPEVFWW CCCCSCC--- -GDSSSSRNK KLLPCCLLIS SSRRVVDDGS DPAPPRRRKT TVEPPEVFWW CCCCSCC--- -GDPPPSRRF FLAPSSLLVS SSRRVIDDKT NPSPPSSSKV VVDPPDIIQQ CCCCSCC--- -GDPPPSRRF FLVPGGIIVS SSRRVIDDKT NPAPPSSSKV VVEPPDISTT CCCCSCC--- -GDAAASRRY YLLPSSLLIS SSRRAIDDKE NPAPPSSSKY YVDPPEIAEE CCCCSCC--- -GDAAASRRY YLLPSSLLIS SSRRAIDDKE NPAPPSSSKY YVDPPEIADD CCCCSCC--- -GDPPPSRRF FLLPSSLLLS SSRRVVDDLK DPAPPAAAKV VVEAADIAEE CCCCSCC--- -DKPPPTRSH HLVPCCLLNS SSRRIINNEN E-KIIYYYHT TIEPPKLHSS CCCCSCC--- -DKPPPTRSH HLVPCCLLNS SSRRVINNEN E-EIIYYYHT TIEPPKLHAA ---------- ---------- -MPRKKLLSS SSVVKVFFGG ---------- ---------- CCCCSCCFFV VGKEEEVRDR RLLPCCLLNS SSRRVIDDGT DPAPPKKKKV VIEGGDVLKK CCCCSCCYYV VSKTTTVRDR RLLPSSLLNS SSFFILDDVT DPKPPEEEKT TIDGGDVLKK RRRRIKK--- -GKRRRVGPQ QMQLSSLLDG GGRRVTTTLY SADKKQQQP- -----DLIKK ---------- -------RRF FFTGGGLLDT TTRRIFDDHS DPNPPKKKKT TIDTTFVKDD ---------- -------RRY YLAGGGLLDT TTKKVFDDHS DPRPPVVVKT TITDDFVEKK VRRLLHHHTT GDDAGGG-G- -PGGIIMYFE PPPLGWWIID DDRRGDD--- -------AYF RKKYYHHHTT GDDAGGG-GR RPGGIILDFE PPPIGWWVVY YYRRGPP--- -------AYF KRRPPHHHTT GEEGGGGKGT TAPGIIIEFD VVVLGWWIID DDRRGPP--- -------HYF KRRPPHHHTT GDDGGGGKGT TPPGVVIEFE VVVLGWWIID DDRRGPP--- -------HYF KRRPPHHHTT GEEGGGGEGT TPPGIIIEFE IIILGYYMMD DDRRGEE--- -------HYF RRRPPHHHTT GGGGGGG-G- -PGGIIMQFE PPPLGWWVVE EERRGPP--- -------AYG RRRPPHHHTT GDDGGGG-G- -PGGIIIDLE VVVLGWWIID DDRRGDD--- -------HYF RRRPPHHHTT GDDGGGG-G- -PGGVVVEFD PPPLGWWVVE EERRGPP--- -------AYF KNNTTHHHTT LSSGLLL-QG GKGSFFLEFE VVVKGWWKKP PPGGGAA--- -------GYF KNNLLHHHTT LSSGLLL-QG GKGGFFLEFE VVVKGWWKKP PPGGGEE--- -------GYF KYYVVHHHTT LSSGLLL-KG GKGGFFLEFE VVVKGWWQQP PPGGGAA--- -------GYF KFFFFHHHTT LSSGLLL-EG GKGGFFLKFE VVVKGWWQQP PPGGGAA--- -------GYF KFFLLHHHTT LSSGLLL-KG GKGGFFLEFE VVVKGWWRRP PPGGGAA--- -------GYF KFFLLHHHTT LSSGLLL-KG GKGGFFLEFE VVVKGWWRRP PPGGGAA--- -------GYF KFFLLHHHTT LSSGLLL-KG GKGGFFLEFE VVVKGWWRRP PPGGGAA--- -------GYF KFFLLHHHTT LSSGLLL-KG GKGGFFLEFE VVVKGWWRRP PPGGGAA--- -------GYF KTTPPHHHTT LTTGLLL-KG GKGGFFLEFE VVVKGWWRRP PPGGGSS--- -------GYF ---------- ---------- ---------- ---------- ---------- ---------- KFFLLHHHTT LSSGLLL-KG GKDGSSV-LE CCCSG----- ---------- ---------- NFFPPHHHTT LSSGLLL-EG GAGNGGLSFN VVVKGGGNNR RRLLFPP--- -------ERH KNNLLHHHTT LCCGIII-YG GKGGFFLEFE VVVKGWWAAE EEGGEAA--- -------GYF KNNPPHHHTT LCCGLLL-CG GKGGFFLEFE VVVKGWWVVE EEGGESS--- -------GYF KYYPPHHHTT LSSGLLL-DG GEGNGGLSFN VVVKGWWKKP PPGGHSS--- -------GYF KYYPPHHHTT LSSGIII-DG GEGNGGLSFN VVVKGWWKKP PPGGHSS--- -------GYF KYYPPHHHTT LSSGLLL-EG GKGNGGLSFN IIIKNWWKKP PPGGHSS--- -------GYF KFFPPHHHTT R--GLLL-EG GKGNGGLSFN IIIKNWWKKP PPDDISS--- -------GYF KFFPPHHHTT LSSGLLL-EG GAGNGGLSFN VVVKGWWKKP PPGGHSS--- -------GYY LFFPPHHHTT LDDGLLL-NG GSGNFFLKFE PPPKGWWAAD DDEEKTT--- -------NYF LFFPPHHHTT LDDGLLL-DG GSGNFFLKFE PPPKGWWAAD DDGGKVV--- -------NYF ---------- ---------- ---------- ---------- ---------- ---------- GAAPPHHHTT LNNGMMM-EG GKG-DDVKFE LLLVGWWRRG GGDDRKK--- -------GYY SAAPPHHHTT LNNGMMM-EG GKG-DDISFN CCCIGWWKKG GGDDKKK--- -------GYF FIISSHHHTT QNNTVVV-LS SVLNGGQHNG LLLSAGGAAS SSQQFEE--- -------QLN SGGPPHHHTT LGGSSSS-DH HRTALLEDEY VVVATWWPPT TTAADDDAVA AAAAAAGGYI SGGPPHHHTT LGGRSSS-DH HRTALLEAEY VVVATWWPPT TTDDGDDAIK KKKKKAGDYV FWWNNLLWAA PPNN-TTIIE EDGGKLLLHH HLD--RYNNI FWDDDKKRKK RHHLGGGENR FWWNNLMWTT PPRR-CCFFE EEGGSLLLCC CLEGGAYNNL VWDDDKKRRR HYYLGGGQHR FWWNNLMWAA PPPP-QQFFE ENGGVPPPDD DLANNKYHHL FWDDDAARRR NQQLGGGAHQ FWWNNLMWAA PPPP-QQFFE ENGGVPPPDD DLSNNKYHHL FWDDDAARRR NQQLGGGAHQ FWWNNLMWGG PPPP-QQFFE ENGGVPPPDD DLSNNKYHHI FWKKKDDRKK NQQLGGGAHQ GWWHHLLWGG PPDD-MMVVE EDGGVPPPII ILGAARYRRL FWDDDRRRRR HQQFGGGDHQ FWWHHLLWGG PPRR-MMVVE ESGGLGGGEE ELAGGKYHHL VWDDDRRRRR HQQLGGGAYQ FWWHHLMWGG PPNN-MMIIE EGGGDPPPII ILNKKGYRRL IWDDDRRRRR HQQVGGGEHQ FYYQQPMWAA PPNN-VVFFK KDGGPAAAVV VE-GGLYSSI VWDDDRRHEE IQQMTTT-DG FYYQQPMWAA PPNN-VVFFK KDGGPAAAVV VE-GGLYSSI VWDDDRRHEE IQQMKKK-DG FYYQQPMWAA PPNN-VVFFR RDGGPAAAVV VE-GGLYSSL VWDDDRRHEE IQQLQQQ-DG FYYQQPMWAA PPNN-VVLLR RDGGPAAAVV VK-GGLYSSL VWDDDRRREE IQQLQQQ-DG FYYQQPMWAA PPNN-VVLLR RDGGPAAAVV VE-GGLYSSL VWDDDHHHEE IQQLKKK-DG FYYQQPMWAA PPNN-VVLLR RDGGPAAAVV VE-GGLYSSL VWDDDRRHEE IQQLKKK-DG FYYQQPMWAA PPNN-VVLLR RDGGPAAAVV VE-GGLYSSL VWDDDRRHEE IQQLKKK-DG FYYQQPMWAA PPNN-VVLLR RDGGPAAAVV VE-GGLYSSL VWDDDRRHEE IQQLKKK-DG FYYQQPMWAA PPNN-VVVVQ QNGGPAAAVV VE-GGLYKKL VWDDDRRHEE IQQMPPP-DG ---------- ---------- ---------- ---------- ---------- ---------- -------SAA SSNN-LLRRL LTGGDYYYAA AS-SSRVGGT ---------- ---------- HYYEENFQCC SSLL-FFYYT TTGGLMMMLL LT-SSGVVVS LDNNNMMRVV IEELQQQ-DQ FYYQQPMWGG PPKK-AAFFA ALGGMEEEVV VQ-GGMYHHL VWDDDEEHRR RQQLGGGEDG FYYQQPMWGG PPKK-AAFFA ALGGMEEEVV VQ-GGHYHHL VWDDDEEHRR LQQLGGGKDG FYYQQPMWGG PPTT-AAFFT TKGGLQQQVV VA-GGLYRRL CIQQQRRGEE LQQLGGGNTG FYYQQPMWGG PPKK-AAFFL LQGGLQQQVV VA-GGLYRRL VYSSSGGGEE IQQLGGGDKG FYYQQPMWGG PPKK-AAFFS SKGGLQQQVV VA-GGLYSSL VYSSSGGGEE MQQLGGGETG FYYQQPMWGG PPKK-AAFFS SKGGLQQQVV VA-GGLYSSL VYSSSGGGEE IQQLGGGPTG YYYQQPMWGG PPAA-AAFFR RTGGLQQQVV VQ-GGLYRRL VYDDDGGGEE LQQLGGGSTG FYYQQPMWGG PPNN-HHIIK KKGGPAAAVV VG-GGLYNNV IFEEESSKKK YQQLPPPQLG FYYQQPMWGG PPNN-HHIIK KKGGPAAAVV VP-GGLYNNV IFEEETTKKK HQQLPPPMRG -------RGG PPVV-TTVVC CRDDLKKKQQ QP-PPLVKKK VY-------- ---------- YYYQQPMWGG PPKK-LLFFR RRGGPTTTCC CDRTTQYCCL FYRRREEREE LQQLGGGDDG FYYQQPMWGG PPNN-KKWWR RRGGNVVVLL LEMSSQYCCL FYKKKTTQTT LQQLGGGSDG NNNNNGSPDD PPII-MMAAF FESSSFFFKK KKGPPLKQQV EVLLL----- ---------- IAALLIMFTT WWSSNMMMMD DFGGLQQQAA AEMKKRFNNI QWDDDTTRQQ PKKVPPPGP- VAALLPLFTT WWNNNMMMMD DFGGLAAAPP PEMKKHFNNV TWDDDTTKQQ PKKVPPPGP- MAL------- -EEERRPLLD PPKLMGFMMV SSSLLLLKDS IIWLWYY--E DDGAKKVIIE MVL------- -EEERRPLLD PPKLMGFVVL NNNTTTTKDS IIWLWYY--E DDGARRVIID MAL------- -EEERRPAAD PPREYGFVVV DDDTTTTTNG IIWTWRR--E GGGVKKTAAT MAL------- -EEERRPAAD PPREYGFVVV DDDTTTTTNA IIWTWRR--E GGGAKKTAAT MAL------- -EEERRPAAD PPKDYGFVVV DDDTTTTTNG IIFTWQQKKD DDGAKKTIIT LVF------- -EEERRPAAD PPKAYGFCCI SSSLLLLKDS IIWTWRR--D KKDVKKVIIE MAL------- -EEERRPAAD PPKAYGFCCV SSSLLLLKDA IIWLWRR--D NNGLKKVIID MVL------- -EEERRPAAD PPRTYGFVVV SSSLLLLEDA VVWLWRR--Q NNGIKKVIIE LIP------- LEEERRFLLD PPATQGFCCL SSSSSSSNIF KKNEE----- -------TTW LIP------- LEEERRFLLD PPATQGFCCL SSSSSSSNIF KKNEG----- -------TTW LIP------- LEEERRFLLN PPAAQGFCCL SSSSSSSTIF KKNQG----- -------TTW LIP------- LEEERRFLLN PPAAQGFCCL SSSSSSSTIF KKNED----- -------TTW LIP------- LEEERRFLLN PPAAQGFCCL SSSSSSSTIF KKNEG----- -------TTW LIP------- LEEERRFLLN PPAAQGFCCL SSSSSSSTIF KKNEG----- -------TTW LIP------- LEEERRFLLN PPAAQGFCCL SSSSSSSTIF KKNEG----- -------TTW LIP------- LEEERRFLLN PPAAQGFCCL SSSSSSSTIF KKNEG----- -------TTW HIP------- LEEERRFLLD PPASQGFCCL SSSSSSSTIF KKNEG----- -------TTW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AGANNNPPII LCCCRRSIIW KKINQDYVVV SSSFFFFSGG DDPDA----- -------AAV LIP------- LEEERRFLLD PPAAQGLCCL SSSSSSSTVF KKEKD----- -------KKW LIP------- LEEERRFLLN PPADQGLCCL SSSSSSSSIF KKEKD----- -------KKW LLP------- LEEERRFLLD PPKDTGFSSL SSSSSSSNMF KKTQD----- -------SSW LLP------- LEEERRFLLD PPKDTGFSSL TTTSSSSNMF KKTQD----- -------SSW LLP------- LEEERRFLLD PPKDTGYSSL SSSSSSSNMF KKNSD----- -------TTW LLP------- LEEERRFLLD PPKDTGFSSL SSSSSSSNMF KKNSD----- -------TTW LLP------- LEEERRFLLD PPKDTGYCCL TTTSSSSNMF KKTAD----- -------SSW ALP------- LEEERRFLLE PPSEHAFCCL GGGSSSSGII PPVEESS--- ----TT-TTH ALP------- LEEERRFLLE PPSEHAFCCL GGGSSSSAII PPDEKPP--- ----KK-VVQ ---------- ---------- ---------- ---------- ---------- ---------- LTP------- LEEERRFLLN PPENQGYCCF XXXXXXXXXX ---------- ---------- ITP------- LEEERRFLLN PPKAEGFCCL NNNAAAAKVF KKKSDDD--- ----EEFEEA ---------- ---------- ---------- ---------- ---------- ---------- ---------- LEEERRFPPG SSANYAFTTL TTTSSSSQLI EEDDA----- ---------- ---------- LEEERRCAAG EEHNYCFTTL TTTSSSSQLI EEDGE----- ---------- IIEEEGEIIL PAAAPLLVVT TDDIISLDDD DKKKFFFLLL WWEEEVRQYY INKKKLGVKG IIQEEGPVVL DMMMPLLVVT TDDIISLDDD DRRRFFFLLL WWEEELRQYY INQQQLGVKG IIETTAPLLL GAAAPLLVVT TDDILSLDDD DRRRFFFCCC WWEEEMRQYY VDNNNLGVRG IIEPPKPLLL GAAAPLLVVT TDDILSMDDD DRRRFFFCCC WWEEEMRQYY VDKKKLGVHG IIVDDADLLL GAAAPLLVVT TDDILSLDDD DKKKYYYCCC WWEEEMHQYY VDNNNLGVEG IIEDDPPVVL GAAAPLLVVT TDDILSMDDD DRRRFFFCCC WWDDDLLQYY VDEEELGVRG IIESSEPIIL PAAAPLLVVT TDDILSVDDD DRRRFFFCCC WWEEELHQYY VDNNNLGVQG IIEEEPPLLL DAAAPLLVVT TDDILSLDDD DRRRFFFCCC WWEEELRQYY VDNNNHGVRG SSKQQVVKKG MEEEPLLIIT TDDILSLDDD DRRRFFFNNN WWDDDIRQYY INKKKLGIFG SSKQQVVKKG MEEEPLLIIT TDDILSLDDD DRRRFFFNNN WWDDDIRQYY INKKKLGIFG SSKQQVVKKG MEEEPLLIIT TDDILSLDDD DRRRFFFNNN WWDDDLRQYY IDRRRLGLFG SSKQQVVKKG MEEEPLLIIT TDDILSLDDD DHHHFFFNNN WWDDDIRQYY VDRRRLGLFG SSKQQVVKKG LEEEPLLIIT TDDILSLDDD DRRRFFFNNN WWDDDLRQYY IDRRRLGLFG SSKQQVVKKG LEEEPLLIIT TDDILSLDDD DRRRFFFNNN WWDDDLRQYY IDRRRL---- SSKQQVVKKG LEEEPLLIIT T--------- ---------- ---------- ---------- SSKQQVVKKG LEEEPLLIIT TDDILSLDDD DRRRFFFNNN WWDDDLRQYY IDRRRLGLFG SSKEEVVKKG MEEEPLLIIT TDDILSLDDD DRRRFFFNNN WWDDDMRQYY IDRRRLGIFG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVRDDLVAAK GSSSSEEFFP PPPAIFFSDD DLLLLLLSSS ---------- ---------- AAKKKVVEEG AEEEPLLIIT TDDIISLDDD DRRRFFFNNN WWDDDIRQYY IDNNNLGIFG AAKQQVVEEG PEEEPLLIIT TDDIISLDDD DRRRFFFNNN WWDDDIRQYY IDNNNLGIFG SSLPPVVQQN IEEEPLLIIT TDDFISLDDD DRRRFFFNNN WWDDDIRQYY IDNNNLGLWG NNISSVVQQN FEEEPLLIIT TDDFISLDDD DRRRFFFNNN WWDDDIRQYY IDNNNLGVWG SSISSVVEEN IEEEPLLIIT TDDFISLDDD DRRRFFFNNN WWDDDIRQYY IDNNNLGIWG SSVSSVVEEN IEEEPLLIIT TDDFISLDDD DRRRFFFNNN WWDDDIRQYY IDNNNLGIWG SSVSSIVRRN IEEEPLLIIT TDDFISLDDD DRRRYYYNNN WWDDDIRQYY IDKKKLGVWG AALFFIVSSG AEEEPLLIIT TDDIISMDDD DRRRFFFCCC WWDDDIRQYY IDKKKLSVYG TTLTTIVEEN ADDDPLLIIT TDDIISMDDD DRRRFFFCCC WWDDDIRQYY IDNNNLSVFG ---------- ---------- ---------- ---------- ---------- ---------- ------GEEN EMMMGMMMMT TDDIISLDDD DRRRYYYNNN WWDDDVRQYY IDNNNLGVFG KKIPPGTGGS VDDDGMMIIS SDDIISLDDD DRRRFFFCCC WWDDDVRQYY IDNNNLGLFG ---------- ---------- ---------- ---------- ---------- ---------- ---EEWVAAD GAAAILLPPV VDDIIAADDD DQQQTTTSSS FFKKKTRLFF IDKKKQYKVD ---EEWVAAD GAAAVLLPPV VDDIISNDDD DSSSRRRTTT FFKKKTRLFF IDHHHQYKTG GFADP----- ---------- AKKLLTTGAP PPPQQMLLER RDRVYYYYYV TNSLLLLYDD GYEPP----- ---------- SEEAATTGAP PPPQQMIISR RDRVYYYYYI TNSLLLLYNN GAAPP----- ---------- NTTFFAAGGP PPPQQMVVER RDRVYYYYYW TNSLLLLYDD GATPP----- ---------- NAAFFAAAGP PPPQQMVVER RDRVYYYYYW TNSLLLLYDD GVTPP----- ---------- NTTFFGGYGP PPPQQMVVER RDRVYYYYYW TNSLLLLYDD GVATP----- ---------- KAALLNNGGP PPPQQMVVER RDRVYYYYYF TNSLLLLYDD GVAGP----- ---------- TEELLNNGGP PPPQQMVVER RDRVYYYYYF TNSLLLLYDD GVAAP----- ---------- APPLLNNGGP PPPQQMVVER RDRVYYYYYF SNSLLLLYDD GIGGVVLE-- -DQQETTCPP KRRIIPPGGP PPPQQMIIQL LDRLYYYYYA TTSLLLLYDD GIGGVVLE-- -DQQETTCPP KRRVVPPGGP PPPQQMIIQL LDRLYYYYYV TTSLLLLYDD GIGGVVLE-- -DQQEKKSPP KKKVVPPGGP PPPQQMIIQL LDRLYYYYYV TTSLLLLYDD GIDGVVLD-- -DQQEDDSPP KQQVVAAGGP PPPQQMIIQL LDRLYYYYYV TTSLLLLYDD GIGGVVLE-- -DQQEKKSPP KRRVVAAGGP PPPQQMIIQL LDRLYYYYYI TTSLLLLYDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GIGGVVLE-- -DEEEKKSPP KRRVVAAGGP PPPQQMIIQL LDRLYYYYYI TTSLLLLYDD GIGGVVLE-- -DQQEKKSPP KRRVVPPGGP PPPQQMIIQL LDRIYYYYYV TTSLLLLYDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GIGGVVLE-- -DKKDEECPP KKKVVPPGGP PPPQQMIIQL LDRLYYYYYV TNSLLLLYDD GIGGVVLE-- -DKKEEECPP KIIIIPPGGP PPPQQMIIQL LDRIYYYYYV TSSLLLLYDD GIGSVAIG-- -EDDGTTWSV QKKLLRRGGP PPPQQMIIQL LDRLYYYYYV TNSLLLLFDD GIGSVAVK-- -DDDGTTWSV QKKLLRRGGP PPPQQMIIQL LDRLYYYYYV TNSLLLLFDD GLGSVAVG-- -EDDGSSFFV KSSLLRRGGP PPPQQMIIQL LDRLYYYYYA TNSLLLLFDD GLGSVAVG-- -EDDGTTFFV KSSLLRRGGP PPPQQMIIQL LDRLYYYYYA TNSLLLLFVV GLGSVYVT-- -EDDDEEEYV KRRLLRRGGP PPPQQMIIQL LDRIYYYYYV TNSLLLLFDD GVESVVLE-- -GEEK---IA KKKIIEEGGP PPPQQMLLQL LDRLYYYYYV TTSLLLLYDD GIETVVLE-- -EDDH---IA KQQIIEEGGP PPPQQMLLQL LDRLYYYYYV STSLLLLYDD ---------- ---------- -------GGP PPPAAKIIQV VDRLYYYYYV TNSFFFFYDD GIDARVLN-- -DPPEKKEPP KRRLLLLGGP PPPQQMLLQL LDRLYYYYYV SSSLLLLFDD GIDLNIVKEE EDKKEKKEPA KRRLLEEGGP PPPQQMLLQL LDRLYYYYYV SSSLLLLYDD ---------- ---------- ---------- ---------- ---------- ---------- RV-------- ---------- ---------- -----MVVSW WDRVYYYYYF SSSLLLLLDD AV-------- ---------- ---------- -----MVVSW WDRLYYYYYY TSSLLLLLDD QYPPELKWMV VN--SSSSGG GLLLDDEFFF DEE------H HQVRLLLSSG GGGDSSDDYY QYPP-LRWMA AN--EEEEGG GLLLEEEFFF DRR------H HQVRLLLWWG GGGDSTDDFF QYPPDVPAQV VG--DDDDGG GLLLAADYYW EDDGG----H HQIRLLLEEG GGGDSTDDFF QYPPDVPVEV VG--NNNNGG GLLLDDDYYF SDDGG----H HQIRLLLEEG GGGDSTDDFF QYPPGRGAMV VG--NNNNGG GLLLDDDFFW DAAGG----H HQIRLLLEEG GGGDSTDDFF QYPPEIDWMV VG--NNNNGG GIIIDDKFFF EKKGG----H HQVRLLLQQG GGGDSSDDYY QYPPDIKWMV VN--DDDDGG GMMMDDNFFF DEE------H HQIRLLLQQG GGGDSSDDYY QYPPVIRWIA AD--GGGGGG GLLLDDGFFF EDDGG----H HQIRLLLEEG GGGDSSDDYY QY--PLIEGS SVDVNNNNGG GLLLNNNFFL DKKEEPGPPH HELRYYYPPG GGGDSSDDWW QY--PLIEGS SIDVNNNNGG GLLLNNNFFL DKKEEPGPPH HELRYYYPPG GGGDSSDDWW QY--PLIEGS SIDVKKKKGG GLLLNNNFFL DKKEEPGPPH HELRYYYPPG GGGDSSDDWW QY--PLIEGS SIDVKKKKGG GLLLNNNFFL DKKEEPGPPH HELRYYYPPG GGGDSSDDWW QY--PLIEGS SVDVKKKKGG GLLLNNNFFL DKKEEPGPPH HELRYYYPPG GGGDSSDDWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QY--PLIEGS SVDVKKKKGG GLLLNNNFFL DKKEEPGPPH HELRYYYPPG GGGDSSDDWW QY--PLIEGS SIDVKKKKGG GLLLNNNFFL DKKEEPGPPH HEIRYYYPPG GGGDTSDDWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QY--PMIEGS SIDVKKKKGG GLLLNNNFFL DKKEEPGPPH HELRYYYPPG GGGDSSDDWW QY--PLLEGA AIDVKKKKGG GLLLNNNFFL DKKEEPGPPH HEIRYYYPPG GGGDTSDDWW QY--PLVKGS SIDVKKKKGG GLLLNNNFFF DAAEEPGPPH HEMRYYYPPG GGGDTSDDWW QY--PLVQGS SIDVNNNNGG GLLLNNNFFF DAAEEPGPPH HEMRYYYPPG GGGDTSDDWW QY--PLMKGS SIDVKKKKGG GLLLNNNFFF DDDEEPGPPH HEMRYYYPPG GGGDTSDDWW SY--PIMKGS SIDGKKKKGG GLLLNNDFFF DDDEEPGPPH HEMRYYYPPG GGGDTSDDWW QYGGQLVKGS SIDVKKKKGG GLLLNNNFFF DAAEEPGPPH HEMRYYYPPG GGGDTSDDWW QY--PHVSGA AVNISSSSKK KMMMNNDFFL DKKIIEGPPH HEMRYYYPPG GGGDTSDDWW QY--PNVSGA AIDVTTTTHH HMMMNNNFFL DKKVVPGPPH HEMRYYYPPG GGGDTSDDWW QY--PVVEGS SIDVKKKKGG GLLLNNNFFL DKKEEPGPPH HDIRFFFPPC CCGDTSDDLL QY--PMVAGG GLDINNNNGG GMMMNNNFFL DGGEEPGPPH HEMR------ ---------- QY--PMVQGG GIDVNNNNGG GIIINNDFFL DNNEEPGPPH HEMRYYYPPG GGGDTSDDWW ---------- ---------- ---------- ---------- ---------- ---------- -------KGK KYLKWWWWGG GKKKVVDFFA DEELLGG--H HIMRFFFGGS SSSAYSSS-- -------KGK KFLKWWWWGG GKKKKKQFFA DAAEEKG--H HQMRFFFGGA AARAYAGGAA P------ P------ PVV---- PVV---- PVV---- P------ P------ P------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- NAA---- ------- ------- GRRQAAV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NSKKKAAKKK PPPSAPCRAA VGLTTAAARL DDDGAAAMMQ SSLLPRRTTQ QLLLLLLLPG gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPPVVRRIII YYQQQEAAWS AAIIQPPPES SSKRTTTRSS SSLVVIIIIS SSVVVVVQAV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMAAAGRSAP PPLLNPPPNP PPLPSSSPPP PPVPPTTTTR LLTTTIIPRL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M PPKRDPYYPS PKKMMAMMKA PLLYCCTTTI ---------- ---------- ---------- KKKPDPYYPT PRRDDAMMRA PIIYAAVTTV ---------- ---------- ---------- SSRPDPHHAS PEELLAMMQA PFFYLLPFF- ---------- ---------- ---------- TTRPDPHHAS PKKLLAMMEA PFFYLLPFF- ---------- ---------- ---------- TTRPDPYYPS AKKLLAMMEG PLLFMMPAA- ---------- ---------- ---------- TTKPDPYYPS PRRLLAAAKA PIIYMMPRR- ---------- ---------- ---------- TTRPDPYYPS PRRMMAVVKA PLLYRRPAAG ---------- ---------- ---------- SSRPDPYYPS PKKMMAMMQA PLLYLLPRR- ---------- ---------- --------AT KK-CGPPPTP LEEAAMKK-G PIIYCCRTTT ---------- ---------- ---------- ---------- ------MM-G PIIYCCRTTI VVAAHWWPPP GKHAAAVVII APPLPG--ST KK-CGPPPSP LEEAAMKK-G PIIYCCGTTI ---------- ---------- ---------- ---------- -----MKK-G PIIYCCRTTI ---------- ---------- --------AT NN-CGPSSTP LEEAAMKK-G PIIYCCRTTT -------AEE RAEAFFTTQQ SVVMPIAAAT NN-CGPSSTP LEEAAMKK-G PIIYCCRTTT ---------- ---------- --------AT NN-CGPSSTP LEEAAMKK-G ---------T ---------- ---------- --------AT NN-CGPSSTP LEEAAMKK-G PIIYCCRTTT ----MGGGKK EEPHTTAAPP WFFQWQEEAT DD-CGPPPTP QEEAAMKK-G PIIYCCRTTT --LLKNNQGG CLGDQQTTTT ELLCLVFFPT NN-CGPSSTP LEEAAMKK-G PIIYCCRTTT ---------- ---------- --------AT NN-CGPSSTP LEEAAMKK-G PIIYCCRTTT LLPPPHHRHH SLVQHHIIEE GAAEAAAAGK HHAKGPAATP LEEAAMEEKG PLLYCCNTTI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MA SS-CGPKKSP LDDAAMKK-G PIIYCCRTTI ---------- --------AA TVVGVNEES- CCKSGPAASP IEESSMSS-G PLLYAAATTI ---------- --------GG TVVAVSEENN CCKSGPAASP LEEAAMSS-G PLLYAAATTI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLVGGPAATP LAAAAMSS-G PLLYAATTTI ---------- ---------- ----AAAAGA GGATGPAATP LEEAAMEEKG PLLYCCNTTI ---------- ---------- ----MSPPGL GG--GPAASP ADDAAIKK-G PVVFAA-NNA ---------- ---------- ----MP--PL GG--GPAASP ADDAAIKK-G PVVFAA-HHR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M KKKCGPAATP LDDAAVRRNG PLLYCCPLLE ---------- ---------- ---------- ---------- -----MRRSG PLLYTTPLLE ---------- ---------- ---------- ----MPIIT- -DDIILIISL DLLFWWGIIQ -------KRR REF------- ---LAG--AM FFAFADCCQS PYYMMPKKIT GFFYTTVGGG -------KRR FIVGPPSSHH FAALSGLLAL AAVRADCCAS PYYMMKKKIT GYYYTTAGGG INADFFIAAA VVVVNSSTTT YSSKKKHELL PYNNNDEELF WWWWWWCSSS ANNGPNIIPG VNPDFFLAAA VVVVDSSTTT YGGKKKYDLL PYGGGDEELF WWWWWWCSSS ANNAPFLIPA --PDAALAAA IIVVKSSTTT YGGKKKHTMM PNGGGDEEFF WWWWWWCSSS SLLTAFLIPG --PDAALAAA IIVVKSSTTT YGGQQQHTMM PNGGGDEEFF WWWWWWCSSS ALLAAFIIPG --PDGGLAAA VVVVDSSKKK FGGQQQHIMM PNGGGDEEFF WWWWWWCSSS ALLTAFLIPG --PDAAIAAA VVVVDSSRRR YAASSSGAMM PHGGGDEELF WWWWWWCSSS CNNAPHMVPG G-PDAAMCCC VVVVDSSTTT FGGQQQGDMM PYGGGGEELF WWWWWWCSSS MNNAPHVVPD --PDAALGGG LLLLDSSTTT YAAQQQGEMM PNAAADEELF WWWWWWCSSA AYYAPHVIPG TEPDYYLAAA VVVVDSSQQQ YSSQQQHPMM PYKKKDEELS WWWWWWCSSS C--FSTKIPG IEPDYYLAAA VVVVDSSHHH YSSQQQHPMM PHKKKDEELS WWWWWWCSSS C--FSTKIPS IEPDYYLAAA VVIIDSSQQQ YCCQQQHPMM PNRRRDEELS WWWWWWCSSS C--FSTKMPC IEPDYYLAAA VVVVDSSQQQ YCCQQQHPMM PHKKKDEELS WWWWWWCSSS C--YITKVPA TEPDYYLAAA VVVVDSSQQQ YCCQQQHPMM PNKKKDEELS WWWWWWCSSS C--FSTKVPS TEPDYYLAAA VVVVDSSQQQ YCCQQQE--- ---------- ---------- ---------- TEPDYYLAAA VVVVDSSQQQ YCCQQQHPMM PNKKKDEELS WWWWWWCSSS C--FSTKVPS TEPDYYLAAA VVVVDSSQQQ YCCQQQHPMM PNKKKDEELS WWWWWWCSSS C--FSTKVPS TEPDYYLAAA VVVVDSSQQQ YSSQQQHPMM PYKKKDEELS WWWWWWCSSS C--FSTKVPS TEPDYYLAAA VVVVDSSQQQ YCCQQQHPMM PNKKKDEELS WWWWWWCSSS C--FSTKVPS TEPDYYLAAA VVVVDSSQQQ YCCQQQHPMM PNKKKDEELS WWWWWWCSSS C--FSTKVPS INLDYYLAAA VVLLDSSTTT YSSQQQHPVV IHGGGDKKLS WWWWWWCSSS C--HPSAIPS ---------- ---------- --------MM PNNNNDEELS WWWWWWCSSS C--YASKIPC INPDYYLAAA VVVVDSSSSS YSSQQQHPMM PNNNNDEELS WWWWWWCSSS C--YSSKIPC IEPDYYLAAA VVVVDSSTTT YSSKKKHPVV PYGGGDEELT WWWWWWCSSS C--HPSAIPS IEPDYYLAAA VVLLDSSTTT YSSKKKHPVV PYGGGDEELT WWWWWWCSSS C--HPSAIPG ---------- ---------- --------MM PFGGGDEELS WWWWWWCSSS C--HASAVPS IDPDYYLAAA VVVVDSSSSS YSSSSSHPMM PFGGGDEELS WWWWWWCSSS C--HASVVPS INPDYYLGGG VVVVDSSTTT YSSQQQHPVV THGGGDEELS WWWWWWCSSS C--HPSAIPS ADPDAAIFFF VVVVNSSTTT FCCQQQSDVV PHGGGDEEVT WWWWWWCSSS C--HPTEIPC RDPDAAIFFF VVVVNSSTTT FCCQQQSDVV PNGGGDEEVT WWWWWWCSSS C--HPTEIPC ---------- ---------- ---------- ---------- ---------- -------VRK EEGDYYLAAA VVVVDSSTTT YCCQQQHYTT NSHHHNEELS WWWWWWCSSS C--GEVPVPC EPGDYYLSSS VVVVDSSTTT YCCQQQHFTT NRGGGDEELS WWWWWWCSSS CEESTVPVPS QYITDDRKKK PPMMVVVLLL GGGSSSKPVV KVEEEDKKES PPPPPPRIIL K---RVQLLS GDQDKKLVVV IILLRSSTTT RGGQQQNSVV GGRRRNEEAG FFFFFF---- -------WGG GDQDKKLVVV VVAANSSQQQ YGGKKKNSVV GGRRRNEEAS FFFFFF---- -------WGG GLRSSSSRYY IIIIDTTPRE IIIIKVIEPP VKSGGRRRLH HTVVHHCGAA IIIALLGEEE ALRSSSSRYY IIVVDTTPRR VAAAKIVEPP AVTGGKKKYH HTVVHHCGAA IIIALLGPPP GLRSSSSRYY VVIIDTTPTQ IHHHKIIEPP ILTGGRRRPH HTVVHHCGGG IIITLLGAAA GLRSSSSRYY IIIIDTTPTK IHHHKIIEPP VFTGGRRRPH HTIIHHCGGG IIITLLGGGG GIRSSSSRYY IIVVDVV-LK IHHHKIIEPP VFTGGRRRPH HTIIHHCGGG IIITLLGGGG GLRSSSSRYY IILLDTTPLK LAAAKVIEPP LATGGRRRPH HTVVHHCGGG IIIALLGAAA DIRSSSSHTT IILLDTTPTQ VVVVKVIDPP LATGGRRRPH HTVVHHCGGG IIIALLGPPP GIRSSSSRHH IIVVDTTPRE IVVVKVIEPP LHTGGRRRPH HTIIHHCGGG VVVALLGPPP GLMSSSSRYY VVVVDVVSRA LHHHKVIEAA IQCNNNNNTH HTSSHHCLGG EEENTTLDDD SIISSSSRYY VVVVDVVSRA LHHHKVIEPP IHCNNNNNLH HTSSHHCLGG EEESSSLDDD CLMSSSSRYY VVVVDVVSRA LHHHKVIEAA IHCGGYYYVH HTSSHHCLGG EEESTTLDDD ALISSSSRYY VVVVDVVTRA LHHHKVIEPP IHCNNFFFFH HTSSHHCLGG EEESTTLDDD SLISSSSRYY VVVVDVVSRA LHHHKVIEPP IHCEEFFFLH HTSSHHCLGG EEESSSLDDD ---------- ---------- --------PP IHCEEFFFLH HTSSHHCLGG EEESSSLDDD SLISSSSRYY VVVVDVVSRA LHHHKVIEPP IHCEEFFFLH HTSSHHCLGG EEESSSLDDD SLISSSSRYY VVVVDVVSRA LHHHKVIEPP IHCEEFFFLH HTSSHHCLGG EEESSSLDDD SFISSSSRYY VVVVDVVTRA LHHHKVIEAA IHCGGTTTPH HTSSHHCLGG EEESTTLDDD SL-------- ---------- ---------- ---------- ---------- ---------- SLISSSSRYY VVVVDVVSRA LHHHKVIEPP IHCEEFFFLH HTSSHHCLGG EEESSSLDDD SLLSGGGRYY VVVVDTTTRT LHHHKVVESS IAIGGFFFPH HTSSHHCLGG DDDSCCLDDD CLISSSSRYY VVVVDVVTRA IHHHKTVEPP VFCGGNNNLH HTSSHHCLGG EEESSSIDDD CLISSSSRYY VVVVDVVSRA IHHHKTVEPP VFCGGNNNPH HTSSHHCLGG EEESSSLDDD SLVSGGGRYY VVIIDTTTRS LHHHKVVDPP IITGGYYYPH HTSSHHCLGG EEESCCLDDD GIVSGGGRYY VVIIDTTTRA LHHHKVVEPP ISTGGYYYPH HTSSHHCLGG EEESCCIDDD SLISGGGRYY AAIIDTTERA LYYYKYVDPP IATGGYYYPH HTAAHHCLGG EEESCCLDDD SLISGGGRYY AAIIDTTERA LYYYKYVDPP IATGGFFFPH HTAAHHCRGG EEESCCLDDD SLLSGGGRYY VVVVDTTKRA LHHHKVVEAA IATGGFFFPH HTSSHHCLGG EEESCCLDDD CLNSDDDRYY IIIINVVNRK LEEEHTIEPP LHN--FFFPH HTSSHHCLGG NNNSTTLEEE CLNSDDDRYY VVIINVVNRE LQQQHTIEPP LHN--FFFPH HTSSHHCLGG NNNSTTLEEE KLSSGGGVGG KKVVFVVG-- ---------- ---------- ---------- ---------- CLNSDDDRFF VVIIDTTTRA LAAAKVIEGG VLADDAAAPH HTTTHHCLGG NNNSIIMDDD SLNSDDDFYY IILLDVVTRK IVVVKTIDGG VLHNNAAAPH HTTTHHCLGG NNNSVVMDDD SLDGKKKRYY VVTTTSSYWD FYYYP----- LILVVIIISH HTAADDYQTT AAADGGVEEE GLDTNNNRFF IIFFDVVSSN LHHHKTIDTT VKGGGGGGPH HTFFFFALSS MMMGLLSDDD GLDTSSSKFF VVFFDVVSAR LSSSKTITDD VEGGGGGGPH HTLLYYALRR MMMGLLSNNN ----GGGEGG GGIIIILMML LLLHSSSEWE IGGGQQQQY- ---------L YFESSSNN-- ----GGGEGG GGIIIIFLLL LLLHTTTEWE VGGGQQQQY- ---------F YFGTSSRR-- GGKKGGGDGG PGIIIIFIIM MMMCTTTDWE IGGGQQQQD- ---------K YFDSSSPP-- GGKKGGGNGG PGVVVVFIIM MMMCTTTEWE IGGGQQQQT- ---------L YFDTSSPP-- GGEEGGGDGG PGIIIIFIIL LLLCTTTEYE MGGGQQQQT- ---------K YFDSSSPP-- ----GGGKGG GGIIIIAMML LLLASSSEWE VGGGQQQQY- ---------F YGDTSSDD-- ----GGGEGG GGIIIIFIIL LLLHNNNEWE IGGGQQQQY- ---------L YFDTSSRR-- ----GGGDGG GGVVVVFVVM MMMHSSSDWE VGGGQQQQQ- ---------L YFDTSSNN-- ----QQQNGG GSFFFFVLLL LLLGTTTEWE KGGGSSSSP- ---------M YFNSTTNN-- ----QQQNGG GGFFFFVLLL LLLGTTTEWE KGGGAAAAP- ---------M YFNSTTNN-- ----KKKNGG GGFFFFVLLL LLLGTTTEWE QGGGAAAAP- ---------M YFNSTTNN-- ----EEENGG GGFFFFVLLL LLLGTTTEWE QGGGAAAAP- ---------L YFNSTTNN-- ----KKKNGG GGFFFFVLLL LLLGTTTEWE RGGGAAAAP- ---------S YFNSTTNN-- ----KKKNGG GGFFFFVLLL LLLGTTTEWE RGGGAAAAP- ---------L YFNSTTNN-- ----KKKNGG GGFFFFVLLL LLLGTTTEWE RGGGAAAAP- ---------L YFNSTTNN-- ----KKKNGG GGFFFFVLLL LLLGTTTEWE RGGGAAAAP- ---------L YFNSTTNN-- ----KKKNGG GGFFFFVLLL LLLGTTTEWE RGGGAAAAP- ---------M YFNSTTNN-- ---------- ---------- ---------- ---------- ---------- ---------- ----KKKNGG DGSSSSLVVL LLLPRRRE-- ---------- ---------- ----AANN-- ----EEENAA GNGGGGFLLL LLLDEEENGS NFFFIIIIS- ---------K RHGSWWLL-- ----YYYNGG GGFFFFVLLL LLLGTTTEWE AEEEAAAAP- ---------F YFNSTTKK-- ----CCCNGG GGFFFFVLLL LLLGTTTEWE VEEEAAAAQ- ---------F YFNSTTKK-- ----DDDNAA GNGGGGFLLL LLLDDDDNWE KHHHPPPPL- ---------F YFNSTTTT-- ----DDDNAA GNGGGGFLLL LLLDEEENWE KHHHPPPPL- ---------F YFNSTTKK-- ----EEENAA GNGGGGFLLL LLLDDDDNWE KHHHPPPPL- ---------F YFKSTTKK-- ----EEENAA GNGGGGLLLL LLLDDDDNWE KIIIPPPPL- ---------Y YFKSTTKK-- ----EEENAA GNGGGGFLLL LLLDEEENWE KHHHPPPPL- ---------F YYKSSSAA-- ----NNNTPP GNFFFFLLLL LLLGTTTEWP AKKKVVVVP- ---------F YFNSTTNN-- ----DDDSPP GNFFFFLLLL LLLGTTTEWP AKKKVVVVP- ---------F YFNSTTNN-- ---------- ---------- ---------- ---------- ---------- ---SIIVV-- ----EEENAA G-DDDDFVVE EEEDNNNEWS RRRRAAAAL- ---------C YYNASSKK-- ----EEEYAA G-DDDDFIIL LLLDDDDNWT KKKKAAAAL- ---------C YFDSSSNN-- ----LLLVPP LNGGGGIQQT TTTKEEEGGE AFFFEEEEI- ---------L LNESDDII-- ----DDDGGG TALLLLVEEY YYYDGGGYWM PDDDMMMMQG GGAAVGDDVY YINTSSSSNN ----DDDGGG TALLLLVEEY YYYNGGGYWI PGGGLLLLRG GGAKTG--YY YVNTSSNNNN TEDDDG-LKD GNNNRIIIWL RRRKRIIIIS LLLTLGENNR RMALL----L LLPPDDPPKL CEEEEG-LKE GNNNKLLLWL AARRHLLLLA IIIDLGQHHR RMVLL----V VVPPDDPPKL QENNNG-LLA GHHHRLLLWL RRRRNVVVVT IIIDLGAHHQ QMALL----V VVPPDDPPRE QENNNG-LLS GHHHRLLLWL RRRRNVVVVT IIIDLGAHHQ QMALL----V VVPPDDPPRE QENNNG-LLS GHHHKIIIWL RRRKNVVVVT IIIDLGAHHQ QMALL----I IIPPDDPPKD MEDDDG-LLG GRRRRLLLWL TTRRHLLLLE IIIDFGDHHQ QLVFF----L LLPPDDPPKA MESSSG-LLA GHHHRLLLWL YYRRHLLLLT LLLDLGAYYQ QMALL----L LLPPDDPPKA MEGGGG-LLN GRRRRLLLWL RRRRHLLLLA LLLDVGEHHQ QMVLL----L LLPPDDPPRT VKDDDGFEA- GSSSRIIIWW QQHEIIIIIT LLLQMT-DDG GLIPP----I IIFFDDPPAT VKDDDGFEA- GSSSHIIIWW QQHEIIIIIT LLLQMK-DDG GLIPP----I IIFFDDPPAT VRDDDGFEA- GSSSHLLLWW QQHEIIIIIT LLLTLQ-DDG GLIPP----I IIFFNNPPAA VRDDDGFKA- GSSSHLLLWW QQREIVVVVT LLLPLQ-DDG GLIPP----I IIFFNNPPAA VRDDDGFEA- GSSSHLLLWW QQHEIVVVVT LLLSLK-DDG GLIPP----I IIFFNNPPAA VRDDDGFEA- GSSSHLLLWW QQHEIVVVVT LLLSLK-DDG GLIPP----I IIFFNNPPAA VRDDDGFEA- GSSSHLLLWW QQHEIVVVVT LLLSLK-DDG GLIPP----I IIFFNNPPAA VRDDDGFEA- GSSSHLLLWW QQHEIVVVVT LLLSLK-DDG GLIPP----I IIFFNNPPAA VQNNNGFEA- GKKKHLLLWW QQHEIVVVVT LLLLMP-DDG GHIPP----I IIFFDDPPAS ---------- ---------- ---------- ---------- ---------- ---------- LLTTTGSSA- AGGGITTT-- ---------- ---------- ---------- ---------- FTTTTGATA- HVVVISSSDY IIRVIDDDDS LLLPLQ-DDQ QAGAANPIIL LLSSWWKKIN AALLLGFQA- GHHHSLLLWW TTHRRIIIIT IIIDLGEDDG GLIPP----I IIFFDDPPAA AALLLGFQA- GHHHSLLLWW TTHRLVVVVT IIIDLGKDDG GLIPP----I IIFFNNPPAD ATKKKGFAD- GRRRHLLLIL AAGELRRRRT LLLDLGNTTG GLLPP----I IIFFDDPPKD ALQQQGFAD- GRRRHLLLYW PPGEIKKKKT LLLDLGDKKG GLLPP----I IIFFDDPPKD ASKKKGFAD- GSSSHLLLYW PPGEMKKKKL IIIDLGETTG GLLPP----I IIFFDDPPKD ASKKKGFAD- GSSSHLLLYW PPGEIKKKKL IIIDLGPTTG GLLPP----I IIFFDDPPKD ARTTTGFQD- GRRRHLLLYW PPGELKKKKT LLLDLGSTTG GLLPP----V VVFFDDPPKD HKKKKGFGE- GNNNSVVVFW DDKKYLLLLT IIIDLPQLLG GALPP----V VVFFEEPPSE HKKKKGFPE- GNNNSVVVFW DDKKHLLLLT IIIDLPMRRG GALPP----V VVFFEEPPSE TCRRRDEPE- IKKKCKKKY- ---------- ---------- ---------- ---------- LRRRRGYDDR GCCCRLLLYW QQRELFFFFT IIIDLGDDDG GLTPP----I IIFFNNPPEN KRRRRGWEDM GCCCRLLLYW SSQTLYYYYT IIIDLGSDDG GITPP----I IIFFNNPPKA MFEEESSKTG PQQQHVVVV- ---------- ---------- ---------- ---------- MDFFFGQEAM GNNNTIIIWL HHRQPKKKKV FFFNVPGPP- ---------I IIFFGGSSAN MDFFFGKEAM GNNNTVVVWL HHKQPKKKKV FFFDVPGPP- ---------I IICCGGEEHN LMGGMVVSLL LLSSSSSIIW FFFY---EKK WNAVIIIPAE ELEEGNLLPE ELKKFFKAVV LMGGVVLNTL LLSSSSSIIW FFFY---EKK WQAVIIIEAQ QFEEGPLLPP PLKKFFKMVV EYGGVVVDTL LLEEEESIIW WWWR---EKK FHVTIIIPAE EATTAELLPP PLQQFFGAVV EYGGVVVDTL LLEEEESIIW WWWR---EKK FHATIIIPPE EAPPKKLLPP PLQQFFGAVV DYGGVVVDTL LLQQQQAIIF WWWQKKKDTT FEATIIIDPV VADDADLLPD DLKKFFGACC AYGGCVISLL LLSSSSSIIW YYYR---DKK WAVVIIIPAE EADDPQLLPP PLKKFFKAVV AYGGCVVSLL LLSSSSSIIW YYYR---DSS WHLVIIIPAE EASSEQLLPP PLKKFFKAVV TYGGVVVSLL LLSSSSSVVW HHHR---QSS WGIVIIIPAE EAEEPQLLPP PLKKFFGAVV TQGGCALSSQ QQRRRRYKKN GGG------- ----SSSVEK KIQQVSKKKV VGWWLLPEMM TQGGCALSSQ QQRRRRYKKN GGG------- ----SSSVEK KIQQVSKKKV VGWWLLPEMM AQGGCALSSQ QQRRRRYKKN GGG------- ----SSSVEK KIQQVPKKKV VGWWLLPEMM AQGGCALSSQ QQRRRRFKKN GGG------- ----SSSAQK KIQQVPKKKV VGWWLLPEMM AQGGCALSSQ QQRRRRYKKN GGG------- ----SSSVEK KIQQVPKKKV VGWWLLPEMM AQGGCALSSQ QQRRRRYKKN GGG------- ----SSSVEK KIQQVPKKKV VGWWLLPEMM AQGGCALSSQ QQRRRRYKKN GGG------- ----SSSVEK KIQQVPKKKV VGWWLLPEMM AQGGCALSSQ QQRRRRYKKN GGG------- ----SSSVEK KIQQVPKKKV VGWWLLPEMM SQGGCALSSQ QQRRRRYKKN GGG------- ----SSSVEK KIEEVPKKKV VGWWLLPEMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NQDDVEVSFR RRGGGGSDDP YYY------- ----VVVLKR RLDDLYAAVV VKFFVVVSLL AQGGCALSSF FFRRRRYKKE GGG------- ----AAAAEK KIKKVSKKKV VGWWLLPEMM DQGGCALSSF FFRRRRYKKE GGG------- ----AAAAEK KIQQVSKKKV VGWWMMPEMM DTGGSALSSI IIRRRRFKKT GGG------- ----SSSHEL LIPPVPLLKV VNWWLLPEMM DTGGSALTSI IIRRRRFKKT GGG------- ----NNNHEI IISSVPLLKV VNWWLLPEMM DTGGSALSSI IIRRRRFKKN DDD------- ----SSSYEI IISSVPLLKV VNWWLLPEMM DTGGSALSSI IIRRRRFKKN EEE------- ----SSSHEV VISSVPLLKV VNWWLLPEMM DTGGCALTSV VVRRRRFKKT GGG------- ----SSSHEV VISSIPLLKV VNWWLLPEMM EHAACALGSF FFRRRRHPPV NNNS------ ----AAAATL LAFFISKKKV VGWWLLPEMM EHAACALGSF FFRRRRHPPD NNNP------ ----TTTASL LATTISKKKV VNWWLLPDMM ---------- ---------- ---------- ---------- ---------- ---------- NQGGCAFXXX XXXXXXX--- ---------- ---------- --------QG GNGGIIEMMM AEGGCALNAF FFHHHHKKKK SSSD------ ---FKKKKVI IIPPGLVVDT TSGGAAEDMM ---------- ---------- ---------- ---------- ---------- ---------- NYAATALTSW WWLLLLYEED GGG------- ---------- --EEWAKKAV VDIINNPADD NYCCTALTSW WWLLLLYEED GGG------- ---------- --EEWAKKAV VDIIEEPAKK TDIIILLDKF YLLLLLWWGG EVVRQQQQQD SSNPFPVVVL LLGGKVLLLL GGGIFHAAAD TDIIILLDRF YVVLLLWWGG ELLRQQQQQD TTNPHPRRRL LLGGRVIIII GGGLYHEEEP TDILLLLDRF YVVCCCWWGG EMMRQQQQQD SSDPHPVVVL LLGGSVIIII GGGIARAAAP TDILLMMDRF YVVCCCWWGG EMMRQQQQQD SSDPRPKKKL LLGGSVIIII GGGIARTTTP TDILLLLDKY YVVCCCWWGG EMMHQQQQQD SSDPMPVVVL LLGGKVIIII GGGIVKTTTP TDILLMMDRF YVVCCCWWGG DLLLQQQQQD SSDPFPKKKL LLGGKVIIII GGGIVSAAAT TDILLVVDRF YVVCCCWWGG ELLHQQQQQD SSDPFPRRRL LLGGKVIIII GGGIVRAAAG TDILLLLDRF YVVCCCWWGG ELLRQQQQQD SSDPFPRRRH HHGGSVLLLL GGGIVRAAAA TDILLLLDRF YFFNNNWWLL DIIRQQQQQD SSNPQPRRRL LLGGQILLLL GGGSIVGGGG TDILLLLDRF YFFNNNWWLL DIIRQQQQQD SSNPKPRRRL LLGGQILLLL GGGSIVGGGG TDILLLLDRF YFFNNNWWLL DLLRQQQQQD SSDPQPRRRL LLGGQLLLLL GGGSIVGGGG TDILLLLDHF YFFNNNWWLL DIIRQQQQQD SSDPQPRRRL LLGGQLLLLL GGGSIVDDDG TDILLLLDRF YFFNNNWWLL DLLRQQQQQD SSDPQPRRRL LLGGQLLLLL GGGSIVGGGG TDILLLLDRF YFFNNNWWLL DLLRQQQQQD SSDPQPRRRL LL-------- ---------- T--------- ---------- ---------- ---------- ---------- ---------- TDILLLLDRF YFFNNNWWLL DLLRQQQQQD SSDPQPRRRL LLGGQLLLLL GGGSIVGGGG TDILLLLDRF YFFNNNWWLL DMMRQQQQQD SSDPKPRRRL LLGGQILLLL GGGSIVGGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPAIIFFDLL IFFSSS---- ---------- ---------- ---------- ---------- TDIIILLDRF YFFNNNWWLL DIIRQQQQQD TTDPRPKKKL LLGGQILLLL GGGSILGGGG TDIIILLDRF YFFNNNWWLL DIIRQQQQQD TTDTRPKKKL LLGGQILLLL GGGSIQGGGG TDFIILLDRF YFFNNNWWLL DIIRQQQQQN EEDLKPVVVL LLGGQLVVVV GGGLIQGGGS TDFIILLDRF YFFNNNWWLL DIIRQQQQQN EEDVKPKKKL LLGGQVAAAA GGGLIQGGGS TDFIILLDRF YFFNNNWWLL DIIRQQQQQN EEDPKPVVVL LLGGQIVVVV GGGLLQGGGS TDFIILLDRF YFFNNNWWLL DIIRQQQQQN EEDPKPVVVL LLGGQIVVVV GGGLLQGGGS TDFIILLDRY YLLNNNWWLL DIIRQQQQQN EEDPAPVVVL LLGGQVAAAA GGGLLQGGGS TDIIIMMDRF YVVCCCWWLL DIIRQQQQQD SSDPLVKKKL LLSSQVIIII GGGSVHEEES TDIIIMMDRF YVVCCCWWLL DIIRQQQQQD SSDPKPKKKL LLSSQVIIII GGGSIHEEET ---------- ---------- ---------- ---------- ---------- ---------- TDIIILLDRY YFFNNNWWRR DVVRQQQQQD SSDRAPRRRL LLGGQVLLLL GGGAIQDDDA SDIIILLDRF YVVCCCWWRR DVVRQQQQQD TTDPEPKKKL LLGGQLLLLL GGGAICDDDL ---------- ---------- ---------- ---------- ---------- ---------- VDIIIAADQT WIISSSFFMM KTTRLLLLLD SSDPHPFFFQ QQYYEKIIII DDRQVN---- VDIIINNDSR WVVTTTFFMM KTTRLLLLLD SSDPHPRRRQ QQYYEKIIII GGAQVN---- DD-------- ---------- ---AHLLGQM MEISRRDRVY VVTLLTTWWD DNNNQQFEEE PP-------- ---------- ---SAAAGQM MSVSRRDRVY IITLLSSWWN NNNNQQF--- PP-------- ---------- ---NRFFGQM MEISRRDRVY WWTLLTTWWD DDDDQQFDDD PP-------- ---------- ---NKFFAQM MEISRRDRVY WWTLLTTWWD DDDDQQFDDD PP-------- ---------- ---NKFFYQM MEISRRDKVY WWTLLTTWWD DEEEQQFGGG TTGG------ ---------- ---KGLLGQM MEISRRDRVY FFTLLAAVVD DPPPQQFEEE GG-------- ---------- ---TALLGQM MEISRRDRVY FFTLLAAWWD DEEEQQFDDD AA-------- ---------- ---AGLLGQM MEVSRRDRVY FFSLLSSWWD DEEEQQFVVV GGQQLL-DDD DQTQQQQPPP EPLKKIIGQM MQLSLLDKLY AATLLDDWWD DKKKQQFPPP GGQQLL-DDD DQTQQQQPPP EPLKKVVGQM MQLSLLDKLY VVTLLAAWWD DKKKQQFPPP GGQQLL-DDD DQKQQQQPPP EPLKKVVGQM MQLSLLDKLY VVTLLAAWWD DKKKQQFPPP GGQQLL-DDD DQDQQQQPPP EPLKKVVGQM MQLSLLDKLY VVTLLAAWWD DKKKQQFPPP GGQQLL-DDD DQKQQQQPPP EPLKKVVGQM MQLSLLDKLY IITLLAAWWD DKKKQQFPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGQQLL-DDD DEKQQQQPPP EPLKKVVGQM MQLSLLDKLY IITLLAAWWD DKKKQQFPPP GGQQLL-DDD DQKQQQQPPP EPLKKVVGQM MQLSLLDKIY VVTLLDDWWD DKKKQQFPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGTTLL-DDD DKEQQQQPPP DPVKKVVGQM MQLSLLDKLY VVTLLKKWWD DKKKQQFPPP GGTTLL-DDD DKEQQQQPPP DPVKKIIGQM MQLSLLDKIY VVTLLIIWWD DKKKQQFPPP SSAAII-EEE EDTQQQQSSS DVPQQLLGQM MQLTLLDKLY VVTLLAAWWD DKKKQQFPPP SSVVVV-DDD DDTQQQQSSS DVPQKLLGQM MQLSLLDKLY VVTLLAAWWD DKKKQQFPPP SSKKVV-EEE EDSQQQQFFF DVPKKLLGQM MQLSLLDKLY AATLLAAWWD DRRRQQFPPP SSKKVV-EEE EDTQQQQFFF EVPKKLLGQM MQLSLLDKLY AATLLAAWWV VVVVSSFPPP SSVVVV-EEE EDEQQQQYYY SVPKHLLGQM MQLSLLDKIY VVTLLRRWWD DEEEQQFQQQ SSKKLL-GGG GE-PPPPIII EALKRIIGQM MQLSLLDKLY VVTLLKKWWD DDDDQQFPPP TTKKLL-EEE ED-EEEEIII PALKRIIGQM MQLSLLDKLY VVSLLKKWWD DDDDQQFPPP ---------- ---------- -------GAK KQLSVVDKLY VVTFFTTWWD DKKKQQFPPP AARRLL-DDD DPKAAAAPPP EPVKRLLGQM MQLSLLDRLY VVSLLPPWWD DKKKQQFPPP LLVVVVEDDD DKKRRRRPPP PARKRLLGQM MQLSLLDKLY VVSLLPPWWD DKKKQQFPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M MSQSWWDKVY FFSLLNNWWD D--------- ---------- ---------- ---------M MSSSWWDQLY YYTLLNNWWD D--------- KKGGWWVVKL NN----SSLL EEEEIIDKFV VDDG-----A SVVRRLLGGG DDASDDD--- RRGGWWAAKV NN----EELL EEEELLEKFV VDDG-----A AVVRRLLGGG DDASDDD--- PPAAAAVVLA HG----DDLL TTTTLLADWV VEEPG----Y AIIRRLLGGG DDCSDDDSVK PPGGVVVVMA NG----NNLL EEEELLDKFV VSSPG----Y AIIRRLLGGG DDCSDDDSV- GGAAAAVVMA NG----NNLL TTTTLLDKWV VDDPG----Y SIIRRLLGGG DDCSDDDSV- DDGGWWVVKL DG----NNII EEEEFFDPFL LEEPG----H PVVRRLLGGG DDCSDDD--- KKGGWWVVKV DN----DDMM QQQQFFDPFV VDDG-----Q VIIRRLLGGG DDASDDD--- RRGGWWAAKA ED----GGLL SSSSLLDPFT TEEGG----L PIIRRLLGGG DDSSDDDS-- IIRREESSVM LVDVDTNNLL KKKKLLNPLV VDDGEPPLPA ALLRRYYGGG DDCSDDD--- IIRREESSVM LIDVDTNNLL KKKKLLNPLV VDDGEPPLPA ALLRRYYGGG DDCSDDD--- IIRREESSVM LIDVDTKKLL KKKKLLNPLV VDDGEPPLPA ALLRRYYGGG DDCSDDD--- IIRREESSVM LIDVDTKKLL TTTTLLNPLV VDDGEPPLPA ALLRRYYGGG DDCSDDD--- IIRREESSVM LVDVDTKKLL KKKKLLNPLV VDDGEPPLPA ALLRRYYGGG DDCSDDD--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIRREESSVM LVDVDTKKLL KKKKLLNPLV VDDGEPPLPA ALLRRYYGGG DDCSDDD--- IIRREESSVM LIDVDTKKLL KKKKLLNPLV VDDGEPPLPA AIIRRYYGGG DDCTDDD--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIKKEESSVM LIDVDTKKLL KKKKLLNPLV VDDGEPPGPV ALLRRYYGGG DDCSDDD--- LLKKEEAAVM LIDVDTKKLL KKKKLLNPLV VDDGEPPDPV AIIRRYYGGG DDCTDDD--- VVEEKKSSHI LIDVDTKKLL KKKKIINPFV VDDGEPPDPA AMMRRYYGGG DDCTDDD--- VVEEQQSSHI LIDVDTNNLL KKKKIINPFV VDDGEPPDPS AMMRRYYGGG DDCTDDD--- MMDDKKSSHI IIDVDTKKLL SSSSIINPFV VDDGEPPEPA AMMRRYYGGG DDCTDDD--- MMEEKKSSHI IIDGDTKKLL TTTTIINPFV VDDGEPPDPS AMMRRYYGGG DDCTDDD--- VVKKKKSSHM LIDVDTKKLL SSSSIINPFV VDDGEPPEPS AMMRRYYGGG DDCTDDD--- VVKKSSAATM VVNIDPSSMM EEEEIINRLI IDDGIEEGPY AMMRRYYGGG DDCTDDD--- VVRRSSAATM LIDVDPTTMM VVVVIINKLI IDDGVPPGPY AMMRRYYGGG DDCTDDD--- VVKKEESSVM LIDVDTKKLL TTTTVVNKLV VDDGEPPNPC AIIRRFFGGG DDSTDDD--- VVAAAAGGTI VLDIDVNNMM KKKKLLNELV VDDGEPPYPG PMMRR----- ---------- VVSSQQGGHI VIDVDTNNII SSSSLLNELV VDDAEPPYPS PMMRRYYGGG DDCTDDDDA- ---------- ---------- ---------- ---------- ---------- ---------- --KKKKKKDD AYLKAYWWKK EEEELLVEAV VDDYLGGL-- AMMRRFFSSS AALYSSS--- --KKKKKKDD EFLKLYWWKK EEEELLKEAI IDDYEKKL-- PMMRRFFRRR AALYGGGNRL ------- ------- KKKK--- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLLLQRE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNNSAAKQSE ETCCTTAVPP LLAARLLAAA DQSLLPTTTT AAAALLLLLL PSVIKKAYEA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -------MGS gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAWTFSSSSA IQQVAASPPP PRRSESSSKK KRKKKKTTTV PPPGVESSVA QQVVVVVPQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSAPTLPPPP LNNNTTTPPP PHHPNPPPLL LPAAAASSSH PPPRPLRLRP RRTTIIINPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A PPTFPPKMMM MMKKAAAPPL YYYYYVVAAC ---------- ---------- ---------- KKTFPPRDDD DMRRAAAPPI YYYYYVVAAA ---------- ---------- ---------- SSTFAPELLL LMQQAAAPAF YYYYYTTLLL ---------- ---------- ---------- TTTFAPKLLL LMEEAAAPAF YYYYYTTLLL ---------- ---------- ---------- TTTFPAKLLL LMEEGGGPVL FFFFFTTLLM ---------- ---------- ---------- TTSFPPRLLL LAKKAAAPPI YYYYYVVAAM ---------- ---------- ---------- TTTFPPRMMM MVKKAAAPAL YYYYYVVVVR ---------- ---------- ---------- SSTFPPKMMM MMQQAAAPRL YYYYYVVAAL ---------- ---------- --------AK KKGYTLEAAA AK--GGGPRI YYYYYLLPPC ---------- ---------- ---------- ---------- -M--GGGPRI YYYYYLLPPC AAVVQAHLLP GGGGAAAIAR GLLPPPPASQ KKGYSLEAAA AK--GGGPRI YYYYYLLPPC ---------- ---------- ---------- ---------- -K--GGGPRI YYYYYLLPPC ---------- ---------- --------AK NNGYTLEAAA AK--GGGPRI YYYYYLLPPC ---------A RRRGAAFQSQ PMRPPPPSAK NNGYTLEAAA AK--GGGPRI YYYYYLLPPC ---------- ---------- --------AK NNGYTLEAAA AK--GGG--- ---------- ---------- ---------- --------AK NNGYTLEAAA AK--GGGPRI YYYYYLLPPC ------MLLG EEEGHHTPWS GQLWWWWDAK DDGYTQEAAA AK--GGGPRI YYYYYLLPPC -----LKSSQ CCCFDDQTET YCTLLLLTPK NNGYTLEAAA AK--GGGPRI YYYYYLLPPC ---------- ---------- --------AK NNGYTLEAAA AK--GGGPRI YYYYYLLPPC PRLLPPPAAR SSSLQQHEGA VETAAAAAGT HHGYTLEAAA AEKKGGGPRL YYYYYVVTTC ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MK SSGYSLDAAA AK--GGGPRI YYYYYLLPPC ---------- -------ATD HGVVVVVKSV CCGYSIESSS SS--GGGPRL YYYYYVVTTA ---------- -------GTQ HAVVVVVKNQ CCGYSLEAAA AS--GGGPRL YYYYYVVTTA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLGYTLAAAA AS--GGGPSL YYYYYVVTTA ---------- ---------- --MAAAAAGA GGGYTLEAAA AEKKGGGPRL YYYYYVVTTC ---------- ---------- ---MMMMNGK GGGYSADAAA AK--GGGPRV FFFFFVVTTA ---------- ---------- ---MMMM-PK GGGYSADAAA AK--GGGPRV FFFFFVVTTA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------S KKGYTLDAAA ARNNGGGPVL YYYYYVVVVC ---------- ---------- ---------- ---------- -RSSGGGPRL YYYYYTTVVT ---------- ---------- ---------- --GLT-DIII IISSLLLDDL FFFFFSSNNW -------MMK RRRG------ ALAAAAAAAG FFETQPYMMM MKIITTTGQF YYYYYVVWWT -------MMK FFFSGGPHFR ALVSSSSAAA AAETAPYMMM MKIITTTGQY YYYYYVVWWT LLYTTTGGTT IDDDFFIAVD NPPTTTYSVK KEEEEELPYN DEELHHHHHH HFGWWNACCS LLYVVVGGTT VDDDFFLAVD DPPTTTYGIK KDDDDDLPYG DEELHHHHHH HFGWWNACCS LLSPPPDDFF -DDDAALAID KPPTTTYGVT TTTTTTMPNG DEEFHHHHHH HFGWWNACCS LLSPPPDDFF -DDDAALAID KPPTTTYGVT TTTTTTMPNG DEEFHHHHHH HFGWWNACCS LLSPPPDDAA -DDDGGLAVD DPPKKKFGVQ QIIIIIMPNG DEEFHHHHHH HFGWWNACCS FFDPPPEERR -DDDAAIAVD DPPRRRYAVQ QAAAAAMPHG DEELHHHHHH HFGWWNACCS LLNPPPMMAA GDDDAAMCVD DSSTTTFGVV VDDDDDMPYG GEELHHHHHH HFGWWNACCS LLDPPPGGRR -DDDAALGLD DPPTTTYAVR REEEEEMPNA DEELHHHHHH HFGWWNACCS IIYRRRNNTT TDDDYYLAVD DPPQQQYSIR RPPPPPMPYK DEELHHHHHH HSGWWNTCCS IIYRRRNNTT IDDDYYLAVD DPPHHHYSIR RPPPPPMPHK DEELHHHHHH HSGWWNTCCS IIYGGGNNTT IDDDYYLAVD DPPQQQYCIR RPPPPPMPNR DEELHHHHHH HSGWWNACCS IIYRRRNNTT IDDDYYLAVD DPPQQQYCIR RPPPPPMPHK DEELHHHHHH HSGWWNTCCS IIYRRRNNTT TDDDYYLAVD DPPQQQYCIR RPPPPPMPNK DEELHHHHHH HSGWWNTCCS IIYRRRNNTT TDDDYYLAVD DPPQQQYCI- ---------- ---------- ---------- ---------- TDDDYYLAVD DPPQQQYCIR RPPPPPMPNK DEELHHHHHH HSGWWNTCCS IIYRRRNNTT TDDDYYLAVD DPPQQQYCIR RPPPPPMPNK DEELHHHHHH HSGWWNTCCS IIYRRRNNTT TDDDYYLAVD DPPQQQYSIR RPPPPPMPYK DEELHHHHHH HSGWWNTCCS IIYRRRNNTT TDDDYYLAVD DPPQQQYCIR RPPPPPMPNK DEELHHHHHH HSGWWNTCCS IIYRRRNNTT TDDDYYLAVD DPPQQQYCIR RPPPPPMPNK DEELHHHHHH HSGWWNTCCS VVYNNNGGTT IDDDYYLAVD DPPTTTYSIR RPPPPPVIHG DKKLHHHHHH HSGWWNSCCS ---------- ---------- ---------- ------MPNN DEELHHHHHH HSGWWNTCCS IIYRRRSSTT IDDDYYLAVD DPPSSSYSIR RPPPPPMPNN DEELHHHHHH HSGWWNTCCS VVYAAAGGTT IDDDYYLAVD DPPTTTYSIR RPPPPPVPYG DEELHHHHHH HTGWWNSCCS VVYAAAGGTT IDDDYYLAVD DPPTTTYSIR RPPPPPVPYG DEELHHHHHH HTGWWNSCCS ---------- ---------- ---------- ------MPFG DEELHHHHHH HSGWWNSCCS VVYTTTGGTT IDDDYYLAVD DPPSSSYSIR RPPPPPMPFG DEELHHHHHH HSGWWNSCCS VVYNNNGGTT IDDDYYLGVD DPPTTTYSIR RPPPPPVTHG DEELHHHHHH HSGWWNACCS PP------NN ADDDAAIFVD NPPTTTFCIR RDDDDDVPHG DEEVHHHHHH HTGWWNACCS PP------HH RDDDAAIFVN NPPTTTFCIR RDDDDDVPNG DEEVHHHHHH HTGWWNACCS ---------- ---------- ---------- ---------- ---------- ---------- VVQPPPNNLL EDDDYYLAVD DPPTTTYCIR RYYYYYTNSH NEELHHHHHH HSGWWNTCCS VVQPPPNNLL EDDDYYLSVD DPPTTTYCVR RFFFFFTNRG DEELHHHHHH HSGWWNACCS LLHGGGDDII QTTTDDRKPR VGGLLLGGLD DPPPPPVKVE DKKELLLLLL DSQPPTPRRI LLGVVVEEGG GDDDKKLVID RPPTTTRGIS SSSSSSVGGR NEEAHHHHHH HGGFFSA--- LLGAAAEEGG GDDDKKLVVD NPPQQQYGVT TSSSSSVGGR NEEAHHHHHH HSDFFTD--- LC-PPGG-KE RFFIIVVVPG RSRRIIIDTK KPPPPPEPKK KIIIIVVPEV VKKSRLLHHC YC-PPAA-KE RYYIIVVVPA RSRRIVVDTK KPPKKKRPAA AVVAAIIPEA AVVTKYYHHC LS-PPTTGHE RFFIIIIIPG RSRRIIIDTK KPPPPPQARR RIIHHIIPDI ILLTRPPHHC LS-PPAAGHE RYYIIIIIPG RSRRIIIDTK KPPPPPKAKK KIIHHIIPEV VFFTRPPHHC LS-PPTTGHE RYYIIIIIPG RSRRIVVDVK K--PPPKAKK KIIHHIIPEV VFFTRPPHHC LC-PPAAPHE RYYVVVVVPG RSRRILLDTK KPPPPPKPFF FLLAAVVPEL LAATRPPHHC LC-PPAAPHE RYYVVVVVPD RSHHILLDTK KPPPPPQPKK KVVVVVVPNL LAATRPPHHC LC-PPAAPHE RYYIIVVVPG RSRRIVVDTK KPPPPPEPRR RIIVVVVPEL LHHTRPPHHC -----FFGDS NKKIILLLPG MSRRIVVDVG GSSPPPAPKK KLLHHVVASI IQQCNTTHHC -----FFGDS DKKIILLLPS ISRRIVVDVG GSSPPPAPKK KLLHHVVPNI IHHCNLLHHC -----FFGDS TKKMMLLLPC MSRRIVVDVG GSSPPPAPKK KLLHHVVAEI IHHCYVVHHC -----YYGDA TKKVVLLLPA ISRRIVVDVG GTTPPPAPKK KLLHHVVPKI IHHCFFFHHC -----FFGDS TKKVVLLLPS ISRRIVVDVG GSSPPPAPKK KLLHHVVPEI IHHCFLLHHC ---------- ---------- ---------- ---------- -------PKI IHHCFLLHHC -----FFGDS TKKVVLLLPS ISRRIVVDVG GSSPPPAPKK KLLHHVVPKI IHHCFLLHHC -----FFGDS TKKVVLLLPS ISRRIVVDVG GSSPPPAPKK KLLHHVVPKI IHHCFLLHHC -----FFGDS NKKVVLLLPS ISRRIVVDVG GTTPPPAPKK KLLHHVVAKI IHHCTPPHHC -----FFGDS TKKVVLLLPS ---------- ---------- ---------- ---------- -----FFGDS TKKVVLLLPS ISRRIVVDVG GSSPPPAPKK KLLHHVVPKI IHHCFLLHHC -----HHGDK RFFIILLLPS LGRRVVVDTA ATTPPPTPSS SLLHHVVSEI IAAIFPPHHC -----YYGDV NKKIILLLPC ISRRIVVDVG GTTPPPAPRR RIIHHTTPYV VFFCNLLHHC -----YYGDV NKKIILLLPC ISRRIVVDVG GSSPPPAPRR RIIHHTTPYV VFFCNPPHHC -----HHGDE RFFIIAAAPS VGRRIIIDTK KTTPPPSPSS SLLHHVVPAI IIITYPPHHC -----HHGDQ RFFIIVVVPG VGRRVIIDTK KTTPPPAPSS SLLHHVVPEI ISSTYPPHHC -----HHGDD RYYVVLLLPS IGRRIIIDTK KEEPPPAPSS SLLYYYYPKI IAATYPPHHC -----HHGDD RYYVVLLLPS IGRRIIIDTK KEEPPPAPSS SLLYYYYPKI IAATFPPHHC -----HHGDS RFFIILLLPS LGRRVVVDTL LKKPPPAPAA ALLHHVVAEI IAATFPPHHC -----HHDKK SHHIIVVVPC NDRRIIINVE ENN---KIYY YLLEETTPSL LHHNFPPHHC -----HHDKK SHHIIVVVPC NDRRIIINVE ENN---EIYY YLLQQTTPSL LHHNFPPHHC ---------- ---VVPPPRK SGVVEVVFVG GGG------- ---------- ---------- HFVPPGGGKT DRRVVLLLPC NDRRIIIDTG GTTPPPAPKK KLLAAVVG-V VLLAAPPHHC YYVDDSSSKK DRRVVLLLPS NDFFILLDVV VTTPPPKPEE EIIVVTTG-V VLLHAPPHHC -------GKG PQQLLQQQLS DKRRLTTTSL LYYAAADKQQ QFFYY----L LIILISSHDY ---------D RFFWWTTTGG DNRRIFFDVH HSSPPPNPKK KLLHHTTT-V VKKGGPPHFA ---------D RYYWWAAAGG DSKKIFFDVH HSSPPPRPVV VLLSSTTD-V VEEGGPPHYA PPDIISSAAG GEE---EEGG GEGGPPPGGG ILLDDSFFFE EPPLLGKDRG DQQ------- PPDIISSAAG GPP---DDGG GEGGPPPGGG IFFDDTFFFE EPPIIGRYRG PQQ------- PPEIISSTTG GAAGGKDDGG GDGGAAAPGG IFFDDTFFFD DVVLLGRDRG PQQ------- PPDIISSTTG GGGGGKDDGG GNGGPPPPGG VFFDDTFFFE EVVLLGRDRG PQQ------- PPEIISSTTG GGGGGEDDGG GDGGPPPPGG IFFDDTFFFE EIILLGRDRG EQQ------- PPGIITTAAG GAA---EEGG GKGGPPPGGG IAADDSFFFE EPPLLGRERG PQQ------- PPDIISSAAG GPP---EEGG GEGGPPPGGG IFFDDNLLLE EVVLLGRDRG DQQ------- PPDVVSSAAG GPP---EEGG GDGGPPPGGG VFFDDSFFFD DPPLLGRERG PQQ------- AASEEVVNNL LDD---LLQQ QNGGKKKGSS FVVDDTFFFE EVVKKGTPGG ASS------- AASEEIISSL LDD---PPQQ QNGGKKKGGG FVVDDTFFFE EVVKKGTPGG EAA------- AASEEIISSL LDD---SSKK KNGGKKKGGG FVVDDTFFFE EVVKKGTPGG AAA------- PPSEEVVSSL LDD---PPEE ENGGKKKGGG FVVDDTFFFE EVVKKGTPGG AAA------- AASEEIISSL LDD---VVKK KNGGKKKGGG FVVDDTFFFE EVVKKGTPGG AAA------- AASEEIISSL LDD---VVKK KNGGKKKGGG FVVDDTFFFE EVVKKGTPGG AAA------- AASEEIISSL LDD---VVKK KNGGKKKGGG FVVDDTFFFE EVVKKGTPGG AAA------- AASEEIISSL LDD---VVKK KNGGKKKGGG FVVDDTFFFE EVVKKGTPGG AAA------- PPTEEIISSL LDD---PPKK KNGGKKKGGG FVVDDTFFFE EVVKKGTPGG SAA------- ---------- ---------- ---------- ---------- ---------- ---------- AASEEIISSL LDD---VVKK KNGGKKKDGG SLLLLRLLLE ECCSSG---- ---------- AASDDIISSL LDD---KKEE ENAAAAAGNN GFFLLEFFFN NVVKKGRRLF PII------- GGCEEIISSI IDD---PPYY YNGGKKKGGG FVVDDTFFFE EVVKKGNEGE AAA------- GGCEEIISSL LDD---PPCC CNGGKKKGGG FVVDDTFFFE EVVKKGNEGE SAA------- AASEEIISSL LDD---KKDD DNAAEEEGNN GFFLLDFFFN NVVKKGRPGH SPP------- AASEEIISSI IDD---KKDD DNAAEEEGNN GFFLLEFFFN NVVKKGRPGH SPP------- AASEEVVSSL LDD---EEEE ENAAKKKGNN GFFLLDFFFN NIIKKNRPGH SPP------- TT-EEVVSSL LDD---EEEE ENAAKKKGNN GLLLLDFFFN NIIKKNRPDI SPP------- AASEEIISSL LDD---KKEE ENAAAAAGNN GFFLLEFFFN NVVKKGRPGH SPP------- AADNNIISSL LEE---AANN NTPPSSSGNN FLLDDTFFFE EPPKKGTDEK TVV------- AADNNIISSL LEE---AADD DSPPSSSGNN FLLDDTFFFE EPPKKGTDGK VVV------- ---------- ---------- ---------- ---------- ---------- ---------- PPNNNIISSM MDD---AAEE ENAAKKKG-- DFFFFNFFFE ELLVVGTGDR KAA------- AANNNIISSM MDD---AAEE EYAAKKKG-- DFFFFDFFFN NCCIIGTGDK KAA------- PPNAAQQDDV VEE---SSLL LVPPVVVLNN GIISSENNNG GLLSSAKSQF EEE------- PPGMMTTGGS SDD---DDDD DGGGRRRTAA LVVNNGEEEY YVVAATYTAD DMMGGAGGAD PPGMMTTGGS SNN---KKDD DGGGRRRTAA LVVTTGEEEY YVVAATHTDG DLLGGKGGAD LYYDFWWWNN LLL--PPNEV SSWWAVVPPN ----IIE--L EEHLKKDD-- RYGGNNIIHF FYYDFWWWNN LLL--PPSGV TTWWTVVPPR ----FFE--L EECLKKEEGG AYGGNNLLHV KYYDFWWWNN LLL--PPRDY SSWWALLPPP ----FFE--P EEDLLLAANN KYGGHHLLHF LYYDFWWWNN LLL--PPRDY TTWWALLPPP ----FFE--P EEDLLLSSNN KYGGHHLLHF KYYDFWWWNN LLL--PPRDY SSWWGLLPPP ----FFE--P EEDLLLSSNN KYGGHHIIHF FYYDGWWWHH LLL--GGYDT TTWWGTTPPD ----VVE--P DDILLLGGAA RYGGRRLLHF LYYDFWWWHH LLL--GGYDT TTWWGTTPPR ----VVE--G DDELLLAAGG KYGGHHLLHV LYYDFWWWHH LLL--GGYDT TTWWGTTPPN ----IIE--P QQILLLNNKK GYGGRRLLHI MYYDFWYYQQ PPP--RRHNV SSWWAAAPPN ----FFKFFA HHVEAA--GG LYGGSSIIFV MYYDFWYYQQ PPP--RRHNI SSWWAAAPPN ----FFKFFA HHVEAA--GG LYGGSSIIHV MYYDFWYYQQ PPP--RRHNV SSWWAAAPPN ----FFRFFA DDVEAA--GG LYGGSSLLHV LYYDFWYYQQ PPP--RRHNV SSWWAAAPPN ----LLRFFA DDVKAA--GG LYGGSSLLYV SYYDFWYYQQ PPP--RRHNV SSWWAAAPPN ----LLRFFA DDVEAA--GG LYGGSSLLYV LYYDFWYYQQ PPP--RRHNV SSWWAAAPPN ----LLRFFA DDVEAA--GG LYGGSSLLYV LYYDFWYYQQ PPP--RRHNV SSWWAAAPPN ----LLRFFA DDVEAA--GG LYGGSSLLYV LYYDFWYYQQ PPP--RRHNV SSWWAAAPPN ----LLRFFA DDVEAA--GG LYGGSSLLYV MYYDFWYYQQ PPP--RRHNV SSWWAAAPPN ----VVQFFA DDVEAA--GG LYGGKKLLHV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --SSAHHSSN ----RRLSSY PPASAA--SS RVAAGGTT-- KRRTHLYYEE NNNYYAAWGL SSQQCCCSSL ----YYTAAM CCLTAA--SS GVHHVVSSCL FYYDFWYYQQ PPP--RRHNV SSWWGAAPPK ----FFAFFE EEVQAA--GG MYGGHHLLNV FYYDFWYYQQ PPP--RRHNV SSWWGAAPPK ----FFAFFE DDVQAA--GG HYGGHHLLNV FYYDFWYYQQ PPP--RRHNT SSWWGAAPPT ----FFTFFQ HHVADD--GG LYGGRRLLTC FYYDFWYYQQ PPP--RRHNT SSWWGAAPPK ----FFLFFQ HHVADD--GG LYGGRRLLHV FYYDFWYYQQ PPP--RRHKT SSWWGAAPPK ----FFSFFQ HHVADD--GG LYGGSSLLHV YYYHFWYYQQ PPP--RRHKT SSWWGAAPPK ----FFSFFQ HHVADD--GG LYGGSSLLHV FYYDYWYYQQ PPP--RRHKT SSWWGAAPPA ----FFRFFQ HHVQDD--GG LYGGRRLLHV FYYDFWYYQQ PPP--RRRNV SSWWGSSPPN ----IIKFFA HHVGEE--GG LYGGNNVVHI FYYDFWYYQQ PPP--RRRNI SSWWGSSPPN ----IIKFFA HHVPEE--GG LYGGNNVVHI ---------- ---------- SSRRGGGPPV ----VVCEEK CCQPEE--PP LVIIKKKKRV CYYDYWYYQQ PPP--HHFNV AAWWGAAPPK ----FFRYYT DDCDDDRRTT QYGGCCLLNF CYYDFWYYQQ PPP--YYFDV SSWWGAAPPN ----WWRWWV DDLEDDMMSS QYGGCCLLNF LLLSNHNNNN GGG----REK SSPPDEEPPI ----AAFSSF LLKKTTGGPP LKPPQQVVAE YYYDIRAALL III--RRKNV TTFFTGGWWS NNYYMMDQQQ DDAEAAMMKK RFGGNNIIVQ YYYDVRAALL PPP--RRKNL TTFFTGGWWN NNYYMMDKKA DDPEAAMMKK HFGGNNVVVT WWWDLRRRRS SSLEEENNNR -----ELLRP LLLPKKKMII MVVVSLKLSS SSIWLLWGGN WWWDLARRRA AALQEEHHHR -----EVVRP LLLPKKKMVV VVVLNTKLSS SSIWLLWGGQ WWWDLRRRRT TTLAQQHHHQ -----EVVRP AAAPRRRYVV VVVVDTTLGS SSIWTTWGGH WWWDLRRRRT TTLANNHHHQ -----EVVRP AAAPRRRYVV VVVVDTTLAS SSIWTTWGGH WWWKLRRRRT TTLANNHHHQ -----EIIRP AAAPKKKYCC VVVVDTTLGA AAIFTTWGGE WWWDLTRRRE EEFDEEHHHQ -----ELLRP AAAPKKKYVV CVVISLKLSS SSIWTTWDDA WWWDLYRRRT TTLAEEYYYQ -----ELLRP AAAPKKKYMM CVVVSLKLAS SSIWLLWGGH WWWDLRRRRA AAVEEEHHHQ -----ELLRP AAAPRRRYVV VVVVSLELAS SSVWLLWGGG WWWDWQHHHT TTM---DDDG ----LEIIRF LLLPAAAQVV CAALSSNQFY YYKNEEE--- WWWDWQHHHT TTM---DDDG ----LEIIRF LLLPAAAQVV CAALSSNQFY YYKNEEG--- WWWDWQHHHT TTL---DDDG ----LEIIRF LLLPAAAQVV CAALSSTQFY YYKNQQG--- WWWDWQRRRT TTL---DDDG ----LEIIRF LLLPAAAQVV CAALSSTQFF FFKNEED--- WWWDWQHHHT TTL---DDDG ----LEIIRF LLLPAAAQVV CAALSSTQFY YYKNEEG--- WWWDWQHHHT TTL---DDDG ----LEIIRF LLLPAAAQVV CAALSSTQFY YYKNEEG--- WWWDWQHHHT TTL---DDDG ----LEIIRF LLLPAAAQVV CAALSSTQFY YYKNEEG--- WWWDWQHHHT TTL---DDDG ----LEIIRF LLLPAAAQVV CAALSSTQFY YYKNEEG--- WWWDWQHHHT TTM---DDDG ----LEIIRF LLLPAAAQVV CAALSSTQFY YYKNEEG--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDDNYIRRRS SSL---DDDQ PPPILCLLRS IIIKIIIQDD VEEVSFSRGS SSDPDDA--- WWWDWTHHHT TTLE--DDDG ----LEIIRF LLLPAAAQVV CAALSSTFFY YYKEKKD--- WWWDWTHHHT TTLK--DDDG ----LEIIRF LLLPAAAQVV CAALSSSFFY YYKEKKD--- IIIQLAGGGT TTLN--TTTG ----LEIIRF LLLPKKKTVV SAALSSNIFF FFKTQQD--- YYYSWPGGGT TTLD--KKKG ----LEIIRF LLLPKKKTVV SAALTSNIFF FFKTQQD--- YYYSWPGGGL LLLE--TTTG ----LEIIRF LLLPKKKTVV SAALSSNIFF FFKNSSD--- YYYSWPGGGL LLLP--TTTG ----LEIIRF LLLPKKKTVV SAALSSNIFF FFKNSSD--- YYYDWPGGGT TTLS--TTTG ----LEVVRF LLLPKKKTVV CAALTSNVFF FFKTAAD--- FFFEWDKKKT TTLQPPLLLG ----LEVVRF LLLPSSSHVV CAALGSGFIH HHPVEEE--- FFFEWDKKKT TTLMPPRRRG ----LEVVRF LLLPSSSHVV CAALGSAFIH HHPDEEK--- YYY------- ---------- ---------- ---------- ---------- ---------- YYYRWQRRRT TTLD--DDDG ----LEIIRF LLLPEEEQVV CAAFXXXXXX XX-------- YYYKWSQQQT TTLS--DDDG ----LEIIRF LLLPKKKEVV CAALNAKFFK KKKKSSD--- VVVL------ ---------- ---------- ---------- ---------- ---------- WWWDLHRRRV VVVGAAPPP- ----LEIIRF PPPSAAAYSS TAALTSQWIY YYEDDDA--- WWWDLHKKKV VVVGAAPPP- ----LEIIRC AAAEHHHYTT TAALTSQWIY YYEDGGE--- NAAAAEIEEE IIPEENNLPE PPFFKAVVPP PLVVTIISSS LDDFYYLGIE EVRNFVVLTK QAAAAEIDDD IIEEEPPLPP DDFFKMVVPP PLVVTIISSS LDDFYYVGLE ELRNHRRLAK HVVVVKATTT IIPTTEELPP GGFFGAVVPP PLVVTILSSS LDDFYYVGTE EMRDHVVLAR HAAAAEATTT IIPPPKKLPP GGFFGAVVPP PLVVTILSSS MDDFYYVGTE EMRDRKKLAH EAAAAKITTT IIDDDDDLPD GGFFGACCPP PLVVTILSSS LDDYYYVGLE EMHDMVVLTE AVVVVRIEEE IIPDDQQLPP GGFFKAVVPP PLVVTILSSS MDDFYYVGTD DLLDFKKLTR HLLLLKIDDD IIPSSQQLPP PPFFKAVVPP PLVVTILSSS VDDFYYVGTE ELHDFRRLTQ GIIIIRIEEE IIPEEQQLPP DDFFGAVVPP PLVVTILSSS LDDFYYVGTE ELRDFRRHTR ------TWWW SSVQQSSKKV MMLLPEMMPG GLIITILSSS LDDFYYFLHD DIRNQRRLTF ------TWWW SSVQQSSKKV MMLLPEMMPG GLIITILSSS LDDFYYFLHD DIRNKRRLTF ------TWWW SSVQQPPKKV MMLLPEMMPG GLIITILSSS LDDFYYFLHD DLRDQRRLTF ------TWWW SSAQQPPKKV MMLLPEMMPG GLIITILSSS LDDFYYFLHD DIRDQRRLTF ------TWWW SSVQQPPKKV LLLLPEMMPG GLIITILSSS LDDFYYFLHD DLRDQRRLTF ------TWWW SSVQQPPKKV LLLLPEMMPG GLIITILSSS LDDFYYFLHD DLRDQRRL-- ------TWWW SSVQQPPKKV LLLLPEMMPG GLIIT----- ---------- ---------- ------TWWW SSVQQPPKKV LLLLPEMMPG GLIITILSSS LDDFYYFLHD DLRDQRRLTF ------TWWW SSVEEPPKKV MMLLPEMMPG GLIITILSSS LDDFYYFLHD DMRDKRRLVF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------AVVV VVLDDYYAVV GGVVVSLLSN NEFFPAIFFF FSDLIIF--- ---------- ------KWWW AAAKKSSKKV AALLPEMMPG GLIITIISSS LDDFYYFLHD DIRDRKKLVF ------KWWW AAAQQSSKKV PPMMPEMMPG GLIITIISSS LDDFYYFLHD DIRDRKKLVF ------SWWW SSHPPPPLKV IILLPEMMPG GLIITFISSS LDDFYYFLHD DIRDKVVLTW ------SWWW NNHSSPPLKV FFLLPEMMPG GLIITFISSS LDDFYYFLHD DIRDKKKLTW ------TWWW SSYSSPPLKV IILLPEMMPG GLIITFISSS LDDFYYFLHD DIRDKVVLTW ------TWWW SSHSSPPLKV IILLPEMMPG GLIITFISSS LDDFYYFLHD DIRDKVVLTW ------SWWW SSHSSPPLKV IILLPEMMPG GLIITFISSS LDDYYYLLHD DIRDAVVLAW ------THHH AAAFFSSKKV AALLPEMMPA ALIITIISSS MDDFYYVLHD DIRDLKKLNY ------VQQQ TTATTSSKKV AALLPDMMPA ALIITIISSS MDDFYYVLHD DIRDKKKLNF ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------QG EEIIEMMMGG GMMMTIISSS LDDYYYFRHD DVRDARRLTF ------EAAA KKKPPLLVDT VVAAEDMMGG GMIISIISSS LDDFYYVRHD DVRDEKKLTF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---EEAAKAV GGNNPADDIP PLPPVIIAAA ADDTWWIMDK KTRDHFFQIV ---------- ---EEAAKAV GGEEPAKKVP PLPPVIISSS NDDRWWVMDK KTRDHRRQVT GFFFHHRAPP ---------- ------AHHK KKLLTTTPLE ESSSSDDGGR VYYYYVVNLY GYYYHHREPP ---------- ------SAAE EEAATTTPIS SSSSSDDGGR VYYYYIINLY GAAARRRAPP ---------- ------NRRT TTFFAAAPVE ESSSSDDGGR VYYYYWWNLY GAAARRRTPP ---------- ------NKKA AAFFAAAPVE ESSSSDDGGR VYYYYWWNLY GVVVKKKTPP ---------- ------NKKT TTFFGGGPVE ESSSSDDGGK VYYYYWWNLY GVVVSSRAPP GG-------- ------KGGA AALLNNNPVE ESSSSDDGGR VYYYYFFNLY GVVVRRRAPP ---------- ------TAAE EELLNNNPVE ESSSSDDGGR VYYYYFFNLY GVVVRRKAPP ---------- ------AGGP PPLLNNNPVE ESSSSDDGGR VYYYYFFNLY GIIIVVRGVV QQVLE-DQEE LTPEEPKKKR RRIIPPPPIQ QSSSSDDGGK LYYYYAATLY GIIIVVKGVV QQVLE-DQEE LTPEEPKKKR RRVVPPPPIQ QSSSSDDGGK LYYYYVVTLY GIIIVVKGVV QQVLE-DQEE LKPEEPKKKK KKVVPPPPIQ QSSSSDDGGK LYYYYVVTLY GIIIVVKDVV QQVLD-DQEE LDPEEPKKKQ QQVVAAAPIQ QSSSSDDGGK LYYYYVVTLY GIIIVVKGVV QQVLE-DQEE LKPEEPKKKR RRVVAAAPIQ QSSSSDDGGK LYYYYIITLY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GIIIVVKGVV QQVLE-DEEE LKPEEPKKKR RRVVAAAPIQ QSSSSDDGGK LYYYYIITLY GIIIVVKGVV QQVLE-DQEE LKPEEPKKKR RRVVPPPPIQ QSSSSDDGGK IYYYYVVTLY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GIIILLRGVV TTVLE-DKDD LEPDDPKKKK KKVVPPPPIQ QSSSSDDGGK LYYYYVVNLY GIIIQQRGVV TTVLE-DKEE LEPDDPKKKI IIIIPPPPIQ QSSSSDDGGK IYYYYVVSLY GIIIQQKGVV AAAIG-EDGG KTSDDVQQQK KKLLRRRPIQ QTTTTDDGGK LYYYYVVNLF GIIIQQKGVV VVAVK-DDGG ETSDDVQKKK KKLLRRRPIQ QSSSSDDGGK LYYYYVVNLF GLLLQQKGVV KKAVG-EDGG NSFDDVKKKS SSLLRRRPIQ QSSSSDDGGK LYYYYAANLF GLLLQQKGVV KKAVG-EDGG NTFEEVKKKS SSLLRRRPIQ QSSSSDDGGK LYYYYAANLF GLLLQQKGVV VVYVT-EDDD KEYSSVKHHR RRLLRRRPIQ QSSSSDDGGK IYYYYVVNLF GVVVHHTEVV KKVLE-GEKK --IEEAKRRK KKIIEEEPLQ QSSSSDDGGK LYYYYVVTLY GIIIHHSEVV KKVLE-EDHH D-IPPAKRRQ QQIIEEEPLQ QSSSSDDGGK LYYYYVVTLY ---------- ---------- ---------- -------PIQ QSSSSDDGGK LYYYYVVNFY GIIIQQRDRR RRVLN-DPEE LKPEEPKRRR RRLLLLLPLQ QSSSSDDGGR LYYYYVVSLF GIIICCSDNN VVIVKEDKEE LKPPPAKRRR RRLLEEEPLQ QSSSSDDGGK LYYYYVVSLY ---------- ---------- ---------- ---------- ---------- ---------- DVVVNN---- ---------- ---------- --------VS SSSSSDDGGK VYYYYFFSLL GVVVNN---- ---------- ---------- --------VS SSSSSDDGGQ LYYYYYYSLL TWDDNFYEGL WMMA------ PGGIIDKEVV VDE----AHL LGGGGGDDAA DSSYCYYYP- SWNNNFY-GL WMMV------ PGGLLEKEVV VDR----AHL LGGGGGDDAA DSSFCYYYP- TWDDDFYDGV AQQA------ PGGLLADDVV VEDG---YHL LGGGGGDDCC DSSFCYYYPV TWDDDFYDGV VEEV------ GGGLLDKDVV VSDG---YHL LGGGGGDDCC DSSFCYYYPV TWDDEFYGDR AMMV------ EGGLLDKDVV VDAG---YHL LGGGGGDDCC DSSFCYYYPV AVDDPFYEGI WMMA------ PGGFFDPKLL LEKG---HHL LGGGGGDDCC DSSYCYYYP- AWDDEFYDGI WMMV------ PGGFFDPNVV VDE----QHL LGGGGGDDAA DSSYCFFFP- SWDDEFYVGI WIIA------ PGGLLDPGTT TEDG---LHL LGGGGGDDSS DSSYCYYYP- DWDDKFYPDL EGGQDDVVTT VGGLLNPNVV VDKELLLAHY YGGGGGDDCC DIIWI----- AWDDKFYPNL EGGQDDVVTT AGGLLNPNVV VDKELLLAHY YGGGGGDDCC DIIWI----- AWDDKFYPDL EGGQDDVVTT VGGLLNPNVV VDKELLLAHY YGGGGGDDCC DIIWL----- AWDDKFYPDL EGGQDDVVTT VGGLLNPNVV VDKELLLAHY YGGGGGDDCC DIIWL----- AWDDKFYPDL EGGQDDVVTT VGGLLNPNVV VDKELLLAHY YGGGGGDDCC DIIWI----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AWDDKFYPDL EGGQDDVVTT VGGLLNPNVV VDKELLLAHY YGGGGGDDCC DIIWI----- DWDDKFYPDL EGGQDDVVTT VGGLLNPNVV VDKELLLAHY YGGGGGDDCC DIIWL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KWDDKFYPDM EGGQDDVVTT EGGLLNPNVV VDKEGGGVHY YGGGGGDDCC DIIWV----- IWDDKFYPDL EGGQDDVVTT KGGLLNPNVV VDKEDDDVHY YGGGGGDDCC DIIWI----- AWDDKFYPGL KGGQDDVVTT EGGIINPNVV VDAEDDDAHY YGGGGGDDCC DIIWI----- AWDDKFYPKL QGGQDDVVTT EGGIINPNVV VDAEDDDSHY YGGGGGDDCC DIIWI----- AWDDRFYPEL KGGQDDVVTT EGGIINPNVV VDDEEEEAHY YGGGGGDDCC DIIWI----- AWVVVFYPEI KGGQDDGGTT EGGIINPDVV VDDEDDDSHY YGGGGGDDCC DIIWI----- RWDDEFYQDL KGGQDDVVTT EGGIINPNVV VDAEEEESHY YGGGGGDDCC DIIWI----- KWDDDFYPEH SGGQNNIIPP EGKIINRDII IDKIGGGYHY YGGGGGDDCC DIIWI----- KWDDDFYPEN SGGQDDVVPP IGHIINKNII IDKVGGGYHY YGGGGGDDCC DIIWI----- TWDDKFYPNV EGGQDDVVTT EGGVVNKNVV VDKENNNCHF FGGGGGDDSS DIILA----- PWDDKFYPEM AGGQDDIIVV EGGLLNENVV VDGEYYYGH- ---------- ---------- PWDDKFYPKM QGGLDDVVTT VGGLLNEDVV VDNEYYYSHY YGGGGGDDCC DIIWLAAANA ---------- ---------- ---------- ---------- ---------- ---------- NWDD------ KGGQLLKKYY NDGLLVEDVV VDELLLL-HF FSSSSSAALL S--------- NWDD------ KGGQLLKKYY YDGLLKEQII IDAELLL-HF FRRRRRAALL GPPAGDDDGR ------- ------- KRR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LVVQAVV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSSSAQPEAT AVPPPTTTAA RRLGAAMMMS LRRRRAAQLL LLLLLLLPGP RIKAYQEAAW gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ----MAGRRA gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSAIQQVVVL SSSRESRKKK TTTRRRSPGV EEEEISAVKV VVVVPPSQAA WWLLLPPGHA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----AAREF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGLLLGGEPT ---------- ---------- ---------- ---------- --------LL NNSSSQQCGQ ---------- ---------- ---------- ---------- ---------- ---------- PPPLNNNNNR TTTHNPPAAA SSSPPPPPRP LLLLTRVRYT TTIINNVPPP HHAAARRSVH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMMKKRF- ---------- ---------- ---------- ---------- ---------- --MMMKKFVP ---------- --------MA PFDPPTFFFY YYYPSAAMMK PPPPDAAYYY AAACYTTGGG ---------- ---------- KLDPPTFFFY YYYPTAAMMR PPPPDAAYYY AAAAYVVGGG ---------- ---------- SMDPPTFFFH HHHASAAMMQ PPAAEAAYYY LLLLSPPDSS ---------- ---------- TMDPPTFFFH HHHASAAMME PPAANAAYYY LLLLSPPDSS ---------- ---------- TLDPPTFFFY YYYPSAAMME PPVVKAAFFF LLLMSPPDSS ---------- ---------- TWDPPSFFFY YYYPSAAAAK PPPPTAAYYY AAAMDPPEKK ---------- ---------- TWDPPTFFFY YYYPSAAVVK PPAAKAAYYY VVVRNPPMNN ---------- ---------- SWDPPTFFFY YYYPSAAMMQ PPRRRGGYYY AAALDPPGEE ---------- ----MMMATK K-GPPGYYYP PPPTPMMKK- PPRREVVYYY PPPCYRRNGG ---------- ---------- ---------- -------MM- PPRREVVYYY PPPCYRRNGG VVLLLIIPPL G--AHHHSTQ K-GPPGYYYP PPPSPMMKK- PPRREVVYYY PPPCYGGNGG ---------- ---------- ---------- -----MMKK- PPRREIIYYY PPPCYRRNGG ---------- ----MMMATK N-GPPGYYYS SSSTPMMKK- PPRREVVYYY PPPCYRRNGG TTLLLQQVVM IAASTTTATK N-GPPGYYYS SSSTPMMKK- PPRREVVYYY PPPCYRRNGG ---------- ----MMMATK N-GPPGYYYS SSSTPMMKK- ---------- ---------- ---------- ----MMMATK N-GPPGYYYS SSSTPMMKK- PPRREVVYYY PPPCYRRNGG AAQQQPPFFQ QEEDTTTATK D-GPPGYYYP PPPTPMMKK- PPRREVVYYY PPPCYRRNGG TTNNNTTLLC VFFTSSSPTK N-GPPGYYYS SSSTPMMKK- PPRREVVYYY PPPCYRRNGG ---------- ----MMMATK N-GPPGYYYS SSSTPMMKK- PPRREVVYYY PPPCYRRNGG IIMMMEEAAE AAAANNNGKT HTGPPGYYYA AAATPMMEEK PPRRKVVYYY TTTCYNNGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MAK S-GPPGYYYK KKKSPMMKK- PPRREVVYYY PPPCYRRSGG --MMMAAVVG NEEKKKKS-V CCGPPGYYYA AAASPMMSS- PPRRSIIYYY TTTAYAAGGG --MMMGGVVA SEEKVVVNNQ CCGPPGYYYA AAASPMMSS- PPRRTIIYYY TTTAYAAGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LQGPPGYYYA AAATPMMSS- PPSSKIIYYY TTTAYTTGGG ---------- AAAANNNGAA GGGPPGYYYA AAATPMMEEK PPRRKLLYYY TTTCYNNGGG ---------- SPPNCCCGLK G-GPPGYYYA AAASPIIKK- PPRRELLFFF TTTA----AA ---------- P---CCCPLK G-GPPGYYYA AAASPIIKK- PPRRELLFFF TTTA----AA ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MS KCGPPGYYYA AAATPVVRRN PPVVKLLYYY VVVCQPPNDD ---------- ---------- ---------- -----MMRRS PPRRKLLYYY VVVTQPPNDD ---------- ---------- --MPPGLLLI IIIT-LLIIS DDDDFYYFFF NNNWHGGDRR ---------L G--ALLLAMG FRADDETTTC CCCQSPPKKI GGQQEVVYYY WWWTGVVEMM SSMMMHHAAL GLLALLLALA AGADDETTTC CCCASKKKKI GGQQDVVYYY WWWTGAAEVV GIINNNADDA DNKETTYSKV VHKKVYYYYI EEELLHHGWW CCSALLCN-K PPIIEEERFF GVVNNNPDDA DDKPTTYGKI IYKKLYYYYI EEELLHHGWW CCSAYYCN-K PPLLEEERYY S-----PDDA DKGSTTYGKV VHTTVNNNNT EEEFFHHGWW CCSSLLSLGH AALLEEERFF S-----PDDA DKGPTTYGQV VHTTVNNNNK EEEFFHHGWW CCSALLSLGH AAIIEEERYY S-----PDDA DDTEKKFGQV VHQQLNNNNK EEEFFHHGWW CCSALLSLGH AALLEEERYY K-----PDDA DDAPRRYASV VGQQVHHHHA EEELLHHGWW CCSCLLCNPH PPMMEEERYY NGG---PDDC DDQSTTFGQV VGVVTYYYYT EEELLHHGWW CCSMLLCNPH PPVVEEERYY E-----PDDG DDDGTTYAQV VGRRVNNNNA EEELLHHGWW CCAALLCYPH PPVVEEERYY GTTEEEPDDA DDKPQQYSQI IHRRLYYYYL EEELLHHGWW CCSC----GD SSKKSSSRKK GIIEEEPDDA DDKPHHYSQI IHRRLHHHHL EEELLHHGWW CCSC----GD SSKKSSSRKK GIIEEEPDDA DDKPQQYCQI IHRRLNNNNL EEELLHHGWW CCSC----GD SSKKSSSRKK GIIEEEPDDA DDKPQQYCQI IHRRLHHHHL EEELLHHGWW CCSC----GD IIKKAAARKK GTTEEEPDDA DDKPQQYCQI IHRRLNNNNL EEELLHHGWW CCSC----GD SSKKSSSRKK GTTEEEPDDA DDKPQQYCQI IE-------- ---------- ---------- ---------- -TTEEEPDDA DDKPQQYCQI IHRRLNNNNL EEELLHHGWW CCSC----GD SSKKSSSRKK GTTEEEPDDA DDKPQQYCQI IHRRLNNNNL EEELLHHGWW CCSC----GD SSKKSSSRKK GTTEEEPDDA DDKPQQYSQI IHRRLYYYYL EEELLHHGWW CCSC----GD SSKKSSSRKK GTTEEEPDDA DDKPQQYCQI IHRRLNNNNL EEELLHHGWW CCSC----GD SSKKSSSRKK GTTEEEPDDA DDKPQQYCQI IHRRLNNNNL EEELLHHGWW CCSC----GD SSKKSSSRKK GIINNNLDDA DDSPTTYSQI IHRRLHHHHI KKKLLHHGWW CCSC----GD PPAAKKKRFF ---------- ---------- -----NNNNT EEELLHHGWW CCSC----GD AAKKVVVRKK GIINNNPDDA DDKPSSYSQI IHRRLNNNNV EEELLHHGWW CCSC----GD SSKKVVVRKK GIIEEEPDDA DDSPTTYSKI IHRRLYYYYV EEELLHHGWW CCSC----GD PPAAEEERFF GIIEEEPDDA DDNPTTYSKI IHRRLYYYYV EEELLHHGWW CCSC----GD PPAAQQQRFF ---------- ---------- -----FFFFV EEELLHHGWW CCSC----GD AAAADDDRYY GIIDDDPDDA DDSPSSYSSI IHRRLFFFFV EEELLHHGWW CCSC----GD AAVVDDDRYY GIINNNPDDG DDNPTTYSQI IHRRLHHHHV EEELLHHGWW CCSC----GD PPAASSSRFF AAADDDPDDF DNEDTTFCQI ISRRVHHHHI EEEVVHHGWW CCSC----DK PPEEKKKRHH ARRDDDPDDF NNEETTFCQI ISRRVNNNNI EEEVVHHGWW CCSC----DK PPEEKKKRHH ---------- ---------- ---------- ---------- ---------- ---------- DEEEEEGDDA DDAPTTYCQI IHRRTSSSSK EEELLHHGWW CCSCHHF-GK EEPPTTTRRR DEEPPPGDDS DDEPTTYCQV VHRRTRRRRK EEELLHHGWW CCSCYYYESK TTPPKKKRRR RQQYYYITTK RVQFLLGGSL LKDDGVVVVL KKKEELLQPP RRLK----GK RRQQGGGGQQ MGGDDDQDDV DRGATTRGQI INSSVGGGG- EEEAAHHGFF ---------- ----DDDRFF VGGDDDQDDV DNKPQQYGKV VNTTLGGGG- EEEAAHHDFF ---------- ----DDDRYY GRRRSSSRII DPPEKIKVII IEPEVKKKVV SSRRLLLHTT VPPIIAGEE- EEGGGEGGGH ARRRSSSRIV DPPRAAKIVV VEPEAVVVRR TTKKYYYHTT VPPIIAGPP- DDGGGEGGGH GRRRSSSRVI DPPQRHKIII IEPDILLLKK TSRRPPPHTT VPPIVTGAAK DDGGGDGGGC GRRRSSSRII DPPKKHKIII IEPEVFFFKK TSRRPPPHTT IPPIVTGGGK DDGGGNGGGC GRRRSSSRIV D--KKHKIII IEPEVFFFKK TSRRPPPHTT IPPIVTGGGE DDGGGDGGGC GRRRSSSRIL DPPKFAKVII IEPELAAARR TSRRPPPHTT VPPIVAGAA- EEGGGKGGGA DRRRSSSHIL DPPQKVKVII IDPNLAAARR TARRPPPHTT VPPIIAGPP- EEGGGEGGGH GRRRSSSRIV DPPERVKVII IEPELHHHRR TSRRPPPHTT IPPVVAGPP- EEGGGDGGGH GMMMSSSRVV DSSAKHKVII IEASIQQQKK CSNNTTTHTT SAAEMNLDD- LLQQQNGGSG SIIISSSRVV DSSAKHKVII IEPNIHHHKK CGNNLLLHTT SAAEMSLDD- PPQQQNGGGG CMMMSSSRVV DSSAKHKVII IEAEIHHHKK CGYYVVVHTT SAAEMSLDD- SSKKKNGGGG AIIISSSRVV DTTAKHKVII IEPKIHHHKK CGFFFFFHTT SPPEMSLDD- PPEEENGGGG SIIISSSRVV DSSAKHKVII IEPEIHHHKK CAFFLLLHTT SAAEMSLDD- VVKKKNGGGG ---------- ---------- --PKIHHHKK CAFFLLLHTT SAAEMSLDD- VVKKKNGGGG SIIISSSRVV DSSAKHKVII IEPKIHHHKK CAFFLLLHTT SAAEMSLDD- VVKKKNGGGG SIIISSSRVV DSSAKHKVII IEPKIHHHKK CAFFLLLHTT SAAEMSLDD- VVKKKNGGGG SIIISSSRVV DTTAKHKVII IEAKIHHHKK CGTTPPPHTT SPPEMSLDD- PPKKKNGGGG S--------- ---------- ---------- ---------- ---------- ---------- SIIISSSRVV DSSAKHKVII IEPKIHHHKK CAFFLLLHTT SAAEMSLDD- VVKKKNGGGP SLLLSGGRVV DTTTSHKVVV VESEIAAANN IGFFPPPHTT SAADMSLDD- KKEEENAAND CIIISSSRVV DTTARHKTVV VEPYVFFFKK CANNLLLHTT SGGEMSIDD- PPYYYNGGGG CIIISSSRVV DSSARHKTVV VEPYVFFFKK CANNPPPHTT SGGEMSLDD- PPCCCNGGGG SVVVSGGRVI DTTSSHKVVV VDPAIIIIKK TAYYPPPHTT SAAEMSLDD- KKDDDNAAND GVVVSGGRVI DTTASHKVVV VEPEISSSKK TAYYPPPHTT SAAEMSIDD- KKDDDNAAND SIIISGGRAI DEEASYKYVV VDPKIAAAKK TAYYPPPHTT AAAELSLDD- EEEEENAAND SIIISGGRAI DEEASYKYVV VDPKIAAAKK TAFFPPPHTT ATTELSLDD- EEEEENAAND SLLLSGGRVV DKKAAHKVVV VEAEIAAAKK TGFFPPPHTT SAAEMSLDD- KKEEENAAND CNNNSDDRII NNNKYEHTII IEPSLHHHLL NSFFPPPHTT SAANMSLEE- AANNNTPPNG CNNNSDDRVI NNNEYQHTII IEPSLHHHLL NSFFPPPHTT SAANMSLEE- AADDDSPPNG KSSSSGGVKV FGG------- ---------- ---------- ---------- ---------- CNNNSDDRVI DTTAKAKVII IEG-VLLLGG ATAAPPPHTT TPPNMSMDD- AAEEENAA-D SNNNSDDFIL DTTKEVKTII IDG-VLLLSS HTAAPPPHTT TAANMSMDD- AAEEEYAA-D SDDDGKKRVT TYYDQYP--- ----LIIIFF LAIISSSHTT APPAKDVEE- SSLLLVPPNK GDDDTNNRIF DSSNKHKTII IDT-VKKKSS GVGGPPPHTT FPPMIGSDD- DDDDDGGGAD GDDDTSSKVF DSSRVSKTII ITD-VEEESS GVGGPPPHTT LPPMIGSNN- KKDDDGGGAN YSFEEPPLLL GKEIIDDRRR RQQ------- -------AYF FWWWL-EVVL LLSEEWWAAN DTFEEPPIII GREVVYYRRR RQQ------- -------AYF FWWWL-GVVM MMSEEWWTTR ETFDDVVLLL GREIIDDRRR RQQ------- -------HYF FWWWL-DYYM MMSEEWWAAP ETFEEVVLLL GREIIDDRRR RQQ------- -------HYF FWWWL-DYYM MMSEEWWAAP ETFEEIILLL GREMMDDRRR RQQ------- -------HYF FWWWL-DYYM MMSEEWWGGP QSFEEPPLLL GREVVEERRR RQQ------- -------AYG GWWWL-DTTL LLSEEWWGGD DNLEEVVLLL GREIIDDRRR RQQ------- -------HYF FWWWL-DTTL LLSEEWWGGR ESFDDPPLLL GREVVEERRR RQQ------- -------AYF FWWWL-DTTM MMSEEWWGGN ETFEEVVKKK GTEKKPPGGG GSS------- -------GYF FWWYP-NVVM MMTEEWWAAN ETFEEVVKKK GTEKKPPGGG GAA------- -------GYF FWWYP-NIIM MMTEEWWAAN ETFEEVVKKK GTEQQPPGGG GAA------- -------GYF FWWYP-NVVM MMTEEWWAAN KTFEEVVKKK GTEQQPPGGG GAA------- -------GYF FWWYP-NVVM MMTEEWWAAN ETFEEVVKKK GTERRPPGGG GAA------- -------GYF FWWYP-NVVM MMTEEWWAAN ETFEEVVKKK GTERRPPGGG GAA------- -------GYF FWWYP-NVVM MMTEEWWAAN ETFEEVVKKK GTERRPPGGG GAA------- -------GYF FWWYP-NVVM MMTEEWWAAN ETFEEVVKKK GTERRPPGGG GAA------- -------GYF FWWYP-NVVM MMTEEWWAAN ETFEEVVKKK GTERRPPGGG GAA------- -------GYF FWWYP-NVVM MMTEEWWAAN ---------- ---------- ---------- ---------- ---------- ---------- -RLEECCSSS G--------- ---------- ---------- ---------- --AIISSAAN SEFNNVVKKK GRSNNRRLLL LII------- -------ERH HLLYNYGLLF FFWIIQQCCL ETFEEVVKKK GNEAAEEGGG GAA------- -------GYF FWWYP-NVVM MMTEEWWGGK ETFEEVVKKK GNEVVEEGGG GAA------- -------GYF FWWYP-NVVM MMTEEWWGGK SDFNNVVKKK GREKKPPGGG GPP------- -------GYF FWWYP-NTTM MMTSSWWGGT SEFNNVVKKK GREKKPPGGG GPP------- -------GYF FWWYP-NTTM MMTSSWWGGK SDFNNIIKKK NREKKPPGGG GPP------- -------GYF FWWYP-KTTM MMTSSWWGGK SDFNNIIKKK NREKKPPDDD DPP------- -------GYF FWWYP-KTTM MMTSSWWGGK SEFNNVVKKK GREKKPPGGG GPP------- -------GYY YWWYP-KTTM MMSSSWWGGA KTFEEPPKKK GTPAADDEEE EVV------- -------NYF FWWYP-NVVM MMTEEWWGGN KTFEEPPKKK GTPAADDGGG GVV------- -------NYF FWWYP-NIIM MMTEEWWGGN ---------- ---------- ---------- ---------- ---------- --ILLRRGGV KNFEELLVVV GTSRRGGDDD DAA------- -------GYY YWWYP-NVVM MMSEEWWGGK SDFNNCCIII GTTKKGGDDD DAA------- -------GYF FWWYP-DVVM MMSEEWWGGN HENGGLLSSS AKEAASSQQQ QEE------- -------QLN NHHNG-EKKS SSDRRPPDDI DGEYYVVAAA TYMPPTTAAA AMMGAVVGGD DAVVAGGGYI IRRAI-NVVM MMSSSFFTTS AGEYYVVAAA THIPPTTDDD DLLGAIIGG- -KYYAGGDYV VRRAP-NLLL LLSSSFFTTN --TDDG---- LLLKLLEHLK D-----RYYY YGGNRIIHHH LLKKRILTGG NMA------- --CEEG---- FFFSLLECLK EGGGGGAYYY YGGNKLLHHH LLKKRLIDGG HMV------- --QNNG---- IIIVPPEDLL ANNNNNKYYY YGGHRLLHHH LLAARVIDGG HMA------- --QNNG---- IIIVPPEDLL SNNNNNKYYY YGGHRLLHHH LLAARVIDGG HMA------- --QNNG---- IIIVPPEDLL SNNNNNKYYY YGGHKIIHHH LLDDRVIDGG HMA------- --MDDG---- LLLVPPDILL GAAAAARYYY YGGRRLLHHH LLRRRLIDGG HLV------- --MSSG---- VVVLGGDELL AGGGGGKYYY YGGHRLLHHH LLRRRLLDGG YMA------- --MGGG---- LLLDPPQILL NKKKKKGYYY YGGRRLLHHH LLRRRLLDGG HMV------- --VDDGFFFF NNNPAAHVEA -GGGGGLYYY YGGSRIIFFF WWRRHILQTT DLI-----LL --VDDGFFFF NNNPAAHVEA -GGGGGLYYY YGGSHIIHHH WWRRHILQKK DLI-----LL --VDDGFFFF NNNPAADVEA -GGGGGLYYY YGGSHLLHHH WWRRHILTQQ DLI-----LL --VDDGFFFF NNNPAADVKA -GGGGGLYYY YGGSHLLYYY WWRRRVLPQQ DLI-----LL --VDDGFFFF NNNPAADVEA -GGGGGLYYY YGGSHLLYYY WWHHHVLSKK DLI-----LL --VDDGFFFF NNNPAADVEA -GGGGGLYYY YGGSHLLYYY WWRRHVLSKK DLI-----LL --VDDGFFFF NNNPAADVEA -GGGGGLYYY YGGSHLLYYY WWRRHVLSKK DLI-----LL --VDDGFFFF NNNPAADVEA -GGGGGLYYY YGGSHLLYYY WWRRHVLSKK DLI-----LL --VNNGFFFF NNNPAADVEA -GGGGGLYYY YGGKHLLHHH WWRRHVLLPP DHI-----LL ---------- ---------- ---------- ---------- ---------- ---------- --LTTGSSSS RRRDYYPASA -SSSSSRVVV VAAGITT--- ---------- ---------- --FTTGAAAA EEELMMCLTA -SSSSSGVVV VHHVISSCCC YYMMRDLPQQ DAGNPPPILL --ALLGFFFF KKKMEEEVQA -GGGGGMYYY YGGHSLLNNN WWEEHIIDGG DLI-----LL --ALLGFFFF KKKMEEDVQA -GGGGGHYYY YGGHSLLNNN WWEEHVIDGG DLI-----LL --AKKGFFFF DDDLQQHVAD -GGGGGLYYY YGGRHLLTTT LLRRGRLDGG TLL-----LL --AQQGFFFF NNNLQQHVAD -GGGGGLYYY YGGRHLLHHH WWGGGKLDGG KLL-----LL --AKKGFFFF DDDLQQHVAD -GGGGGLYYY YGGSHLLHHH WWGGGKIDGG TLL-----LL --AKKGFFFF NNNLQQHVAD -GGGGGLYYY YGGSHLLHHH WWGGGKIDGG TLL-----LL --ATTGFFFF DDDLQQHVQD -GGGGGLYYY YGGRHLLHHH WWGGGKLDGG TLL-----LL --HKKGFFFF NNNPAAHVGE -GGGGGLYYY YGGNSVVHHH WWSSKLIDPP LAL-----LL --HKKGFFFF NNNPAAHVPE -GGGGGLYYY YGGNSVVHHH WWTTKLIDPP RAL-----LL --TRRDEEEE EEELKKCQPE -PPPPPLVVV VIIKCKKRRR ---------- ---------- --LRRGYYYY HHHPTTDCDD RTTTTTQYYY YGGCRLLNNN WWEERFIDGG DLT-----LL --KRRGWWWW KKKNVVDLED MSSSSSQYYY YGGCRLLNNN WWTTQYIDGG DIT-----LL --MEESSSSS EEESFFLKKT GPPPPPLKKK KPPQHVVAAA ---------- ---------- YYMFFGQQQQ MMMLQQDAEA MKKKKKRFFF FGGNTIIVVV LLTTRKFNPP P-------LL YYMFFGKKKK MMMLAADPEA MKKKKKHFFF FGGNTVVVVV LLTTKKFDPP P-------LL ELPLLHHDTT TKKGIILSSS SWWWWF--EG KKWWNNNAAE KKVIIAEPPL EGG---NNPP EVPLLHHDTT TKKGVVTSSS SWWWWF--EG KKWWQQQAAE RRVIIAQPPF EGG---PPPP EVPAAHHDVV VRRGVVTEGS SWWWWW--EG KKFFHHHVVK KKTAIAEPPA TAADDDEEPP EVPAAHHDVV VRRGVVTEAS SWWWWW--EG KKFFHHHAAE KKTAIPEPPA PKKEEEKKPP EIPAAHHDSS SKKGCCTQGA AFFWWWKKDG TTFFEEEAAK KKTIIPVPPA DAADDDDDPP ELPAAHHDTT TKKGVVLSSS SWWWWY--DD KKWWAAAVVR KKVIIAEAAA DPPDDDQQPP ELPAAHHDTT TKKGMMLSAS SWWWWY--DG SSWWHHHLLK KKVIIAEPPA SEEDDDQQPP ELPAAHHDAA ARRGVVLSAS SWWWWH--QG SSWWGGGIIR KKVIIAEPPA EPPDDDQQPP EIFLLHHDSS SAAGVVSRFY YNNEEG---- ---------- ---TSEKVVI QVVPPPSSKK EIFLLHHDDD DAAGVVSRFY YNNGGG---- ---------- ---TSEKVVI QVVPPPSSKK EIFLLHHNDD DAAGVVSRFY YNNGGG---- ---------- ---TSEKVVI QVVPPPPPKK EIFLLHHNDD DAAGVVSRFF FNNDDG---- ---------- ---TSQKVVI QVVPPPPPKK EIFLLHHNDD DAAGVVSRFY YNNGGG---- ---------- ---TSEKVVI QVVPPPPPKK EIFLLHHNDD DAAGVVSRFY YNNGGG---- ---------- ---TSEKVVI QVVPPPPPKK EIFLLHHNDD DAAGVVSRFY YNNGGG---- ---------- ---TSEKVVI QVVPPPPPKK EIFLLHHNDD DAAGVVSRFY YNNGGG---- ---------- ---TSEKVVI QVVPPPPPKK EIFLLHHDAA AAAGVVSRFY YNNGGG---- ---------- ---TSEKVVI EVVPPPPPKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CLSIIHHWNN NIIDDDFGGS SPPAAY---- ---------- ---AVKRKKL DLLYYYYYVV EIFLLHHDDD DAAGVVSRFY YEEDDG---- ---------- ---KAEKVVI KVVPPPSSKK EIFLLHHNDD DAAGVVSRFY YEEDDG---- ---------- ---KAEKVVI QVVPPPSSKK EIFLLHHDAA AKKGVVSRFF FTTDDG---- ---------- ---SSELAAI PVVKKKPPKK EIFLLHHDAA AKKGVVSRFF FTTDDG---- ---------- ---SNEIVVI SVVEEEPPKK EIFLLHHDSS SKKGVVSRFF FNNDDD---- ---------- ---TSEIVVI SVVKKKPPKK EIFLLHHDSS SKKGVVSRFF FNNDDE---- ---------- ---TSEVVVI SVVKKKPPKK EVFLLHHDSS SKKGVVSRFF FTTDDG---- ---------- ---SSEVAAI SIIKKKPPKK EVFLLHHETT TSSAVVSRIH HVVEEN---- ---------- TT-TATLVVA FIIPPPSSKK EVFLLHHETT TSSAVVSRIH HDDKKN---- ---------- KK-VTSLVVA TIIPPPSSKK ---------- ---------- ---------- ---------- ---------- ---------- EIFLLHHNRR REEGVVXXXX X--------- ---------- ---------- --------QQ EIFLLHHNKK KKKGVVAHFK KKKDDS---- ---------- EEFEKVIDDI PGGKKKLLDD ---------- ---------- ---------- ---------- ---------- ---------- EIFPPWWGNN NAAASSSLIY YDDAAG---- ---------- ---------- EWWQQQAAAA EICAAWWGAA AHHCTTSLIY YDDEEG---- ---------- ---------- EWWQQQAAAA EEEIIPFAVV VPPLVVDDDI DDISSDDKKF FLYLWWGGGI GEVRYYINNP FKKVVLTTGG PPPVVDFMVV VPPLVVDDDI DDISSDDRRF FLYLWWGGGL GELRYYINNP HQQRRLAAGG PPPLLGFAVV VPPLVVDDDI DDLSSDDRRF FLYCWWGGGT GEMRYYVDDP HNNVVLAAGG PPPLLGFAVV VPPLVVDDDI DDLSSDDRRF FLYCWWGGGT GEMRYYVDDP RKKKKLAAGG DDDLLGFACC CPPLVVDDDI DDLSSDDKKY YLYCWWGGGL GEMHYYVDDP MNNVVLTTGG PPPVVGFAVV VPPLVVDDDI DDLSSDDRRF FLYCWWGGGT GDLLYYVDDP FEEKKLTTGG PPPIIPFAVV VPPLVVDDDI NNLSSDDRRF FLYCWWGGGT GELHYYVDDP FNNRRLTTGG PPPLLDFAVV VPPLVVDDDI NNLSSDDRRF FLYCWWGGGT GELRYYVDDP FNNRRHTTGG VVVKKMLEMM MPGLIIDDDI LLLSSDDRRF FLYNWWLLLH GDIRYYINNP QKKRRLTTGG VVVKKMLEMM MPGLIIDDDI LLLSSDDRRF FLYNWWLLLH GDIRYYINNP KKKRRLTTGG VVVKKMLEMM MPGLIIDDDI LLLSSDDRRF FLYNWWLLLH GDLRYYIDDP QRRRRLTTGG VVVKKMLEMM MPGLIIDDDI LLLSSDDHHF FLYNWWLLLH GDIRYYVDDP QRRRRLTTGG VVVKKLLEMM MPGLIIDDDI LLLSSDDRRF FLYNWWLLLH GDLRYYIDDP QRRRRLTTGG VVVKKLLEMM MPGLIIDDDI LLLSSDDRRF FLYNWWLLLH GDLRYYIDDP QRRRRL---- VVVKKLLEMM MPGLII---- ---------- ---------- ---------- ---------- VVVKKLLEMM MPGLIIDDDI LLLSSDDRRF FLYNWWLLLH GDLRYYIDDP QRRRRLTTGG VVVKKMLEMM MPGLIIDDDI LLLSSDDRRF FLYNWWLLLH GDMRYYIDDP KRRRRLVVGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVAAGVSLL LSNEFFPPPA WWIFFDDLLL LIIS------ ---------- ---------- VVVEEALEMM MPGLIIDDDI LLISSDDRRF FLYNWWLLLH GDIRYYIDDP RNNKKLVVGG VVVEEPMEMM MPGLIIDDDI LLISSDDRRF FLYNWWLLLH GDIRYYIDDT RNNKKLVVGG VVVQQILEMM MPGLIIDDDF LLISSDDRRF FLYNWWLLLH GDIRYYIDDL KNNVVLTTGG VVVQQFLEMM MPGLIIDDDF LLISSDDRRF FLYNWWLLLH GDIRYYIDDV KNNKKLTTGG VVVEEILEMM MPGLIIDDDF LLISSDDRRF FLYNWWLLLH GDIRYYIDDP KNNVVLTTGG VVVEEILEMM MPGLIIDDDF LLISSDDRRF FIYNWWLLLH GDIRYYIDDP KNNVVLTTGG VVVRRILEMM MPGLIIDDDF VVISSDDRRY YLYNWWLLLH GDIRYYIDDP AKKVVLAAGG VVVSSALEMM MPALIIDDDI LLISSDDRRF FLYCWWLLLH GDIRYYIDDP LKKKKLNNSS VVVEEALDMM MPALIIDDDI LLISSDDRRF FLYCWWLLLH GDIRYYIDDP KNNKKLNNSS ---------- ---------- ---------- ---------- ---------- ---------- GGGEEEIMMM MGGMMMDDDI LLISSDDRRY YLYNWWRRRH GDVRYYIDDR ANNRRLTTGG TTTGGVADMM MGGMIIDDDI IIISSDDRRF FLYCWWRRRH GDVRYYIDDP ENNKKLTTGG ---------- ---------- ---------- ---------- ---------- ---------- VVVAAGNADD DIPLPPDDDI SSIAADDQQT TLWSFFMMMD GKTRFFIDDP HKKFFQIIYY VVVAAGEAKK KVPLPPDDDI SSISSDDSSR RLWTFFMMMD GKTRFFIDDP HHHRRQVVYY KVVVVVKKLL GGGIFRRRAA HPP------- ---ALTGQQM MMLLEISSRD DRVVTTNSLL RVVVVVKKII GGGLYRRREE HPP------- ---SATGQQM MMIISVSSRD DRIITTNSLL SVVVVVRRII GGGIARRRAA HPP------- ---NFAGQQM MMVVEISSRD DRWWTTNSLL SVVVVVHHII GGGIARRRTT HPP------- ---NFAAQQM MMVVEISSRD DRWWTTNSLL KVVVVVEEII GGGIVKKKTT HPP------- ---NFGYQQM MMVVEISSRD DKWWTTNSLL KVVVVVRRII GGGIVRRRAA HPP------- ---KLNGQQM MMVVEISSRD DRFFTTNSLL KVVVVVQQII GGGIVRRRAA HPP------- ---TLNGQQM MMVVEISSRD DRFFTTNSLL SVVVVVRRLL GGGIVKKKAA HPP------- ---ALNGQQM MMVVEVSSRD DRFFSSNSLL QIIIIIFFLL GGGSIRRRGG SVVVLEDECQ EELKIPGQQM MMIIQLSSLD DKAATTTSLL QIIIIIFFLL GGGSIKKKGG SVVVLEDECQ EELKVPGQQM MMIIQLSSLD DKVVTTTSLL QLLLLLFFLL GGGSIKKKGG PVVVLEDESQ EELKVPGQQM MMIIQLSSLD DKVVTTTSLL QLLLLLFFLL GGGSIKKKDD PVVVLDDESQ EELKVAGQQM MMIIQLSSLD DKVVTTTSLL QLLLLLFFLL GGGSIKKKGG PVVVLEDESQ EELKVAGQQM MMIIQLSSLD DKIITTTSLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QLLLLLFFLL GGGSIKKKGG PVVVLEDESQ EELKVAGQQM MMIIQLSSLD DKIITTTSLL QIIIIIFFLL GGGSIKKKGG PVVVLEDESQ EELKVPGQQM MMIIQLSSLD DKVVTTTSLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QIIIIIFFLL GGGSIRRRGG PVVVLEDDCQ DDVKVPGQQM MMIIQLSSLD DKVVTTNSLL QIIIIIFFLL GGGSIRRRGG PVVVLEDECQ DDVKIPGQQM MMIIQLSSLD DKVVTTSSLL QLLLLLWWVV GGGLIKKKGG PVVAIGEGWQ DDPQLRGQQM MMIIQLTTLD DKVVTTNSLL QVVVVVWWAA GGGLIKKKGG PVVAVKDGWQ DDPQLRGQQM MMIIQLSSLD DKVVTTNSLL QIIIIIWWVV GGGLLKKKGG PVVAVGEGFQ DDPKLRGQQM MMIIQLSSLD DKAATTNSLL QIIIIIWWVV GGGLLKKKGG PVVAVGEGFQ EEPKLRGQQM MMIIQLSSLD DKAATTNSLL QVVVVVWWAA GGGLLKKKGG EVVYVTEDEQ SSPKLRGQQM MMIIQLSSLD DKVVTTNSLL QVVVVVYYII GGGSVTTTEE NVVVLEGK-P EELKIEGQQM MMLLQLSSLD DKVVTTTSLL QVVVVVFFII GGGSISSSEE TVVVLEEH-E PPLKIEGQQM MMLLQLSSLD DKVVSSTSLL ---------- ---------- ---------- ------GAAK KKIIQLSSVD DKVVTTNSFF QVVVVVFFLL GGGAIRRRDD PRRVLNDEEA EEVKLLGQQM MMLLQLSSLD DRVVSSSSLL QLLLLLFFLL GGGAISSSDD PNNIVKDEER PPRKLEGQQM MMLLQLSSLD DKVVSSSSLL ---------- ---------- ---------- ---------- ---------- ---------- EKKKKKVVII DRRQV----- ---------- ---------M MMVVSQSSWD DKFFSSSSLL EKKKKKTTII GAAQV----- ---------- ---------M MMVVSSSSWD DQYYTTSSLL SDQFFYYPPP PEEGLKKGWW MVVVLN---- SGLLIDFFFF VDDGG----R HRRLSSASSY SNQFFYYPPP P--GLRRGWW MAAAVN---- EGLLLEFFFF VDDGG----R HRRLWWATSF SDQFFYYPPP PDDGVPPAAA QVVVAG---- DGLLLAYWWW VEEPP----R HRRLEECTSF SDQFFYYPPP PDDGVPPGVV EVVVAG---- NGLLLDYFFF VSSPP----R HRRLEECTSF SDQFFYYPPP PGGDRGGAAA MVVVAG---- NGLLLDFWWW VDDPP----R HRRLEECTSF GDQFFYYPPP PEEGIDDGWW MVVVLG---- NGIIFDFFFF LEEPP----R HRRLQQCSSY RDQFFYYPPP PDDGIKKGWW MVVVVN---- DGMMFDFFFF VDDGG----R HRRLQQASSY ADQFFYYPPP PVVGIRRGWW IAAAAD---- GGLLLDFFFF TEEGG----R HRRLEESSSY SDQFFYY--- -PPDLIIREE GSSSMVDVDD NGLLLNFLLL VDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPNLIIREE GSSSMIDVDD NGLLLNFLLL VDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPDLIIREE GSSSMIDVDD KGLLLNFLLL VDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPDLIIREE GSSSMIDVDD KGLLLNFLLL VDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPDLIIREE GSSSMVDVDD KGLLLNFLLL VDDGGPGPPL HRRYPPCSIW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SDQFFYY--- -PPDLIIREE GSSSMVDVDD KGLLLNFLLL VDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPDLIIREE GSSSMIDVDD KGLLLNFLLL VDDGGPGPPL HRRYPPCSIW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SDQFFYY--- -PPDMIIKEE GSSSMIDVDD KGLLLNFLLL VDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPDLLLKEE GAAAMIDVDD KGLLLNFLLL VDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPGLVVEKK GSSSIIDVDD KGLLINFFFF VDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPKLVVEQQ GSSSIIDVDD NGLLINFFFF VDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPELMMDKK GSSSIIDVDD KGLLINFFFF VDDGGPGPPL HRRYPPCSIW SVSFFYY--- -PPEIMMEKK GSSSIIDGDD KGLLINFFFF VDDGGPGPPL HRRYPPCSIW SDQFFYYGGG GQQDLVVKKK GSSSMIDVDD KGLLINFFFF VDDGGPGPPL HRRYPPCSIW KDQFFYY--- -PPEHVVKSS GAAAMVNIDD SKMMINFLLL IDDGGEGPPL HRRYPPCSIW KDQFFYY--- -PPENVVRSS GAAAMIDVDD THMMINFLLL IDDGGPGPPL HRRYPPCSIW SDQFFYY--- -PPNVVVKEE GSSSMIDVDD KGLLVNFLLL VDDGGPGPPL HRRFPPSSIL SDQFFYY--- -PPEMVVAAA GGGGILDIDD NGMMLNFLLL VDDGGPGPPL HRR------- SDQFFYY--- -PPKMVVSQQ GGGGIIDVDD NGIILNFLLL VDDAAPGPPL HRRYPPCSIW ---------- ---------- ---------- ---------- ---------- ---------- AD-------- -------KKK GKKKDYLKAA WGKKLVFAAA VDDYYGG--R HRRFGGLS-- AD-------- -------KKK GKKKDFLKLL WGKKLKFAAA IDDYYKG--R HRRFGGLAPA YP----- YP----- YPVR--- YPV---- YPV---- YP----- FP----- YP----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ANA---- ------- ------- DGRVQVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NNSAKAKKKK KQQQPAAATT PPPCCRRAPT GLTTTAQSSL LLPTTTTTAA LLTPGSSRAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YAAAAWFSAA AIIVASSPPP PRRREKGRRR RRSVVPGVVV VVEEESVQVV PSQQAAQQAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------LL ---------- ---------- ---------- ---------- ---------- ---------- MRRSSATLPP PLLNTTTPPP PHHHNLAPPP PPPHHPRPPP PPLLLLRRTI NVPPRRPPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MVPR DDFFYPSPKM AAPPPEEEDA VVCLTGTGNN ---------- ---------- -------AKP DDFFYPTPRD AAPPPEEEDA VVALVGTGNN ---------- ---------- -------MSP DDFFHASPEL AAPPPEEEEA TTLLPDFS-- ---------- ---------- -------MTP DDFFHASPKL AAPPPEEENA TTLLPDFS-- ---------- ---------- -------MTP DDFFYPSAKL AGPPPEEEKA TTMLPDAS-- ---------- ---------- -------ATP DDFFYPSPRL AAPPPEEETA VVMFPERK-- ---------- ---------- -------VTP DDFFYPSPRM AAPPPEEEKA VVRLPMAN-- ---------- ---------- -------ASP DDFFYPSPKM AAPPPEEERG VVLLPGRE-- ---------- ---------- ----MATTKC GGYYPTPLEA MGPPPEEEEV LLCIRNTGEE ---------- ---------- ---------- ---------- -GPPPEEEEV LLCIRNTGEE LPKKHAAAVV LIIAPARRRG LPPPHSTGKC GGYYPSPLEA MGPPPEEEEV LLCIGNTGEE ---------- ---------- ---------- ---------- MGPPPEEEEI LLCIRNTGEE ---------- ---------- ----MATGNC GGYYSTPLEA MGPPPEEEEV LLCIRNTGEE -EAAEAAATT LQQSVAQQQP RPPPTATGNC GGYYSTPLEA MGPPPEEEEV LLCIRNTGEE ---------- ---------- ----MATGNC GGYYSTPLEA MG-------- --------EE ---------- ---------- ----MATGNC GGYYSTPLEA MGPPPEEEEV LLCIRNTGEE LKEEPHHHAA QPPWFLSSSG LWWWTATGDC GGYYPTPQEA MGPPPEEEEV LLCIRNTGEE SGLLGDDDTT NTTELHTTTY TLLLSPTGNC GGYYSTPLEA MGPPPEEEEV LLCIRNTGEE ---------- ---------- ----MATGNC GGYYSTPLEA MGPPPEEEEV LLCIRNTGEE AHLLVQQQII MEEGAAAAAV TAAANGKCHK GGYYATPLEA MGPPPEEEKV VVCVNGTGNN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MAGSC GGYYKSPLDA MGPPPEEEEV LLCIRSTGNN ---------- MAATVLDDDH VVVVKS-GCS GGYYASPIES MGPPPEEESI VVAVAGTGEE ---------- MGGTVLQQQH VVVVVNNGCS GGYYASPLEA MGPPPEEETI VVAVAGTGEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MLG GGYYATPLAA MGPPPEEEKI VVAVTGTGDD ---------- ---------- MAAANGACGT GGYYATPLEA MGPPPEEEKL VVCVNGTGNN ---------- ---------- -MMMCGLHG- GGYYASPADA IGPPPEEEEL VVAP--NADD ---------- ---------- -MMMCPLHG- GGYYASPADA IGPPPEEEEL VVAP--HADD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MSKC GGYYATPLDA VGPPPEEEKL VVCVPNLDEE ---------- ---------- ---------- ---------- MGPPPEEEKL TTTVPNLDPP ---------- ---------- ---------- MMLLIT--DI LLDDDRRRFY SSWLGDIRYY MREEF----- ---------A AAAALAMPFF AATTCQSPYM PTGGGEEEEV VVTLVEGMDD MRIIVGGGSS MHHFALRRRA VSSSLALPAR AATTCASPYM KTGGGEEEDV VVTLAEGVDD RRRAADFFFV VNNPKSSSEE TYKKIVEEEE LLYYINNLHH GNNNCSSSC- PPNNGKKPPN AAAPPDFFFV VDDPKSSSPP TYKKVLDDDD LLYYIGGLHH GNNNCSSSC- PPNNAKKPPF RRRPPDAAAV VKKPGSSSSS TYKKIVTTTT MMNNTGGFHH GNNNCSSSS- PPLLTHHAAF KKKPPDAAAV VKKPGSSSPP TYQQIVTTTT MMNNKGGFHH GNNNCSSSS- PPLLAHHAAF KKKPPDGGGV VDDPTSSSEE KFQQILIIII MMNNKGGFHH GNNNCSSSS- PPLLTHHAAF QQQPPDAAAV VDDPASSSPP RYSSIVAAAA MMHHAGGLHH GNNNCSSSC- PPNNAHHPPH KKKPPDAAAV VDDSQSSSSS TFQQVTDDDD MMYYTGGLHH GNNNCSSSC- PPNNAHHPPH RRRPPDAAAV LDDPDSSSGG TYQQIVEEEE MMNNAAALHH GNNNCSSAC- PPYYAHHPPH AAAPPDYYYT VDDPKSSSPP QYQQVLPPPP MMYYLKKLHH GNNNCSSS-- ----FDDSST AAAPPDYYYT VDDPKSSSPP HYQQVLPPPP MMHHLKKLHH GNNNCSSS-- ----FDDSST AAAPPDYYYT IDDPKSSSPP QYQQVLPPPP MMNNLRRLHH GNNNCSSS-- ----FDDSST AAAPPDYYYT VDDPKSSSPP QYQQVLPPPP MMHHLKKLHH GNNNCSSS-- ----YDDIIT AAAPPDYYYT VDDPKSSSPP QYQQVLPPPP MMNNLKKLHH GNNNCSSS-- ----FDDSST AAAPPDYYYT VDDPKSSSPP QYQQV----- ---------- ---------- ---------- AAAPPDYYYT VDDPKSSSPP QYQQVLPPPP MMNNLKKLHH GNNNCSSS-- ----FDDSST AAAPPDYYYT VDDPKSSSPP QYQQVLPPPP MMNNLKKLHH GNNNCSSS-- ----FDDSST AAAPPDYYYT VDDPKSSSPP QYQQVLPPPP MMYYLKKLHH GNNNCSSS-- ----FDDSST AAAPPDYYYT VDDPKSSSPP QYQQVLPPPP MMNNLKKLHH GNNNCSSS-- ----FDDSST AAAPPDYYYT VDDPKSSSPP QYQQVLPPPP MMNNLKKLHH GNNNCSSS-- ----FDDSST KKKLLDYYYT LDDPSSSSPP TYQQVLPPPP VVHHIGGLHH GNNNCSSS-- ----HDDPPS ---------- ---------- ---------- MMNNTNNLHH GNNNCSSS-- ----YDDAAS KKKPPDYYYT VDDPKSSSPP SYQQVLPPPP MMNNVNNLHH GNNNCSSS-- ----YDDSSS KKKPPDYYYT VDDPSSSSPP TYKKVLPPPP VVYYVGGLHH GNNNCSSS-- ----HDDPPS KKKPPDYYYT LDDPNSSSPP TYKKVLPPPP VVYYVGGLHH GNNNCSSS-- ----HDDPPS ---------- ---------- ---------- MMFFVGGLHH GNNNCSSS-- ----HDDAAS KKKPPDYYYT VDDPSSSSPP SYSSVLPPPP MMFFVGGLHH GNNNCSSS-- ----HDDAAS KKKPPDYYYT VDDPNSSSPP TYQQVLPPPP VVHHVGGLHH GNNNCSSS-- ----HDDPPS GGGPPDAAAT VNNPESSSDD TFQQVVDDDD VVHHIGGVHH GNNNCSSS-- ----HKKPPT GGGPPDAAAT VNNPESSSEE TFQQIVDDDD VVNNIGGVHH GNNNCSSS-- ----HKKPPT ---------- ---------- ---------- ---------- ---------- ---------- HHHGGDYYYT VDDPASSSPP TYQQVTYYYY TTSSKHHLHH GNNNCSSSFV PP--GKKEEV HHHGGDYYYT VDDPESSSPP TYQQITFFFF TTRRKGGLHH GNNNCSSSYV DDEESKKTTV DDDIITDDDN MVVGQVVVFF LGSSVGPPPP VVVVLEEEDD QTTTRIIL-- -----KKRRV EEEQQDKKKT LRRPGSSSAA TRQQVVSSSS VVGG-RRAHH GSSS------ ---------- EEEQQDKKKT ANNPKSSSPP QYKKVLSSSS VVGG-RRAHH DTTT------ ---------- NERRFLIVPG LLSSYYIDDP PNNREEKIKV VIIIEPPEEV KKSYYSSSRR TTHCGPYISA FERRYLIVPA LLSSYYVDDP PDDRRRAAKI IVVVEPPEVA VVTYYTTTKK TTHCGPYISA FERRFLIIPG LLSSYYIDDP PHHTQQRHKI IIIIEPPDEI LLTYYSSSRR TTHCGPYVST FERRYLIIPG LLSSYYIDDP PDDTKKKHKI IIIIEPPEEV FFTYYSSSRR TTHCGPYVST FERRYLIIPG IISSYYVDD- -EELKKKHKI IIIIEPPEEV FFTYYSSSRR TTHCGPYVST HERRYLVVPG LLSSYYLDDP PDDLKKFAKV VIIIEPPETL AATYYSSSRR TTHCGPYVTA HERRYLVVPD IISSTTLDDP PDDTQQKVKV VIIIDPPNEL AATYYAAARR TTHCGPYISA HERRYLIVPG IISSHHVDDP PDDREERVKV VIIIEPPEEL HHTYYSSSRR TTHCGPYVSA TSRRKLILPG LLSSYYVDDS SEERAAKHKV VIIIEAASEI QQCVVSSSNN TTHCLAVMVN TSRRKLILPS IISSYYVDDS SEERAAKHKV VIIIEPPNEI HHCLLGGGNN TTHCLAVMIS TSRRKLMLPC LLSSYYVDDS SDDRAAKHKV VIIIEAAEDI HHCLLGGGYY TTHCLAVMIS TARRKLVLPA LLSSYYVDDT TEERAAKHKV VIIIEPPKDI HHCLLGGGFF TTHCLPVMVS TSRRKLVLPS LLSSYYVDDS SEERAAKHKV VIIIEPPEDI HHCLLAAAFF TTHCLAVMIS ---------- ---------- ---------- -----PPKDI HHCLLAAAFF TTHCLAVMIS TSRRKLVLPS LLSSYYVDDS SEERAAKHKV VIIIEPPKDI HHCLLAAAFF TTHCLAVMIS TSRRKLVLPS LLSSYYVDDS SEERAAKHKV VIIIEPPKDI HHCLLAAAFF TTHCLAVMIS TSRRKLVLPS FFSSYYVDDT TEERAAKHKV VIIIEAAKDI HHCLLGGGTT TTHCLPVMIS TSRRKLVLPS LL-------- ---------- ---------- ---------- ---------- TSRRKLVLPS LLSSYYVDDS SEERAAKHKV VIIIEPPKDI HHCLLAAAFF TTHCLAVMIS SKRRFLILPS LLSGYYVDDT TDDRTTSHKV VVVVESSEDI AAILLGGGFF TTHCLAIMIS SVRRKLILPC LLSSYYVDDT TDDRAARHKT TVVVEPPYEV FFCLLAAANN TTHCLGIMIS SVRRKLILPC LLSSYYVDDS SDDRAARHKT TVVVEPPYEV FFCLLAAANN TTHCLGIMIS SERRFLIAPS LLSGYYIDDT TNNRSSSHKV VVVVDPPADI IITLLAAAYY TTHCLALMIS SQRRFLIVPG IISGYYIDDT TNNRAASHKV VVVVEPPEDI SSTLLAAAYY TTHCLAIMIS SDRRYLVLPS LLSGYYIDDE ENNRAASYKY YVVVDPPKEI AATLLAAAYY TTHCLAILVS SDRRYLVLPS LLSGYYIDDE ENNRAASYKY YVVVDPPKEI AATLLAAAFF TTHCRTILVS SSRRFLILPS LLSGYYVDDK KDDRAAAHKV VVVVEAAEDI AATLLGGGFF TTHCLAIMIS TKRRHLIVPC LLSDYYINNN NEERKKYEHT TIIIEPPSKL HHNLLSSSFF TTHCLAIMIS TKRRHLIVPC LLSDYYINNN NEEREEYQHT TIIIEPPSKL HHNLLSSSFF TTHCLAIMIS -----MVPRK LLSGGGVFFG G--------- ---------- ---------- ---------- VTRRRLVLPC LLSDFFIDDT TDDRAAKAKV VIIIEGG-DV LLACCTTTAA TTHCLPIMIS VKRRRLVLPS LLSDYYLDDT TDDRKKEVKT TIIIDGG-DV LLHVVTTTAA TTHCLAIMIS VGGGQMLQLS LLGKYYTTTY YSSWDDQYP- --------DL IILLLAAAII TTDYQPLKQD -DRRFFWTGG LLTNFFFDDS SDDSNNKHKT TIIIDTT-FV KKGVVVVVGG TTFALPMITG -DRRYLWAGG LLTSFFFDDS SDDARRVSKT TIIITDD-FV EEGVVVVVGG TTYALPLITG AAALL--EE- GGGGGILMLD HYSEPLWEDR GY-------- ----DFFWWN L-PPEVLVVS AAALL--DDR GGGGGIFLLD HDTEPIWEYR GY-------- ----DFFWWN L-PPGVMIIT TTTLLGKDDT GGPPGIFIMD CETDVLWEDR GD-------- ----DFFWWN L-PPDYMVVS TTTLLGKDDT GGPPGVFIMD CETEVLWEDR GT-------- ----DFFWWN L-PPDYMVVT TTTLLGEDDT GGPPGIFILD CETEILYEDR GT-------- ----DFFWWN L-PPDYMVVS AAALL--EE- GGGGGIAMLD AQSEPLWEER GY-------- ----DGGWWH L-GGDTLVVT AAALL--EE- GGGGGIFILD HDNEVLWEDR GY-------- ----DFFWWH L-GGDTLLLT AAALL--EE- GGGGGVFVMD HESDPLWEER GQ-------- ----DFFWWH L-GGDTMVVT NNNTT--LLG GGGGSFVLLD GETEVKWEPG GP-------- ----DFFYYQ P-RRNVMVVS SSSSS--PPG GGGGGFVLLD GETEVKWEPG GP-------- ----DFFYYQ P-RRNIMVVS SSSTT--SSG GGGGGFVLLD GETEVKWEPG GP-------- ----DFFYYQ P-RRNVMIIS SSSTT--PPG GGGGGFVLLD GKTEVKWEPG GP-------- ----DFFYYQ P-RRNVMIIS SSSSS--VVG GGGGGFVLLD GETEVKWEPG GP-------- ----DFFYYQ P-RRNVMIIS SSSSS--VVG GGGGGFVLLD GETEVKWEPG GP-------- ----DFFYYQ P-RRNVMIIS SSSSS--VVG GGGGGFVLLD GETEVKWEPG GP-------- ----DFFYYQ P-RRNVMIIS SSSSS--VVG GGGGGFVLLD GETEVKWEPG GP-------- ----DFFYYQ P-RRNVMIIS SSSTT--PPG GGGGGFVLLD GETEVKWEPG GP-------- ----DFFYYQ P-RRNVMIIS ---------- ---------- ---------- ---------- ---------- ---------- SSSSS--VVG GGDDGSLVLL P-RECS---- ---------- ---------- ---------- SSSCC--KKG AAGGNGFLLL DSENVKGSRL FS-------- ----THHYYE NYAAGLFWWS SSSSS--PPG GGGGGFVLLD GETEVKWEEG EP-------- ----DFFYYQ P-RRNVMIIS SSSSS--PPG GGGGGFVLLD GETEVKWEEG EQ-------- ----DFFYYQ P-RRNVMIIS SSSCC--KKG AAGGNGFLLL DSDNVKWEPG HL-------- ----DFFYYQ P-RRNTMIIS SSSCC--KKG AAGGNGFLLL DSENVKWEPG HL-------- ----DFFYYQ P-RRNTMIIS SSSCC--EEG AAGGNGFLLL DSDNIKWEPG HL-------- ----DFFYYQ P-RRKTMIIS SSSCC--EEG AAGGNGLLLL DSDNIKWEPD IL-------- ----HFFYYQ P-RRKTMIIS SSSCC--KKG AAGGNGFLLL DSENVKWEPG HL-------- ----DYYYYQ P-RRKTMIIS SSSTT--AAG PPGGNFLLLD GKTEPKWPDE KP-------- ----DFFYYQ P-RRNVMIIS SSSTT--AAG PPGGNFLLLD GKTEPKWPDG KP-------- ----DFFYYQ P-RRNIMIIS ---------- ---------- ---------- ---------- ---------- ---------S SSSII--AAG AAGG-DFVEF DKNELVWSGD RL-------- ----DYYYYQ P-HHNVMVVA SSSVV--AAG AAGG-DFILF DSDNCIWTGD KL-------- ----DFFYYQ P-YYDVMVVS DDDGG--SSS PPLLNGIQTS KHEGLSGESQ FI-------- ----SNNNNN G---EKSEES GGGLL--DDH GGTTALVEYN DDGYVAWMTA DQVVAVGGGA ADGGDIIAAL I-RRNVMLLT GGGLL--KKH GGTTALVEYT NAGYVAWITD GRIIKTGGGK ADGGDVVAAL P-RRNLLVVT SSAVVVPN-- TTTIEDGKL- -RRYYGGGNN NRIIIIFDRR KRRRIIHHLL TTTLGGNRRA SSTVVVPR-- CCCFEEGSLG GAAYYGGGNN NKLLLLVDAA KRHHLLYYII DDDLGGHRRV SSALLLPP-- QQQFENGVPN NKKYYGGGHH HRLLLLFDRR ARNNVVQQII DDDLGGHQQA SSALLLPP-- QQQFENGVPN NKKYYGGGHH HRLLLLFDRR ARNNVVQQII DDDLGGHQQA SSGLLLPP-- QQQFENGVPN NKKYYGGGHH HKIIIIFKRR DRNNVVQQII DDDLGGHQQA SSGTTTPD-- MMMVEDGVPA ARRYYGGGRR RRLLLLFDTT RRHHLLQQII DDDFGGHQQV SSGTTTPR-- MMMVESGLGG GKKYYGGGHH HRLLLLVDYY RRHHLLQQLL DDDLGGYQQA SSGTTTPN-- MMMIEGGDPK KGGYYGGGRR RRLLLLIDRR RRHHLLQQLL DDDVGGHQQV TTAAAAPN-- VVVFKDGPAG GLLYYGGGSS SRIIIIVDQQ RHIIIIQQLL QQQMTTDGGI TTAAAAPN-- VVVFKDGPAG GLLYYGGGSS SHIIIIVDQQ RHIIIIQQLL QQQMKKDGGI TTAAAAPN-- VVVFRDGPAG GLLYYGGGSS SHLLLLVDQQ RHIIIIQQLL TTTLQQDGGI TTAAAAPN-- VVVLRDGPAG GLLYYGGGSS SHLLLLVDQQ RRIIVVQQLL PPPLQQDGGI TTAAAAPN-- VVVLRDGPAG GLLYYGGGSS SHLLLLVDQQ HHIIVVQQLL SSSLKKDGGI TTAAAAPN-- VVVLRDGPAG GLLYYGGGSS SHLLLLVDQQ RHIIVVQQLL SSSLKKDGGI TTAAAAPN-- VVVLRDGPAG GLLYYGGGSS SHLLLLVDQQ RHIIVVQQLL SSSLKKDGGI TTAAAAPN-- VVVLRDGPAG GLLYYGGGSS SHLLLLVDQQ RHIIVVQQLL SSSLKKDGGI TTAAAAPN-- VVVVQNGPAG GLLYYGGGKK KHLLLLVDQQ RHIIVVQQLL LLLMPPDGGI ---------- ---------- ---------- ---------- ---------- ---------- AAAHHHSN-- LLLRLTGDYS SRRVVAAAGG GITTTT---- ---------- ---------- WWCCCCSL-- FFFYTTGLMS SGGVVHHHVV VISSSSLNII MRIIDDEELL PPPLQQDQQG TTGAAAPK-- AAAFALGMEG GMMYYGGGHH HSLLLLVDTT EHRRIIQQII DDDLGGDGGI TTGAAAPK-- AAAFALGMEG GHHYYGGGHH HSLLLLVDTT EHLLVVQQII DDDLGGDGGI TTGAAAPT-- AAAFTKGLQG GLLYYGGGRR RHLLLLCQAA RGLLRRQQLL DDDLGGTGGL TTGAAAPK-- AAAFLQGLQG GLLYYGGGRR RHLLLLVSPP GGIIKKQQLL DDDLGGKGGL TTGAAAPK-- AAAFSKGLQG GLLYYGGGSS SHLLLLVSPP GGMMKKQQII DDDLGGTGGL TTGAAAPK-- AAAFSKGLQG GLLYYGGGSS SHLLLLVSPP GGIIKKQQII DDDLGGTGGL SSGAAAPA-- AAAFRTGLQG GLLYYGGGRR RHLLLLVDPP GGLLKKQQLL DDDLGGTGGL TTGSSSPN-- HHHIKKGPAG GLLYYGGGNN NSVVVVIEDD SKYYLLQQII DDDLPPLGGL TTGSSSPN-- HHHIKKGPAG GLLYYGGGNN NSVVVVIEDD TKHHLLQQII DDDLPPRGGL IIGGGGPV-- TTTVCRDLKP PLLVVIIIKK KCKKKKV--- ---------- ---------- SSGAAAPK-- LLLFRRGPTT TQQYYGGGCC CRLLLLFRQQ ERLLFFQQII DDDLGGDGGT SSGAAAPN-- KKKWRRGNVS SQQYYGGGCC CRLLLLFKSS TQLLYYQQII DDDLGGDGGT DDDEEEPI-- MMMAFESSFP PLLKKPPPQQ QHVVVVEL-- ---------- ---------- SSTGGGWSNY MMMMDFGLQK KRRFFGGGNN NTIIIIQDHH TRPPKKKKFF NNNVPPP--- SSTGGGWNNY MMMMDFGLAK KHHFFGGGNN NTVVVVTDHH TKPPKKKKFF DDDVPPP--- A--------- LLPLLLDPKL MMMMMGFINV SSSLLLLKKD LSIWLW-DDG KAAAVEEEII V--------- VVPLLLDPKL MMMMMGFVNV NNNTTTTKKD LSIWLW-DDG KAAAVDDDII A--------- VVPAAADPRE YYYYYGFVGV DDDTTTTTTN LEIWTW-GGG KVVVTTTTII A--------- VVPAAADPRE YYYYYGFVGV DDDTTTTTTN LEIWTW-GGG KAAATTTTII A--------- IIPAAADPKD YYYYYGFCGV DDDTTTTTTN LQIFTWKDDG TAAATTTTII V--------- LLPAAADPKA YYYYYGFVNV SSSLLLLKKD LSIWTW-KKD KVVVVEEEII A--------- LLPAAADPKA YYYYYGFMNV SSSLLLLKKD LSIWLW-NNG SLLLVDDDII V--------- LLPAAADPRT YYYYYGFVGV SSSLLLLEED LSVWLW-NNG SIIIVEEEII I--------L IIFLLLDPAT QQQQQGFVGA SSSSSSSNNI QRKNEE---- -----WWWSS I--------L IIFLLLDPAT QQQQQGFVGA SSSSSSSNNI QRKNEG---- -----WWWSS I--------L IIFLLLNPAA QQQQQGFVGA SSSSSSSTTI QRKNQG---- -----WWWSS I--------L IIFLLLNPAA QQQQQGFVGA SSSSSSSTTI QRKNED---- -----WWWSS I--------L IIFLLLNPAA QQQQQGFVGA SSSSSSSTTI QRKNEG---- -----WWWSS I--------L IIFLLLNPAA QQQQQGFVGA SSSSSSSTTI QRKNEG---- -----WWWSS I--------L IIFLLLNPAA QQQQQGFVGA SSSSSSSTTI QRKNEG---- -----WWWSS I--------L IIFLLLNPAA QQQQQGFVGA SSSSSSSTTI QRKNEG---- -----WWWSS I--------L IIFLLLDPAS QQQQQGFVGA SSSSSSSTTI QRKNEG---- -----WWWSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GNNNNNIIIL LLSIIIWKIN QQQQQDYDVE SSSFFFFSSG RGDPDA---- -----VVVVV I--------L IIFLLLDPAA QQQQQGLVGA SSSSSSSTTV FRKEKD---- -----WWWAA I--------L IIFLLLNPAD QQQQQGLVGA SSSSSSSSSI FRKEKD---- -----WWWAA L--------L IIFLLLDPKD TTTTTGFVGA SSSSSSSNNM IRKTQD---- -----WWWSS L--------L IIFLLLDPKD TTTTTGFVGA TTTSSSSNNM IRKTQD---- -----WWWNN L--------L IIFLLLDPKD TTTTTGYVGA SSSSSSSNNM IRKNSD---- -----WWWSS L--------L IIFLLLDPKD TTTTTGFVGA SSSSSSSNNM IRKNSD---- -----WWWSS L--------L VVFLLLDPKD TTTTTGYVGA TTTSSSSNNM VRKTAD---- -----WWWSS L--------L VVFLLLEPSE HHHHHAFVGA GGGSSSSGGI FRPVEE---- -----HHHAA L--------L VVFLLLEPSE HHHHHAFVGA GGGSSSSAAI FRPDEK---- -----QQQTT ---------- ---------- ---------- ---------- ---------- ---------- T--------L IIFLLLNPEN QQQQQGYVGA XXXXXXXXXX XX-------- ---------- T--------L IIFLLLNPKA EEEEEGFVGA NNNAAAAKKV FHKKSD---- ----FAAAKK ---------- ---------- ---------- ---------- ---------- ---------- ---------L IIFPPPGSAN YYYYYAFSTA TTTSSSSQQL WLEDDA---- ---------- ---------L IICAAAGEHN YYYYYCFTSA TTTSSSSQQL WLEDGE---- ---------- PAEEEEPLGG NLPPEEIIIK PAPPVTDDIS LDDKKFLYSL WGIIGVVRRD DDDNNPKPVL EAQQQQPFGG PLPPPPVVVK DMPPVTDDIS LDDRRFLYSL WGLLGLLRRD DDDNNPQPRL PAEEEEPAAA ELPPPPLLLQ GAPPVTDDLS LDDRRFLYSC WGTTGMMRRD DDDDDPNPVL PPEEEEPAKK KLPPPPLLLQ GAPPVTDDLS MDDRRFLYSC WGTTGMMRRD DDDDDPKPKL DPVVVVPAAA DLPPDDLLLK GAPPVTDDLS LDDKKYLYAC WGLLGMMHHD DDDDDPNPVL PAEEEEAAPP QLPPPPVVVK GAPPVTDDLS MDDRRFLYSC WGTTGLLLLD DDDDDPEPKL PAEEEEPAEE QLPPPPIIIK PAPPVTDNLS VDDRRFLYSC WGTTGLLHHD DDDDDPNPRL PAEEEEPAPP QLPPPPLLLK DAPPVTDNLS LDDRRFLYSC WGTTGLLRRD DDDDDPNPRH VEKKKKVIVV SKKKVVKKKW MEPGITDLLS LDDRRFLYSN WLHHGIIRRD DDDNNPKPRL VEKKKKVIVV SKKKVVKKKW MEPGITDLLS LDDRRFLYSN WLHHGIIRRD DDDNNPKPRL VEKKKKVIVV PKKKVVKKKW MEPGITDLLS LDDRRFLYSN WLHHGLLRRD DDDDDPRPRL AQKKKKVIVV PKKKVVKKKW MEPGITDLLS LDDHHFLYSN WLHHGIIRRD DDDDDPRPRL VEKKKKVIVV PKKKVVKKKW LEPGITDLLS LDDRRFLYSN WLHHGLLRRD DDDDDPRPRL VEKKKKVIVV PKKKVVKKKW LEPGITDLLS LDDRRFLYSN WLHHGLLRRD DDDDDPRPRL VEKKKKVIVV PKKKVVKKKW LEPGIT---- ---------- ---------- ---------- VEKKKKVIVV PKKKVVKKKW LEPGITDLLS LDDRRFLYSN WLHHGLLRRD DDDDDPRPRL VEKKKKVIVV PKKKVVKKKW MEPGITDLLS LDDRRFLYNN WLHHGMMRRD DDDDDPRPRL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LKRRRRKLLL YAVVVVAAAF GSSNFPPWIF FSDLLLIILS ---------- ---------- AEKKKKVIVV SKKKVVEEEW AEPGITDLIS LDDRRFLYSN WLHHGIIRRD DDDDDPNPKL AEKKKKVIVV SKKKVVEEEW PEPGITDLIS LDDRRFLYSN WLHHGIIRRD DDDDDTNPKL HELLLLAIVV PLKKVVQQQW IEPGITDLIS LDDRRFLYVN WLHHGIIRRN NNNDDLNPVL HEIIIIVIVV PLKKVVQQQW FEPGITDLIS LDDRRFLYVN WLHHGIIRRN NNNDDVNPKL YEIIIIVIVV PLKKVVEEEW IEPGITDLIS LDDRRFLYVN WLHHGIIRRN NNNDDPNPVL HEVVVVVIVV PLKKVVEEEW IEPGITDLIS LDDRRFIYVN WLHHGIIRRN NNNDDPNPVL HEVVVVAIII PLKKVVRRRW IEPGITDVIS LDDRRYLYVN WLHHGIIRRN NNNDDPKPVL ATLLLLVAII SKKKVVSSSW AEPAITDLIS MDDRRFLYSC WLHHGIIRRD DDDDDPKVKL ASLLLLVAII SKKKVVEEEW ADPAITDLIS MDDRRFLYSC WLHHGIIRRD DDDDDPNPKL ---------- ---------- ---------- ---------- ---------- ---------- ---------- --QQGGEEEG EMGGMTDLIS LDDRRYLYSN WRHHGVVRRD DDDDDRNPRL KVIIIIDIGG LVDDTTGGGG VDGGISDIIS LDDRRFLYNC WRHHGVVRRD DDDDDPNPKL ---------- ---------- ---------- ---------- ---------- ---------- --------WW AKAAVVAAAI GAIPPVDSIA ADDQQTLWNS FMDDGTTRRD DDDDDPKPFQ --------WW AKAAVVAAAI GAVPPVDSIS NDDSSRLWNT FMDDGTTRRD DDDDDPHPRQ TGKVLGGGAA DHHHPPP--- ---------- -----ATTPP MMLLESSSGR RVVVTTLYTW AGRVIGGGEE PHHHPPP--- ---------- -----STTPP MMIISSSSGR RVIITTLYSW AGSVIGGGAA PHHHPPP--- ---------- -----NAAPP MMVVESSSGR RVWWTTLYTW AGSVIGGGTT PHHHPPP--- ---------- -----NAAPP MMVVESSSGR RVWWTTLYTW TGKVIGGGTT PHHHPPP--- ---------- -----NGGPP MMVVESSSGK RVWWTTLYTW TGKVIGGGAA THHHPPPG-- ---------- ---AAKNNPP MMVVESSSGR RVFFTTLYAV TGKVIGGGAA GHHHPPP--- ---------- ---AATNNPP MMVVESSSGR RVFFTTLYAW TGSVLGGGAA AHHHPPP--- ---------- -----ANNPP MMVVESSSGR RVFFSSLYSW TGQILGGGGG GSSSVVVQLE EEE--DEETC QEEVVKPPPP MMIIQSSSGK RLAATTLYDW TGQILGGGGG GSSSVVVQLE EEE--DEETC QEEVVKPPPP MMIIQSSSGK RLVVTTLYAW TGQLLGGGGG GPPPVVVQLE EEE--DEEKS QEEVVKPPPP MMIIQSSSGK RLVVTTLYAW TGQLLGGGDD GPPPVVVQLD DDD--DEEDS QEEVVKAAPP MMIIQSSSGK RLVVTTLYAW TGQLLGGGGG GPPPVVVQLE EEE--DEEKS QEEVVKAAPP MMIIQSSSGK RLIITTLYAW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TGQLLGGGGG GPPPVVVQLE EEE--DEEKS QEEVVKAAPP MMIIQSSSGK RLIITTLYAW VGQILGGGGG GPPPVVVQLE EEE--DEEKS QEEVVKPPPP MMIIQSSSGK RIVVTTLYDW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VGQILGGGGG GPPPVVVTLE EEE--DDDEC QDDVVKPPPP MMIIQSSSGK RLVVTTLYKW VGQILGGGGG GPPPVVVTLE EEE--DEEEC QDDVVKPPPP MMIIQSSSGK RIVVTTLYIW TGQLVGGGGG SPPPVVVAIG GGG--EGGTW QDDIIQRRPP MMIIQTTTGK RLVVTTLFAW TGQVAGGGGG SPPPVVVVVK KKK--DGGTW QDDIIQRRPP MMIIQSSSGK RLVVTTLFAW TGQIVGGGGG SPPPVVVKVG GGG--EGGSF QDDIIKRRPP MMIIQSSSGK RLAATTLFAW TGQIVGGGGG SPPPVVVKVG GGG--EGGTF QEEIIKRRPP MMIIQSSSGK RLAATTLFAW AGQVAGGGGG SEEEVVVVVT TTT--EDDEE QSSVVKRRPP MMIIQSSSGK RIVVTTLFRW NSQVIGGGEE SNNNVVVKLE EEE--GKK-- PEEVVKEEPP MMLLQSSSGK RLVVTTLYKW NSQVIGGGEE TTTTVVVKLE EEE--EHH-- EPPVVKEEPP MMLLQSSSGK RLVVSSLYKW ---------- ---------- ---------- --------PP KKIIQSSSGK RLVVTTFYTW TGQVLGGGDD APPPRRRRLN NNN--DEEKE AEELLKLLPP MMLLQSSSGR RLVVSSLFPW TGQLLGGGDD LPPPNNNVVK KKKEEDEEKE RPPVVKEEPP MMLLQSSSGK RLVVSSLYPW ---------- ---------- ---------- ---------- ---------- ---------- IYEKIDRR-- ---------- ---------- ---------- MMVVSSSSGK RVFFSSLLNW VYEKIGAA-- ---------- ---------- ---------- MMVVSSSSGQ RLYYTTLLNW DFFYPPKKGW KKKKLNNNAN ------SSSS GEDKFFFFG- -ARSHHVDDD YYYCYYYPP- NFFYPPRRGW KKKKVNNNVN ------EEEE GEEKFFFFG- -ARAHHVDDD FFFCYYYPP- DFFYPPPPAA LLLLAHHHAG ------DDDD GTADYWWWP- -YRAHHIDDD FFFCYYYPPS DFFYPPPPGV MMMMANNNVG ------NNNN GEDKYFFFP- -YRAHHIDDD FFFCYYYPPS DFFYPPGGAA MMMMANNNVG ------NNNN GTDKFWWWP- -YRSHHIDDD FFFCYYYPPS DFFYPPDDGW KKKKLDDDAG ------NNNN GEDPFFFFP- -HRPHHVDDD YYYCYYYPP- DFFYPPKKGW KKKKVDDDVN ------DDDD GQDPFFFFG- -QRVHHIDDD YYYCFFFPP- DFFYPPRRGW KKKKAEEEAD ------GGGG GSDPFFFFG- -LRPHHIDDD YYYCYYYPPS DFFY--IIRE VVVVMLLLQV DVVVDTNNNN GKNPFLLLGP PALAHHLDDD WWWI------ DFFY--IIRE VVVVMLLLQI DVVVDTNNNN GKNPFLLLGP PALAHHLDDD WWWI------ DFFY--IIRE VVVVMLLLQI DVVVDTKKKK GKNPFLLLGP PALAHHLDDD WWWL------ DFFY--IIRE VVVVMLLLQI DVVVDTKKKK GTNPFLLLGP PALAHHLDDD WWWL------ DFFY--IIRE VVVVMLLLQV DVVVDTKKKK GKNPFLLLGP PALAHHLDDD WWWI------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DFFY--IIRE VVVVMLLLQV DVVVDTKKKK GKNPFLLLGP PALAHHLDDD WWWI------ DFFY--IIRE VVVVMLLLQI DVVVDTKKKK GKNPFLLLGP PALAHHIDDD WWWL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DFFY--IIKE VVVVMLLLQI DVVVDTKKKK GKNPFLLLGP PVLAHHLDDD WWWV------ DFFY--LLKE VVVVMLLLQI DVVVDTKKKK GKNPFLLLGP PVLAHHIDDD WWWI------ DFFY--VVEK HHHHILLLQI DVVVDTKKKK GKNPFFFFGP PALAHHMDDD WWWI------ DFFY--VVEQ HHHHILLLQI DVVVDTNNNN GKNPFFFFGP PSLAHHMDDD WWWI------ DFFY--MMDK HHHHIIIIQI DVVVDTKKKK GSNPFFFFGP PALAHHMDDD WWWI------ VFFY--MMEK HHHHIIIIQI DGGGDTKKKK GTNPFFFFGP PSLAHHMDDD WWWI------ DFFYGGVVKK HHHHMLLLQI DVVVDTKKKK GSNPFFFFGP PSLAHHMDDD WWWI------ DFFY--VVKS TTTTMVVVQV NIIIDPSSSS KENRFLLLGP PYLAHHMDDD WWWI------ DFFY--VVRS TTTTMLLLQI DVVVDPTTTT HVNKFLLLGP PYLAHHMDDD WWWI------ DFFY--VVKE VVVVMLLLQI DVVVDTKKKK GTNKFLLLGP PCLAHHIDDD LLLA------ DFFY--VVAA TTTTIVVVQL DIIIDVNNNN GKNEFLLLGP PGLPHHM--- ---------- DFFY--VVSQ HHHHIVVVLI DVVVDTNNNN GSNEFLLLAP PSLPHHMDDD WWWLAAANND ---------- ---------- ---------- ---------- ---------- ---------- D-------KK DDDDDAAAQY LKKKAYWWWW GEVEFAAAY- --RAHHMAAS ---------- D-------KK DDDDDEEEQF LKKKLYWWWW GEKEFAAAY- --RPHHMAAG AAAGDDDGGN ------- ------- KKKKKR- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLLLLVV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158SAKKPEPCTT PGGTTTAARR LLADSSSLPP PTTAAAQLLS LTSSPVVVRI YYQQAAWFFF gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- MMAARSATTT gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSIQVLLLSS SSEESRRRKK KKTTRSVVGL EEIAAQQVVV PPSQAAVQHH HHWWLLPAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------EFFF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM MMGGLLKTTT ---------- ---------- ---------- ---------- --------KK KKNNSSGQQQ ---------- ---------- ---------- ---------- ---------- ---------- PPLNNRRRPT TPNNPPPPAA AASSPPHHRV LLTVVRRIII NNVPRRLPPP PPHHAAHHHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMR--- ---------- ---------- ---------- ---------- ---------- ----MMRPPP ---------- -MAPPRDDDD PPPPYYPPMM KKKPPEEDYY YCCCCLLGTT TINAFFIAVV ---------- ---KKPDDDD PPPPYYPPDM RRRPPEEDYY YAAAALLGTT TVNPFFLAVV ---------- ---SSPDDDD PPPPHHPPLM QQQPAEEEYY YLLLLLLDFF F--PAALAVV ---------- ---TTPDDDD PPPPHHPPLM EEEPAEENYY YLLLLLLDFF F--PAALAVV ---------- ---TTPDDDD PPPPYYAALM EEEPVEEKFF FMMMMLLDAA A--PGGLAVV ---------- ---TTPDDDD PPPPYYPPLA KKKPPEETYY YMMMMFFERR R--PAAIAVV ---------- ---TTPDDDD PPPPYYPPMV KKKPAEEKYY YRRRRLLMAA AG-PAAMCVV ---------- ---SSPDDDD PPPPYYPPMM QQQPREERYY YLLLLLLGRR R--PAALGVV ---------M MTKKKCGGGG PPPPPPLLAK ---PREEEYY YCCCCIINTT TTEPYYLATT ---------- ---------- ---------M ---PREEEYY YCCCCIINTT TIEPYYLATT VVPGLLLG-H HTQKKCGGGG PPPPPPLLAK ---PREEEYY YCCCCIINTT TIEPYYLATT ---------- ---------- ---------K ---PREEEYY YCCCCIINTT TIEPYYLATT ---------M MTKNNCGGGG PPPPSSLLAK ---PREEEYY YCCCCIINTT TTEPYYLATT TTVPRRRIAT TTKNNCGGGG PPPPSSLLAK ---PREEEYY YCCCCIINTT TTEPYYLATT ---------M MTKNNCGGGG PPPPSSLLAK ---------- ---------- -TEPYYLATT ---------M MTKNNCGGGG PPPPSSLLAK ---PREEEYY YCCCCIINTT TTEPYYLATT AAFGLLLQET TTKDDCGGGG PPPPPPQQAK ---PREEEYY YCCCCIINTT TTEPYYLATT TTLYTTTVFS STKNNCGGGG PPPPSSLLAK ---PREEEYY YCCCCIINTT TTEPYYLATT ---------M MTKNNCGGGG PPPPSSLLAK ---PREEEYY YCCCCIINTT TTEPYYLATT IIAVTTTAAN NKTHHKGGGG PPPPAALLAE KKKPREEKYY YCCCCVVGTT TINLYYLATT ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AKSSCGGGG PPPPKKLLAK ---PREEEYY YCCCCIISTT TINPYYLATT --VHVVVNEK K-VCCSGGGG PPPPAAIISS ---PREESYY YAAAAVVGTT TIEPYYLATT --VHVVVSEV VNQCCSGGGG PPPPAALLAS ---PREETYY YAAAAVVGTT TIEPYYLATT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---LLGGGGG PPPPAALLAS ---PSEEKYY YAAAAVVGTT TIDPYYLATT ----MMMAAN NAAGGTGGGG PPPPAALLAE KKKPREEKYY YCCCCVVGTT TINPYYLGTT -------SPC CLKGG-GGGG PPPPAAAAAK ---PREEEFF FAAAAPP-NN NADPAAIFTT -------P-C CLKGG-GGGG PPPPAAAAAK ---PREEEFF FAAAAPP-HH HRDPAAIFTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MSKKCGGGG PPPPAALLAR NNNPVEEKYY YCCCCVVNLL LEEGYYLATT ---------- ---------- ---------R SSSPREEKYY YTTTTVVNLL LEPGYYLSTT ---------- ------MMMM PPPPII--II SSSDDRRFFF FWWWWLLDII IQYIDDRKNN ---AAAAG-L LMGFFFAAAA DDDDCCPPMK IIIGQEEEYY YTTTTLLEGG GGDQKKLVTT SSAAVVVGLL LLAAARAAAA DDDDCCPPMK IIIGQEEDYY YTTTTLLEGG GGDQKKLVTT VVVDDVKSEE ETYYKHKKVV VEPYIIIIID ELHHHHGGGG WNSS--PGGG --PPNNRFFL VVVDDVKSPP PTYYKYKKLL LDPYIIIIID ELHHHHGGGG WNSS--PAAA --PPFFRYYL VIIDDVGSSS STYYKHTTVV VTPNTTTTTD EFHHHHGGGG WNSS--PTTT GGAAFFRFFL VIIDDVGSPP PTYYQHTTVV VTPNKKKKKD EFHHHHGGGG WNSS--PAAA GGAAFFRYYL VVVDDVTSEE EKFFQHQQLL LIPNKKKKKD EFHHHHGGGG WNSS--PTTT GGAAFFRYYL VVVDDVASPP PRYYSGQQVV VAPHAAAAAD ELHHHHGGGG WNSS--PAAA PPPPHHRYYL VVVDDVQSSS STFFQGVVTT TDPYTTTTTG ELHHHHGGGG WNSS--PAAA PPPPHHRYYL VLLDDLDSGG GTYYQGRRVV VEPNAAAAAD ELHHHHGGGG WNAA--PAAA PPPPHHRYYL TVVDDVKSPP PQYYQHRRLL LPPYLLLLLD ELHHHHGGGG WNSS---FFF GGSSTTNKKL TVVDDVKSPP PHYYQHRRLL LPPHLLLLLD ELHHHHGGGG WNSS---FFF GGSSTTDKKL TVVDDIKSPP PQYYQHRRLL LPPNLLLLLD ELHHHHGGGG WNSS---FFF GGSSTTTKKL TVVDDVKSPP PQYYQHRRLL LPPHLLLLLD ELHHHHGGGG WNSS---YYY GGIITTTKKL TVVDDVKSPP PQYYQHRRLL LPPNLLLLLD ELHHHHGGGG WNSS---FFF GGSSTTTKKL TVVDDVKSPP PQYYQE---- ---------- ---------- ---------- ---------- TVVDDVKSPP PQYYQHRRLL LPPNLLLLLD ELHHHHGGGG WNSS---FFF GGSSTTTKKL TVVDDVKSPP PQYYQHRRLL LPPNLLLLLD ELHHHHGGGG WNSS---FFF GGSSTTTKKL TVVDDVKSPP PQYYQHRRLL LPPYLLLLLD ELHHHHGGGG WNSS---FFF GGSSTTNKKL TVVDDVKSPP PQYYQHRRLL LPPNLLLLLD ELHHHHGGGG WNSS---FFF GGSSTTTKKL TVVDDVKSPP PQYYQHRRLL LPPNLLLLLD ELHHHHGGGG WNSS---FFF GGSSTTTKKL TVVDDLSSPP PTYYQHRRLL LPIHIIIIID KLHHHHGGGG WNSS---HHH GGPPSSRFFL ---------- ---------- --PNTTTTTD ELHHHHGGGG WNSS---YYY GGAASSNKKL TVVDDVKSPP PSYYQHRRLL LPPNVVVVVD ELHHHHGGGG WNSS---YYY GGSSSSNKKL TVVDDVSSPP PTYYKHRRLL LPPYVVVVVD ELHHHHGGGG WNSS---HHH GGPPSSRFFL TVVDDLNSPP PTYYKHRRLL LPPYVVVVVD ELHHHHGGGG WNSS---HHH GGPPSSRFFL ---------- ---------- --PFVVVVVD ELHHHHGGGG WNSS---HHH GGAASSRYYL TVVDDVSSPP PSYYSHRRLL LPPFVVVVVD ELHHHHGGGG WNSS---HHH GGAASSRYYL TVVDDVNSPP PTYYQHRRLL LPTHVVVVVD ELHHHHGGGG WNSS---HHH GGPPSSRFFL TVVDDVESDD DTFFQSRRVV VDPHIIIIID EVHHHHGGGG WNSS---HHH DDPPTTSHHL TVVNNVESEE ETFFQSRRVV VDPNIIIIID EVHHHHGGGG WNSS---HHH DDPPTTSHHL ---------- ---------- ---------- ---------- ---------- ---------M TVVDDVASPP PTYYQHRRTT TYNSKKKKKN ELHHHHGGGG WNSSVVPGGG GGEEVVDRRL TVVDDVESPP PTYYQHRRTT TFNRKKKKKD ELHHHHGGGG WNSSVVDSSS SSTTVVDRRL NPPRRMQVFF FLGGSKDDGG GPKVLLLLLD KELLLDQQQQ PTLL------ GGRRVVPQQM TIIDDLGSAA ATRRQNSSVV VSGG-----N EAHHHHGGGG FS-------- ------RFFF TVVDDAKSPP PQYYKNTTLL LSGG-----N EAHHHHDDDD FT-------- ------RYYL VPPGGLRRRS SRRIIIYYII TKKNPPREPK IKVIEPEEKK SGSSRLHTCG DDISSSSAAA VPPAALRRRS SRRIIIYYIV TKKDKKRRPA VKIVEPEVVV TGTTKYHTCG DDISSSSAAA IPPGGLRRRS SRRIIIYYVI TKKHPPTQAR IKIIEPDELL TGSSRPHTCG EEVSSSSTTT IPPGGLRRRS SRRIIIYYII TKKDPPTKAK IKIIEPEEFF TGSSRPHTCG DDVSSSSTTT IPPGGIRRRS SRRIIIYYIV VKKEPPLKAK IKIIEPEEFF TGSSRPHTCG EEVSSSSTTT VPPGGLRRRS SRRIIIYYIL TKKDPPLKPF LKVIEPETAA TGSSRPHTCG GGVTTTTAAA VPPDDIRRRS SHHIIITTIL TKKDPPTQPK VKVIDPNEAA TGAARPHTCG DDISSSSAAA VPPGGIRRRS SRRIIIHHIV TKKDPPREPR IKVIEPEEHH TGSSRPHTCG DDVSSSSAAA LPPGGLMMMS SRRIIIYYVV VGGEPPRAPK LKVIEASEQQ CNSSNTHTCL SSMVVVVNNN LPPSSIIIIS SRRIIIYYVV VGGEPPRAPK LKVIEPNEHH CNGGNLHTCL SSMIIIISSS LPPCCLMMMS SRRIIIYYVV VGGDPPRAPK LKVIEAEDHH CGGGYVHTCL SSMIIIISSS LPPAALIIIS SRRIIIYYVV VGGEPPRAPK LKVIEPKDHH CNGGFFHTCL SSMVVVVSSS LPPSSLIIIS SRRIIIYYVV VGGEPPRAPK LKVIEPEDHH CEAAFLHTCL SSMIIIISSS ---------- ---------- ---------- -----PKDHH CEAAFLHTCL SSMIIIISSS LPPSSLIIIS SRRIIIYYVV VGGEPPRAPK LKVIEPKDHH CEAAFLHTCL SSMIIIISSS LPPSSLIIIS SRRIIIYYVV VGGEPPRAPK LKVIEPKDHH CEAAFLHTCL SSMIIIISSS LPPSSFIIIS SRRIIIYYVV VGGEPPRAPK LKVIEAKDHH CGGGTPHTCL TTMIIIISSS LPPSSL---- ---------- ---------- ---------- ---------- ---------- LPPSSLIIIS SRRIIIYYVV VGGEPPRAPK LKVIEPKDHH CEAAFLHTCL SSMIIIISSS LPPSSLLLLS GRRVVVYYVV TAADPPRTPS LKVVESEDAA IGGGFPHTCL SSMIIIISSS LPPCCLIIIS SRRIIIYYVV VGGDPPRAPR IKTVEPYEFF CGAANLHTCL CCMIIIISSS LPPCCLIIIS SRRIIIYYVV VGGDPPRAPR IKTVEPYEFF CGAANPHTCL CCMIIIISSS APPSSLVVVS GRRIIIYYVI TKKNPPRSPS LKVVDPADII TGAAYPHTCL SSMIIIISSS VPPGGIVVVS GRRVVVYYVI TKKNPPRAPS LKVVEPEDSS TGAAYPHTCL SSMIIIISSS LPPSSLIIIS GRRIIIYYAI TKKNPPRAPS LKYVDPKEAA TGAAYPHTCL SSLVVVVSSS LPPSSLIIIS GRRIIIYYAI TKKNPPRAPS LKYVDPKEAA TGAAFPHTCR --LVVVVSSS LPPSSLLLLS GRRVVVYYVV TLLDPPRAPA LKVVEAEDAA TGGGFPHTCL SSMIIIISSS VPPCCLNNNS DRRIIIYYII VEEE--RKIY LHTIEPSKHH N-SSFPHTCL DDMIIIISSS VPPCCLNNNS DRRIIIYYVI VEEE--REIY LHTIEPSKHH N-SSFPHTCL DDMIIIISSS PRRKKLSSSS GVVEEEGGKV VGG------- ---------- ---------- ---------- LPPCCLNNNS DRRIIIFFVI TGGDPPRAPK LKVIEG-DLL ADTTAPHTCL NNMIIIISSS LPPSSLNNNS DFFIIIYYIL VVVDPPRKPE IKTIDG-DLL HNTTAPHTCL NNMIIIISSS QLLSSLDDDG KRRLLLYYVT SLLSAAWDKQ FP-----DII LVAAISHTYQ NNKQQQQDDD TGGGGLDDDT NRRIIIFFIF VHHDPPSNPK LKTIDT-FKK GGVVGPHTAL GGITTTTGGG AGGGGLDDDT SKKIIIFFVF VHHDPPARPV LKTITD-FEE GGVVGPHTAL GGITTTTGGG LLGGNE---- GGGILMMLYE EPPLLGGGKK WIIIDQQ--- ---------L LYDDDWWWWN LLGGGP--RR GGGIFLLLDE EPPIIGGGRR WVVVPQQ--- ---------F FYDDDWWWWN LLGGGAKKTT GPGIFIIMED DVVLLGGGRR WIIIPQQ--- ---------K KYDDDWWWWN LLGGGGKKTT GPGVFIIMEE EVVLLGGGRR WIIIPQQ--- ---------L LYDDDWWWWN LLGGGGEETT GPGIFIILEE EIILLGGGRR YMMMEQQ--- ---------K KYDDDWWWWN LLGGNA---- GGGIAMMLQE EPPLLGGGRR WVVVPQQ--- ---------F FYDDDWWWWH LLGGSP---- GGGIFIILDE EVVLLGGGRR WIIIDQQ--- ---------L LYDDDWWWWH LLGGSP---- GGGVFVVMED DPPLLGGGRR WVVVPQQ--- ---------L LYDDDWWWWH TTLLGD--GG GGSFVLLLEE EVVKKGGGTT WKKKASS--- ---------M MYDDDWYYYQ SSLLGD--GG GGGFVLLLEE EVVKKGGGTT WKKKEAA--- ---------M MYDDDWYYYQ TTLLGD--GG GGGFVLLLEE EVVKKGGGTT WQQQAAA--- ---------M MYDDDWYYYQ TTLLGD--GG GGGFVLLLKE EVVKKGGGTT WQQQAAA--- ---------L LYDDDWYYYQ SSLLGD--GG GGGFVLLLEE EVVKKGGGTT WRRRAAA--- ---------S SYDDDWYYYQ SSLLGD--GG GGGFVLLLEE EVVKKGGGTT WRRRAAA--- ---------L LYDDDWYYYQ SSLLGD--GG GGGFVLLLEE EVVKKGGGTT WRRRAAA--- ---------L LYDDDWYYYQ SSLLGD--GG GGGFVLLLEE EVVKKGGGTT WRRRAAA--- ---------L LYDDDWYYYQ TTLLGD--GG GGGFVLLLEE EVVKKGGGTT WRRRSAA--- ---------M MYDDDWYYYQ ---------- ---------- ---------- ---------- ---------- ---------- SSLLGD--GG GDGSLVVL-E ECCSSGGG-- ---------- ---------- ---------- CCLLGD--GG AGNGFLLLSN NVVKKGGGRR GNNNPII--- ---------K KRTTTLYYYE SSIIGD--GG GGGFVLLLEE EVVKKGGGNN WAAAAAA--- ---------F FYDDDWYYYQ SSLLGD--GG GGGFVLLLEE EVVKKGGGNN WVVVSAA--- ---------F FYDDDWYYYQ CCLLGD--GG AGNGFLLLSN NVVKKGGGRR WKKKSPP--- ---------F FYDDDWYYYQ CCIIGD--GG AGNGFLLLSN NVVKKGGGRR WKKKSPP--- ---------F FYDDDWYYYQ CCLLGD--GG AGNGFLLLSN NIIKKNNNRR WKKKSPP--- ---------F FYDDDWYYYQ CCLLGD--GG AGNGLLLLSN NIIKKNNNRR WKKKSPP--- ---------Y YYHHHWYYYQ CCLLGD--GG AGNGFLLLSN NVVKKGGGRR WKKKSPP--- ---------F FYDDDWYYYQ TTLLGE--GG PGNFLLLLKE EPPKKGGGTT WAAATVV--- ---------F FYDDDWYYYQ TTLLGE--GG PGNFLLLLKE EPPKKGGGTT WAAAVVV--- ---------F FYDDDWYYYQ ---------- ---------- ---------- ---------- ---------- ---------- IIMMGD--GG AG-DFVVEKE ELLVVGGGTT WRRRKAA--- ---------C CYDDDWYYYQ VVMMGD--GG AG-DFIILSN NCCIIGGGTT WKKKKAA--- ---------C CYDDDWYYYQ GGVVNE--SS PLNGIQQTHG GLLSSAAAKK GAAAEEE--- ---------L LLSSSHNNNN LLSSND--HH GTALVEEYDY YVVAATTTYY WPPPDMMGVV AVGAAAVVAY YYDDDRAAAL LLSSNN--HH GTALVEEYAY YVVAATTTHH WPPPDLLGII KTGKKKYYAY YYDDDRAAAL LVLSSWAAVP P----DDGGE EKDD--YYYN NIHHHFFLLR RRRRILGEEN NNRRRRMAAA LVMSSWTTVP P----EEGGE EKEEGGYYYN NLHHHVVLLA RRRHLIGEEH HHRRRRMVVV LYMSSWAALP P----NNGGE ELAANNYYYH HLHHHFFLLR RRRNVIGQQH HHQQQQMAAA LYMSSWAALP P----NNGGE ELSSNNYYYH HLHHHFFLLR RRRNVIGNNH HHQQQQMAAA LYMSSWGGLP P----NNGGE ELSSNNYYYH HIHHHFFLLR RRRNVIGNNH HHQQQQMAAA LTLSSWGGTP P----DDGGD DLGGAAYYYR RLHHHFFLLT RRRHLIGEEH HHQQQQLVVV LTLSSWGGTP P----SSGGD DLAAGGYYYH HLHHHVVLLY RRRHLLGEEY YYQQQQMAAA LTMSSWGGTP P----GGGGQ QLNNKKYYYR RLHHHIILLR RRRHLLGEEH HHQQQQMVVV PVMTTWAAAP P----DDGGH HA--GGYYYS SIFFFVVWWQ HHHIILT--D DDGGGGLIII PIMTTWAAAP P----DDGGH HA--GGYYYS SIHHHVVWWQ HHHIILK--D DDGGGGLIII PVMTTWAAAP P----DDGGD DA--GGYYYS SLHHHVVWWQ HHHIILQ--D DDGGGGLIII PVMTTWAAAP P----DDGGD DA--GGYYYS SLYYYVVWWQ RRRIVLQ--D DDGGGGLIII PVMTTWAAAP P----DDGGD DA--GGYYYS SLYYYVVWWQ HHHIVLK--D DDGGGGLIII PVMTTWAAAP P----DDGGD DA--GGYYYS SLYYYVVWWQ HHHIVLK--D DDGGGGLIII PVMTTWAAAP P----DDGGD DA--GGYYYS SLYYYVVWWQ HHHIVLK--D DDGGGGLIII PVMTTWAAAP P----DDGGD DA--GGYYYS SLYYYVVWWQ HHHIVLK--D DDGGGGLIII PVMTTWAAAP P----NNGGD DA--GGYYYK KLHHHVVWWQ HHHIVLP--D DDGGGGHIII ---------- ---------- ---------- ---------- ---------- ---------- ---AASAAHS S----TTGGP PA--SSVVVG GT-------- ---------- ---------- NLFWWQCCCS S----TTGGC CA--SSVVVV VSCCCLLYYI RRRIDLQ--D DDQQQQAGGG PVMTTWGGAP P----LLGGE EA--GGYYYH HLNNNVVWWT HHHRIIG--D DDGGGGLIII PVMTTWGGAP P----LLGGD DA--GGYYYH HLNNNVVWWT HHHLVIG--D DDGGGGLIII PTMTTWGGAP P----KKGGH HD--GGYYYR RLTTTCCLLA GGGLRLG--T TTGGGGLLLL PTMTTWGGAP P----QQGGH HD--GGYYYR RLHHHVVWWP GGGIKLG--K KKGGGGLLLL PTMTTWGGAP P----KKGGH HD--GGYYYS SLHHHVVWWP GGGMKIG--T TTGGGGLLLL PTMTTWGGAP P----KKGGH HD--GGYYYS SLHHHVVWWP GGGIKIG--T TTGGGGLLLL PTMSSWGGAP P----TTGGH HD--GGYYYR RLHHHVVWWP GGGLKLG--T TTGGGGLLLL PVMTTWGGSP P----KKGGH HE--GGYYYN NVHHHIIWWD KKKYLIPPPL LLGGGGALLL PIMTTWGGSP P----KKGGH HE--GGYYYN NVHHHIIWWD KKKHLIPPPR RRGGGGALLL ---IIRGGGP P----RRDDC CE--PPVVVK KKRRRVV--- ---------- ---------- PVMSSWGGAP P----RRGGD DDRRTTYYYC CLNNNFFWWQ RRRLFIG--D DDGGGGLTTT PVMSSWGGAP P----RRGGD DDMMSSYYYC CLNNNFFWWS QQQLYIG--D DDGGGGITTT GKSDDPDDEP P----EESSL LTGGPPKKKQ QVAAAEE--- ---------- ---------- IVMSSFTTGW WNNNNFFGGD DAMMKKFFFN NIVVVQQLLH RRRPKFPAAP PP-------- PLLSSFTTGW WNNNNFFGGD DAMMKKFFFN NVVVVTTLLH KKKPKFPAAP PP-------- L--------- ERLLHPPTLM MGGGGFIMVK DDDLSSSSSL WWWYYDDDDG GGWNVVIIII L--------- ERLLHPPTLM MGGGGFVVLK DDDLSSSSSL WWWYYDDDDG GGWQVVIIII L--------- ERAAHPPVEY YGGGGFVVVT NNNLEEGGST WWWRRGGGGG GGFHTTAAAA L--------- ERAAHPPVEY YGGGGFVVVT NNNLEEAAST WWWRRGGGGG GGFHTTAAAA L--------- ERAAHPPSDY YGGGGFCVVT NNNLQQGGAT WWWQQDDDDG GGFETTIIII F--------- ERAAHPPTAY YGGGGFVCIK DDDLSSSSST WWWRRKKKKD DDWAVVIIII L--------- ERAAHPPTAY YGGGGFMCVK DDDLSSAASL WWWRRNNNNG GGWHVVIIII L--------- ERAAHPPATY YGGGGFVVVE DDDLSSAASL WWWRRNNNNG GGWGVVIIII P--------L ERLLHPPSTQ QGGGGFVCLN IIIQRRFFYE EEE------- ------TTTT P--------L ERLLHPPDTQ QGGGGFVCLN IIIQRRFFYE GGG------- ------TTTT P--------L ERLLHPPDAQ QGGGGFVCLT IIIQRRFFYQ GGG------- ------TTTT P--------L ERLLHPPDAQ QGGGGFVCLT IIIQRRFFFE DDD------- ------TTTT P--------L ERLLHPPDAQ QGGGGFVCLT IIIQRRFFYE GGG------- ------TTTT P--------L ERLLHPPDAQ QGGGGFVCLT IIIQRRFFYE GGG------- ------TTTT P--------L ERLLHPPDAQ QGGGGFVCLT IIIQRRFFYE GGG------- ------TTTT P--------L ERLLHPPDAQ QGGGGFVCLT IIIQRRFFYE GGG------- ------TTTT P--------L ERLLHPPASQ QGGGGFVCLT IIIQRRFFYE GGG------- ------TTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ANNPIIIIIL CRIIHKKNNQ QDDDDYDVVS GGGRGGGGSD AAA------- ------AAAA P--------L ERLLHPPDAQ QGGGGLVCLT VVVFRRFFYK DDD------- ------KKKK P--------L ERLLHPPDDQ QGGGGLVCLS IIIFRRFFYK DDD------- ------KKKK P--------L ERLLHPPADT TGGGGFVSLN MMMIRRFFFQ DDD------- ------SSSS P--------L ERLLHPPADT TGGGGFVSLN MMMIRRFFFQ DDD------- ------SSSS P--------L ERLLHPPSDT TGGGGYVSLN MMMIRRFFFS DDD------- ------TTTT P--------L ERLLHPPSDT TGGGGFVSLN MMMIRRFFFS DDD------- ------TTTT P--------L ERLLHPPSDT TGGGGYVCLN MMMVRRFFFA DDD------- ------SSSS P--------L ERLLHPPTEH HAAAAFVCLG IIIFRRIIHE EEESS----- ------TTTT P--------L ERLLHPPTEH HAAAAFVCLA IIIFRRIIHE KKKPP----- ------VVVV ---------- ---------- ---------- ---------- ---------- ---------- P--------L ERLLHPPRNQ QGGGGYVCFX XXXXXXXXX- ---------- ---------- P--------L ERLLHPPKAE EGGGGFVCLK VVVFHHFFKS DDDDD----- ----FFEEEE ---------- ---------- ---------- ---------- ---------- ---------- ---------L ERPPWSSNNY YAAAAFSTLQ LLLWLLIIYD AAA------- ---------- ---------L ERAAWEEANY YCCCCFTTLQ LLLWLLIIYG EEE------- ---------- IAEPPPLLLE -LPPEFFAVV PPLLTTDDDD LDKFYLSSWW GIDDPFFKPV KKKIFFFHAD IAQPPPFFFE -LPPPFFMVV PPLLTTDDDD LDRFYVSSWW GLDDPHHQPR RKKLYYYHEP IAEPPPAAAT DLPPPFFAVV PPLLTTDDDD LDRFYVSSWW GTDDPHHNPV SRRIAAARAP IPEPPPAAAP ELPPPFFAVV PPLLTTDDDD MDRFYVSSWW GTDDPRRKPK SHHIAAARTP IPVPPPAAAD DLPPDFFACC PPLLTTDDDD LDKYYVAAWW GLDDPMMNPV KEEIVVVKTP IAEAAAAAAD DLPPPFFAVV PPLLTTDDDD MDRFYVSSWW GTDDPFFEPK KRRIVVVSAT IAEPPPAAAS DLPPPFFAVV PPLLTTDDNN VDRFYVSSWW GTDDPFFNPR KQQIVVVRAG IAEPPPAAAE DLPPPFFAVV PPLLTTDDNN LDRFYVSSWW GTDDPFFNPR SRRIVVVRAA SEKVVVIIIQ PKKKVLLEMM PGLLTTDDLL LDRFYFSSWW LHDDPQQKPR QFFSIIIVGG SEKVVVIIIQ PKKKVLLEMM PGLLTTDDLL LDRFYFSSWW LHDDPKKKPR QFFSIIIVGG SEKVVVIIIQ PKKKVLLEMM PGLLTTDDLL LDRFYFSSWW LHDDPQQRPR QFFSIIIVGG SQKVVVIIIQ PKKKVLLEMM PGLLTTDDLL LDHFYFSSWW LHDDPQQRPR QFFSIIIVDG SEKVVVIIIQ PKKKVLLEMM PGLLTTDDLL LDRFYFSSWW LHDDPQQRPR QFFSIIIVGG SEKVVVIIIQ PKKKVLLEMM PGLLTTDDLL LDRFYFSSWW LHDDPQQRPR ---------- SEKVVVIIIQ PKKKVLLEMM PGLLTT---- ---------- ---------- ---------- SEKVVVIIIQ PKKKVLLEMM PGLLTTDDLL LDRFYFSSWW LHDDPQQRPR QFFSIIIVGG SEKVVVIIIE PKKKVLLEMM PGLLTTDDLL LDRFYFNNWW LHDDPKKRPR QFFSIIIVGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VKRKKKLLLD YAVVVVVSLL SNEEPPPPWW FDLLIFLL-- ---------- ---------- AEKVVVIIIK PKKKVLLEMM PGLLTTDDLL LDRFYFSSWW LHDDPRRNPK QFFSIIILGG AEKVVVIIIQ PKKKVMMEMM PGLLTTDDLL LDRFYFSSWW LHDDTRRNPK QFFSIIIQGG SELAAAIIIP KLKKVLLEMM PGLLTTDDLL LDRFYFVVWW LHNNLKKNPV QWWLIIIQGS NEIVVVIIIS ELKKVLLEMM PGLLTTDDLL LDRFYFVVWW LHNNVKKNPK QWWLIIIQGS SEIVVVIIIS KLKKVLLEMM PGLLTTDDLL LDRFYFVVWW LHNNPKKNPV QWWLLLLQGS SEVVVVIIIS KLKKVLLEMM PGLLTTDDLL LDRFYFVVWW LHNNPKKNPV QWWLLLLQGS SEVAAAIIIS KLKKVLLEMM PGLLTTDDVV LDRYYLVVWW LHNNPAAKPV QWWLLLLQGS ATLVVVAAAF PKKKVLLEMM PALLTTDDLL MDRFYVSSWW LHDDPLLKVK QYYSVVVHES TSLVVVAAAT PKKKVLLDMM PALLTTDDLL MDRFYVSSWW LHDDPKKNPK QFFSIIIHET ---------- ---------- ---------- ---------- ---------- ---------- ---------- --QQGIIMMM GGMMTTDDLL LDRYYFSSWW RHDDRAANPR QFFAIIIQDA KVIDDDIIIP KVDDTAADMM GGMMSSDDII LDRFYVNNWW RHDDPEENPK QFFAIIICDL ---------- ---------- ---------- ---------- ---------- ---------- ---------E QKAAVNNADD IPLLVVDDSS ADQTWINNFF MDDDPHHKPF EVVQVVVN-- ---------E QKAAVEEAKK VPLLVVDDSS NDSRWVNNFF MDDDPHHHPR ETTQVVVN-- HHP------- --------GG HGAMLLEIIG GRVTNNSLSS STTNNQFFYP EEGKKKKGGG HHP------- --------GG AGAMIISVVG GRITNNSLSS SSSNNQFFYP --GRRRRGGG HHP------- --------GG RGGMVVEIIG GRWTNNSLSS STTDDQFFYP DDGPPPPAAA HHP------- --------GG KAGMVVEIIG GRWTNNSLSS STTDDQFFYP DDGPPPPGGG HHP------- --------GG KYGMVVEIIG GKWTNNSLSS STTEEQFFYP GGDGGGGAAA HHPGG----- -------ANN GGGMVVEIIG GRFTNNSLGG GAAPPQFFYP EEGDDDDGGG HHP------- -------ASS AGGMVVEIIG GRFTNNSLRR RAAEEQFFYP DDGKKKKGGG HHP------- --------SS GGGMVVEVVG GRFSNNSLAA ASSEEQFFYP VVGRRRRGGG SSVQQVL-QQ ELLEPPLVGG KGGMIIQLLG GKATTTSLSS SDDKKQFFY- PPDIIIIRRR SSVQQVL-QQ ELLEPPLVGG KGGMIIQLLG GKVTTTSLSS SAAKKQFFY- PPNIIIIRRR PPVQQVL-QQ ELLEPPLVGG KGGMIIQLLG GKVTTTSLSS SAAKKQFFY- PPDIIIIRRR PPVQQVL-QQ ELLEPPLVGG KGGMIIQLLG GKVTTTSLSS SAAKKQFFY- PPDIIIIRRR PPVQQVL-QQ ELLEPPLVGG KGGMIIQLLG GKITTTSLSS SAAKKQFFY- PPDIIIIRRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPVQQVL-EE ELLEPPLVGG KGGMIIQLLG GKITTTSLSS SAAKKQFFY- PPDIIIIRRR PPVQQVL-QQ ELLEPPLVGG KGGMIIQLLG GKVTTTSLSS SDDKKQFFY- PPDIIIIRRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPVTTVL-KK DLLDPPVVGG KGGMIIQLLG GKVTNNSLSS SKKKKQFFY- PPDIIIIKKK PPVTTVL-KK ELLDPPVVGG KGGMIIQLLG GKVTSSSLSS SIIKKQFFY- PPDLLLLKKK PPVAAAI-DD GKKDVVPIGG QGGMIIQLLG GKVTNNSLSS SAAKKQFFY- PPGVVVVEEE PPVVVAV-DD GEEDVVPIGG KGGMIIQLLG GKVTNNSLSS SAAKKQFFY- PPKVVVVEEE PPVKKAV-DD GNNDVVPIGG KGGMIIQLLG GKATNNSLSS SAARRQFFY- PPEMMMMDDD PPVKKAV-DD GNNEVVPIGG KGGMIIQLLG GKATNNSLSS SAAVVSFFY- PPEMMMMEEE EEVVVYV-DD DKKSVVPVGG HGGMIIQLLG GKVTNNSLSS SRREEQFFYG QQDVVVVKKK NNVKKVL-EE K--EAALVGG RGGMLLQLLG GKVTTTSLKK KKKDDQFFY- PPEVVVVKKK TTVKKVL-DD HDDPAALVGG RGGMLLQLLG GKVSTTSLKK KKKDDQFFY- PPEVVVVRRR ---------- ---------- -GGKIIQLLG GKVTNNSFSS STTKKQFFY- PPNVVVVKKK PPRRRVL-PP ELLEPPVLGG RGGMLLQLLG GRVSSSSLSS SPPKKQFFY- PPEVVVVAAA PPNVVIVEKK ELLPAARVGG RGGMLLQLLG GKVSSSSLSS SPPKKQFFY- PPKVVVVSSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MVVSQQG GKFSSSSLAA ANN------- -------KKK ---------- ---------- ---MVVSSSG GQYTSSSLAA ANN------- -------KKK GVAN-----P SSGGEIIDKK EDDF------ -SSHQQQQQV VSGGGGDDDA SDYCYP---- GAVN-----P EEGGELLEKK EDDF------ -AAHQQQQQV VWGGGGDDDA SDFCYP---- AVAG-----P DDGGTLLADD DEEFG----- -AAHQQQQQI IEGGGGDDDC SDFCYPSSVV GVVG-----G NNGGELLDKK DSSFG----- -AAHQQQQQI IEGGGGDDDC SDFCYPSSVV AVVG-----E NNGGTLLDKK DDDFG----- -SSHQQQQQI IEGGGGDDDC SDFCYPSSVV GVAG-----P NNGGEFFDPP KEEWG----- -PPHQQQQQV VQGGGGDDDC SDYCYP---- GVVN-----P DDGGQFFDPP NDDF------ -VVHQQQQQI IQGGGGDDDA SDYCFP---- GAAD-----P GGGGSLLDPP GEEVG----- -PPHQQQQQI IEGGGGDDDS SDYCYPSS-- RSQVDDVDTV NNGGKLLNPP NDDFELLLGG PAAHEEEEEL LPGGGGDDDC SDWI------ RSQIDDVDTA NNGGKLLNPP NDDFELLLGG PAAHEEEEEL LPGGGGDDDC SDWI------ RSQIDDVDTV KKGGKLLNPP NDDFELLLGG PAAHEEEEEL LPGGGGDDDC SDWL------ RSQIDDVDTV KKGGTLLNPP NDDFELLLGG PAAHEEEEEL LPGGGGDDDC SDWL------ RSQVDDVDTV KKGGKLLNPP NDDFELLLGG PAAHEEEEEL LPGGGGDDDC SDWI------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RSQVDDVDTV KKGGKLLNPP NDDFELLLGG PAAHEEEEEL LPGGGGDDDC SDWI------ RSQIDDVDTV KKGGKLLNPP NDDFELLLGG PAAHEEEEEI IPGGGGDDDC TDWL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KSQIDDVDTE KKGGKLLNPP NDDFEGGGGG PAAHEEEEEL LPGGGGDDDC SDWV------ KAQIDDVDTK KKGGKLLNPP NDDFEDDDGG PAAHEEEEEI IPGGGGDDDC TDWI------ ESQIDDVDTE KKGGKIINPP NDDFEDDDGG PAAHEEEEEM MPGGGGDDDC TDWI------ ESQIDDVDTE NNGGKIINPP NDDFEDDDGG PAAHEEEEEM MPGGGGDDDC TDWI------ DSQIDDVDTE KKGGSIINPP NDDFEEEEGG PAAHEEEEEM MPGGGGDDDC TDWI------ ESQIDDGDTE KKGGTIINPP DDDFEDDDGG PAAHEEEEEM MPGGGGDDDC TDWI------ KSQIDDVDTE KKGGSIINPP NDDFEEEEGG PAAHEEEEEM MPGGGGDDDC TDWI------ KAQVNNIDPE SSKKEIINRR DDDFIGGGGG PAAHEEEEEM MPGGGGDDDC TDWI------ RAQIDDVDPI TTHHVIINKK NDDFVGGGGG PAAHEEEEEM MPGGGGDDDC TDWI------ KSQIDDVDTE KKGGTVVNKK NDDFENNNGG PAAHDDDDDI IPCCCCDDDS TDLA------ AGQLDDIDVE NNGGKLLNEE NDDFEYYYGG PPPHEEEEEM M--------- ---------- SGLIDDVDTV NNGGSLLNEE DDDFEYYYGG PPPHEEEEEM MPGGGGDDDC TDWLANDDAA ---------- ---------- ---------- ---------- ---------- ---------- KKQYLLKAYN WWGGELLVEE DDDFLLLLGG -AAHIIIIIM MGSSSSAAAL YS-------- KKQFLLKLYY WWGGELLKEE QDDFELLLGG -PPHQQQQQM MGAAAAAAAL YGAGDGNNRR ------- ------- KKR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LLVQARE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NNAKKKKAKK KKKQPSERRR TVVPPPPPGG LTTAARRRAD DDAAMMLPPT TTTAALLSSS gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TPPVRRKKAY YYQEAAWTTF FSSSSAIQQL SSSSSPRSSK RRKKTVLLLV EIIISAAVAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M MMAGRSAPPT TLPPPPLNNR PPPPTPHPPL PPAASHVVVP LTTTLVVRPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MVF KKKRDTYSSS ---------- ---------- ---------- ---------- --------AL KKKPDTYTTT ---------- ---------- ---------- ---------- --------MM RRRPDTHSSS ---------- ---------- ---------- ---------- --------MM RRRPDTHSSS ---------- ---------- ---------- ---------- --------ML RRRPDTYSSS ---------- ---------- ---------- ---------- --------AW KKKPDSYSSS ---------- ---------- ---------- ---------- --------VW RRRPDTYSSS ---------- ---------- ---------- ---------- --------AW RRRPDTYSSS ---------- ---------- ---------- ---------- ------ATT- ---CGGPPPP ---------- ---------- ---------- ---------- ---------- ---------- KKQVVSQAAA AAAAAVQQHH HWWLLPPGKH GAAALLAAPP RGGPG-STG- ---CGGPPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------ATG- ---CGGSPPP ---------- ---------- -----AARAE GAAFLLSSVV QPPPIAATG- ---CGGSPPP ---------- ---------- ---------- ---------- ------ATG- ---CGGSPPP ---------- ---------- ---------- ---------- ------ATG- ---CGGSPPP ---------- --------MM MGGLLGGEEP GHHTQQWWFF SGGWQEATG- ---CGGPPPP ---------- --------KK KNNSSQQCLG FDDQNNEELL TYYLVFPTG- ---CGGSPPP ---------- ---------- ---------- ---------- ------ATG- ---CGGSPPP YYRTTVPPPP PPPPPLPPPP PHHAARRSLV LQQHMMGGAA AVVAAAGKCT AAAKGGAPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MAG- ---CGGKPPP ---------- ---------- ---------- ----MMTTVV DHHVNES-GC KKKSGGAPPP ---------- ---------- ---------- ----MMTTVV QHHVSENNGC KKKSGGAPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MQ VVVGGGAPPP ---------- ---------- ---------- ---------- ---AAAGACG AAATGGAPPP ---------- ---------- ---------- ---------- ---MSPGLH- ----GGAPPP ---------- ---------- ---------- ---------- ---MP-PLH- ----GGAPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MSC KKKCGGAPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MGI--- ---------- ---------- ---MMKKREF G--------- -AAAG-AMPR AAAFAECSSS ---------- ---------- ---MMKKFIV SGGPMMFFAA RAASGLALPG VVVRAECSSS PPPPKKKAAA KPPPEEDDLA YACYYTGTGG GGINDFIIAN NPPPKKKKSE EESHHKELLP PPPPRRRAAA RPPPEEDDIA YAAYYVGTGG GGVNDFLLAD DPPPKKKKSP PPGYYKDLLP PPPPEEEAAA QPPAEEEEFA YLLSSPDFSS SS--DALLAK KPPPGGGGSS SSGHHTTMMP PPPPKKKAAA EPPAEENNFA YLLSSPDFSS SS--DALLAK KPPPGGGGSP PPGHHTTMMP AAAAKKKAAA EPPVEEKKLA FLMSSPDASS SS--DGLLAD DPPPTTTTSE EEGHHQIMMP PPPPRRRAAA KPPPEETTIA YAMDDPERKK KK--DAIIAD DPPPAAAASP PPAGGQAMMP PPPPRRRAAA KPPAEEKKLA YVRNNPMANN NNG-DAMMCD DSSSQQQQSS SSGGGVDMMP PPPPKKKAAA QPPREERRLG YALDDPGREE EE--DALLGD DPPPDDDDSG GGAGGREMMP LLLLEEEMMM -PPREEEEIV YPCYYRNTGG GGTEDYLLAD DPPPKKKKSP PPSHHRPMMP ---------- -PPREEEEIV YPCYYRNTGG GGIEDYLLAD DPPPKKKKSP PPSHHRPMMP LLLLEEEMMM -PPREEEEIV YPCYYGNTGG GGIEDYLLAD DPPPKKKKSP PPCHHRPMMP -------MMM -PPREEEEII YPCYYRNTGG GGIEDYLLAD DPPPKKKKSP PPCHHRPMMP LLLLEEEMMM -PPREEEEIV YPCYYRNTGG GGTEDYLLAD DPPPKKKKSP PPCHHRPMMP LLLLEEEMMM -PPREEEEIV YPCYYRNTGG GGTEDYLLAD DPPPKKKKSP PPCEE----- LLLLEEEMMM ---------- ---------- --TEDYLLAD DPPPKKKKSP PPCHHRPMMP LLLLEEEMMM -PPREEEEIV YPCYYRNTGG GGTEDYLLAD DPPPKKKKSP PPCHHRPMMP QQQQEEEMMM -PPREEEEIV YPCYYRNTGG GGTEDYLLAD DPPPKKKKSP PPSHHRPMMP LLLLEEEMMM -PPREEEEIV YPCYYRNTGG GGTEDYLLAD DPPPKKKKSP PPCHHRPMMP LLLLEEEMMM -PPREEEEIV YPCYYRNTGG GGTEDYLLAD DPPPKKKKSP PPCHHRPMMP LLLLEEEMMM KPPREEKKLV YTCYYNGTGG GGINDYLLAD DPPPSSSSSP PPSHHRPVVI ---------- ---------- ---------- ---------- ---------- -------MMP LLLLDDDMMM -PPREEEEIV YPCYYRSTGG GGINDYLLAD DPPPKKKKSP PPSHHRPMMP IIIIEEEMMM -PPREESSLI YTAYYAGTGG GGIEDYLLAD DPPPSSSSSP PPSHHRPVVP LLLLEEEMMM -PPREETTLI YTAYYAGTGG GGIEDYLLAD DPPPNNNNSP PPSHHRPVVP ---------- ---------- ---------- ---------- ---------- -------MMP LLLLAAAMMM -PPSEEKKLI YTAYYTGTGG GGIDDYLLAD DPPPSSSSSP PPSHHRPMMP LLLLEEEMMM KPPREEKKLL YTCYYNGTGG GGINDYLLGD DPPPNNNNSP PPSHHRPVVT AAAADDDIII -PPREEEEVL FTA----NAA AAADDAIIFN NPPPEEEESD DDCSSRDVVP AAAADDDIII -PPREEEEVL FTA----HAA AARDDAIIFN NPPPEEEESE EECSSRDVVP ---------- ---------- ---------- ---------- ---------- ---------- LLLLDDDVVV NPPVEEKKLL YVCQQPNLDD DDEEDYLLAD DPPPAAAASP PPCHHRYTTN -------MMM SPPREEKKLL YVTQQPNLDD DDEPDYLLSD DPPPEEEESP PPCHHRFTTN ----DDDLLL SDDDRRFFLY FNWHHGDIRR RRQYTDRRKV VGGGQQQQVF FFGKKDPVVK PPPPYYYPPP IGGQEEEEFV YWTGGVEGMM MMGDDKLLVR RPPPGGGGSA AAGNNSSVVG PPPPYYYKKK IGGQEEDDYV YWTGGAEGVV VVGDDKLLVN NPPPKKKKSP PPGNNTSVVG YIIDDEELGG GWNNACSSLL -PNN-KKPPN IEERFIIILR SRRYYYIITT KKPPRRIKEK YIIDDEELGG GWNNACSSYY -PNN-KKPPF LEERYIIILR SRRYYYIVTT KKPKRRVKVV NTTDDEEFGG GWNNACSSLL -PLLGHHAAF LEERFIIILR SRRYYYVITT KKPPTTIKEL NKKDDEEFGG GWNNACSSLL -PLLGHHAAF IEERYIIILR SRRYYYIITT KKPPTTIKEF NKKDDEEFGG GWNNACSSLL -PLLGHHAAF LEERYIIIIR SRRYYYIVVV KK-PLLIKEF HAADDEELGG GWNNACSSLL -PNNPHHPPH MEERYVVVLR SRRYYYILTT KKPPLLLKTA YTTGGEELGG GWNNACSSLL -PNNPHHPPH VEERYVVVIR SHHTTTILTT KKPPTTVKEA NAADDEELGG GWNNACAALL -PYYPHHPPH VEERYIIIIR SRRHHHIVTT KKPPRRIKEH YLLDDEELGG GWNNTCSS-- ----GDDSST KSSNKIIILM SRRYYYVVVV GGSPRRLKEQ HLLDDEELGG GWNNTCSS-- ----GDDSST KSSDKIIIII SRRYYYVVVV GGSPRRLKEH NLLDDEELGG GWNNACSS-- ----GDDSST KSSTKMMMLM SRRYYYVVVV GGSPRRLKDH HLLDDEELGG GWNNTCSS-- ----GDDIIT KAATKVVVLI SRRYYYVVVV GGTPRRLKDH NLLDDEELGG GWNNTCSS-- ----GDDSST KSSTKVVVLI SRRYYYVVVV GGSPRRLKDH ---------- ---------- ---------- ---------- ---------- --------DH NLLDDEELGG GWNNTCSS-- ----GDDSST KSSTKVVVLI SRRYYYVVVV GGSPRRLKDH NLLDDEELGG GWNNTCSS-- ----GDDSST KSSTKVVVLI SRRYYYVVVV GGSPRRLKDH YLLDDEELGG GWNNTCSS-- ----GDDSST KSSNKVVVFI SRRYYYVVVV GGTPRRLKDH NLLDDEELGG GWNNTCSS-- ----GDDSST KSSTKVVVL- ---------- ---------- NLLDDEELGG GWNNTCSS-- ----GDDSST KSSTKVVVLI SRRYYYVVVV GGSPRRLKDH HIIDDKKLGG GWNNSCSS-- ----GDDPPS AKKRFIIILL GRRYYYVVTT AATPRRLKDA NTTDDEELGG GWNNTCSS-- ----GDDAAS KVVNKIIILI SRRYYYVVVV GGTPRRIKEF NVVDDEELGG GWNNTCSS-- ----GDDSSS KVVNKIIILI SRRYYYVVVV GGSPRRIKEF YVVDDEELGG GWNNSCSS-- ----GDDPPS AEERFIIILV GRRYYYVITT KKTPRRLKDI YVVDDEELGG GWNNSCSS-- ----GDDPPS AQQRFIIIIV GRRYYYVITT KKTPRRLKDS FVVDDEELGG GWNNSCSS-- ----GDDAAS ADDRYVVVLI GRRYYYAITT KKEPRRLKEA FVVDDEELGG GWNNSCSS-- ----GDDAAS VDDRYVVVLI GRRYYYAITT KKEPRRLKEA HVVDDEELGG GWNNACSS-- ----GDDPPS ASSRFIIILL GRRYYYVVTT LLKPRRLKDA HIIDDEEVGG GWNNACSS-- ----DKKPPT EKKSHIIILN DRRYYYIIVV EEN-RRLHKH NIIDDEEVGG GWNNACSS-- ----DKKPPT EKKSHIIILN DRRYYYVIVV EEN-RRLHKH ---------- ---------- ---------- -----VVVLS GVVGGGKVVV GGG------- SKKNNEELGG GWNNTCSSHH VP--GKKEEV PTTDRVVVLN DRRFFFVITT GGTPRRLKDL RKKDDEELGG GWNNACSSYY VDEESKKTTV PKKDRVVVLN DFFYYYILVV VVTPRRIKDL VLLDDKKEQQ QPTTPRLL-- ----GKKRRV QGGPQLLLLD KRRYYYVTSS LLYAWWFPDI G--NNEEAGG GFSSA----- ---------- -DDRFWWWLD NRRFFFIFVV HHSPSSLKFK G--NNEEADD DFTTD----- ---------- -DDRYWWWLD SKKFFFVFVV HHSPAALKFE KVVGGYYRHC PAIIYSSNNE ---EGGEEGG IMLDDDYPLG KWEDDDRGGD YYYY------ VRRGGYYKHC PAIIYSSGGP ---DGGEEGG ILLDDDDPIG RWEYYYRGGP YYYY------ LKKGGYYRHC PGIIYSSGGA GKKDGGDDPG IIMDDDEVLG RWEDDDRGGP DDDD------ FKKGGYYRHC PGIIYSSGGG GKKDGGNNPG VIMDDDEVLG RWEDDDRGGP TTTT------ FKKGGYYRHC PGIIYSSGGG GEEDGGDDPG IILDDDEILG RYEDDDRGGE TTTT------ ARRGGYYRHC PGIIYTTNNA ---EGGKKGG IMLDDDQPLG RWEEEERGGP YYYY------ ARRGGYYRHC PGIIYSSSSP ---EGGEEGG IILDDDDVLG RWEDDDRGGD YYYY------ HRRGGYYRHC PGVVYSSSSP ---EGGDDGG VVMDDDEPLG RWEEEERGGP QQQQ------ QKKNNVVNHC AGEEVVVGGD ---LQQNNGS FLLDDDEVKG TWEPPPGGGA PPPP------ HKKNNLLNHC AGEEVIIGGD ---PQQNNGG FLLDDDEVKG TWEPPPGGGE PPPP------ HKKGGLLYHC AGEEVIIGGD ---SKKNNGG FLLDDDEVKG TWEPPPGGGA PPPP------ HKKNNLLFHC PGEEVVVGGD ---PEENNGG FLLDDDKVKG TWEPPPGGGA PPPP------ HKKEELLFHC AGEEVIIGGD ---VKKNNGG FLLDDDEVKG TWEPPPGGGA PPPP------ HKKEELLFHC AGEEVIIGGD ---VKKNNGG FLLDDDEVKG TWEPPPGGGA PPPP------ HKKEELLFHC AGEEVIIGGD ---VKKNNGG FLLDDDEVKG TWEPPPGGGA PPPP------ HKKEELLFHC AGEEVIIGGD ---VKKNNGG FLLDDDEVKG TWEPPPGGGA PPPP------ HKKGGLLTHC PGEEVIIGGD ---PKKNNGG FLLDDDEVKG TWEPPPGGGS PPPP------ ---------- ---------- ---------- ---------- ---------- ---------- HKKEELLFHC AGEEVIIGGD ---VKKNNDG SVLLLL-CSG ---------- ---------- ANNGGLLFHC AGDDIIIGGD ---KEENNGN GLLLLLSVKG RGSRRRLFFP SSSS------ FKKGGLLNHC GGEEIIIGGD ---PYYNNGG FLLDDDEVKG NWEEEEGEEA PPPP------ FKKGGLLNHC GGEEIIIGGD ---PCCNNGG FLLDDDEVKG NWEEEEGEES QQQQ------ IKKGGLLYHC AGEELIIGGD ---KDDNNGN GLLLLLSVKG RWEPPPGHHS LLLL------ SKKGGLLYHC AGEEIIIGGD ---KDDNNGN GLLLLLSVKG RWEPPPGHHS LLLL------ AKKGGLLYHC AGEEIVVGGD ---EEENNGN GLLLLLSIKN RWEPPPGHHS LLLL------ AKKGGLLFHC TGEEIVVGGD ---EEENNGN GLLLLLSIKN RWEPPPDIIS LLLL------ AKKGGLLFHC AGEEIIIGGD ---KEENNGN GLLLLLSVKG RWEPPPGHHS LLLL------ HLL--LLFHC AGNNIIIGGE ---ANNTTGN FLLDDDKPKG TWPDDDEKKT PPPP------ HLL--LLFHC AGNNIIIGGE ---ADDSSGN FLLDDDKPKG TWPDDDGKKV PPPP------ ---------- ---------- ---------- ---------- ---------- ---------- LGGDDCCAHC PGNNIIIGGD ---AEENNG- DVEFFFKLVG TWSGGGDRRK LLLL------ LSSNNVVAHC AGNNIIIGGD ---AEEYYG- DILFFFSCIG TWTGGGDKKK LLLL------ IFFVVLLIDY PTAALQQNNE ---SLLVVLN GQTSSSHLSA KGESSSQFFE IIII------ KSSGGVVGFA PSMMMTTNND ---DDDGGTA LEYNNNDVAT YWMTTTADDD QQQQAAGVDG ESSGGVVGYA PRMMLTTNNN ---KDDGGTA LEYTTTAVAT HWITTTDGGD RRRRAKGYDG LDDFFFWWLL L--NEELLVV SSSSEEWWWV VN--IIEE-- -LLKEEEHHL DDRRFFWDKK FDDFFFWWLL L--SGGMMII TSSSEEWWWV VR--FFEE-- -FFSEEECCL EEAKVVWDRR KDDFFFWWLL L--RDDMMVV SSSSEEWWWL LP--FFEE-- -IIVEEEDDL AAKRFFWDRR LDDFFFWWLL L--RDDMMVV TSSSEEWWWL LP--FFEE-- -IIVEEEDDL SSKRFFWDRR KDDFFFWWLL L--RDDMMVV SSSSEEWWWL LP--FFEE-- -IIVEEEDDL SSKKFFWKKK FDDGGGWWLL L--YDDLLVV TSSSEEWWWT TD--VVEE-- -LLVDDDIIL GGRRFFWDRR LDDFFFWWLL L--YDDLLLL TSSSEEWWWT TR--VVEE-- -VVLDDDEEL AAKRVVWDRR LDDFFFWWLL L--YDDMMVV TSSSEEWWWT TN--IIEE-- -LLDQQQIIL NNGRIIWDRR MDDFFFWYPP P--HNNMMVV STTTEEWWWA AN--FFKKFF FNNPHHHVVE --LRVVWDEE MDDFFFWYPP P--HNNMMVV STTTEEWWWA AN--FFKKFF FNNPHHHVVE --LHVVWDEE MDDFFFWYPP P--HNNMMII STTTEEWWWA AN--FFRRFF FNNPDDDVVE --LHVVWDEE LDDFFFWYPP P--HNNMMII STTTEEWWWA AN--LLRRFF FNNPDDDVVK --LHVVWDEE SDDFFFWYPP P--HNNMMII STTTEEWWWA AN--LLRRFF FNNPDDDVVE --LHVVWDEE LDDFFFWYPP P--HNNMMII STTTEEWWWA AN--LLRRFF FNNPDDDVVE --LHVVWDEE LDDFFFWYPP P--HNNMMII STTTEEWWWA AN--LLRRFF FNNPDDDVVE --LHVVWDEE LDDFFFWYPP P--HNNMMII STTTEEWWWA AN--LLRRFF FNNPDDDVVE --LHVVWDEE MDDFFFWYPP P--HNNMMII STTTEEWWWA AN--VVQQFF FNNPDDDVVE --LHVVWDEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AAAIISSSH HN--RRLLSS SRRDPPPAAS --RI------ KTTHHHLYNN NYYWGGFFWW SWWWIIQQQC CL--YYTTAA AEELCCCLLT --GILLDNVV FDDFFFWYPP P--HNNMMII STTTEEWWWA AK--FFAAFF FKKMEEEVVQ --MSVVWDRR FDDFFFWYPP P--HNNMMII STTTEEWWWA AK--FFAAFF FKKMDDDVVQ --HSVVWDRR FDDFFFWYPP P--HNNMMII STTTSSWWWA AT--FFTTFF FDDLHHHVVA --LHCCIQEE FDDFFFWYPP P--HNNMMII STTTSSWWWA AK--FFLLFF FNNLHHHVVA --LHVVYSEE FDDFFFWYPP P--HKKMMII STTTSSWWWA AK--FFSSFF FDDLHHHVVA --LHVVYSEE YHHFFFWYPP P--HKKMMII STTTSSWWWA AK--FFSSFF FNNLHHHVVA --LHVVYSEE FDDYYYWYPP P--HKKMMII SSSSSSWWWA AA--FFRRFF FDDLHHHVVQ --LHVVYDEE FDDFFFWYPP P--RNNMMII STTTEEWWWS SN--IIKKFF FNNPHHHVVG --LSIIFEKK FDDFFFWYPP P--RNNMMII STTTEEWWWS SN--IIKKFF FNNPHHHVVP --LSIIFEKK ---------- ---------- SIIILLRRRG GV--VVCCEE EEELCCCQQP --LCVVY--- CDDYYYWYPP P--FNNMMVV ASSSEEWWWA AK--FFRRYY YHHPDDDCCD RRQRFFYREE CDDFFFWYPP P--FDDMMVV SSSSEEWWWA AN--WWRRWW WKKNDDDLLE MMQRFFYKTT LSSNNNHNGG G--REESSEE SDDDRRPPPE EI--AAFFSS SEESLLLKKK GGLHEEVL-- YDDIIIRAII I--KNNMMLL TSSSSSFFFG GSNYMMDDQQ QMMLDDDAAE MMRTQQWDQQ YDDVVVRAPP P--KNNLLVV TSSSSSFFFG GNNYMMDDKK KMMLDDDPPE MMHTTTWDQQ RISLTGEEEN NNNMA----- -ELLRLDPMM IVVVKKKDLL SSIWFFY-EE DGKKWNAAEV HLAIDGQQQH HHHMV----- -EVVRLDPMM VVVLKKKDLL SSIWFFY-EE DGKKWQAAEV NVTIDGAAAH HHHMA----- -EVVRADPYY VVVVTTTNLL GSIWWWR-EE GGKKFHVVKT NVTIDGAAAH HHHMA----- -EVVRADPYY VVVVTTTNLL ASIWWWR-EE GGKKFHAAET NVTIDGAAAH HHHMA----- -EIIRADPYY CVVVTTTNLL GAIWWWQKDD DGTTFEAAKT HLEIDGDDDH HHHLV----- -ELLRADPYY VVVIKKKDLL SSIWYYR-DD KDKKWAVVRV HLTLDGAAAY YYYMA----- -ELLRADPYY MVVVKKKDLL ASIWYYR-DD NGSSWHLLKV HLALDGEEEH HHHMV----- -ELLRADPYY VVVVEEEDLL ASVWHHR-QQ NGSSWGIIRV IITLQT---D DDDLI----- -EIIRLDPQQ VAALNNNIQQ FYKEGG---- ---------- IITLQK---D DDDLI----- -EIIRLDPQQ VAALNNNIQQ FYKGGG---- ---------- IITLTQ---D DDDLI----- -EIIRLNPQQ VAALTTTIQQ FYKGGG---- ---------- IVTLPQ---D DDDLI----- -EIIRLNPQQ VAALTTTIQQ FFKDGG---- ---------- IVTLSK---D DDDLI----- -EIIRLNPQQ VAALTTTIQQ FYKGGG---- ---------- IVTLSK---D DDDLI----- -EIIRLNPQQ VAALTTTIQQ FYKGGG---- ---------- IVTLSK---D DDDLI----- -EIIRLNPQQ VAALTTTIQQ FYKGGG---- ---------- IVTLSK---D DDDLI----- -EIIRLNPQQ VAALTTTIQQ FYKGGG---- ---------- IVTLLP---D DDDHI----- -EIIRLDPQQ VAALTTTIQQ FYKGGG---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IDSLPQ---D DDDAGNNNPP ICLLRIWKQQ DEEVSSSGRR GSDAYY---- ---------- RITIDGEEED DDDLI----- -EIIRLDPQQ VAALTTTVFF FYKDGG---- ---------- LVTIDGKKKD DDDLI----- -EIIRLNPQQ VAALSSSIFF FYKDGG---- ---------- LRTLDGNNNT TTTLL----- -EIIRLDPTT VAALNNNMII FFKDGG---- ---------- IKTLDGDDDK KKKLL----- -EIIRLDPTT VAALNNNMII FFKDGG---- ---------- MKLIDGEEET TTTLL----- -EIIRLDPTT VAALNNNMII FFKDDD---- ---------- IKLIDGPPPT TTTLL----- -EIIRLDPTT VAALNNNMII FFKDEE---- ---------- LKTLDGSSST TTTLL----- -EVVRLDPTT VAALNNNMVV FFKDGG---- ---------- YLTIDPQQQL LLLAL----- -EVVRLEPHH VAALGGGIFF IHPENNS--- ---------- HLTIDPMMMR RRRAL----- -EVVRLEPHH VAALAAAIFF IHPKNNP--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LFTIDGDDDD DDDLT----- -EIIRLNPQQ VAAFXXXXXX XX-------- ---------- LYTIDGSSSD DDDIT----- -EIIRLNPEE VAALKKKVFF FKKDSSD--- ---------F ---------- ---------- ---------- ---------- ---------- ---------- PKVFNPGGGP PPP------- -EIIRPGSYY SAALQQQLWW IYEAGG---- ---------- PKVFDPGGGP PPP------- -EIIRAGEYY TAALQQQLWW IYEEGG---- ---------- IEEPEG-LPP PPEKPPPLVI SSSSSDFFYW GIEQYYDISS NFKVTTTKKV KGGIH----- IDDEEG-LPP PPPKPPPLVI SSSSSDFFYW GLEQYYDITT NHQRAAARRV KGGLH----- ATTPTADLPP PPPGPPPLVL SSSSSDFFYW GTEQYYDVSS DHNVAAASSV RGGIH----- ATTPPKELPP PPPGPPPLVL SSSSSDFFYW GTEQYYDVSS DRKKAAASSV HGGIH----- ITTDDADLPP PPDGPPPLVL SSSSSDYYYW GLEQYYDVSS DMNVTTTKKV EGGIH----- IEEPDPDLPP PPPKPPPLVL SSSSSDFFYW GTDQYYDVSS DFEKTTTKKV RGGIHGG--- IDDPSEDLPP PPPKPPPLVL SSSSSDFFYW GTEQYYDVSS DFNRTTTKKV QGGIH----- IEEPEPDLPP PPPGPPPLVL SSSSSDFFYW GTEQYYDVSS DFNRTTTSSV RGGIH----- TWWVQVPKKK KKVPPPGLIL SSSSSDFFYW LHDQYYDISS NQKRTTTQQI FGGSSQQVLL TWWVQVPKKK KKVPPPGLIL SSSSSDFFYW LHDQYYDISS NKKRTTTQQI FGGSSQQVLL TWWVQVPKKK KKVPPPGLIL SSSSSDFFYW LHDQYYDISS DQRRTTTQQL FGGSPQQVLL TWWAQVPKKK KKVPPPGLIL SSSSSDFFYW LHDQYYDVSS DQRRTTTQQL FGGSPQQVLL TWWVQVPKKK KKVPPPGLIL SSSSSDFFYW LHDQYYDISS DQRRTTTQQL FGGSPQQVLL TWWVQVPKKK KKVPPPGLIL SSSSSDFFYW LHDQYYDISS DQRR------ ---------- TWWVQVPKKK KKVPPPGLI- ---------- ---------- ---------- ---------- TWWVQVPKKK KKVPPPGLIL SSSSSDFFYW LHDQYYDISS DQRRTTTQQL FGGSPQQVLL TWWVEVPKKK KKVPPPGLIL SSSSSDFFYW LHDQYYDISS DKRRVVVQQI FGGSPQQVLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AVVLDLYAVV VVVVSSNEFI FFFFFSLLI- ---------- ---------- ---------- KWWAKVPKKK KKVPPPGLII SSSSSDFFYW LHDQYYDITT DRNKVVVQQI FGGSPTTVLL KWWAQVPKKK KKVPPPGLII SSSSSDFFYW LHDQYYDITT DRNKVVVQQI FGGSPTTVLL SWWHPVKLKK KKVPPPGLII SSSSSDFFYW LHDQYYNIEE DKNVTTTQQL WGGLPAAAII SWWHSVELKK KKVPPPGLII SSSSSDFFYW LHDQYYNIEE DKNKTTTQQV WGGLPVVAVV TWWYSVKLKK KKVPPPGLII SSSSSDFFYW LHDQYYNIEE DKNVTTTQQI WGGLPKKAVV TWWHSVKLKK KKVPPPGLII SSSSSDFFYW LHDQYYNIEE DKNVTTTQQI WGGLPKKAVV SWWHSIKLKK KKVPPPGLII SSSSSDYYYW LHDQYYNIEE DAKVAAAQQV WGGLEVVYVV THHAFIPKKK KKVPPPALII SSSSSDFFYW LHDQYYDISS DLKKNNNQQV YGGSNKKVLL VQQATIPKKK KKVPPPALII SSSSSDFFYW LHDQYYDISS DKNKNNNQQV FGGSTKKVLL ---------- ---------- ---------- ---------- ---------- ---------- --------QQ QQGEGGGMMI SSSSSDYYYW RHDQYYDISS DANRTTTQQV FGGAPRRVLL EAAKPGKVDD DDTEGGGMII SSSSSDFFYW RHDQYYDITT DENKTTTQQL FGGAPVVIVV ---------- ---------- ---------- ---------- ---------- ---------- ----EWQKAA AAVPIIPLPI AAAAADTTWF MDKLFFDISS DHKFIIIEEK VRRQ------ ----EWQKAA AAVPVVPLPI SSSSSDRRWF MDKLFFDISS DHHRVVVEEK TAAQ------ ---------- -----GGKKK LGAAAPPQQM MISSRDDGGR RRYVLLWDNN FYYPGKKGWW ---------- -----GGEEE AGAAAPPQQM MVSSRDDGGR RRYILLWNNN FYYPGRRGWW ---------- -----GGTTT FGGGGPPQQM MISSRDDGGR RRYWLLWDDD FYYPGPPAAA ---------- -----GGAAA FAGGGPPQQM MISSRDDGGR RRYWLLWDDD FYYPGPPGVV ---------- -----GGTTT FYGGGPPQQM MISSRDDGGK RRYWLLWDEE FYYPDGGAAA ---------- -----NNAAA LGGGGPPQQM MISSRDDGGR RRYFLLVDPP FYYPGDDGWW ---------- -----SSEEE LGGGGPPQQM MISSRDDGGR RRYFLLWDEE FYYPGKKGWW ---------- -----SSPPP LGGGGPPQQM MVSSRDDGGR RRYFLLWDEE FYYPGRRGWW E-QQEEELTC PPELVGGRRR IGGGGPPQQM MLSSLDDGGK RRYALLWDKK FYY-DIIREE E-QQEEELTC PPELVGGRRR VGGGGPPQQM MLSSLDDGGK RRYVLLWDKK FYY-NIIREE E-QQEEELKS PPELVGGKKK VGGGGPPQQM MLSSLDDGGK RRYVLLWDKK FYY-DIIREE D-QQEEELDS PPELVGGQQQ VGGGGPPQQM MLSSLDDGGK RRYVLLWDKK FYY-DIIREE E-QQEEELKS PPELVGGRRR VGGGGPPQQM MLSSLDDGGK RRYILLWDKK FYY-DIIREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- E-EEEEELKS PPELVGGRRR VGGGGPPQQM MLSSLDDGGK RRYILLWDKK FYY-DIIREE E-QQEEELKS PPELVGGRRR VGGGGPPQQM MLSSLDDGGK RRYVLLWDKK FYY-DIIREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- E-KKDDDLEC PPDVIGGKKK VGGGGPPQQM MLSSLDDGGK RRYVLLWDKK FYY-DIIKEE E-KKEEELEC PPDVTGGIII IGGGGPPQQM MLSSLDDGGK RRYVLLWDKK FYY-DLLKEE G-DDGGGKTW SSDPEGGKKK LGGGGPPQQM MLTTLDDGGK RRYVLLWDKK FYY-GVVEKK K-DDGGGETW SSDPEGGKKK LGGGGPPQQM MLSSLDDGGK RRYVLLWDKK FYY-KVVEQQ G-DDGGGNSF FFDPQGGSSS LGGGGPPQQM MLSSLDDGGK RRYALLWDRR FYY-EMMDKK G-DDGGGNTF FFEPQGGSSS LGGGGPPQQM MLSSLDDGGK RRYALLWVVV FYY-EMMEKK T-DDDDDKEE YYSPQGGRRR LGGGGPPQQM MLSSLDDGGK RRYVLLWDEE FYYGDVVKKK E-EEKKK--- IIELYGGKKK IGGGGPPQQM MLSSLDDGGK RRYVLLWDDD FYY-EVVKSS E-DDHHHD-- IIPLYGGQQQ IGGGGPPQQM MLSSLDDGGK RRYVLLWDDD FYY-EVVRSS ---------- ---------- -GGGGPPAAK KLSSVDDGGK RRYVFFWDKK FYY-NVVKEE N-PPEEELKE PPEVFGGRRR LGGGGPPQQM MLSSLDDGGR RRYVLLWDKK FYY-EVVAAA KEKKEEELKE PPPRYGGRRR LGGGGPPQQM MLSSLDDGGK RRYVLLWDKK FYY-KVVSQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M MQSSWDDGGK RRYFLLWD-- -------KKK ---------- ---------- ---------M MSSSWDDGGQ RRYYLLWD-- -------KKK WMMVNAA--- PPSGGGGLEE EEEIIEEFFF DFG---RRSS SSSQQRSSSS GGGGASDDDS WMMANVV--- PPEGGGGLEE EEELLEEFFF DFG---RRAA AAAQQRWWWW GGGGATDDDS AQQVHAA--- PPDGGGGLTT TTTLLDDYYW EFPG--RRAA AAAQQREEEE GGGGCTDDDS VEEVNVV--- GGNGGGGLEE EEELLDDYYF SFPG--RRAA AAAQQREEEE GGGGCTDDDS AMMVNVV--- EENGGGGLTT TTTLLDDFFW DFPG--RRSS SSSQQREEEE GGGGCTDDDS WMMVDAA--- PPNGGGGIEE EEEFFKKFFF EWPG--RRPP PPPQQRQQQQ GGGGCSDDDS WMMVDVV--- PPDGGGGMQQ QQQFFNNFFF DFG---RRVV VVVQQRQQQQ GGGGASDDDS WIIAEAA--- PPGGGGGLSS SSSLLGGFFF EVGG--RRPP PPPQQREEEE GGGGSSDDDS EGGSLQQVVD VVNGGGGLKK KKKLLNNFFL DFGEPGLLAA AAAEERPPPP GGGGCSDDDI EGGSLQQVVD AANGGGGLKK KKKLLNNFFL DFGEPGLLAA AAAEERPPPP GGGGCSDDDI EGGSLQQVVD VVKGGGGLKK KKKLLNNFFL DFGEPGLLAA AAAEERPPPP GGGGCSDDDI EGGSLQQVVD VVKGGGGLTT TTTLLNNFFL DFGEPGLLAA AAAEERPPPP GGGGCSDDDI EGGSLQQVVD VVKGGGGLKK KKKLLNNFFL DFGEPGLLAA AAAEERPPPP GGGGCSDDDI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EGGSLQQVVD VVKGGGGLKK KKKLLNNFFL DFGEPGLLAA AAAEERPPPP GGGGCSDDDI EGGSLQQVVD VVKGGGGLKK KKKLLNNFFL DFGEPGLLAA AAAEERPPPP GGGGCSDDDI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EGGSLQQVVD EEKGGGGLKK KKKLLNNFFL DFGEPGLLAA AAAEERPPPP GGGGCSDDDI EGGALQQVVD KKKGGGGLKK KKKLLNNFFL DFGEPGLLAA AAAEERPPPP GGGGCSDDDI KGGSLQQVVD EEKGGGGLKK KKKIINNFFF DFGEPGLLAA AAAEERPPPP GGGGCSDDDI QGGSLQQVVD EENGGGGLKK KKKIINNFFF DFGEPGLLAA AAAEERPPPP GGGGCSDDDI KGGSIQQVVD EEKGGGGLSS SSSIINNFFF DFGEPGLLAA AAAEERPPPP GGGGCSDDDI KGGSIQQGGD EEKGGGGLTT TTTIIDDFFF DFGEPGLLAA AAAEERPPPP GGGGCSDDDI KGGSLQQVVD EEKGGGGLSS SSSIINNFFF DFGEPGLLAA AAAEERPPPP GGGGCSDDDI SGGAVQQIID EESGGKKMEE EEEIIDDFFL DFGIEGLLAA AAAEERPPPP GGGGCSDDDI SGGALQQVVD IITGGHHMVV VVVIINNFFL DFGVPGLLAA AAAEERPPPP GGGGCSDDDI EGGSLQQVVD EEKGGGGLTT TTTVVNNFFL DFGEPGLLAA AAADDRPPPP CCGGSSDDDI AGGGVQQIID EENGGGGMKK KKKLLNNFFL DFGEPGLLPP PPPEER---- ---------- QGGGVLLVVD VVNGGGGISS SSSLLDDFFL DFAEPGLLPP PPPEERPPPP GGGGCSDDDI ---------- ---------- ---------- ---------- ---------- ---------- KGGKAQQKKA NNWDDGGKEE EEELLDDFFA DFYLGGRRAA AAAIIRGGGG SSSSLSSSS- KGGKEQQKKL YYWDDGGKEE EEELLQQFFA DFYEKGRRPP PPPQQRGGGG AARRLAGGGP YC----- FC----- FCR---- FC----- FC----- YC----- YC----- YC----- WI----- WI----- WL----- WL----- WI----- ------- ------- WI----- WL----- ------- ------- ------- WV----- WI----- WI----- WI----- WI----- WI----- WI----- WI----- WI----- LA----- ------- WL----- ------- ------- AGVARVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NKKKKKSEEA ATTTTCCRAV VTTGTARDGM MMMQQLPTTT QLLSSLTPPG SIKKYQEEAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ----MAGGRS gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ATTTFSSSSS IIQQQVAASS SSPRSSSKGT RRRVVPLLLV VEEEIIISSA AAAKQQPVWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------LL ---------- ---------- ---------- ---------- ---------- ---------- SPPPTLPPPP LLNNNNTTPP TTPHPPPLAS PPPHHPVVVP PLLLTTTLLV PPPYRRNLCC ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMI IIVFFFKPFF YPMMMAMAYY VAALLTGGGT ---------- ---------- ---------M MMALLLKPFF YPDDDAMAYY VAALLVGGGT ---------- ---------- ---------- --MMMMRPFF HALLLAMAYY TLLLLPDDDF ---------- ---------- ---------- --MMMMRPFF HALLLAMAYY TLLLLPDDDF ---------- ---------- ---------- --MLLLRPFF YPLLLAMGFF TLLLLPDDDA ---------- ---------- ---------M MMAWWWKPFF YPLLLAAAYY VAAFFPEEER ---------- ---------- ---------M MMVWWWRPFF YPMMMAVAYY VVVLLPMMMA ---------- ---------- ---------M MMAWWWRPFF YPMMMAMAYY VAALLPGGGR ---------- ---------- -----MATTC CCT----PYY PTAAAMKGYY LPPIIRNNNT ---------- ---------- ---------- ---------- ------MGYY LPPIIRNNNT WWWLPPPKKH HGLIIAPARL LLPGAHSTTC CCG----PYY PSAAAMKGYY LPPIIGNNNT ---------- ---------- ---------- ---------- -----MKGYY LPPIIRNNNT ---------- ---------- -----MATTC CCG----PYY STAAAMKGYY LPPIIRNNNT ----AEEAAE EGLQQSVAQM RRPISTATTC CCG----PYY STAAAMKGYY LPPIIRNNNT ---------- ---------- -----MATTC CCG----PYY STAAAMKG-- ---------- ---------- ---------- -----MATTC CCG----PYY STAAAMKGYY LPPIIRNNNT GGGLGKKEEP PGQPPWFLSQ LLWQDTATTC CCG----PYY PTAAAMKGYY LPPIIRNNNT NNNSQGGLLG GFNTTELHTC TTLVTSPTTC CCG----PYY STAAAMKGYY LPPIIRNNNT ---------- ---------- -----MATTC CCG----PYY STAAAMKGYY LPPIIRNNNT HHHARHHLLV VLMEEGAAAE TTAAANGKKC CCCTTTAPYY ATAAAMEGYY VTTVVNGGGT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MAAC CCG----PYY KSAAAMKGYY LPPIIRSSST ---------- --MAATVLDG VVVNKKS--N NNGCCCKPYY ASSSSMSGYY VTTVVAGGGT ---------- --MGGTVLQA VVVSKVNNNQ QQGCCCKPYY ASAAAMSGYY VTTVVAGGGT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R RRMQQQVPYY ATAAAMSGYY VTTVVTGGGT ---------- ---------- MMAAANGAAC CCCGGGAPYY ATAAAMEGYY VTTVVNGGGT ---------- ---------- --MSNCGLLC CCH----PYY ASAAAIKGFF VTTPP----N ---------- ---------- --MP-CPLLC CCH----PYY ASAAAIKGFF VTTPP----H ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MME EESCCCKPYY ATAAAVRGYY VVVVVPNNNL ---------- ---------- ---------- ---------- -----MRGYY TVVVVPNNNL ---------- ---------- ---------- -------PLL ITIIILILFF SNNLLGDDDI ---MKRREEF FG-------L AAAGALAMML LLPRRRADTT CQMMMPKTYY VWWLLVEEEG ---MKRRIIV VSMHHFALRL VVSGALALLA AAPGGGVDTT CAMMMKKTYY VWWLLAEEEG TTTGIINRDD DFFFVVVNPP KSSETTTTKI VHELINLHHF FWWCSSSSLC CC-PNGKKPN TTTGVVNADD DFFFVVVDPP KSSPTTTTKV IYDLIGLHHF FWWCSSSSYC CC-PNAKKPF FFFS---RDD DAAAIIIKPP GSSSTTTTKI VHTMTGFHHF FWWCSSSSLS SS-PLTHHAF FFFS---KDD DAAAIIIKPP GSSPTTTTQI VHTMKGFHHF FWWCSSSSLS SS-PLAHHAF AAAS---KDD DGGGVVVDPP TSSEKKKKQI VHIMKGFHHF FWWCSSSSLS SS-PLTHHAF RRRK---QDD DAAAVVVDPP ASSPRRRRSI VGAMAGLHHF FWWCSSSSLC CC-PNAHHPH AAANGG-KDD DAAAVVVDSS QSSSTTTTQV VGDMTGLHHF FWWCSSSSLC CC-PNAHHPH RRRE---RDD DAAALLLDPP DSSGTTTTQI VGEMAALHHF FWWCSSAALC CC-PYAHHPH TTTGTTEADD DYYYVVVDPP KSSPQQQQQV IHPMLKLHHS SWWCSSSS-- -----FDDST TTTGIIEADD DYYYVVVDPP KSSPHHHHQV IHPMLKLHHS SWWCSSSS-- -----FDDST TTTGIIEADD DYYYVVVDPP KSSPQQQQQV IHPMLRLHHS SWWCSSSS-- -----FDDST TTTGIIEADD DYYYVVVDPP KSSPQQQQQV IHPMLKLHHS SWWCSSSS-- -----YDDIT TTTGTTEADD DYYYVVVDPP KSSPQQQQQV IHPMLKLHHS SWWCSSSS-- -----FDDST TTTGTTEADD DYYYVVVDPP KSSPQQQQQV IE-------- ---------- ---------- ----TTEADD DYYYVVVDPP KSSPQQQQQV IHPMLKLHHS SWWCSSSS-- -----FDDST TTTGTTEADD DYYYVVVDPP KSSPQQQQQV IHPMLKLHHS SWWCSSSS-- -----FDDST TTTGTTEADD DYYYVVVDPP KSSPQQQQQV IHPMLKLHHS SWWCSSSS-- -----FDDST TTTGTTEADD DYYYVVVDPP KSSPQQQQQV IHPMLKLHHS SWWCSSSS-- -----FDDST TTTGTTEADD DYYYVVVDPP KSSPQQQQQV IHPMLKLHHS SWWCSSSS-- -----FDDST TTTGIINKDD DYYYVVVDPP SSSPTTTTQV IHPVIGLHHS SWWCSSSS-- -----HDDPS ---------- ---------- ---------- ---MTNLHHS SWWCSSSS-- -----YDDAS TTTGIINKDD DYYYVVVDPP KSSPSSSSQV IHPMVNLHHS SWWCSSSS-- -----YDDSS TTTGIIEKDD DYYYVVVDPP SSSPTTTTKV IHPVVGLHHT TWWCSSSS-- -----HDDPS TTTGIIEKDD DYYYVVVDPP NSSPTTTTKV IHPVVGLHHT TWWCSSSS-- -----HDDPS ---------- ---------- ---------- ---MVGLHHS SWWCSSSS-- -----HDDAS TTTGIIDKDD DYYYVVVDPP SSSPSSSSSV IHPMVGLHHS SWWCSSSS-- -----HDDAS TTTGIINKDD DYYYVVVDPP NSSPTTTTQV IHPVVGLHHS SWWCSSSS-- -----HDDPS NNNAAADGDD DAAAVVVNPP ESSDTTTTQV ISDVIGVHHT TWWCSSSS-- -----HKKPT HHHARRDGDD DAAAVVVNPP ESSETTTTQI ISDVIGVHHT TWWCSSSS-- -----HKKPT ---------- ---------- ---------- ---------- ---------- ---------- LLLDEEEHDD DYYYVVVDPP ASSPTTTTQV IHYTKHLHHS SWWCSSSSHF FFVP-GKKEV LLLDEEPHDD DYYYVVVDPP ESSPTTTTQI VHFTKGLHHS SWWCSSSSYY YYVDESKKTV IIIRQQYDTT TDDDPPPVGG QVVFLLLLSV LKPVLEEDDS SPPRIILL-- ------KKRV GGGMGGDEDD DKKKIIIRPP GSSATTTTQV INSV-RAHHG GFF------- ---------- GGGVGGDEDD DKKKVVVNPP KSSPQQQQKV VNSV-RAHHS SFF------- ---------- NIIIERFLII VVPGLLRSSS SDDKKNNPRP PPPKIIKVEE PPEEEVKKKV GGSSSLLHHT FLLLERYLII VVPALLRSSS SDDKKDDKRP PPPAAAKIEE PPEVVAVVGR GGTTTYYHHT FLLLERFLII IIPGLLRSSS SDDKKHHPTA AAARHHKIEE PPDEEILLAK GGSSSPPHHT FIIIERYLII IIPGLLRSSS SDDKKDDPTA AAAKHHKIEE PPEEEVFFKK GGSSSPPHHT FLLLERYLII IIPGIIRSSS SDDKKEEPLA AAAKHHKIEE PPEEEVFFAK GGSSSPPHHT HMMMERYLVV VVPGLLRSSS SDDKKDDPLP PPPFAAKVEE PPETTLAAER GGSSSPPHHT HVVVERYLVV VVPDIIRSSS SDDKKDDPTP PPPKVVKVDD PPNEELAAER GGAAAPPHHT HVVVERYLII VVPGIIRSSS SDDKKDDPRP PPPRVVKVEE PPEEELHHRR GGSSSPPHHT TKKKSNKLII LLPGLLMSSS SDDGGEEPRP PPPKHHKVEE AASEEIQQAK NNSSSTTHHT TKKKSDKLII LLPSIIISSS SDDGGEEPRP PPPKHHKVEE PPNEEIHHAK NNGGGLLHHT TKKKSTKLMM LLPCLLMSSS SDDGGDDPRP PPPKHHKVEE AAEDDIHHAK GGGGGVVHHT TKKKATKLVV LLPALLISSS SDDGGEEPRP PPPKHHKVEE PPKDDIHHTK NNGGGFFHHT TKKKSTKLVV LLPSLLISSS SDDGGEEPRP PPPKHHKVEE PPEDDIHHAK EEAAALLHHT ---------- ---------- ---------- ---------- PPKDDIHHAK EEAAALLHHT TKKKSTKLVV LLPSLLISSS SDDGGEEPRP PPPKHHKVEE PPKDDIHHAK EEAAALLHHT TKKKSTKLVV LLPSLLISSS SDDGGEEPRP PPPKHHKVEE PPKDDIHHAK EEAAALLHHT TKKKSNKLVV LLPSFFISSS SDDGGEEPRP PPPKHHKVEE AAKDDIHHEK GGGGGPPHHT TKKKSTKLVV LLPSLL---- ---------- ---------- ---------- ---------- TKKKSTKLVV LLPSLLISSS SDDGGEEPRP PPPKHHKVEE PPKDDIHHAK EEAAALLHHT SAAAKRFLII LLPSLLLSSS GDDAADDPRP PPPSHHKVEE SSEDDIAAEN GGGGGPPHHT SKKKVNKLII LLPCLLISSS SDDGGDDPRP PPPRHHKTEE PPYEEVFFWK GGAAALLHHT SKKKVNKLII LLPCLLISSS SDDGGDDPRP PPPRHHKTEE PPYEEVFFWK GGAAAPPHHT SAAAERFLII AAPSLLVSSS GDDKKNNPRP PPPSHHKVDD PPADDIIIQK GGAAAPPHHT SAAAQRFLII VVPGIIVSSS GDDKKNNPRP PPPSHHKVEE PPEDDISSTK GGAAAPPHHT SAAADRYLVV LLPSLLISSS GDDKKNNPRP PPPSYYKYDD PPKEEIAAEK GGAAAPPHHT SVVVDRYLVV LLPSLLISSS GDDKKNNPRP PPPSYYKYDD PPKEEIAADK GGAAAPPHHT SAAASRFLII LLPSLLLSSS GDDLLDDPRP PPPAHHKVEE AAEDDIAAEK GGGGGPPHHT TEEEKSHLII VVPCLLNSSS DNNEEEE-RI IIIYEEHTEE PPSKKLHHSL --SSSPPHHT TEEEKSHLII VVPCLLNSSS DNNEEEE-RI IIIYQQHTEE PPSKKLHHAL --SSSPPHHT -------MVV PPRKLLSSSS GFFGG----- ---------- ---------- ---------- VPPPTDRLVV LLPCLLNSSS DDDGGDDPRP PPPKAAKVEE GG-DDVLLKG DDTTTPPHHT VPPPKDRLVV LLPSLLNSSS DDDVVDDPRP PPPEVVKTDD GG-DDVLLKS NNTTTPPHHT VQQQGPQMLL QQLSLLDGGG KTTLLSSAWK KKKQYYP--- ---DDLIIKF VVAAASSHHT ----DRFFWW TTGGLLDTTT NDDHHDDPSP PPPKHHKTDD TT-FFVKKDS GGVVVPPHHT ----DRYLWW AAGGLLDTTT SDDHHDDPAP PPPVSSKTTT DD-FFVEEKS GGVVVPPHHT CGPDDAIIIS ALE-E--EGG GGGIILMMML DHFEPLGWED DQQ------- ---AADFNL- CGPDDAIIIS ALP-DRREGG GGGIIFLLLL DHFEPIGWEP PQQ------- ---AADFNL- CGPEEGIVVS TLAKDTTDPP GGGIIFIIIM DCFDVLGWEP PQQ------- ---HHDFNL- CGPDDGIVVS TLGKDTTNPP GGGVVFIIIM DCFEVLGWEP PQQ------- ---HHDFNL- CGPEEGIVVS TLGEDTTDPP GGGIIFIIIL DCFEILGYEE EQQ------- ---HHDFNL- CGPGGGIVVT ALA-E--KGG GGGIIAMMML DAFEPLGWEP PQQ------- ---AADGHL- CGPDDGIIIS ALP-E--EGG GGGIIFIIIL DHLEVLGWED DQQ------- ---HHDFHL- CGPDDGVVVS ALP-E--DGG GGGVVFVVVM DHFDPLGWEP PQQ------- ---AADFHL- CLASSGEMMV NTD-LGGNGG SSSFFVLLLL DGFEVKGWEA ASS------- ---GGDFQP- CLASSGEMMI SSD-PGGNGG GGGFFVLLLL DGFEVKGWEE EAA------- ---GGDFQP- CLASSGEMMI STD-SGGNGG GGGFFVLLLL DGFEVKGWEA AAA------- ---GGDFQP- CLPSSGEMMV STD-PGGNGG GGGFFVLLLL DGFEVKGWEA AAA------- ---GGDFQP- CLASSGEMMI SSD-VGGNGG GGGFFVLLLL DGFEVKGWEA AAA------- ---GGDFQP- CLASSGEMMI SSD-VGGNGG GGGFFVLLLL DGFEVKGWEA AAA------- ---GGDFQP- CLASSGEMMI SSD-VGGNGG GGGFFVLLLL DGFEVKGWEA AAA------- ---GGDFQP- CLASSGEMMI SSD-VGGNGG GGGFFVLLLL DGFEVKGWEA AAA------- ---GGDFQP- CLPTTGEMMI STD-PGGNGG GGGFFVLLLL DGFEVKGWES SAA------- ---GGDFQP- ---------- ---------- ---------- ---------- ---------- ---------- CLASSGEMMI SSD-VGGNDD GGGSSLVVVL LPLECSG--- ---------- ---------- CLASSGDMMI SCD-KGGNGG NNNGGFLLLL LDFNVKGGSP PII------- ---EETHENY CLGCCGEMMI SSD-PGGNGG GGGFFVLLLL DGFEVKGWEA AAA------- ---GGDFQP- CLGCCGEMMI SSD-PGGNGG GGGFFVLLLL DGFEVKGWES SAA------- ---GGDFQP- CLASSGEMMI SCD-KGGNGG NNNGGFLLLL LDFNVKGWES SPP------- ---GGDFQP- CLASSGEMMI SCD-KGGNGG NNNGGFLLLL LDFNVKGWES SPP------- ---GGDFQP- CLASSGELLV SCD-EGGNGG NNNGGFLLLL LDFNIKNWES SPP------- ---GGDFQP- CRT--GELLV SCD-EGGNGG NNNGGLLLLL LDFNIKNWES SPP------- ---GGHFQP- CLASSGEMMI SCD-KGGNGG NNNGGFLLLL LDFNVKGWES SPP------- ---GGDYQP- CLADDGNMMI STE-AGGTGG NNNFFLLLLL DGFEPKGWPT TVV------- ---NNDFQP- CLADDGNMMI STE-AGGSGG NNNFFLLLLL DGFEPKGWPV VVV------- ---NNDFQP- ---------- ---------- ---------- ---------- ---------- ---------- CLPNNGNMMI SID-AGGNGG ---DDFVVVE FDFELVGWSK KAA------- ---GGDYQP- CLANNGNMMI SVD-AGGYGG ---DDFIIIL FDFNCIGWTK KAA------- ---GGDFQP- YQPNNTAKKQ DGE-SSSVLL NNNGGIQQQT SKNGLSAGEE EEE------- ---QQSNNG- ALPGGSMIIT GLD-DHHGTT AAALLVEEEY NDEYVATWMD DMMGGVGGAA VVDGGDILI- ALPGGRMIIT GLN-KHHGTT AAALLVEEEY TNEYVATWID DLLGGIGGKK YYDDDDVLP- -PNNEEVLLL VAP--EDGLL KKKKEEELLD D-YYGNNIIH FRKKKRIHHS LLLGGGEERA -PSSGGVMMM ITP--EEGFF SSSSEEELLE EGYYGNNLLH VAKKKHLYYA ILLGGGQERV -PRRDDYMMM VAP--ENGII VVVVEEELLA ANYYGHHLLH FRAAANVQQT ILLGGGAQQA -PRRDDYMMM VAP--ENGII VVVVEEELLS SNYYGHHLLH FRAAANVQQT ILLGGGANQA -PRRDDYMMM VGP--ENGII VVVVEEELLS SNYYGHHIIH FRDDDNVQQT ILLGGGANQA -GYYDDTLLL VGP--EDGLL VVVVDDDLLG GAYYGRRLLH FTRRRHLQQE IFFGGGDEQV -GYYDDTLLL LGP--ESGVV LLLLDDDLLA AGYYGHHLLH VYRRRHLQQT LLLGGGAEQA -GYYDDTMMM VGP--EGGLL DDDDQQQLLN NKYYGRRLLH IRRRRHLQQA LVVGGGEEQV -RHHNNVMMM VAP--KDGNN PPPPHHHEE- -GYYGSSIIF VQRRRIIQQT LMMTTT--GI -RHHNNIMMM VAP--KDGNN PPPPHHHEE- -GYYGSSIIH VQRRRIIQQT LMMKKK--GI -RHHNNVMMM IAP--RDGNN PPPPDDDEE- -GYYGSSLLH VQRRRIIQQT LLLQQQ--GI -RHHNNVMMM IAP--RDGNN PPPPDDDKK- -GYYGSSLLY VQRRRIVQQT LLLQQQ--GI -RHHNNVMMM IAP--RDGNN PPPPDDDEE- -GYYGSSLLY VQHHHIVQQT LLLKKK--GI -RHHNNVMMM IAP--RDGNN PPPPDDDEE- -GYYGSSLLY VQRRRIVQQT LLLKKK--GI -RHHNNVMMM IAP--RDGNN PPPPDDDEE- -GYYGSSLLY VQRRRIVQQT LLLKKK--GI -RHHNNVMMM IAP--RDGNN PPPPDDDEE- -GYYGSSLLY VQRRRIVQQT LLLKKK--GI -RHHNNVMMM IAP--QNGNN PPPPDDDEE- -GYYGKKLLH VQRRRIVQQT LMMPPP--GI ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AS--LTGRR DDDDPPPSS- -SVVAGGTT- ---------- ---------- YAWWGGLFFF WCS--TTGEE LLLLCCCTT- -SVVHVVSSC LIMMMIDEES LLLQQQ--QG -RHHNNVMMM IGP--ALGKK MMMMEEEQQ- -GYYGHHLLN VTEEERIQQT ILLGGGE-GI -RHHNNVMMM IGP--ALGKK MMMMDDDQQ- -GYYGHHLLN VTEEELVQQT ILLGGGK-GI -RHHNNTMMM IGP--TKGDD LLLLHHHAA- -GYYGRRLLT CARRRLRQQT LLLGGGN-GL -RHHNNTMMM IGP--LQGNN LLLLHHHAA- -GYYGRRLLH VPGGGIKQQT LLLGGGD-GL -RHHKKTMMM IGP--SKGDD LLLLHHHAA- -GYYGSSLLH VPGGGMKQQL ILLGGGE-GL -RHHKKTMMM IGP--SKGNN LLLLHHHAA- -GYYGSSLLH VPGGGIKQQL ILLGGGP-GL -RHHKKTMMM IGP--RTGDD LLLLHHHQQ- -GYYGRRLLH VPGGGLKQQT LLLGGGS-GL -RRRNNVMMM IGP--KKGNN PPPPHHHGG- -GYYGNNVVH IDSSSYLQQT ILLPPPQPGL -RRRNNIMMM IGP--KKGNN PPPPHHHPP- -GYYGNNVVH IDTTTHLQQT ILLPPPMPGL ---------- -GP--CRDEE LLLLCCCPP- -PVVIKKKKR V--------- ---------- -HFFNNVMMM VGP--RRGHH PPPPDDDDDR RTYYGCCLLN FQEEELFQQT ILLGGGD-GT -YFFDDVMMM VGP--RRGKK NNNNDDDEEM MSYYGCCLLN FSTTTLYQQT ILLGGGS-GT --RREEKSSS EDP--FESEE SSSSLLLKKG GPKKPQQVVA E--------- ---------- -RKKNNVMMM LTWNNDFGMM LLLLDDDEEM MKFFGNNIIV QHTTTPKKKV FVVPPPGA-- -RKKNNLLLL VTWNNDFGMM LLLLDDDEEM MKFFGNNVVV THTTTPKKKV FVVPPPGA-- AL-ERPHDPM FIIMMMVVLK SSIWLWW--D KKKKEKVVVI EEIPPEEEEE EPEGGNNLLP VL-ERPHDPM FVVVVVVLTK SSIWLWW--D KKKKERVVVI DDIEEQQQQQ QPEGGPPLLP AL-ERPHDPY FVVVVVVVTT GGIWTWW--G KKKKKKTTTA TTIPPEEEEE EPTAAEELLP AL-ERPHDPY FVVVVVVVTT AAIWTWW--G KKKKEKTTTA TTIPPEEEEE EPPKKKKLLP AL-ERPHDPY FCCVVVVVTT GGIFTWWKKD TTTTKKTTTI TTIDDVVVVV VPDAADDLLP VF-ERPHDPY FVVCCCVILK SSIWTWW--K KKKKRKVVVI EEIPPEEEEE EADPPQQLLP AL-ERPHDPY FMMCCCVVLK AAIWLWW--N SSSSKKVVVI DDIPPEEEEE EPSEEQQLLP VL-ERPHDPY FVVVVVVVLE AAVWLWW--N SSSSRKVVVI EEIPPEEEEE EPEPPQQLLP IP-ERFHDPQ FVVCCCALSN FFKNEEE--- ---------T WWSVVKKKKK KVQVVSSKKK IP-ERFHDPQ FVVCCCALSN FFKNEGG--- ---------T WWSVVKKKKK KVQVVSSKKK IP-ERFHNPQ FVVCCCALST FFKNQGG--- ---------T WWSVVKKKKK KVQVVPPKKK IP-ERFHNPQ FVVCCCALST FFKNEDD--- ---------T WWSAAKKKKK KVQVVPPKKK IP-ERFHNPQ FVVCCCALST FFKNEGG--- ---------T WWSVVKKKKK KVQVVPPKKK IP-ERFHNPQ FVVCCCALST FFKNEGG--- ---------T WWSVVKKKKK KVQVVPPKKK IP-ERFHNPQ FVVCCCALST FFKNEGG--- ---------T WWSVVKKKKK KVQVVPPKKK IP-ERFHNPQ FVVCCCALST FFKNEGG--- ---------T WWSVVKKKKK KVQVVPPKKK IP-ERFHDPQ FVVCCCALST FFKNEGG--- ---------T WWSVVKKKKK KVEVVPPKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GAPCRSHWKQ YDDVVVEVFS GGDPDAA--- ---------A VVVLLRRRRR RKDLLYYAAV IP-ERFHDPQ LVVCCCALST FFKEKDD--- ---------K WWAAAKKKKK KVKVVSSKKK IP-ERFHNPQ LVVCCCALSS FFKEKDD--- ---------K WWAAAKKKKK KVQVVSSKKK LP-ERFHDPT FVVSSSALSN FFKTQDD--- ---------S WWSHHLLLLL LAPVVPPLLK LP-ERFHDPT FVVSSSALSN FFKTQDD--- ---------S WWNHHIIIII IVSVVPPLLK LP-ERFHDPT YVVSSSALSN FFKNSDD--- ---------T WWSYYIIIII IVSVVPPLLK LP-ERFHDPT FVVSSSALSN FFKNSDD--- ---------T WWSHHVVVVV VVSVVPPLLK LP-ERFHDPT YVVCCCALSN FFKTADD--- ---------S WWSHHVVVVV VASIIPPLLK LP-ERFHEPH FVVCCCALSG IIPVEEE--- -----T---T HHAAALLLLL LVFIISSKKK LP-ERFHEPH FVVCCCALSA IIPDEKK--- -----K---V QQTAALLLLL LVTIISSKKK ---------- ---------- ---------- ---------- ---------- ---------- TP-ERFHNPQ YVVCCCAFXX XX-------- ---------- ---------- ---------Q TP-ERFHNPE FVVCCCALAK FFKKSDD--- -----EFFFE AAKKKIIIII IDPGGLLVVD ---------- ---------- ---------- ---------- ---------- ---------- ---ERFWGSY FSSTTTALSQ IIEDDAA--- ---------- ---------- --EWWAAKKA ---ERCWGEY FTTTTTALSQ IIEDGEE--- ---------- ---------- --EWWAAKKA IILPFVVPPP VTIIILLDDD KFFLLWIIGR DSSNNNPFPL LTTTGVVKKG GIFFFFHHHH VVLDFVVPPP VTIIILLDDD RFFLLWLLGR DTTNNNPHPL LAAAGVVKKG GLYYYYHHHH LLLGFVVPPP VTILLLLDDD RFFLCWTTGR DSSDDDPHPL LAAAGVVRRG GIAAAARRRH LLLGFVVPPP VTILLMMDDD RFFLCWTTGR DSSDDDPRPL LAAAGVVHHG GIAAAARRRH LLLGFCCPPP VTILLLLDDD KYYLCWLLGH DSSDDDPMPL LTTTGVVEEG GIVVVVKKKH VVLGFVVPPP VTILLMMDDD RFFLCWTTGL DSSDDDPFPL LTTTGVVRRG GIVVVVSSSH IILPFVVPPP VTILLVVDDD RFFLCWTTGH DSSDDDPFPL LTTTGVVQQG GIVVVVRRRH LLLDFVVPPP VTILLLLDDD RFFLCWTTGR DSSDDDPFPH HTTTGVVRRG GIVVVVRRRH KKGMLMMPGG ITILLLLDDD RFFLNWHHGR DSSNNNPQPL LTTTGIIFFG GSIIIIVVVS KKGMLMMPGG ITILLLLDDD RFFLNWHHGR DSSNNNPKPL LTTTGIIFFG GSIIIIVVVS KKGMLMMPGG ITILLLLDDD RFFLNWHHGR DSSDDDPQPL LTTTGLLFFG GSIIIIVVVP KKGMLMMPGG ITILLLLDDD HFFLNWHHGR DSSDDDPQPL LTTTGLLFFG GSIIIIVVVP KKGLLMMPGG ITILLLLDDD RFFLNWHHGR DSSDDDPQPL LTTTGLLFFG GSIIIIVVVP KKGLLMMPGG ITILLLLDDD RFFLNWHHGR DSSDDDPQPL L--------- ---------- KKGLLMMPGG IT-------- ---------- ---------- ---------- ---------- KKGLLMMPGG ITILLLLDDD RFFLNWHHGR DSSDDDPQPL LTTTGLLFFG GSIIIIVVVP KKGMLMMPGG ITILLLLDDD RFFLNWHHGR DSSDDDPKPL LVVVGIIFFG GSIIIIVVVP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAKGVLLSNN FPAIIFFSDD LLLIS----- ---------- ---------- ---------- EEGALMMPGG ITIIILLDDD RFFLNWHHGR DTTDDDPRPL LVVVGIIFFG GSIIIILLLP EEGPMMMPGG ITIIILLDDD RFFLNWHHGR DTTDDDTRPL LVVVGIIFFG GSIIIIQQQP QQNILMMPGG ITFIILLDDD RFFLNWHHGR NEEDDDLKPL LTTTGLLWWG GLIIIIQQQP QQNFLMMPGG ITFIILLDDD RFFLNWHHGR NEEDDDVKPL LTTTGVVWWG GLIIIIQQQP EENILMMPGG ITFIILLDDD RFFLNWHHGR NEEDDDPKPL LTTTGIIWWG GLLLLLQQQP EENILMMPGG ITFIILLDDD RFFINWHHGR NEEDDDPKPL LTTTGIIWWG GLLLLLQQQP RRNILMMPGG ITFIILLDDD RYYLNWHHGR NEEDDDPAPL LAAAGVVWWG GLLLLLQQQE SSGALMMPAA ITIIIMMDDD RFFLCWHHGR DSSDDDPLVL LNNNSVVYYG GSVVVVHHHN EENALMMPAA ITIIIMMDDD RFFLCWHHGR DSSDDDPKPL LNNNSVVFFG GSIIIIHHHT ---------- ---------- ---------- ---------- ---------- ---------- EENEIMMGGG MTIIILLDDD RYYLNWHHGR DSSDDDRAPL LTTTGVVFFG GAIIIIQQQP GGSVAMMGGG ISIIILLDDD RFFLCWHHGR DTTDDDPEPL LTTTGLLFFG GAIIIICCCP ---------- ---------- ---------- ---------- ---------- ---------- AADGNDDIPP PVIIIAADDD QTTLSFDDGR DSSDDDPHPQ QIIIYKKVVR RQVVVVNNN- AADGEKKVPP PVIIINNDDD SRRLTFDDGR DSSDDDPHPQ QVVVYKKTTA AQVVVVNNN- PP-------- --AAGHKLLT TGAAPPMMMM LLIIGRRVYY VTTTTNSLLY SSDNFFFYEG PP-------- --SSGAEAAT TGAAPPMMMM IIVVGRRVYY ITTTTNSLLY SSNNFFFY-G PP-------- --NNGRTFFA AGGGPPMMMM VVIIGRRVYY WTTTTNSLLY SSDDFFFYDG PP-------- --NNGKAFFA AAGGPPMMMM VVIIGRRVYY WTTTTNSLLY SSDDFFFYDG PP-------- --NNGKTFFG GYGGPPMMMM VVIIGRRVYY WTTTTNSLLY SSDEFFFYGD PP-------- --KKNGALLN NGGGPPMMMM VVIIGRRVYY FTTTTNSLLY GGDPFFFYEG PP-------- --TTSAELLN NGGGPPMMMM VVIIGRRVYY FTTTTNSLLY RRDEFFFYDG PP-------- --AASGPLLN NGGGPPMMMM VVVVGRRVYY FSSSSNSLLY AADEFFFYVG VVE-QEELQE PVKKGKRIIP PGGGPPMMMM IILLGRRLYY ATTTTTSLLY SSDKFFFYPD VVE-QEELQE PVKKGKRVVP PGGGPPMMMM IILLGRRLYY VTTTTTSLLY SSDKFFFYPN VVE-QEELQE PVKKGKKVVP PGGGPPMMMM IILLGRRLYY VTTTTTSLLY SSDKFFFYPD VVD-QEELQE PVKKGKQVVA AGGGPPMMMM IILLGRRLYY VTTTTTSLLY SSDKFFFYPD VVE-QEELQE PVKKGKRVVA AGGGPPMMMM IILLGRRLYY ITTTTTSLLY SSDKFFFYPD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVE-EEELQE PVKKGKRVVA AGGGPPMMMM IILLGRRLYY ITTTTTSLLY SSDKFFFYPD VVE-QEELQE PVKKGKRVVP PGGGPPMMMM IILLGRRIYY VTTTTTSLLY SSDKFFFYPD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVE-KDDLQD PIKKGKKVVP PGGGPPMMMM IILLGRRLYY VTTTTNSLLY SSDKFFFYPD VVE-KEELQD PTKKGKIIIP PGGGPPMMMM IILLGRRIYY VTTTTSSLLY SSDKFFFYPD VVG-DGGKQD VEQQGQKLLR RGGGPPMMMM IILLGRRLYY VTTTTNSLLF SSDKFFFYPG VVK-DGGEQD VEQQGKKLLR RGGGPPMMMM IILLGRRLYY VTTTTNSLLF SSDKFFFYPK VVG-DGGNQD VQKKGKSLLR RGGGPPMMMM IILLGRRLYY ATTTTNSLLF SSDRFFFYPE VVG-DGGNQE VQKKGKSLLR RGGGPPMMMM IILLGRRLYY ATTTTNSLLF SSVVFFFYPE VVT-DDDKQS VQKKGHRLLR RGGGPPMMMM IILLGRRIYY VTTTTNSLLF SSDEFFFYQD VVE-EKK-PE AYKKGRKIIE EGGGPPMMMM LLLLGRRLYY VTTTTTSLLY KKDDFFFYPE VVE-DHHDEP AYKKGRQIIE EGGGPPMMMM LLLLGRRLYY VSSSSTSLLY KKDDFFFYPE ---------- ---------- -GGGPPKKKK IILLGRRLYY VTTTTNSFFY SSDKFFFYPN RRN-PEELAE PFKKGRRLLL LGGGPPMMMM LLLLGRRLYY VSSSSSSLLF SSDKFFFYPE NNKEKEELRP AYKKGRRLLE EGGGPPMMMM LLLLGRRLYY VSSSSSSLLY SSDKFFFYPK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMMM VVQQGRRVYY FSSSSSSLLL AAD------- ---------- ---------- ------MMMM VVSSGRRLYY YTTTTSSLLL AAD------- GLLKKGGWMV KLLNAN--PP PSSGDDKKEF FFVDFF---R SSSVRLGGGA SSDSSCYP-- GLLRRGGWMA KVVNVN--PP PEEGEEKKEF FFVDFF---R AAAVRLGGGA STDSSCYP-- GVVPPAAAQV LAAHAG--PP PDDGAADDDY YWVEFF---R AAAIRLGGGC STDSSCYPSV GVVPPGGVEV MAANVG--GG GNNGDDKKDY YFVSFF---R AAAIRLGGGC STDSSCYPSV DRRGGAAAMV MAANVG--EE ENNGDDKKDF FWVDFF---R SSSIRLGGGC STDSSCYPSV GIIDDGGWMV KLLDAG--PP PNNGDDPPKF FFLEWW---R PPPVRLGGGC SSDSSCYP-- GIIKKGGWMV KVVDVN--PP PDDGDDPPNF FFVDFF---R VVVIRLGGGA SSDSSCFP-- GIIRRGGWIA KAAEAD--PP PGGGDDPPGF FFTEVV---R PPPIRLGGGS SSDSSCYPS- DLLIIRREGS VMMLQVVDVV VNNGNNPPNF FLVDFFPGPL AAALRYGGGC SSDIII---- NLLIIRREGS VMMLQIVDAA ANNGNNPPNF FLVDFFPGPL AAALRYGGGC SSDIII---- DLLIIRREGS VMMLQIVDVV VKKGNNPPNF FLVDFFPGPL AAALRYGGGC SSDIIL---- DLLIIRREGS VMMLQIVDVV VKKGNNPPNF FLVDFFPGPL AAALRYGGGC SSDIIL---- DLLIIRREGS VMMLQVVDVV VKKGNNPPNF FLVDFFPGPL AAALRYGGGC SSDIII---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DLLIIRREGS VMMLQVVDVV VKKGNNPPNF FLVDFFPGPL AAALRYGGGC SSDIII---- DLLIIRREGS VMMLQIVDVV VKKGNNPPNF FLVDFFPGPL AAAIRYGGGC TSDIIL---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DMMIIKKEGS VMMLQIVDEE EKKGNNPPNF FLVDFFPGPL AAALRYGGGC SSDIIV---- DLLLLKKEGA VMMLQIVDKK KKKGNNPPNF FLVDFFPGPL AAAIRYGGGC TSDIII---- GLLVVEEKGS HIILQIVDEE EKKGNNPPNF FFVDFFPGPL AAAMRYGGGC TSDIII---- KLLVVEEQGS HIILQIVDEE ENNGNNPPNF FFVDFFPGPL AAAMRYGGGC TSDIII---- ELLMMDDKGS HIIIQIVDEE EKKGNNPPNF FFVDFFPGPL AAAMRYGGGC TSDIII---- EIIMMEEKGS HIIIQIGDEE EKKGNNPPDF FFVDFFPGPL AAAMRYGGGC TSDIII---- DLLVVKKKGS HMMLQIVDEE EKKGNNPPNF FFVDFFPGPL AAAMRYGGGC TSDIII---- EHHVVKKSGA TMMVQVIDEE ESSGNNRRDF FLIDFFEGPL AAAMRYGGGC TSDIII---- ENNVVRRSGA TMMLQIVDII ITTGNNKKNF FLIDFFPGPL AAAMRYGGGC TSDIII---- NVVVVKKEGS VMMLQIVDEE EKKGNNKKNF FLVDFFPGPL AAAIRFGGGS TSDIIA---- EMMVVAAAGG TIIVQLIDEE ENNGNNEENF FLVDFFPGPL PPPMR----- ---------- KMMVVSSQGG HIIVLIVDVV VNNGNNEEDF FLVDFFPGPL PPPMRYGGGC TSDIILANDA ---------- ---------- ---------- ---------- ---------- ---------- -----KKKGK DDDAQYKANN NWWDVVEEDF FAVDFFGG-R AAAMRFSSSL YSS------- -----KKKGK DDDEQFKLYY YWWDKKEEQF FAIDFFKG-R PPPMRFRRRL YAGPPGDGNR ------- ------- KRR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LVVQREE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNNSSSSKKP CRVPTTGGGG GGLLTTRLDM SPRTAQLLLL SSLLPGPPVK AYYAWTFFFF gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -MMRAPTTTT gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FSAILSSSSS SPRSSSSSKK RKKTRSSPLV EISAVQPPSA VVVVQAHPPP GKHHLLPARG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AAE RAEELLVAQP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MGGK EEPPQQFLSG ---------- ---------- ---------- ---------- -----LKQQG CLGGNNLHTY ---------- ---------- ---------- ---------- ---------- ---------- TLPLRPPTTT TPHPPPPPLL PAASPPPPVP LTRVRRNNVP LLLLPPPRRH SLVVMMAAAV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMVLDH ---------- ---------- ---------- ---------- ---------- ----MMVLQH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------KKR REFF-----A ---------- ---------- ---------- ---------- -------KKR FIVVMMALRA ---------- ---IVVPFFR RRPPTTFFFY YYPPMMAMMK PPPDAYVVAA CCYYTTTTGI ---------- ---MAAKLLP PPPPTTFFFY YYPPDDAMMR PPPDAYVVAA AAYYVVVTGV ---------- ----MMSMMP PPPPTTFFFH HHAPLLAMMQ AAAEAYTTLL LLSSPPPFS- ---------- ----MMTMMP PPPPTTFFFH HHAPLLAMME AAANAYTTLL LLSSPPPFS- ---------- ----MMTLLP PPPPTTFFFY YYPALLAMME VVVKAFTTLL MMSSPPPAS- ---------- ---MAATWWP PPPPSSFFFY YYPPLLAAAK PPPTAYVVAA MMDDPPPRK- ---------- ---MVVTWWP PPPPTTFFFY YYPPMMAVVK AAAKAYVVVV RRNNPPPANG ---------- ---MAASWWP PPPPTTFFFY YYPPMMAMMQ RRRRGYVVAA LLDDPPPRE- ---------- ---CTTK--C CCPPGGYYYP PPTLAAMKK- RRREVYLLPP CCYYRRRTGT ---------- ---------- ---------- -------MM- RRREVYLLPP CCYYRRRTGI LLLLPPPGGG -AACGGK--C CCPPGGYYYP PPSLAAMKK- RRREVYLLPP CCYYGGGTGI ---------- ---------- ---------- ------MKK- RRREIYLLPP CCYYRRRTGI ---------- ---CGGN--C CCPPGGYYYS SSTLAAMKK- RRREVYLLPP CCYYRRRTGT MMMRPPPIII ASSCGGN--C CCPPGGYYYS SSTLAAMKK- RRREVYLLPP CCYYRRRTGT ---------- ---CGGN--C CCPPGGYYYS SSTLAAMKK- ---------- ---------T ---------- ---CGGN--C CCPPGGYYYS SSTLAAMKK- RRREVYLLPP CCYYRRRTGT QQQLWWWQQQ EDDCGGD--C CCPPGGYYYP PPTQAAMKK- RRREVYLLPP CCYYRRRTGT CCCTLLLVVV FTTCGGN--C CCPPGGYYYS SSTLAAMKK- RRREVYLLPP CCYYRRRTGT ---------- ---CGGN--C CCPPGGYYYS SSTLAAMKK- RRREVYLLPP CCYYRRRTGT EEETAAAAAA AAACCCHTTK KKPPGGYYYA AATLAAMEEK RRRKVYVVTT CCYYNNNTGI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---CGGS--C CCPPGGYYYK KKSLAAMKK- RRREVYLLPP CCYYRRRTGI GGGVVVVNNN EKKNGGCCCS SSPPGGYYYA AASISSMSS- RRRSIYVVTT AAYYAAATGI AAAVVVVSSS EKKQGGCCCS SSPPGGYYYA AASLAAMSS- RRRTIYVVTT AAYYAAATGI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---RMMLQQG GGPPGGYYYA AATLAAMSS- SSSKIYVVTT AAYYTTTTGI ---MAAAAAA AAACCCGGGT TTPPGGYYYA AATLAAMEEK RRRKLYVVTT CCYYNNNTGI ----MMMSSS PNNCHHG--- --PPGGYYYA AASAAAIKK- RRRELFVVTT AA-----NAA ----MMMPPP ---CHHG--- --PPGGYYYA AASAAAIKK- RRRELFVVTT AA-----HAR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---ESSKCCC CCPPGGYYYA AATLAAVRRN VVVKLYVVVV CCQQPPPLDE ---------- ---------- ---------- ------MRRS RRRKLYTTVV TTQQPPPLDE ---------- ---------- --PPGGLLLI IIT-IILIIS DDDFYFSSNN WWHHGGGIRQ LLLAAAAGGG -AALPPFRRF FFDDEETTTC CCQPMMPKKI QQQEVYVVWW TTGGVVVGMG LLLVSSSGGG LAAAPPAGGR RRDDEETTTC CCAPMMKKKI QQQDVYVVWW TTGGAAAGVG IINNRDDFFI IVDNPKKSEY SSKIIVHLYY IDDEHHHHFA CCCC-NKERR LVPGGLRRSS VVNNADDFFL LVDDPKKSPY GGKVVIYLYY IDDEHHHHFA CCCC-NKERR LVPAALRRSS ----RDDAAL LVDKPGGSSY GGKIIVHMNN TDDEHHHHFS SSSS-LHERR LIPGGLRRSS ----KDDAAL LVDKPGGSPY GGQIIVHMNN KDDEHHHHFA SSSS-LHERR LIPGGLRRSS ----KDDGGL LVDDPTTSEF GGQIIVHMNN KDDEHHHHFA SSSS-LHERR LIPGGIRRSS ----QDDAAI IVDDPAASPY AASIIVGMHH ADDEHHHHFC CCCC-NHERR LVPGGLRRSS GG--KDDAAM MVDDSQQSSF GGQVVVGMYY TGGEHHHHFM CCCC-NHERR LVPDDIRRSS ----RDDAAL LVDDPDDSGY AAQIIVGMNN ADDEHHHHFA CCCC-YHERR LVPGGIRRSS TTEEADDYYL LTDDPKKSPY SSQVVIHMYY LDDEHHHHSC ------DSNN LLPGGLMMSS IIEEADDYYL LTDDPKKSPY SSQVVIHMHH LDDEHHHHSC ------DSDD LLPSSIIISS IIEEADDYYL LTDDPKKSPY CCQVVIHMNN LDDEHHHHSC ------DSTT LLPCCLMMSS IIEEADDYYL LTDDPKKSPY CCQVVIHMHH LDDEHHHHSC ------DATT LLPAALIISS TTEEADDYYL LTDDPKKSPY CCQVVIHMNN LDDEHHHHSC ------DSTT LLPSSLIISS TTEEADDYYL LTDDPKKSPY CCQVVIE--- ---------- ---------- ---------- TTEEADDYYL LTDDPKKSPY CCQVVIHMNN LDDEHHHHSC ------DSTT LLPSSLIISS TTEEADDYYL LTDDPKKSPY CCQVVIHMNN LDDEHHHHSC ------DSTT LLPSSLIISS TTEEADDYYL LTDDPKKSPY SSQVVIHMYY LDDEHHHHSC ------DSNN LLPSSFIISS TTEEADDYYL LTDDPKKSPY CCQVVIHMNN LDDEHHHHSC ------DSTT LLPSSL---- TTEEADDYYL LTDDPKKSPY CCQVVIHMNN LDDEHHHHSC ------DSTT LLPSSLIISS IINNKDDYYL LTDDPSSSPY SSQVVIHVHH IDDKHHHHSC ------DKRR LLPSSLLLSG ---------- ---------- -------MNN TDDEHHHHSC ------DVNN LLPCCLIISS IINNKDDYYL LTDDPKKSPY SSQVVIHMNN VDDEHHHHSC ------DVNN LLPCCLIISS IIEEKDDYYL LTDDPSSSPY SSKVVIHVYY VDDEHHHHTC ------DERR LAPSSLVVSG IIEEKDDYYL LTDDPNNSPY SSKVVIHVYY VDDEHHHHTC ------DQRR LVPGGIVVSG ---------- ---------- -------MFF VDDEHHHHSC ------DDRR LLPSSLIISG IIDDKDDYYL LTDDPSSSPY SSSVVIHMFF VDDEHHHHSC ------DDRR LLPSSLIISG IINNKDDYYL LTDDPNNSPY SSQVVIHVHH VDDEHHHHSC ------DSRR LLPSSLLLSG AADDGDDAAI ITDNPEESDF CCQVVISVHH IDDEHHHHTC ------KKSS LVPCCLNNSD RRDDGDDAAI ITNNPEESEF CCQIIISVNN IDDEHHHHTC ------KKSS LVPCCLNNSD ---------- ---------- ---------- ---------- ---------- MPRKKLSSSG EEEEHDDYYL LTDDPAASPY CCQVVIHTSS KNNEHHHHSC FFFFV-KTDD LLPCCLNNSD EEPPHDDYYL LTDDPEESPY CCQIIVHTRR KDDEHHHHSC YYYYVEKKDD LLPSSLNNSD QQYYDTTDDR RNRVGQQVFG GGSVVLKVVV LDDKLLDDSK ------KGPP MQLSSLDDGK GGDDEDDKKL LTDRPGGSAR GGQVVINVGG -NNEHHHHG- -------DRR FTGGGLDDTN GGDDEDDKKL LTDNPKKSPY GGKVVVNVGG -NNEHHHHS- -------DRR LAGGGLDDTS RIIYIKRPPK KVVIIEEEEE VVKSSSSGYS RHHHTVHGGD IISAGGGNE- -EGGGPPPPG RIIYIKRPPK KIIVVEEEEE AAGTTTTGYT KHHHTVHGGD IISAGGGGP- -DGGGPPPPG RIIYVKTAAK KIIIIEDDDD IIATTTTGYS RHHHTVHGGE IVSTGGGGAG KDGGGAAAAG RIIYIKTAAK KIIIIEEEEE VVKTTTTGYS RHHHTIHGGD IVSTGGGGGG KDGGGPPPPG RIIYIKLAAK KIIIIEEEEE VVATTTTGYS RHHHTIHGGE IVSTGGGGGG EDGGGPPPPG RIIYIKLPPK KVVIIEEEEE LLETTTTGYS RHHHTVHGGG IVTAGGGNA- -EGGGPPPPG HIITIKTPPK KVVIIDNNNN LLETTTTGYA RHHHTVHGGD IISAGGGSP- -EGGGPPPPG RIIHIKRPPK KVVIIEEEEE LLRTTTTGYS RHHHTIHGGD VVSAGGGSP- -EGGGPPPPG RIIYVGRPPK KVVIIESSSS IIACCCCNVS NHHHTSHLLS EMVNLLLGD- -LQQQKKKKS RIIYVGRPPK KVVIIENNNN IIACCCCNLG NHHHTSHLLS EMISLLLGD- -PQQQKKKKG RIIYVGRPPK KVVIIEEEEE IIACCCCGLG YHHHTSHLLS EMISLLLGD- -SKKKKKKKG RIIYVGRPPK KVVIIEKKKK IITCCCCNLG FHHHTSHLLS EMVSLLLGD- -PEEEKKKKG RIIYVGRPPK KVVIIEEEEE IIACCCCELA FHHHTSHLLS EMISLLLGD- -VKKKKKKKG ---------- ------KKKK IIACCCCELA FHHHTSHLLS EMISLLLGD- -VKKKKKKKG RIIYVGRPPK KVVIIEKKKK IIACCCCELA FHHHTSHLLS EMISLLLGD- -VKKKKKKKG RIIYVGRPPK KVVIIEKKKK IIACCCCELA FHHHTSHLLS EMISLLLGD- -VKKKKKKKG RIIYVGRPPK KVVIIEKKKK IIECCCCGLG THHHTSHLLT EMISLLLGD- -PKKKKKKKG ---------- ---------- ---------- ---------- ---------- ---------- RIIYVGRPPK KVVIIEKKKK IIACCCCELA FHHHTSHLLS EMISLLLGD- -VKKKKKKKG RVVYVARPPK KVVVVEEEEE IIEIIIIGLG FHHHTSHLLS DMISLLLGD- -KEEEAAAAN RIIYVGRPPK KTTVVEYYYY VVWCCCCGLA NHHHTSHLLC EMISIIIGD- -PYYYKKKKG RIIYVGRPPK KTTVVEYYYY VVWCCCCGLA NHHHTSHLLC EMISLLLGD- -PCCCKKKKG RIIYVKRPPK KVVVVDAAAA IIQTTTTGLA YHHHTSHLLS EMISLLLGD- -KDDDEEEEN RVVYVKRPPK KVVVVEEEEE IITTTTTGLA YHHHTSHLLS EMISIIIGD- -KDDDEEEEN RIIYAKRPPK KYYVVDKKKK IIETTTTGLA YHHHTAHLLS ELVSLLLGD- -EEEEKKKKN RIIYAKRPPK KYYVVDKKKK IIDTTTTGLA FHHHTAHRR- ELVSLLLGD- -EEEEKKKKN RVVYVLRPPK KVVVVEEEEE IIETTTTGLG FHHHTSHLLS EMISLLLGD- -KEEEAAAAN RIIYIERIIH HTTIIESSSS LLSNNNN-LS FHHHTSHLLD NMISLLLGE- -ANNNSSSSN RIIYVERIIH HTTIIESSSS LLANNNN-LS FHHHTSHLLD NMISLLLGE- -ADDDSSSSN VEEGKG---- ---------- ---------- ---------- ---------- ---------- RIIFVGRPPK KVVIIE---- VVKAAAADCT AHHHTTHLLN NMISMMMGD- -AEEEKKKK- FIIYIVRPPK KTTIID---- VVKHHHHNVT AHHHTTHLLN NMISMMMGD- -AEEEKKKK- RLLYVLWKKP P--------- LLKLLLLVLA IHHHTADQQN AKQDVVVNE- -SLLLVVVVN RIIFIHSPPK KTTIID---- VVDGGGGGVV GHHHTFFLLG MITGSSSND- -DDDDRRRRA KIIFVHAPPK KTTIIT---- VVKGGGGGVV GHHHTLYLLG MITGSSSNN- -KDDDRRRRA IMLLHYSPPK WIRRGDDDQQ Y--------- ----YDFFWW WLLNEEVSSW WAVVNNNN-- ILLLHDTPPR WVRRGPPPQQ Y--------- ----YDFFWW WLLSGGVTTW WTVVRRRR-- IIMMCETVVR WIRRGPPPQQ D--------- ----YDFFWW WLLRDDYSSW WALLPPPP-- VIMMCETVVR WIRRGPPPQQ T--------- ----YDFFWW WLLRDDYTTW WALLPPPP-- IILLCETIIR YMRRGEEEQQ T--------- ----YDFFWW WLLRDDYSSW WGLLPPPP-- IMLLAQSPPR WVRRGPPPQQ Y--------- ----YDGGWW WLLYDDTTTW WGTTDDDD-- IILLHDNVVR WIRRGDDDQQ Y--------- ----YDFFWW WLLYDDTTTW WGTTRRRR-- VVMMHESPPR WVRRGPPPQQ Q--------- ----YDFFWW WLLYDDTTTW WGTTNNNN-- FLLLGETVVT WKGGGAAASS P--------- ----YDFFWY YPPHNNVSSW WAAANNNN-- FLLLGETVVT WKGGGEEEAA P--------- ----YDFFWY YPPHNNISSW WAAANNNN-- FLLLGETVVT WQGGGAAAAA P--------- ----YDFFWY YPPHNNVSSW WAAANNNN-- FLLLGKTVVT WQGGGAAAAA P--------- ----YDFFWY YPPHNNVSSW WAAANNNN-- FLLLGETVVT WRGGGAAAAA P--------- ----YDFFWY YPPHNNVSSW WAAANNNN-- FLLLGETVVT WRGGGAAAAA P--------- ----YDFFWY YPPHNNVSSW WAAANNNN-- FLLLGETVVT WRGGGAAAAA P--------- ----YDFFWY YPPHNNVSSW WAAANNNN-- FLLLGETVVT WRGGGAAAAA P--------- ----YDFFWY YPPHNNVSSW WAAANNNN-- FLLLGETVVT WRGGGSSSAA P--------- ----YDFFWY YPPHNNVSSW WAAANNNN-- ---------- ---------- ---------- ---------- ---------- ---------- SVLLP-RCC- ---------- ---------- ---------- ---------S SAHHNNNN-- GLLLDSEVVR GNLLFPPPII S--------- ----RTHHLY YNNWGGLSSQ QCCCLLLL-- FLLLGETVVN WAGGEAAAAA P--------- ----YDFFWY YPPHNNVSSW WGAAKKKK-- FLLLGETVVN WVGGESSSAA Q--------- ----YDFFWY YPPHNNVSSW WGAAKKKK-- GLLLDSDVVR WKGGHSSSPP L--------- ----YDFFWY YPPHNNTSSW WGAATTTT-- GLLLDSEVVR WKGGHSSSPP L--------- ----YDFFWY YPPHNNTSSW WGAAKKKK-- GLLLDSDIIR WKGGHSSSPP L--------- ----YDFFWY YPPHKKTSSW WGAAKKKK-- GLLLDSDIIR WKDDISSSPP L--------- ----YHFFWY YPPHKKTSSW WGAAKKKK-- GLLLDSEVVR WKGGHSSSPP L--------- ----YDYYWY YPPHKKTSSW WGAAAAAA-- FLLLGKTPPT WAEEKTTTVV P--------- ----YDFFWY YPPRNNVSSW WGSSNNNN-- FLLLGKTPPT WAGGKVVVVV P--------- ----YDFFWY YPPRNNISSW WGSSNNNN-- ---------- ---------- ---------- ---------- -------SSR RGGGVVVV-- DVEEDKNLLT WRDDRKKKAA L--------- ----YDYYWY YPPFNNVAAW WGAAKKKK-- DILLDSDCCT WKDDKKKKAA L--------- ----YDFFWY YPPFDDVSSW WGAANNNN-- GQTTKHELLK GAQQFEEEEE I--------- ----LSNNHN NGGREEKSSP PDEEIIII-- LEYYDDGVVY WPAADDDDMM QGGAVVVGGA VVVGYDIIRA AIIKNNVTTF FTGGSSSSNY LEYYNAGVVH WPDDGDDDLL RGGAIITGGK YYYGYDVVRA APPKNNLTTF FTGGNNNNNY -TG--LLLLL EHRNRIHHDD DLRKKKKHSS LLLGEENNRR RRRRMAAL-- -----ELRPL -CG--FFFLL ECANKLHHDD DLAKKKRYAA LLLGQEHHRR RRRRMVVL-- -----EVRPL -QG--IIIPP EDKHRLHHDD DLRAAARQTT LLLGAQHHQQ QQQQMAAL-- -----EVRPA -QG--IIIPP EDKHRLHHDD DLRAAARQTT LLLGANHHQQ QQQQMAAL-- -----EVRPA -QG--IIIPP EDKHKIHHKK KLRDDDKQTT LLLGANHHQQ QQQQMAAL-- -----EIRPA -MG--LLLPP DIRRRLHHDD DLTRRRRQEE FFFGDEHHQQ QQQQLVVF-- -----ELRPA -MG--VVVGG DEKHRLHHDD DLYRRRRQTT LLLGAEYYQQ QQQQMAAL-- -----ELRPA -MG--LLLPP QIGRRLHHDD DLRRRRRQAA VVVGEEHHQQ QQQQMVVL-- -----ELRPA -VGFFNNNAA HVLSRIFFDD DWQRRREQTT MMMT--DDGG GGGGLIIP-- -----EIRFL -VGFFNNNAA HVLSHIHHDD DWQRRREQTT MMMK--DDGG GGGGLIIP-- -----EIRFL -VGFFNNNAA DVLSHLHHDD DWQRRREQTT LLLQ--DDGG GGGGLIIP-- -----EIRFL -VGFFNNNAA DVLSHLYYDD DWQRRREQTT LLLQ--DDGG GGGGLIIP-- -----EIRFL -VGFFNNNAA DVLSHLYYDD DWQHHHEQTT LLLK--DDGG GGGGLIIP-- -----EIRFL -VGFFNNNAA DVLSHLYYDD DWQRRREQTT LLLK--DDGG GGGGLIIP-- -----EIRFL -VGFFNNNAA DVLSHLYYDD DWQRRREQTT LLLK--DDGG GGGGLIIP-- -----EIRFL -VGFFNNNAA DVLSHLYYDD DWQRRREQTT LLLK--DDGG GGGGLIIP-- -----EIRFL -VGFFNNNAA DVLKHLHHDD DWQRRREQTT MMMP--DDGG GGGGHIIP-- -----EIRFL ---------- ---------- ---------- ---------- ---------- ---------- -LGSSRRRYY PARGIT---- ---------- ---------- ---------- ---------- -FGAAEEEMM CLGVISCCNN NYIMMMVESS LLLQ--DDQQ QQQQAGGANN NNNNICLRSI -AGFFKKKEE EVMHSLNNDD DWTEEERQTT LLLGE-DDGG GGGGLIIP-- -----EIRFL -AGFFKKKEE DVHHSLNNDD DWTEEERQTT LLLGK-DDGG GGGGLIIP-- -----EIRFL -AGFFDDDQQ HVLRHLTTQQ QLARRREQTT LLLGN-TTGG GGGGLLLP-- -----EIRFL -AGFFNNNQQ HVLRHLHHSS SWPGGGEQTT LLLGD-KKGG GGGGLLLP-- -----EIRFL -AGFFDDDQQ HVLSHLHHSS SWPGGGEQLL LLLGE-TTGG GGGGLLLP-- -----EIRFL -AGFFNNNQQ HVLSHLHHSS SWPGGGEQLL LLLGP-TTGG GGGGLLLP-- -----EIRFL -AGFFDDDQQ HVLRHLHHDD DWPGGGEQTT LLLGS-TTGG GGGGLLLP-- -----EVRFL -HGFFNNNAA HVLNSVHHEE EWDSSSKQTT LLLPQPLLGG GGGGALLP-- -----EVRFL -HGFFNNNAA HVLNSVHHEE EWDTTTKQTT LLLPMPRRGG GGGGALLP-- -----EVRFL -TDEEEEEKK CQLKCKRR-- ---------- ---------- ---------- ---------- -LGYYHHHTT DCQCRLNNRR RWQEEEEQTT LLLGD-DDGG GGGGLTTP-- -----EIRFL -KGWWKKKVV DLQCRLNNKK KWSTTTTQTT LLLGS-DDGG GGGGITTP-- -----EIRFL -MSSSEEEFF LKLQHVAALL L--------- ---------- ---------- ---------- YMGQQMMMQQ DARNTIVVDD DLHTTTQKVV VVVPGAPP-- ---------- -----EIRFP YMGKKMMMAA DPHNTVVVDD DLHTTTQKVV VVVPGAPP-- ---------- -----EIRCA LLLHDDTMFF INMVSKKDLS SIIWLWWFYY -EGWNAAEVV IEIAEL-NNN LLLPPEEIIL LLLHDDTMFF VNVLNKKDLS SIIWLWWFYY -EGWQAAEVV IDIAQF-PPP LLLPPPPVVL AAAHDDVYFF VGVVDTTNLG SIIWTWWWRR -EGFHVVKTT ATIAEADEEE LLLPPPPLLL AAAHDDVYFF VGVVDTTNLA SIIWTWWWRR -EGFHAAETT ATIPEAEKKK LLLPPPPLLL AAAHDDSYFF CGVVDTTNLG AIIFTWWWQQ KDGFEAAKTT ITIPVADDDD LLLPPDDLLL AAAHDDTYFF VNCISKKDLS SIIWTWWYRR -DDWAVVRVV IEIAEADQQQ LLLPPPPVVL AAAHDDTYFF MNCVSKKDLA SIIWLWWYRR -DGWHLLKVV IDIAEADQQQ LLLPPPPIIL AAAHDDAYFF VGVVSEEDLA SVVWLWWHRR -QGWGIIRVV IEIAEADQQQ LLLPPPPLLL LLLHDDSQFF VGCLSNNIQF YKKNEEEG-- ---------- TWSEKIPSSS KKKKKVVKKG LLLHDDDQFF VGCLSNNIQF YKKNEGGG-- ---------- TWSEKIPSSS KKKKKVVKKG LLLHNNDQFF VGCLSTTIQF YKKNQGGG-- ---------- TWSEKIPPPP KKKKKVVKKG LLLHNNDQFF VGCLSTTIQF FKKNEDDG-- ---------- TWSQKIPPPP KKKKKVVKKG LLLHNNDQFF VGCLSTTIQF YKKNEGGG-- ---------- TWSEKIPPPP KKKKKVVKKG LLLHNNDQFF VGCLSTTIQF YKKNEGGG-- ---------- TWSEKIPPPP KKKKKVVKKG LLLHNNDQFF VGCLSTTIQF YKKNEGGG-- ---------- TWSEKIPPPP KKKKKVVKKG LLLHNNDQFF VGCLSTTIQF YKKNEGGG-- ---------- TWSEKIPPPP KKKKKVVKKG LLLHDDAQFF VGCLSTTIQF YKKNEGGG-- ---------- TWSEKIPPPP KKKKKVVKKG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIIHWWNQYY DVVVSSSGRG SDDPDAAY-- ---------- AVVKRLYYYY AAAVVVVAAK LLLHDDDQLL VGCLSTTVFF YKKEKDDG-- ---------- KWAEKIPSSS KKKKKVVEEG LLLHNNDQLL VGCLSSSIFF YKKEKDDG-- ---------- KWAEKIPSSS KKKKKVVEEG LLLHDDATFF VGSLSNNMIF FKKTQDDG-- ---------- SWSELIKPPP LLLKKVVQQN LLLHDDATFF VGSLTNNMIF FKKTQDDG-- ---------- SWNEIIEPPP LLLKKVVQQN LLLHDDSTYY VGSLSNNMIF FKKNSDDD-- ---------- TWSEIIKPPP LLLKKVVEEN LLLHDDSTFF VGSLSNNMIF FKKNSDDE-- ---------- TWSEVIKPPP LLLKKVVEEN LLLHDDSTYY VGCLTNNMVF FKKTADDG-- ---------- SWSEVIKPPP LLLKKVVRRN LLLHEETHFF VGCLGGGIFI HPPVEEENSS ---------- THATLAPSSS KKKKKVVSSG LLLHEETHFF VGCLGAAIFI HPPDEKKNPP ---------- VQTSLAPSSS KKKKKVVEEN ---------- ---------- ---------- ---------- ---------- ---------- LLLHNNRQYY VGCFXXXXXX X--------- ---------- ---------- ---QQGGEEN LLLHNNKEFF VGCLNKKVFF KKKKSDDSDD --------FF EAKVIIKLLL VVVDDTTGGS ---------- ---------- ---------- ---------- ---------- ---------- PPPWGGNYFF STTLTQQLWI YEEDDAAG-- ---------- ------QAAA KKKAAVVAAD AAAWGGAYFF TSTLTQQLWI YEEDGEEG-- ---------- ------QAAA KKKAAVVAAD KPFKAAVVVV PPLLVDDDID SSLDKYLSSL LLWGIGVRQY DSSSNPPFFK VVVLTTTTGK KDFKMMVVVV PPLLVDDDID SSLDRYVSSL LLWGLGLRQY DTTTNPPHHQ RRRLAAAAGR QGFGAAVVVV PPLLVDDDID SSLDRYVSSC CCWGTGMRQY DSSSDPPHHN VVVLAAAAGS QGFGAAVVVV PPLLVDDDID SSMDRYVSSC CCWGTGMRQY DSSSDPPRRK KKKLAAAAGS KGFGAACCCC PPLLVDDDID SSLDKYVAAC CCWGLGMHQY DSSSDPPMMN VVVLTTTTGK KGFKAAVVVV PPLLVDDDID SSMDRYVSSC CCWGTGLLQY DSSSDPPFFE KKKLTTTTGK KPFKAAVVVV PPLLVDDDIN SSVDRYVSSC CCWGTGLHQY DSSSDPPFFN RRRLTTTTGK KDFGAAVVVV PPLLVDDDIN SSLDRYVSSC CCWGTGLRQY DSSSDPPFFN RRRHTTTTGS WMLPEEMMMM PGLLIDDDIL SSLDRYFSSN NNWLHGIRQY DSSSNPPQQK RRRLTTTTGQ WMLPEEMMMM PGLLIDDDIL SSLDRYFSSN NNWLHGIRQY DSSSNPPKKK RRRLTTTTGQ WMLPEEMMMM PGLLIDDDIL SSLDRYFSSN NNWLHGLRQY DSSSDPPQQR RRRLTTTTGQ WMLPEEMMMM PGLLIDDDIL SSLDHYFSSN NNWLHGIRQY DSSSDPPQQR RRRLTTTTGQ WLLPEEMMMM PGLLIDDDIL SSLDRYFSSN NNWLHGLRQY DSSSDPPQQR RRRLTTTTGQ WLLPEEMMMM PGLLIDDDIL SSLDRYFSSN NNWLHGLRQY DSSSDPPQQR RRRL------ WLLPEEMMMM PGLLI----- ---------- ---------- ---------- ---------- WLLPEEMMMM PGLLIDDDIL SSLDRYFSSN NNWLHGLRQY DSSSDPPQQR RRRLTTTTGQ WMLPEEMMMM PGLLIDDDIL SSLDRYFNNN NNWLHGMRQY DSSSDPPKKR RRRLVVVVGQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FGVVSSLLLL SNEEFPPPAW FFFSLIFLLS SS-------- ---------- ---------- WALPEEMMMM PGLLIDDDIL SSLDRYFSSN NNWLHGIRQY DTTTDPPRRN KKKLVVVVGQ WPMPEEMMMM PGLLIDDDIL SSLDRYFSSN NNWLHGIRQY DTTTDTTRRN KKKLVVVVGQ WILPEEMMMM PGLLIDDDFL SSLDRYFVVN NNWLHGIRQY NEEEDLLKKN VVVLTTTTGQ WFLPEEMMMM PGLLIDDDFL SSLDRYFVVN NNWLHGIRQY NEEEDVVKKN KKKLTTTTGQ WILPEEMMMM PGLLIDDDFL SSLDRYFVVN NNWLHGIRQY NEEEDPPKKN VVVLTTTTGQ WILPEEMMMM PGLLIDDDFL SSLDRYFVVN NNWLHGIRQY NEEEDPPKKN VVVLTTTTGQ WILPEEMMMM PGLLIDDDFV SSLDRYLVVN NNWLHGIRQY NEEEDPPAAK VVVLAAAAGQ WALPEEMMMM PALLIDDDIL SSMDRYVSSC CCWLHGIRQY DSSSDPPLLK KKKLNNNNSQ WALPDDMMMM PALLIDDDIL SSMDRYVSSC CCWLHGIRQY DSSSDPPKKN KKKLNNNNSQ ---------- ---------- ---------- ---------- ---------- ---------- GEIEMMMMMM GGMMMDDDIL SSLDRYFSSN NNWRHGVRQY DSSSDRRAAN RRRLTTTTGQ GVAEDDMMMM GGMMIDDDII SSLDRYVNNC CCWRHGVRQY DTTTDPPEEN KKKLTTTTGQ ---------- ---------- ---------- ---------- ---------- ---------- IGNPAADDDD IPLLPDDDIS AAADQWINNS SSFMDGTRLF DSSSDPPHHK FFFQIIIIYE IGEPAAKKKK VPLLPDDDIS SSNDSWVNNT TTFMDGTRLF DSSSDPPHHH RRRQVVVVYE KLLGGGIFRH ---------- ---------- -GGGHHTGAA PPQQEDGGRR RVVVNNNNSS RIIGGGLYRH ---------- ---------- -GGGAATGAA PPQQSDGGRR RVVINNNNSS SIIGGGIARH ---------- ---------- -GGGRRAGGG PPQQEDGGRR RVVWNNNNSS SIIGGGIARH ---------- ---------- -GGGKKAAGG PPQQEDGGRR RVVWNNNNSS KIIGGGIVKH ---------- ---------- -GGGKKGYGG PPQQEDGGKR RVVWNNNNSS KIIGGGIVRH GGG------- ---------- ANNNGGNGGG PPQQEDGGRR RVVFNNNNSG KIIGGGIVRH ---------- ---------- ASSSAANGGG PPQQEDGGRR RVVFNNNNSR SLLGGGIVKH ---------- ---------- -SSSGGNGGG PPQQEDGGRR RVVFNNNNSA QLLGGGSIRS QQQVLEQQEE LTQQPPEPLL VGGGKKPGGG PPQQQDGGKR RLLATTTTSS QLLGGGSIKS QQQVLEQQEE LTQQPPEPLL VGGGKKPGGG PPQQQDGGKR RLLVTTTTSS QLLGGGSIKP QQQVLEQQEE LKQQPPEPLL VGGGKKPGGG PPQQQDGGKR RLLVTTTTSS QLLGGGSIKP QQQVLDQQEE LDQQPPEPLL VGGGKKAGGG PPQQQDGGKR RLLVTTTTSS QLLGGGSIKP QQQVLEQQEE LKQQPPEPLL VGGGKKAGGG PPQQQDGGKR RLLITTTTSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QLLGGGSIKP QQQVLEEEEE LKQQPPEPLL VGGGKKAGGG PPQQQDGGKR RLLITTTTSS QLLGGGSIKP QQQVLEQQEE LKQQPPEPLL VGGGKKPGGG PPQQQDGGKR RIIVTTTTSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QLLGGGSIRP TTTVLEKKDD LEQQPPDPVV VGGGKKPGGG PPQQQDGGKR RLLVNNNNSS QLLGGGSIRP TTTVLEKKEE LEQQPPDPVV VGGGKKPGGG PPQQQDGGKR RIIVSSSSSS QVVGGGLIKP AAAAIGDDGG KTQQSSDVPP IGGGQQRGGG PPQQQDGGKR RLLVNNNNSS QAAGGGLIKP VVVAVKDDGG ETQQSSDVPP IGGGKKRGGG PPQQQDGGKR RLLVNNNNSS QVVGGGLLKP KKKAVGDDGG NSQQFFDVPP IGGGKKRGGG PPQQQDGGKR RLLANNNNSS QVVGGGLLKP KKKAVGDDGG NTQQFFEVPP IGGGKKRGGG PPQQQDGGKR RLLANNNNSS QAAGGGLLKE VVVYVTDDDD KEQQYYSVPP VGGGHHRGGG PPQQQDGGKR RIIVNNNNSS QIIGGGSVTN KKKVLEEEKK --PPIIEALL VGGGRREGGG PPQQQDGGKR RLLVTTTTSK QIIGGGSIST KKKVLEDDHH D-EEIIPALL VGGGRREGGG PPQQQDGGKR RLLVTTTTSK ---------- ---------- ---------- -------GGG PPAAQDGGKR RLLVNNNNSS QLLGGGAIRP RRRVLNPPEE LKAAPPEPVV LGGGRRLGGG PPQQQDGGRR RLLVSSSSSS QLLGGGAISP VVVIVKKKEE LKRRPPPARR VGGGRREGGG PPQQQDGGKR RLLVSSSSSS ---------- ---------- ---------- ---------- ---------- ---------- EIIDDRQV-- ---------- ---------- ---------- ----SDGGKR RVVFSSSSSA EIIGGAQV-- ---------- ---------- ---------- ----SDGGQR RLLYSSSSSA DQYWWVLLLL NAANNN--PP SSGGGGIIKE EEFFVDE--- AAHQVVRLSD AASSSSSSD- NQYWWAVVVV NVVNNN--PP EEGGGGLLKE EEFFVDR--- AAHQVVRLWD AASSSSTTD- DQYAAVAAAA HAAGGG--PP DDGGGGLLDD DDWWVED--- YYHQIIRLED CCSSSSTTDS DQYVVVAAAA NVVGGG--GG NNGGGGLLKD DDFFVSD--- YYHQIIRLED CCSSSSTTDS DQYAAVAAAA NVVGGG--EE NNGGGGLLKD DDWWVDA--- YYHQIIRLED CCSSSSTTDS DQYWWVLLLL DAAGGG--PP NNGGGGFFPK KKFFLEK--- HHHQVVRLQD CCSSSSSSD- DQYWWVVVVV DVVNNN--PP DDGGGGFFPN NNFFVDE--- QQHQIIRLQD AASSSSSSD- DQYWWAAAAA EAADDD--PP GGGGGGLLPG GGFFTED--- LLHQIIRLED SSSSSSSSDS DQYEESMMMM LQQVVVDTVV NNGGGGLLPN NNLLVDKPLP AAHELLRYPD CCSSSSSSD- DQYEESMMMM LQQIIIDTAA NNGGGGLLPN NNLLVDKPLP AAHELLRYPD CCSSSSSSD- DQYEESMMMM LQQIIIDTVV KKGGGGLLPN NNLLVDKPLP AAHELLRYPD CCSSSSSSD- DQYEESMMMM LQQIIIDTVV KKGGGGLLPN NNLLVDKPLP AAHELLRYPD CCSSSSSSD- DQYEESMMMM LQQVVVDTVV KKGGGGLLPN NNLLVDKPLP AAHELLRYPD CCSSSSSSD- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DQYEESMMMM LQQVVVDTVV KKGGGGLLPN NNLLVDKPLP AAHELLRYPD CCSSSSSSD- DQYEESMMMM LQQIIIDTVV KKGGGGLLPN NNLLVDKPLP AAHEIIRYPD CCTTTTSSD- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DQYEESMMMM LQQIIIDTEE KKGGGGLLPN NNLLVDKPGP VVHELLRYPD CCSSSSSSD- DQYEEAMMMM LQQIIIDTKK KKGGGGLLPN NNLLVDKPDP VVHEIIRYPD CCTTTTSSD- DQYKKSIIII LQQIIIDTEE KKGGGGIIPN NNFFVDAPDP AAHEMMRYPD CCTTTTSSD- DQYQQSIIII LQQIIIDTEE NNGGGGIIPN NNFFVDAPDP SSHEMMRYPD CCTTTTSSD- DQYKKSIIII IQQIIIDTEE KKGGGGIIPN NNFFVDDPEP AAHEMMRYPD CCTTTTSSD- VSYKKSIIII IQQIIIDTEE KKGGGGIIPD DDFFVDDPDP SSHEMMRYPD CCTTTTSSD- DQYKKSMMMM LQQIIIDTEE KKGGGGIIPN NNFFVDAPEP SSHEMMRYPD CCTTTTSSD- DQYSSAMMMM VQQVVVNPEE SSGGKKIIRD DDLLIDKEGP YYHEMMRYPD CCTTTTSSD- DQYSSAMMMM LQQIIIDPII TTGGHHIIKN NNLLIDKPGP YYHEMMRYPD CCTTTTSSD- DQYEESMMMM LQQIIIDTEE KKGGGGVVKN NNLLVDKPNP CCHDIIRFPD SSTTTTSSD- DQYAAGIIII VQQLLLDVEE NNGGGGLLEN NNLLVDGPYP GGHEMMR--- ---------- DQYQQGIIII VLLIIIDTVV NNGGGGLLED DDLLVDNPYP SSHEMMRYPD CCTTTTSSDD ---------- ---------- ---------- ---------- ---------- ---------- D--KKKDDDD AQQYYYLYNN WWDDGGLLED DDAAVDEGL- --HIMMRFGA LLYYYYSSS- D--KKKDDDD EQQFFFLYYY WWDDGGLLEQ QQAAIDAKL- --HQMMRFGA LLYYYYAAGN ------- ------- VKKK--- V------ V------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- A------ ------- ------- RLLLARR 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NSSKKAAPSA CRRTTVVPPP TTTLLLARRL ADDGGGAMPT TQQLLLSLTT PPGSSPPPPV gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRRIAYEAWS SIQVLSRSSS EKKKGGGRVV LVVVESAAVV AQVVVPPSQQ VQWAHWWWLP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------E ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MGGGLK ---------- ---------- ---------- ---------- ---------- --LLKNNNSG ---------- ---------- ---------- ---------- ---------- ---------- -----MGRAP PLNNRPHPPP NLLLAAAPHH VPPPLRVVRR PRTIINNVPP LPCPPHHHAH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MR ---------- ---------- ---------- ---------- ---------- --------MR ---------- ---------- ----MAAAVP PFFYPSPKKK MMAMKKKKAP PEEEEDACCL ---------- ---------- --------AK KFFYPTPRRR DDAMRRRRAP PEEEEDAAAL ---------- ---------- --------MS SFFHASPEEE LLAMQQQQAA AEEEEELLLL ---------- ---------- --------MT TFFHASPKKK LLAMEEEEAA AEEEENLLLL ---------- ---------- --------MT TFFYPSAKKK LLAMEEEEGV VEEEEKLMML ---------- ---------- --------AT TFFYPSPRRR LLAAKKKKAP PEEEETAMMF ---------- ---------- --------VT TFFYPSPRRR MMAVKKKKAA AEEEEKVRRL ---------- ---------- --------AS SFFYPSPKKK MMAMQQQQAR REEEERALLL ---------- ---------- ----TKKKTK KYYPTPLEEE AAMK----GR REEEEEPCCI ---------- ---------- ---------- ---------- ---M----GR REEEEEPCCI GGAAVVLIIA PAARPGGGG- -AAATQQQGK KYYPSPLEEE AAMK----GR REEEEEPCCI ---------- ---------- ---------- ---------- --MK----GR REEEEEPCCI ---------- ---------- ----TKKKGN NYYSTPLEEE AAMK----GR REEEEEPCCI RGAFTTLQQS VAAQPIIIIA ASSSTKKKGN NYYSTPLEEE AAMK----GR REEEEEPCCI ---------- ---------- ----TKKKGN NYYSTPLEEE AAMK----G- ---------- ---------- ---------- ----TKKKGN NYYSTPLEEE AAMK----GR REEEEEPCCI EGHTAAQPPW FLLSWQQQQE EDDDTKKKGD DYYPTPQEEE AAMK----GR REEEEEPCCI CFDQTTNTTE LHHTLVVVVF FTTTTKKKGN NYYSTPLEEE AAMK----GR REEEEEPCCI ---------- ---------- ----TKKKGN NYYSTPLEEE AAMK----GR REEEEEPCCI SLQHIIMEEG AAAAAAAAAA AAAAKTTTCH HYYATPLEEE AAMEKKKKGR REEEEKTCCV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----AKKKGS SYYKSPLDDD AAMK----GR REEEEEPCCI ------MAAT VLLDVNNNNE EKKK-VVVGC CYYASPIEEE SSMS----GR REEEESTAAV ------MGGT VLLQVSSSSE EKKKNQQQGC CYYASPLEEE AAMS----GR REEEETTAAV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------ML LYYATPLAAA AAMS----GS SEEEEKTAAV ---------- ----AAAAAA AAAAAAAACG GYYATPLEEE AAMEKKKKGR REEEEKTCCV ---------- ----MSSSSP PNNNLKKKHG GYYASPADDD AAIK----GR REEEEETAAP ---------- ----MPPPP- ----LKKKHG GYYASPADDD AAIK----GR REEEEETAAP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MSSSSK KYYATPLDDD AAVRNNNNGV VEEEEKVCCV ---------- ---------- ---------- ---------- --MRSSSSGR REEEEKVTTV ---------- ---------- ---------- -LLIT--DDD IILISSSSLD DRRRRFNWWL RG-------- ----AGGGG- -AAAMGGGPF FTTCQSPYYY MMPKIIIITQ QEEEEEWTTL FSGPSSMHHF ALLRSGGGGL LAAALAAAPA ATTCASPYYY MMKKIIIITQ QEEEEDWTTL YTTRADDFII VDDPKETYYS IIHKVLYNEE HHHHFGNACS AALCPG--KK PIERRFLIVP YVTAPDDFLL VDDPKPTYYG VVYKLLYGEE HHHHFGNACS AAYCPA--KK PLERRYLIVP SPFRPDDALL VDDPGSTYYG IIHTVMNGEE HHHHFGNACS SSLSPTGGHH ALERRFLIIP SPFKPDDALL VDDPGPTYYG IIHTVMNGEE HHHHFGNACS AALSPAGGHH AIERRYLIIP SPAKPDDGLL VDDPTEKFFG IIHQLMNGEE HHHHFGNACS AALSPTGGHH ALERRYLIIP DPRQPDDAII VDDPAPRYYA IIGQVMHGEE HHHHFGNACS CCLCPAPPHH PMERRYLVVP NPAKPDDAMM VDDSQSTFFG VVGVTMYGEE HHHHFGNACS MMLCPAPPHH PVERRYLVVP DPRRPDDALL VDDPDGTYYA IIGRVMNAEE HHHHFGNACS AALCPAPPHH PVERRYLIVP YRTAPDDYLL TDDPKPQYYS VVHRLMYKEE HHHHSGNTCS CC---FGGDD SKSRRKLILP YRTAPDDYLL TDDPKPHYYS VVHRLMHKEE HHHHSGNTCS CC---FGGDD SKSRRKLILP YGTAPDDYLL TDDPKPQYYC VVHRLMNREE HHHHSGNACS CC---FGGDD SKSRRKLMLP YRTAPDDYLL TDDPKPQYYC VVHRLMHKEE HHHHSGNTCS CC---YGGDD IKARRKLVLP YRTAPDDYLL TDDPKPQYYC VVHRLMNKEE HHHHSGNTCS CC---FGGDD SKSRRKLVLP YRTAPDDYLL TDDPKPQYYC VVE------- ---------- ---------- ---------- ---APDDYLL TDDPKPQYYC VVHRLMNKEE HHHHSGNTCS CC---FGGDD SKSRRKLVLP YRTAPDDYLL TDDPKPQYYC VVHRLMNKEE HHHHSGNTCS CC---FGGDD SKSRRKLVLP YRTAPDDYLL TDDPKPQYYS VVHRLMYKEE HHHHSGNTCS CC---FGGDD SKSRRKLVLP YRTAPDDYLL TDDPKPQYYC VVHRLMNKEE HHHHSGNTCS CC---FGGDD SKSRRKLVLP YRTAPDDYLL TDDPKPQYYC VVHRLMNKEE HHHHSGNTCS CC---FGGDD SKSRRKLVLP YNTKLDDYLL TDDPSPTYYS VVHRLVHGKK HHHHSGNSCS CC---HGGDD PAKRRFLILP ---------- ---------- -----MNNEE HHHHSGNTCS CC---YGGDD AKVRRKLILP YRTKPDDYLL TDDPKPSYYS VVHRLMNNEE HHHHSGNTCS CC---YGGDD SKVRRKLILP YATKPDDYLL TDDPSPTYYS VVHRLVYGEE HHHHTGNSCS CC---HGGDD PAERRFLIAP YATKPDDYLL TDDPNPTYYS VVHRLVYGEE HHHHTGNSCS CC---HGGDD PAQRRFLIVP ---------- ---------- -----MFGEE HHHHSGNSCS CC---HGGDD AADRRYLVLP YTTKPDDYLL TDDPSPSYYS VVHRLMFGEE HHHHSGNSCS CC---HGGDD AVDRRYLVLP YNTKPDDYLL TDDPNPTYYS VVHRLVHGEE HHHHSGNACS CC---HGGDD PASRRFLILP --NGPDDAII TDDPEDTFFC VVSRVVHGEE HHHHTGNACS CC---HDDKK PEKRRHLIVP --HGPDDAII TNNPEETFFC IISRVVNGEE HHHHTGNACS CC---HDDKK PEKRRHLIVP ---------- ---------- ---------- ---------- ---------- ------MVPR QPLHGDDYLL TDDPAPTYYC VVHRTTSHEE HHHHSGNTCS CCHFPGGGKK EPTRRRLVLP QPLHGDDYLL TDDPEPTYYC IIHRTTRGEE HHHHSGNACS CCYYDSSSKK TPKRRRLVLP HGIDITTDRR NRRGQFLGGG VVKDGVVEKK LLDDSQTPRI KK----GGKK RQGGGQMLQL GVGEQDDKLL TDDPGATRRG VVNSVVGREE HHHHGGSA-- ---------- --DRRFFWTG GAGEQDDKLL TDDPKPQYYG VVNTLVGREE HHHHSDTD-- ---------- --DRRYLWAG GLSRIIIDTT KPREPKIIIK VEEPPPEEVV GYYYSRLVCG PPDDDDAAIY YIILE----- ALSRIIVDTT KPRRPAVAAK IEEPPPEVAR GYYYTKYVCG PPDDDDAAIY YIILP---RR GLSRIVIDTT KPTQARIHHK IEEPPPDEIK GYYYSRPVCG PPEEEEGGIY YVVLAGGKTT GLSRIIIDTT KPTKAKIHHK IEEPPPEEVK GYYYSRPICG PPDDDDGGIY YVVLGGGKTT GISRIIVDVV K-LKAKIHHK IEEPPPEEVK GYYYSRPICG PPEEEEGGIY YVVLGGGETT GLSRIILDTT KPLKPFLAAK VEEPPPETLR GYYYSRPVCG PPGGGGGGIY YVVLA----- DISHIILDTT KPTQPKVVVK VDDPPPNELR GYYYARPVCG PPDDDDGGIY YIILP----- GISRIIVDTT KPREPRIVVK VEEPPPEELR GYYYSRPICG PPDDDDGGVY YVVLP----- GLSRIVVDVV GSRAPKLHHK VEEAAASEIK NVVVSNTSCL AASSSSGGEV VMMTD---GG SISRIVVDVV GSRAPKLHHK VEEPPPNEIK NLLLGNLSCL AASSSSGGEV VMMSD---GG CLSRIVVDVV GSRAPKLHHK VEEAAAEDIK GLLLGYVSCL AASSSSGGEV VMMTD---GG ALSRIVVDVV GTRAPKLHHK VEEPPPKDIK NLLLGFFSCL PPSSSSGGEV VMMTD---GG SLSRIVVDVV GSRAPKLHHK VEEPPPEDIK ELLLAFLSCL AASSSSGGEV VMMSD---GG ---------- ---------- ---PPPKDIK ELLLAFLSCL AASSSSGGEV VMMSD---GG SLSRIVVDVV GSRAPKLHHK VEEPPPKDIK ELLLAFLSCL AASSSSGGEV VMMSD---GG SLSRIVVDVV GSRAPKLHHK VEEPPPKDIK ELLLAFLSCL AASSSSGGEV VMMSD---GG SFSRIVVDVV GTRAPKLHHK VEEAAAKDIK GLLLGTPSCL PPTTTTGGEV VMMTD---GG SL-------- ---------- ---------- ---------- ---------- ---------- SLSRIVVDVV GSRAPKLHHK VEEPPPKDIK ELLLAFLSCL AASSSSGGEV VMMSD---GG SLGRVVVDTT ATRTPSLHHK VEESSSEDIN GLLLGFPSCL AASSSSGGDI IMMCD---GG CLSRIVVDVV GTRAPRIHHK TEEPPPYEVK GLLLANLSCL GGCCCCGGEI IMMSD---GG CLSRIVVDVV GSRAPRIHHK TEEPPPYEVK GLLLANPSCL GGCCCCGGEI IMMSD---GG SLGRIVIDTT KTRSPSLHHK VDDPPPADIK GLLLAYPSCL AASSSSGGEL LMMCD---GG GIGRVVIDTT KTRAPSLHHK VEEPPPEDIK GLLLAYPSCL AASSSSGGEI IMMCD---GG SLGRIAIDTT KERAPSLYYK YDDPPPKEIK GLLLAYPACL AASSSSGGEI ILLCD---GG SLGRIAIDTT KERAPSLYYK YDDPPPKEIK GLLLAFPACR TT----GGEI ILLCD---GG SLGRVVVDTT LKRAPALHHK VEEAAAEDIK GLLLGFPSCL AASSSSGGEI IMMCD---GG CLDRIIINVV ENRKIYLEEH TEEPPPSKLL -LLLSFPSCL AADDDDGGNI IMMTE---GG CLDRIVINVV ENREIYLQQH TEEPPPSKLL -LLLSFPSCL AADDDDGGNI IMMTE---GG KLGVEKVFVV GG-------- ---------- ---------- ---------- ---------- CLDRIVIDTT GTRAPKLAAK VEEGGG-DVG DCCCTAPTCL PPNNNNGGNI IMMID---GG SLDFIILDVV VTRKPEIVVK TDDGGG-DVS NVVVTAPTCL AANNNNGGNI IMMVD---GG SLKRLVTTSS LYWDKQFYYP -------DLF VLLLAISAYQ PPNNNNTTAL LKKGE---SS GLNRIIFDVV HSSNPKLHHK TDDTTT-FVS GVVVVGPFAL PPGGGGSSMM MIILD---HH GLSKIVFDVV HSARPVLSSK TTTDDD-FVS GVVVVGPLAL PPGGGGRRML LIILN---HH --PPPGIIIM MMMLDDHYFE ELGGKWEEII DRRRRGQYY- ---------- ----LAYDDN RRPPPGIIIL LLLLDDHDFE EIGGRWEEVV YRRRRGQYY- ---------- ----FAYDDN TTAAAPIIII IIIMDDCEFD DLGGRWEEII DRRRRGQDD- ---------- ----KHYDDN TTPPPPVVVI IIIMDDCEFE ELGGRWEEII DRRRRGQTT- ---------- ----LHYDDN TTPPPPIIII IIILDDCEFE ELGGRYEEMM DRRRRGQTT- ---------- ----KHYDDN --PPPGIIIM MMMLDDAQFE ELGGRWEEVV ERRRRGQYY- ---------- ----FAYDDH --PPPGIIII IIILDDHDLE ELGGRWEEII DRRRRGQYY- ---------- ----LHYDDH --PPPGVVVV VVVMDDHEFD DLGGRWEEVV ERRRRGQQQ- ---------- ----LAYDDH GGKKKGFFFL LLLLDDGEFE EKGGTWEEKK PGGGGGSPP- ---------- ----MGYDDQ GGKKKGFFFL LLLLDDGEFE EKGGTWEEKK PGGGGGAPP- ---------- ----MGYDDQ GGKKKGFFFL LLLLDDGEFE EKGGTWEEQQ PGGGGGAPP- ---------- ----MGYDDQ GGKKKGFFFL LLLLDDGKFE EKGGTWEEQQ PGGGGGAPP- ---------- ----LGYDDQ GGKKKGFFFL LLLLDDGEFE EKGGTWEERR PGGGGGAPP- ---------- ----SGYDDQ GGKKKGFFFL LLLLDDGEFE EKGGTWEERR PGGGGGAPP- ---------- ----LGYDDQ GGKKKGFFFL LLLLDDGEFE EKGGTWEERR PGGGGGAPP- ---------- ----LGYDDQ GGKKKGFFFL LLLLDDGEFE EKGGTWEERR PGGGGGAPP- ---------- ----LGYDDQ GGKKKGFFFL LLLLDDGEFE EKGGTWEERR PGGGGGAPP- ---------- ----MGYDDQ ---------- ---------- ---------- ---------- ---------- ---------- GGKKKDSSSV VVVLLLP-LE ESGG------ ---------- ---------- ---------- GGAAAGGGGL LLLLLLDSFN NKGGRGSSNN RLLLLFISS- ---------- ----KERTTE GGKKKGFFFL LLLLDDGEFE EKGGNWEEAA EGGGGEAPP- ---------- ----FGYDDQ GGKKKGFFFL LLLLDDGEFE EKGGNWEEVV EGGGGEAQQ- ---------- ----FGYDDQ GGEEEGGGGL LLLLLLDSFN NKGGRWEEKK PGGGGHPLL- ---------- ----FGYDDQ GGEEEGGGGL LLLLLLDSFN NKGGRWEEKK PGGGGHPLL- ---------- ----FGYDDQ GGKKKGGGGL LLLLLLDSFN NKNNRWEEKK PGGGGHPLL- ---------- ----FGYDDQ GGKKKGGGGL LLLLLLDSFN NKNNRWEEKK PDDDDIPLL- ---------- ----YGYHHQ GGAAAGGGGL LLLLLLDSFN NKGGRWEEKK PGGGGHPLL- ---------- ----FGYDDQ GGSSSGFFFL LLLLDDGKFE EKGGTWPPAA DEEEEKVPP- ---------- ----FNYDDQ GGSSSGFFFL LLLLDDGKFE EKGGTWPPAA DGGGGKVPP- ---------- ----FNYDDQ ---------- ---------- ---------- ---------- ---------- ---------- GGKKKGDDDV VVVEFFDKFE EVGGTWSSRR GDDDDRALL- ---------- ----CGYDDQ GGKKKGDDDI IIILFFDSFN NIGGTWTTKK GDDDDKALL- ---------- ----CGYDDQ SSVVVLGGGQ QQQTSSKHNG GSAAKGEEAA SQQQQFEII- ---------- ----LQLSSN HHRRRTLLLE EEEYNNDDEY YATTYWMMPP TAAAADMQQA VVVGGDVVVD DGGGYGYDDL HHRRRTLLLE EEEYTTNAEY YATTHWIIPP TDDDDGLRRA ITTGG-YYYD DGGGYDYDDL EVVSSWAPNN N---IDGGG- -KLD--YGNN RRRRHFFWWD RKKKRIIIHL GGNAALL--- GVISSWTPRR R---FEGGG- -SLEGGYGNN KKKKHVVWWD AKRRHLLLYI GGHVVLL--- DYVSSWAPPP P---FNGGG- -VLANNYGHH RRRRHFFWWD RARRNVVVQI GGHAALL--- DYVSSWAPPP P---FNGGG- -VLSNNYGHH RRRRHFFWWD RARRNVVVQI GGHAALL--- DYVSSWGPPP P---FNGGG- -VLSNNYGHH KKKKHFFWWK RDKKNVVVQI GGHAALL--- DTVSSWGPDD D---VDGGG- -VLGAAYGRR RRRRHFFWWD TRRRHLLLQI GGHVVFF--- DTLSSWGPRR R---VSGGG- -LLAGGYGHH RRRRHVVWWD YRRRHLLLQL GGYAALL--- DTVSSWGPNN N---IGGGG- -DLNKKYGRR RRRRHIIWWD RRRRHLLLQL GGHVVLL--- NVVTTWAPNN N---FDGGGF FPE-GGYGSS RRRRFVVWWD QREEIIIIQL TTDIIPP--- NIVTTWAPNN N---FDGGGF FPE-GGYGSS HHHHHVVWWD QREEIIIIQL KKDIIPP--- NVITTWAPNN N---FDGGGF FPE-GGYGSS HHHHHVVWWD QREEIIIIQL QQDIIPP--- NVITTWAPNN N---LDGGGF FPK-GGYGSS HHHHYVVWWD QREEIVVVQL QQDIIPP--- NVITTWAPNN N---LDGGGF FPE-GGYGSS HHHHYVVWWD QHEEIVVVQL KKDIIPP--- NVITTWAPNN N---LDGGGF FPE-GGYGSS HHHHYVVWWD QREEIVVVQL KKDIIPP--- NVITTWAPNN N---LDGGGF FPE-GGYGSS HHHHYVVWWD QREEIVVVQL KKDIIPP--- NVITTWAPNN N---LDGGGF FPE-GGYGSS HHHHYVVWWD QREEIVVVQL KKDIIPP--- NVITTWAPNN N---VNGGGF FPE-GGYGKK HHHHHVVWWD QREEIVVVQL PPDIIPP--- ---------- ---------- ---------- ---------- ---------- ---------- ---AASASNN N---RTGGGS SDS-SSVAGG IIII------ ---------- ---------- GLWWWQCSLL L---YTGGGA ALT-SSVHVV IIIICLLDDN IMVVIDDDEL QQDGGAANNP NVITTWGPKK K---FLGGGF FMQ-GGYGHH SSSSNVVWWD TERRRIIIQI GGDIIPP--- NVITTWGPKK K---FLGGGF FMQ-GGYGHH SSSSNVVWWD TERRLVVVQI GGDIIPP--- NTITTWGPTT T---FKGGGF FLA-GGYGRR HHHHTCCIIQ AREELRRRQL GGTLLPP--- NTITTWGPKK K---FQGGGF FLA-GGYGRR HHHHHVVYYS PGEEIKKKQL GGKLLPP--- KTITTWGPKK K---FKGGGF FLA-GGYGSS HHHHHVVYYS PGEEMKKKQI GGTLLPP--- KTITTWGPKK K---FKGGGF FLA-GGYGSS HHHHHVVYYS PGEEIKKKQI GGTLLPP--- KTISSWGPAA A---FTGGGF FLQ-GGYGRR HHHHHVVYYD PGEELKKKQL GGTLLPP--- NVITTWGPNN N---IKGGGF FPG-GGYGNN SSSSHIIFFE DSKKYLLLQI PPLLLPP--- NIITTWGPNN N---IKGGGF FPP-GGYGNN SSSSHIIFFE DTKKHLLLQI PPRLLPP--- ---IIRGPVV V---VRDDDE ELP-PPVIKK CCCCRVVYY- ---------- ---------- NVVSSWGPKK K---FRGGGY YPDRTTYGCC RRRRNFFYYR QEEELFFFQI GGDTTPP--- DVVSSWGPNN N---WRGGGW WNEMSSYGCC RRRRNFFYYK STTTLYYYQI GGDTTPP--- EKEDDPDPII I---AESSSS SSKGPPKPQQ HHHHAEEVVL ---------- ---------- NVLSSFTWSS SNYYMFGGGQ QLEMKKFGNN TTTTVQQWWD HTQQPKKKKF PPP------- NLVSSFTWNN NNYYMFGGGK KLEMKKFGNN TTTTVTTWWD HTQQPKKKKF PPP------- --RRLHPTKK KMMGINNMSL LLKKDDDLIW LLWWFF-DKK WNNKVIIPPP PAPLGGGG-N --RRLHPTKK KMMGVNNVNT TTKKDDDLIW LLWWFF-DKK WQQRVIIEEE EAPFGGGG-P --RRAHPVRR RYYGVGGVDT TTTTNNNLIW TTWWWW-GKK FHHKTAIPPP PAPAAAAADE --RRAHPVRR RYYGVGGVDT TTTTNNNLIW TTWWWW-GKK FHHKTAIPPP PPPAKKKKEK --RRAHPSKK KYYGCGGVDT TTTTNNNLIF TTWWWWKDTT FEEKTIIDDD DPPAAAAADD --RRAHPTKK KYYGVNNCSL LLKKDDDLIW TTWWYY-KKK WAAKVIIPPP PAAAPPPPDQ --RRAHPTKK KYYGMNNCSL LLKKDDDLIW LLWWYY-NSS WHHKVIIPPP PAPAEEEEDQ --RRAHPARR RYYGVGGVSL LLEEDDDLVW LLWWHH-NSS WGGKVIIPPP PAPAPPPPDQ --RRLHPSAA AQQGVGGCSS SSNNIIIQKN EEEEGG---- -----TSVVV VEVIVVVVPS --RRLHPDAA AQQGVGGCSS SSNNIIIQKN EEGGGG---- -----TSVVV VEVIVVVVPS --RRLHPDAA AQQGVGGCSS SSTTIIIQKN QQGGGG---- -----TSVVV VEVIVVVVPP --RRLHPDAA AQQGVGGCSS SSTTIIIQKN EEDDGG---- -----TSAAA AQVIVVVVPP --RRLHPDAA AQQGVGGCSS SSTTIIIQKN EEGGGG---- -----TSVVV VEVIVVVVPP --RRLHPDAA AQQGVGGCSS SSTTIIIQKN EEGGGG---- -----TSVVV VEVIVVVVPP --RRLHPDAA AQQGVGGCSS SSTTIIIQKN EEGGGG---- -----TSVVV VEVIVVVVPP --RRLHPDAA AQQGVGGCSS SSTTIIIQKN EEGGGG---- -----TSVVV VEVIVVVVPP --RRLHPAAA AQQGVGGCSS SSTTIIIQKN EEGGGG---- -----TSVVV VEVIVVVVPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPRRIHKNII IQQDDVVVSF FFSSGGGRDP DDAAYY---- -----AVLLL LKKLLLLLYY --RRLHPDAA AQQGVGGCSS SSTTVVVFKE KKDDGG---- -----KAAAA AEVIVVVVPS --RRLHPDAA AQQGVGGCSS SSSSIIIFKE KKDDGG---- -----KAAAA AEVIVVVVPS --RRLHPAKK KTTGVGGSSS SSNNMMMIKT QQDDGG---- -----SSHHH HEAIVVVVKP --RRLHPAKK KTTGVGGSTS SSNNMMMIKT QQDDGG---- -----SNHHH HEVIVVVVEP --RRLHPSKK KTTGVGGSSS SSNNMMMIKN SSDDDD---- -----TSYYY YEVIVVVVKP --RRLHPSKK KTTGVGGSSS SSNNMMMIKN SSDDEE---- -----TSHHH HEVIVVVVKP --RRLHPSKK KTTGVGGCTS SSNNMMMVKT AADDGG---- -----SSHHH HEAIIIIIKP --RRLHPTSS SHHAVGGCGS SSGGIIIFPV EEEENN---- ---T-TAAAA ATVAIIIIPS --RRLHPTSS SHHAVGGCGS SSAAIIIFPD EEKKNN---- ---K-VTAAA ASVAIIIIPS ---------- ---------- ---------- ---------- ---------- ---------- --RRLHPREE EQQGVGGCXX XXXXXXXX-- ---------- ---------- ---------- --RRLHPKKK KEEGVGGCNA AAKKVVVFKK SSDDSS---- ---EFEKKKK KVDIGGGGKL ---------- ---------- ---------- ---------- ---------- ---------- --RRPWSNAA AYYASTTTTS SSQQLLLWED DDAAGG---- ---------- ----WWWWQA --RRAWEAHH HYYCTSSTTS SSQQLLLWED GGEEGG---- ---------- ----WWWWQA LELKPFFAPP LVTDIIDISD DDLLLYYLSS WGEQQQDDDS NNPPPVVTKK LGIFFFHHRR LPLKDFFMPP LVTDIIDISD DDLLLYYVSS WGEQQQDDDT NNPPPRRARR IGLYYYHHRR LPLQGFFAPP LVTDIIDLSD DDLLLYYVSS WGEQQQDDDS DDPPPVVASS IGIAAARRRR LPLQGFFAPP LVTDIIDLSD DDLLLYYVSS WGEQQQDDDS DDPPPKKASS IGIAAARRRR LDLKGFFAPP LVTDIIDLSD DDLLLYYVAA WGEQQQDDDS DDPPPVVTKK IGIVVVKKKK LPLKGFFAPP LVTDIIDLSD DDLLLYYVSS WGDQQQDDDS DDPPPKKTKK IGIVVVSSRR LPLKPFFAPP LVTDIINLSD DDLLLYYVSS WGEQQQDDDS DDPPPRRTKK IGIVVVRRRR LPLKDFFAPP LVTDIINLSD DDLLLYYVSS WGEQQQDDDS DDPPPRRTSS LGIVVVRRKK KVGWMLLEPG LITDIILLSD DDLLLYYFSS WLDQQQDDDS NNPPPRRTQQ LGSIIIVVRR KVGWMLLEPG LITDIILLSD DDLLLYYFSS WLDQQQDDDS NNPPPRRTQQ LGSIIIVVKK KVGWMLLEPG LITDIILLSD DDLLLYYFSS WLDQQQDDDS DDPPPRRTQQ LGSIIIVVKK KVGWMLLEPG LITDIILLSD DDLLLYYFSS WLDQQQDDDS DDPPPRRTQQ LGSIIIVVKK KVGWLLLEPG LITDIILLSD DDLLLYYFSS WLDQQQDDDS DDPPPRRTQQ LGSIIIVVKK KVGWLLLEPG LITDIILLSD DDLLLYYFSS WLDQQQDDDS DDPPPRR--- ---------- KVGWLLLEPG LIT------- ---------- ---------- ---------- ---------- KVGWLLLEPG LITDIILLSD DDLLLYYFSS WLDQQQDDDS DDPPPRRTQQ LGSIIIVVKK KVGWMLLEPG LITDIILLSD DDLLLYYFNN WLDQQQDDDS DDPPPRRVQQ LGSIIIVVKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AVKFGVVSSN EFPPAAWIFS SDIIIIIFLL ---------- ---------- ---------- KVGWALLEPG LITDIILISD DDLLLYYFSS WLDQQQDDDT DDPPPKKVQQ LGSIIILLRR KVGWPMMEPG LITDIILISD DDLLLYYFSS WLDQQQDDDT DDTTPKKVQQ LGSIIIQQRR LVNWILLEPG LITDFFLISD DDLLLYYFVV WLDQQQNNNE DDLLPVVTQQ VGLIIIQQKK LVNWFLLEPG LITDFFLISD DDLLLYYFVV WLDQQQNNNE DDVVPKKTQQ AGLIIIQQKK LVNWILLEPG LITDFFLISD DDLLLYYFVV WLDQQQNNNE DDPPPVVTQQ VGLLLLQQKK LVNWILLEPG LITDFFLISD DDIIIYYFVV WLDQQQNNNE DDPPPVVTQQ VGLLLLQQKK LVNWILLEPG LITDFFVISD DDLLLYYLVV WLDQQQNNNE DDPPPVVAQQ AGLLLLQQKK KVGWALLEPA LITDIILISD DDLLLYYVSS WLDQQQDDDS DDPPVKKNQQ IGSVVVHHTT KVNWALLDPA LITDIILISD DDLLLYYVSS WLDQQQDDDS DDPPPKKNQQ IGSIIIHHSS ---------- ---------- ---------- ---------- ---------- ---------- -GNGEIIMGG MMTDIILISD DDLLLYYFSS WRDQQQDDDS DDRRPRRTQQ LGAIIIQQRR VTSGVAADGG MISDIIIISD DDLLLYYVNN WRDQQQDDDT DDPPPKKTQQ LGAIIICCSS ---------- ---------- ---------- ---------- ---------- ---------- KVDIGNNAIP LPVDIISIAD DDLLLWWINN FMKLLLDDDS DDPPPFFIEE IRQVVVNN-- KVDIGEEAVP LPVDIISISD DDLLLWWVNN FMKLLLDDDS DDPPPRRVEE IAQVVVNN-- ADDH------ ---------- ---AGKAPPQ MMLISSRDGR RVYYVSSDNN NQQFGLLLGM EPPH------ ---------- ---SGEAPPQ MMIVSSRDGR RVYYISSNNN NQQFGLLLGM APPH------ ---------- ---NGTGPPQ MMVISSRDGR RVYYWSSDDD DQQFGVVVAQ TPPH------ ---------- ---NGAGPPQ MMVISSRDGR RVYYWSSDDD DQQFGVVVGE TPPH------ ---------- ---NGTGPPQ MMVISSRDGK RVYYWSSDEE EQQFDRRRAM ATTHG----- ---------- --AKNAGPPQ MMVISSRDGR RVYYFSSDPP PQQFGIIIGM AGGH------ ---------- --ATSEGPPQ MMVISSRDGR RVYYFSSDEE EQQFGIIIGM AAAH------ ---------- ---ASPGPPQ MMVVSSRDGR RVYYFSSDEE EQQFGIIIGI GGGSQLE--D DQQETCCQPP VVVKGRGPPQ MMILSSLDGK RLYYASSDKK KQQFDLLLRG GGGSQLE--D DQQETCCQPP VVVKGRGPPQ MMILSSLDGK RLYYVSSDKK KQQFNLLLRG GGGPQLE--D DQQEKSSQPP VVVKGKGPPQ MMILSSLDGK RLYYVSSDKK KQQFDLLLRG DGGPQLD--D DQQEDSSQPP VVVKGQGPPQ MMILSSLDGK RLYYVSSDKK KQQFDLLLRG GGGPQLE--D DQQEKSSQPP VVVKGRGPPQ MMILSSLDGK RLYYISSDKK KQQFDLLLRG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGPQLE--D DEEEKSSQPP VVVKGRGPPQ MMILSSLDGK RLYYISSDKK KQQFDLLLRG GGGPQLE--D DQQEKSSQPP VVVKGRGPPQ MMILSSLDGK RIYYVSSDKK KQQFDLLLRG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGPTLE--D DKKDECCQPP IIVKGKGPPQ MMILSSLDGK RLYYVSSDKK KQQFDMMMKG GGGPTLE--D DKKEECCQPP TTVKGIGPPQ MMILSSLDGK RIYYVSSDKK KQQFDLLLKG GSSPAIG--E EDDGTWWQSS EEIQGKGPPQ MMILTTLDGK RLYYVSSDKK KQQFGLLLEG GSSPVVK--D DDDGTWWQSS EEIQGKGPPQ MMILSSLDGK RLYYVSSDKK KQQFKLLLEG GSSPKVG--E EDDGSFFQFF QQIKGSGPPQ MMILSSLDGK RLYYASSDRR RQQFELLLDG GSSPKVG--E EDDGTFFQFF QQIKGSGPPQ MMILSSLDGK RLYYASSVVV VSSFEIIIEG GSSEVVT--E EDDDEEEQYY QQVKGRGPPQ MMILSSLDGK RIYYVSSDEE EQQFDLLLKG ESSNKLE--G GEEK---PII YYVKGKGPPQ MMLLSSLDGK RLYYVSSDDD DQQFEHHHKG ETTTKLE--E EDDH---EII YYVKGQGPPQ MMLLSSLDGK RLYYVSSDDD DQQFENNNRG ---------- ---------- ------GPPA KKILSSVDGK RLYYVSSDKK KQQFNVVVKG DAAPRLN--D DPPEKEEAPP FFLKGRGPPQ MMLLSSLDGR RLYYVSSDKK KQQFEMMMAG DLLPVVKEED DKKEKEERPP YYVKGRGPPQ MMLLSSLDGK RLYYVSSDKK KQQFKMMMSG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMVQSSWDGK RVYYFSSD-- --------KG ---------- ---------- ---------- MMVSSSWDGQ RLYYYSSD-- --------KG VVKKLNNAAA NN----PSGL LIDKEEFFVD FFGG-----R HVRRLSSGDD ASSSSCYYY- AAKKVNNVVV NN----PEGL LLEKEEFFVD FFGG-----R HVRRLWWGDD ASSTTCYYY- VVLLAHHAAA GG----PDGL LLADDDYWVE FFPP-----R HIRRLEEGDD CSSTTCYYYV VVMMANNVVV GG----GNGL LLDKDDYFVS FFPP-----R HIRRLEEGDD CSSTTCYYYV VVMMANNVVV GG----ENGL LLDKDDFWVD FFPP-----R HIRRLEEGDD CSSTTCYYYV VVKKLDDAAA GG----PNGI IFDPKKFFLE WWPP-----R HVRRLQQGDD CSSSSCYYY- VVKKVDDVVV NN----PDGM MFDPNNFFVD FFGG-----R HIRRLQQGDD ASSSSCFFF- AAKKAEEAAA DD----PGGL LLDPGGFFTE VVGG-----R HIRRLEEGDD SSSSSCYYY- SSVVMLLQQQ VVDDDDVNGL LLNPNNFLVD FFGGPLLLPL HLRRYPPGDD CSSSSI---- SSVVMLLQQQ IIDDDDANGL LLNPNNFLVD FFGGPLLLPL HLRRYPPGDD CSSSSI---- SSVVMLLQQQ IIDDDDVKGL LLNPNNFLVD FFGGPLLLPL HLRRYPPGDD CSSSSL---- SSVVMLLQQQ IIDDDDVKGL LLNPNNFLVD FFGGPLLLPL HLRRYPPGDD CSSSSL---- SSVVMLLQQQ VVDDDDVKGL LLNPNNFLVD FFGGPLLLPL HLRRYPPGDD CSSSSI---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSVVMLLQQQ VVDDDDVKGL LLNPNNFLVD FFGGPLLLPL HLRRYPPGDD CSSSSI---- SSVVMLLQQQ IIDDDDVKGL LLNPNNFLVD FFGGPLLLPL HIRRYPPGDD CTTSSL---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSVVMLLQQQ IIDDDDEKGL LLNPNNFLVD FFGGPGGGPL HLRRYPPGDD CSSSSV---- AAVVMLLQQQ IIDDDDKKGL LLNPNNFLVD FFGGPDDDPL HIRRYPPGDD CTTSSI---- SSHHILLQQQ IIDDDDEKGL LINPNNFFVD FFGGPDDDPL HMRRYPPGDD CTTSSI---- SSHHILLQQQ IIDDDDENGL LINPNNFFVD FFGGPDDDPL HMRRYPPGDD CTTSSI---- SSHHIIIQQQ IIDDDDEKGL LINPNNFFVD FFGGPEEEPL HMRRYPPGDD CTTSSI---- SSHHIIIQQQ IIDDDDEKGL LINPDDFFVD FFGGPDDDPL HMRRYPPGDD CTTSSI---- SSHHMLLQQQ IIDDDDEKGL LINPNNFFVD FFGGPEEEPL HMRRYPPGDD CTTSSI---- AATTMVVQQQ VVNNNNESGM MINRDDFLID FFGGEGGGPL HMRRYPPGDD CTTSSI---- AATTMLLQQQ IIDDDDITGM MINKNNFLID FFGGPGGGPL HMRRYPPGDD CTTSSI---- SSVVMLLQQQ IIDDDDEKGL LVNKNNFLVD FFGGPNNNPL HIRRFPPGDD STTSSA---- GGTTIVVQQQ LLDDDDENGM MLNENNFLVD FFGGPYYYPL HMRR------ ---------- GGHHIVVLLL IIDDDDVNGI ILNEDDFLVD FFAAPYYYPL HMRRYPPGDD CTTSSLAAAA ---------- ---------- ---------- ---------- ---------- ---------- KKDDDAAQQQ YYLLLLNWDK KLVEDDFAVD FFYYGLLL-R HMRRFGGSAA LYYSS----- KKDDDEEQQQ FFLLLLYWDK KLKEQQFAID FFYYKLLL-R HMRRFGGRAA LYYAAGDDDR ------- ------- KRR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LVVQQAE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NNNSSAKKKA KKKPSEEEAT PRTTPPGLLL TAAADDDGAA MLRRQQLLTP PGGSPVRRKK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YQEEATFSSA AIQVLLLASS SSSSGRSSVP GLLLLLESSS SAAAKQQPPQ AAAAAAVQWA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------LL ---------- ---------- ---------- ---------- ---------- ---------- MAGGSPTLPP PLNNRRRTTT TPPPAPPPHP RVVVVVLRRL LVVPYRRNNP PPPPRRLPCP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----VKRRRD PPPPTTFYYY PSKMAMKPPP ---------- ---------- ---------- ----AKPPPD PPPPTTFYYY PTRDAMRPPP ---------- ---------- ---------- ----MRPPPD PPPPTTFHHH ASELAMQPAA ---------- ---------- ---------- ----MRPPPD PPPPTTFHHH ASKLAMEPAA ---------- ---------- ---------- ----MRPPPD PPPPTTFYYY PSKLAMEPVV ---------- ---------- ---------- ----AKPPPD PPPPSSFYYY PSRLAAKPPP ---------- ---------- ---------- ----VRPPPD PPPPTTFYYY PSRMAVKPAA ---------- ---------- ---------- ----ARPPPD PPPPTTFYYY PSKMAMQPRR ---------- ---------- ---------- --MAT-CCCG PPPPGGYPPP TPEAMK-PRR ---------- ---------- ---------- ---------- ---------- -----M-PRR AHLLPPPPPG GKKGGGAAVV VLLAAAGLLG GAHSG-CCCG PPPPGGYPPP SPEAMK-PRR ---------- ---------- ---------- ---------- ---------- ----MK-PRR ---------- ---------- ---------- --MAG-CCCG PPPPGGYSSS TPEAMK-PRR ----AAEEER RAAGGGAFTT TLLSSAPMRI ISTAG-CCCG PPPPGGYSSS TPEAMK-PRR ---------- ---------- ---------- --MAG-CCCG PPPPGGYSSS TPEAMK---- ---------- ---------- ---------- --MAG-CCCG PPPPGGYSSS TPEAMK-PRR -MLLGGKKKE EEEGGGHTAA AQQWWLGQLQ QDTAG-CCCG PPPPGGYPPP TPEAMK-PRR LKSSQQGGGC CLLFFFDQTT TNNEEHYCTV VTSPG-CCCG PPPPGGYSSS TPEAMK-PRR ---------- ---------- ---------- --MAG-CCCG PPPPGGYSSS TPEAMK-PRR PPAARRHHHS SLLLLLQHII IMMGGAVETA AANGCAKKKG PPPPGGYAAA TPEAMEKPRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MG-CCCG PPPPGGYKKK SPDAMK-PRR ---------- ---------- -MMTTLHGVN NKKSGKSSSG PPPPGGYAAA SPESMS-PRR ---------- ---------- -MMTTLHAVS SKVNGKSSSG PPPPGGYAAA SPEAMS-PRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MVGGGG PPPPGGYAAA TPAAMS-PSS ---------- ---------- --------MA AANGCATTTG PPPPGGYAAA TPEAMEKPRR ---------- ---------- ---------S SNCGH----G PPPPGGYAAA SPDAIK-PRR ---------- ---------- ---------P P-CPH----G PPPPGGYAAA SPDAIK-PRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----SKCCCG PPPPGGYAAA TPDAVRNPVV ---------- ---------- ---------- ---------- ---------- ----MRSPRR ---------- ---------- ---------- ---------M PPPPGGLIII T-DILISDDD --MMKKRRRR REEGGG---- ------ALAG GALAPAFFFA DDDDEETCCC QSYMPKIGQQ --MMKKRRRF FIISSSGPSS SMMFFLALVG GALAPVRRRA DDDDEETCCC ASYMKKIGQQ EDAVAAACCL LTTTINNRRD IVVKKKSTYY SKIVHHKVEE EELYYYIHHH HWWNAAACSS EDAVAAAAAL LVTTVNNAAD LVVKKKSTYY GKVIYYKLDD DDLYYYIHHH HWWNAAACSS EEATLLLLLL LPFF---RRD LVIGGGSTYY GKIVHHTVTT TTMNNNTHHH HWWNAAACSS ENATLLLLLL LPFF---KKD LVIGGGSTYY GQIVHHTVTT TTMNNNKHHH HWWNAAACSS EKATLLLMML LPAA---KKD LVVTTTSKFF GQIVHHQLII IIMNNNKHHH HWWNAAACSS ETAVAAAMMF FPRR---QQD IVVAAASRYY ASIVGGQVAA AAMHHHAHHH HWWNAAACSS EKAVVVVRRL LPAAG--KKD MVVQQQSTFF GQVVGGVTDD DDMYYYTHHH HWWNAAACSS ERGVAAALLL LPRR---RRD LVLDDDSTYY AQIVGGRVEE EEMNNNAHHH HWWNAAACSA EEVLPPPCCI IRTTTEEAAD LTVKKKSQYY SQVIHHRLPP PPMYYYLHHH HWWNTTTCSS EEVLPPPCCI IRTTIEEAAD LTVKKKSHYY SQVIHHRLPP PPMHHHLHHH HWWNTTTCSS EEVLPPPCCI IGTTIEEAAD LTVKKKSQYY CQVIHHRLPP PPMNNNLHHH HWWNAAACSS EEILPPPCCI IRTTIEEAAD LTVKKKSQYY CQVIHHRLPP PPMHHHLHHH HWWNTTTCSS EEVLPPPCCI IRTTTEEAAD LTVKKKSQYY CQVIHHRLPP PPMNNNLHHH HWWNTTTCSS EEVLPPPCCI IRTTTEEAAD LTVKKKSQYY CQVIEE---- ---------- ---------- ---------- ----TEEAAD LTVKKKSQYY CQVIHHRLPP PPMNNNLHHH HWWNTTTCSS EEVLPPPCCI IRTTTEEAAD LTVKKKSQYY CQVIHHRLPP PPMNNNLHHH HWWNTTTCSS EEVLPPPCCI IRTTTEEAAD LTVKKKSQYY SQVIHHRLPP PPMYYYLHHH HWWNTTTCSS EEVLPPPCCI IRTTTEEAAD LTVKKKSQYY CQVIHHRLPP PPMNNNLHHH HWWNTTTCSS EEVLPPPCCI IRTTTEEAAD LTVKKKSQYY CQVIHHRLPP PPMNNNLHHH HWWNTTTCSS EKVVTTTCCV VNTTINNKKD LTVSSSSTYY SQVIHHRLPP PPVHHHIHHH HWWNSSSCSS ---------- ---------- ---------- ---------- --MNNNTHHH HWWNTTTCSS EEVLPPPCCI IRTTINNKKD LTVKKKSSYY SQVIHHRLPP PPMNNNVHHH HWWNTTTCSS ESIVTTTAAV VATTIEEKKD LTVSSSSTYY SKVIHHRLPP PPVYYYVHHH HWWNSSSCSS ETIVTTTAAV VATTIEEKKD LTVNNNSTYY SKVIHHRLPP PPVYYYVHHH HWWNSSSCSS ---------- ---------- ---------- ---------- --MFFFVHHH HWWNSSSCSS EKIVTTTAAV VTTTIDDKKD LTVSSSSSYY SSVIHHRLPP PPMFFFVHHH HWWNSSSCSS EKLVTTTCCV VNTTINNKKD LTVNNNSTYY SQVIHHRLPP PPVHHHVHHH HWWNAAACSS EELVTTTAAP P-NNADDGGD ITVEEESTFF CQVISSRVDD DDVHHHIHHH HWWNAAACSS EELVTTTAAP P-HHRDDGGD ITVEEESTFF CQIISSRVDD DDVNNNIHHH HWWNAAACSS ---------- ---------- ---------- ---------- ---------- ---------- EKLVVVVCCV VPLLEEEHHD LTVAAASTYY CQVIHHRTYY YYTSSSKHHH HWWNTTTCSS EKLTVVVTTV VPLLEPPHHD LTVEEESTYY CQIVHHRTFF FFTRRRKHHH HWWNAAACSS RFYSNNNWWL LGIIQYYDDT RNPQQQVLGG GSVLKKDGPP PPVVVVLDDD DPPTPPPRIL EEVVWWWTTL LVGGGDDEED LTIGGGSTRR GQVINNSVSS SSVGGG-HHH HFFSAAA--- EDVVWWWTTL LAGGGDDEED LTVKKKSQYY GKVVNNTLSS SSVGGG-HHH HFFTDDD--- SCC-NNG--K PPPRVRRRIY YIDTKPPPPP PRPKIIKKKI IEEPPVVVVG YYLLTHHGDI SCC-NNA--K PPPRVRRRIY YIDTKPPPPK KRPAVAKKKV VEEPPAAARG YYYYTHHGDI SSS-LLTGGH AAARIRRRIY YVDTKPPPPP PTARIHKKKI IEEPPIIIKG YYPPTHHGEI SSS-LLAGGH AAARIRRRIY YIDTKPPPPP PTAKIHKKKI IEEPPVVVKG YYPPTHHGDI SSS-LLTGGH AAARIRRRIY YIDVK----P PLAKIHKKKI IEEPPVVVKG YYPPTHHGEI SCC-NNAPPH PPPRVRRRIY YIDTKPPPPP PLPFLAKKKI IEEPPLLLRG YYPPTHHGGI SCC-NNAPPH PPPRVRRHIT TIDTKPPPPP PTPKVVKKKI IDDPPLLLRG YYPPTHHGDI ACC-YYAPPH PPPRVRRRIH HIDTKPPPPP PRPRIVKKKI IEEPPLLLRG YYPPTHHGDV S-----FGGD SSSRLMMRIY YVDVGSSSSP PRPKLHKKKI IEEAAIIIKN VVTTTHHLSE S-----FGGD SSSRLIIRIY YVDVGSSSSP PRPKLHKKKI IEEPPIIIKN LLLLTHHLSE S-----FGGD SSSRLMMRIY YVDVGSSSSP PRPKLHKKKI IEEAAIIIKG LLVVTHHLSE S-----YGGD IIIRLIIRIY YVDVGTTTTP PRPKLHKKKI IEEPPIIIKN LLFFTHHLSE S-----FGGD SSSRLIIRIY YVDVGSSSSP PRPKLHKKKI IEEPPIIIKE LLLLTHHLSE ---------- ---------- ---------- ---------- ---PPIIIKE LLLLTHHLSE S-----FGGD SSSRLIIRIY YVDVGSSSSP PRPKLHKKKI IEEPPIIIKE LLLLTHHLSE S-----FGGD SSSRLIIRIY YVDVGSSSSP PRPKLHKKKI IEEPPIIIKE LLLLTHHLSE S-----FGGD SSSRLIIRIY YVDVGTTTTP PRPKLHKKKI IEEAAIIIKG LLPPTHHLTE S-----FGGD SSSRL----- ---------- ---------- ---------- ---------- S-----FGGD SSSRLIIRIY YVDVGSSSSP PRPKLHKKKI IEEPPIIIKE LLLLTHHLSE S-----HGGD PPPRLLLRVY YVDTATTTTP PRPSLHKKKV VEESSIIING LLPPTHHLSD S-----YGGD AAARLIIRIY YVDVGTTTTP PRPRIHKKKV VEEPPVVVKG LLLLTHHLCE S-----YGGD SSSRLIIRIY YVDVGSSSSP PRPRIHKKKV VEEPPVVVKG LLPPTHHLCE S-----HGGD PPPRAVVRIY YVDTKTTTTP PRPSLHKKKV VDDPPIIIKG LLPPTHHLSE S-----HGGD PPPRVVVRVY YVDTKTTTTP PRPSLHKKKV VEEPPIIIKG LLPPTHHLSE S-----HGGD AAARLIIRIY YADTKEEEEP PRPSLYKKKV VDDPPIIIKG LLPPTHHLSE S-----HGGD AAARLIIRIY YADTKEEEEP PRPSLYKKKV VDDPPIIIKG LLPPTHHR-E S-----HGGD PPPRLLLRVY YVDTLKKKKP PRPALHKKKV VEEAAIIIKG LLPPTHHLSE S-----HDDK PPPRVNNRIY YINVENNNN- -RIYLEHHHI IEEPPLLLL- LLPPTHHLDN S-----HDDK PPPRVNNRIY YVNVENNNN- -RIYLQHHHI IEEPPLLLL- LLPPTHHLDN ---------- ----PSSVEG GKFVGGGGG- ---------- ---------- ---------- SFFV--GGGK EEERLNNRIF FVDTGTTTTP PRPKLAKKKI IEEGGVVVGD CCPPTHHLNN SYYVEESSSK TTTRLNNFIY YIDVVTTTTP PRPEIVKKKI IDDGGVVVSN VVPPTHHLNN L------GGK RRRGQDDRLY YVTSLYYYYA AWKQFYPPP- -----LLLFV LLSSTDDQNA ---------- ---RTDDRIF FIDVHSSSSP PSPKLHKKKI IDDTTVVVSG VVPPTFFLGM ---------- ---RADDKIF FVDVHSSSSP PAPVLSKKKI ITTDDVVVSG VVPPTYYLGM IYYYIIAALL NNE---GGGG GGLHHEEDRQ ---------- ----LAYFFF WW-PPVEWAA IYYYIIAALL GGP---GGGG GGFHHEEYRQ ---------- ----FAYFFF WW-PPVEWTT IYYYVVTTLL GGAGGKGGPP GGFCCEEDRQ ---------- ----KHYFFF WW-PPYEWAA IYYYVVTTLL GGGGGKGGPP GGFCCEEDRQ ---------- ----LHYFFF WW-PPYEWAA IYYYVVTTLL GGGGGEGGPP GGFCCEEDRQ ---------- ----KHYFFF WW-PPYEWGG IYYYVVAALL NNA---GGGG GGAAAEEERQ ---------- ----FAYGGG WW-GGTEWGG IYYYIIAALL SSP---GGGG GGFHHEEDRQ ---------- ----LHYFFF WW-GGTEWGG VYYYVVAALL SSP---GGGG GGFHHEEERQ ---------- ----LAYFFF WW-GGTEWGG EVVVMMNNTT GGD---QGGG SSVGGEEPGS ---------- ----MGYFFF YY-RRVEWAA EVVVMMSSSS GGD---QGGG GGVGGEEPGA ---------- ----MGYFFF YY-RRIEWAA EVVVMMSSTT GGD---KGGG GGVGGEEPGA ---------- ----MGYFFF YY-RRVEWAA EVVVMMSSTT GGD---EGGG GGVGGEEPGA ---------- ----LGYFFF YY-RRVEWAA EVVVMMSSSS GGD---KGGG GGVGGEEPGA ---------- ----SGYFFF YY-RRVEWAA EVVVMMSSSS GGD---KGGG GGVGGEEPGA ---------- ----LGYFFF YY-RRVEWAA EVVVMMSSSS GGD---KGGG GGVGGEEPGA ---------- ----LGYFFF YY-RRVEWAA EVVVMMSSSS GGD---KGGG GGVGGEEPGA ---------- ----LGYFFF YY-RRVEWAA EVVVMMSSTT GGD---KGGG GGVGGEEPGA ---------- ----MGYFFF YY-RRVEWAA ---------- ---------- ---------- ---------- ---------- ---------- EVVVMMSSSS GGD---KGDD GGLPP----- ---------- ---------- ------ISAA DIIIMMSSCC GGD---EAGG NNFDDSSRLI ---------- ----KERHHH YYYAALIQCC EIIIMMSSSS GGD---YGGG GGVGGEEEGA ---------- ----FGYFFF YY-RRVEWGG EIIIMMSSSS GGD---CGGG GGVGGEEEGA ---------- ----FGYFFF YY-RRVEWGG ELLLMMSSCC GGD---DAGG NNFDDEEPGP ---------- ----FGYFFF YY-RRTSWGG EIIIMMSSCC GGD---DAGG NNFDDEEPGP ---------- ----FGYFFF YY-RRTSWGG EIIILLSSCC GGD---EAGG NNFDDEEPGP ---------- ----FGYFFF YY-RRTSWGG EIIILLSSCC GGD---EAGG NNLDDEEPDP ---------- ----YGYFFF YY-RRTSWGG EIIIMMSSCC GGD---EAGG NNFDDEEPGP ---------- ----FGYYYY YY-RRTSWGG NIIIMMSSTT GGE---NPGG NNLGGPPDEV ---------- ----FNYFFF YY-RRVEWGG NIIIMMSSTT GGE---DPGG NNLGGPPDGV ---------- ----FNYFFF YY-RRIEWGG ---------- ---------- ---------- ---------- ---------- ------LRGG NIIIMMSSII GGD---EAGG --FDDSSGDA ---------- ----CGYYYY YY-HHVEWGG NIIIMMSSVV GGD---EAGG --FDDTTGDA ---------- ----CGYFFF YY-YYVEWGG ALLLKKDDGG NNE---LPLL NNIKKEESQE ---------- ----LQLNNN NN---KRPDD MMMMIIGGLL NND---DGTT AAVDDMMTAM AAVGDDVVVV AAAAYGYIII AA-RRVSFTT MLLLIIGGLL NNN---DGTT AAVNNIITDL KKTG--YYYY AAAAYDYVVV AA-RRLSFTT APN--IIEDL KLLELKKK-- NIHFFWKRRI IIHSTTLLGE R-----HPPP PTGIINVVVS TPR--FFEEF SLLELKKKGG NLHVVWKRRL LLYADDLLGE R-----HPPP PTGVVNVVLN APP--FFENI VPPELLLLNN HLHFFWARRV VVQTDDLLGQ Q-----HPPP PVGVVGVVVD APP--FFENI VPPELLLLNN HLHFFWARRV VVQTDDLLGN Q-----HPPP PVGVVGVVVD GPP--FFENI VPPELLLLNN HIHFFWDRRV VVQTDDLLGN Q-----HPPP PSGCCGVVVD GPD--VVEDL VPPDLLLLAA RLHFFWRRRL LLQEDDFFGE Q-----HPPP PTGVVNVVIS GPR--VVESV LGGDLLLLGG HLHVVWRRRL LLQTDDLLGE Q-----HPPP PTGMMNVVVS GPN--IIEGL DPPQLLLLKK RLHIIWRRRL LLQADDVVGE Q-----HPPP PAGVVGVVVS APN--FFKDN PAAHEAAAGG SIFVVWRHHI IIQTQQMMT- G-----HPPP PSGVVGAALS APN--FFKDN PAAHEAAAGG SIHVVWRHHI IIQTQQMMK- G-----HPPP PDGVVGAALS APN--FFRDN PAADEAAAGG SLHVVWRHHI IIQTTTLLQ- G-----HPPP PDGVVGAALS APN--LLRDN PAADKAAAGG SLYVVWRRRV VVQTPPLLQ- G-----HPPP PDGVVGAALS APN--LLRDN PAADEAAAGG SLYVVWHHHV VVQTSSLLK- G-----HPPP PDGVVGAALS APN--LLRDN PAADEAAAGG SLYVVWRHHV VVQTSSLLK- G-----HPPP PDGVVGAALS APN--LLRDN PAADEAAAGG SLYVVWRHHV VVQTSSLLK- G-----HPPP PDGVVGAALS APN--LLRDN PAADEAAAGG SLYVVWRHHV VVQTSSLLK- G-----HPPP PDGVVGAALS APN--VVQNN PAADEAAAGG KLHVVWRHHV VVQTLLMMP- G-----HPPP PAGVVGAALS ---------- ---------- ---------- ---------- ---------- ---------- ASN--RRLTR DYYPSAAASS GT-------- ---------- ---------- ---------- CSL--YYTTE LMMCTAAASS VSCLLDMRRD DDESPPLLQ- QNNPIIHKKK KNDDDVEEVS GPK--FFALK MEEEQAAAGG HLNVVWEHHI IIQTDDLLG- G-----HPPP PDGVVGAALS GPK--FFALK MEEDQAAAGG HLNVVWEHHV VVQTDDLLG- G-----HPPP PDGVVGAALS GPT--FFTKD LQQHADDDGG RLTCCIRGGR RRQTDDLLG- G-----HPPP PAGVVGAALS GPK--FFLQN LQQHADDDGG RLHVVYGGGK KKQTDDLLG- G-----HPPP PAGVVGAALT GPK--FFSKD LQQHADDDGG SLHVVYGGGK KKQLDDLLG- G-----HPPP PSGVVGAALS GPK--FFSKN LQQHADDDGG SLHVVYGGGK KKQLDDLLG- G-----HPPP PSGVVGAALS GPA--FFRTD LQQHQDDDGG RLHVVYGGGK KKQTDDLLG- G-----HPPP PSGVVGAALT GPN--IIKKN PAAHGEEEGG NVHIIFSKKL LLQTDDLLPP G-----HPPP PTAVVGAALG GPN--IIKKN PAAHPEEEGG NVHIIFTKKL LLQTDDLLPP G-----HPPP PTAVVGAALG GPV--VVCRE LKKCPEEEPP KKRVVY---- ---------- ---------- ---------- GPK--FFRRH PTTDDDDDTT CLNFFYERRF FFQTDDLLG- G-----HPPP PRGVVGAAFX GPN--WWRRK NVVDEDDDSS CLNFFYTQQY YYQTDDLLG- G-----HPPP PKGVVGAALN DPI--AAFEE SFFLKTTTPP QVAEEV---- ---------- ---------- ---------- TWSNYMMDFM LQQDEAAAKK NIVQQWTRRK KKKVNNVVPA ------WSSS SNASSTAALT TWNNYMMDFM LAADEAAAKK NVVTTWTKKK KKKVDDVVPA ------WEEE EACTTSAALT LKKKDLLLSS SFFFDDGKWA EEIEIIIPAA EPLEEGGPIP PPFAAVVPLL VTDDDDSSSL TKKKDLLLSS SFFFDDGKWA EEIDIIIEAA QPFEEGGPVD DDFMMVVPLL VTDDDDSSSL TTTTNLLLEE SWWWGGGKFV KKATIIIPAA EPATTAAPLG GGFAAVVPLL VTDDDDSSSL TTTTNLLLEE SWWWGGGKFA EEATIIIPPP EPAPPKKPLG GGFAAVVPLL VTDDDDSSSM TTTTNLLLQQ AWWWDDGTFA KKITIIIDPP VPADDAAPLG GGFAACCPLL VTDDDDSSSL LKKKDLLLSS SYYYKKDKWV RRIEIIIPAA EAADDPPPVG GGFAAVVPLL VTDDDDSSSM LKKKDLLLSS SYYYNNGSWL KKIDIIIPAA EPASSEEPIP PPFAAVVPLL VTDNNNSSSV LEEEDLLLSS SHHHNNGSWI RRIEIIIPAA EPAEEPPPLD DDFAAVVPLL VTDNNNSSSL SNNNIQQQRR YGGG------ --TWSSSVEE KVIQQVVKKM MMLEEMMPLL ITDLLLSSSL SNNNIQQQRR YGGG------ --TWSSSVEE KVIQQVVKKM MMLEEMMPLL ITDLLLSSSL STTTIQQQRR YGGG------ --TWSSSVEE KVIQQVVKKM MMLEEMMPLL ITDLLLSSSL STTTIQQQRR FGGG------ --TWSSSAQQ KVIQQVVKKM MMLEEMMPLL ITDLLLSSSL STTTIQQQRR YGGG------ --TWSSSVEE KVIQQVVKKL LLLEEMMPLL ITDLLLSSSL STTTIQQQRR YGGG------ --TWSSSVEE KVIQQVVKKL LLLEEMMPLL ITDLLLSSSL STTTIQQQRR YGGG------ --TWSSSVEE KVIQQVVKKL LLLEEMMPLL IT-------- STTTIQQQRR YGGG------ --TWSSSVEE KVIQQVVKKL LLLEEMMPLL ITDLLLSSSL STTTIQQQRR YGGG------ --TWSSSVEE KVIEEVVKKM MMLEEMMPLL ITDLLLSSSL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FSSSGRRRGG SYYY------ --AVVVVLKK RKLDDLLVAG GGVSSLLSEE FPPWWWFFFF STTTVFFFRR YGGG------ --KWAAAAEE KVIKKVVKEA AALEEMMPLL ITDLLLSSSL SSSSIFFFRR YGGG------ --KWAAAAEE KVIQQVVKEP PPMEEMMPLL ITDLLLSSSL SNNNMIIIRR FGGG------ --SWSSSHEE LAIPPVVKQI IILEEMMPLL ITDLLLSSSL SNNNMIIIRR FGGG------ --SWNNNHEE IVISSVVKQF FFLEEMMPLL ITDLLLSSSL SNNNMIIIRR FDDD------ --TWSSSYEE IVISSVVKEI IILEEMMPLL ITDLLLSSSL SNNNMIIIRR FEEE------ --TWSSSHEE VVISSVVKEI IILEEMMPLL ITDLLLSSSL SNNNMVVVRR FGGG------ --SWSSSHEE VAISSIIKRI IILEEMMPLL ITDVVVSSSL SGGGIFFFRR HNNN------ --THAAAATT LVAFFIIKSA AALEEMMPLL ITDLLLSSSM SAAAIFFFRR HNNN------ --VQTTTASS LVATTIIKEA AALDDMMPLL ITDLLLSSSM ---------- ---------- ---------- ---------- ---------- ---------- XXXXXXXXXX X--------- ---------- -------QEE EEIMMMMGMM MTDLLLSSSL AKKKVFFFHH KSSS------ --EAKKKKVV IDIPPGGDGV VVADDMMGMM ISDIIISSSL ---------- ---------- ---------- ---------- ---------- ---------- SQQQLWWWLL YGGG------ ---------- ---EEWWAAG GGNAADDILL PVDSSSAAAA SQQQLWWWLL YGGG------ ---------- ---EEWWAAG GGEAAKKVLL PVDSSSSSSN KKFLLLSWIG EYYISNNPPP FFPVVVLTGG KKKKLLGGIH HDHPP----- ---------- RRFLLVSWLG EYYITNNPPP HHPRRRLAGG RKKKIIGGLH HPHPP----- ---------- RRFLLVSWTG EYYVSDDPPP HHPVVVLAGG SRRRIIGGIR RPHPP----- ---------- RRFLLVSWTG EYYVSDDPPP RRPKKKLAGG SHHHIIGGIR RPHPP----- ---------- KKYLLVAWLG EYYVSDDPPP MMPVVVLTGG KEEEIIGGIK KPHPP----- ---------- RRFLLVSWTG DYYVSDDPPP FFPKKKLTGG KRRRIIGGIS STHPPG---- ---------- RRFLLVSWTG EYYVSDDPPP FFPRRRLTGG KQQQIIGGIR RGHPP----- ---------- RRFLLVSWTG EYYVSDDPPP FFPRRRHTGG SRRRLLGGIR RAHPP----- ---------- RRFLLFSWHG DYYISNNPPP QQPRRRLTGG QFFFLLGGSV VGSVVQVLLE DELLTCCQPP RRFLLFSWHG DYYISNNPPP KKPRRRLTGG QFFFLLGGSV VGSVVQVLLE DELLTCCQPP RRFLLFSWHG DYYISDDPPP QQPRRRLTGG QFFFLLGGSV VGPVVQVLLE DELLKSSQPP HHFLLFSWHG DYYVSDDPPP QQPRRRLTGG QFFFLLGGSV VGPVVQVLLD DELLDSSQPP RRFLLFSWHG DYYISDDPPP QQPRRRLTGG QFFFLLGGSV VGPVVQVLLE DELLKSSQPP RRFLLFSWHG DYYISDDPPP QQPRRRL--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRFLLFSWHG DYYISDDPPP QQPRRRLTGG QFFFLLGGSV VGPVVQVLLE DELLKSSQPP RRFLLFNWHG DYYISDDPPP KKPRRRLVGG QFFFLLGGSV VGPVVQVLLE DELLKSSQPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLLIIFL--- ---------- ---------- ---------- ---------- ---------- RRFLLFSWHG DYYITDDPPP RRPKKKLVGG QFFFLLGGSL LGPVVTVLLE DDLLECCQPP RRFLLFSWHG DYYITDDTTT RRPKKKLVGG QFFFLLGGSQ QGPVVTVLLE DELLECCQPP RRFLLFVWHG DYYIEDDLLL KKPVVVLTGG QWWWVVGGLQ QSPVVAAIIG EGKKTWWQSS RRFLLFVWHG DYYIEDDVVV KKPKKKLTGG QWWWAAGGLQ QSPVVVAVVK DGEETWWQSS RRFLLFVWHG DYYIEDDPPP KKPVVVLTGG QWWWVVGGLQ QSPVVKAVVG EGNNSFFQFF RRFIIFVWHG DYYIEDDPPP KKPVVVLTGG QWWWVVGGLQ QSPVVKAVVG EGNNTFFQFF RRYLLLVWHG DYYIEDDPPP AAPVVVLAGG QWWWAAGGLQ QSEVVVYVVT EDKKEEEQYY RRFLLVSWHG DYYISDDPPP LLVKKKLNSS QYYYIIGGSH HSNVVKVLLE GK-----PII RRFLLVSWHG DYYISDDPPP KKPKKKLNSS QFFFIIGGSH HTTVVKVLLE EHDD---EII ---------- ---------- ---------- ---------- ---------- ---------- RRYLLFSWHG DYYISDDRRR AAPRRRLTGG QFFFLLGGAQ QAPRRRVLLN DELLKEEAPP RRFLLVNWHG DYYITDDPPP EEPKKKLTGG QFFFLLGGAC CLPNNVIVVK DELLKEERPP ---------- ---------- ---------- ---------- ---------- ---------- QQTLLINFDG KFFISDDPPP HHPFFFQIYY EVVVIIDRQN N--------- ---------- SSRLLVNFDG KFFISDDPPP HHPRRRQVYY ETTTIIGAQN N--------- ---------- --AGHKGAEE IISRRGRRRV VVVVTTTNSS LSWDDNFFPP GLLLLKGGWM MVVVKNNNN- --SGAEGASS VVSRRGRRRV VIIITTTNSS LSWNNNFFPP GLLLLRGGWM MAAAKNNNN- --NGRTGGEE IISRRGRRRV VWWWTTTNSS LSWDDDFFPP GVVVVPAAAQ QVVVLHHHG- --NGKAAGEE IISRRGRRRV VWWWTTTNSS LSWDDDFFPP GVVVVPGGVE EVVVMNNNG- --NGKTYGEE IISRRGKKKV VWWWTTTNSS LSWDDEFFPP DRRRRGAAAM MVVVMNNNG- -AKNGAGGEE IISRRGRRRV VFFFTTTNSS LGVDDPFFPP GIIIIDGGWM MVVVKDDDG- -ATSAEGGEE IISRRGRRRV VFFFTTTNSS LRWDDEFFPP GIIIIKGGWM MVVVKDDDN- --ASGPGGEE VVSRRGRRRV VFFFSSSNSS LAWDDEFFPP GIIIIRGGWI IAAAKEEED- VVKGKRGGQQ LLSLLGKKKL LAAATTTTSS LSWDDKFF-- DLLLLIRREG GSSSVLLLVD VVKGKRGGQQ LLSLLGKKKL LVVVTTTTSS LSWDDKFF-- NLLLLIRREG GSSSVLLLID VVKGKKGGQQ LLSLLGKKKL LVVVTTTTSS LSWDDKFF-- DLLLLIRREG GSSSVLLLID VVKGKQGGQQ LLSLLGKKKL LVVVTTTTSS LSWDDKFF-- DLLLLIRREG GSSSVLLLID VVKGKRGGQQ LLSLLGKKKL LIIITTTTSS LSWDDKFF-- DLLLLIRREG GSSSVLLLVD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVKGKRGGQQ LLSLLGKKKL LIIITTTTSS LSWDDKFF-- DLLLLIRREG GSSSVLLLVD VVKGKRGGQQ LLSLLGKKKI IVVVTTTTSS LSWDDKFF-- DLLLLIRREG GSSSVLLLID ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IVKGKKGGQQ LLSLLGKKKL LVVVTTTNSS LSWDDKFF-- DMMMMIKKEG GSSSVLLLID TVKGKIGGQQ LLSLLGKKKI IVVVTTTSSS LSWDDKFF-- DLLLLLKKEG GAAAVLLLID EIQGQKGGQQ LLTLLGKKKL LVVVTTTNSS LSWDDKFF-- GLLLLVEEKG GSSSHLLLID EIQGKKGGQQ LLSLLGKKKL LVVVTTTNSS LSWDDKFF-- KLLLLVEEQG GSSSHLLLID QIKGKSGGQQ LLSLLGKKKL LAAATTTNSS LSWDDRFF-- ELLLLMDDKG GSSSHIIIID QIKGKSGGQQ LLSLLGKKKL LAAATTTNSS LSWVVVFF-- EIIIIMEEKG GSSSHIIIID QVKGHRGGQQ LLSLLGKKKI IVVVTTTNSS LSWDDEFFGG DLLLLVKKKG GSSSHLLLID YVKGRKGGQQ LLSLLGKKKL LVVVTTTTSS LKWDDDFF-- EHHHHVKKSG GAAATVVVVN YVKGRQGGQQ LLSLLGKKKL LVVVSSSTSS LKWDDDFF-- ENNNNVRRSG GAAATLLLID ------GGQQ LLSVVGKKKL LVVVTTTNSS FSWDDKFF-- NVVVVVKKEG GSSSVLLLID FLKGRRGGQQ LLSLLGRRRL LVVVSSSSSS LSWDDKFF-- EMMMMVAAAG GGGGTVVVLD YVKGRRGGQQ LLSLLGKKKL LVVVSSSSSS LSWDDKFF-- KMMMMVSSQG GGGGHVVVID ---------- ---------- ---------- ---------- ---------- ---------- --------SS QQSWWGKKKV VFFFSSSSSS LAWDD----- ------KKKG GKKKDAAAYL --------SS SSSWWGQQQL LYYYTTTSSS LAWDD----- ------KKKG GKKKDEEEFL -----PGGGG GLEIKKKKFF VFG------- --ARSSHVVL DDDDSSSDDS YYYCCYYYPP -----PGGGG GLELKKKKFF VFG------- --ARAAHVVL DDDDSSTDDS FFFCCYYYPP -----PGGGG GLTLDDDDYW VFPGG----- --YRAAHIIL DDDDSSTDDS FFFCCYYYPP -----GGGGG GLELKKKKYF VFPGG----- --YRAAHIIL DDDDSSTDDS FFFCCYYYPP -----EGGGG GLTLKKKKFW VFPGG----- --YRSSHIIL DDDDSSTDDS FFFCCYYYPP -----PGGGG GIEFPPPPFF LWPGG----- --HRPPHVVL DDDDSSSDDS YYYCCYYYPP -----PGGGG GMQFPPPPFF VFG------- --QRVVHIIL DDDDSSSDDS YYYCCFFFPP -----PGGGG GLSLPPPPFF TVGGG----- --LRPPHIIL DDDDSSSDDS YYYCCYYYPP VVTTTVGGGG GLKLPPPPFL VFGEEPLGGP PPALAAHLLY DDDDSSSDDI WWWII----- VVTTTAGGGG GLKLPPPPFL VFGEEPLGGP PPALAAHLLY DDDDSSSDDI WWWII----- VVTTTVGGGG GLKLPPPPFL VFGEEPLGGP PPALAAHLLY DDDDSSSDDI WWWLL----- VVTTTVGGGG GLTLPPPPFL VFGEEPLGGP PPALAAHLLY DDDDSSSDDI WWWLL----- VVTTTVGGGG GLKLPPPPFL VFGEEPLGGP PPALAAHLLY DDDDSSSDDI WWWII----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVTTTVGGGG GLKLPPPPFL VFGEEPLGGP PPALAAHLLY DDDDSSSDDI WWWII----- VVTTTVGGGG GLKLPPPPFL VFGEEPLGGP PPALAAHIIY DDDDTTSDDI WWWLL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVTTTEGGGG GLKLPPPPFL VFGEEPGGGP PPVLAAHLLY DDDDSSSDDI WWWVV----- VVTTTKGGGG GLKLPPPPFL VFGEEPDGGP PPVLAAHIIY DDDDTTSDDI WWWII----- VVTTTEGGGG GLKIPPPPFF VFGEEPDGGP PPALAAHMMY DDDDTTSDDI WWWII----- VVTTTEGGGG GLKIPPPPFF VFGEEPDGGP PPSLAAHMMY DDDDTTSDDI WWWII----- VVTTTEGGGG GLSIPPPPFF VFGEEPEGGP PPALAAHMMY DDDDTTSDDI WWWII----- GGTTTEGGGG GLTIPPPPFF VFGEEPDGGP PPSLAAHMMY DDDDTTSDDI WWWII----- VVTTTEGGGG GLSIPPPPFF VFGEEPEGGP PPSLAAHMMY DDDDTTSDDI WWWII----- IIPPPEGGGK KMEIRRRRFL IFGIIEGGGP PPYLAAHMMY DDDDTTSDDI WWWII----- VVPPPIGGGH HMVIKKKKFL IFGVVPGGGP PPYLAAHMMY DDDDTTSDDI WWWII----- VVTTTEGGGG GLTVKKKKFL VFGEEPNGGP PPCLAAHIIF DDDDTTSDDI LLLAA----- IIVVVEGGGG GMKLEEEEFL VFGEEPYGGP PPGLPPHMM- ---------- ---------- VVTTTVGGGG GISLEEEEFL VFAEEPYGGP PPSLPPHMMY DDDDTTSDDI WWWLLAAANN ---------- ---------- ---------- ---------- ---------- ---------- KKYYYNDDDG GKELEEEEFA VFYLLGLGG- ---RAAHMMF AAAAYYSSS- ---------- KKYYYYDDDG GKELEEEEFA IFYEEKLGG- ---RPPHMMF AAAAYYAGGP AAAGGDDDGG P------ P------ PVVKK-- PVV---- PVV---- P------ P------ P------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- NAA---- ------- ------- GRRLLVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSAAKKAK QPSAATRTAA VPAAAARRLA AAADGMMMSL LPRRTTTQLL STPPPVIIKA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYQQAAWFSS AQASSPPRRS SKKKSSSSVP PGLLVVISAV KQVSAAAVQQ WWWAAAHGKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------RAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MEEE ---------- ---------- ---------- ---------- ---------- LLLLLLKCLL ---------- ---------- ---------- ---------- ---------- ---------- MMAARRATLP PNTTTPPHHP PLAAPPPPHP PRVVPPTRVR YRTVPRRLPP CCCPPPPSLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------REE ---------- ---------- ---------- ---------- ---------- -------FII ---------- ---------- ---MAPFFFF KRDTPPKMMM AMMKKAEDDL LAYYVACLYT ---------- ---------- -----KLLLL KPDTPPRDDD AMMRRAEDDI IAYYVAALYV ---------- ---------- -----SMMMM RPDTAPELLL AMMQQAEEEF FAYYTLLLSP ---------- ---------- -----TMMMM RPDTAPKLLL AMMEEAENNF FAYYTLLLSP ---------- ---------- -----TLLLL RPDTPAKLLL AMMEEGEKKL LAFFTLMLSP ---------- ---------- -----TWWWW KPDSPPRLLL AAAKKAETTI IAYYVAMFDP ---------- ---------- -----TWWWW RPDTPPRMMM AVVKKAEKKL LAYYVVRLNP ---------- ---------- -----SWWWW RPDTPPKMMM AMMQQAERRL LGYYVALLDP ---------- ---------M MMATKK---- -CGGTLEAAA MKK--GEEEI IVYYLPCIYR ---------- ---------- ---------- ---------- -MM--GEEEI IVYYLPCIYR GALLARRRLL LLLPPGG-AH HHSTQK---- -CGGSLEAAA MKK--GEEEI IVYYLPCIYG ---------- ---------- ---------- ---------- MKK--GEEEI IIYYLPCIYR ---------- ---------M MMATKN---- -CGGTLEAAA MKK--GEEEI IVYYLPCIYR GALLSQQQMM RRRPPIIAST TTATKN---- -CGGTLEAAA MKK--GEEEI IVYYLPCIYR ---------- ---------M MMATKN---- -CGGTLEAAA MKK--G---- ---------- ---------- ---------M MMATKN---- -CGGTLEAAA MKK--GEEEI IVYYLPCIYR GHQQWSSSQQ LLLWWQQEDT TTATKD---- -CGGTQEAAA MKK--GEEEI IVYYLPCIYR FDNNETTTCC TTTLLVVFTS SSPTKN---- -CGGTLEAAA MKK--GEEEI IVYYLPCIYR ---------- ---------M MMATKN---- -CGGTLEAAA MKK--GEEEI IVYYLPCIYR LQMMGAAAEE TTTAAAAAAN NNGKTHTTTT AKGGTLEAAA MEEKKGEKKL LVYYVTCVYN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MAKS---- -CGGSLDAAA MKK--GEEEI IVYYLPCIYR --MMTDDDGG VVVVVNNEKK KKS-VCCCCC KSGGSIESSS MSS--GESSL LIYYVTAVYA --MMTQQQAA VVVVVSSEKV VVNNQCCCCC KSGGSLEAAA MSS--GETTL LIYYVTAVYA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----LQQQQ VGGGTLAAAA MSS--GEKKL LIYYVTAVYT ---------- MMMAAAAAAN NNGAAGGGGG ATGGTLEAAA MEEKKGEKKL LLYYVTCVYN ---------- ---MMSSPNC CCGLKG---- --GGSADAAA IKK--GEEEV VLFFVTAP-- ---------- ---MMPP--C CCPLKG---- --GGSADAAA IKK--GEEEV VLFFVTAP-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MSKCCCC KCGGTLDAAA VRRNNGEKKL LLYYVVCVQP ---------- ---------- ---------- ---------- MRRSSGEKKL LLYYTVTVQP ---------- ---------- ---------- --MGT-DIII LIISSLRFFL LYFFSNWLHG G-------LL AAAAAGG-AL LLAMGFRRRR AFAEQPYMMM PKKIITEEEF FVYYVWTLGV SGMMFRRRLL VVVSSGGLAL LLALAAGGGG VRAEAPYMMM KKKIITEDDY YVYYVWTLGA TGGNRRRVVV NPKSEEYSKK KEELLLLPYI DEEHFWNCSA LLC-GG-KPP NIRRIIVVVP VGGNAAAVVV DPKSPPYGKK KDDLLLLPYI DEEHFWNCSA YYC-AA-KPP FLRRIIVVVP PDS-RRRVVV KPGSSSYGKK KTTMMMMPNT DEEHFWNCSS LLS-TTGHAA FLRRIIIIIP PDS-KKKVVV KPGSPPYGQQ QTTMMMMPNK DEEHFWNCSA LLS-AAGHAA FIRRIIIIIP PDS-KKKVVV DPTSEEFGQQ QIIMMMMPNK DEEHFWNCSA LLS-TTGHAA FLRRIIIIIP PEK-QQQVVV DPASPPYASS SAAMMMMPHA DEEHFWNCSC LLC-AAPHPP HMRRVVVVVP PMN-KKKVVV DSQSSSFGQQ QDDMMMMPYT GEEHFWNCSM LLC-AAPHPP HVRRVVVVVP PGE-RRRVLL DPDSGGYAQQ QEEMMMMPNA DEEHFWNCSA LLC-AAPHPP HVRRIIVVVP RNGEAAATVV DPKSPPYSQQ QPPMMMMPYL DEEHSWNCSC ----FFGDSS TKNNIILLLP RNGEAAATVV DPKSPPYSQQ QPPMMMMPHL DEEHSWNCSC ----FFGDSS TKDDIILLLP GNGEAAATII DPKSPPYCQQ QPPMMMMPNL DEEHSWNCSC ----FFGDSS TKTTMMLLLP RNGEAAATVV DPKSPPYCQQ QPPMMMMPHL DEEHSWNCSC ----YYGDII TKTTVVLLLP RNGEAAATVV DPKSPPYCQQ QPPMMMMPNL DEEHSWNCSC ----FFGDSS TKTTVVLLLP RNGEAAATVV DPKSPPYCQQ Q--------- ---------- ---------- ---------- ---EAAATVV DPKSPPYCQQ QPPMMMMPNL DEEHSWNCSC ----FFGDSS TKTTVVLLLP RNGEAAATVV DPKSPPYCQQ QPPMMMMPNL DEEHSWNCSC ----FFGDSS TKTTVVLLLP RNGEAAATVV DPKSPPYSQQ QPPMMMMPYL DEEHSWNCSC ----FFGDSS TKNNVVLLLP RNGEAAATVV DPKSPPYCQQ QPPMMMMPNL DEEHSWNCSC ----FFGDSS TKTTVVLLLP RNGEAAATVV DPKSPPYCQQ QPPMMMMPNL DEEHSWNCSC ----FFGDSS TKTTVVLLLP NGGNKKKTLL DPSSPPYSQQ QPPVVVVIHI DKKHSWNCSC ----HHGDPP SARRIILLLP ---------- ---------- ---MMMMPNT DEEHSWNCSC ----YYGDAA SKNNIILLLP RSGNKKKTVV DPKSPPYSQQ QPPMMMMPNV DEEHSWNCSC ----YYGDSS SKNNIILLLP AGGEKKKTVV DPSSPPYSKK KPPVVVVPYV DEEHTWNCSC ----HHGDPP SARRIIAAAP AGGEKKKTLL DPNSPPYSKK KPPVVVVPYV DEEHTWNCSC ----HHGDPP SARRIIVVVP ---------- ---------- ---MMMMPFV DEEHSWNCSC ----HHGDAA SARRVVLLLP TGGDKKKTVV DPSSPPYSSS SPPMMMMPFV DEEHSWNCSC ----HHGDAA SVRRVVLLLP NGGNKKKTVV DPNSPPYSQQ QPPVVVVTHV DEEHSWNCSC ----HHGDPP SARRIILLLP --ADGGGTVV NPESDDFCQQ QDDVVVVPHI DEEHTWNCSC ----HHDKPP TESSIIVVVP --ADGGGTVV NPESEEFCQQ QDDVVVVPNI DEEHTWNCSC ----HHDKPP TESSIIVVVP ---------- ---------- ---------- ---------- ---------- ----VVPPPR PNDEHHHTVV DPASPPYCQQ QYYTTTTNSK NEEHSWNCSC HHFVGGGKEE VPDDVVLLLP PNDPHHHTVV DPESPPYCQQ QFFTTTTNRK DEEHSWNCSC YYYVSSSKTT VPDDVVLLLP GDRYDDDNMM VGQVFFGGSS SPPVVVVKVL DKKLSPTRIK ------GKRR VQPPLLQQQL VEMDEEETLL RPGSAARGQQ QSSVVVVGG- NEEHGFS--- ---------- --RRWWTTTG AEVDEEETAA NPKSPPYGKK KSSVVVVGG- NEEHSFT--- ---------- --RRWWAAAG PSSRYYIIII IITPNNPRRE PPKKIEPEEV KKVVYYYYVH HGPIIYAAEE EEEEEGGGGP PSSRYYIIIV VVTPDDKRRR PPAAAEPEVA GGRRYYYYVH HGPIIYAAPD DDEEEGGGGP PSSRYYVVVI IITPHHPTTQ AARRHEPDEI AAKKYYYYVH HGPIIYTTAD DDDDDGGGGA PSSRYYIIII IITPDDPTTK AAKKHEPEEV KKKKYYYYIH HGPIIYTTGD DDNNNGGGGP PSSRYYIIIV VVV-EEPLLK AAKKHEPEEV AAKKYYYYIH HGPIIYTTGD DDDDDGGGGP PSSRYYIIIL LLTPDDPLLK PPFFAEPETL EERRYYYYVH HGPIIYAAAE EEKKKGGGGP PSSHTTIIIL LLTPDDPTTQ PPKKVDPNEL EERRYYYYVH HGPIIYAAPE EEEEEGGGGP PSSRHHIIIV VVTPDDPRRE PPRRVEPEEL RRRRYYYYIH HGPVVYAAPE EEDDDGGGGP PSSRYYVVVV VVVSEEPRRA PPKKHEASEI AAKKVVVVSH HLAEEVNNDL LLNNNGGGGK PSSRYYVVVV VVVSEEPRRA PPKKHEPNEI AAKKLLLLSH HLAEEVSSDP PPNNNGGGGK PSSRYYVVVV VVVSDDPRRA PPKKHEAEDI AAKKLLLLSH HLAEEVSSDS SSNNNGGGGK PSSRYYVVVV VVVTEEPRRA PPKKHEPKDI TTKKLLLLSH HLPEEVSSDP PPNNNGGGGK PSSRYYVVVV VVVSEEPRRA PPKKHEPEDI AAKKLLLLSH HLAEEVSSDV VVNNNGGGGK ---------- ---------- ------PKDI AAKKLLLLSH HLAEEVSSDV VVNNNGGGGK PSSRYYVVVV VVVSEEPRRA PPKKHEPKDI AAKKLLLLSH HLAEEVSSDV VVNNNGGGGK PSSRYYVVVV VVVSEEPRRA PPKKHEPKDI AAKKLLLLSH HLAEEVSSDV VVNNNGGGGK PSSRYYVVVV VVVTEEPRRA PPKKHEAKDI EEKKLLLLSH HLPEEVSSDP PPNNNGGGGK P--------- ---------- ---------- ---------- ---------- ---------- PSSRYYVVVV VVVSEEPRRA PPKKHEPKDI AAKKLLLLSH HLAEEVSSDV VVNNNGGGGK PGGRYYVVVV VVTTDDPRRT PPSSHESEDI EENNLLLLSH HLADDISSDK KKNNNAAAAA PSSRYYVVVV VVVTDDPRRA PPRRHEPYEV WWKKLLLLSH HLGEEISSDP PPNNNGGGGK PSSRYYVVVV VVVSDDPRRA PPRRHEPYEV WWKKLLLLSH HLGEEISSDP PPNNNGGGGK PGGRYYVVVI IITTNNPRRS PPSSHDPADI QQKKLLLLSH HLAEELSSDK KKNNNAAAAE PGGRYYVVVI IITTNNPRRA PPSSHEPEDI TTKKLLLLSH HLAEEISSDK KKNNNAAAAE PGGRYYAAAI IITENNPRRA PPSSYDPKEI EEKKLLLLAH HLAEEISSDE EENNNAAAAK PGGRYYAAAI IITENNPRRA PPSSYDPKEI DDKKLLLLAH HRTEEISSDE EENNNAAAAK PGGRYYVVVV VVTKDDPRRA PPAAHEAEDI EEKKLLLLSH HLAEEISSDK KKNNNAAAAA PDDRYYIIII IIVNEE-RRK IIYYEEPSKL SSLLLLLLSH HLANNISSEA AATTTPPPPS PDDRYYVVVI IIVNEE-RRE IIYYQEPSKL AALLLLLLSH HLANNISSEA AASSSPPPPS RGGVGGKKKV VVVG------ ---------- ---------- ---------- ---------- PDDRFFVVVI IITTDDPRRA PPKKAEG-DV KKGGCCCCTH HLPNNISSDA AANNNAAAAK PDDFYYIIIL LLVTDDPRRK PPEEVDG-DV KKSSVVVVTH HLANNISSDA AAYYYAAAAK LKKRYYVVVT TTSYSSAWWD KKQQY---DL KKFFLLLLAD DQPAALDDES SSVVVPPPPV GNNRFFIIIF FFVSDDPSSN PPKKHDT-FV DDSSVVVVFF FLPMMMGGDD DDGGGGGGGR GSSKFFVVVF FFVSDDPAAR PPVVSTD-FV KKSSVVVVLY YLPMMLGGNK KKGGGGGGGR GGGGGILDSS FEPPGWWIRG QYY------- ------LLAY YYDDFNL-NE LSSSEEEWAA GGGGGILDTT FEPPGWWVRG QYY------- ------FFAY YYDDFNL-SG MSSSEEEWTT PGGGGIMDTT FDVVGWWIRG QDD------- ------KKHY YYDDFNL-RD MSSSEEEWAA PGGGGVMDTT FEVVGWWIRG QTT------- ------LLHY YYDDFNL-RD MSSSEEEWAA PGGGGILDTT FEIIGYYMRG QTT------- ------KKHY YYDDFNL-RD MSSSEEEWGG GGGGGILDSS FEPPGWWVRG QYY------- ------FFAY YYDDGHL-YD LSSSEEEWGG GGGGGILDNN LEVVGWWIRG QYY------- ------LLHY YYDDFHL-YD LSSSEEEWGG GGGGGVMDSS FDPPGWWVRG QQQ------- ------LLAY YYDDFHL-YD MSSSEEEWGG GSSSSFLDTT FEVVGWWKGG SPP------- ------MMGY YYDDFQP-HN MTTTEEEWAA GGGGGFLDTT FEVVGWWKGG APP------- ------MMGY YYDDFQP-HN MTTTEEEWAA GGGGGFLDTT FEVVGWWQGG APP------- ------MMGY YYDDFQP-HN MTTTEEEWAA GGGGGFLDTT FEVVGWWQGG APP------- ------LLGY YYDDFQP-HN MTTTEEEWAA GGGGGFLDTT FEVVGWWRGG APP------- ------SSGY YYDDFQP-HN MTTTEEEWAA GGGGGFLDTT FEVVGWWRGG APP------- ------LLGY YYDDFQP-HN MTTTEEEWAA GGGGGFLDTT FEVVGWWRGG APP------- ------LLGY YYDDFQP-HN MTTTEEEWAA GGGGGFLDTT FEVVGWWRGG APP------- ------LLGY YYDDFQP-HN MTTTEEEWAA GGGGGFLDTT FEVVGWWRGG APP------- ------MMGY YYDDFQP-HN MTTTEEEWAA ---------- ---------- ---------- ---------- ---------- ---------- DGGGGSLLRR LECCG----- ---------- ---------- ---------- -AAAIIISAA GNNNNGLLEE FNVVGGGNLF ISS------- ------KKER RRTTHENYWG FWWWIIIQCC GGGGGFLDTT FEVVGWWAGE APP------- ------FFGY YYDDFQP-HN MTTTEEEWGG GGGGGFLDTT FEVVGWWVGE AQQ------- ------FFGY YYDDFQP-HN MTTTEEEWGG GNNNNGLLDD FNVVGWWKGH PLL------- ------FFGY YYDDFQP-HN MTTTSSSWGG GNNNNGLLEE FNVVGWWKGH PLL------- ------FFGY YYDDFQP-HN MTTTSSSWGG GNNNNGLLDD FNIINWWKGH PLL------- ------FFGY YYDDFQP-HK MTTTSSSWGG GNNNNGLLDD FNIINWWKDI PLL------- ------YYGY YYHHFQP-HK MTTTSSSWGG GNNNNGLLEE FNVVGWWKGH PLL------- ------FFGY YYDDYQP-HK MSSSSSSWGG GNNNNFLDTT FEPPGWWAEK VPP------- ------FFNY YYDDFQP-RN MTTTEEEWGG GNNNNFLDTT FEPPGWWAGK VPP------- ------FFNY YYDDFQP-RN MTTTEEEWGG ---------- ---------- ---------- ---------- ---------- -IIILLLRGG G----DEFNN FELLGWWRDR ALL------- ------CCGY YYDDYQP-FN MSSSEEEWGG G----DLFDD FNCCGWWKDK ALL------- ------CCGY YYDDFQP-FD MSSSEEEWGG LNNNNGTSEE NGLLAGGAQF EII------- ------LLQL LLSSNNG-RE SDDDRRRPDD TAAAALYNGG EYVVTWWPAD MQQGGVGDAA AAADDDYYGY YYDDILI-KN MSSSSSSFTT TAAAALYTGG EYVVTWWPDG LRRGGTG-KK KAADDDYYDY YYDDVLP-KN LSSSSSSFTT V-EEGG-LKE EHHYGGGRHF FWDDLKKKKR RIIHHSSSSL LGGMALL--- --ELRLHHDD V-EEGG-FSE ECCYGGGKHV VWDDLKKRRH HLLYYAAAAI IGGMVLL--- --EVRLHHDD L-EEGG-IVE EDDYGGGRHF FWDDLAARRN NVVQQTTTTI IGGMALL--- --EVRAHHDD L-EEGG-IVE EDDYGGGRHF FWDDLAARRN NVVQQTTTTI IGGMALL--- --EVRAHHDD L-EEGG-IVE EDDYGGGKHF FWKKLDDKKN NVVQQTTTTI IGGMALL--- --EIRAHHDD T-EEGG-LVD DIIYGGGRHF FWDDLRRRRH HLLQQEEEEI IGGLVFF--- --ELRAHHDD T-EEGG-VLD DEEYGGGRHV VWDDLRRRRH HLLQQTTTTL LGGMALL--- --ELRAHHDD T-EEGG-LDQ QIIYGGGRHI IWDDLRRRRH HLLQQAAAAL LGGMVLL--- --ELRAHHDD A-KKGGFNPH HVVYGGGRFV VWDDWRREEI IIIQQTTTTL LTTLIPP--- -LEIRLHHDD A-KKGGFNPH HVVYGGGHHV VWDDWRREEI IIIQQTTTTL LKKLIPP--- -LEIRLHHDD A-RRGGFNPD DVVYGGGHHV VWDDWRREEI IIIQQTTTTL LQQLIPP--- -LEIRLHHNN A-RRGGFNPD DVVYGGGHYV VWDDWRREEI IVVQQTTTTL LQQLIPP--- -LEIRLHHNN A-RRGGFNPD DVVYGGGHYV VWDDWHHEEI IVVQQTTTTL LKKLIPP--- -LEIRLHHNN A-RRGGFNPD DVVYGGGHYV VWDDWRREEI IVVQQTTTTL LKKLIPP--- -LEIRLHHNN A-RRGGFNPD DVVYGGGHYV VWDDWRREEI IVVQQTTTTL LKKLIPP--- -LEIRLHHNN A-RRGGFNPD DVVYGGGHYV VWDDWRREEI IVVQQTTTTL LKKLIPP--- -LEIRLHHNN A-QQGGFNPD DVVYGGGHHV VWDDWRREEI IVVQQTTTTL LPPHIPP--- -LEIRLHHDD ---------- ---------- ---------- ---------- ---------- ---------- H-LLGGSRDP PAAVAAAI-- ---------- ---------- ---------- ---------- C-TTGGAELC CLLVHHHICL LDNNYMMVVI IDDEESSSSL LQQAGAANNN NLCLRIHHWW A-AAGGFKME EVVYGGGSNV VWDDWEERRR RIIQQTTTTI IGGLIPP--- -LEIRLHHDD A-AAGGFKMD DVVYGGGSNV VWDDWEERRL LVVQQTTTTI IGGLIPP--- -LEIRLHHNN A-TTGGFDLH HVVYGGGHTC CIQQLRREEL LRRQQTTTTL LGGLLPP--- -LEIRLHHDD A-LLGGFNLH HVVYGGGHHV VYSSWGGEEI IKKQQTTTTL LGGLLPP--- -LEIRLHHDD A-SSGGFDLH HVVYGGGHHV VYSSWGGEEM MKKQQLLLLI IGGLLPP--- -LEIRLHHDD A-SSGGFNLH HVVYGGGHHV VYSSWGGEEI IKKQQLLLLI IGGLLPP--- -LEIRLHHDD A-RRGGFDLH HVVYGGGHHV VYDDWGGEEL LKKQQTTTTL LGGLLPP--- -LEVRLHHDD S-KKGGFNPH HVVYGGGSHI IFEEWSSKKY YLLQQTTTTI IPPALPP--- -LEVRLHHEE S-KKGGFNPH HVVYGGGSHI IFEEWTTKKH HLLQQTTTTI IPPALPP--- -LEVRLHHEE G-CCDDEELC CQQVIIICRV VY-------- ---------- ---------- ---------- A-RRGGYHPD DCCYGGGRNF FYRRWEEEEL LFFQQTTTTI IGGLTPP--- -LEIRLHHNN A-RRGGWKND DLLYGGGRNF FYKKWTTTTL LYYQQTTTTI IGGITPP--- -LEIRLHHNN E-FFSSSESL LKKKPPPHAE EVLL------ ---------- ---------- ---------- GYDDGGQMLD DAAFGGGTVQ QWDDLTTQQP PKKKKVVVVF FPP------- -LEIRPWWGG GYDDGGKMLD DPPFGGGTVT TWDDLTTQQP PKKKKVVVVF FPP------- -LEIRAWWGG DPPTKKLLMG GIMVVLLKLL SSSILLFFYY --EKWNAEEE KIEIPPPPLE LEIFFAAPPI DPPTKKLLMG GVVVLTTKLL SSSILLFFYY --EKWQAEEE RIDIEPPPFE LPVFFMMPPI DPPVRREEYG GVVVVTTTLL ESSITTWWRR --EKFHVKKK KATIPPPPAT LPLFFAAPPI DPPVRREEYG GVVVVTTTLL ESSITTWWRR --EKFHAEEE KATIPPPPAP LPLFFAAPPI DPPSKKDDYG GCVVVTTTLL QAAITTWWQQ KKDTFEAKKK KITIDPPPAD LDLFFAAPPI DPPTKKAAYG GVCVILLKLL SSSITTYYRR --DKWAVRRR KIEIPAAAAD LPVFFAAPPI DPPTKKAAYG GMCVVLLKLL SSSILLYYRR --DSWHLKKK KIDIPPPPAS LPIFFAAPPI DPPARRTTYG GVVVVLLELL SSSVLLHHRR --QSWGIRRR KIEIPPPPAE LPLFFAAPPI DPPSAATTQG GVCALSSNQQ RYYKEEGG-- ---------- -TWSVVVVIQ KVKLLEEPGI DPPDAATTQG GVCALSSNQQ RYYKEEGG-- ---------- -TWSVVVVIQ KVKLLEEPGI NPPDAAAAQG GVCALSSTQQ RYYKQQGG-- ---------- -TWSVVVVIQ KVKLLEEPGI NPPDAAAAQG GVCALSSTQQ RFFKEEGG-- ---------- -TWSAVVVIQ KVKLLEEPGI NPPDAAAAQG GVCALSSTQQ RYYKEEGG-- ---------- -TWSVVVVIQ KVKLLEEPGI NPPDAAAAQG GVCALSSTQQ RYYKEEGG-- ---------- -TWSVVVVIQ KVKLLEEPGI NPPDAAAAQG GVCALSSTQQ RYYKEEGG-- ---------- -TWSVVVVIQ KVKLLEEPG- NPPDAAAAQG GVCALSSTQQ RYYKEEGG-- ---------- -TWSVVVVIQ KVKLLEEPGI DPPAAASSQG GVCALSSTQQ RYYKEEGG-- ---------- -TWSVVVVIE KVKLLEEPGI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WKKNIINNQD DDVEVFFSRR GSSDDDYY-- ---------- -AVVLKKKLD AVAVVSSSNA DPPDAAAAQG GVCALSSTFF RYYKKKGG-- ---------- -KWAAVVVIK KVELLEEPGI NPPDAADDQG GVCALSSSFF RYYKKKGG-- ---------- -KWAAVVVIQ KVEMMEEPGI DPPAKKDDTG GVSALSSNII RFFKQQGG-- ---------- -SWSHAAAIP LVQLLEEPGF DPPAKKDDTG GVSALSSNII RFFKQQGG-- ---------- -SWNHVVVIS LVQLLEEPGF DPPSKKDDTG GVSALSSNII RFFKSSDD-- ---------- -TWSYVVVIS LVELLEEPGF DPPSKKDDTG GVSALSSNII RFFKSSEE-- ---------- -TWSHVVVIS LVELLEEPGF DPPSKKDDTG GVCALSSNVV RFFKAAGG-- ---------- -SWSHAAAIS LVRLLEEPGF EPPTSSEEHA AVCALSSGFF RHHPEENNSS ---------- TTHAAVVVAF KVSLLEEPAI EPPTSSEEHA AVCALSSAFF RHHPEENNPP ---------- KVQTAVVVAT KVELLDDPAI ---------- ---------- ---------- ---------- ---------- ---------- NPPREENNQG GVCAFXXXXX XXX------- ---------- ---------- -GEIIMMGGI NPPKKKAAEG GVCALAAKFF HKKKSSSSDD ---------- EEAKKDDDIP VTGAADDGGI ---------- ---------- ---------- ---------- ---------- ---------- GSSNAANNYA ASTALSSQWW LYYEDDGG-- ---------- ---------E KVANNAAIPI GEEAHHNNYC CTTALSSQWW LYYEGGGG-- ---------- ---------E KVAEEAAVPI DSSDDDDKFF LLLLLWWWWG GGVQQYSNPP FFPPPVLLLG GKGGGIFFRR RADDDHP--- DSSDDDDRFF LLVLLWWWWG GGLQQYTNPP HHPPPRLLLG GRGGGLYYRR REPPPHP--- DSSDDDDRFF LLVCCWWWWG GGMQQYSDPP HHPPPVLLLG GSGGGIAARR RAPPPHP--- DSSDDDDRFF LLVCCWWWWG GGMQQYSDPP RRPPPKLLLG GSGGGIAARR RTPPPHP--- DSSDDDDKYY LLVCCWWWWG GGMQQYSDPP MMPPPVLLLG GKGGGIVVKK KTPPPHP--- DSSDDDDRFF LLVCCWWWWG GGLQQYSDPP FFPPPKLLLG GKGGGIVVRR RATTTHP--- NSSDDDDRFF LLVCCWWWWG GGLQQYSDPP FFPPPRLLLG GKGGGIVVRR RAGGGHP--- NSSDDDDRFF LLVCCWWWWG GGLQQYSDPP FFPPPRHHHG GSGGGIVVKK KAAAAHP--- LSSDDDDRFF LLFNNWWWWL GGIQQYSNPP QQPPPRLLLG GQGGGSIIRR RGGGGSVVVD LSSDDDDRFF LLFNNWWWWL GGIQQYSNPP KKPPPRLLLG GQGGGSIIKK KGGGGSVVVD LSSDDDDRFF LLFNNWWWWL GGLQQYSDPP QQPPPRLLLG GQGGGSIIKK KGGGGPVVVD LSSDDDDHFF LLFNNWWWWL GGIQQYSDPP QQPPPRLLLG GQGGGSIIKK KDGGGPVVVD LSSDDDDRFF LLFNNWWWWL GGLQQYSDPP QQPPPRLLLG GQGGGSIIKK KGGGGPVVVD LSSDDDDRFF LLFNNWWWWL GGLQQYSDPP QQPPPRLLL- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LSSDDDDRFF LLFNNWWWWL GGLQQYSDPP QQPPPRLLLG GQGGGSIIKK KGGGGPVVVD LSSDDDDRFF LLFNNWWWWL GGMQQYSDPP KKPPPRLLLG GQGGGSIIKK KGGGGPVVVD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WFFSSSSLLL IIFSS----- ---------- ---------- ---------- ---------- LSSDDDDRFF LLFNNWWWWL GGIQQYTDPP RRPPPKLLLG GQGGGSIIRR RGGGGPVVVD LSSDDDDRFF LLFNNWWWWL GGIQQYTDTT RRPPPKLLLG GQGGGSIIRR RGGGGPVVVD LSSDDDDRFF LLFNNWWWWL GGIQQYEDLL KKPPPVLLLG GQGGGLIIKK KGSSSPVAAE LSSDDDDRFF LLFNNWWWWL GGIQQYEDVV KKPPPKLLLG GQGGGLIIKK KGSSSPVAAD LSSDDDDRFF LLFNNWWWWL GGIQQYEDPP KKPPPVLLLG GQGGGLLLKK KGSSSPVAAE LSSDDDDRFF IIFNNWWWWL GGIQQYEDPP KKPPPVLLLG GQGGGLLLKK KGSSSPVAAE VSSDDDDRYY LLLNNWWWWL GGIQQYEDPP AAPPPVLLLG GQGGGLLLKK KGSSSEVYYE LSSDDDDRFF LLVCCWWWWL GGIQQYSDPP LLVVVKLLLS SQGGGSVVTT TESSSNVVVG LSSDDDDRFF LLVCCWWWWL GGIQQYSDPP KKPPPKLLLS SQGGGSIISS SETTTTVVVE ---------- ---------- ---------- ---------- ---------- ---------- LSSDDDDRYY LLFNNWWWWR GGVQQYSDRR AAPPPRLLLG GQGGGAIIRR RDAAAPRVVD ISSDDDDRFF LLVCCWWWWR GGVQQYTDPP EEPPPKLLLG GQGGGAIISS SDLLLPNIID ---------- ---------- ---------- ---------- ---------- ---------- SAADDDDQTT LLISSFFFFM GGTLLFSDPP HHPPPFQQQY YERRRQVV-- ---------- SSSDDDDSRR LLVTTFFFFM GGTLLFSDPP HHPPPRQQQY YEAAAQVV-- ---------- ---------- --AGGKLLTT GAPPLIIISS SSRDGGRRVV VVTSYYSTTN QFYYPPELWW ---------- --SGGEAATT GAPPIVVVSS SSRDGGRRVV VITSYYSSSN QFYYPP-LWW ---------- --NGGTFFAA GGPPVIIISS SSRDGGRRVV VWTSYYSTTD QFYYPPDVAA ---------- --NGGAFFAA AGPPVIIISS SSRDGGRRVV VWTSYYSTTD QFYYPPDVVV ---------- --NGGTFFGG YGPPVIIISS SSRDGGKRVV VWTSYYSTTE QFYYPPGRAA ---------- -AKNNALLNN GGPPVIIISS SSRDGGRRVV VFTSYYGAAP QFYYPPEIWW ---------- -ATSSELLNN GGPPVIIISS SSRDGGRRVV VFTSYYRAAE QFYYPPDIWW ---------- --ASSPLLNN GGPPVVVVSS SSRDGGRRVV VFSSYYASSE QFYYPPVIWW DQEELLCCCE EVKGGRIIPP GGPPILLLSS SSLDGGKRLL LATSYYSDDK QFYY--PLEE DQEELLCCCE EVKGGRVVPP GGPPILLLSS SSLDGGKRLL LVTSYYSAAK QFYY--PLEE DQEELLSSSE EVKGGKVVPP GGPPILLLSS SSLDGGKRLL LVTSYYSAAK QFYY--PLEE DQEELLSSSE EVKGGQVVAA GGPPILLLSS SSLDGGKRLL LVTSYYSAAK QFYY--PLEE DQEELLSSSE EVKGGRVVAA GGPPILLLSS SSLDGGKRLL LITSYYSAAK QFYY--PLEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DEEELLSSSE EVKGGRVVAA GGPPILLLSS SSLDGGKRLL LITSYYSAAK QFYY--PLEE DQEELLSSSE EVKGGRVVPP GGPPILLLSS SSLDGGKRII IVTSYYSDDK QFYY--PLEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DKDDLLCCCD DVKGGKVVPP GGPPILLLSS SSLDGGKRLL LVTSYYSKKK QFYY--PMEE DKEELLCCCD DVKGGIIIPP GGPPILLLSS SSLDGGKRII IVTSYYSIIK QFYY--PLEE EDGGKKWWWD DIQGGKLLRR GGPPILLLTT TTLDGGKRLL LVTSFFSAAK QFYY--PLKK DDGGEEWWWD DIQGGKLLRR GGPPILLLSS SSLDGGKRLL LVTSFFSAAK QFYY--PLQQ EDGGNNFFFD DIKGGSLLRR GGPPILLLSS SSLDGGKRLL LATSFFSAAR QFYY--PLKK EDGGNNFFFE EIKGGSLLRR GGPPILLLSS SSLDGGKRLL LATSFFSAAV SFYY--PIKK EDDDKKEEES SVKGGRLLRR GGPPILLLSS SSLDGGKRII IVTSFFSRRE QFYYGGQLKK GEKK-----E EVKGGKIIEE GGPPLLLLSS SSLDGGKRLL LVTSYYKKKD QFYY--PHSS EDHHDD---P PVKGGQIIEE GGPPLLLLSS SSLDGGKRLL LVSSYYKKKD QFYY--PNSS ---------- ---------- GGPPILLLSS SSVDGGKRLL LVTSYYSTTK QFYY--PVEE DPEELLEEEE ELKGGRLLLL GGPPLLLLSS SSLDGGRRLL LVSSFFSPPK QFYY--PMAA DKEELLEEEP PVKGGRLLEE GGPPLLLLSS SSLDGGKRLL LVSSYYSPPK QFYY--PMQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----VQQQSS SSWDGGKRVV VFSSLLANN- --------KK ---------- ---------- ----VSSSSS SSWDGGQRLL LYTSLLANN- --------KK MVKLNAANN- -SGGLLEDKK KKKEFFVDDF E-----AARR SVLSGGGDDD AASSDDSYY- MAKVNVVNN- -EGGLLEEKK KKKEFFVDDF R-----AARR AVLWGGGDDD AASTDDSFY- QVLAHAAGG- -DGGLLTADD DDDDYYVEEF DG----YYRR AILEGGGDDD CCSTDDSFYS EVMANVVGG- -NGGLLEDKK KKKDYYVSSF DG----YYRR AILEGGGDDD CCSTDDSFYS MVMANVVGG- -NGGLLTDKK KKKDFFVDDF AG----YYRR SILEGGGDDD CCSTDDSFYS MVKLDAAGG- -NGGIIEDPP PPPKFFLEEW KG----HHRR PVLQGGGDDD CCSSDDSYY- MVKVDVVNN- -DGGMMQDPP PPPNFFVDDF E-----QQRR VILQGGGDDD AASSDDSYF- IAKAEAADD- -GGGLLSDPP PPPGFFTEEV DG----LLRR PILEGGGDDD SSSSDDSYYS GSVMLQQVVD DNGGLLKNPP PPPNFFVDDF KEPGPPAALL ALYPGGGDDD CCSSDDIW-- GSVMLQQIID DNGGLLKNPP PPPNFFVDDF KEPGPPAALL ALYPGGGDDD CCSSDDIW-- GSVMLQQIID DKGGLLKNPP PPPNFFVDDF KEPGPPAALL ALYPGGGDDD CCSSDDIW-- GSVMLQQIID DKGGLLTNPP PPPNFFVDDF KEPGPPAALL ALYPGGGDDD CCSSDDIW-- GSVMLQQVVD DKGGLLKNPP PPPNFFVDDF KEPGPPAALL ALYPGGGDDD CCSSDDIW-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSVMLQQVVD DKGGLLKNPP PPPNFFVDDF KEPGPPAALL ALYPGGGDDD CCSSDDIW-- GSVMLQQIID DKGGLLKNPP PPPNFFVDDF KEPGPPAALL AIYPGGGDDD CCTSDDIW-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSVMLQQIID DKGGLLKNPP PPPNFFVDDF KEPGPPVVLL ALYPGGGDDD CCSSDDIW-- GAVMLQQIID DKGGLLKNPP PPPNFFVDDF KEPGPPVVLL AIYPGGGDDD CCTSDDIW-- GSHILQQIID DKGGLLKNPP PPPNFFVDDF AEPGPPAALL AMYPGGGDDD CCTSDDIW-- GSHILQQIID DNGGLLKNPP PPPNFFVDDF AEPGPPSSLL AMYPGGGDDD CCTSDDIW-- GSHIIQQIID DKGGLLSNPP PPPNFFVDDF DEPGPPAALL AMYPGGGDDD CCTSDDIW-- GSHIIQQIID DKGGLLTNPP PPPDFFVDDF DEPGPPSSLL AMYPGGGDDD CCTSDDIW-- GSHMLQQIID DKGGLLSNPP PPPNFFVDDF AEPGPPSSLL AMYPGGGDDD CCTSDDIW-- GATMVQQVVN DSGKMMENRR RRRDFFIDDF KIEGPPYYLL AMYPGGGDDD CCTSDDIW-- GATMLQQIID DTGHMMVNKK KKKNFFIDDF KVPGPPYYLL AMYPGGGDDD CCTSDDIW-- GSVMLQQIID DKGGLLTNKK KKKNFFVDDF KEPGPPCCLL AIFPCCGDDD SSTSDDIL-- GGTIVQQLLD DNGGMMKNEE EEENFFVDDF GEPGPPGGLL PM-------- ---------- GGHIVLLIID DNGGIISNEE EEEDFFVDDF NEPGPPSSLL PMYPGGGDDD CCTSDDIWAD ---------- ---------- ---------- ---------- ---------- ---------- GKDDAQQYYL AWDGKKEVEE EEEDFFVDDF ELGG----RR AMFGSSSAAA LLYSSS---- GKDDEQQFFL LWDGKKEKEE EEEQFFIDDF AEKG----RR PMFGAARAAA LLYAGGPADN ------- ------- SSS---- SSS---- SSS---- ------- ------- SSS---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- DDD---- ------- ------- NNNQRVV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NSSSAAKKAK QPSSSATTPR AAVVVGLTAA RADGQSLPTA QLLSLLLTGG SPVRIKAYQA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -------MAR gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AWTSSSAIVV LASSPPSSES KKGGRKKRRR VLVESAAAAV VVVVVPPSAA HHPGGAAVLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --ERGAFTLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMKEGHTAQQ ---------- ---------- ---------- ---------- --------LL KKGCFDQTNN ---------- ---------- ---------- ---------- ---------- ---------- SAPLLPPLNN RTPPPPPPNP LLAAPAAPPP HVPLRVVPPT IIIIINNVPP PPHSLQHIMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM ---------- ---------- ---------- ---------- ---------- --------MM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --RRG----- ---------- ---------- ---------- ---------- ---------- --RFSGPSMM ---------- -----MAVPP PKKRFFFPPP KKMAAAPEED LLAAACYYTT GNNRAADDFF ---------- -------AKK KKKPFFFPPP RRDAAAPEED IIAAAAYYTT GNNAPPDDFF ---------- -------MSS SRRPFFFAPP EELAAAAEEE FFALLLSSFF S--RPPDDAA ---------- -------MTT TRRPFFFAPP KKLAAAAEEN FFALLLSSFF S--KPPDDAA ---------- -------MTT TRRPFFFPAA KKLAAGVEEK LLALLMSSAA S--KPPDDGG ---------- -------ATT TKKPFFFPPP RRLAAAPEET IIAAAMDDRR K--QPPDDAA ---------- -------VTT TRRPFFFPPP RRMAAAAEEK LLAVVRNNAA N--KPPDDAA ---------- -------ASS SRRPFFFPPP KKMAAAREER LLGAALDDRR E--RPPDDAA ---------- ---AATKTKK K--CYYYTLL EEAMMGREEE IIVPPCYYTT GEEAPPDDYY ---------- ---------- ---------- -----GREEE IIVPPCYYTT GEEAPPDDYY IIIAPPPAAL LLGSSTQGKK K--CYYYSLL EEAMMGREEE IIVPPCYYTT GEEAPPDDYY ---------- ---------- ---------- ---MMGREEE IIIPPCYYTT GEEAPPDDYY ---------- ---AATKGNN N--CYYYTLL EEAMMGREEE IIVPPCYYTT GEEAPPDDYY QQQSVVVAAM MMIAATKGNN N--CYYYTLL EEAMMGREEE IIVPPCYYTT GEEAPPDDYY ---------- ---AATKGNN N--CYYYTLL EEAMMG---- ---------- -EEAPPDDYY ---------- ---AATKGNN N--CYYYTLL EEAMMGREEE IIVPPCYYTT GEEAPPDDYY PPPWFFFLLQ QQQAATKGDD D--CYYYTQQ EEAMMGREEE IIVPPCYYTT GEEAPPDDYY TTTELLLHHC CCVPPTKGNN N--CYYYTLL EEAMMGREEE IIVPPCYYTT GEEAPPDDYY ---------- ---AATKGNN N--CYYYTLL EEAMMGREEE IIVPPCYYTT GEEAPPDDYY EEEGAAAAAE EEAGGKTCHH HAAKYYYTLL EEAMMGREEK LLVTTCYYTT GNNKLLDDYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMAKGSS S--CYYYSLL DDAMMGREEE IIVPPCYYTT GNNKPPDDYY AAATVVVLLG GGNSS-VGCC CKKSYYYSII EESMMGREES LLITTAYYTT GEEKPPDDYY GGGTVVVLLA AASNNNQGCC CKKSYYYSLL EEAMMGREET LLITTAYYTT GEEKPPDDYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MLL LVVGYYYTLL AAAMMGSEEK LLITTAYYTT GDDKPPDDYY ---------- --AGGAACGG GAATYYYTLL EEAMMGREEK LLLTTCYYTT GNNKPPDDYY ---------- --SGGLKHGG G---YYYSAA DDAIIGREEE VVLTTA--NN ADDGPPDDAA ---------- --PPPLKHGG G---YYYSAA DDAIIGREEE VVLTTA--HH ADDGPPDDAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MSSKK KKKCYYYTLL DDAVVGVEEK LLLVVCQQLL DEEHGGDDYY ---------- ---------- ---------- ---MMGREEK LLLVVTQQLL DPPHGGDDYY ---------- ---------- ----LLLT-- DDILLLDRRF LLYNNWHHII RYYDIITTDD ---------L LLGAAMGPFF FAAFTTTQPP YYMPPTQEEE FFVWWTGGGG MDDEQQDDKK HHHFAAALLL LLGAALAPAA AVVRTTTAPP YYMKKTQEED YYVWWTGGGG VDDEQQDDKK FIANETSKKH EEELPYNNEE ELFWWNACSS ACNNNGG-KI FLIIIPPLRR RSRRIDDTTT FLADPTGKKY DDDLPYGGEE ELFWWNACSS ACNNNAA-KL YLIIIPPLRR RSRRIDDTTT ALAKSTGKKH TTTMPNGGEE EFFWWNACSS SSLLLTTGHL FLIIIPPLRR RSRRIDDTTT ALAKPTGQQH TTTMPNGGEE EFFWWNACSS ASLLLAAGHI YLIIIPPLRR RSRRIDDTTT GLADEKGQQH IIIMPNGGEE EFFWWNACSS ASLLLTTGHL YLIIIPPIRR RSRRIDDVVV AIADPRASSG AAAMPHGGEE ELFWWNACSS CCNNNAAPHM YLVVVPPLRR RSRRIDDTTT AMCDSTGQQG DDDMPYGGEE ELFWWNACSS MCNNNAAPHV YLVVVPPIRR RSHHIDDTTT ALGDGTAQQG EEEMPNAAEE ELFWWNACAA ACYYYAAPHV YLIIIPPIRR RSRRIDDTTT YLADPQSQQH PPPMPYKKEE ELSWWNTCSS C----FFGDK KLIIIPPLMM MSRRIDDVVV YLADPHSQQH PPPMPHKKEE ELSWWNTCSS C----FFGDK KLIIIPPIII ISRRIDDVVV YLADPQCQQH PPPMPNRREE ELSWWNACSS C----FFGDK KLMMMPPLMM MSRRIDDVVV YLADPQCQQH PPPMPHKKEE ELSWWNTCSS C----YYGDK KLVVVPPLII ISRRIDDVVV YLADPQCQQH PPPMPNKKEE ELSWWNTCSS C----FFGDK KLVVVPPLII ISRRIDDVVV YLADPQCQQE ---------- ---------- ---------- ---------- ---------- YLADPQCQQH PPPMPNKKEE ELSWWNTCSS C----FFGDK KLVVVPPLII ISRRIDDVVV YLADPQCQQH PPPMPNKKEE ELSWWNTCSS C----FFGDK KLVVVPPLII ISRRIDDVVV YLADPQSQQH PPPMPYKKEE ELSWWNTCSS C----FFGDK KLVVVPPFII ISRRIDDVVV YLADPQCQQH PPPMPNKKEE ELSWWNTCSS C----FFGDK KLVVVPPL-- ---------- YLADPQCQQH PPPMPNKKEE ELSWWNTCSS C----FFGDK KLVVVPPLII ISRRIDDVVV YLADPTSQQH PPPVIHGGKK KLSWWNSCSS C----HHGDA FLIIIPPLLL LSRRVDDTTT ---------- ---MPNNNEE ELSWWNTCSS C----YYGDK KLIIIPPLII ISRRIDDVVV YLADPSSQQH PPPMPNNNEE ELSWWNTCSS C----YYGDK KLIIIPPLII ISRRIDDVVV YLADPTSKKH PPPVPYGGEE ELTWWNSCSS C----HHGDA FLIIIPPLVV VSRRIDDTTT YLADPTSKKH PPPVPYGGEE ELTWWNSCSS C----HHGDA FLIIIPPIVV VSRRVDDTTT ---------- ---MPFGGEE ELSWWNSCSS C----HHGDA YLVVVPPLII ISRRIDDTTT YLADPSSSSH PPPMPFGGEE ELSWWNSCSS C----HHGDV YLVVVPPLII ISRRIDDTTT YLGDPTSQQH PPPVTHGGEE ELSWWNACSS C----HHGDA FLIIIPPLLL LSRRVDDTTT AIFNDTCQQS DDDVPHGGEE EVTWWNACSS C----HHDKE HLIIIPPLNN NSRRINNVVV AIFNETCQQS DDDVPNGGEE EVTWWNACSS C----HHDKE HLIIIPPLNN NSRRINNVVV ---------- ---------- ---------- ---------- -MVVVRRLSS SSVVEFFVVV YLADPTCQQH YYYTNSHHEE ELSWWNTCSS CF---GGGKP RLVVVPPLNN NSRRIDDTTT YLSDPTCQQH FFFTNRGGEE ELSWWNACSS CYEEESSSKP RLVVVPPLNN NSFFIDDVVV DRKVFLGSSK PPPVKVEEKK KESPPTPRLL K------GKQ QMLLLLLLDD DGRRLTTSSS KLVRATGQQN SSSVGGRREE EAGFFSA--- ---------- FFWWWGGLDD DTRRIDDVVV KLVNPQGKKN SSSVGGRREE EASFFTD--- ---------- YLWWWGGLDD DTKKIDDVVV TKNPPRRREE IKKKKVVEEP PEEEVKKSSS SLLHHVHCPP DDAYILEE-- --EGGGLLMD TKDKKRRRRR AKKKKIIEEP PEVVAVGTTT TYYHHVHCPP DDAYILPP-- RREGGGFFLD TKHPPTTTQQ HKKKKIIEEP PDEEILATTS SPPHHVHCPP EEGYVLAAGG TTDGGPFFID TKDPPTTTKK HKKKKIIEEP PEEEVFKTTS SPPHHIHCPP DDGYVLGGGG TTNGGPFFID VKEPPLLLKK HKKKKIIEEP PEEEVFATTS SPPHHIHCPP EEGYVLGGGG TTDGGPFFID TKDPPLLLKK AKKKKVVEEP PETTLAETTS SPPHHVHCPP GGGYVLAA-- --KGGGAAMD TKDPPTTTQQ VKKKKVVDDP PNEELAETTA APPHHVHCPP DDGYILPP-- --EGGGFFID TKDPPRRREE VKKKKVVEEP PEEELHRTTS SPPHHIHCPP DDGYVLPP-- --DGGGFFVD VGEPPRRRAA HKKKKVVEEA ASEEIQACCS STTHHSHCAA SSGVMTDD-- GGNGGGVVLD VGEPPRRRAA HKKKKVVEEP PNEEIHACCG GLLHHSHCAA SSGVMSDD-- GGNGGGVVLD VGDPPRRRAA HKKKKVVEEA AEDDIHACCG GVVHHSHCAA SSGVMTDD-- GGNGGGVVLD VGEPPRRRAA HKKKKVVEEP PKDDIHTCCG GFFHHSHCPP SSGVMTDD-- GGNGGGVVLD VGEPPRRRAA HKKKKVVEEP PEDDIHACCA ALLHHSHCAA SSGVMSDD-- GGNGGGVVLD ---------- ---------P PKDDIHACCA ALLHHSHCAA SSGVMSDD-- GGNGGGVVLD VGEPPRRRAA HKKKKVVEEP PKDDIHACCA ALLHHSHCAA SSGVMSDD-- GGNGGGVVLD VGEPPRRRAA HKKKKVVEEP PKDDIHACCA ALLHHSHCAA SSGVMSDD-- GGNGGGVVLD VGEPPRRRAA HKKKKVVEEA AKDDIHECCG GPPHHSHCPP TTGVMTDD-- GGNGGGVVLD ---------- ---------- ---------- ---------- ---------- ---------- VGEPPRRRAA HKKKKVVEEP PKDDIHACCA ALLHHSHCAA SSGVMSDD-- GGNGGDLLVL TADPPRRRTT HKKKKVVEES SEDDIAEIIG GPPHHSHCAA SSGIMCDD-- GGNAAGFFLL VGDPPRRRAA HKKKKTTEEP PYEEVFWCCA ALLHHSHCGG CCGIMSDD-- GGNGGGVVLD VGDPPRRRAA HKKKKTTEEP PYEEVFWCCA APPHHSHCGG CCGIMSDD-- GGNGGGVVLD TKNPPRRRSS HKKKKVVDDP PADDIIQTTA APPHHSHCAA SSGLMCDD-- GGNAAGFFLL TKNPPRRRAA HKKKKVVEEP PEDDISTTTA APPHHSHCAA SSGIMCDD-- GGNAAGFFLL TKNPPRRRAA YKKKKYYDDP PKEEIAETTA APPHHAHCAA SSGILCDD-- GGNAAGFFLL TKNPPRRRAA YKKKKYYDDP PKEEIADTTA APPHHAHCTT --GILCDD-- GGNAAGLLLL TLDPPRRRAA HKKKKVVEEA AEDDIAETTG GPPHHSHCAA SSGIMCDD-- GGNAAGFFLL VEE--RRRKK EHHHHTTEEP PSKKLHSNNS SPPHHSHCAA DDGIMTEE-- GGTPPGLLLD VEE--RRREE QHHHHTTEEP PSKKLHANNS SPPHHSHCAA DDGIMTEE-- GGSPPGLLLD VG-------- ---------- ---------- ---------- ---------- ---------- TGDPPRRRAA AKKKKVVEEG G-DDVLKAAT TPPHHTHCPP NNGIMIDD-- GGNAAGFFVF VVDPPRRRKK VKKKKTTDDG G-DDVLKHHT TPPHHTHCAA NNGIMVDD-- GGYAAGFFIF SLSAAWWWDD YPPPP----- --DDLIKLLA ASSHHADYPP NNTLKGEE-- SSVPPLIIQS VHDPPSSSNN HKKKKTTDDT T-FFVKDGGV VPPHHFFAPP GGSMILDD-- HHGGGTVVEN VHDPPAAARR SKKKKTTTTD D-FFVEKGGV VPPHHLYAPP GGRLILNN-- HHGGGTVVET DFFPLLKIII DRGGGGGQQQ Q--------- -----AYFWW WWNLLLNVLV SSSEWAAAVP DFFPIIRVVV YRGGGGGQQQ Q--------- -----AYFWW WWNLLLSVMI TSSEWTTTVP DFFVLLRIII DRGGGGGQQQ Q--------- -----HYFWW WWNLLLRYMV SSSEWAAALP DFFVLLRIII DRGGGGGQQQ Q--------- -----HYFWW WWNLLLRYMV TSSEWAAALP DFFILLRMMM DRGGGGGQQQ Q--------- -----HYFWW WWNLLLRYMV SSSEWGGGLP DFFPLLRVVV ERGGGGGQQQ Q--------- -----AYGWW WWHLLLYTLV TSSEWGGGTP DLLVLLRIII DRGGGGGQQQ Q--------- -----HYFWW WWHLLLYTLL TSSEWGGGTP DFFPLLRVVV ERGGGGGQQQ Q--------- -----AYFWW WWHLLLYTMV TSSEWGGGTP DFFVKKTKKK PGGGGGGSSS S--------- -----GYFWY YYQPPPHVMV STTEWAAAAP DFFVKKTKKK PGGGGGGAAA A--------- -----GYFWY YYQPPPHIMV STTEWAAAAP DFFVKKTQQQ PGGGGGGAAA A--------- -----GYFWY YYQPPPHVMI STTEWAAAAP DFFVKKTQQQ PGGGGGGAAA A--------- -----GYFWY YYQPPPHVMI STTEWAAAAP DFFVKKTRRR PGGGGGGAAA A--------- -----GYFWY YYQPPPHVMI STTEWAAAAP DFFVKKTRRR PGGGGGGAAA A--------- -----GYFWY YYQPPPHVMI STTEWAAAAP DFFVKKTRRR PGGGGGGAAA A--------- -----GYFWY YYQPPPHVMI STTEWAAAAP DFFVKKTRRR PGGGGGGAAA A--------- -----GYFWY YYQPPPHVMI STTEWAAAAP DFFVKKTRRR PGGGGGGAAA A--------- -----GYFWY YYQPPPHVMI STTEWAAAAP ---------- ---------- ---------- ---------- ---------- ---------- LLLCSS---- ---------- ---------- ---------- ---------- -AAISAAAHS LFFVKKRNNN RLFFFFFIII I--------- -----ERHLY YYENNNWLFW SWWIQCCCCS DFFVKKNAAA EGEEEEEAAA A--------- -----GYFWY YYQPPPHVMI STTEWGGGAP DFFVKKNVVV EGEEEEEAAA A--------- -----GYFWY YYQPPPHVMI STTEWGGGAP LFFVKKRKKK PGHHHHHPPP P--------- -----GYFWY YYQPPPHTMI STTSWGGGAP LFFVKKRKKK PGHHHHHPPP P--------- -----GYFWY YYQPPPHTMI STTSWGGGAP LFFIKKRKKK PGHHHHHPPP P--------- -----GYFWY YYQPPPHTMI STTSWGGGAP LFFIKKRKKK PDIIIIIPPP P--------- -----GYFWY YYQPPPHTMI STTSWGGGAP LFFVKKRKKK PGHHHHHPPP P--------- -----GYYWY YYQPPPHTMI SSSSWGGGAP DFFPKKTAAA DEKKKKKVVV V--------- -----NYFWY YYQPPPRVMI STTEWGGGSP DFFPKKTAAA DGKKKKKVVV V--------- -----NYFWY YYQPPPRIMI STTEWGGGSP ---------- ---------- ---------- ---------- ---------- SIILRGGGGP FFFLVVTRRR GDRRRRRAAA A--------- -----GYYWY YYQPPPFVMV ASSEWGGGAP FFFCIITKKK GDKKKKKAAA A--------- -----GYFWY YYQPPPFVMV SSSEWGGGAP SNNLSSKAAA SQFFFFFEEE E--------- -----QLNHN NNNGGGRKSE SDDRPDDDEP NEEVAAYPPP TADDDDDMMM MVVVVVAAAV VVADDGYIRA AALIIIKVML TSSSFTTTGW TEEVAAHPPP TDGGGGGLLL LIIIIIKKKT TTADDDYVRA AALPPPKLLV TSSSFTTTGW PN---TTTIE DDDG---LLL H--RNRIHHF WWDKRRRILL LTTLGGGEEE EMMMLL---- PR---CCCFE EEEG---LLL CGGANKLHHV WWDKRHHLII IDDLGGGQQQ EMMMLL---- PP---QQQFE NNNG---PPP DNNKHRLHHF WWDARNNVII IDDLGGGAAA QMMMLL---- PP---QQQFE NNNG---PPP DNNKHRLHHF WWDARNNVII IDDLGGGAAA NMMMLL---- PP---QQQFE NNNG---PPP DNNKHKIHHF WWKDRNNVII IDDLGGGAAA NMMMLL---- PD---MMMVE DDDG---PPP IAARRRLHHF WWDRRHHLII IDDFGGGDDD ELLLFF---- PR---MMMVE SSSG---GGG EGGKHRLHHV WWDRRHHLLL LDDLGGGAAA EMMMLL---- PN---MMMIE GGGG---PPP IKKGRRLHHI WWDRRHHLLL LDDVGGGEEE EMMMLL---- PN---VVVFK DDDGFFFAAA VGGLSRIFFV WWDRHIIILL LQQMTTT--- -LLLPP---- PN---VVVFK DDDGFFFAAA VGGLSHIHHV WWDRHIIILL LQQMKKK--- -LLLPP---- PN---VVVFR DDDGFFFAAA VGGLSHLHHV WWDRHIIILL LTTLQQQ--- -LLLPP---- PN---VVVLR DDDGFFFAAA VGGLSHLYYV WWDRRIIVLL LPPLQQQ--- -LLLPP---- PN---VVVLR DDDGFFFAAA VGGLSHLYYV WWDHHIIVLL LSSLKKK--- -LLLPP---- PN---VVVLR DDDGFFFAAA VGGLSHLYYV WWDRHIIVLL LSSLKKK--- -LLLPP---- PN---VVVLR DDDGFFFAAA VGGLSHLYYV WWDRHIIVLL LSSLKKK--- -LLLPP---- PN---VVVLR DDDGFFFAAA VGGLSHLYYV WWDRHIIVLL LSSLKKK--- -LLLPP---- PN---VVVVQ NNNGFFFAAA VGGLKHLHHV WWDRHIIVLL LLLMPPP--- -HHHPP---- ---------- ---------- ---------- ---------- ---------- ---------- SN---LLLRL TTTGSSSYYY ASSRGIT--- ---------- ---------- ---------- SL---FFFYT TTTGAAAMMM LSSGVISCCL DDNMRIIDLL LPPLQQQ--- -AAAAANNPP PK---AAAFA LLLGFFFEEE VGGMHSLNNV WWDEHRRIII IDDLGGGEEE -LLLPP---- PK---AAAFA LLLGFFFEEE VGGHHSLNNV WWDEHLLVII IDDLGGGKKK -LLLPP---- PT---AAAFT KKKGFFFQQQ VGGLRHLTTC IIQRGLLRLL LDDLGGGNNN -LLLPP---- PK---AAAFL QQQGFFFQQQ VGGLRHLHHV YYSGGIIKLL LDDLGGGDDD -LLLPP---- PK---AAAFS KKKGFFFQQQ VGGLSHLHHV YYSGGMMKII IDDLGGGEEE -LLLPP---- PK---AAAFS KKKGFFFQQQ VGGLSHLHHV YYSGGIIKII IDDLGGGPPP -LLLPP---- PA---AAAFR TTTGFFFQQQ VGGLRHLHHV YYDGGLLKLL LDDLGGGSSS -LLLPP---- PN---HHHIK KKKGFFFAAA VGGLNSVHHI FFESKYYLII IDDLPPPQQQ PAAAPP---- PN---HHHIK KKKGFFFAAA VGGLNSVHHI FFETKHHLII IDDLPPPMMM PAAAPP---- PV---TTTVC RRRDEEEKKK QPPLKCKRRV YY-------- ---------- ---------- PK---LLLFR RRRGYYYTTT CTTQCRLNNF YYRERLLFII IDDLGGGDDD -LLLPP---- PN---KKKWR RRRGWWWVVV LSSQCRLNNF YYKTQLLYII IDDLGGGSSS -IIIPP---- PI---MMMAF EEESSSSFFF KPPLQHVAAE VVL------- ---------- ---------- WSNNNMMMMD FFFGQQQQQQ AKKRNTIVVQ WWDTRPPKFF FNNVPPPGGG A--------- WNNNNMMMMD FFFGKKKAAA PKKHNTVVVT WWDTKPPKFF FDDVPPPGGG A--------- EELLPPLPTT TKLMGFFINN MVKDSIIWWW FFYEEEDKKK WAAAEEKVEI IAPPPLLENL EEVVPPLPTT TKLMGFFVNN VVKDSIIWWW FFYEEEDKKK WAAAEERVDI IAPPPFFEPL EEVVPPAPVV VREYGFFVGG VVTNSIIWWW WWREEEGKKK FVVVKKKTTI IAPPPAATEL EEVVPPAPVV VREYGFFVGG VVTNSIIWWW WWREEEGKKK FAAAEEKTTI IPPPPAAPKL EEIIPPAPSS SKDYGFFCGG VVTNAIIWWW WWQDDDDTTT FAAAKKKTTI IPPPPAADDL EELLPPAPTT TKAYGFFVNN CVKDSIIWWW YYRDDDKKKK WVVVRRKVEI IAAAAAADQL EELLPPAPTT TKAYGFFMNN CVKDSIIWWW YYRDDDNSSS WLLLKKKVDI IAPPPAASQL EELLPPAPAA ARTYGFFVGG VVEDSVVWWW HHRQQQNSSS WIIIRRKVEI IAPPPAAEQL EEIIFFLPSS SATQGFFVGG CANIYKKEEE GG-------- --------WS SEVVVIIQSK EEIIFFLPDD DATQGFFVGG CANIYKKGGG GG-------- --------WS SEVVVIIQSK EEIIFFLPDD DAAQGFFVGG CATIYKKGGG GG-------- --------WS SEVVVIIQPK EEIIFFLPDD DAAQGFFVGG CATIFKKDDD GG-------- --------WS SQVVVIIQPK EEIIFFLPDD DAAQGFFVGG CATIYKKGGG GG-------- --------WS SEVVVIIQPK EEIIFFLPDD DAAQGFFVGG CATIYKKGGG GG-------- --------WS SEVVVIIQPK EEIIFFLPDD DAAQGFFVGG CATIYKKGGG GG-------- --------WS SEVVVIIQPK EEIIFFLPDD DAAQGFFVGG CATIYKKGGG GG-------- --------WS SEVVVIIQPK EEIIFFLPAA AASQGFFVGG CATIYKKGGG GG-------- --------WS SEVVVIIEPK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CCLLSSIKNN NINQDYYDVV VESGSDDAAA YY-------- --------VV VKKKKLLDYA EEIIFFLPDD DAAQGLLVGG CATVYKKDDD GG-------- --------WA AEVVVIIKSK EEIIFFLPDD DADQGLLVGG CASIYKKDDD GG-------- --------WA AEVVVIIQSK EEIIFFLPAA AKDTGFFVGG SANMFKKDDD GG-------- --------WS SEAAAIIPPL EEIIFFLPAA AKDTGFFVGG SANMFKKDDD GG-------- --------WN NEVVVIISPL EEIIFFLPSS SKDTGYYVGG SANMFKKDDD DD-------- --------WS SEVVVIISPL EEIIFFLPSS SKDTGFFVGG SANMFKKDDD EE-------- --------WS SEVVVIISPL EEVVFFLPSS SKDTGYYVGG CANMFKKDDD GG-------- --------WS SEAAAIISPL EEVVFFLPTT TSEHAFFVGG CAGIHPPEEE NNS------- ------T-HA ATVVVAAFSK EEVVFFLPTT TSEHAFFVGG CAAIHPPKKK NNP------- ------K-QT TSVVVAATSK ---------- ---------- ---------- ---------- ---------- ---------- EEIIFFLPRR RENQGYYVGG CAXXX----- ---------- ---------- ---------- EEIIFFLPKK KKAEGFFVGG CAKVKKKDDD SSD------- ------EFAK KVDDDIIPLV ---------- ---------- ---------- ---------- ---------- ---------- EEIIFFPSNN NANYAFFSTT TAQLYEEAAA GG-------- ---------- -------EAK EEIICCAEAA AHNYCFFTSS TAQLYEEEEE GG-------- ---------- -------EAK ILLLKPFKKA PVVDIIIDDS LDDDKKYSSL GRQYDSNNNN KKPPVVVTTG GGHHHAAHHH VLLLKDFKKM PVVDIIIDDS LDDDRRYSSL GRQYDTNNNN QQPPRRRAAG GGHHHEEHHH LLLLQGFGGA PVVDIIIDDS LDDDRRYSSC GRQYDSDDDD NNPPVVVAAG GGRRRAAHHH LLLLQGFGGA PVVDIIIDDS MDDDRRYSSC GRQYDSDDDD KKPPKKKAAG GGRRRTTHHH LLLLKGFGGA PVVDIIIDDS LDDDKKYAAC GHQYDSDDDD NNPPVVVTTG GGKKKTTHHH VLLLKGFKKA PVVDIIIDDS MDDDRRYSSC GLQYDSDDDD EEPPKKKTTG GGSSSAAHHH ILLLKPFKKA PVVDIIINNS VDDDRRYSSC GHQYDSDDDD NNPPRRRTTG GGRRRAAHHH LLLLKDFGGA PVVDIIINNS LDDDRRYSSC GRQYDSDDDD NNPPRRRTTG GGRRRAAHHH KGGGWMLPPE PIIDIIILLS LDDDRRYSSN GRQYDSNNNN KKPPRRRTTG GGVVVGGSSS KGGGWMLPPE PIIDIIILLS LDDDRRYSSN GRQYDSNNNN KKPPRRRTTG GGVVVGGSSS KGGGWMLPPE PIIDIIILLS LDDDRRYSSN GRQYDSDDDD RRPPRRRTTG GGVVVGGPPP KGGGWMLPPE PIIDIIILLS LDDDHHYSSN GRQYDSDDDD RRPPRRRTTG GGVVVDDPPP KGGGWLLPPE PIIDIIILLS LDDDRRYSSN GRQYDSDDDD RRPPRRRTTG GGVVVGGPPP KGGGWLLPPE PIIDIIILLS LDDDRRYSSN GRQYDSDDDD RRPPRRR--- ---------- KGGGWLLPPE PII------- ---------- ---------- ---------- ---------- KGGGWLLPPE PIIDIIILLS LDDDRRYSSN GRQYDSDDDD RRPPRRRTTG GGVVVGGPPP KGGGWMLPPE PIIDIIILLS LDDDRRYNNN GRQYDSDDDD RRPPRRRVVG GGVVVGGPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AKKKFGVVVS SFFPAAAWWF FDDDLLILLS ---------- ---------- ---------- EGGGWALPPE PIIDIIILLS LDDDRRYSSN GRQYDTDDDD NNPPKKKVVG GGLLLGGPPP EGGGWPMPPE PIIDIIILLS LDDDRRYSSN GRQYDTDDDD NNPPKKKVVG GGQQQGGPPP QNNNWILPPE PIIDFFFLLS LDDDRRYVVN GRQYNEDDDD NNPPVVVTTG GGQQQGGPPP QNNNWFLPPE PIIDFFFLLS LDDDRRYVVN GRQYNEDDDD NNPPKKKTTG GGQQQGGPPP ENNNWILPPE PIIDFFFLLS LDDDRRYVVN GRQYNEDDDD NNPPVVVTTG GGQQQGGPPP ENNNWILPPE PIIDFFFLLS LDDDRRYVVN GRQYNEDDDD NNPPVVVTTG GGQQQGGPPP RNNNWILPPE PIIDFFFVVS LDDDRRYVVN GRQYNEDDDD KKPPVVVAAG GGQQQGGEEE SGGGWALPPE PIIDIIILLS MDDDRRYSSC GRQYDSDDDD KKVVKKKNNS GGHHHEENNN ENNNWALPPD PIIDIIILLS MDDDRRYSSC GRQYDSDDDD NNPPKKKNNS GGHHHEETTT ---------- ---------- ---------- ---------- ---------- ---------- ENNNGEIEEM GMMDIIILLS LDDDRRYSSN GRQYDSDDDD NNPPRRRTTG GGQQQDDPPP GSSSGVAEED GIIDIIIIIS LDDDRRYNNC GRQYDTDDDD NNPPKKKTTG GGCCCDDPPP ---------- ---------- ---------- ---------- ---------- ---------- ADDDIGNPPA IPPDIIISSA ADDDQQWNNS GRLFDSDDDD KKPPFFFIIY DDNNN----- ADDDIGEPPA VPPDIIISSS NDDDSSWNNT GRLFDSDDDD HHPPRRRVVY GGNNN----- ---------- ---------- --GHKKKLLT TTAAPQMERD DGGGRVYSSS WWWDQFFEGG ---------- ---------- --GAEEEAAT TTAAPQMSRD DGGGRVYSSS WWWNQFF-GG ---------- ---------- --GRTTTFFA AAGGPQMERD DGGGRVYSSS WWWDQFFDGG ---------- ---------- --GKAAAFFA AAGGPQMERD DGGGRVYSSS WWWDQFFDGG ---------- ---------- --GKTTTFFG GGGGPQMERD DGGGKVYSSS WWWDQFFGDD GG-------- ---------- AANGAAALLN NNGGPQMERD DGGGRVYSGG VVVDQFFEGG ---------- ---------- AASAEEELLN NNGGPQMERD DGGGRVYSRR WWWDQFFDGG ---------- ---------- --SGPPPLLN NNGGPQMERD DGGGRVYSAA WWWDQFFVGG QQVVVLE-DE TTTTCEEPLL VVGKRRRIIP PPGGPQMQLD DGGGKLYSSS WWWDQFFPDD QQVVVLE-DE TTTTCEEPLL VVGKRRRVVP PPGGPQMQLD DGGGKLYSSS WWWDQFFPNN QQVVVLE-DE KKKKSEEPLL VVGKKKKVVP PPGGPQMQLD DGGGKLYSSS WWWDQFFPDD QQVVVLD-DE DDDDSEEPLL VVGKQQQVVA AAGGPQMQLD DGGGKLYSSS WWWDQFFPDD QQVVVLE-DE KKKKSEEPLL VVGKRRRVVA AAGGPQMQLD DGGGKLYSSS WWWDQFFPDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQVVVLE-DE KKKKSEEPLL VVGKRRRVVA AAGGPQMQLD DGGGKLYSSS WWWDQFFPDD QQVVVLE-DE KKKKSEEPLL VVGKRRRVVP PPGGPQMQLD DGGGKIYSSS WWWDQFFPDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TTVVVLE-DD EEEECDDPVV VVGKKKKVVP PPGGPQMQLD DGGGKLYSSS WWWDQFFPDD TTVVVLE-DE EEEECDDPVV VVGKIIIIIP PPGGPQMQLD DGGGKIYSSS WWWDQFFPDD AAAAAIG-EG TTTTWDDVPP IIGQKKKLLR RRGGPQMQLD DGGGKLYSSS WWWDQFFPGG VVAAAVK-DG TTTTWDDVPP IIGKKKKLLR RRGGPQMQLD DGGGKLYSSS WWWDQFFPKK KKAAAVG-EG SSSSFDDVPP IIGKSSSLLR RRGGPQMQLD DGGGKLYSSS WWWDQFFPEE KKAAAVG-EG TTTTFEEVPP IIGKSSSLLR RRGGPQMQLD DGGGKLYSSS WWWVSFFPEE VVYYYVT-ED EEEEESSVPP VVGHRRRLLR RRGGPQMQLD DGGGKIYSSS WWWDQFFQDD KKVVVLE-GK -----EEALL VVGRKKKIIE EEGGPQMQLD DGGGKLYSKK WWWDQFFPEE KKVVVLE-EH -----PPALL VVGRQQQIIE EEGGPQMQLD DGGGKLYSKK WWWDQFFPEE ---------- ---------- ---------- --GGPAKQVD DGGGKLYSSS WWWDQFFPNN RRVVVLN-DE KKKKEEEPVV LLGRRRRLLL LLGGPQMQLD DGGGRLYSSS WWWDQFFPEE VVIIIVKEDE KKKKEPPARR VVGRRRRLLE EEGGPQMQLD DGGGKLYSSS WWWDQFFPKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MSWD DGGGKVYSAA WWWD------ ---------- ---------- ---------- ------MSWD DGGGQLYSAA WWWD------ GGGWWMVKLL LNNAN----- --GGLDFFFV VVVDDDFE-- ----ARHQQQ VRLLSGDASS GGGWWMAKVV VNNVN----- --GGLEFFFV VVVDDDFR-- ----ARHQQQ VRLLWGDAST AAAAAQVLAA AHHAG----- --GGLAYWWV VVVEEEFDGG ----YRHQQQ IRLLEGDCST GGGVVEVMAA ANNVG----- --GGLDYFFV VVVSSSFDGG ----YRHQQQ IRLLEGDCST AAAAAMVMAA ANNVG----- --GGLDFWWV VVVDDDFAGG ----YRHQQQ IRLLEGDCST GGGWWMVKLL LDDAG----- --GGIDFFFL LLLEEEWKGG ----HRHQQQ VRLLQGDCSS GGGWWMVKVV VDDVN----- --GGMDFFFV VVVDDDFE-- ----QRHQQQ IRLLQGDASS GGGWWIAKAA AEEAD----- --GGLDFFFT TTTEEEVDGG ----LRHQQQ IRLLEGDSSS RRREEGSVMM MLLQVDVVVD DDGGLNFLLV VVVDDDFKEE PGGGALHEEE LRYYPGDCSS RRREEGSVMM MLLQIDVVVD DDGGLNFLLV VVVDDDFKEE PGGGALHEEE LRYYPGDCSS RRREEGSVMM MLLQIDVVVD DDGGLNFLLV VVVDDDFKEE PGGGALHEEE LRYYPGDCSS RRREEGSVMM MLLQIDVVVD DDGGLNFLLV VVVDDDFKEE PGGGALHEEE LRYYPGDCSS RRREEGSVMM MLLQVDVVVD DDGGLNFLLV VVVDDDFKEE PGGGALHEEE LRYYPGDCSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRREEGSVMM MLLQVDVVVD DDGGLNFLLV VVVDDDFKEE PGGGALHEEE LRYYPGDCSS RRREEGSVMM MLLQIDVVVD DDGGLNFLLV VVVDDDFKEE PGGGALHEEE IRYYPGDCTS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKKEEGSVMM MLLQIDVVVD DDGGLNFLLV VVVDDDFKEE PGGGVLHEEE LRYYPGDCSS KKKEEGAVMM MLLQIDVVVD DDGGLNFLLV VVVDDDFKEE PGGGVLHEEE IRYYPGDCTS EEEKKGSHII ILLQIDVVVD DDGGLNFFFV VVVDDDFAEE PGGGALHEEE MRYYPGDCTS EEEQQGSHII ILLQIDVVVD DDGGLNFFFV VVVDDDFAEE PGGGSLHEEE MRYYPGDCTS DDDKKGSHII IIIQIDVVVD DDGGLNFFFV VVVDDDFDEE PGGGALHEEE MRYYPGDCTS EEEKKGSHII IIIQIDGGGD DDGGLNFFFV VVVDDDFDEE PGGGSLHEEE MRYYPGDCTS KKKKKGSHMM MLLQIDVVVD DDGGLNFFFV VVVDDDFAEE PGGGSLHEEE MRYYPGDCTS KKKSSGATMM MVVQVNIIID DDGKMNFLLI IIIDDDFKII EGGGYLHEEE MRYYPGDCTS RRRSSGATMM MLLQIDVVVD DDGHMNFLLI IIIDDDFKVV PGGGYLHEEE MRYYPGDCTS KKKEEGSVMM MLLQIDVVVD DDGGLNFLLV VVVDDDFKEE PGGGCLHDDD IRFFPCDSTS AAAAAGGTII IVVQLDIIID DDGGMNFLLV VVVDDDFGEE PGGGGLHEEE MR-------- SSSQQGGHII IVVLIDVVVD DDGGINFLLV VVVDDDFNEE PGGGSLHEEE MRYYPGDCTS ---------- ---------- ---------- ---------- ---------- ---------- KKKKKGKDDD DAAQYLKKKA AADGKVFAAV VVVDDDFELL GGGG-RHIII MRFFGSALYS KKKKKGKDDD DEEQFLKKKL LLDGKKFAAI IIIDDDFAEE KGGG-RHQQQ MRFFGAALYA DDSY--- DDSY--- DDSYSS- DDSYSS- DDSYSS- DDSY--- DDSF--- DDSYSS- DDI---- DDI---- DDI---- DDI---- DDI---- ------- ------- DDI---- DDI---- ------- ------- ------- DDI---- DDI---- DDI---- DDI---- DDI---- DDI---- DDI---- DDI---- DDI---- DDI---- ------- DDIADD- ------- SS----- GGPDNNQ 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNAAKAAKKK KKKQPPEACR TAAPGGLTAA AARLLLAADD AMMMQSRRQL LLLLLLLLTP gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GPVVRAEEET TSSIIQQQVV VVAASSSSSP PPEESKKGRT RSVVLVVSAA AQVQQAAAAQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------GGGP PLLLLNNNNN NNTTPPPTTP PPNNPLLAPS PPHHVPPRPP PRIPPPRRRP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMAP PPTFFYSSSK KAAAPEDYAA ACLYTGTGGN ---------- ---------- ---------K KPTFFYTTTR RAAAPEDYAA AALYVGTGGN ---------- ---------- ---------S SPTFFHSSSE EAAAAEEYLL LLLSPDFSS- ---------- ---------- ---------T TPTFFHSSSK KAAAAENYLL LLLSPDFSS- ---------- ---------- ---------T TPTFFYSSSK KAGGVEKFLL LMLSPDASS- ---------- ---------- ---------T TPSFFYSSSR RAAAPETYAA AMFDPERKK- ---------- ---------- ---------T TPTFFYSSSR RAAAAEKYVV VRLNPMANN- ---------- ---------- ---------S SPTFFYSSSK KAAARERYAA ALLDPGREE- ---------- ---------- -----ATTKK KPGYYPPPPE EMGGREEYPP PCIYRNTGGE ---------- ---------- ---------- ---------- --GGREEYPP PCIYRNTGGE QQWLPPKGAA VIAPPPARGL LLL-ASTTQK KPGYYPPPPE EMGGREEYPP PCIYGNTGGE ---------- ---------- ---------- ---------- -MGGREEYPP PCIYRNTGGE ---------- ---------- -----ATTKN NPGYYSPPPE EMGGREEYPP PCIYRNTGGE ----EEAGAF TQSVVVAQPM RRRASATTKN NPGYYSPPPE EMGGREEYPP PCIYRNTGGE ---------- ---------- -----ATTKN NPGYYSPPPE EMGG------ ---------E ---------- ---------- -----ATTKN NPGYYSPPPE EMGGREEYPP PCIYRNTGGE --GLKKEGHT APWFFFLSGQ LLLEDATTKD DPGYYPPPPE EMGGREEYPP PCIYRNTGGE --NSGGLFDQ TTELLLHTYC TTTFTPTTKN NPGYYSPPPE EMGGREEYPP PCIYRNTGGE ---------- ---------- -----ATTKN NPGYYSPPPE EMGGREEYPP PCIYRNTGGE PPHAHHLLQH IEGAAAAAVE TTTAAGKKTH HPGYYAPPPE EMGGREKYTT TCVYNGTGGN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MAAKS SPGYYKPPPD DMGGREEYPP PCIYRSTGGN ---------- -ATVVVLDHG VVVEKS--VC CPGYYAPPPE EMGGRESYTT TAVYAGTGGE ---------- -GTVVVLQHA VVVEKNNNQC CPGYYAPPPE EMGGRETYTT TAVYAGTGGE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------L LPGYYAPPPA AMGGSEKYTT TAVYTGTGGD ---------- ---------- MMMAAGAAAG GPGYYAPPPE EMGGREKYTT TCVYNGTGGN ---------- ---------- ---PNGLLKG GPGYYAPPPD DIGGREEFTT TAP---NAAD ---------- ---------- -----PLLKG GPGYYAPPPD DIGGREEFTT TAP---HAAD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMSK KPGYYAPPPD DVGGVEKYVV VCVQPNLDDE ---------- ---------- ---------- ---------- -MGGREKYVV VTVQPNLDDP ---------- ---------- ---------- -PGLLI---D DLLLDRFFNN NWLHGDIRRY ---MRREG-- --------AL AAA-AAMMGF FDETTCSSSY YPTTQEEYWW WTLGVEGMMD ---MRRISGP SHFAAALRAL VVVLAALLAA ADETTCSSSY YKTTQEDYWW WTLGAEGVVD NRADDDDDFF VDDNNPTSSS IVVVHHKVLY YNNDDEEHWN SSALLLLCCC -GGG--NNNN NAPDDDDDFF VDDDDPTGGG VIIIYYKLLY YGGDDEEHWN SSAYYYYCCC -AAA--FFFF -RPDDDDDAA VDDKKPTGGG IVVVHHTVMN NGGDDEEHWN SSSLLLLSSS -TTTGGFFFF -KPDDDDDAA VDDKKPTGGG IVVVHHTVMN NGGDDEEHWN SSALLLLSSS -AAAGGFFFF -KPDDDDDGG VDDDDPKGGG IVVVHHQLMN NGGDDEEHWN SSALLLLSSS -TTTGGFFFF -QPDDDDDAA VDDDDPRAAA IVVVGGQVMH HGGDDEEHWN SSCLLLLCCC -AAAPPHHHH -KPDDDDDAA VDDDDSTGGG VVVVGGVTMY YGGGGEEHWN SSMLLLLCCC -AAAPPHHHH -RPDDDDDAA VDDDDPTAAA IVVVGGRVMN NAADDEEHWN SAALLLLCCC -AAAPPHHHH EAPDDDDDYY TDDDDPQSSS VIIIHHRLMY YKKDDEEHWN SSC------- -FFFGGTTTT EAPDDDDDYY TDDDDPHSSS VIIIHHRLMH HKKDDEEHWN SSC------- -FFFGGTTTT EAPDDDDDYY TDDDDPQCCC VIIIHHRLMN NRRDDEEHWN SSC------- -FFFGGTTTT EAPDDDDDYY TDDDDPQCCC VIIIHHRLMH HKKDDEEHWN SSC------- -YYYGGTTTT EAPDDDDDYY TDDDDPQCCC VIIIHHRLMN NKKDDEEHWN SSC------- -FFFGGTTTT EAPDDDDDYY TDDDDPQCCC VIIIEE---- ---------- ---------- ---------- EAPDDDDDYY TDDDDPQCCC VIIIHHRLMN NKKDDEEHWN SSC------- -FFFGGTTTT EAPDDDDDYY TDDDDPQCCC VIIIHHRLMN NKKDDEEHWN SSC------- -FFFGGTTTT EAPDDDDDYY TDDDDPQSSS VIIIHHRLMY YKKDDEEHWN SSC------- -FFFGGTTTT EAPDDDDDYY TDDDDPQCCC VIIIHHRLMN NKKDDEEHWN SSC------- -FFFGGTTTT EAPDDDDDYY TDDDDPQCCC VIIIHHRLMN NKKDDEEHWN SSC------- -FFFGGTTTT NKLDDDDDYY TDDDDPTSSS VIIIHHRLVH HGGDDKKHWN SSC------- -HHHGGSSSS ---------- ---------- --------MN NNNDDEEHWN SSC------- -YYYGGSSSS NKPDDDDDYY TDDDDPSSSS VIIIHHRLMN NNNDDEEHWN SSC------- -YYYGGSSSS EKPDDDDDYY TDDDDPTSSS VIIIHHRLVY YGGDDEEHWN SSC------- -HHHGGSSSS EKPDDDDDYY TDDDDPTSSS VIIIHHRLVY YGGDDEEHWN SSC------- -HHHGGSSSS ---------- ---------- --------MF FGGDDEEHWN SSC------- -HHHGGSSSS DKPDDDDDYY TDDDDPSSSS VIIIHHRLMF FGGDDEEHWN SSC------- -HHHGGSSSS NKPDDDDDYY TDDDDPTSSS VIIIHHRLVH HGGDDEEHWN SSC------- -HHHGGSSSS DGPDDDDDAA TDDNNPTCCC VIIISSRVVH HGGDDEEHWN SSC------- -HHHDDTTTT DGPDDDDDAA TNNNNPTCCC IIIISSRVVN NGGDDEEHWN SSC------- -HHHDDTTTT ---------- ---------- ---------- ---------- ---------- ---------- EHGDDDDDYY TDDDDPTCCC VIIIHHRTTS SHHNNEEHWN SSCHHHHFFF VGGGGGVVVV PHGDDDDDYY TDDDDPTCCC IVVVHHRTTR RGGDDEEHWN SSCYYYYYYY VSSSSSVVVV YDITTTTTDD NRRVVGLGGG VLLLKKDGVV VEEDDKKDPT ILK------- ----GGVVVV DEQDDDDDKK TDDRRPTGGG VIIINNSVVG GRRNNEEHFS ---------- ---------- DEQDDDDDKK TDDNNPQGGG VVVVNNTLVG GRRNNEEHFT ---------- ---------- RLLLIGLRSS RYYYNNPREE EPKKKIKIPP EEEVVVKKSS SSSSSRHGII IYISSAALGN RLLLIALRSS RYYYDDKRRR RPAAAVKVPP EVVAAAVVTT TTTTTKHGII IYISSAALGG RLLLIGLRSS RYYYHHPTQQ QARRRIKIPP DEEIIILLTT TTSSSRHGII IYVSSTTLGG RLLLIGLRSS RYYYDDPTKK KAKKKIKIPP EEEVVVFFTT TTSSSRHGII IYVSSTTLGG RLLLIGIRSS RYYYEEPLKK KAKKKIKIPP EEEVVVFFTT TTSSSRHGII IYVSSTTLGG RLLLVGLRSS RYYYDDPLKK KPFFFLKIPP ETTLLLAATT TTSSSRHGII IYVTTAALGN RLLLVDIRSS HTTTDDPTQQ QPKKKVKIPP NEELLLAATT TTAAARHGII IYISSAALGS RLLLIGIRSS RHHHDDPREE EPRRRIKIPP EEELLLHHTT TTSSSRHGVV VYVSSAALGS RLLLIGLMSS RYYYEEPRAA APKKKLKIAA SEEIIIQQCC CCSSSNHLEE EVMVVNNTLG RLLLISIISS RYYYEEPRAA APKKKLKIPP NEEIIIHHCC CCGGGNHLEE EVMIISSSLG RLLLMCLMSS RYYYDDPRAA APKKKLKIAA EDDIIIHHCC CCGGGYHLEE EVMIISSTLG RLLLVALISS RYYYEEPRAA APKKKLKIPP KDDIIIHHCC CCGGGFHLEE EVMVVSSTLG RLLLVSLISS RYYYEEPRAA APKKKLKIPP EDDIIIHHCC CCAAAFHLEE EVMIISSSLG ---------- ---------- --------PP KDDIIIHHCC CCAAAFHLEE EVMIISSSLG RLLLVSLISS RYYYEEPRAA APKKKLKIPP KDDIIIHHCC CCAAAFHLEE EVMIISSSLG RLLLVSLISS RYYYEEPRAA APKKKLKIPP KDDIIIHHCC CCAAAFHLEE EVMIISSSLG RLLLVSFISS RYYYEEPRAA APKKKLKIAA KDDIIIHHCC CCGGGTHLEE EVMIISSTLG RLLLVSL--- ---------- ---------- ---------- ---------- ---------- RLLLVSLISS RYYYEEPRAA APKKKLKIPP KDDIIIHHCC CCAAAFHLEE EVMIISSSLG RLLLISLLSS RYYYDDPRTT TPSSSLKVSS EDDIIIAAII IIGGGFHLDD DIMIISSCLG RLLLICLISS RYYYDDPRAA APRRRIKVPP YEEVVVFFCC CCAAANHLEE EIMIISSSIG RLLLICLISS RYYYDDPRAA APRRRIKVPP YEEVVVFFCC CCAAANHLEE EIMIISSSLG RLLLISLVSS RYYYNNPRSS SPSSSLKVPP ADDIIIIITT TTAAAYHLEE ELMIISSCLG RLLLIGIVSS RYYYNNPRAA APSSSLKVPP EDDIIISSTT TTAAAYHLEE EIMIISSCIG RLLLVSLISS RYYYNNPRAA APSSSLKVPP KEEIIIAATT TTAAAYHLEE EILVVSSCLG RLLLVSLISS RYYYNNPRAA APSSSLKVPP KEEIIIAATT TTAAAFHREE EILVVSSCLG RLLLISLLSS RYYYDDPRAA APAAALKVAA EDDIIIAATT TTGGGFHLEE EIMIISSCLG RLLLICLNSS RYYYEE-RKK KIYYYLHIPP SKKLLLHHNN NNSSSFHLNN NIMIISSTLG RLLLICLNSS RYYYEE-REE EIYYYLHIPP SKKLLLHHNN NNSSSFHLNN NIMIISSTLG -MMMVKLSSS VGGG------ ---------- ---------- ---------- ---------- RLLLVCLNSS RFFFDDPRAA APKKKLKIGG -DDVVVLLAA AATTTAHLNN NIMIISSIMG RLLLVSLNSS FYYYDDPRKK KPEEEIKIGG -DDVVVLLHH HHTTTAHLNN NIMIISSVMG GMMMLSLDGG RYYYSSAWDD DKQQQFP--- -DDLLLIILL LLAAAIHQAA ALKQQDDGVN RFFFWGLDTT RFFFDDPSNN NPKKKLKITT -FFVVVKKGG GGVVVGHLMM MMITTGGLSN RLLLWGLDTT KFFFDDPARR RPVVVLKIDD -FFVVVEEGG GGVVVGHLMM MLITTGGLSN NNN---G-EE GGIILMLDYS EPPLLGGKDR RDY------- ---------L LYFWWWWWWW GGG---GREE GGIIFLLDDT EPPIIGGRYR RPY------- ---------F FYFWWWWWWW GGGGKKGTDD GGIIFIMDET DVVLLGGRDR RPD------- ---------K KYFWWWWWWW GGGGKKGTNN GGVVFIMDET EVVLLGGRDR RPT------- ---------L LYFWWWWWWW GGGGEEGTDD GGIIFILDET EIILLGGRDR RET------- ---------K KYFWWWWWWW NNN---G-KK GGIIAMLDQS EPPLLGGRER RPY------- ---------F FYGWWWWWWW SSS---G-EE GGIIFILDDN EVVLLGGRDR RDY------- ---------L LYFWWWWWWW SSS---G-DD GGVVFVMDES DPPLLGGRER RPQ------- ---------L LYFWWWWWWW GGG---QGNN GSFFVLLDET EVVKKGGTPG GAP------- ---------M MYFWWWYYYY GGG---QGNN GGFFVLLDET EVVKKGGTPG GEP------- ---------M MYFWWWYYYY GGG---KGNN GGFFVLLDET EVVKKGGTPG GAP------- ---------M MYFWWWYYYY GGG---EGNN GGFFVLLDKT EVVKKGGTPG GAP------- ---------L LYFWWWYYYY GGG---KGNN GGFFVLLDET EVVKKGGTPG GAP------- ---------S SYFWWWYYYY GGG---KGNN GGFFVLLDET EVVKKGGTPG GAP------- ---------L LYFWWWYYYY GGG---KGNN GGFFVLLDET EVVKKGGTPG GAP------- ---------L LYFWWWYYYY GGG---KGNN GGFFVLLDET EVVKKGGTPG GAP------- ---------L LYFWWWYYYY GGG---KGNN GGFFVLLDET EVVKKGGTPG GSP------- ---------M MYFWWWYYYY ---------- ---------- ---------- ---------- ---------- ---------- GGG---KGNN GGSSLVLL-R ECCSSGG--- ---------- ---------- ---------- GGG---EGNN ANGGFLLLSE NVVKKGGRRL LPS------- ---------K KRHLLLYYYY GGG---YGNN GGFFVLLDET EVVKKGGNEG GAP------- ---------F FYFWWWYYYY GGG---CGNN GGFFVLLDET EVVKKGGNEG GSQ------- ---------F FYFWWWYYYY GGG---DGNN ANGGFLLLSD NVVKKGGRPG GSL------- ---------F FYFWWWYYYY GGG---DGNN ANGGFLLLSE NVVKKGGRPG GSL------- ---------F FYFWWWYYYY GGG---EGNN ANGGFLLLSD NIIKKNNRPG GSL------- ---------F FYFWWWYYYY GGG---EGNN ANGGLLLLSD NIIKKNNRPD DSL------- ---------Y YYFWWWYYYY GGG---EGNN ANGGFLLLSE NVVKKGGRPG GSL------- ---------F FYYWWWYYYY GGG---NGTT PNFFLLLDKT EPPKKGGTDE ETP------- ---------F FYFWWWYYYY GGG---DGSS PNFFLLLDKT EPPKKGGTDG GVP------- ---------F FYFWWWYYYY ---------- ---------- ---------- ---------- ---------- ---------- GGG---EGNN A-DDFVEFKN ELLVVGGTGD DKL------- ---------C CYYWWWYYYY GGG---EGYY A-DDFILFSD NCCIIGGTGD DKL------- ---------C CYFWWWYYYY NNN---LSVV PNGGIQTSHE GLLSSAAKSQ QEI------- ---------L LLNHHHNNNN NNN---DHGG GALLVEYNDG YVVAATTYTA ADQGAAAAVA AGDDAAAAVY YYIRRRAAAA NNN---DHGG GALLVEYTAG YVVAATTHTD DDRGAAAAIK KG--KKKKYY YYVRRRAAAA WNL--EVVLV SSSSVVVP-T LKKLHLLLLD --RYNRHHHL KRKRIHSNRM MM-------- WNL--GVVMI TTTSVVVP-C FSSLCLLLLE GGAYNKHHHL KRRHLYAHRM MM-------- WNL--DYYMV SSSSLLLP-Q IVVPDLLLLA NNKYHRHHHL ARRNVQTHQM MM-------- WNL--DYYMV TTTSLLLP-Q IVVPDLLLLS NNKYHRHHHL ARRNVQTHQM MM-------- WNL--DYYMV SSSSLLLP-Q IVVPDLLLLS NNKYHKHHHL DRKNVQTHQM MM-------- WHL--DTTLV TTTSTTTP-M LVVPILLLLG AARYRRHHHL RRRHLQEHQL LL-------- WHL--DTTLL TTTSTTTP-M VLLGELLLLA GGKYHRHHHL RRRHLQTYQM MM-------- WHL--DTTMV TTTSTTTP-M LDDPILLLLN KKGYRRHHHL RRRHLQAHQM MM-------- YQP--NVVMV SSSTAAAP-V NPPAVEEEE- GGLYSRFFFW RHEIIQTDGL LL------LL YQP--NIIMV SSSTAAAP-V NPPAVEEEE- GGLYSHHHHW RHEIIQTDGL LL------LL YQP--NVVMI SSSTAAAP-V NPPAVEEEE- GGLYSHHHHW RHEIIQTDGL LL------LL YQP--NVVMI SSSTAAAP-V NPPAVKKKK- GGLYSHYYYW RREIVQTDGL LL------LL YQP--NVVMI SSSTAAAP-V NPPAVEEEE- GGLYSHYYYW HHEIVQTDGL LL------LL YQP--NVVMI SSSTAAAP-V NPPAVEEEE- GGLYSHYYYW RHEIVQTDGL LL------LL YQP--NVVMI SSSTAAAP-V NPPAVEEEE- GGLYSHYYYW RHEIVQTDGL LL------LL YQP--NVVMI SSSTAAAP-V NPPAVEEEE- GGLYSHYYYW RHEIVQTDGL LL------LL YQP--NVVMI SSSTAAAP-V NPPAVEEEE- GGLYKHHHHW RHEIVQTDGH HH------LL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---AHHHS-L RDDYASSSS- SSRVGI---- ---------- ---------- YENYYGLLFW SSSWCCCS-F ELLMLTTTT- SSGVVICCCY MRVIDESDQA AANNNPPILL YQP--NVVMI SSSTAAAP-A KMMEVQQQQ- GGMYHSNNNW EHRRIQTDGL LL------LL YQP--NVVMI SSSTAAAP-A KMMEVQQQQ- GGHYHSNNNW EHRLVQTDGL LL------LL YQP--NTTMI SSSTAAAP-A DLLQVAAAA- GGLYRHTTTL RGELRQTTGL LL------LL YQP--NTTMI SSSTAAAP-A NLLQVAAAA- GGLYRHHHHW GGEIKQTKGL LL------LL YQP--KTTMI SSSTAAAP-A DLLQVAAAA- GGLYSHHHHW GGEMKQLTGL LL------LL YQP--KTTMI SSSTAAAP-A NLLQVAAAA- GGLYSHHHHW GGEIKQLTGL LL------LL YQP--KTTMI SSSSAAAP-A DLLQVQQQQ- GGLYRHHHHW GGELKQTTGL LL------LL YQP--NVVMI SSSTSSSP-H NPPAVGGGG- GGLYNSHHHW SKKYLQTLGA AA------LL YQP--NIIMI SSSTSSSP-H NPPAVPPPP- GGLYNSHHHW TKKHLQTRGA AA------LL ---------- SSSIGGGP-T ELLKQPPPP- PPLVKCRRR- ---------- ---------- YQP--NVVMV AAASAAAP-L HPPTCDDDDR TTQYCRNNNW ERELFQTDGL LL------LL YQP--DVVMV SSSSAAAP-K KNNVLEEEEM SSQYCRNNNW TQTLYQTDGI II------LL NNG--EKKSE SSSDEEEP-M ESSFKKKKKG PPLKQHAAA- ---------- ---------- ALI--NVVML TTTSGGGWYM MLLQAEEEEM KKRFNTVVVL TRQPKKVP-- --------LL ALP--NLLLV TTTSGGGWYM MLLAPEEEEM KKHFNTVVVL TKQPKKVP-- --------LL -EEEERLHDP TKLMFFIVVV LLKDSSSSIL LWWFFY-NNN AKEEIIIPPP AAAEELGNNP -EEEERLHDP TKLMFFVVVV TTKDSSSSIL LWWFFY-QQQ ARDDIIIEEE AAAQQFGPPP -EEEERAHDP VREYFFVVVV TTTNSSSSIT TWWWWR-HHH VKTTIIIPPP AAAEEAAEEP -EEEERAHDP VREYFFVVVV TTTNSSSSIT TWWWWR-HHH AKTTIIIPPP PPPEEAKKKP -EEEERAHDP SKDYFFCVVV TTTNAAAAIT TWWWWQKEEE AKTTIIIDDD PPPVVAADDP -EEEERAHDP TKAYFFVVVV LLKDSSSSIT TWWYYR-AAA VKEEIIIPPP AAAEEAPQQP -EEEERAHDP TKAYFFMVVV LLKDSSSSIL LWWYYR-HHH LKDDIIIPPP AAAEEAEQQP -EEEERAHDP ARTYFFVVVV LLEDSSSSVL LWWHHR-GGG IKEEIIIPPP AAAEEAPQQP LEEEERLHDP SATQFFVAAA SSNIYYYYKE EEEGG----- --WWSSSVVV EEEKKIVSSK LEEEERLHDP DATQFFVAAA SSNIYYYYKE EGGGG----- --WWSSSVVV EEEKKIVSSK LEEEERLHNP DAAQFFVAAA SSTIYYYYKQ QGGGG----- --WWSSSVVV EEEKKIVPPK LEEEERLHNP DAAQFFVAAA SSTIFFFFKE EDDGG----- --WWSSSAAA QQQKKIVPPK LEEEERLHNP DAAQFFVAAA SSTIYYYYKE EGGGG----- --WWSSSVVV EEEKKIVPPK LEEEERLHNP DAAQFFVAAA SSTIYYYYKE EGGGG----- --WWSSSVVV EEEKKIVPPK LEEEERLHNP DAAQFFVAAA SSTIYYYYKE EGGGG----- --WWSSSVVV EEEKKIVPPK LEEEERLHNP DAAQFFVAAA SSTIYYYYKE EGGGG----- --WWSSSVVV EEEKKIVPPK LEEEERLHDP AASQFFVAAA SSTIYYYYKE EGGGG----- --WWSSSVVV EEEKKIVPPK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LCCCCRIHWK NINQYYDEEE FFSGSSSSDD DAAYY----- --VVVVVLLL KKKRRLLYYV LEEEERLHDP DAAQLLVAAA SSTVYYYYKK KDDGG----- --WWAAAAAA EEEKKIVSSK LEEEERLHNP DADQLLVAAA SSSIYYYYKK KDDGG----- --WWAAAAAA EEEKKIVSSK LEEEERLHDP AKDTFFVAAA SSNMFFFFKQ QDDGG----- --WWSSSHHH EEELLIVPPK LEEEERLHDP AKDTFFVAAA SSNMFFFFKQ QDDGG----- --WWNNNHHH EEEIIIVPPK LEEEERLHDP SKDTYYVAAA SSNMFFFFKS SDDDD----- --WWSSSYYY EEEIIIVPPK LEEEERLHDP SKDTFFVAAA SSNMFFFFKS SDDEE----- --WWSSSHHH EEEVVIVPPK LEEEERLHDP SKDTYYVAAA SSNMFFFFKA ADDGG----- --WWSSSHHH EEEVVIIPPK LEEEERLHEP TSEHFFVAAA SSGIHHHHPE EEENNS---- -THHAAAAAA TTTLLAISSK LEEEERLHEP TSEHFFVAAA SSAIHHHHPE EKKNNP---- -KQQTTTAAA SSSLLAISSK ---------- ---------- ---------- ---------- ---------- ---------- LEEEERLHNP RENQYYVAAA XXXXXXXX-- ---------- ---------- ---------Q LEEEERLHNP KKAEFFVAAA AAKVKKKKKS SDDSSD---- -EAAKKKKKK VVVIIIGLLD ---------- ---------- ---------- ---------- ---------- ---------- LEEEERPWGS NANYFFSAAA SSQLYYYYED DAAGG----- ---------- ------WAAA LEEEERAWGE AHNYFFTAAA SSQLYYYYEG GEEGG----- ---------- ------WAAA IIKFFFAVPP PPLLLVVVDD IIISFFFLLY SSSLWGGQYY DIISSPKKPV VGKVKGGGII VVKFFFMVPP PPLLLVVVDD IIISFFFLLY SSSLWGGQYY DIITTPQQPR RGRVKGGGLL LLQFFFAVPP PPLLLVVVDD LLLSFFFLLY SSSCWGGQYY DVVSSPNNPV VGSVRGGGII LLQFFFAVPP PPLLLVVVDD LLLSFFFLLY SSSCWGGQYY DVVSSPKKPK KGSVHGGGII LLKFFFACPP PPLLLVVVDD LLLSYYYLLY AAACWGGQYY DVVSSPNNPV VGKVEGGGII VVKFFFAVPP PPLLLVVVDD LLLSFFFLLY SSSCWGGQYY DVVSSPEEPK KGKVRGGGII IIKFFFAVPP PPLLLVVVDD LLLSFFFLLY SSSCWGGQYY DVVSSPNNPR RGKVQGGGII LLKFFFAVPP PPLLLVVVDD LLLSFFFLLY SSSCWGGQYY DVVSSPNNPR RGSVRGGGII KKWLLLEMPP GGLLLIIIDD LLLSFFFLLY SSSNWLGQYY DIISSPKKPR RGQIFGGGSS KKWLLLEMPP GGLLLIIIDD LLLSFFFLLY SSSNWLGQYY DIISSPKKPR RGQIFGGGSS KKWLLLEMPP GGLLLIIIDD LLLSFFFLLY SSSNWLGQYY DIISSPRRPR RGQLFGGGSS KKWLLLEMPP GGLLLIIIDD LLLSFFFLLY SSSNWLGQYY DVVSSPRRPR RGQLFGGGSS KKWLLLEMPP GGLLLIIIDD LLLSFFFLLY SSSNWLGQYY DIISSPRRPR RGQLFGGGSS KKWLLLEMPP GGLLLIIIDD LLLSFFFLLY SSSNWLGQYY DIISSPRRPR R--------- KKWLLLEMPP GGLLLIII-- ---------- ---------- ---------- ---------- KKWLLLEMPP GGLLLIIIDD LLLSFFFLLY SSSNWLGQYY DIISSPRRPR RGQLFGGGSS KKWLLLEMPP GGLLLIIIDD LLLSFFFLLY NNNNWLGQYY DIISSPRRPR RGQIFGGGSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAFVVVSLSS NNEEEFFFPP IIIFLLLIII LLLS------ ---------- ---------- EEWLLLEMPP GGLLLIIIDD IIISFFFLLY SSSNWLGQYY DIITTPNNPK KGQIFGGGSS EEWMMMEMPP GGLLLIIIDD IIISFFFLLY SSSNWLGQYY DIITTTNNPK KGQIFGGGSS QQWLLLEMPP GGLLLIIIDD IIISFFFLLY VVVNWLGQYY NIIEELNNPV VGQLWGGGLL QQWLLLEMPP GGLLLIIIDD IIISFFFLLY VVVNWLGQYY NIIEEVNNPK KGQVWGGGLL EEWLLLEMPP GGLLLIIIDD IIISFFFLLY VVVNWLGQYY NIIEEPNNPV VGQIWGGGLL EEWLLLEMPP GGLLLIIIDD IIISFFFIIY VVVNWLGQYY NIIEEPNNPV VGQIWGGGLL RRWLLLEMPP GGLLLIIIDD IIISYYYLLY VVVNWLGQYY NIIEEPKKPV VGQVWGGGLL SSWLLLEMPP AALLLIIIDD IIISFFFLLY SSSCWLGQYY DIISSPKKVK KSQVYGGGSS EEWLLLDMPP AALLLIIIDD IIISFFFLLY SSSCWLGQYY DIISSPNNPK KSQVFGGGSS ---------- ---------- ---------- ---------- ---------- ---------- EEGIIIMMGG GGMMMMMMDD IIISYYYLLY SSSNWRGQYY DIISSRNNPR RGQVFGGGAA GGGAAADMGG GGMMMIIIDD IIISFFFLLY NNNCWRGQYY DIITTPNNPK KGQLFGGGAA ---------- ---------- ---------- ---------- ---------- ---------- AAINNNADII PPLLLPPPDD IIIATTTLLW NNNSFMGLFF DIISSPKKPF FYEKVDDDQQ AAIEEEAKVV PPLLLPPPDD IIISRRRLLW NNNTFMGLFF DIISSPHHPR RYEKTGGGQQ HRRDDDHPP- ---------- ------GGHH LGAPQQMMLS SSRRRDDRRR RRRYYYNSLS HRRPPPHPP- ---------- ------GGAA AGAPQQMMIS SSRRRDDRRR RRRYYYNSLS RRRPPPHPP- ---------- ------GGRR FGGPQQMMVS SSRRRDDRRR RRRYYYNSLS RRRPPPHPP- ---------- ------GGKK FAGPQQMMVS SSRRRDDRRR RRRYYYNSLS KKKPPPHPP- ---------- ------GGKK FYGPQQMMVS SSRRRDDKKR RRRYYYNSLS SRRTTTHPPG G--------- -----ANNGG LGGPQQMMVS SSRRRDDRRR RRRYYYNSLG RRRGGGHPP- ---------- -----ASSAA LGGPQQMMVS SSRRRDDRRR RRRYYYNSLR RKKAAAHPP- ---------- ------SSGG LGGPQQMMVS SSRRRDDRRR RRRYYYNSLA VRRGGGSVVQ QVV---DETP PLLVVVGGKK IGGPQQMMIS SSLLLDDKKR RRRYYYTSLS VKKGGGSVVQ QVV---DETP PLLVVVGGKK VGGPQQMMIS SSLLLDDKKR RRRYYYTSLS VKKGGGPVVQ QVV---DEKP PLLVVVGGKK VGGPQQMMIS SSLLLDDKKR RRRYYYTSLS VKKGGGPVVQ QVV---DEDP PLLVVVGGKK VGGPQQMMIS SSLLLDDKKR RRRYYYTSLS VKKGGGPVVQ QVV---DEKP PLLVVVGGKK VGGPQQMMIS SSLLLDDKKR RRRYYYTSLS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VKKGGGPVVQ QVV---DEKP PLLVVVGGKK VGGPQQMMIS SSLLLDDKKR RRRYYYTSLS VKKGGGPVVQ QVV---DEKP PLLVVVGGKK VGGPQQMMIS SSLLLDDKKR RRRYYYTSLS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LRRGGGPVVT TVV---DDEP PVVIIVGGKK VGGPQQMMIS SSLLLDDKKR RRRYYYNSLS QRRGGGPVVT TVV---DEEP PVVTTVGGKK IGGPQQMMIS SSLLLDDKKR RRRYYYSSLS QKKSSSPVVA AAA---EGTS VPPEEIGGQQ LGGPQQMMIT TTLLLDDKKR RRRYYYNSLS QKKSSSPVVV VAA---DGTS VPPEEIGGKK LGGPQQMMIS SSLLLDDKKR RRRYYYNSLS QKKSSSPVVK KAA---EGSF VPPQQIGGKK LGGPQQMMIS SSLLLDDKKR RRRYYYNSLS QKKSSSPVVK KAA---EGTF VPPQQIGGKK LGGPQQMMIS SSLLLDDKKR RRRYYYNSLS QKKSSSEVVV VYY---EDEY VPPQQVGGHH LGGPQQMMIS SSLLLDDKKR RRRYYYNSLS HTTSSSNVVK KVV---GK-I ALLYYVGGRR IGGPQQMMLS SSLLLDDKKR RRRYYYTSLK HSSTTTTVVK KVV---EH-I ALLYYVGGRR IGGPQQMMLS SSLLLDDKKR RRRYYYTSLK ---------- ---------- ---------- -GGPAAKKIS SSVVVDDKKR RRRYYYNSFS QRRAAAPRRR RVV---DEKP PVVFFLGGRR LGGPQQMMLS SSLLLDDRRR RRRYYYSSLS CSSLLLPNNV VIIEEEDEKP ARRYYVGGRR LGGPQQMMLS SSLLLDDKKR RRRYYYSSLS ---------- ---------- ---------- ---------- ---------- ---------- N--------- ---------- ---------- ------MMVS SSWWWDDKKR RRRYYYSSLA N--------- ---------- ---------- ------MMVS SSWWWDDQQR RRRYYYSSLA TNQQFYGLGM VVKKLNAAPP SGLLLEEIID DKEFFFVDGG ---RRSQVRG DYYYY----- SNQQFYGLGM AAKKVNVVPP EGLLLEELLE EKEFFFVDGG ---RRAQVRG DFFFY----- TDQQFYGVAQ VVLLAHAAPP DGLLLTTLLA ADDWWWVEPP GG-RRAQIRG DFFFYSKR-- TDQQFYGVGE VVMMANVVGG NGLLLEELLD DKDFFFVSPP GG-RRAQIRG DFFFYS---- TEQQFYDRAM VVMMANVVEE NGLLLTTLLD DKDWWWVDPP GG-RRSQIRG DFFFYS---- APQQFYGIGM VVKKLDAAPP NGIIIEEFFD DPKFFFLEPP GG-RRPQVRG DYYYY----- AEQQFYGIGM VVKKVDVVPP DGMMMQQFFD DPNFFFVDGG ---RRVQIRG DYYYF----- SEQQFYGIGI AAKKAEAAPP GGLLLSSLLD DPGFFFTEGG GG-RRPQIRG DYYYYS---- DKQQFYDLRG SSVVMLQQVV NGLLLKKLLN NPNLLLVDGG EELLLAELRG DWWW------ AKQQFYNLRG SSVVMLQQAA NGLLLKKLLN NPNLLLVDGG EELLLAELRG DWWW------ AKQQFYDLRG SSVVMLQQVV KGLLLKKLLN NPNLLLVDGG EELLLAELRG DWWW------ AKQQFYDLRG SSVVMLQQVV KGLLLTTLLN NPNLLLVDGG EELLLAELRG DWWW------ AKQQFYDLRG SSVVMLQQVV KGLLLKKLLN NPNLLLVDGG EELLLAELRG DWWW------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AKQQFYDLRG SSVVMLQQVV KGLLLKKLLN NPNLLLVDGG EELLLAELRG DWWW------ DKQQFYDLRG SSVVMLQQVV KGLLLKKLLN NPNLLLVDGG EELLLAEIRG DWWW------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKQQFYDMKG SSVVMLQQEE KGLLLKKLLN NPNLLLVDGG EEGLLAELRG DWWW------ IKQQFYDLKG AAVVMLQQKK KGLLLKKLLN NPNLLLVDGG EEDLLAEIRG DWWW------ AKQQFYGLEG SSHHILQQEE KGLLLKKIIN NPNFFFVDGG EEDLLAEMRG DWWW------ AKQQFYKLEG SSHHILQQEE NGLLLKKIIN NPNFFFVDGG EEDLLAEMRG DWWW------ ARQQFYELDG SSHHIIQQEE KGLLLSSIIN NPNFFFVDGG EEELLAEMRG DWWW------ AVSSFYEIEG SSHHIIQQEE KGLLLTTIIN NPDFFFVDGG EEDLLAEMRG DWWW------ REQQFYDLKG SSHHMLQQEE KGLLLSSIIN NPNFFFVDGG EEELLAEMRG DWWW------ KDQQFYEHKG AATTMVQQEE SGMMMEEIIN NRDLLLIDGG IIGLLAEMRG DWWW------ KDQQFYENRG AATTMLQQII TGMMMVVIIN NKNLLLIDGG VVGLLAEMRG DWWW------ TKQQFYNVKG SSVVMLQQEE KGLLLTTVVN NKNLLLVDGG EENLLADIRG DLLL------ PKQQFYEMAG GGTTIVQQEE NGMMMKKLLN NENLLLVDGG EEYLLPEMR- ---------- PKQQFYKMSG GGHHIVLLVV NGIIISSLLN NEDLLLVDAA EEYLLPEMRG DWWWAD---- ---------- ---------- ---------- ---------- ---------- ---------- N-------KG KKDDDAQQNN WDKKKEELLV VEDAAAVDYY LLLRRAIMRS S--------- N-------KG KKDDDEQQYY WDKKKEELLK KEQAAAIDYY EELRRPQMRR GAAADNLVQQ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- RVVVEEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNSAAKKKKP SAATPCRTVV VPTTLLADQR RTTTTTLSSL TGGPPPKAAY QQEAAFFSSA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------M AAGRSTTLPP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIQLLLAASP RSEEEKRRKR SSPPGGLLVV SAVVVVPPPP SSQQAAAAVV HHWLLPGGAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----ERGAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMGLLKEGHH ---------- ---------- ---------- ---------- ---------- KKNSSGCFDD ---------- ---------- ---------- ---------- ---------- ---------- LLNRRRTTTP HPNNNLPPAP PPPPRRVVPP RPTTTINNNN VVPPPPRRLL PPHAAHSLQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMRRG-- ---------- ---------- ---------- ---------- ---------- ---MMRFSGG ---------- ------MIIK KKRDPPTYPS PKMAPEEEEL LAAYACLLTG GNRRDDFFFI ---------- -------MMK KKPDPPTYPT PRDAPEEEEI IAAYAALLVG GNAADDFFFL ---------- ---------R RRPDPPTHAS PELAAEEEEF FAAYLLLLPD S-RRDDAAAL ---------- ---------R RRPDPPTHAS PKLAAEEEEF FAAYLLLLPD S-KKDDAAAL ---------- ---------R RRPDPPTYPS AKLGVEEEEL LAAFLMLLPD S-KKDDGGGL ---------- -------MMK KKPDPPSYPS PRLAPEEEEI IAAYAMFFPE K-QQDDAAAI ---------- -------MMR RRPDPPTYPS PRMAAEEEEL LAAYVRLLPM N-KKDDAAAM ---------- -------MMR RRPDPPTYPS PKMAREEEEL LGGYALLLPG E-RRDDAAAL ---------- ------TCC- --CGPPGPTP LEAGREEEEI IVVYPCIIRN GEAADDYYYL ---------- ---------- ---------- ---GREEEEI IVVYPCIIRN GEAADDYYYL AVLIAAAAAA RGLPGATCC- --CGPPGPSP LEAGREEEEI IVVYPCIIGN GEAADDYYYL ---------- ---------- ---------- ---GREEEEI IIIYPCIIRN GEAADDYYYL ---------- ------TCC- --CGPPGSTP LEAGREEEEI IVVYPCIIRN GEAADDYYYL FTLQSSSSAA QPRPISTCC- --CGPPGSTP LEAGREEEEI IVVYPCIIRN GEAADDYYYL ---------- ------TCC- --CGPPGSTP LEAG------ ---------- -EAADDYYYL ---------- ------TCC- --CGPPGSTP LEAGREEEEI IVVYPCIIRN GEAADDYYYL TAQPWWWWLL SGLWQDTCC- --CGPPGPTP QEAGREEEEI IVVYPCIIRN GEAADDYYYL QTNTEEEEHH TYTLVTTCC- --CGPPGSTP LEAGREEEEI IVVYPCIIRN GEAADDYYYL ---------- ------TCC- --CGPPGSTP LEAGREEEEI IVVYPCIIRN GEAADDYYYL HIMEGGGGAA AVTAAAKCCA AAKGPPGATP LEAGREEEEL LVVYTCVVNG GNKKDDYYYL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------ACC- --CGPPGKSP LDAGREEEEI IVVYPCIIRS GNKKDDYYYL --MATTTTLL DHVVNK-NNK KKSGPPGASP IESGREEEEL LIIYTAVVAG GEKKDDYYYL --MGTTTTLL QHVVSKNQQK KKSGPPGASP LEAGREEEEL LIIYTAVVAG GEKKDDYYYL ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------RRV VVGGPPGATP LAAGSEEEEL LIIYTAVVTG GDKKDDYYYL ---------- --MAAAACCA AATGPPGATP LEAGREEEEL LLLYTCVVNG GNKKDDYYYL ---------- ---MSNLCC- ---GPPGASP ADAGREEEEV VLLFTAPP-- ADGGDDAAAI ---------- ---MP-LCC- ---GPPGASP ADAGREEEEV VLLFTAPP-- ADGGDDAAAI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MEEK KKCGPPGATP LDAGVEEEEL LLLYVCVVPN DEHHDDYYYL ---------- ---------- ---------- ---GREEEEL LLLYVTVVPN DPHHDDYYYL ---------- ---------- ---MPPGIT- -DILDRRRRL LYYFNWLLGD RYDDTTDDDR ---------- -AAAGAMLLA AAFADDECQS PYMTQEEEEF FVVYWTLLVE MDEEDDKKKL PSMHFFFFLL RAVSGALAAV VVRADDECAS PYMTQEEEEY YVVYWTLLAE VDEEDDKKKL IIDDPPETTS SSKHKKKVVV EPYIIDDDEL LLLHHHHWWW NNCCCSAACC --NGG-KPPP LLDDPPPTTG GGKYKKKLLL DPYIIDDDEL LLLHHHHWWW NNCCCSAACC --NAA-KPPP LLDDPPSTTG GGKHTTTVVV TPNTTDDDEF FFFHHHHWWW NNCCCSSSSS --LTTGHAAA LLDDPPPTTG GGQHTTTVVV TPNKKDDDEF FFFHHHHWWW NNCCCSAASS --LAAGHAAA LLDDPPEKKG GGQHQQQLLL IPNKKDDDEF FFFHHHHWWW NNCCCSAASS --LTTGHAAA IIDDPPPRRA AASGQQQVVV APHAADDDEL LLLHHHHWWW NNCCCSCCCC --NAAPHPPP MMDDSSSTTG GGQGVVVTTT DPYTTGGGEL LLLHHHHWWW NNCCCSMMCC --NAAPHPPP LLDDPPGTTA AAQGRRRVVV EPNAADDDEL LLLHHHHWWW NNCCCSAACC --YAAPHPPP LLDDPPPQQS SSQHRRRLLL PPYLLDDDEL LLLHHHHWWW NNCCCSCC-- ---FFGDSSS LLDDPPPHHS SSQHRRRLLL PPHLLDDDEL LLLHHHHWWW NNCCCSCC-- ---FFGDSSS LLDDPPPQQC CCQHRRRLLL PPNLLDDDEL LLLHHHHWWW NNCCCSCC-- ---FFGDSSS LLDDPPPQQC CCQHRRRLLL PPHLLDDDEL LLLHHHHWWW NNCCCSCC-- ---YYGDIII LLDDPPPQQC CCQHRRRLLL PPNLLDDDEL LLLHHHHWWW NNCCCSCC-- ---FFGDSSS LLDDPPPQQC CCQE------ ---------- ---------- ---------- ---------- LLDDPPPQQC CCQHRRRLLL PPNLLDDDEL LLLHHHHWWW NNCCCSCC-- ---FFGDSSS LLDDPPPQQC CCQHRRRLLL PPNLLDDDEL LLLHHHHWWW NNCCCSCC-- ---FFGDSSS LLDDPPPQQS SSQHRRRLLL PPYLLDDDEL LLLHHHHWWW NNCCCSCC-- ---FFGDSSS LLDDPPPQQC CCQHRRRLLL PPNLLDDDEL LLLHHHHWWW NNCCCSCC-- ---FFGDSSS LLDDPPPQQC CCQHRRRLLL PPNLLDDDEL LLLHHHHWWW NNCCCSCC-- ---FFGDSSS LLDDPPPTTS SSQHRRRLLL PIHIIDDDKL LLLHHHHWWW NNCCCSCC-- ---HHGDPPP ---------- ---------- -PNTTDDDEL LLLHHHHWWW NNCCCSCC-- ---YYGDAAA LLDDPPPSSS SSQHRRRLLL PPNVVDDDEL LLLHHHHWWW NNCCCSCC-- ---YYGDSSS LLDDPPPTTS SSKHRRRLLL PPYVVDDDEL LLLHHHHWWW NNCCCSCC-- ---HHGDPPP LLDDPPPTTS SSKHRRRLLL PPYVVDDDEL LLLHHHHWWW NNCCCSCC-- ---HHGDPPP ---------- ---------- -PFVVDDDEL LLLHHHHWWW NNCCCSCC-- ---HHGDAAA LLDDPPPSSS SSSHRRRLLL PPFVVDDDEL LLLHHHHWWW NNCCCSCC-- ---HHGDAAA LLDDPPPTTS SSQHRRRLLL PTHVVDDDEL LLLHHHHWWW NNCCCSCC-- ---HHGDPPP IIDDPPDTTC CCQSRRRVVV DPHIIDDDEV VVVHHHHWWW NNCCCSCC-- ---HHDKPPP IINNPPETTC CCQSRRRVVV DPNIIDDDEV VVVHHHHWWW NNCCCSCC-- ---HHDKPPP ---------- ---------- ---------- ---------- ---------- ---------- LLDDPPPTTC CCQHRRRTTT YNSKKNNNEL LLLHHHHWWW NNCCCSCCFF VV-GGGKEEE LLDDPPPTTC CCQHRRRTTT FNRKKDDDEL LLLHHHHWWW NNCCCSCCYY VVESSSKTTT RRRRGGFLLG GGSKDDDGGG PKVLLDDDKE EEELLLLPPP TTRRRIKK-- -----GKRRR LLDDPPATTG GGQNSSSVVV SGG--NNNEA AAAHHHHFFF SS-------- ---------- LLDDPPPQQG GGKNTTTLLL SGG--NNNEA AAAHHHHFFF TT-------- ---------- NNNIRFFLPP GGGLSSSRII IIITKPNPPR EPPKKKKKVE EKKVGSRLTV CPPPDIYYSS FFFLRYYLPP AAALSSSRII IVVTKPDKKR RPPAAAAKIV VVGRGTKYTV CPPPDIYYSS FFFLRFFLPP GGGLSSSRIV VIITKPHPPT QAARRRRKIE ELAKGSRPTV CPPPEIYYSS FFFIRYYLPP GGGLSSSRII IIITKPDPPT KAAKKKKKIE EFKKGSRPTI CPPPDIYYSS FFFLRYYLPP GGGISSSRII IVVVK-EPPL KAAKKKKKIE EFAKGSRPTI CPPPEIYYSS HHHMRYYLPP GGGLSSSRII ILLTKPDPPL KPPFFFFKVT TAERGSRPTV CPPPGIYYTT HHHVRYYLPP DDDISSSHII ILLTKPDPPT QPPKKKKKVE EAERGARPTV CPPPDIYYSS HHHVRYYLPP GGGISSSRII IVVTKPDPPR EPPRRRRKVE EHRRGSRPTI CPPPDVYYSS TTTKRKKLPP GGGLSSSRIV VVVVGSEPPR APPKKKKKVE EQAKNSNTTS CAAASEVVVV TTTKRKKLPP SSSISSSRIV VVVVGSEPPR APPKKKKKVE EHAKNGNLTS CAAASEVVII TTTKRKKLPP CCCLSSSRIV VVVVGSDPPR APPKKKKKVD DHAKGGYVTS CAAASEVVII TTTKRKKLPP AAALSSSRIV VVVVGTEPPR APPKKKKKVD DHTKNGFFTS CPPPSEVVVV TTTKRKKLPP SSSLSSSRIV VVVVGSEPPR APPKKKKKVD DHAKEAFLTS CAAASEVVII ---------- ---------- ---------- ---------D DHAKEAFLTS CAAASEVVII TTTKRKKLPP SSSLSSSRIV VVVVGSEPPR APPKKKKKVD DHAKEAFLTS CAAASEVVII TTTKRKKLPP SSSLSSSRIV VVVVGSEPPR APPKKKKKVD DHAKEAFLTS CAAASEVVII TTTKRKKLPP SSSFSSSRIV VVVVGTEPPR APPKKKKKVD DHEKGGTPTS CPPPTEVVII TTTKRKKLPP SSSL------ ---------- ---------- ---------- ---------- TTTKRKKLPP SSSLSSSRIV VVVVGSEPPR APPKKKKKVD DHAKEAFLTS CAAASEVVII SSSARFFLPP SSSLSGGRVV VVVTATDPPR TPPSSSSKVD DAENGGFPTS CAAASDIIII SSSKRKKLPP CCCLSSSRIV VVVVGTDPPR APPRRRRKTE EFWKGANLTS CGGGCEIIII SSSKRKKLPP CCCLSSSRIV VVVVGSDPPR APPRRRRKTE EFWKGANPTS CGGGCEIIII SSSARFFLPP SSSLSGGRIV VIITKTNPPR SPPSSSSKVD DIQKGAYPTS CAAASELLII SSSARFFLPP GGGISGGRVV VIITKTNPPR APPSSSSKVD DSTKGAYPTS CAAASEIIII SSSARYYLPP SSSLSGGRIA AIITKENPPR APPSSSSKYE EAEKGAYPTA CAAASEIIVV SSSVRYYLPP SSSLSGGRIA AIITKENPPR APPSSSSKYE EADKGAFPTA CTTT-EIIVV SSSARFFLPP SSSLSGGRVV VVVTLKDPPR APPAAAAKVD DAEKGGFPTS CAAASEIIII TTTERHHLPP CCCLSDDRII IIIVENE--R KIIYYYYHTK KHSL-SFPTS CAAADNIIII TTTERHHLPP CCCLSDDRIV VIIVENE--R EIIYYYYHTK KHAL-SFPTS CAAADNIIII -------MRR KKKLSGGVEK KVVVGG---- ---------- ---------- ---------- VVVPRRRLPP CCCLSDDRIV VIITGTDPPR APPKKKKKVD DLKGDTAPTT CPPPNNIIII VVVPRRRLPP SSSLSDDFII ILLVVTDPPR KPPEEEEKTD DLKSNTAPTT CAAANNIIII VVVQGQQMLL SSSLGKKRLV VTTSLYSAAW DKKQQQQP-D DIKFVAISTA YPPPNALLQQ ----RFFFGG GGGLTNNRII IFFVHSDPPS NPPKKKKKTF FKDSGVGPTF APPPGMMMTT ----RYYLGG GGGLTSSKIV VFFVHSDPPA RPPVVVVKTF FEKSGVGPTL APPPGMLLTT SAGGN----- EEG-GPGIIM DHYFELGWWE EEEDGGDQ-- --AAYDDFWL PPNNVLLLVV SAGGG----- DDGRGPGIIL DHDFEIGWWE EEEYGGPQ-- --AAYDDFWL PPSSVMMMII STGGGGGKKK DDGTGAPIII DCEFDLGWWE EEEDGGPQ-- --HHYDDFWL PPRRYMMMVV STGGGGGKKK DDGTGPPVVI DCEFELGWWE EEEDGGPQ-- --HHYDDFWL PPRRYMMMVV STGGGGGEEE DDGTGPPIII DCEFELGYYE EEEDGGEQ-- --HHYDDFWL PPRRYMMMVV TAGGN----- EEG-GPGIIM DAQFELGWWE EEEEGGPQ-- --AAYDDGWL GGYYTLLLVV SAGGS----- EEG-GPGIII DHDLELGWWE EEEDGGDQ-- --HHYDDFWL GGYYTLLLLL SAGGS----- EEG-GPGVVV DHEFDLGWWE EEEEGGPQ-- --AAYDDFWL GGYYTMMMVV VNLLG----- LLQGGKGFFL DGEFEKGWWE EEEPGGAS-- --GGYDDFYP RRHHVMMMVV ISLLG----- PPQGGKGFFL DGEFEKGWWE EEEPGGEA-- --GGYDDFYP RRHHIMMMVV ISLLG----- SSKGGKGFFL DGEFEKGWWE EEEPGGAA-- --GGYDDFYP RRHHVMMMII VSLLG----- PPEGGKGFFL DGKFEKGWWE EEEPGGAA-- --GGYDDFYP RRHHVMMMII ISLLG----- VVKGGKGFFL DGEFEKGWWE EEEPGGAA-- --GGYDDFYP RRHHVMMMII ISLLG----- VVKGGKGFFL DGEFEKGWWE EEEPGGAA-- --GGYDDFYP RRHHVMMMII ISLLG----- VVKGGKGFFL DGEFEKGWWE EEEPGGAA-- --GGYDDFYP RRHHVMMMII ISLLG----- VVKGGKGFFL DGEFEKGWWE EEEPGGAA-- --GGYDDFYP RRHHVMMMII ISLLG----- PPKGGKGFFL DGEFEKGWWE EEEPGGSA-- --GGYDDFYP RRHHVMMMII ---------- ---------- ---------- ---------- ---------- ---------- ISLLG----- VVKGGKDSSV LP-LESG--- ---------- ---------- ---------- ISLLG----- KKEGAAGGGL LDSFNKGGGS SSSRFFPI-- --EERTTHYN AAWWLFFFWW ISIIG----- PPYGGKGFFL DGEFEKGWWE EEEEEEAA-- --GGYDDFYP RRHHVMMMII ISLLG----- PPCGGKGFFL DGEFEKGWWE EEEEEESA-- --GGYDDFYP RRHHVMMMII ISLLG----- KKDGAEGGGL LDSFNKGWWE EEEPHHSP-- --GGYDDFYP RRHHTMMMII ISIIG----- KKDGAEGGGL LDSFNKGWWE EEEPHHSP-- --GGYDDFYP RRHHTMMMII VSLLG----- EEEGAKGGGL LDSFNKNWWE EEEPHHSP-- --GGYDDFYP RRHHTMMMII VSLLG----- EEEGAKGGGL LDSFNKNWWE EEEPIISP-- --GGYHHFYP RRHHTMMMII ISLLG----- KKEGAAGGGL LDSFNKGWWE EEEPHHSP-- --GGYDDYYP RRHHTMMMII ISLLG----- AANGPSGFFL DGKFEKGWWP PPPDKKTV-- --NNYDDFYP RRRRVMMMII ISLLG----- AADGPSGFFL DGKFEKGWWP PPPDKKVV-- --NNYDDFYP RRRRIMMMII ---------- ---------- ---------- ---------- ---------- ---------- ISMMG----- AAEGAKGDDV FDKFEVGWWS SSSGRRKA-- --GGYDDYYP HHFFVMMMVV ISMMG----- AAEGAKGDDI FDSFNIGWWT TTTGKKKA-- --GGYDDFYP YYFFVMMMVV QDVVN----- SSLSPVLGGQ SKHNGSAGGE EEESFFEE-- --QQLSSNNG --RRKSSSEE TGSSN----- DDDHGRTLLE NDDEYATWWM MMMTDDDMGV VDGGYDDIAI RRKKVMMMLL TGSSN----- KKDHGRTLLE TNAEYATWWI IIITGGDLGI TDDDYDDVAP RRKKLLLLVV SEEEVPPTTE ED-LKKLEEH HLD-RYYGII HDDKRKRLLL LGGGEENRML L------ELR SEEEVPPCCE EE-FSSLEEC CLEGAYYGLL HDDKRRHLLL LGGGQEHRML L------EVR SEEELPPQQE EN-IVVPEED DLANKYYGLL HDDARRNLLL LGGGAQHQML L------EVR SEEELPPQQE EN-IVVPEED DLSNKYYGLL HDDARRNLLL LGGGANHQML L------EVR SEEELPPQQE EN-IVVPEED DLSNKYYGII HKKDRKNLLL LGGGANHQML L------EIR SEEETPPMME ED-LVVPDDI ILGARYYGLL HDDRRRHFFF FGGGDEHQLF F------ELR SEEETPPMME ES-VLLGDDE ELAGKYYGLL HDDRRRHLLL LGGGAEYQML L------ELR SEEETPPMME EG-LDDPQQI ILNKGYYGLL HDDRRRHVVV VGGGEEHQML L------ELR TEEEAPPVVK KDFNPPAHHV VE-GLYYGII FDDRHEIMMM MTTT--DGLP P----LLEIR TEEEAPPVVK KDFNPPAHHV VE-GLYYGII HDDRHEIMMM MKKK--DGLP P----LLEIR TEEEAPPVVR RDFNPPADDV VE-GLYYGLL HDDRHEILLL LQQQ--DGLP P----LLEIR TEEEAPPVVR RDFNPPADDV VK-GLYYGLL YDDRREILLL LQQQ--DGLP P----LLEIR TEEEAPPVVR RDFNPPADDV VE-GLYYGLL YDDHHEILLL LKKK--DGLP P----LLEIR TEEEAPPVVR RDFNPPADDV VE-GLYYGLL YDDRHEILLL LKKK--DGLP P----LLEIR TEEEAPPVVR RDFNPPADDV VE-GLYYGLL YDDRHEILLL LKKK--DGLP P----LLEIR TEEEAPPVVR RDFNPPADDV VE-GLYYGLL YDDRHEILLL LKKK--DGLP P----LLEIR TEEEAPPVVQ QNFNPPADDV VE-GLYYGLL HDDRHEIMMM MPPP--DGHP P----LLEIR ---------- ---------- ---------- ---------- ---------- ---------- AIIIHSSLLL LTSRDDYPPA AS-SRVVATT ---------- ---------- ---------- WIIICSSFFT TTAELLMCCL LT-SGVVHSS CNNMRVILLL LQQQ--DQAA ANNPILLCLR TEEEAPPAAA ALFKMMEEEV VQ-GMYYGLL NDDEHRRLLL LGGGE-DGLP P----LLEIR TEEEAPPAAA ALFKMMEDDV VQ-GHYYGLL NDDEHRLLLL LGGGK-DGLP P----LLEIR TSSSAPPAAT TKFDLLQHHV VA-GLYYGLL TQQRGELLLL LGGGN-TGLP P----LLEIR TSSSAPPAAL LQFNLLQHHV VA-GLYYGLL HSSGGEILLL LGGGD-KGLP P----LLEIR TSSSAPPAAS SKFDLLQHHV VA-GLYYGLL HSSGGEMLLL LGGGE-TGLP P----LLEIR TSSSAPPAAS SKFNLLQHHV VA-GLYYGLL HSSGGEILLL LGGGP-TGLP P----LLEIR SSSSAPPAAR RTFDLLQHHV VQ-GLYYGLL HDDGGELLLL LGGGS-TGLP P----LLEVR TEEESPPHHK KKFNPPAHHV VG-GLYYGVV HEESKKYLLL LPPPQPLGAP P----LLEVR TEEESPPHHK KKFNPPAHHV VP-GLYYGVV HEETKKHLLL LPPPMPRGAP P----LLEVR ILLLGPPTTC CREELLKCCQ QP-PLVVIKK R--------- ---------- ---------- SEEEAPPLLR RRYHPPTDDC CDRTQYYGLL NRRERELLLL LGGGD-DGLP P----LLEIR SEEEAPPKKR RRWKNNVDDL LEMSQYYGLL NKKTQTLLLL LGGGS-DGIP P----LLEIR DRRREPPMMF FESESSFLLK KKGPLKKPVV ALL------- ---------- ---------- SSSSGWWMMD DFQMLLQDDA AEMKRFFGII VDDTRQPVVV VPPPGAP--- -----LLEIR SSSSGWWMMD DFKMLLADDP PEMKHFFGVV VDDTKQPVVV VPPPGAP--- -----LLEIR RRPPLLHDDP PPTKGFFINM SLKDDSSSSS SWWLW-DNEE EKIIIIPEPE E-NPIILKPF RRPPLLHDDP PPTKGFFVNV NTKDDSSSSS SWWLW-DQEE ERIIIIEQPE E-PPVVLKDF RRPPAAHDDP PPVRGFFVGV DTTNNEEEEG SWWTW-GHKK KKAAAIPEPT TDEPLLLQGF RRPPAAHDDP PPVRGFFVGV DTTNNEEEEA SWWTW-GHEE EKAAAIPEPP PEKPLLLQGF RRPPAAHDDP PPSKGFFCGV DTTNNQQQQG AFFTWKDEKK KKIIIIDVPD DDDPLLLKGF RRPPAAHDDP PPTKGFFVNC SLKDDSSSSS SWWTW-KARR RKIIIIPEAD DDQPVVLKGF RRPPAAHDDP PPTKGFFMNC SLKDDSSSSA SWWLW-NHKK KKIIIIPEPS SDQPIILKPF RRPPAAHDDP PPARGFFVGV SLEDDSSSSA SWWLW-NGRR RKIIIIPEPE EDQPLLLKDF RRFFLLHDDP PPSAGFFVGC SSNIIRRRRF YNNEE----- --TTTSVKVQ QPSKKKGWML RRFFLLHDDP PPDAGFFVGC SSNIIRRRRF YNNEG----- --TTTSVKVQ QPSKKKGWML RRFFLLHNNP PPDAGFFVGC SSTIIRRRRF YNNQG----- --TTTSVKVQ QPPKKKGWML RRFFLLHNNP PPDAGFFVGC SSTIIRRRRF FNNED----- --TTTSAKVQ QPPKKKGWML RRFFLLHNNP PPDAGFFVGC SSTIIRRRRF YNNEG----- --TTTSVKVQ QPPKKKGWLL RRFFLLHNNP PPDAGFFVGC SSTIIRRRRF YNNEG----- --TTTSVKVQ QPPKKKGWLL RRFFLLHNNP PPDAGFFVGC SSTIIRRRRF YNNEG----- --TTTSVKVQ QPPKKKGWLL RRFFLLHNNP PPDAGFFVGC SSTIIRRRRF YNNEG----- --TTTSVKVQ QPPKKKGWLL RRFFLLHDDP PPAAGFFVGC SSTIIRRRRF YNNEG----- --TTTSVKVE EPPKKKGWML ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRSSIIHWWK KKNIDYYDVV SFSGGGGGGG SPPDA----- --AAAVLRKD DYYVAAKFGV RRFFLLHDDP PPDAGLLVGC SSTVVRRRRF YEEKD----- --KKKAAKVK KPSKEEGWAL RRFFLLHNNP PPDAGLLVGC SSSIIRRRRF YEEKD----- --KKKAAKVQ QPSKEEGWPM RRFFLLHDDP PPAKGFFVGS SSNMMRRRRF FTTQD----- --SSSSHLAP PKPKQQNWIL RRFFLLHDDP PPAKGFFVGS TSNMMRRRRF FTTQD----- --SSSNHIVS SEPKQQNWFL RRFFLLHDDP PPSKGYYVGS SSNMMRRRRF FNNSD----- --TTTSYIVS SKPKEENWIL RRFFLLHDDP PPSKGFFVGS SSNMMRRRRF FNNSD----- --TTTSHVVS SKPKEENWIL RRFFLLHDDP PPSKGYYVGC TSNMMRRRRF FTTAD----- --SSSSHVAS SKPKRRNWIL RRFFLLHEEP PPTSAFFVGC GSGIIRRRRI HVVEE----- -TTTTAALVF FPSKSSGWAL RRFFLLHEEP PPTSAFFVGC GSAIIRRRRI HDDEK----- -KVVVTALVT TPSKEENWAL ---------- ---------- ---------- ---------- ---------- ---------- RRFFLLHNNP PPREGYYVGC XXXXXXXXXX X--------- ---------- ---QEENGEI RRFFLLHNNP PPKKGFFVGC NAKVVHHHHF KKKSD----- -EEEEKKIDP PKLDGGSGVA ---------- ---------- ---------- ---------- ---------- ---------- RRFFPPWGGS SSNAAFFSTT TSQLLLLLLI YDDDA----- ---------E EQAAAADIGN RRCCAAWGGE EEAHCFFTST TSQLLLLLLI YDDGE----- ---------E EQAAAADIGE LLDIDDSSLL DDDDDKKYYL WIGGQDDIFF KKPGKLLGGG RRAADDHH-- ---------- LLDIDDSSLL DDDDDRRYYL WLGGQDDIHH QQPGRIIGGG RREEPPHH-- ---------- LLDIDDSSLL DDDDDRRYYC WTGGQDDVHH NNPGSIIGGG RRAAPPHH-- ---------- LLDIDDSSMM DDDDDRRYYC WTGGQDDVRR KKPGSIIGGG RRTTPPHH-- ---------- LLDIDDSSLL DDDDDKKYYC WLGGQDDVMM NNPGKIIGGG KKTTPPHH-- ---------- LLDIDDSSMM DDDDDRRYYC WTGGQDDVFF EEPGKIIGGG RRAATTHHG- ---------- LLDINNSSVV DDDDDRRYYC WTGGQDDVFF NNPGKIIGGG RRAAGGHH-- ---------- LLDINNSSLL DDDDDRRYYC WTGGQDDVFF NNPGSLLGGG KKAAAAHH-- ---------- LLDILLSSLL DDDDDRRYYN WHGGQDDIQQ KKPGQLLGGG RRGGGGSSQL EE--DQETTT LLDILLSSLL DDDDDRRYYN WHGGQDDIKK KKPGQLLGGG KKGGGGSSQL EE--DQETTT LLDILLSSLL DDDDDRRYYN WHGGQDDIQQ RRPGQLLGGG KKGGGGPPQL EE--DQEKKK LLDILLSSLL DDDDDHHYYN WHGGQDDVQQ RRPGQLLGGG KKDDGGPPQL DD--DQEDDD LLDILLSSLL DDDDDRRYYN WHGGQDDIQQ RRPGQLLGGG KKGGGGPPQL EE--DQEKKK LLDILLSSLL DDDDDRRYYN WHGGQDDIQQ RRP------- ---------- ---------- LL-------- ---------- ---------- ---------- ---------- ---------- LLDILLSSLL DDDDDRRYYN WHGGQDDIQQ RRPGQLLGGG KKGGGGPPQL EE--DEEKKK LLDILLSSLL DDDDDRRYYN WHGGQDDIKK RRPGQLLGGG KKGGGGPPQL EE--DQEKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EEPAWWFFFF SSDDDLLIIS ---------- ---------- ---------- ---------- LLDILLSSLL DDDDDRRYYN WHGGQDDIRR NNPGQLLGGG RRGGGGPPTL EE--DKDEEE LLDILLSSLL DDDDDRRYYN WHGGQDDIRR NNPGQLLGGG RRGGGGPPTL EE--DKEEEE LLDFLLSSLL DDDDDRRYYN WHGGQNNIKK NNPGQVVGGG KKGGSSPPAI GG--EDGTTT LLDFLLSSLL DDDDDRRYYN WHGGQNNIKK NNPGQAAGGG KKGGSSPPVV KK--DDGTTT LLDFLLSSLL DDDDDRRYYN WHGGQNNIKK NNPGQVVGGG KKGGSSPPKV GG--EDGSSS LLDFLLSSLL DDDDDRRYYN WHGGQNNIKK NNPGQVVGGG KKGGSSPPKV GG--EDGTTT LLDFVVSSLL DDDDDRRYYN WHGGQNNIAA KKPGQAAGGG KKGGSSEEVV TT--EDDEEE LLDILLSSMM DDDDDRRYYC WHGGQDDILL KKVSQIIGGG TTEESSNNKL EE--GEK--- LLDILLSSMM DDDDDRRYYC WHGGQDDIKK NNPSQIIGGG SSEETTTTKL EE--EDH--- ---------- ---------- ---------- ---------- ---------- ---------- MMDILLSSLL DDDDDRRYYN WHGGQDDIAA NNPGQLLGGG RRDDAAPPRL NN--DPEKKK MMDIIISSLL DDDDDRRYYC WHGGQDDIEE NNPGQLLGGG SSDDLLPPVV KKEEDKEKKK ---------- ---------- ---------- ---------- ---------- ---------- LLDISSAAAA DDDDDQQWWS FDGGLDDIHH KKPYEIIDDR ---------- ---------- LLDISSSSNN DDDDDSSWWT FDGGLDDIHH HHPYEIIGGA ---------- ---------- -------GHK KLLTAPPQML EIISDRRVVY YSLYYYSSTD DNQQYYYPPE GLKKKKLLNA -------GAE EAATAPPQMI SVVSDRRVVY YSLYYYSSSN NNQQYYYPP- GLRRKKVVNV -------GRT TFFAGPPQMV EIISDRRVVY YSLYYYSSTD DDQQYYYPPD GVPPLLAAHA -------GKA AFFAGPPQMV EIISDRRVVY YSLYYYSSTD DDQQYYYPPD GVPPMMAANV -------GKT TFFGGPPQMV EIISDKRVVY YSLYYYSSTD DEQQYYYPPG DRGGMMAANV -------NGA ALLNGPPQMV EIISDRRVVY YSLYYYGGAD DPQQYYYPPE GIDDKKLLDA -------SAE ELLNGPPQMV EIISDRRVVY YSLYYYRRAD DEQQYYYPPD GIKKKKVVDV -------SGP PLLNGPPQMV EVVSDRRVVY YSLYYYAASD DEQQYYYPPV GIRRKKAAEA QQPPPVVGKR RIIPGPPQMI QLLSDKRLLY YSLYYYSSDD DKQQYYY--P DLIIVVMMLQ QQPPPVVGKR RVVPGPPQMI QLLSDKRLLY YSLYYYSSAD DKQQYYY--P NLIIVVMMLQ QQPPPVVGKK KVVPGPPQMI QLLSDKRLLY YSLYYYSSAD DKQQYYY--P DLIIVVMMLQ QQPPPVVGKQ QVVAGPPQMI QLLSDKRLLY YSLYYYSSAD DKQQYYY--P DLIIVVMMLQ QQPPPVVGKR RVVAGPPQMI QLLSDKRLLY YSLYYYSSAD DKQQYYY--P DLIIVVMMLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQPPPVVGKR RVVAGPPQMI QLLSDKRLLY YSLYYYSSAD DKQQYYY--P DLIIVVMMLQ QQPPPVVGKR RVVPGPPQMI QLLSDKRIIY YSLYYYSSDD DKQQYYY--P DLIIVVMMLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQPPPIIGKK KVVPGPPQMI QLLSDKRLLY YSLYYYSSKD DKQQYYY--P DMIIVVMMLQ QQPPPTTGKI IIIPGPPQMI QLLSDKRIIY YSLYYYSSID DKQQYYY--P DLLLVVMMLQ QQSSSEEGQK KLLRGPPQMI QLLTDKRLLY YSLFFFSSAD DKQQYYY--P GLVVHHIILQ QQSSSEEGKK KLLRGPPQMI QLLSDKRLLY YSLFFFSSAD DKQQYYY--P KLVVHHIILQ QQFFFQQGKS SLLRGPPQMI QLLSDKRLLY YSLFFFSSAD DRQQYYY--P ELMMHHIIIQ QQFFFQQGKS SLLRGPPQMI QLLSDKRLLY YSLFFFSSAV VVSSYYY--P EIMMHHIIIQ QQYYYQQGHR RLLRGPPQMI QLLSDKRIIY YSLFFFSSRD DEQQYYYGGQ DLVVHHMMLQ PPIIIYYGRK KIIEGPPQML QLLSDKRLLY YSLYYYKKKD DDQQYYY--P EHVVTTMMVQ EEIIIYYGRQ QIIEGPPQML QLLSDKRLLY YSLYYYKKKD DDQQYYY--P ENVVTTMMLQ ---------- ----GPPAKI QLLSDKRLLY YSFYYYSSTD DKQQYYY--P NVVVVVMMLQ AAPPPFFGRR RLLLGPPQML QLLSDRRLLY YSLFFFSSPD DKQQYYY--P EMVVTTIIVQ RRPPPYYGRR RLLEGPPQML QLLSDKRLLY YSLYYYSSPD DKQQYYY--P KMVVHHIIVL ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MV SQQSDKRVVY YSLLLLAAND D--------- ----DDDDAQ ---------- --------MV SSSSDQRLLY YSLLLLAAND D--------- ----DDDDEQ N---PSGGED DKEFVDDDFE EEE------- --AARSSSHV VSSSSSYP-- ---------- N---PEGGEE EKEFVDDDFR RRR------- --AARAAAHV VWSTSSYP-- ---------- G---PDGGTA ADDYVEEEFD DDDGGGG--- --YYRAAAHI IESTSSYPSS SVVKKKKR-- G---GNGGED DKDYVSSSFD DDDGGGG--- --YYRAAAHI IESTSSYPSS SVV------- G---ENGGTD DKDFVDDDFA AAAGGGG--- --YYRSSSHI IESTSSYPSS SVV------- G---PNGGED DPKFLEEEWK KKKGGGG--- --HHRPPPHV VQSSSSYP-- ---------- N---PDGGQD DPNFVDDDFE EEE------- --QQRVVVHI IQSSSSFP-- ---------- D---PGGGSD DPGFTEEEVD DDDGGGG--- --LLRPPPHI IESSSSYPSS S--------- VDVVVNGGKN NPNFVDDDFK KKKEEEEPGP PPAALAAAHL LPSSII---- ---------- IDVVANGGKN NPNFVDDDFK KKKEEEEPGP PPAALAAAHL LPSSII---- ---------- IDVVVKGGKN NPNFVDDDFK KKKEEEEPGP PPAALAAAHL LPSSII---- ---------- IDVVVKGGTN NPNFVDDDFK KKKEEEEPGP PPAALAAAHL LPSSII---- ---------- VDVVVKGGKN NPNFVDDDFK KKKEEEEPGP PPAALAAAHL LPSSII---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VDVVVKGGKN NPNFVDDDFK KKKEEEEPGP PPAALAAAHL LPSSII---- ---------- IDVVVKGGKN NPNFVDDDFK KKKEEEEPGP PPAALAAAHI IPTSII---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IDVVEKGGKN NPNFVDDDFK KKKEEEEPGP PPVVLAAAHL LPSSII---- ---------- IDVVKKGGKN NPNFVDDDFK KKKEEEEPGP PPVVLAAAHI IPTSII---- ---------- IDVVEKGGKN NPNFVDDDFA AAAEEEEPGP PPAALAAAHM MPTSII---- ---------- IDVVENGGKN NPNFVDDDFA AAAEEEEPGP PPSSLAAAHM MPTSII---- ---------- IDVVEKGGSN NPNFVDDDFD DDDEEEEPGP PPAALAAAHM MPTSII---- ---------- IDGGEKGGTN NPDFVDDDFD DDDEEEEPGP PPSSLAAAHM MPTSII---- ---------- IDVVEKGGSN NPNFVDDDFA AAAEEEEPGP PPSSLAAAHM MPTSII---- ---------- VNIIESGKEN NRDFIDDDFK KKKIIIIEGP PPYYLAAAHM MPTSII---- ---------- IDVVITGHVN NKNFIDDDFK KKKVVVVPGP PPYYLAAAHM MPTSII---- ---------- IDVVEKGGTN NKNFVDDDFK KKKEEEEPGP PPCCLAAAHI IPTSII---- ---------- LDIIENGGKN NENFVDDDFG GGGEEEEPGP PPGGLPPPHM M--------- ---------- IDVVVNGGSN NEDFVDDDFN NNNEEEEPGP PPSSLPPPHM MPTSIIANDD DAA------- ---------- ---------- ---------- ---------- ---------- ---------- YLKKNWDGEV VEDFVDDDFE EEELLLLGG- ----RAAAHM MGYS------ ---------- FLKKYWDGEK KEQFIDDDFA AAAEEEEKG- ----RPPPHM MGYAPPDGNN NRRLLLLVQA ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AARRRRE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNNNSAKKAK KKKPEATTTT CCRRAAVTTL LTARLLLLAA AADDDDGGGA SLPTTTQQQL gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLSSLTPGSV RIAYQQQQEA TTFSAAIIQQ VLLLAPSEES SKRSLLLEES VVAKKQQVSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MAAAAGS PPTPPPLLNN NRRRTPPNNP PLPPVVVLLR RRPYYRRIVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MIVVP PKRDPFYPAA MMAADLYAAC CLLYGGRRAF ---------- ---------- ------MAAK KKPDPFYPAA MMAADIYAAA ALLYGGAAPF ---------- ---------- -------MMS SRPDPFHAAA MMAAEFYLLL LLLSSSRRPA ---------- ---------- -------MMT TRPDPFHAAA MMAANFYLLL LLLSSSKKPA ---------- ---------- -------MMT TRPDPFYPAA MMGGKLFLLM MLLSSSKKPG ---------- ---------- ------MAAT TKPDPFYPAA AAAATIYAAM MFFDKKQQPA ---------- ---------- ------MVVT TRPDPFYPAA VVAAKLYVVR RLLNNNKKPA ---------- ---------- ------MAAS SRPDPFYPAA MMAARLYAAL LLLDEERRPA ---------- ---------- -----TCTTK K-CGPYPTMM KKGGEIYPPC CIIYGGAAPY ---------- ---------- ---------- ---------- MMGGEIYPPC CIIYGGAAPY SVVVVHWWLP PPGKGLIAPA ARGLATCGGK K-CGPYPSMM KKGGEIYPPC CIIYGGAAPY ---------- ---------- ---------- --------MM KKGGEIYPPC CIIYGGAAPY ---------- ---------- -----TCGGN N-CGPYSTMM KKGGEIYPPC CIIYGGAAPY ---------A AERAGLQSVA AQPRSTCGGN N-CGPYSTMM KKGGEIYPPC CIIYGGAAPY ---------- ---------- -----TCGGN N-CGPYSTMM KKGG------ ------AAPY ---------- ---------- -----TCGGN N-CGPYSTMM KKGGEIYPPC CIIYGGAAPY -----MGGLG GKEEGQPWFL LSGLDTCGGD D-CGPYPTMM KKGGEIYPPC CIIYGGAAPY -----KNNSQ QGCLFNTELH HTYTTTCGGN N-CGPYSTMM KKGGEIYPPC CIIYGGAAPY ---------- ---------- -----TCGGN N-CGPYSTMM KKGGEIYPPC CIIYGGAAPY VLLLLPHHAR RHSLLMEGAA AAVTAKCCCH HAKGPYATMM EEGGKLYTTC CVVYGGKKLY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----ACGGS S-CGPYKSMM KKGGEIYPPC CIIYGGKKPY ---------- -----MATVL LDHVK-NGGC CKSGPYASMM SSGGSLYTTA AVVYGGKKPY ---------- -----MGTVL LQHVKNQGGC CKSGPYASMM SSGGTLYTTA AVVYGGKKPY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------RMML LVGGPYATMM SSGGKLYTTA AVVYGGKKPY ---------- ---------- ---MAACCCG GATGPYATMM EEGGKLYTTC CVVYGGKKPY ---------- ---------- ----NLCHHG G--GPYASII KKGGEVFTTA APP-AAGGPA ---------- ---------- -----LCHHG G--GPYASII KKGGEVFTTA APP-AAGGPA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MESSK KKCGPYATVV RRGGKLYVVC CVVQDDHHGY ---------- ---------- ---------- --------MM RRGGKLYVVT TVVQDDHHGY ---------- ---------- ---------- ---MPLITLL IILLFLFNNW WLLHRRDDID --------MK KRREG----- --AAAMLPPF FAFADTCQPP KKTTEFYWWT TLLGMMEEQK --------MK KRFISMHFAL LRAVALAPPA AVRADTCAKK KKTTDYYWWT TLLGVVEEQK FIVVNPPPKS TTKIHKVEEE LLYYYINHGN NNNAAAASSL --PGPNIIRR FLLRSSSRIY FLVVDPPPKS TTKVYKLDDD LLYYYIGHGN NNNAAAASSY --PAPFLLRR YLLRSSSRIY ALIVKPPPGS TTKIHTVTTT MMNNNTGHGN NNNAAAASSL --PTAFLLRR FLLRSSSRIY ALIVKPPPGS TTQIHTVTTT MMNNNKGHGN NNNAAAASSL --PAAFIIRR YLLRSSSRIY GLVVDPPPTS KKQIHQLIII MMNNNKGHGN NNNAAAASSL --PTAFLLRR YLLRSSSRIY AIVVDPPPAS RRSIGQVAAA MMHHHAGHGN NNNAAAASSL --PAPHMMRR YLLRSSSRIY AMVVDSSSQS TTQVGVTDDD MMYYYTGHGN NNNAAAASSL --PAPHVVRR YLLRSSSHIT ALLLDPPPDS TTQIGRVEEE MMNNNAAHGN NNNAAAASAL --PAPHVVRR YLLRSSSRIH YLVVDPPPKS QQQVHRLPPP MMYYYLKHGN NNNTTTTSS- ---FSTKKRN KLLMSSSRIY YLVVDPPPKS HHQVHRLPPP MMHHHLKHGN NNNTTTTSS- ---FSTKKRD KLLISSSRIY YLVIDPPPKS QQQVHRLPPP MMNNNLRHGN NNNAAAASS- ---FSTKKRT KLLMSSSRIY YLVVDPPPKS QQQVHRLPPP MMHHHLKHGN NNNTTTTSS- ---YITKKRT KLLISSSRIY YLVVDPPPKS QQQVHRLPPP MMNNNLKHGN NNNTTTTSS- ---FSTKKRT KLLISSSRIY YLVVDPPPKS QQQVE----- ---------- ---------- ---------- ---------- YLVVDPPPKS QQQVHRLPPP MMNNNLKHGN NNNTTTTSS- ---FSTKKRT KLLISSSRIY YLVVDPPPKS QQQVHRLPPP MMNNNLKHGN NNNTTTTSS- ---FSTKKRT KLLISSSRIY YLVVDPPPKS QQQVHRLPPP MMYYYLKHGN NNNTTTTSS- ---FSTKKRN KLLISSSRIY YLVVDPPPKS QQQVHRLPPP MMNNNLKHGN NNNTTTTSS- ---FSTKKRT KLL------- YLVVDPPPKS QQQVHRLPPP MMNNNLKHGN NNNTTTTSS- ---FSTKKRT KLLISSSRIY YLVLDPPPSS TTQVHRLPPP VVHHHIGHGN NNNSSSSSS- ---HPSAARR FLLLSSGRVY ---------- ---------- MMNNNTNHGN NNNTTTTSS- ---YASKKRN KLLISSSRIY YLVVDPPPKS SSQVHRLPPP MMNNNVNHGN NNNTTTTSS- ---YSSKKRN KLLISSSRIY YLVVDPPPSS TTKVHRLPPP VVYYYVGHGN NNNSSSSSS- ---HPSAARR FLLVSSGRIY YLVLDPPPNS TTKVHRLPPP VVYYYVGHGN NNNSSSSSS- ---HPSAARR FLLVSSGRVY ---------- ---------- MMFFFVGHGN NNNSSSSSS- ---HASAARR YLLISSGRIY YLVVDPPPSS SSSVHRLPPP MMFFFVGHGN NNNSSSSSS- ---HASVVRR YLLISSGRIY YLVVDPPPNS TTQVHRLPPP VVHHHVGHGN NNNAAAASS- ---HPSAARR FLLLSSGRVY AIVVNPPPES TTQVSRVDDD VVHHHIGHGN NNNAAAASS- ---HPTEERS HLLNSSDRIY AIVVNPPPES TTQISRVDDD VVNNNIGHGN NNNAAAASS- ---HPTEERS HLLNSSDRIY ---------- ---------- ---------- ---------- ---------- -MMSSSGVEG YLVVDPPPAS TTQVHRTYYY TTSSSKHHGN NNNTTTTSSH VVPGEVPPRD RLLNSSDRIF YLVVDPPPES TTQIHRTFFF TTRRRKGHGN NNNAAAASSY VVDSTVPPRD RLLNSSDFIY DRPMVGGGQV LLSVKDGPPP VVVVVLEDQT TTTPPPPIL- ----RVQQGP QMMDGGKRLY KLILRPPPGS TTQVNSVSSS VVGGG-RHGS SSSAAAA--- --------RR FFFDTTNRIF KLVANPPPKS QQKVNTLSSS VVGGG-RHDT TTTDDDD--- --------RR YLLDTTSKIF IIIIDTTPRR RKIVPEVKKK VYSRRRLVVP DAIIYISGGG GE----EEG- -EGGGGGGGG IIIVDTTKRR RAVIPVAVGG RYTKKKYVVP DAIIYISGGG GP----DDGR REGGGGGGGG VVVIDTTPTT TRIIPEILAA KYSRRRPVVP EGIIYVSGGG GAGGKKDDGT TDGGGGGGGG IIIIDTTPTT TKIIPEVFKK KYSRRRPIIP DGIIYVSGGG GGGGKKDDGT TNGGGGGGGG IIIVDVVPLL LKIIPEVFAA KYSRRRPIIP EGIIYVSGGG GGGGEEDDGT TDGGGGGGGG IIILDTTPLL LFLVPTLAEE RYSRRRPVVP GGIIYVTGGG GA----EEG- -KGGGGGGGG IIILDTTPTT TKVVPELAEE RYARRRPVVP DGIIYISGGG GP----EEG- -EGGGGGGGG IIIVDTTPRR RRIVPELHRR RYSRRRPIIP DGVVYVSGGG GP----EEG- -DGGGGGGGG VVVVDVVPRR RKLVAEIQAA KVSNNNTSSA SGEEVMVLLL LD----LLQG GNGGGSSSSS VVVVDVVPRR RKLVPEIHAA KLGNNNLSSA SGEEVMILLL LD----PPQG GNGGGGGGGG VVVVDVVPRR RKLVADIHAA KLGYYYVSSA SGEEVMILLL LD----SSKG GNGGGGGGGG VVVVDVVPRR RKLVPDIHTT KLGFFFFSSP SGEEVMVLLL LD----PPEG GNGGGGGGGG VVVVDVVPRR RKLVPDIHAA KLAFFFLSSA SGEEVMILLL LD----VVKG GNGGGGGGGG ---------- ----PDIHAA KLAFFFLSSA SGEEVMILLL LD----VVKG GNGGGGGGGG VVVVDVVPRR RKLVPDIHAA KLAFFFLSSA SGEEVMILLL LD----VVKG GNGGGGGGGG VVVVDVVPRR RKLVPDIHAA KLAFFFLSSA SGEEVMILLL LD----VVKG GNGGGGGGGG VVVVDVVPRR RKLVADIHEE KLGTTTPSSP TGEEVMILLL LD----PPKG GNGGGGGGGG ---------- ---------- ---------- ---------- ---------- ---------- VVVVDVVPRR RKLVPDIHAA KLAFFFLSSA SGEEVMILLL LD----VVKG GNGGGGGGGG VVVVDTTPRR RSLVSDIAEE NLGFFFPSSA SGDDIMILLL LD----KKEG GNAAANNNNN VVVVDVVPRR RRITPEVFWW KLANNNLSSG CGEEIMIIII ID----PPYG GNGGGGGGGG VVVVDVVPRR RRITPEVFWW KLANNNPSSG CGEEIMILLL LD----PPCG GNGGGGGGGG VVVIDTTPRR RSLVPDIIQQ KLAYYYPSSA SGEELMILLL LD----KKDG GNAAANNNNN VVVIDTTPRR RSLVPDISTT KLAYYYPSSA SGEEIMIIII ID----KKDG GNAAANNNNN AAAIDTTPRR RSLYPEIAEE KLAYYYPAAA SGEEILVLLL LD----EEEG GNAAANNNNN AAAIDTTPRR RSLYPEIADD KLAFFFPAAT -GEEILVLLL LD----EEEG GNAAANNNNN VVVVDTTPRR RALVADIAEE KLGFFFPSSA SGEEIMILLL LD----KKEG GNAAANNNNN IIIINVV-RR RYLTPKLHSS LLSFFFPSSA DGNNIMILLL LE----AANG GTPPPNNNNN VVVINVV-RR RYLTPKLHAA LLSFFFPSSA DGNNIMILLL LE----AADG GSPPPNNNNN KKKVFVV--- ---------- ---------- ---------- ---------- ---------- VVVIDTTPRR RKLVGDVLKK GCTAAAPTTP NGNNIMIMMM MD----AAEG GNAAA----- IIILDVVPRR REITGDVLKK SVTAAAPTTA NGNNIMIMMM MD----AAEG GYAAA----- VVVTTSSAWW WQF--DLIKK FLAIIISAAP NTAALKQVVV VE----SSLS SVPPPNNNNN IIIFDVVPSS SKLTTFVKDD SVVGGGPFFP GSMMMITSSS SD----DDDH HGGGGAAAAA VVVFDVVPAA AVLTDFVEKK SVVGGGPLLP GRMMLITSSS SN----KKDH HGGGGAAAAA ILLMMDDDHY YEEEPLLLGG GEIIRRGDDY ---------- ----LYYYDD DFWWNN-PEV IFFLLDDDHD DEEEPIIIGG GEVVRRGPPY ---------- ----FYYYDD DFWWNN-PGI IFFIIDDDCE EDDDVLLLGG GEIIRRGPPD ---------- ----KYYYDD DFWWNN-PDV VFFIIDDDCE EEEEVLLLGG GEIIRRGPPT ---------- ----LYYYDD DFWWNN-PDV IFFIIDDDCE EEEEILLLGG GEMMRRGEET ---------- ----KYYYDD DFWWNN-PDV IAAMMDDDAQ QEEEPLLLGG GEVVRRGPPY ---------- ----FYYYDD DGWWHH-GDV IFFIIDDDHD DEEEVLLLGG GEIIRRGDDY ---------- ----LYYYDD DFWWHH-GDL VFFVVDDDHE EDDDPLLLGG GEVVRRGPPQ ---------- ----LYYYDD DFWWHH-GDV FVVLLDDDGE EEEEVKKKGG GEKKGGGAAP ---------- ----MYYYDD DFYYQQ-RNV FVVLLDDDGE EEEEVKKKGG GEKKGGGEEP ---------- ----MYYYDD DFYYQQ-RNV FVVLLDDDGE EEEEVKKKGG GEQQGGGAAP ---------- ----MYYYDD DFYYQQ-RNI FVVLLDDDGK KEEEVKKKGG GEQQGGGAAP ---------- ----LYYYDD DFYYQQ-RNI FVVLLDDDGE EEEEVKKKGG GERRGGGAAP ---------- ----SYYYDD DFYYQQ-RNI FVVLLDDDGE EEEEVKKKGG GERRGGGAAP ---------- ----LYYYDD DFYYQQ-RNI FVVLLDDDGE EEEEVKKKGG GERRGGGAAP ---------- ----LYYYDD DFYYQQ-RNI FVVLLDDDGE EEEEVKKKGG GERRGGGAAP ---------- ----LYYYDD DFYYQQ-RNI FVVLLDDDGE EEEEVKKKGG GERRGGGSSP ---------- ----MYYYDD DFYYQQ-RNI ---------- ---------- ---------- ---------- ---------- ---------- SLLVVLLLP- -EEECSSSGG G--------- ---------- ---------- ---------- GFFLLLLLDS SNNNVKKKGG GSNNLLFPPS ---------- ----KRRRTT THYYEEYAGW FVVLLDDDGE EEEEVKKKGG GEAAGGEAAP ---------- ----FYYYDD DFYYQQ-RNI FVVLLDDDGE EEEEVKKKGG GEVVGGESSQ ---------- ----FYYYDD DFYYQQ-RNI GFFLLLLLDS SNNNVKKKGG GEKKGGHSSL ---------- ----FYYYDD DFYYQQ-RNI GFFLLLLLDS SNNNVKKKGG GEKKGGHSSL ---------- ----FYYYDD DFYYQQ-RNI GFFLLLLLDS SNNNIKKKNN NEKKGGHSSL ---------- ----FYYYDD DFYYQQ-RKI GLLLLLLLDS SNNNIKKKNN NEKKDDISSL ---------- ----YYYYHH HFYYQQ-RKI GFFLLLLLDS SNNNVKKKGG GEKKGGHSSL ---------- ----FYYYDD DYYYQQ-RKI FLLLLDDDGK KEEEPKKKGG GPAAEEKTTP ---------- ----FYYYDD DFYYQQ-RNI FLLLLDDDGK KEEEPKKKGG GPAAGGKVVP ---------- ----FYYYDD DFYYQQ-RNI ---------- ---------- ---------- ---------- ---------- ---------- DFFVVFFFDK KEEELVVVGG GSRRDDRKKL ---------- ----CYYYDD DYYYQQ-HNV DFFIIFFFDS SNNNCIIIGG GTKKDDKKKL ---------- ----CYYYDD DFYYQQ-YDV GIIQQSSSKH HGGGLSSSAA AEAAQQFEEI ---------- ----LLLLSS SNNNNN--EE LVVEENNNDD DYYYVAAATT TMPPAADDDQ GGAVAGAVVA AAAGYYYYDD DIAALL-RNL LVVEETTTNA AYYYVAAATT TIPPDDGDDR GGAIKGKYYA AAAGYYYYDD DVAALL-RNV EEAAAP--II E----LLKKL LELKDDRYYG GRRRFFFFWL LLRRRKRRHH TTTTENNML- EETTTP--FF E----FFSSL LELKEEAYYG GKKKVVVVWL LLAARRHHYY DDDDEHHML- EEAAAP--FF E----IIVVP PELLAAKYYG GRRRFFFFWL LLRRRRNNQQ DDDDQHHML- EEAAAP--FF E----IIVVP PELLSSKYYG GRRRFFFFWL LLRRRRNNQQ DDDDNHHML- EEGGGP--FF E----IIVVP PELLSSKYYG GKKKFFFFWL LLRRRKNNQQ DDDDNHHML- EEGGGP--VV E----LLVVP PDLLGGRYYG GRRRFFFFWL LLTTRRHHQQ DDDDEHHLF- EEGGGP--VV E----VVLLG GDLLAAKYYG GRRRVVVVWL LLYYRRHHQQ DDDDEYYML- EEGGGP--II E----LLDDP PQLLNNGYYG GRRRIIIIWL LLRRRRHHQQ DDDDEHHML- EEAAAP--FF KFFFFNNPPA AHEA--LYYG GRRRVVVVWW WWQQHEIIQQ QQQQ-DDLP- EEAAAP--FF KFFFFNNPPA AHEA--LYYG GHHHVVVVWW WWQQHEIIQQ QQQQ-DDLP- EEAAAP--FF RFFFFNNPPA ADEA--LYYG GHHHVVVVWW WWQQHEIIQQ TTTT-DDLP- EEAAAP--LL RFFFFNNPPA ADKA--LYYG GHHHVVVVWW WWQQREIIQQ PPPP-DDLP- EEAAAP--LL RFFFFNNPPA ADEA--LYYG GHHHVVVVWW WWQQHEIIQQ SSSS-DDLP- EEAAAP--LL RFFFFNNPPA ADEA--LYYG GHHHVVVVWW WWQQHEIIQQ SSSS-DDLP- EEAAAP--LL RFFFFNNPPA ADEA--LYYG GHHHVVVVWW WWQQHEIIQQ SSSS-DDLP- EEAAAP--LL RFFFFNNPPA ADEA--LYYG GHHHVVVVWW WWQQHEIIQQ SSSS-DDLP- EEAAAP--VV QFFFFNNPPA ADEA--LYYG GHHHVVVVWW WWQQHEIIQQ LLLL-DDHP- ---------- ---------- ---------- ---------- ---------- ---------- IIAAAS--RR LSSSSRRDDY YPSA--RVVA AIII------ ---------- ---------- IICCCS--YY TAAAAEELLM MCTA--GVVH HIIILLLLDY YYIIRVIIEE PPPP-DDAAN EEGGGP--FF AFFFFKKMME EEQA--MYYG GSSSVVVVWW WWTTHRRRQQ DDDD-DDLP- EEGGGP--FF AFFFFKKMME EDQA--HYYG GSSSVVVVWW WWTTHRLLQQ DDDD-DDLP- SSGGGP--FF TFFFFDDLLQ QHAD--LYYG GHHHCCCCIL LLAAGELLQQ DDDD-TTLP- SSGGGP--FF LFFFFNNLLQ QHAD--LYYG GHHHVVVVYW WWPPGEIIQQ DDDD-KKLP- SSGGGP--FF SFFFFDDLLQ QHAD--LYYG GHHHVVVVYW WWPPGEMMQQ DDDD-TTLP- SSGGGP--FF SFFFFNNLLQ QHAD--LYYG GHHHVVVVYW WWPPGEIIQQ DDDD-TTLP- SSGGGP--FF RFFFFDDLLQ QHQD--LYYG GHHHVVVVYW WWPPGELLQQ DDDD-TTLP- EEGGGP--II KFFFFNNPPA AHGE--LYYG GSSSIIIIFW WWDDKKYYQQ DDDDPLLAP- EEGGGP--II KFFFFNNPPA AHPE--LYYG GSSSIIIIFW WWDDKKHHQQ DDDDPRRAP- LLGGGP--VV CEEEEEELLK KCPE--LVVI ICCCVVVVY- ---------- ---------- EEGGGP--FF RYYYYHHPPT TDDDRRQYYG GRRRFFFFYW WWQQRELLQQ DDDD-DDLP- EEGGGP--WW RWWWWKKNNV VDEDMMQYYG GRRRFFFFYW WWSSQTLLQQ DDDD-DDIP- RRDDDP--AA FSSSSEESSF FLKTGGLKKP PHHHEEEEV- ---------- ---------- SSTTTWYYMM DQQQQMMLLQ QDEAMMRFFG GTTTQQQQWL LLHHRQPPKK NNNNAPP--- SSTTTWYYMM DKKKKMMLLA ADEAMMHFFG GTTTTTTTWL LLHHKQPPKK DDDDAPP--- PLDPPTTTKK LMMMINNVSS LLKDDLWLLY -EEKWNNNNN NAAEIEPPPA LLGG-NNPEI PLDPPTTTKK LMMMVNNVNN TTKDDLWLLY -EEKWQQQQQ QAAEIDEEEA FFGG-PPPPV PADPPVVVRR EYYYVGGVDD TTTNNLWTTR -EEKFHHHHH HVVKATPPPA AAAADEEPPL PADPPVVVRR EYYYVGGVDD TTTNNLWTTR -EEKFHHHHH HAAEATPPPP AAKKEKKPPL PADPPSSSKK DYYYCGGVDD TTTNNLFTTQ KDDTFEEEEE EAAKITDDDP AAAADDDPDL PADPPTTTKK AYYYVNNVSS LLKDDLWTTR -DDKWAAAAA AVVRIEPPPA AAPPDQQPPV PADPPTTTKK AYYYMNNVSS LLKDDLWLLR -DDSWHHHHH HLLKIDPPPA AAEEDQQPPI PADPPAAARR TYYYVGGVSS LLEDDLWLLR -QQSWGGGGG GIIRIEPPPA AAPPDQQPPL FLDPPSSSAA TQQQVGGASS SSNIIQNEE- ---------- ----TWVVVE IIVVPSSKVK FLDPPDDDAA TQQQVGGASS SSNIIQNEE- ---------- ----TWVVVE IIVVPSSKVK FLNPPDDDAA AQQQVGGASS SSTIIQNQQ- ---------- ----TWVVVE IIVVPPPKVK FLNPPDDDAA AQQQVGGASS SSTIIQNEE- ---------- ----TWAAAQ IIVVPPPKVK FLNPPDDDAA AQQQVGGASS SSTIIQNEE- ---------- ----TWVVVE IIVVPPPKVK FLNPPDDDAA AQQQVGGASS SSTIIQNEE- ---------- ----TWVVVE IIVVPPPKVK FLNPPDDDAA AQQQVGGASS SSTIIQNEE- ---------- ----TWVVVE IIVVPPPKVK FLNPPDDDAA AQQQVGGASS SSTIIQNEE- ---------- ----TWVVVE IIVVPPPKVK FLDPPAAAAA SQQQVGGASS SSTIIQNEE- ---------- ----TWVVVE IIVVPPPKVK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SIWKKNNNII NQQQDVVESS FFSGGRPDD- ---------- ----AVLLLK LLLLYYYVVA FLDPPDDDAA AQQQVGGASS SSTVVFEKK- ---------- ----KWAAAE IIVVPSSKVE FLNPPDDDAA DQQQVGGASS SSSIIFEKK- ---------- ----KWAAAE IIVVPSSKVE FLDPPAAAKK DTTTVGGASS SSNMMITQQ- ---------- ----SWHHHE IIVVKPPKVQ FLDPPAAAKK DTTTVGGATT SSNMMITQQ- ---------- ----SWHHHE IIVVEPPKVQ FLDPPSSSKK DTTTVGGASS SSNMMINSS- ---------- ----TWYYYE IIVVKPPKVE FLDPPSSSKK DTTTVGGASS SSNMMINSS- ---------- ----TWHHHE IIVVKPPKVE FLDPPSSSKK DTTTVGGATT SSNMMVTAA- ---------- ----SWHHHE IIIIKPPKVR FLEPPTTTSS EHHHVGGAGG SSGIIFVEES ---------- ----THAAAT AAIIPSSKVS FLEPPTTTSS EHHHVGGAGG SSAIIFDEEP ---------- ----VQAAAS AAIIPSSKVE ---------- ---------- ---------- ---------- ---------- ---------- FLNPPRRREE NQQQVGGAXX XXXXXX---- ---------- ---------- -------QGE FLNPPKKKKK AEEEVGGANN AAKVVFKSSD ---------- ----EAKKKV IIGGKLLDTG ---------- ---------- ---------- ---------- ---------- ---------- FPGSSNNNAA NYYYSTTATT SSQLLWDDD- ---------- ---------- --WWQAAAVA CAGEEAAAHH NYYYTSSATT SSQLLWDGG- ---------- ---------- --WWQAAAVA LLPFVPPLVV VTDDIDSLDF FLLSWIIGGE RDDDINPFPP VVVLLGVKKL LLGGGFFRRA LLDFVPPLVV VTDDIDSLDF FLVSWLLGGE RDDDINPHPP RRRLLGVKKI IIGGGYYRRE LLGFVPPLVV VTDDIDSLDF FLVSWTTGGE RDDDVDPHPP VVVLLGVRRI IIGGGAARRA LLGFVPPLVV VTDDIDSMDF FLVSWTTGGE RDDDVDPRPP KKKLLGVHHI IIGGGAARRT LLGFCPPLVV VTDDIDSLDY YLVAWLLGGE HDDDVDPMPP VVVLLGVEEI IIGGGVVKKT LLGFVPPLVV VTDDIDSMDF FLVSWTTGGD LDDDVDPFPP KKKLLGVRRI IIGGGVVRRA LLPFVPPLVV VTDDINSVDF FLVSWTTGGE HDDDVDPFPP RRRLLGVQQI IIGGGVVRRA LLDFVPPLVV VTDDINSLDF FLVSWTTGGE RDDDVDPFPP RRRHHGVRRL LLGGGVVKKA GGMLMPGLII ITDDILSLDF FLFSWHHGGD RDDDINPQPP RRRLLGIFFL LLGGGIIRRG GGMLMPGLII ITDDILSLDF FLFSWHHGGD RDDDINPKPP RRRLLGIFFL LLGGGIIKKG GGMLMPGLII ITDDILSLDF FLFSWHHGGD RDDDIDPQPP RRRLLGLFFL LLGGGIIKKG GGMLMPGLII ITDDILSLDF FLFSWHHGGD RDDDVDPQPP RRRLLGLFFL LLGGGIIKKD GGLLMPGLII ITDDILSLDF FLFSWHHGGD RDDDIDPQPP RRRLLGLFFL LLGGGIIKKG GGLLMPGLII ITDDILSLDF FLFSWHHGGD RDDDIDPQPP RRRLL----- ---------- GGLLMPGLII IT-------- ---------- ---------- ---------- ---------- GGLLMPGLII ITDDILSLDF FLFSWHHGGD RDDDIDPQPP RRRLLGLFFL LLGGGIIKKG GGMLMPGLII ITDDILSLDF FLFNWHHGGD RDDDIDPKPP RRRLLGIFFL LLGGGIIKKG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKGVLSNEFF FPPPAWFFSL LIFL------ ---------- ---------- ---------- GGALMPGLII ITDDILSLDF FLFSWHHGGD RDDDIDPRPP KKKLLGIFFL LLGGGIIRRG GGPMMPGLII ITDDILSLDF FLFSWHHGGD RDDDIDTRPP KKKLLGIFFL LLGGGIIRRG NNILMPGLII ITDDFLSLDF FLFVWHHGGD RNNNIDLKPP VVVLLGLWWV VVGGGIIKKG NNFLMPGLII ITDDFLSLDF FLFVWHHGGD RNNNIDVKPP KKKLLGVWWA AAGGGIIKKG NNILMPGLII ITDDFLSLDF FLFVWHHGGD RNNNIDPKPP VVVLLGIWWV VVGGGLLKKG NNILMPGLII ITDDFLSLDF FIFVWHHGGD RNNNIDPKPP VVVLLGIWWV VVGGGLLKKG NNILMPGLII ITDDFVSLDY YLLVWHHGGD RNNNIDPAPP VVVLLGVWWA AAGGGLLKKG GGALMPALII ITDDILSMDF FLVSWHHGGD RDDDIDPLVV KKKLLSVYYI IIGGGVVTTE NNALMPALII ITDDILSMDF FLVSWHHGGD RDDDIDPKPP KKKLLSVFFI IIGGGIISSE ---------- ---------- ---------- ---------- ---------- ---------- NNEIMGGMMM MTDDILSLDY YLFSWHHGGD RDDDIDRAPP RRRLLGVFFL LLGGGIIRRD SSVAMGGMII ISDDIISLDF FLVNWHHGGD RDDDIDPEPP KKKLLGLFFL LLGGGIISSD ---------- ---------- ---------- ---------- ---------- ---------- DDGNDIPLPP PVDDISAADT TLINFDDGGK RDDDIDPHPP FFFQQYKVVI IIDDRVV--- DDGEKVPLPP PVDDISSNDR RLVNFDDGGK RDDDIDPHPP RRRQQYKTTI IIGGAVV--- DPPPPP---- -------AAG KLLTGGPPPQ QEIRRDGGGR VVYYTTNSSL YTWQQFFFYP PPPPPP---- -------SSG EAATGGPPPQ QSVRRDGGGR VVYYTTNSSL YSWQQFFFYP PPPPPP---- -------NNG TFFAGGPPPQ QEIRRDGGGR VVYYTTNSSL YTWQQFFFYP PPPPPP---- -------NNG AFFAAAPPPQ QEIRRDGGGR VVYYTTNSSL YTWQQFFFYP PPPPPP---- -------NNG TFFGYYPPPQ QEIRRDGGGR VVYYTTNSSL YTWQQFFFYP TPPPPP---- -----AAKKN ALLNGGPPPQ QEIRRDGGGR VVYYTTNSSL YAVQQFFFYP GPPPPP---- -----AATTS ELLNGGPPPQ QEIRRDGGGR VVYYTTNSSL YAWQQFFFYP APPPPP---- -------AAS PLLNGGPPPQ QEVRRDGGGR VVYYSSNSSL YSWQQFFFYP GVVVVVLE-- DTTPLVVKKG RIIPGGPPPQ QQLLLDGGGR LLYYTTTSSL YDWQQFFFY- GVVVVVLE-- DTTPLVVKKG RVVPGGPPPQ QQLLLDGGGR LLYYTTTSSL YAWQQFFFY- GVVVVVLE-- DKKPLVVKKG KVVPGGPPPQ QQLLLDGGGR LLYYTTTSSL YAWQQFFFY- GVVVVVLD-- DDDPLVVKKG QVVAGGPPPQ QQLLLDGGGR LLYYTTTSSL YAWQQFFFY- GVVVVVLE-- DKKPLVVKKG RVVAGGPPPQ QQLLLDGGGR LLYYTTTSSL YAWQQFFFY- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GVVVVVLE-- DKKPLVVKKG RVVAGGPPPQ QQLLLDGGGR LLYYTTTSSL YAWQQFFFY- GVVVVVLE-- DKKPLVVKKG RVVPGGPPPQ QQLLLDGGGR IIYYTTTSSL YDWQQFFFY- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GVVVVVLE-- DEEPVVVKKG KVVPGGPPPQ QQLLLDGGGR LLYYTTNSSL YKWQQFFFY- GVVVVVLE-- DEEPVVVKKG IIIPGGPPPQ QQLLLDGGGR IIYYTTSSSL YIWQQFFFY- SVVVVVIG-- ETTSPIIQQG KLLRGGPPPQ QQLLLDGGGR LLYYTTNSSL FAWQQFFFY- SVVVVVVK-- DTTSPIIQQG KLLRGGPPPQ QQLLLDGGGR LLYYTTNSSL FAWQQFFFY- SVVVVVVG-- ESSFPIIKKG SLLRGGPPPQ QQLLLDGGGR LLYYTTNSSL FAWQQFFFY- SVVVVVVG-- ETTFPIIKKG SLLRGGPPPQ QQLLLDGGGR LLYYTTNSSL FAWSSFFFY- SVVVVVVT-- EEEYPVVKKG RLLRGGPPPQ QQLLLDGGGR IIYYTTNSSL FRWQQFFFYG SVVVVVLE-- G--ILVVKKG KIIEGGPPPQ QQLLLDGGGR LLYYTTTSSL YKWQQFFFY- TVVVVVLE-- E--ILVVKKG QIIEGGPPPQ QQLLLDGGGR LLYYSSTSSL YKWQQFFFY- ---------- ---------- ----GGPPPA AQLVVDGGGR LLYYTTNSSF YTWQQFFFY- ARRRRRLN-- DKKPVLLKKG RLLLGGPPPQ QQLLLDGGGR LLYYSSSSSL FPWQQFFFY- LNNNNNVKEE DKKPRVVKKG RLLEGGPPPQ QQLLLDGGGR LLYYSSSSSL YPWQQFFFY- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -SQWWDGGGR VVYYSSSSSL LNW------- ---------- ---------- ---------- -SSWWDGGGR LLYYTTSSSL LNW------- PLLLKGWMMK LNN--PPSSG EDDFFDDFGE E-----ASSH RRLLSSSSGD DASSSSDSYY PLLLRGWMMK VNN--PPEEG EEEFFDDFGR R-----AAAH RRLLWWWWGD DASSTTDSFF PVVVPAAQQL AHG--PPDDG TAAYWEEFPD D-----YAAH RRLLEEEEGD DCSSTTDSFF PVVVPGVEEM ANG--GGNNG EDDYFSSFPD D-----YAAH RRLLEEEEGD DCSSTTDSFF PRRRGAAMMM ANG--EENNG TDDFWDDFPA A-----YSSH RRLLEEEEGD DCSSTTDSFF PIIIDGWMMK LDG--PPNNG EDDFFEEWPK K-----HPPH RRLLQQQQGD DCSSSSDSYY PIIIKGWMMK VDN--PPDDG QDDFFDDFGE E-----QVVH RRLLQQQQGD DASSSSDSYY PIIIRGWIIK AED--PPGGG SDDFFEEVGD D-----LPPH RRLLEEEEGD DSSSSSDSYY -LLLIREGGV MLVTTVVNNG KNNFLDDFGK KPLLGGAAAH RRYYPPPPGD DCSSSSDIWW -LLLIREGGV MLITTAANNG KNNFLDDFGK KPLLGGAAAH RRYYPPPPGD DCSSSSDIWW -LLLIREGGV MLITTVVKKG KNNFLDDFGK KPLLGGAAAH RRYYPPPPGD DCSSSSDIWW -LLLIREGGV MLITTVVKKG TNNFLDDFGK KPLLGGAAAH RRYYPPPPGD DCSSSSDIWW -LLLIREGGV MLVTTVVKKG KNNFLDDFGK KPLLGGAAAH RRYYPPPPGD DCSSSSDIWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -LLLIREGGV MLVTTVVKKG KNNFLDDFGK KPLLGGAAAH RRYYPPPPGD DCSSSSDIWW -LLLIREGGV MLITTVVKKG KNNFLDDFGK KPLLGGAAAH RRYYPPPPGD DCTTSSDIWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMMIKEGGV MLITTEEKKG KNNFLDDFGK KPGGGGVAAH RRYYPPPPGD DCSSSSDIWW -LLLLKEGGV MLITTKKKKG KNNFLDDFGK KPDDGGVAAH RRYYPPPPGD DCTTSSDIWW -LLLVEKGGH ILITTEEKKG KNNFFDDFGA APDDGGAAAH RRYYPPPPGD DCTTSSDIWW -LLLVEQGGH ILITTEENNG KNNFFDDFGA APDDGGSAAH RRYYPPPPGD DCTTSSDIWW -LLLMDKGGH IIITTEEKKG SNNFFDDFGD DPEEGGAAAH RRYYPPPPGD DCTTSSDIWW -IIIMEKGGH IIITTEEKKG TNNFFDDFGD DPDDGGSAAH RRYYPPPPGD DCTTSSDIWW GLLLVKKGGH MLITTEEKKG SNNFFDDFGA APEEGGSAAH RRYYPPPPGD DCTTSSDIWW -HHHVKSGGT MVVPPEESSK ENNFLDDFGK KEGGGGYAAH RRYYPPPPGD DCTTSSDIWW -NNNVRSGGT MLIPPIITTH VNNFLDDFGK KPGGGGYAAH RRYYPPPPGD DCTTSSDIWW -VVVVKEGGV MLITTEEKKG TNNFLDDFGK KPNNGGCAAH RRFFPPPPCD DSTTSSDILL -MMMVAAGGT IVLVVEENNG KNNFLDDFGG GPYYGGGPPH RR-------- ---------- -MMMVSQGGH IVITTVVNNG SNNFLDDFAN NPYYGGSPPH RRYYPPPPGD DCTTSSDIWW ---------- ---------- ---------- ---------- ---------- ---------- -----KKGGD DAYYYNNWWG EVVFADDFYE EGLLGG-AAH RRFFGGGGSA ALYYSSS--- -----KKGGD DEFYYYYWWG EKKFADDFYA AKLLGG-PPH RRFFGGGGAA ALYYAAGPAA Y------ F------ FSK---- FS----- FS----- Y------ Y------ YS----- W------ W------ W------ W------ W------ ------- ------- W------ W------ ------- ------- ------- W------ W------ W------ W------ W------ W------ W------ W------ W------ L------ ------- WD----- ------- ------- ANLQARE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNNSKAKKQS EATPPRRTTA APPTTGGTRR RLADGAAQSP RQLLLLLSSL LTPPSPPVVR gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IAAAAYYEEA AWTFIIVASR SESRRKTSPP PGLVEISAAA AAQVVQAQQW HWLLPPKAVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----AEAFTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MGLLGKETAA ---------- ---------- ---------- ---------- ---------L KNSSQGLQTT ---------- ---------- ---------- ---------- ---------- ---------- -----MMGGR SAPTLLNTPH PNPPPASPPP PRVPLTLVVV PPRIIPPPPC PHAARHLHII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMKRE--- ---------- ---------- ---------- ---------- ---------- --MMKRIPSS ---------- ----MAVVPF FKPPKKMMMK AAAPPELAAY VCTTGGGGIN RRRAADFVDV ---------- ------AAKL LKPPRRDMMR AAAPPEIAAY VAVVGGGGVN AAAPPDFVDV ---------- ------MMSM MRPPEELMMQ AAAPPEFAAY TLPPDDSS-- RRRPPDAVDV ---------- ------MMTM MRPPKKLMME AAAPPEFAAY TLPPDDSS-- KKKPPDAVDV ---------- ------MMTL LRPAKKLMME GGGPPELAAF TMPPDDSS-- KKKPPDGVDV ---------- ------AATW WKPPRRLAAK AAAPPEIAAY VMPPEEKK-- QQQPPDAVDV ---------- ------VVTW WRPPRRMVVK AAAPPELAAY VRPPMMNNG- KKKPPDAVDV ---------- ------AASW WRPPKKMMMQ AAAPPELGGY VLPPGGEE-- RRRPPDAVDL ---------- --AATKTTK- --PLEEAKK- GGGPPEIVVY LCRRNNGGTE AAAPPDYTDV ---------- ---------- -------MM- GGGPPEIVVY LCRRNNGGIE AAAPPDYTDV IIPPAGLLPP --SSTQGGK- --PLEEAKK- GGGPPEIVVY LCGGNNGGIE AAAPPDYTDI ---------- ---------- -------KK- GGGPPEIIIY LCRRNNGGIE AAAPPDYTDV ---------- --AATKGGN- --PLEEAKK- GGGPPEIVVY LCRRNNGGTE AAAPPDYTDV QQVVAPMRPP AAAATKGGN- --PLEEAKK- GGGPPEIVVY LCRRNNGGTE AAAPPDYTDV ---------- --AATKGGN- --PLEEAKK- GGG------- --------TE AAAPPDYTDV ---------- --AATKGGN- --PLEEAKK- GGGPPEIVVY LCRRNNGGTE AAAPPDYTDV PPFFLGQLWW EEAATKGGD- --PQEEAKK- GGGPPEIVVY LCRRNNGGTE AAAPPDYTDV TTLLHYCTLL FFPPTKGGN- --PLEEAKK- GGGPPEIVVY LCRRNNGGTE AAAPPDYTDV ---------- --AATKGGN- --PLEEAKK- GGGPPEIVVY LCRRNNGGTE AAAPPDYTDV EEAAAVETAA AAGGKTCCHT TAPLEEAEEK GGGPPELVVY VCNNGGGGIN KKKLLDYTDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMAKGGS- --PLDDAKK- GGGPPEIVVY LCRRSSGGIN KKKPPDYTDV AAVVLHGVVV EESS-VGGCC CKPIEESSS- GGGPPELIIY VAAAGGGGIE KKKPPDYTDV GGVVLHAVVV EENNNQGGCC CKPLEEASS- GGGPPELIIY VAAAGGGGIE KKKPPDYTDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMLQ QVPLAAASS- GGGPPELIIY VATTGGGGID KKKPPDYTDV -------MAA AAGGAACCGG GAPLEEAEEK GGGPPELLLY VCNNGGGGIN KKKPPDYTDV --------MM PPGGLKHHG- --PADDAKK- GGGPPEVLLF VA----AAAD GGGPPDATDV --------MM --PPLKHHG- --PADDAKK- GGGPPEVLLF VA----AARD GGGPPDATNV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MSSSKC CKPLDDARRN GGGPPELLLY VCPPNNDDEE HHHGGDYTDV ---------- ---------- -------RRS GGGPPELLLY TTPPNNDDEP HHHGGDYTDV ---------- ---------- --P-DDIIIS LLLDDRLYYF SWGGDDRRQY DDDIITDNRM -----ALAAA --AAMGPPFR RADPYYMKKI TTTGGEFVVY VTVVEEMMGD EEEQQDKTDL HHAALALVSS LLAALAPPAG GVDPYYMKKI TTTGGEYVVY VTAAEEVVGD EEEQQDKTDA VVPPKETTYS KVHVLLLPPP YYIDEELHHH WAACCCSSLC CCCC-GGNNI IELLGGLLRS VVPPKPTTYG KIYLLLLPPP YYIDEELHHH WAACCCSSYC CCCC-AAFFL LELLAALLRS VVPPGSTTYG KVHVMMMPPP NNTDEEFHHH WAACCCSSLS SSSS-TTFFL LELLGGLLRS VVPPGPTTYG QVHVMMMPPP NNKDEEFHHH WAACCCSSLS SSSS-AAFFI IELLGGLLRS VVPPTEKKFG QVHLMMMPPP NNKDEEFHHH WAACCCSSLS SSSS-TTFFL LELLGGIIRS VVPPAPRRYA SVGVMMMPPP HHADEELHHH WAACCCSSLC CCCC-AAHHM MELLGGLLRS VVSSQSTTFG QVGTMMMPPP YYTGEELHHH WAACCCSSLC CCCC-AAHHV VELLDDIIRS LLPPDGTTYA QVGVMMMPPP NNADEELHHH WAACCCSALC CCCC-AAHHV VELLGGIIRS VVPPKPQQYS QIHLMMMPPP YYLDEELHHH WTTCCCSS-- -----FFTTK KSLLGGLLMS VVPPKPHHYS QIHLMMMPPP HHLDEELHHH WTTCCCSS-- -----FFTTK KSLLSSIIIS IIPPKPQQYC QIHLMMMPPP NNLDEELHHH WAACCCSS-- -----FFTTK KSLLCCLLMS VVPPKPQQYC QIHLMMMPPP HHLDEELHHH WTTCCCSS-- -----YYTTK KALLAALLIS VVPPKPQQYC QIHLMMMPPP NNLDEELHHH WTTCCCSS-- -----FFTTK KSLLSSLLIS VVPPKPQQYC QIE------- ---------- ---------- ---------- ---------- VVPPKPQQYC QIHLMMMPPP NNLDEELHHH WTTCCCSS-- -----FFTTK KSLLSSLLIS VVPPKPQQYC QIHLMMMPPP NNLDEELHHH WTTCCCSS-- -----FFTTK KSLLSSLLIS VVPPKPQQYS QIHLMMMPPP YYLDEELHHH WTTCCCSS-- -----FFTTK KSLLSSFFIS VVPPKPQQYC QIHLMMMPPP NNLDEELHHH WTTCCCSS-- -----FFTTK KSLLSSLL-- VVPPKPQQYC QIHLMMMPPP NNLDEELHHH WTTCCCSS-- -----FFTTK KSLLSSLLIS LLPPSPTTYS QIHLVVVIII HHIDKKLHHH WSSCCCSS-- -----HHSSA AKLLSSLLLS ---------- ----MMMPPP NNTDEELHHH WTTCCCSS-- -----YYSSK KVLLCCLLIS VVPPKPSSYS QIHLMMMPPP NNVDEELHHH WTTCCCSS-- -----YYSSK KVLLCCLLIS VVPPSPTTYS KIHLVVVPPP YYVDEELHHH WSSCCCSS-- -----HHSSA AELLSSLLVS LLPPNPTTYS KIHLVVVPPP YYVDEELHHH WSSCCCSS-- -----HHSSA AQLLGGIIVS ---------- ----MMMPPP FFVDEELHHH WSSCCCSS-- -----HHSSA ADLLSSLLIS VVPPSPSSYS SIHLMMMPPP FFVDEELHHH WSSCCCSS-- -----HHSSV VDLLSSLLIS VVPPNPTTYS QIHLVVVTTT HHVDEELHHH WAACCCSS-- -----HHSSA ASLLSSLLLS VVPPEDTTFC QISVVVVPPP HHIDEEVHHH WAACCCSS-- -----HHTTE EKLLCCLLNS VVPPEETTFC QISVVVVPPP NNIDEEVHHH WAACCCSS-- -----HHTTE EKLLCCLLNS ---------- ---------- ---------- ---------- ---------- --MMKKLLSS VVPPAPTTYC QIHTTTTNNN SSKNEELHHH WTTCCCSSHF FFFFVGGVVP PTLLCCLLNS VVPPEPTTYC QVHTTTTNNN RRKDEELHHH WAACCCSSYY YYYYVSSVVP PKLLSSLLNS MMGGQFLLGG SLKGVVVKKK VVLDKKELLL PPPRRRIL-- -------VVQ QGMMSSLLDG LLPPGATTRG QINVVVVGGG GG-NEEAHHH FAA------- ---------- -DFFGGLLDT AAPPKPQQYG KVNLVVVGGG GG-NEEAHHH FDD------- ---------- -DLLGGLLDT SSYIIIITKP PPNNPPEKII KVVVIEPPPE KKKVSSSSGG YSLLTTVVHH HHCGDDDDDD SSYIIIVTKP PPDDKKRAVV KIIIVEPPPV VGGRTTTTGG YTYYTTVVHH HHCGDDDDDD SSYVVVITKP PPHHPPQRII KIIIIEPPPE LAAKTTTTGG YSPPTTVVHH HHCGEEEEEE SSYIIIITKP PPDDPPKKII KIIIIEPPPE FKKKTTTTGG YSPPTTIIHH HHCGDDDDDD SSYIIIVVK- --EEPPKKII KIIIIEPPPE FAAKTTTTGG YSPPTTIIHH HHCGEEEEEE SSYIIILTKP PPDDPPKFLL KVVVIEPPPT AEERTTTTGG YSPPTTVVHH HHCGGGGGGG SSTIIILTKP PPDDPPQKVV KVVVIDPPPE AEERTTTTGG YAPPTTVVHH HHCGDDDDDD SSHIIIVTKP PPDDPPERII KVVVIEPPPE HRRRTTTTGG YSPPTTIIHH HHCGDDDDDD SSYVVVVVGS SSEEPPAKLL KVVVIEAAAE QAAKCCCCNN VSTTTTSSHH HHCLSSSSSS SSYVVVVVGS SSEEPPAKLL KVVVIEPPPE HAAKCCCCNN LGLLTTSSHH HHCLSSSSSS SSYVVVVVGS SSDDPPAKLL KVVVIEAAAD HAAKCCCCGG LGVVTTSSHH HHCLSSSSSS SSYVVVVVGT TTEEPPAKLL KVVVIEPPPD HTTKCCCCNN LGFFTTSSHH HHCLSSSSSS SSYVVVVVGS SSEEPPAKLL KVVVIEPPPD HAAKCCCCEE LALLTTSSHH HHCLSSSSSS ---------- ---------- ------PPPD HAAKCCCCEE LALLTTSSHH HHCLSSSSSS SSYVVVVVGS SSEEPPAKLL KVVVIEPPPD HAAKCCCCEE LALLTTSSHH HHCLSSSSSS SSYVVVVVGS SSEEPPAKLL KVVVIEPPPD HAAKCCCCEE LALLTTSSHH HHCLSSSSSS SSYVVVVVGT TTEEPPAKLL KVVVIEAAAD HEEKCCCCGG LGPPTTSSHH HHCLTTTTTT ---------- ---------- ---------- ---------- ---------- ---------- SSYVVVVVGS SSEEPPAKLL KVVVIEPPPD HAAKCCCCEE LALLTTSSHH HHCLSSSSSS SGYVVVVTAT TTDDPPTSLL KVVVVESSSD AEENIIIIGG LGPPTTSSHH HHCLSSSSSS SSYVVVVVGT TTDDPPARII KTTTVEPPPE FWWKCCCCGG LALLTTSSHH HHCLCCCCCC SSYVVVVVGS SSDDPPARII KTTTVEPPPE FWWKCCCCGG LAPPTTSSHH HHCLCCCCCC SGYVVVITKT TTNNPPSSLL KVVVVDPPPD IQQKTTTTGG LAPPTTSSHH HHCLSSSSSS SGYVVVITKT TTNNPPASLL KVVVVEPPPD STTKTTTTGG LAPPTTSSHH HHCLSSSSSS SGYAAAITKE EENNPPASLL KYYYVDPPPE AEEKTTTTGG LAPPTTAAHH HHCLSSSSSS SGYAAAITKE EENNPPASLL KYYYVDPPPE ADDKTTTTGG LAPPTTAAHH HHCR------ SGYVVVVTLK KKDDPPAALL KVVVVEAAAD AEEKTTTTGG LGPPTTSSHH HHCLSSSSSS SDYIIIIVEN NNEE--KYLL HTTTIEPPPK HSSLNNNN-- LSPPTTSSHH HHCLDDDDDD SDYVVVIVEN NNEE--EYLL HTTTIEPPPK HAALNNNN-- LSPPTTSSHH HHCLDDDDDD SGGKKKVVGG GG-------- ---------- ---------- ---------- ---------- SDFVVVITGT TTDDPPAKLL KVVVIEGGGD LKKGAAAADD CTPPTTTTHH HHCLNNNNNN SDYIIILVVT TTDDPPKEII KTTTIDGGGD LKKSHHHHNN VTPPTTTTHH HHCLNNNNNN GKYVVVTSLY YYSSAADQFF P--------D IKKFLLLLVV LASSTTAADD DDYQNNNNNN TNFIIIFVHS SSDDPPNKLL KTTTIDTTTF KDDSGGGGGG VVPPTTFFFF FFALGGGGGG TSFVVVFVHS SSDDPPRVLL KTTTITDDDF EKKSGGGGGG VVPPTTLLYY YYALGGGGGG AIISAAGEEG --EGGGGLMM LLDYYEPLEI DGDD------ -----LAYYY DDDDFFWWNL AIISAAGDDG RREGGGGFLL LLDDDEPIEV YGPP------ -----FAYYY DDDDFFWWNL GIVSTTGDDG TTDGPPGFII MMDEEDVLEI DGPP------ -----KHYYY DDDDFFWWNL GIVSTTGDDG TTNGPPGFII MMDEEEVLEI DGPP------ -----LHYYY DDDDFFWWNL GIVSTTGDDG TTDGPPGFII LLDEEEILEM DGEE------ -----KHYYY DDDDFFWWNL GIVTAAGEEG --KGGGGAMM LLDQQEPLEV EGPP------ -----FAYYY DDDDGGWWHL GIISAAGEEG --EGGGGFII LLDDDEVLEI DGDD------ -----LHYYY DDDDFFWWHL GVVSAAGEEG --DGGGGFVV MMDEEDPLEV EGPP------ -----LAYYY DDDDFFWWHL GEMVNNLLLQ GGNGGGSVLL LLDEEEVKEK PGAA------ -----MGYYY DDDDFFWWQP GEMISSLPPQ GGNGGGGVLL LLDEEEVKEK PGEE------ -----MGYYY DDDDFFWWQP GEMISSLSSK GGNGGGGVLL LLDEEEVKEQ PGAA------ -----MGYYY DDDDFFWWQP GEMVSSLPPE GGNGGGGVLL LLDKKEVKEQ PGAA------ -----LGYYY DDDDFFWWQP GEMISSLVVK GGNGGGGVLL LLDEEEVKER PGAA------ -----SGYYY DDDDFFWWQP GEMISSLVVK GGNGGGGVLL LLDEEEVKER PGAA------ -----LGYYY DDDDFFWWQP GEMISSLVVK GGNGGGGVLL LLDEEEVKER PGAA------ -----LGYYY DDDDFFWWQP GEMISSLVVK GGNGGGGVLL LLDEEEVKER PGAA------ -----LGYYY DDDDFFWWQP GEMISSLPPK GGNGGGGVLL LLDEEEVKER PGSS------ -----MGYYY DDDDFFWWQP ---------- ---------- ---------- ---------- ---------- ---------- GEMISSLVVK GGNGDDGLVV LLL--ECS-- ---------- ---------- ---------- GDMISSLKKE GGNAGGNFLL LLLSSNVKSN RFPP------ -----KERRR TTTTHHLLEN GEMISSIPPY GGNGGGGVLL LLDEEEVKEA EEAA------ -----FGYYY DDDDFFWWQP GEMISSLPPC GGNGGGGVLL LLDEEEVKEV EESS------ -----FGYYY DDDDFFWWQP GEMISSLKKD GGNAGGNFLL LLLSSNVKEK PHSS------ -----FGYYY DDDDFFWWQP GEMISSIKKD GGNAGGNFLL LLLSSNVKEK PHSS------ -----FGYYY DDDDFFWWQP GELVSSLEEE GGNAGGNFLL LLLSSNIKEK PHSS------ -----FGYYY DDDDFFWWQP GELVSSLEEE GGNAGGNLLL LLLSSNIKEK PISS------ -----YGYYY HHHHFFWWQP GEMISSLKKE GGNAGGNFLL LLLSSNVKEK PHSS------ -----FGYYY DDDDYYWWQP GNMISSLAAN GGTPGGNLLL LLDKKEPKPA DKTT------ -----FNYYY DDDDFFWWQP GNMISSLAAD GGSPGGNLLL LLDKKEPKPA DKVV------ -----FNYYY DDDDFFWWQP ---------- ---------- ---------- ---------- ---------- ---------- GNMISSMAAE GGNAGG-FVV EEFKKELVSR GRKK------ -----CGYYY DDDDYYWWQP GNMISSMAAE GGYAGG-FII LLFSSNCITK GKKK------ -----CGYYY DDDDFFWWQP TAKQDDVSSL SSVPLLNIQQ TTSHHGLSEA SFEE------ -----LQLLL SSSSNNHHNG SMITGGSDDD HHGGTTAVEE YYNDDYVAMP TDDDGAAAGG DDADGYGYYY DDDDIIRRLI RMITGGSKKD HHGGTTAVEE YYTAAYVAIP TGDDGAAAGG --KDGYDYYY DDDDVVRRLP --PNEEVSSW WAAVPPPP-- TEEEDD-LLL EHKRRYNRIH HWDLRRRRKR RRISSSLLLL --PSGGVTSW WTTVPPPP-- CEEEEE-LLL ECKAAYNKLH HWDLAAAAKR RHLAAAIIII --PRDDYSSW WAALPPPP-- QEEENN-PPP EDLKKYHRLH HWDLRRRRAR RNVTTTIIII --PRDDYTSW WAALPPPP-- QEEENN-PPP EDLKKYHRLH HWDLRRRRAR RNVTTTIIII --PRDDYSSW WGGLPPPP-- QEEENN-PPP EDLKKYHKIH HWKLRRRRDR RNVTTTIIII --GYDDTTSW WGGTPPPP-- MEEEDD-PPP DILRRYRRLH HWDLTTTTRR RHLEEEIIII --GYDDTTSW WGGTPPPP-- MEEESS-GGG DELKKYHRLH HWDLYYYYRR RHLTTTLLLL --GYDDTTSW WGGTPPPP-- MEEEGG-PPP QILGGYRRLH HWDLRRRRRR RHLAAALLLL --RHNNVSTW WAAAPPPP-- VKKKDDFAAA HVALLYSRIF FWDWQQQQRH HIITTTLLLL --RHNNISTW WAAAPPPP-- VKKKDDFAAA HVALLYSHIH HWDWQQQQRH HIITTTLLLL --RHNNVSTW WAAAPPPP-- VRRRDDFAAA DVALLYSHLH HWDWQQQQRH HIITTTLLLL --RHNNVSTW WAAAPPPP-- VRRRDDFAAA DVALLYSHLY YWDWQQQQRR RIVTTTLLLL --RHNNVSTW WAAAPPPP-- VRRRDDFAAA DVALLYSHLY YWDWQQQQHH HIVTTTLLLL --RHNNVSTW WAAAPPPP-- VRRRDDFAAA DVALLYSHLY YWDWQQQQRH HIVTTTLLLL --RHNNVSTW WAAAPPPP-- VRRRDDFAAA DVALLYSHLY YWDWQQQQRH HIVTTTLLLL --RHNNVSTW WAAAPPPP-- VRRRDDFAAA DVALLYSHLY YWDWQQQQRH HIVTTTLLLL --RHNNVSTW WAAAPPPP-- VQQQNNFAAA DVALLYKHLH HWDWQQQQRH HIVTTTLLLL ---------- ---------- ---------- ---------- ---------- ---------- --------AS SAAHSSSS-- LLLLTTSYYY PAARRVGIT- ---------- ---------- YYAWGGLSWQ QCCCSSSS-- FTTTTTAMMM CLAGGVVISC CDNYIIIIMR RIDSSSLLLL --RHNNVSTW WGGAPPPP-- AAAALLFEEE EVAMMYHSLN NWDWTTTTEH HRITTTIIII --RHNNVSTW WGGAPPPP-- AAAALLFEEE DVAHHYHSLN NWDWTTTTEH HLVTTTIIII --RHNNTSTW WGGAPPPP-- ATTTKKFQQQ HVDLLYRHLT TIQLAAAARG GLRTTTLLLL --RHNNTSTW WGGAPPPP-- ALLLQQFQQQ HVDLLYRHLH HYSWPPPPGG GIKTTTLLLL --RHKKTSTW WGGAPPPP-- ASSSKKFQQQ HVDLLYSHLH HYSWPPPPGG GMKLLLIIII --RHKKTSTW WGGAPPPP-- ASSSKKFQQQ HVDLLYSHLH HYSWPPPPGG GIKLLLIIII --RHKKTSSW WGGAPPPP-- ARRRTTFQQQ HVDLLYRHLH HYDWPPPPGG GLKTTTLLLL --RRNNVSTW WGGSPPPP-- HKKKKKFAAA HVELLYNSVH HFEWDDDDSK KYLTTTIIII --RRNNISTW WGGSPPPP-- HKKKKKFAAA HVELLYNSVH HFEWDDDDTK KHLTTTIIII -------SIR RGGGPPPP-- TCCCRREKKK CQELLVKCKR RY-------- ---------- --HFNNVASW WGGAPPPP-- LRRRRRYTTT DCDQQYCRLN NYRWQQQQER RLFTTTIIII --YFDDVSSW WGGAPPPP-- KRRRRRWVVV DLDQQYCRLN NYKWSSSSTQ QLYTTTIIII ---REEKSDP PDDEPPPP-- MFFFEESFFF LKTLLKQHVA AVL------- ---------- --RKNNVTSF FTTGWWWWYY MDDDFFQQQQ DAARRFNTIV VWDLHHHHTR RPKVVVFFFF --RKNNLTSF FTTGWWWWYY MDDDFFKAAA DPAHHFNTVV VWDLHHHHTK KPKVVVFFFF TTGELL---- --LPPKKLLM FINMMVVKDL SIWLFFFGGK KKWKVVIEEE IIIIPELLEN DDGQLL---- --LPPKKLLM FVNVVVVKDL SIWLFFFGGK KKWRVVIDDD IIIIEQFFEP DDGALL---- --APPRREEY FVGVVVVTNL EIWTWWWGGK KKFKTTATTT IIIIPEAATE DDGALL---- --APPRREEY FVGVVVVTNL EIWTWWWGGK KKFKTTATTT IIIIPEAAPK DDGALL---- --APPKKDDY FCGVVVVTNL QIFTWWWGGT TTFKTTITTT IIIIDVAADD DDGDFF---- --APPKKAAY FVNCCVVKDL SIWTYYYDDK KKWKVVIEEE IIIIPEAADQ DDGALL---- --APPKKAAY FMNCCVVKDL SIWLYYYGGS SSWKVVIDDD IIIIPEAASQ DDGELL---- --APPRRTTY FVGVVVVEDL SVWLHHHGGS SSWKVVIEEE IIIIPEAAEQ QQT-PP---- -LLPPAATTQ FVGCCAANIQ RKNEGGG--- ------TWWW SSSSVKIIQS QQK-PP---- -LLPPAATTQ FVGCCAANIQ RKNEGGG--- ------TWWW SSSSVKIIQS TTQ-PP---- -LLPPAAAAQ FVGCCAATIQ RKNQGGG--- ------TWWW SSSSVKIIQP PPQ-PP---- -LLPPAAAAQ FVGCCAATIQ RKNEGGG--- ------TWWW SSSSAKIIQP SSK-PP---- -LLPPAAAAQ FVGCCAATIQ RKNEGGG--- ------TWWW SSSSVKIIQP SSK-PP---- -LLPPAAAAQ FVGCCAATIQ RKNEGGG--- ------TWWW SSSSVKIIQP SSK-PP---- -LLPPAAAAQ FVGCCAATIQ RKNEGGG--- ------TWWW SSSSVKIIQP SSK-PP---- -LLPPAAAAQ FVGCCAATIQ RKNEGGG--- ------TWWW SSSSVKIIQP LLP-PP---- -LLPPAASSQ FVGCCAATIQ RKNEGGG--- ------TWWW SSSSVKIIEP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPQ-AANNPP PLIKKIINNQ YDVVVEESGR GDPDYYY--- ------AVVV VVVVLRLLDY DDGEPP---- -LLPPAAAAQ LVGCCAATVF RKEKGGG--- ------KWWW AAAAAKIIKS DDGKPP---- -LLPPAADDQ LVGCCAASIF RKEKGGG--- ------KWWW AAAAAKIIQS DDGNPP---- -LLPPKKDDT FVGSSAANMI RKTQGGG--- ------SWWW SSSSHLIIPP DDGDPP---- -LLPPKKDDT FVGSSAANMI RKTQGGG--- ------SWWW NNNNHIIISP DDGEPP---- -LLPPKKDDT YVGSSAANMI RKNSDDD--- ------TWWW SSSSYIIISP DDGPPP---- -LLPPKKDDT FVGSSAANMI RKNSEEE--- ------TWWW SSSSHVIISP DDGSPP---- -LLPPKKDDT YVGCCAANMV RKTAGGG--- ------SWWW SSSSHVIISP DDPQPP---- -LLPPSSEEH FVGCCAAGIF RPVENNN--- ---T--THHH AAAAALAAFS DDPMPP---- -LLPPSSEEH FVGCCAAAIF RPDENNN--- ---K--VQQQ TTTTALAATS ---------- ---------- ---------- ---------- ---------- ---------- DDGDPP---- -LLPPEENNQ YVGCCAAXXX X--------- ---------- ---------- DDGSPP---- -LLPPKKAAE FVGCCAAKVF HKKSSSS--- ---EFFEAAA KKKKKIIIPL ---------- ---------- ---------- ---------- ---------- ---------- NNPG------ -LPSSAANNY FSTTTAAQLW LEDDGGG--- ---------- --------EA DDPG------ -LAEEHHNNY FTSTTAAQLW LEDGGGG--- ---------- --------EA NNNLPPILKF KAAAVVTTSS SSLDDDFYWW WGGIGVQYIN NPFKKLGGVK GGIFHRHPP- PPPLPPVLKF KMMMVVTTSS SSLDDDFYWW WGGLGLQYIN NPHQQLGGVK GGLYHRHPP- EEELPPLLQF GAAAVVTTSS SSLDDDFYWW WGGTGMQYVD DPHNNLGGVR GGIARRHPP- KKKLPPLLQF GAAAVVTTSS SSMDDDFYWW WGGTGMQYVD DPRKKLGGVH GGIARRHPP- DDDLPPLLKF GAAACVTTSS SSLDDDYYWW WGGLGMQYVD DPMNNLGGVE GGIVKKHPP- QQQLPPVLKF KAAAVVTTSS SSMDDDFYWW WGGTGLQYVD DPFEELGGVR GGIVSRHPPG QQQLPPILKF KAAAVVTTSS SSVDDDFYWW WGGTGLQYVD DPFNNLGGVQ GGIVRRHPP- QQQLPPLLKF GAAAVVTTSS SSLDDDFYWW WGGTGLQYVD DPFNNHGGVR GGIVRKHPP- SSSKKKKGWL PEEEMITTSS SSLDDDFYWW WLLHGIQYIN NPQKKLGGIF GGSIVRSVVQ SSSKKKKGWL PEEEMITTSS SSLDDDFYWW WLLHGIQYIN NPKKKLGGIF GGSIVKSVVQ PPPKKKKGWL PEEEMITTSS SSLDDDFYWW WLLHGLQYID DPQRRLGGLF GGSIVKPVVQ PPPKKKKGWL PEEEMITTSS SSLDDDFYWW WLLHGIQYVD DPQRRLGGLF GGSIVKPVVQ PPPKKKKGWL PEEEMITTSS SSLDDDFYWW WLLHGLQYID DPQRRLGGLF GGSIVKPVVQ PPPKKKKGWL PEEEMITTSS SSLDDDFYWW WLLHGLQYID DPQRRL---- ---------- PPPKKKKGWL PEEEMITT-- ---------- ---------- ---------- ---------- PPPKKKKGWL PEEEMITTSS SSLDDDFYWW WLLHGLQYID DPQRRLGGLF GGSIVKPVVQ PPPKKKKGWL PEEEMITTSS SSLDDDFYWW WLLHGMQYID DPKRRLGGIF GGSIVKPVVQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYYAVVAKFV VSSSLFPPFF FFFSDDLI-- ---------- ---------- ---------- SSSKKKEGWL PEEEMITTSS SSLDDDFYWW WLLHGIQYID DPRNNLGGIF GGSILRPVVT SSSKKKEGWM PEEEMITTSS SSLDDDFYWW WLLHGIQYID DTRNNLGGIF GGSIQRPVVT PPPLKKQNWL PEEEMITTSS SSLDDDFYWW WLLHGIQYID DLKNNLGGLW GGLIQKPVVA PPPLKKQNWL PEEEMITTSS SSLDDDFYWW WLLHGIQYID DVKNNLGGVW GGLIQKPVVV PPPLKKENWL PEEEMITTSS SSLDDDFYWW WLLHGIQYID DPKNNLGGIW GGLLQKPVVK PPPLKKENWL PEEEMITTSS SSLDDDFYWW WLLHGIQYID DPKNNLGGIW GGLLQKPVVK PPPLKKRNWL PEEEMITTSS SSLDDDYYWW WLLHGIQYID DPAKKLGGVW GGLLQKEVVV SSSKKKSGWL PEEEMITTSS SSMDDDFYWW WLLHGIQYID DPLKKLSSVY GGSVHTNVVK SSSKKKENWL PDDDMITTSS SSMDDDFYWW WLLHGIQYID DPKNNLSSVF GGSIHSTVVK ---------- ---------- ---------- ---------- ---------- ---------- ----QQENGI EMMMMMTTSS SSLDDDYYWW WRRHGVQYID DRANNLGGVF GGAIQRPRRR LLLVDDGSGA EDDDMISSSS SSLDDDFYWW WRRHGVQYID DPENNLGGLF GGAICSPNNV ---------- ---------- ---------- ---------- ---------- ---------- AAAKAAADIN PAAADPVVAA AAADDDTWFF FMMDGTLFID DPHKKQYYKV DDQVN----- AAAKAAADIE PAAAKPVVSS SSNDDDRWFF FMMDGTLFID DPHHHQYYKT GGQVN----- ---------- ---------- AGGHLTGGAM ISRRDGRVVN NYYTTWDDNN FFFFYPPEEE ---------- ---------- SGGAATGGAM VSRRDGRVIN NYYSSWNNNN FFFFYPP--- ---------- ---------- NGGRFAGGGM ISRRDGRVWN NYYTTWDDDD FFFFYPPDDD ---------- ---------- NGGKFAAAGM ISRRDGRVWN NYYTTWDDDD FFFFYPPDDD ---------- ---------- NGGKFGYYGM ISRRDGRVWN NYYTTWDDEE FFFFYPPGGG G--------- -------AAA KNNGLNGGGM ISRRDGRVFN NYYAAVDDPP FFFFYPPEEE ---------- -------AAA TSSALNGGGM ISRRDGRVFN NYYAAWDDEE FFFFYPPDDD ---------- ---------- ASSGLNGGGM VSRRDGRVFN NYYSSWDDEE FFFFYPPVVV QVVEE-DQLP PEEELLVVVV KGGKIPGGGM LSLLDGRLAT TYYDDWDDKK FFFFY--PPP QVVEE-DQLP PEEELLVVVV KGGKVPGGGM LSLLDGRLVT TYYAAWDDKK FFFFY--PPP QVVEE-DQLP PEEELLVVVV KGGKVPGGGM LSLLDGRLVT TYYAAWDDKK FFFFY--PPP QVVDD-DQLP PEEELLVVVV KGGKVAGGGM LSLLDGRLVT TYYAAWDDKK FFFFY--PPP QVVEE-DQLP PEEELLVVVV KGGKVAGGGM LSLLDGRLIT TYYAAWDDKK FFFFY--PPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QVVEE-DELP PEEELLVVVV KGGKVAGGGM LSLLDGRLIT TYYAAWDDKK FFFFY--PPP QVVEE-DQLP PEEELLVVVV KGGKVPGGGM LSLLDGRIVT TYYDDWDDKK FFFFY--PPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TVVEE-DKLP PDDDVVIVVV KGGKVPGGGM LSLLDGRLVN NYYKKWDDKK FFFFY--PPP TVVEE-DKLP PDDDVVTVVV KGGKIPGGGM LSLLDGRIVS SYYIIWDDKK FFFFY--PPP AAAGG-EDKS SDDDPPEIII QGGQLRGGGM LTLLDGRLVN NFFAAWDDKK FFFFY--PPP VAAKK-DDES SDDDPPEIII QGGKLRGGGM LSLLDGRLVN NFFAAWDDKK FFFFY--PPP KAAGG-EDNF FDDDPPQIII KGGKLRGGGM LSLLDGRLAN NFFAAWDDRR FFFFY--PPP KAAGG-EDNF FEEEPPQIII KGGKLRGGGM LSLLDGRLAN NFFAAWVVVV FFFFY--PPP VYYTT-EDKY YSSSPPQVVV KGGHLRGGGM LSLLDGRIVN NFFRRWDDEE FFFFYGGQQQ KVVEE-GE-I IEEELLYVVV KGGRIEGGGM LSLLDGRLVT TYYKKWDDDD FFFFY--PPP KVVEE-EDDI IPPPLLYVVV KGGRIEGGGM LSLLDGRLVT TYYKKWDDDD FFFFY--PPP ---------- ---------- ------GGGK LSVVDGRLVN NYYTTWDDKK FFFFY--PPP RVVNN-DPLP PEEEVVFLLL KGGRLLGGGM LSLLDGRLVS SFFPPWDDKK FFFFY--PPP VIIKKEDKLP PPPPRRYVVV KGGRLEGGGM LSLLDGRLVS SYYPPWDDKK FFFFY--PPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M QSWWDGRVFS SLLNNWDD-- ---------- ---------- ---------- ---------M SSWWDGRLYS SLLNNWDD-- ---------- EGLLKKGGMM VKKLN----- SSGGLEIDDK FFFFE----- -ARSQVVRRR GAASSDDDYC -GLLRRGGMM AKKVN----- EEGGLELEEK FFFFR----- -ARAQVVRRR GAASTDDDFC DGVVPPAAQQ VLLAG----- DDGGLTLAAD YYWWD----- -YRAQIIRRR GCCSTDDDFC DGVVPPGGEE VMMAG----- NNGGLELDDK YYFFD----- -YRAQIIRRR GCCSTDDDFC GDRRGGAAMM VMMAG----- NNGGLTLDDK FFWWA----- -YRSQIIRRR GCCSTDDDFC EGIIDDGGMM VKKLG----- NNGGIEFDDP FFFFK----- -HRPQVVRRR GCCSSDDDYC DGIIKKGGMM VKKVN----- DDGGMQFDDP FFFFE----- -QRVQIIRRR GAASSDDDYC VGIIRRGGII AKKAD----- GGGGLSLDDP FFFFD----- -LRPQIIRRR GSSSSDDDYC PDLLIIRRGG SVVMVDVVVD NNGGLKLNNP FFLLKPPLLL GALAELLRRR GCCSSDDDWI PNLLIIRRGG SVVMIDVVVD NNGGLKLNNP FFLLKPPLLL GALAELLRRR GCCSSDDDWI PDLLIIRRGG SVVMIDVVVD KKGGLKLNNP FFLLKPPLLL GALAELLRRR GCCSSDDDWL PDLLIIRRGG SVVMIDVVVD KKGGLTLNNP FFLLKPPLLL GALAELLRRR GCCSSDDDWL PDLLIIRRGG SVVMVDVVVD KKGGLKLNNP FFLLKPPLLL GALAELLRRR GCCSSDDDWI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PDLLIIRRGG SVVMVDVVVD KKGGLKLNNP FFLLKPPLLL GALAELLRRR GCCSSDDDWI PDLLIIRRGG SVVMIDVVVD KKGGLKLNNP FFLLKPPLLL GALAEIIRRR GCCTSDDDWL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PDMMIIKKGG SVVMIDVVVD KKGGLKLNNP FFLLKPPGGG GVLAELLRRR GCCSSDDDWV PDLLLLKKGG AVVMIDVVVD KKGGLKLNNP FFLLKPPDDD GVLAEIIRRR GCCTSDDDWI PGLLVVEEGG SHHIIDVVVD KKGGLKINNP FFFFAPPDDD GALAEMMRRR GCCTSDDDWI PKLLVVEEGG SHHIIDVVVD NNGGLKINNP FFFFAPPDDD GSLAEMMRRR GCCTSDDDWI PELLMMDDGG SHHIIDVVVD KKGGLSINNP FFFFDPPEEE GALAEMMRRR GCCTSDDDWI PEIIMMEEGG SHHIIDGGGD KKGGLTINNP FFFFDPPDDD GSLAEMMRRR GCCTSDDDWI QDLLVVKKGG SHHMIDVVVD KKGGLSINNP FFFFAPPEEE GSLAEMMRRR GCCTSDDDWI PEHHVVKKGG ATTMVNIIID SSGKMEINNR FFLLKEEGGG GYLAEMMRRR GCCTSDDDWI PENNVVRRGG ATTMIDVVVD TTGHMVINNK FFLLKPPGGG GYLAEMMRRR GCCTSDDDWI PNVVVVKKGG SVVMIDVVVD KKGGLTVNNK FFLLKPPNNN GCLADIIRRR GSSTSDDDLA PEMMVVAAGG GTTILDIIID NNGGMKLNNE FFLLGPPYYY GGLPEMMRRR ---------- PKMMVVSSGG GHHIIDVVVD NNGGISLNNE FFLLNPPYYY GSLPEMMRRR GCCTSDDDWL ---------- ---------- ---------- ---------- ---------- ---------- ------KKGG KDDDYLKKKA WWDGKELVVE FFAAEGGLLL G-RAIMMRRR SLLYSSSS-- ------KKGG KDDDFLKKKL WWDGKELKKE FFAAAKKLLL G-RPQMMRRR RLLYAGGGAG CYYY--- CYYY--- CYYYV-- CYYYV-- CYYYV-- CYYY--- CFFF--- CYYY--- I------ I------ L------ L------ I------ ------- ------- I------ L------ ------- ------- ------- V------ I------ I------ I------ I------ I------ I------ I------ I------ A------ ------- LAAAA-- ------- ------- GDDDRAR 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NNNAAKKAKK QSSEEAATPA AVVPPTTTGL TTAAARLLDA AMMMQQSSSL LRTAAQLSLT gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVRIIKAAQ QEAAAAATSS AIIQSPRSKS SSSVVESSAA AKQQQSQAAQ QAAHLPGKHG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----ARAEG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MLGEEPG ---------- ---------- ---------- ---------- ---------- -LLKSQCLGF ---------- ---------- ---------- ---------- ---------- ---------- ---------A AGRSSSSPLP PLLNTPHPAP PPPHHLLLVV PYRRRVPRRP PPPPARSLVL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MKREFG ---------- ---------- ---------- ---------- ---------- ----MKFIVS ---------- ----AAAAII IVVPPFFRDP YPSSKKMMAM MKAAEEDAYY VACCLYYTTT ---------- --------MM MAAKKLLPDP YPTTRRDDAM MRAAEEDAYY VAAALYYVVV ---------- ---------- -MMSSMMPDP HASSEELLAM MQAAEEEAYY TLLLLSSPPP ---------- ---------- -MMTTMMPDP HASSKKLLAM MEAAEENAYY TLLLLSSPPP ---------- ---------- -MMTTLLPDP YPSSKKLLAM MEGGEEKAFF TLMMLSSPPP ---------- --------MM MAATTWWPDP YPSSRRLLAA AKAAEETAYY VAMMFDDPPP ---------- --------MM MVVTTWWPDP YPSSRRMMAV VKAAEEKAYY VVRRLNNPPP ---------- --------MM MAASSWWPDP YPSSKKMMAM MQAAEERGYY VALLLDDPPP ---------- ---AKKKKCC CTTKK--CGP PTPPEEAAMK K-GGEEEVYY LPCCIYYRRR ---------- ---------- ---------- ---------M M-GGEEEVYY LPCCIYYRRR AAAAVVAPRG LLGSQQQQCC CGGKK--CGP PSPPEEAAMK K-GGEEEVYY LPCCIYYGGG ---------- ---------- ---------- --------MK K-GGEEEIYY LPCCIYYRRR ---------- ---AKKKKCC CGGNN--CGP STPPEEAAMK K-GGEEEVYY LPCCIYYRRR AAAFTTSVQP MRIAKKKKCC CGGNN--CGP STPPEEAAMK K-GGEEEVYY LPCCIYYRRR ---------- ---AKKKKCC CGGNN--CGP STPPEEAAMK K-GG------ ---------- ---------- ---AKKKKCC CGGNN--CGP STPPEEAAMK K-GGEEEVYY LPCCIYYRRR HHHTAAWFSG QLQAKKKKCC CGGDD--CGP PTPPEEAAMK K-GGEEEVYY LPCCIYYRRR DDDQTTELTY CTVPKKKKCC CGGNN--CGP STPPEEAAMK K-GGEEEVYY LPCCIYYRRR ---------- ---AKKKKCC CGGNN--CGP STPPEEAAMK K-GGEEEVYY LPCCIYYRRR QQQHIIGAAV ETAGTTTTCC CCCHHTTKGP ATPPEEAAME EKGGEEKVYY VTCCVYYNNN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MKKKKCC CGGSS--CGP KSPPDDAAMK K-GGEEEVYY LPCCIYYRRR ------TVDH GVNSVVVVNN NGGCCCCSGP ASPPEESSMS S-GGEESIYY VTAAVYYAAA ------TVQH AVSNQQQQQQ QGGCCCCSGP ASPPEEAAMS S-GGEETIYY VTAAVYYAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------RR RMMLLQQGGP ATPPAAAAMS S-GGEEKIYY VTAAVYYTTT ---------- -MAGAAAACC CCCGGGGTGP ATPPEEAAME EKGGEEKLYY VTCCVYYNNN ---------- --SGKKKKCC CHHGG---GP ASPPDDAAIK K-GGEEELFF VTAAP----- ---------- --PPKKKKCC CHHGG---GP ASPPDDAAIK K-GGEEELFF VTAAP----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----SSSSEE ESSKKCCCGP ATPPDDAAVR RNGGEEKLYY VVCCVQQPPP ---------- ---------- ---------- --------MR RSGGEEKLYY TVTTVQQPPP ---------- ---------- --------MP IT--DDIILI ISLLRRFYFF SNWWLHHGGG ---------A LAGAGGGGLL LPPFFRRFAD CQSSYYMMPK KITTEEEVYY VWTTLGGVVV GGGPSSFARA LVGAAAAAAA APPAAGGRAD CASSYYMMKK KITTEEDVYY VWTTLGGAAA GGTADDIAAV VDVVPKSTYS SKKVEEINDH HAACCSSAAC -NN-KKKKKP NIERRLLIVV GGTPDDLAAV VDVVPKSTYG GKKLDDIGDH HAACCSSAAC -NN-KKKKKP FLERRLLIVV DDFPDDLAAV VDVVPGSTYG GKTVTTTGDH HAACCSSSSS -LLGHHHHHA FLERRLLIII DDFPDDLAAV VDVVPGSTYG GQTVTTKGDH HAACCSSAAS -LLGHHHHHA FIERRLLIII DDAPDDLAAV VDVVPTSKFG GQQLIIKGDH HAACCSSAAS -LLGHHHHHA FLERRLLIII EERPDDIAAV VDVVPASRYA ASQVAAAGDH HAACCSSCCC -NNPHHHHHP HMERRLLVVV MMAPDDMCCV VDVVSQSTFG GQVTDDTGGH HAACCSSMMC -NNPHHHHHP HVERRLLVVV GGRPDDLGGV VDLLPDSTYA AQRVEEAADH HAACCSAAAC -YYPHHHHHP HVERRLLIVV NNTPDDLAAT TDVVPKSQYS SQRLPPLKDH HTTCCSSCC- ---GDDDDDS TKSRNLLILL NNTPDDLAAT TDVVPKSHYS SQRLPPLKDH HTTCCSSCC- ---GDDDDDS TKSRDLLILL NNTPDDLAAT TDIIPKSQYC CQRLPPLRDH HAACCSSCC- ---GDDDDDS TKSRTLLMLL NNTPDDLAAT TDVVPKSQYC CQRLPPLKDH HTTCCSSCC- ---GDDDDDI TKARTLLVLL NNTPDDLAAT TDVVPKSQYC CQRLPPLKDH HTTCCSSCC- ---GDDDDDS TKSRTLLVLL NNTPDDLAAT TDVVPKSQYC CQ-------- ---------- ---------- ---------- ---PDDLAAT TDVVPKSQYC CQRLPPLKDH HTTCCSSCC- ---GDDDDDS TKSRTLLVLL NNTPDDLAAT TDVVPKSQYC CQRLPPLKDH HTTCCSSCC- ---GDDDDDS TKSRTLLVLL NNTPDDLAAT TDVVPKSQYS SQRLPPLKDH HTTCCSSCC- ---GDDDDDS TKSRNLLVLL NNTPDDLAAT TDVVPKSQYC CQRLPPLKDH HTTCCSSCC- ---GDDDDDS TKSRTLLVLL NNTPDDLAAT TDVVPKSQYC CQRLPPLKDH HTTCCSSCC- ---GDDDDDS TKSRTLLVLL GGTLDDLAAT TDLLPSSTYS SQRLPPIGDH HSSCCSSCC- ---GDDDDDP SAKRRLLILL ---------- ---------- ------TNDH HTTCCSSCC- ---GDDDDDA SKVRNLLILL SSTPDDLAAT TDVVPKSSYS SQRLPPVNDH HTTCCSSCC- ---GDDDDDS SKVRNLLILL GGTPDDLAAT TDVVPSSTYS SKRLPPVGDH HSSCCSSCC- ---GDDDDDP SAERRLLIAA GGTPDDLAAT TDLLPNSTYS SKRLPPVGDH HSSCCSSCC- ---GDDDDDP SAQRRLLIVV ---------- ---------- ------VGDH HSSCCSSCC- ---GDDDDDA SADRRLLVLL GGTPDDLAAT TDVVPSSSYS SSRLPPVGDH HSSCCSSCC- ---GDDDDDA SVDRRLLVLL GGTPDDLGGT TDVVPNSTYS SQRLPPVGDH HAACCSSCC- ---GDDDDDP SASRRLLILL --NPDDIFFT TDVVPESTFC CQRVDDIGDH HAACCSSCC- ---DKKKKKP TEKRSLLIVV --HPDDIFFT TNVVPESTFC CQRVDDIGDH HAACCSSCC- ---DKKKKKP TEKRSLLIVV ---------- ---------- ---------- ---------- ---------- -----MMVPP NNLGDDLAAT TDVVPASTYC CQRTYYKHNH HTTCCSSCCF V--GKKKKKE VPTRDLLVLL NNLGDDLSST TDVVPESTYC CQRTFFKGDH HAACCSSCCY VEESKKKKKT VPKRDLLVLL DDIITTRKKN NRMMGQVLGG GSDGPPLEDL DPPRRILKK- ---GKKKKKR VQGGPMMLQQ EEGQDDLVVT TDLLPGSTRG GQSVSS-RNH HAA------- ---------- --DRRFFWTT EEGQDDLVVT TDAAPKSQYG GKTLSS-RNH HDD------- ---------- --DRRLLWAA PPLRRIYIDD TTKNPPREPP PKIKVEEPPE EEVVSGYSLH TTVVVHCCCC GPINNE---- PPLRRIYIDD TTKDKKRRPP PAAKIEEPPV VVRRTGYTYH TTVVVHCCCC GPIGGP---- PPLRRIYVDD TTKHPPTQAA ARHKIEEPPE EEKKTGYSPH TTVVVHCCCC GPIGGAGGGK PPLRRIYIDD TTKDPPTKAA AKHKIEEPPE EEKKTGYSPH TTIIIHCCCC GPIGGGGGGK PPIRRIYIDD VVKEPPLKAA AKHKIEEPPE EEKKTGYSPH TTIIIHCCCC GPIGGGGGGE PPLRRIYIDD TTKDPPLKPP PFAKVEEPPT TTRRTGYSPH TTVVVHCCCC GPINNA---- PPIRRITIDD TTKDPPTQPP PKVKVDDPPE EERRTGYAPH TTVVVHCCCC GPISSP---- PPIRRIHIDD TTKDPPREPP PRVKVEEPPE EERRTGYSPH TTIIIHCCCC GPVSSP---- PPLMMIYVDD VVGEPPRAPP PKHKVEEAAE EEKKCNVSTH TTSSSHCCCC LAEGGD---- PPIIIIYVDD VVGEPPRAPP PKHKVEEPPE EEKKCNLGLH TTSSSHCCCC LAEGGD---- PPLMMIYVDD VVGDPPRAPP PKHKVEEAAD DDKKCGLGVH TTSSSHCCCC LAEGGD---- PPLIIIYVDD VVGEPPRAPP PKHKVEEPPD DDKKCNLGFH TTSSSHCCCC LPEGGD---- PPLIIIYVDD VVGEPPRAPP PKHKVEEPPD DDKKCELALH TTSSSHCCCC LAEGGD---- ---------- ---------- -------PPD DDKKCELALH TTSSSHCCCC LAEGGD---- PPLIIIYVDD VVGEPPRAPP PKHKVEEPPD DDKKCELALH TTSSSHCCCC LAEGGD---- PPLIIIYVDD VVGEPPRAPP PKHKVEEPPD DDKKCELALH TTSSSHCCCC LAEGGD---- PPFIIIYVDD VVGEPPRAPP PKHKVEEAAD DDKKCGLGPH TTSSSHCCCC LPEGGD---- PPL------- ---------- ---------- ---------- ---------- ---------- PPLIIIYVDD VVGEPPRAPP PKHKVEEPPD DDKKCELALH TTSSSHCCCC LAEGGD---- PPLLLVYVDD TTADPPRTPP PSHKVEESSD DDNNIGLGPH TTSSSHCCCC LADGGD---- PPLIIIYVDD VVGDPPRAPP PRHKTEEPPE EEKKCGLALH TTSSSHCCCC LGEGGD---- PPLIIIYVDD VVGDPPRAPP PRHKTEEPPE EEKKCGLAPH TTSSSHCCCC LGEGGD---- PPLVVIYVDD TTKNPPRSPP PSHKVDDPPD DDKKTGLAPH TTSSSHCCCC LAEGGD---- PPIVVVYVDD TTKNPPRAPP PSHKVEEPPD DDKKTGLAPH TTSSSHCCCC LAEGGD---- PPLIIIYADD TTKNPPRAPP PSYKYDDPPE EEKKTGLAPH TTAAAHCCCC LAEGGD---- PPLIIIYADD TTKNPPRAPP PSYKYDDPPE EEKKTGLAPH TTAAAHCCCC RTEGGD---- PPLLLVYVDD TTLDPPRAPP PAHKVEEAAD DDKKTGLGPH TTSSSHCCCC LAEGGD---- PPLNNIYINN VVEE--RKII IYEHTEEPPK KKLLN-LSPH TTSSSHCCCC LANGGE---- PPLNNIYVNN VVEE--REII IYQHTEEPPK KKLLN-LSPH TTSSSHCCCC LANGGE---- RRLSSEGKFF VVG------- ---------- ---------- ---------- ---------- PPLNNIFVDD TTGDPPRAPP PKAKVEEGGD DDGGADCTPH TTTTTHCCCC LPNGGD---- PPLNNIYIDD VVVDPPRKPP PEVKTDDGGD DDSSHNVTPH TTTTTHCCCC LANGGD---- LLLDDLYVTT SSLSAAWDKK KQYP-----D DDFFLVLASH TTAAADYYYY QPANNE---- GGLDDIFIDD VVHDPPSNPP PKHKTDDTTF FFSSGGVVPH TTFFFFAAAA LPMNND---- GGLDDIFVDD VVHDPPARPP PVSKTTTDDF FFSSGGVVPH TTLLLYAAAA LPMNNN---- EG-EEGGPGG GGIILMMLHS EPLLGIDDRG GGYY------ -------LLY DWWNN-LVSS DGREEGGPGG GGIIFLLLHT EPIIGVYYRG GGYY------ -------FFY DWWNN-MITT DGTDDGGAPG GGIIFIIMCT DVLLGIDDRG GGDD------ -------KKY DWWNN-MVSS DGTNNGGPPG GGVVFIIMCT EVLLGIDDRG GGTT------ -------LLY DWWNN-MVTT DGTDDGGPPG GGIIFIILCT EILLGMDDRG GGTT------ -------KKY DWWNN-MVSS EG-KKGGPGG GGIIAMMLAS EPLLGVEERG GGYY------ -------FFY DWWHH-LVTT EG-EEGGPGG GGIIFIILHN EVLLGIDDRG GGYY------ -------LLY DWWHH-LLTT EG-DDGGPGG GGVVFVVMHS DPLLGVEERG GGQQ------ -------LLY DWWHH-MVTT LQGNNGGKGS SSFFVLLLGT EVKKGKPPGG GGPP------ -------MMY DYYQQ-MVSS PQGNNGGKGG GGFFVLLLGT EVKKGKPPGG GGPP------ -------MMY DYYQQ-MVSS SKGNNGGKGG GGFFVLLLGT EVKKGQPPGG GGPP------ -------MMY DYYQQ-MISS PEGNNGGKGG GGFFVLLLGT EVKKGQPPGG GGPP------ -------LLY DYYQQ-MISS VKGNNGGKGG GGFFVLLLGT EVKKGRPPGG GGPP------ -------SSY DYYQQ-MISS VKGNNGGKGG GGFFVLLLGT EVKKGRPPGG GGPP------ -------LLY DYYQQ-MISS VKGNNGGKGG GGFFVLLLGT EVKKGRPPGG GGPP------ -------LLY DYYQQ-MISS VKGNNGGKGG GGFFVLLLGT EVKKGRPPGG GGPP------ -------LLY DYYQQ-MISS PKGNNGGKGG GGFFVLLLGT EVKKGRPPGG GGPP------ -------MMY DYYQQ-MISS ---------- ---------- ---------- ---------- ---------- ---------- VKGNNGGKDG GGSSLVVLPR ECSSG----- ---------- ---------- ---------- KEGNNAAAGN NNGGFLLLDE NVKKGNRRLF FFSS------ -------KKR TYYEEYFWSS PYGNNGGKGG GGFFVLLLGT EVKKGAEEGE EEPP------ -------FFY DYYQQ-MISS PCGNNGGKGG GGFFVLLLGT EVKKGVEEGE EEQQ------ -------FFY DYYQQ-MISS KDGNNAAEGN NNGGFLLLDD NVKKGKPPGH HHLL------ -------FFY DYYQQ-MISS KDGNNAAEGN NNGGFLLLDE NVKKGKPPGH HHLL------ -------FFY DYYQQ-MISS EEGNNAAKGN NNGGFLLLDD NIKKNKPPGH HHLL------ -------FFY DYYQQ-MISS EEGNNAAKGN NNGGLLLLDD NIKKNKPPDI IILL------ -------YYY HYYQQ-MISS KEGNNAAAGN NNGGFLLLDE NVKKGKPPGH HHLL------ -------FFY DYYQQ-MISS ANGTTPPSGN NNFFLLLLGT EPKKGADDEK KKPP------ -------FFY DYYQQ-MISS ADGSSPPSGN NNFFLLLLGT EPKKGADDGK KKPP------ -------FFY DYYQQ-MISS ---------- ---------- ---------- ---------- ---------- --------SS AEGNNAAKG- --DDFVVEDN ELVVGRGGDR RRLL------ -------CCY DYYQQ-MVAA AEGYYAAKG- --DDFIILDD NCIIGKGGDK KKLL------ -------CCY DYYQQ-MVSS SLSVVPPVLN NNGGIQQTKE GLSSAASSQF FFII------ -------LLL SNNNN-SESS DDHGGGGRTA AALLVEEYDG YVAATPTTAD DDQQGAVVAA AAAGGGGYYY DAALL-MLTT KDHGGGGRTA AALLVEEYNG YVAATPTTDG GGRRGAIIKA AAAGGGGYYY DAALL-LVTT SEEEWWAPN- ---TTIIEDD LLKLEHHDD- --YGGNFWWL LLRRKRRIHT TTLGGGENNA SEEEWWTPR- ---CCFFEEE FFSLECCEEG GGYGGNVWWL LLAAKRHLYD DDLGGGQHHV SEEEWWAPP- ---QQFFENN IIVPEDDAAN NNYGGHFWWL LLRRARNVQD DDLGGGAHHA SEEEWWAPP- ---QQFFENN IIVPEDDSSN NNYGGHFWWL LLRRARNVQD DDLGGGAHHA SEEEWWGPP- ---QQFFENN IIVPEDDSSN NNYGGHFWWL LLRRDRNVQD DDLGGGAHHA SEEEWWGPD- ---MMVVEDD LLVPDIIGGA AAYGGRFWWL LLTTRRHLQD DDFGGGDHHV SEEEWWGPR- ---MMVVESS VVLGDEEAAG GGYGGHVWWL LLYYRRHLQD DDLGGGAYYA SEEEWWGPN- ---MMIIEGG LLDPQIINNK KKYGGRIWWL LLRRRRHLQD DDVGGGEHHV TEEEWWAPN- ---VVFFKDD NNPAHVV--G GGYGGSVWWW WWQQRHIIQQ QQMTTT-DDI TEEEWWAPN- ---VVFFKDD NNPAHVV--G GGYGGSVWWW WWQQRHIIQQ QQMKKK-DDI TEEEWWAPN- ---VVFFRDD NNPADVV--G GGYGGSVWWW WWQQRHIIQT TTLQQQ-DDI TEEEWWAPN- ---VVLLRDD NNPADVV--G GGYGGSVWWW WWQQRRIVQP PPLQQQ-DDI TEEEWWAPN- ---VVLLRDD NNPADVV--G GGYGGSVWWW WWQQHHIVQS SSLKKK-DDI TEEEWWAPN- ---VVLLRDD NNPADVV--G GGYGGSVWWW WWQQRHIVQS SSLKKK-DDI TEEEWWAPN- ---VVLLRDD NNPADVV--G GGYGGSVWWW WWQQRHIVQS SSLKKK-DDI TEEEWWAPN- ---VVLLRDD NNPADVV--G GGYGGSVWWW WWQQRHIVQS SSLKKK-DDI TEEEWWAPN- ---VVVVQNN NNPADVV--G GGYGGKVWWW WWQQRHIVQL LLMPPP-DDI ---------- ---------- ---------- ---------- ---------- ---------- AIIISSASN- ---LLRRLTT RRDYPAA--S SSVAAG---- ---------- ---------- WIIIQQCSL- ---FFYYTTT EELMCLL--S SSVHHVLDDY YYIIMRIDEP PPLQQQ-DDG TEEEWWGPK- ---AAFFALL KKMEEVV--G GGYGGHVWWW WWTTEHRIQD DDLGGGEDDI TEEEWWGPK- ---AAFFALL KKMEDVV--G GGYGGHVWWW WWTTEHLVQD DDLGGGKDDI TSSSWWGPT- ---AAFFTKK DDLQHVV--G GGYGGRCIIL LLAARGLRQD DDLGGGNTTL TSSSWWGPK- ---AAFFLQQ NNLQHVV--G GGYGGRVYYW WWPPGGIKQD DDLGGGDKKL TSSSWWGPK- ---AAFFSKK DDLQHVV--G GGYGGSVYYW WWPPGGMKQD DDLGGGETTL TSSSWWGPK- ---AAFFSKK NNLQHVV--G GGYGGSVYYW WWPPGGIKQD DDLGGGPTTL SSSSWWGPA- ---AAFFRTT DDLQHVV--G GGYGGRVYYW WWPPGGLKQD DDLGGGSTTL TEEEWWGPN- ---HHIIKKK NNPAHVV--G GGYGGNIFFW WWDDSKYLQD DDLPPPQLLL TEEEWWGPN- ---HHIIKKK NNPAHVV--G GGYGGNIFFW WWDDTKHLQD DDLPPPMRRL ILLLRRGPV- ---TTVVCRR EELKCQQ--P PPVIIKVYY- ---------- ---------- SEEEWWGPK- ---LLFFRRR HHPTDCCRRT TTYGGCFYYW WWQQERLFQD DDLGGGDDDT SEEEWWGPN- ---KKWWRRR KKNVDLLMMS SSYGGCFYYW WWSSTQLYQD DDLGGGSDDT DRRRPPDPI- ---MMAAFEE EESFLKKGGP PPKPPQEVV- ---------- ---------- SSSSFFTWSN YYYMMMMDFF MMLQDAAMMK KKFGGNQWWL LLHHTRPKKN NNVPPPGPP- SSSSFFTWNN YYYMMMMDFF MMLADPPMMK KKFGGNTWWL LLHHTKPKKD DDVPPPGPP- AL------EL PPPPTTKKKG GFFISLKDLS SIIILWW-WE EVIIEEIIIP AEEPLNNLPE VL------EV PPPPTTKKKG GFFVNTKDLS SIIILWW-WE EVIIDDIIIE AQQPFPPLPP AL------EV PPPPVVRRRG GFFVDTTNLG SIIITWW-FK KTAATTIIIP AEEPAEELPP AL------EV PPPPVVRRRG GFFVDTTNLA SIIITWW-FE ETAATTIIIP PEEPAKKLPP AL------EI PPPPSSKKKG GFFCDTTNLG AIIITWWKFK KTIITTIIID PVVPADDLPD VF------EL PPPPTTKKKG GFFVSLKDLS SIIITWW-WR RVIIEEIIIP AEEAAQQLPP AL------EL PPPPTTKKKG GFFMSLKDLA SIIILWW-WK KVIIDDIIIP AEEPAQQLPP VL------EL PPPPAARRRG GFFVSLEDLA SVVVLWW-WR RVIIEEIIIP AEEPAQQLPP IP------EI FFPPSSAAAG GFFVSSNIQF YKKKEEE--- --TTWWSSSV EKKVISSKKV IP------EI FFPPDDAAAG GFFVSSNIQF YKKKEGG--- --TTWWSSSV EKKVISSKKV IP------EI FFPPDDAAAG GFFVSSTIQF YKKKQGG--- --TTWWSSSV EKKVIPPKKV IP------EI FFPPDDAAAG GFFVSSTIQF FKKKEDD--- --TTWWSSSA QKKVIPPKKV IP------EI FFPPDDAAAG GFFVSSTIQF YKKKEGG--- --TTWWSSSV EKKVIPPKKV IP------EI FFPPDDAAAG GFFVSSTIQF YKKKEGG--- --TTWWSSSV EKKVIPPKKV IP------EI FFPPDDAAAG GFFVSSTIQF YKKKEGG--- --TTWWSSSV EKKVIPPKKV IP------EI FFPPDDAAAG GFFVSSTIQF YKKKEGG--- --TTWWSSSV EKKVIPPKKV IP------EI FFPPAAAAAG GFFVSSTIQF YKKKEGG--- --TTWWSSSV EKKVIPPKKV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GANNPPPICL SSKKNNIIID DYYDSFSGRG SDDDDAA--- --AAVVVVVL KRRKLYYAVV IP------EI FFPPDDAAAG GLLVSSTVFF YKKKKDD--- --KKWWAAAA EKKVISSKKV IP------EI FFPPDDAAAG GLLVSSSIFF YKKKKDD--- --KKWWAAAA EKKVISSKKV LP------EI FFPPAAKKKG GFFVSSNMIF FKKKQDD--- --SSWWSSSH ELLAIPPLKV LP------EI FFPPAAKKKG GFFVTSNMIF FKKKQDD--- --SSWWNNNH EIIVIPPLKV LP------EI FFPPSSKKKG GYYVSSNMIF FKKKSDD--- --TTWWSSSY EIIVIPPLKV LP------EI FFPPSSKKKG GFFVSSNMIF FKKKSDD--- --TTWWSSSH EVVVIPPLKV LP------EV FFPPSSKKKG GYYVTSNMVF FKKKADD--- --SSWWSSSH EVVAIPPLKV LP------EV FFPPTTSSSA AFFVGSGIFI HPPPEEE--- --TTHHAAAA TLLVASSKKV LP------EV FFPPTTSSSA AFFVGSAIFI HPPPEKK--- --VVQQTTTA SLLVASSKKV ---------- ---------- ---------- ---------- ---------- ---------- TP------EI FFPPRREEEG GYYVXXXXXX X--------- ---------- --------QG TP------EI FFPPKKKKKG GFFVNAKVFF KKKKSDD--- -FEEAAKKKK VIIDILLVDT ---------- ---------- ---------- ---------- ---------- ---------- --------EI FFSSNNAAAA AFFSTSQLWI YEEEDAA--- ---------- -----AAKAV --------EI CCEEAAHHHC CFFTTSQLWI YEEEGEE--- ---------- -----AAKAV IKPFFFFKAV PPVTTTDDID DKKKLLYLSS WWWGEEVRQI IISNNPFFFF KPLTTKKVKR VKDFFFFKMV PPVTTTDDID DRRRLLYVSS WWWGEELRQI IITNNPHHHH QPLAARRVKR LQGFFFFGAV PPVTTTDDLD DRRRLLYVSS WWWGEEMRQV VVSDDPHHHH NPLAASSVRR LQGFFFFGAV PPVTTTDDLD DRRRLLYVSS WWWGEEMRQV VVSDDPRRRR KPLAASSVHR LKGFFFFGAC PPVTTTDDLD DKKKLLYVAA WWWGEEMHQV VVSDDPMMMM NPLTTKKVEK VKGFFFFKAV PPVTTTDDLD DRRRLLYVSS WWWGDDLLQV VVSDDPFFFF EPLTTKKVRR IKPFFFFKAV PPVTTTDNLD DRRRLLYVSS WWWGEELHQV VVSDDPFFFF NPLTTKKVQR LKDFFFFGAV PPVTTTDNLD DRRRLLYVSS WWWGEELRQV VVSDDPFFFF NPHTTSSVRK KWMLLLLPEM GGITTTDLLD DRRRLLYFSS WWWLDDIRQI IISNNPQQQQ KPLTTQQIFR KWMLLLLPEM GGITTTDLLD DRRRLLYFSS WWWLDDIRQI IISNNPKKKK KPLTTQQIFK KWMLLLLPEM GGITTTDLLD DRRRLLYFSS WWWLDDLRQI IISDDPQQQQ RPLTTQQLFK KWMLLLLPEM GGITTTDLLD DHHHLLYFSS WWWLDDIRQV VVSDDPQQQQ RPLTTQQLFK KWLLLLLPEM GGITTTDLLD DRRRLLYFSS WWWLDDLRQI IISDDPQQQQ RPLTTQQLFK KWLLLLLPEM GGITTTDLLD DRRRLLYFSS WWWLDDLRQI IISDDPQQQQ RPL------- KWLLLLLPEM GGITTT---- ---------- ---------- ---------- ---------- KWLLLLLPEM GGITTTDLLD DRRRLLYFSS WWWLDDLRQI IISDDPQQQQ RPLTTQQLFK KWMLLLLPEM GGITTTDLLD DRRRLLYFNN WWWLDDMRQI IISDDPKKKK RPLVVQQIFK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AFGVVVVVSL NNFPPPPWIS DLLLIIIFLL ---------- ---------- ---------- EWALLLLPEM GGITTTDLID DRRRLLYFSS WWWLDDIRQI IITDDPRRRR NPLVVQQIFR EWPMMMMPEM GGITTTDLID DRRRLLYFSS WWWLDDIRQI IITDDTRRRR NPLVVQQIFR QWILLLLPEM GGITTTDLID DRRRLLYFVV WWWLDDIRQI IIEDDLKKKK NPLTTQQLWK QWFLLLLPEM GGITTTDLID DRRRLLYFVV WWWLDDIRQI IIEDDVKKKK NPLTTQQVWK EWILLLLPEM GGITTTDLID DRRRLLYFVV WWWLDDIRQI IIEDDPKKKK NPLTTQQIWK EWILLLLPEM GGITTTDLID DRRRIIYFVV WWWLDDIRQI IIEDDPKKKK NPLTTQQIWK RWILLLLPEM GGITTTDVID DRRRLLYLVV WWWLDDIRQI IIEDDPAAAA KPLAAQQVWK SWALLLLPEM AAITTTDLID DRRRLLYVSS WWWLDDIRQI IISDDPLLLL KVLNNQQVYT EWALLLLPDM AAITTTDLID DRRRLLYVSS WWWLDDIRQI IISDDPKKKK NPLNNQQVFS ---------- ---------- ---------- ---------- ---------- ---------- EGEIIIIEMM GGMTTTDLID DRRRLLYFSS WWWRDDVRQI IISDDRAAAA NPLTTQQVFR GGVAAAAEDM GGISSSDIID DRRRLLYVNN WWWRDDVRQI IITDDPEEEE NPLTTQQLFS ---------- ---------- ---------- ---------- ---------- ---------- AIGNNNNPAD PPPVVVDSID DQQQLLWINN FFFMKKTRLI IISDDPHHHH KPQIIEEKV- AIGEEEEPAK PPPVVVDSID DSSSLLWVNN FFFMKKTRLI IISDDPHHHH HPQVVEEKT- RAADHH---- ---------- -----AAGHH LTPPLLIRRR RVVVYVTTNN LLSWWDNNQE REEPHH---- ---------- -----SSGAA ATPPIIVRRR RVVVYITTNN LLSWWNNNQ- RAAPHH---- ---------- -----NNGRR FAPPVVIRRR RVVVYWTTNN LLSWWDDDQD RTTPHH---- ---------- -----NNGKK FAPPVVIRRR RVVVYWTTNN LLSWWDDDQD KTTPHH---- ---------- -----NNGKK FGPPVVIKRR RVVVYWTTNN LLSWWDEEQG RAATHH---- ---------- -----KKNGG LNPPVVIRRR RVVVYFTTNN LLGVVDPPQE RAAGHH---- ---------- -----TTSAA LNPPVVIRRR RVVVYFTTNN LLRWWDEEQD KAAAHH---- ---------- -----AASGG LNPPVVVRRR RVVVYFSSNN LLAWWDEEQV RGGGSSVVLL -DDEEEECCC CQPELKKGKK IPPPIILKRR RLLLYATTTT LLSWWDKKQP KGGGSSVVLL -DDEEEECCC CQPELKKGKK VPPPIILKRR RLLLYVTTTT LLSWWDKKQP KGGGPPVVLL -DDEEEESSS SQPELKKGKK VPPPIILKRR RLLLYVTTTT LLSWWDKKQP KDDGPPVVLL -DDEEEESSS SQPELKKGKK VAPPIILKRR RLLLYVTTTT LLSWWDKKQP KGGGPPVVLL -DDEEEESSS SQPELKKGKK VAPPIILKRR RLLLYITTTT LLSWWDKKQP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KGGGPPVVLL -DDEEEESSS SQPELKKGKK VAPPIILKRR RLLLYITTTT LLSWWDKKQP KGGGPPVVLL -DDEEEESSS SQPELKKGKK VPPPIILKRR RIIIYVTTTT LLSWWDKKQP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RGGGPPVVLL -DDDDDDCCC CQPDVKKGKK VPPPIILKRR RLLLYVTTNN LLSWWDKKQP RGGGPPVVLL -DDEEEECCC CQPDVKKGKK IPPPIILKRR RIIIYVTTSS LLSWWDKKQP KGGSPPAAII -EEGGGGWWW WQSDPQQGQQ LRPPIILKRR RLLLYVTTNN LLSWWDKKQP KGGSPPAAVV -DDGGGGWWW WQSDPQQGKK LRPPIILKRR RLLLYVTTNN LLSWWDKKQP KGGSPPAAVV -EEGGGGFFF FQFDPKKGKK LRPPIILKRR RLLLYATTNN LLSWWDRRQP KGGSPPAAVV -EEGGGGFFF FQFEPKKGKK LRPPIILKRR RLLLYATTNN LLSWWVVVSP KGGSEEYYVV -EEDDDDEEE EQYSPKKGHH LRPPIILKRR RIIIYVTTNN LLSWWDEEQQ TEESNNVVLL -GGKKKK--- -PIELKKGRR IEPPLLLKRR RLLLYVTTTT LLKWWDDDQP SEETTTVVLL -EEHHHH--- -EIPLKKGRR IEPPLLLKRR RLLLYVSSTT LLKWWDDDQP ---------- ---------- ---------- --PPIILKRR RLLLYVTTNN FFSWWDKKQP RDDAPPVVLL -DDEEEEEEE EAPEVKKGRR LLPPLLLRRR RLLLYVSSSS LLSWWDKKQP SDDLPPIIVV EDDEEEEEEE ERPPRKKGRR LEPPLLLKRR RLLLYVSSSS LLSWWDKKQP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----VVQKRR RVVVYFSSSS LLAWWD---- ---------- ---------- ---------- ----VVSQRR RLLLYYTTSS LLAWWD---- EGKWWVKLLN N------PGG LEFFDGEE-- -SSSHHQVVR RLGGGDDDAD SYYCCC---- -GRWWAKVVN N------PGG LEFFDGRR-- -AAAHHQVVR RLGGGDDDAD SFFCCC---- DGPAAVLAAH G------PGG LDYWEPDDG- -AAAHHQIIR RLGGGDDDCD SFFCCCKR-- DGPVVVMAAN G------GGG LDYFSPDDG- -AAAHHQIIR RLGGGDDDCD SFFCCC---- GDGAAVMAAN G------EGG LDFWDPAAG- -SSSHHQIIR RLGGGDDDCD SFFCCC---- EGDWWVKLLD G------PGG IKFFEPKKG- -PPPHHQVVR RLGGGDDDCD SYYCCC---- DGKWWVKVVD N------PGG MNFFDGEE-- -VVVHHQIIR RLGGGDDDAD SYYCCC---- VGRWWAKAAE D------PGG LGFFEGDDG- -PPPHHQIIR RLGGGDDDSD SYYCCC---- PDIEESVMML VDVVTTTVGG LNFLDGKKEP LAAAHHELLR RYGGGDDDCD IWWIII---- PNIEESVMML IDVVTTTAGG LNFLDGKKEP LAAAHHELLR RYGGGDDDCD IWWIII---- PDIEESVMML IDVVTTTVGG LNFLDGKKEP LAAAHHELLR RYGGGDDDCD IWWLLL---- PDIEESVMML IDVVTTTVGG LNFLDGKKEP LAAAHHELLR RYGGGDDDCD IWWLLL---- PDIEESVMML VDVVTTTVGG LNFLDGKKEP LAAAHHELLR RYGGGDDDCD IWWIII---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PDIEESVMML VDVVTTTVGG LNFLDGKKEP LAAAHHELLR RYGGGDDDCD IWWIII---- PDIEESVMML IDVVTTTVGG LNFLDGKKEP LAAAHHEIIR RYGGGDDDCD IWWLLL---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PDIEESVMML IDVVTTTEGG LNFLDGKKEP GAAAHHELLR RYGGGDDDCD IWWVVV---- PDLEEAVMML IDVVTTTKGG LNFLDGKKEP DAAAHHEIIR RYGGGDDDCD IWWIII---- PGVKKSHIIL IDVVTTTEGG LNFFDGAAEP DAAAHHEMMR RYGGGDDDCD IWWIII---- PKVQQSHIIL IDVVTTTEGG LNFFDGAAEP DAAAHHEMMR RYGGGDDDCD IWWIII---- PEMKKSHIII IDVVTTTEGG LNFFDGDDEP EAAAHHEMMR RYGGGDDDCD IWWIII---- PEMKKSHIII IDGGTTTEGG LDFFDGDDEP DAAAHHEMMR RYGGGDDDCD IWWIII---- QDVKKSHMML IDVVTTTEGG LNFFDGAAEP EAAAHHEMMR RYGGGDDDCD IWWIII---- PEVSSATMMV VNIIPPPEGK MDFLDGKKIE GAAAHHEMMR RYGGGDDDCD IWWIII---- PEVSSATMML IDVVPPPIGH MNFLDGKKVP GAAAHHEMMR RYGGGDDDCD IWWIII---- PNVEESVMML IDVVTTTEGG LNFLDGKKEP NAAAHHDIIR RFCGGDDDSD ILLAAA---- PEVAAGTIIV LDIIVVVEGG MNFLDGGGEP YPPPHHEMMR R--------- ---------- PKVQQGHIIV IDVVTTTVGG IDFLDANNEP YPPPHHEMMR RYGGGDDDCD IWWLLL---- ---------- ---------- ---------- ---------- ---------- ---------- ---KKKDDDA YLKKYYYNDG KDFADYEELG LAAAHHIMMR RFSSSAAALS ---------- ---KKKDDDE FLKKYYYYDG KQFADYAAEK LPPPHHQMMR RFARRAAALG PAAGGGLVQQ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QAARREE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NAAKAKKKQP PSAATTCTTT TTTGLTTAAA ADDAQLLRRR TQLLSSSLLP GSVRRRAAYQ gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- --------MA gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EEEAAWWTTT SSQQVLAAAS SSRRSEESKK KKKTTRSSSS VVPPPGLESS SAAVPSQAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGRRAAPPP PPNNNRTTTP TTHHPNNPLL LLASSPPPPP HHPPPRVLRL LPPINVPPPR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---AIIVVVP PFRRPTFFPS KKMMMMEDDA YAACLTGTTT ---------- ---------- ----MMAAAK KLPPPTFFPT RRDDMMEDDA YAAALVGTTT ---------- ---------- ------MMMS SMPPPTFFAS EELLMMEEEA YLLLLPDFFF ---------- ---------- ------MMMT TMPPPTFFAS KKLLMMENNA YLLLLPDFFF ---------- ---------- ------MMMT TLPPPTFFPS KKLLMMEKKA FLLMLPDAAA ---------- ---------- ----MMAAAT TWPPPSFFPS RRLLAAETTA YAAMFPERRR ---------- ---------- ----MMVVVT TWPPPTFFPS RRMMVVEKKA YVVRLPMAAA ---------- ---------- ----MMAAAS SWPPPTFFPS KKMMMMERRG YAALLPGRRR ---------- ---------- --AKCCTTTK K-CCPGYYTP EEAAKKEEEV YPPCIRNTTT ---------- ---------- ---------- ---------- ----MMEEEV YPPCIRNTTT VWAAHLGKKH HHAGLLLLP- -ASQCCGGGK K-CCPGYYSP EEAAKKEEEV YPPCIGNTTT ---------- ---------- ---------- ---------- ----KKEEEI YPPCIRNTTT ---------- ---------- --AKCCGGGN N-CCPGYYTP EEAAKKEEEV YPPCIRNTTT ------RAAE EEAPMMMRPA ASAKCCGGGN N-CCPGYYTP EEAAKKEEEV YPPCIRNTTT ---------- ---------- --AKCCGGGN N-CCPGYYTP EEAAKK---- ---------- ---------- ---------- --AKCCGGGN N-CCPGYYTP EEAAKKEEEV YPPCIRNTTT ----MLEEEP PPHGQQQLWE EDAKCCGGGD D-CCPGYYTP EEAAKKEEEV YPPCIRNTTT -LLLKSCLLG GGDYCCCTLF FTPKCCGGGN N-CCPGYYTP EEAAKKEEEV YPPCIRNTTT ---------- ---------- --AKCCGGGN N-CCPGYYTP EEAAKKEEEV YPPCIRNTTT LCPPPASLLV VVQVEEETAA AAGTCCCCCH HTKKPGYYTP EEAAEEEKKV YTTCVNGTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MKCCGGGS S-CCPGYYSP DDAAKKEEEV YPPCIRSTTT ---------- ---HGGGVVE EKSVNNGGGC CCSSPGYYSP EESSSSESSI YTTAVAGTTT ---------- ---HAAAVVE EKNQQQGGGC CCSSPGYYSP EEAASSETTI YTTAVAGTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RRMMML LQGGPGYYTP AAAASSEKKI YTTAVTGTTT ---------- -------MAA AAGACCCCCG GGTTPGYYTP EEAAEEEKKL YTTCVNGTTT ---------- --------MP PNGKCCHHHG G---PGYYSP DDAAKKEEEL FTTAP--NNN ---------- --------M- --PKCCHHHG G---PGYYSP DDAAKKEEEL FTTAP--HHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---SEESSSK KCCCPGYYTP DDAARREKKL YVVCVPNLLL ---------- ---------- ---------- ---------- ----RREKKL YVVTVPNLLL ---------- ---------- ---------- ----PGLLT- DDIIIIRFFY FNNWLGDIII -----MREEF FF-ALLLAA- -AAGLLPPPF FRFFDETTQS YYMMKKEEEV YWWTLVEGGG -----MFIIV VVGALLLVSL LAAAAAPPPA AGRRDETTAS YYMMKKEDDV YWWTLAEGGG IINDDFFIVD DDDNSEETTT KIVVVVHKVV VEEEEYYIND LHHGGGNNCS SSSSSSALCG VVNDDFFLVD DDDDSPPTTT KVIIIIYKLL LDDDDYYIGD LHHGGGNNCS SSSSSSAYCA ---DDAALVD DDDKSSSTTT KIVVVVHTVV VTTTTNNTGD FHHGGGNNCS SSSSSSSLST ---DDAALVD DDDKSPPTTT QIVVVVHTVV VTTTTNNKGD FHHGGGNNCS SSSSSSALSA ---DDGGLVD DDDDSEEKKK QIVVVVHQLL LIIIINNKGD FHHGGGNNCS SSSSSSALST ---DDAAIVD DDDDSPPRRR SIVVVVGQVV VAAAAHHAGD LHHGGGNNCS SSSSSSCLCA GG-DDAAMVD DDDDSSSTTT QVVVVVGVTT TDDDDYYTGG LHHGGGNNCS SSSSSSMLCA ---DDAALVD DDDDSGGTTT QIVVVVGRVV VEEEENNAAD LHHGGGNNCS SSSSAAALCA TTEDDYYLTD DDDDSPPQQQ QVIIIIHRLL LPPPPYYLKD LHHGGGNNCS SSSSSSC--F IIEDDYYLTD DDDDSPPHHH QVIIIIHRLL LPPPPHHLKD LHHGGGNNCS SSSSSSC--F IIEDDYYLTD DDDDSPPQQQ QVIIIIHRLL LPPPPNNLRD LHHGGGNNCS SSSSSSC--F IIEDDYYLTD DDDDSPPQQQ QVIIIIHRLL LPPPPHHLKD LHHGGGNNCS SSSSSSC--Y TTEDDYYLTD DDDDSPPQQQ QVIIIIHRLL LPPPPNNLKD LHHGGGNNCS SSSSSSC--F TTEDDYYLTD DDDDSPPQQQ QVIIIIE--- ---------- ---------- ---------- TTEDDYYLTD DDDDSPPQQQ QVIIIIHRLL LPPPPNNLKD LHHGGGNNCS SSSSSSC--F TTEDDYYLTD DDDDSPPQQQ QVIIIIHRLL LPPPPNNLKD LHHGGGNNCS SSSSSSC--F TTEDDYYLTD DDDDSPPQQQ QVIIIIHRLL LPPPPYYLKD LHHGGGNNCS SSSSSSC--F TTEDDYYLTD DDDDSPPQQQ QVIIIIHRLL LPPPPNNLKD LHHGGGNNCS SSSSSSC--F TTEDDYYLTD DDDDSPPQQQ QVIIIIHRLL LPPPPNNLKD LHHGGGNNCS SSSSSSC--F IINDDYYLTD DDDDSPPTTT QVIIIIHRLL LPPPPHHIGD LHHGGGNNCS SSSSSSC--H ---------- ---------- ---------- -----NNTND LHHGGGNNCS SSSSSSC--Y IINDDYYLTD DDDDSPPSSS QVIIIIHRLL LPPPPNNVND LHHGGGNNCS SSSSSSC--Y IIEDDYYLTD DDDDSPPTTT KVIIIIHRLL LPPPPYYVGD LHHGGGNNCS SSSSSSC--H IIEDDYYLTD DDDDSPPTTT KVIIIIHRLL LPPPPYYVGD LHHGGGNNCS SSSSSSC--H ---------- ---------- ---------- -----FFVGD LHHGGGNNCS SSSSSSC--H IIDDDYYLTD DDDDSPPSSS SVIIIIHRLL LPPPPFFVGD LHHGGGNNCS SSSSSSC--H IINDDYYLTD DDDDSPPTTT QVIIIIHRLL LPPPPHHVGD LHHGGGNNCS SSSSSSC--H AADDDAAITD DDDNSDDTTT QVIIIISRVV VDDDDHHIGD VHHGGGNNCS SSSSSSC--H RRDDDAAITN NNNNSEETTT QIIIIISRVV VDDDDNNIGD VHHGGGNNCS SSSSSSC--H ---------- ---------- ---------- ---------- ---------- ---------- EEEDDYYLTD DDDDSPPTTT QVIIIIHRTT TYYYYSSKHN LHHGGGNNCS SSSSSSCHFG EEPDDYYLTD DDDDSPPTTT QIVVVVHRTT TFFFFRRKGD LHHGGGNNCS SSSSSSCYYS QQYTTDDRNR RRRVVFFLLL SVLLLLKDGG GPPPPVVLED EDDQQQTTRI IIIILLK--- GGDDDKKLTD DDDRSAATTT QVIIIINSVV VSSSSGG-RN AHHGGGSS-- ---------- GGDDDKKLTD DDDNSPPQQQ KVVVVVNTLL LSSSSGG-RN AHHDDDTT-- ---------- KPEERLLIVV VVGLLRSSRI DTKKPPNNPR EPIKVPPPEE EVVKKSYRRL LHVVVHHCCG KPEERLLIVV VVALLRSSRV DTKKPPDDKR RPVKIPPPEE EAAGGTYKKY YHVVVHHCCG HAEERLLIII IIGLLRSSRI DTKKPPHHPT QAIKIPPPDD DIIAATYRRP PHVVVHHCCG HAEERLLIII IIGLLRSSRI DTKKPPDDPT KAIKIPPPEE EVVKKTYRRP PHIIIHHCCG HAEERLLIII IIGIIRSSRV DVKK--EEPL KAIKIPPPEE EVVAATYRRP PHIIIHHCCG HPEERLLVVV VVGLLRSSRL DTKKPPDDPL KPLKVPPPEE ELLEETYRRP PHVVVHHCCG HPEERLLVVV VVDIIRSSHL DTKKPPDDPT QPVKVPPPNN NLLEETYRRP PHVVVHHCCG HPEERLLIVV VVGIIRSSRV DTKKPPDDPR EPIKVPPPEE ELLRRTYRRP PHIIIHHCCG DSSSRLLILL LLGLLMSSRV DVGGSSEEPR APLKVAAASS SIIAACVNNT THSSSHHCCL DSSSRLLILL LLSIIISSRV DVGGSSEEPR APLKVPPPNN NIIAACLNNL LHSSSHHCCL DSSSRLLMLL LLCLLMSSRV DVGGSSDDPR APLKVAAAEE EIIAACLYYV VHSSSHHCCL DIAARLLVLL LLALLISSRV DVGGTTEEPR APLKVPPPKK KIITTCLFFF FHSSSHHCCL DSSSRLLVLL LLSLLISSRV DVGGSSEEPR APLKVPPPEE EIIAACLFFL LHSSSHHCCL ---------- ---------- ---------- -----PPPKK KIIAACLFFL LHSSSHHCCL DSSSRLLVLL LLSLLISSRV DVGGSSEEPR APLKVPPPKK KIIAACLFFL LHSSSHHCCL DSSSRLLVLL LLSLLISSRV DVGGSSEEPR APLKVPPPKK KIIAACLFFL LHSSSHHCCL DSSSRLLVLL LLSFFISSRV DVGGTTEEPR APLKVAAAKK KIIEECLTTP PHSSSHHCCL DSSSRLLVLL LLSLL----- ---------- ---------- ---------- ---------- DSSSRLLVLL LLSLLISSRV DVGGSSEEPR APLKVPPPKK KIIAACLFFL LHSSSHHCCL DPKKRLLILL LLSLLLGGRV DTAATTDDPR TPLKVSSSEE EIIEEILFFP PHSSSHHCCL DAVVRLLILL LLCLLISSRV DVGGTTDDPR APIKTPPPYY YVVWWCLNNL LHSSSHHCCL DSVVRLLILL LLCLLISSRV DVGGSSDDPR APIKTPPPYY YVVWWCLNNP PHSSSHHCCL DPEERLLIAA AASLLVGGRI DTKKTTNNPR SPLKVPPPAA AIIQQTLYYP PHSSSHHCCL DPQQRLLIVV VVGIIVGGRI DTKKTTNNPR APLKVPPPEE EIITTTLYYP PHSSSHHCCL DADDRLLVLL LLSLLIGGRI DTKKEENNPR APLKYPPPKK KIIEETLYYP PHAAAHHCCL DADDRLLVLL LLSLLIGGRI DTKKEENNPR APLKYPPPKK KIIDDTLFFP PHAAAHHCCR DPSSRLLILL LLSLLLGGRV DTLLKKDDPR APLKVAAAEE EIIEETLFFP PHSSSHHCCL KPKKRLLIVV VVCLLNDDRI NVEENNEE-R KILHTPPPSS SLLSSNLFFP PHSSSHHCCL KPKKRLLIVV VVCLLNDDRI NVEENNEE-R EILHTPPPSS SLLAANLFFP PHSSSHHCCL -----MMVPP PPKLLSGGVV FVGGGG---- ---------- ---------- ---------- KETTRLLVLL LLCLLNDDRI DTGGTTDDPR APLKVGGG-- -VVKKACAAP PHTTTHHCCL KTKKRLLVLL LLSLLNDDFL DVVVTTDDPR KPIKTGGG-- -VVKKHVAAP PHTTTHHCCL KRGGGMMLQQ QQSLLDKKRT TSLLYYSSAW DKFP------ -LLKKLLIIS SHAAADDYYQ --DDRFFWTT TTGLLDNNRF DVHHSSDDPS NPLKTTTT-- -VVDDGVGGP PHFFFFFAAL --DDRLLWAA AAGLLDSSKF DVHHSSDDPA RPLKTDDD-- -VVKKGVGGP PHLLLYYAAL PPDAAIYYAG GGN-EGG--P GGILLLDDHY FEEPLGGGWE IRGGDQ---- ---------L PPDAAIYYAG GGG-DGGRRP GGIFLLDDHD FEEPIGGGWE VRGGPQ---- ---------F PPEGGIYYTG GGGKDGGTTA PGIFMMDDCE FDDVLGGGWE IRGGPQ---- ---------K PPDGGIYYTG GGGKDGGTTP PGVFMMDDCE FEEVLGGGWE IRGGPQ---- ---------L PPEGGIYYTG GGGEDGGTTP PGIFLLDDCE FEEILGGGYE MRGGEQ---- ---------K PPGGGIYYAG GGN-EGG--P GGIALLDDAQ FEEPLGGGWE VRGGPQ---- ---------F PPDGGIYYAG GGS-EGG--P GGIFLLDDHD LEEVLGGGWE IRGGDQ---- ---------L PPDGGVYYAG GGS-EGG--P GGVFMMDDHE FDDPLGGGWE VRGGPQ---- ---------L AASGGEVVNL LLG-LQQGGK GSFVLLDDGE FEEVKGGGWE KGGGAS---- ---------M AASGGEVVSL LLG-PQQGGK GGFVLLDDGE FEEVKGGGWE KGGGEA---- ---------M AASGGEVVSL LLG-SKKGGK GGFVLLDDGE FEEVKGGGWE QGGGAA---- ---------M PPSGGEVVSL LLG-PEEGGK GGFVLLDDGK FEEVKGGGWE QGGGAA---- ---------L AASGGEVVSL LLG-VKKGGK GGFVLLDDGE FEEVKGGGWE RGGGAA---- ---------S AASGGEVVSL LLG-VKKGGK GGFVLLDDGE FEEVKGGGWE RGGGAA---- ---------L AASGGEVVSL LLG-VKKGGK GGFVLLDDGE FEEVKGGGWE RGGGAA---- ---------L AASGGEVVSL LLG-VKKGGK GGFVLLDDGE FEEVKGGGWE RGGGAA---- ---------L PPTGGEVVSL LLG-PKKGGK GGFVLLDDGE FEEVKGGGWE RGGGSA---- ---------M ---------- ---------- ---------- ---------- ---------- ---------- AASGGEVVSL LLG-VKKGGK DGSLLLLLP- LEECSGGG-- ---------- ---------- AASGGDIISL LLG-KEEGGA GNGFLLLLDS FNNVKGGGGS NLFFPI---- ---------K GGCGGEIISI IIG-PYYGGK GGFVLLDDGE FEEVKGGGWE AGEEAA---- ---------F GGCGGEIISL LLG-PCCGGK GGFVLLDDGE FEEVKGGGWE VGEESA---- ---------F AASGGELLSL LLG-KDDGGE GNGFLLLLDS FNNVKGGGWE KGHHSP---- ---------F AASGGEIISI IIG-KDDGGE GNGFLLLLDS FNNVKGGGWE KGHHSP---- ---------F AASGGEIISL LLG-EEEGGK GNGFLLLLDS FNNIKNNNWE KGHHSP---- ---------F TT-GGEIISL LLG-EEEGGK GNGLLLLLDS FNNIKNNNWE KDIISP---- ---------Y AASGGEIISL LLG-KEEGGA GNGFLLLLDS FNNVKGGGWE KGHHSP---- ---------F AADGGNIISL LLG-ANNGGS GNFLLLDDGK FEEPKGGGWP AEKKTV---- ---------F AADGGNIISL LLG-ADDGGS GNFLLLDDGK FEEPKGGGWP AGKKVV---- ---------F ---------- ---------- ---------- ---------- ---------- ---------- PPNGGNIISM MMG-AEEGGK G-DFEEFFDK FEELVGGGWS RDRRKA---- ---------C AANGGNIISM MMG-AEEGGK G-DFLLFFDS FNNCIGGGWT KDKKKA---- ---------C PPNTTALLDV VVN-SLLSSV LNGITTSSKH NGGLSAAAGE AQFFEE---- ---------L PPGSSMMMGS SSN-DDDHHR TALVYYNNDD EYYVATTTWM PADDDMGGGG DAAAVVADGY PPGRRMLLGS SSN-KDDHHR TALVYYTTNA EYYVATTTWI PDGGDLGGGG -KKKYYADGY LAADWLL-NN EEEVVVLVSS WWW--TTTII DGG-LLEHKK D--RRYNIFW WDRRRKRLLL FAADWLL-SS GGGVVVMISS WWW--CCCFF EGG-FFECKK EGGAAYNLVW WDARRRHILL KHHDWLL-RR DDDYYYMVSS WWW--QQQFF NGG-IIEDLL ANNKKYHLFW WDRRRRNILL LHHDWLL-RR DDDYYYMVSS WWW--QQQFF NGG-IIEDLL SNNKKYHLFW WDRRRRNILL KHHDWLL-RR DDDYYYMVSS WWW--QQQFF NGG-IIEDLL SNNKKYHIFW WKRRRKNILL FAADWLL-YY DDDTTTLVSS WWW--MMMVV DGG-LLDILL GAARRYRLFW WDTRRRHIFF LHHDWLL-YY DDDTTTLLSS WWW--MMMVV SGG-VVDELL AGGKKYHLVW WDYRRRHLLL LAADWLL-YY DDDTTTMVSS WWW--MMMII GGG-LLQILL NKKGGYRLIW WDRRRRHLVV MGGDYPP-HH NNNVVVMVTT WWW--VVVFF DGGFNNHVAA -GGLLYSIVW WDQHHEILMM MGGDYPP-HH NNNIIIMVTT WWW--VVVFF DGGFNNHVAA -GGLLYSIVW WDQHHEILMM MGGDYPP-HH NNNVVVMITT WWW--VVVFF DGGFNNDVAA -GGLLYSLVW WDQHHEILLL LGGDYPP-HH NNNVVVMITT WWW--VVVLL DGGFNNDVAA -GGLLYSLVW WDQRREILLL SGGDYPP-HH NNNVVVMITT WWW--VVVLL DGGFNNDVAA -GGLLYSLVW WDQHHEILLL LGGDYPP-HH NNNVVVMITT WWW--VVVLL DGGFNNDVAA -GGLLYSLVW WDQHHEILLL LGGDYPP-HH NNNVVVMITT WWW--VVVLL DGGFNNDVAA -GGLLYSLVW WDQHHEILLL LGGDYPP-HH NNNVVVMITT WWW--VVVLL DGGFNNDVAA -GGLLYSLVW WDQHHEILLL MGGDYPP-HH NNNVVVMITT WWW--VVVVV NGGFNNDVAA -GGLLYKLVW WDQHHEILMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AA SSS--LLLRR TGGSRRPAAA -SSRRVGT-- ---------- KEETYNNYWW GGGLLLFWWW QQQ--FFFYY TGGAEECLAA -SSGGVVSLD DNIRRVILLL FGGDYPP-HH NNNVVVMITT WWW--AAAFF LGGFKKEVAA -GGMMYHLVW WDTHHRRILL FGGDYPP-HH NNNVVVMITT WWW--AAAFF LGGFKKDVAA -GGHHYHLVW WDTHHRLILL FGGDYPP-HH NNNTTTMITT WWW--AAAFF KGGFDDHVDD -GGLLYRLCI IQAGGELLLL FGGDYPP-HH NNNTTTMITT WWW--AAAFF QGGFNNHVDD -GGLLYRLVY YSPGGEILLL FGGDYPP-HH KKKTTTMITT WWW--AAAFF KGGFDDHVDD -GGLLYSLVY YSPGGEMILL YGGHYPP-HH KKKTTTMITT WWW--AAAFF KGGFNNHVDD -GGLLYSLVY YSPGGEIILL FGGDYPP-HH KKKTTTMISS WWW--AAAFF TGGFDDHVDD -GGLLYRLVY YDPGGELLLL FNNDYPP-RR NNNVVVMITT WWW--HHHII KGGFNNHVEE -GGLLYNVIF FEDKKKYILL FNNDYPP-RR NNNIIIMITT WWW--HHHII KGGFNNHVEE -GGLLYNVIF FEDKKKHILL ---------- --------II RRR--TTTVV RDDEEECQEE -PPLLVKKVY Y--------- CGGDYPP-FF NNNVVVMVSS WWW--LLLFF RGGYHHDCDD RTTQQYCLFY YRQRRELILL CGGDYPP-FF DDDVVVMVSS WWW--KKKWW RGGWKKDLDD MSSQQYCLFY YKSQQTLILL LQQSNGG-RR EEEKKKSEDD PPP--MMMAA ESSSEELKTT GPPLLKQVEV VL-------- YGGDAII-KK NNNVVVMLSS FFFNNMMMMM FGGQMMDAAA MKKRRFNIQW WDHRRQPFVV YDDDAPP-KK NNNLLLLVSS FFFNNMMMMM FGGKMMDPAA MKKHHFNVTW WDHKKQPFVV ERA---ELLR PPPLPLMMMF FIIIVVSSLS SSIIILEGGK IEEEAAEEEG GGGNLLPEEE ERV---EVVR PPPLPLMMMF FVVVVLNNLS SSIIILEGGR IDDDAAQQEG GGGPLLPPPP QQA---EVVR PPPAPEYYYF FVVVVVDDLE EGIIITEGGK ATTTAAEETA AAAELLPPPP NQA---EVVR PPPAPEYYYF FVVVVVDDLE EAIIITEGGK ATTTPPEEPK KKKKLLPPPP NQA---EIIR PPPAPDYYYF FCCCVVDDLQ QGIIITDGGK ITTTPPVVDA AAADLLPDDD EQV---ELLR PPPAPAYYYF FVVVVISSLS SSIIITDDDK IEEEAAEEDP PPPQLLPPPP EQA---ELLR PPPAPAYYYF FMMMVVSSLS SAIIILDGGK IDDDAAEESE EEEQLLPPPP EQV---ELLR PPPAPTYYYF FVVVVVSSLS SAVVVLQGGK IEEEAAEEEP PPPQLLPPPP -GI--LEIIR FFFLPTQQQF FVVVALSSQR RFKKKE---- TWWWEEKKQV VVVSKKKVVV -GI--LEIIR FFFLPTQQQF FVVVALSSQR RFKKKE---- TWWWEEKKQV VVVSKKKVVV -GI--LEIIR FFFLPAQQQF FVVVALSSQR RFKKKQ---- TWWWEEKKQV VVVPKKKVVV -GI--LEIIR FFFLPAQQQF FVVVALSSQR RFKKKE---- TWWWQQKKQV VVVPKKKVVV -GI--LEIIR FFFLPAQQQF FVVVALSSQR RFKKKE---- TWWWEEKKQV VVVPKKKVVV -GI--LEIIR FFFLPAQQQF FVVVALSSQR RFKKKE---- TWWWEEKKQV VVVPKKKVVV -GI--LEIIR FFFLPAQQQF FVVVALSSQR RFKKKE---- TWWWEEKKQV VVVPKKKVVV -GI--LEIIR FFFLPAQQQF FVVVALSSQR RFKKKE---- TWWWEEKKQV VVVPKKKVVV -GI--LEIIR FFFLPSQQQF FVVVALSSQR RFKKKE---- TWWWEEKKEV VVVPKKKVVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -QGNPLCLLR SSSIKNQQQY YDDDEVSSRG GGDDDD---- AVVVKKRRDL LLLYAAVVVV -GI--LEIIR FFFLPAQQQL LVVVALSSFR RFKKKK---- KWWWEEKKKV VVVSKKKVVV -GI--LEIIR FFFLPDQQQL LVVVALSSFR RFKKKK---- KWWWEEKKQV VVVSKKKVVV -GL--LEIIR FFFLPDTTTF FVVVALSSIR RFKKKQ---- SWWWEELLPV VVVPLLKVVV -GL--LEIIR FFFLPDTTTF FVVVALTTIR RFKKKQ---- SWWWEEIISV VVVPLLKVVV -GL--LEIIR FFFLPDTTTY YVVVALSSIR RFKKKS---- TWWWEEIISV VVVPLLKVVV -GL--LEIIR FFFLPDTTTF FVVVALSSIR RFKKKS---- TWWWEEVVSV VVVPLLKVVV -GL--LEVVR FFFLPDTTTY YVVVALTTVR RFKKKA---- SWWWEEVVSI IIIPLLKVVV PGL--LEVVR FFFLPEHHHF FVVVALGGFR RIPPPE---T THHHTTLLFI IIISKKKVVV PGL--LEVVR FFFLPEHHHF FVVVALGGFR RIPPPE---K VQQQSSLLTI IIISKKKVVV ---------- ---------- ---------- ---------- ---------- ---------- -GT--LEIIR FFFLPNQQQY YVVVAFXXXX XX-------- ---------- ------QGGG -GT--LEIIR FFFLPAEEEF FVVVALNNFH HFKKKS---E EAAAVVIIPG GGGLVVDTTT ---------- ---------- ---------- ---------- ---------- ---------- A----LEIIR FFFPSNYYYF FSSSALTTWL LIEEED---- --------EW WWWAKKAVVV A----LEIIR CCCAENYYYF FTTTALTTWL LIEEEG---- --------EW WWWAKKAVVV IKKPFKKKVP PTDIDDISDK FFYSLLLWWV VRRQQQYYDI IINPPFKPVL TTTGGGVKGI VKKDFKKKVP PTDIDDISDR FFYSLLLWWL LRRQQQYYDI IINPPHQPRL AAAGGGVKGL LQQGFGGGVP PTDIDDLSDR FFYSCCCWWM MRRQQQYYDV VVDPPHNPVL AAAGGGVRGI LQQGFGGGVP PTDIDDLSDR FFYSCCCWWM MRRQQQYYDV VVDPPRKPKL AAAGGGVHGI LKKGFGGGCP PTDIDDLSDK YYYACCCWWM MHHQQQYYDV VVDPPMNPVL TTTGGGVEGI VKKGFKKKVP PTDIDDLSDR FFYSCCCWWL LLLQQQYYDV VVDPPFEPKL TTTGGGVRGI IKKPFKKKVP PTDINNLSDR FFYSCCCWWL LHHQQQYYDV VVDPPFNPRL TTTGGGVQGI LKKDFGGGVP PTDINNLSDR FFYSCCCWWL LRRQQQYYDV VVDPPFNPRH TTTGGGVRGI KWWMLPPPMG GTDILLLSDR FFYSNNNWWI IRRQQQYYDI IINPPQKPRL TTTGGGIFGS KWWMLPPPMG GTDILLLSDR FFYSNNNWWI IRRQQQYYDI IINPPKKPRL TTTGGGIFGS KWWMLPPPMG GTDILLLSDR FFYSNNNWWL LRRQQQYYDI IIDPPQRPRL TTTGGGLFGS KWWMLPPPMG GTDILLLSDH FFYSNNNWWI IRRQQQYYDV VVDPPQRPRL TTTGGGLFGS KWWLLPPPMG GTDILLLSDR FFYSNNNWWL LRRQQQYYDI IIDPPQRPRL TTTGGGLFGS KWWLLPPPMG GTDILLLSDR FFYSNNNWWL LRRQQQYYDI IIDPPQRPRL ---------- KWWLLPPPMG GT-------- ---------- ---------- ---------- ---------- KWWLLPPPMG GTDILLLSDR FFYSNNNWWL LRRQQQYYDI IIDPPQRPRL TTTGGGLFGS KWWMLPPPMG GTDILLLSDR FFYNNNNWWM MRRQQQYYDI IIDPPKRPRL VVVGGGIFGS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AFFGVVVVLN NPPAWWIFSL LLILSSS--- ---------- ---------- ---------- EWWALPPPMG GTDILLISDR FFYSNNNWWI IRRQQQYYDI IIDPPRNPKL VVVGGGIFGS EWWPMPPPMG GTDILLISDR FFYSNNNWWI IRRQQQYYDI IIDTTRNPKL VVVGGGIFGS QWWILPPPMG GTDFLLISDR FFYVNNNWWI IRRQQQYYNI IIDLLKNPVL TTTGGGLWGL QWWFLPPPMG GTDFLLISDR FFYVNNNWWI IRRQQQYYNI IIDVVKNPKL TTTGGGVWGL EWWILPPPMG GTDFLLISDR FFYVNNNWWI IRRQQQYYNI IIDPPKNPVL TTTGGGIWGL EWWILPPPMG GTDFLLISDR FFYVNNNWWI IRRQQQYYNI IIDPPKNPVL TTTGGGIWGL RWWILPPPMG GTDFVVISDR YYYVNNNWWI IRRQQQYYNI IIDPPAKPVL AAAGGGVWGL SWWALPPPMA ATDILLISDR FFYSCCCWWI IRRQQQYYDI IIDPPLKVKL NNNSSSVYGS EWWALPPPMA ATDILLISDR FFYSCCCWWI IRRQQQYYDI IIDPPKNPKL NNNSSSVFGS ---------- ---------- ---------- ---------- ---------- ---------- EGGEIEEEMG GTDILLISDR YYYSNNNWWV VRRQQQYYDI IIDRRANPRL TTTGGGVFGA GGGVAEEEMG GSDIIIISDR FFYNCCCWWV VRRQQQYYDI IIDPPENPKL TTTGGGLFGA ---------- ---------- ---------- ---------- ---------- ---------- AIIGNPPPDP PVDISSIADQ TTWNSSSFFT TRRLLLFFDI IIDPPHKPFQ IIIYYYKVRQ AIIGEPPPKP PVDISSISDS RRWNTTTFFT TRRLLLFFDI IIDPPHHPRQ VVVYYYKTAQ FFRAAPP--- ---------- -----AGKLL TTGDDDGRVY VVTTTNSSLY YYTNNQQQQP YYREEPP--- ---------- -----SGEAA TTGDDDGRVY IITTTNSSLY YYSNNQQQQP AARAAPP--- ---------- -----NGTFF AAGDDDGRVY WWTTTNSSLY YYTDDQQQQP AARTTPP--- ---------- -----NGAFF AAADDDGRVY WWTTTNSSLY YYTDDQQQQP VVKTTPP--- ---------- -----NGTFF GGYDDDGKVY WWTTTNSSLY YYTEEQQQQP VVRAAPPG-- ---------- ----AKNALL NNGDDDGRVY FFTTTNSSLY YYAPPQQQQP VVRAAPP--- ---------- ----ATSELL NNGDDDGRVY FFTTTNSSLY YYAEEQQQQP VVKAAPP--- ---------- -----ASPLL NNGDDDGRVY FFSSSNSSLY YYSEEQQQQP IIRGGVVQVV VEE---DDEE ETPVVKGRII PPGDDDGKLY AATTTTSSLY YYDKKQQQQ- IIKGGVVQVV VEE---DDEE ETPVVKGRVV PPGDDDGKLY VVTTTTSSLY YYAKKQQQQ- IIKGGVVQVV VEE---DDEE EKPVVKGKVV PPGDDDGKLY VVTTTTSSLY YYAKKQQQQ- IIKDDVVQVV VDD---DDEE EDPVVKGQVV AAGDDDGKLY VVTTTTSSLY YYAKKQQQQ- IIKGGVVQVV VEE---DDEE EKPVVKGRVV AAGDDDGKLY IITTTTSSLY YYAKKQQQQ- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIKGGVVQVV VEE---DDEE EKPVVKGRVV AAGDDDGKLY IITTTTSSLY YYAKKQQQQ- IIKGGVVQVV VEE---DDEE EKPVVKGRVV PPGDDDGKIY VVTTTTSSLY YYDKKQQQQ- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIRGGVVTVV VEE---DDDD DEPIVKGKVV PPGDDDGKLY VVTTTNSSLY YYKKKQQQQ- IIRGGVVTVV VEE---DDEE EEPTVKGIII PPGDDDGKIY VVTTTSSSLY YYIKKQQQQ- IIKGGVVAAA AGG---EEGG GTSEIQGKLL RRGDDDGKLY VVTTTNSSLF FFAKKQQQQ- IIKGGVVVAA AKK---DDGG GTSEIQGKLL RRGDDDGKLY VVTTTNSSLF FFAKKQQQQ- LLKGGVVKAA AGG---EEGG GSFQIKGSLL RRGDDDGKLY AATTTNSSLF FFARRQQQQ- LLKGGVVKAA AGG---EEGG GTFQIKGSLL RRGDDDGKLY AATTTNSSLF FFAVVSSSS- LLKGGVVVYY YTT---EEDD DEYQVKGRLL RRGDDDGKIY VVTTTNSSLF FFREEQQQQG VVTEEVVKVV VEE---GGKK K-IYVKGKII EEGDDDGKLY VVTTTTSSLY YYKDDQQQQ- IISEEVVKVV VEE---EEHH H-IYVKGQII EEGDDDGKLY VVSSSTSSLY YYKDDQQQQ- ---------- ---------- ---------- --GDDDGKLY VVTTTNSSFY YYTKKQQQQ- IIRDDRRRVV VNN---DDEE EKPFLKGRLL LLGDDDGRLY VVSSSSSSLF FFPKKQQQQ- IISDDNNVII IKKEEEDDEE EKPYVKGRLL EEGDDDGKLY VVSSSSSSLY YYPKKQQQQ- ---------- ---------- ---------- ---------- ---------- ---------- VV-------- ---------- ---------- ---DDDGKVY FFSSSSSSLL LLN------- VV-------- ---------- ---------- ---DDDGQLY YYTTTSSSLL LLN------- PEELGGWWMK KLNNNNNN-- ---GIDDDEF FFGGGE---- ARRHQSGGDS SSDDYCCYPP P--LGGWWMK KVNNNNNN-- ---GLEEEEF FFGGGR---- ARRHQWGGDT TTDDFCCYPP PDDVAAAAQL LAHHHGGG-- ---GLAAADY WFPPPD---- YRRHQEGGDT TTDDFCCYPP PDDVGGVVEM MANNNGGG-- ---GLDDDDY FFPPPD---- YRRHQEGGDT TTDDFCCYPP PGGRAAAAMM MANNNGGG-- ---GLDDDDF WFPPPA---- YRRHQEGGDT TTDDFCCYPP PEEIGGWWMK KLDDDGGG-- ---GFDDDKF FWPPPK---- HRRHQQGGDS SSDDYCCYPP PDDIGGWWMK KVDDDNNN-- ---GFDDDNF FFGGGE---- QRRHQQGGDS SSDDYCCFPP PVVIGGWWIK KAEEEDDD-- ---GLDDDGF FVGGGD---- LRRHQEGGDS SSDDYCCYPP -PPLRREEGV VMLLLVVVDD DVDGLNNNNF LFGGGKPPLG ALLHEPGGDS SSDDWII--- -PPLRREEGV VMLLLIIIDD DVDGLNNNNF LFGGGKPPLG ALLHEPGGDS SSDDWII--- -PPLRREEGV VMLLLIIIDD DVDGLNNNNF LFGGGKPPLG ALLHEPGGDS SSDDWLL--- -PPLRREEGV VMLLLIIIDD DVDGLNNNNF LFGGGKPPLG ALLHEPGGDS SSDDWLL--- -PPLRREEGV VMLLLVVVDD DVDGLNNNNF LFGGGKPPLG ALLHEPGGDS SSDDWII--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -PPLRREEGV VMLLLVVVDD DVDGLNNNNF LFGGGKPPLG ALLHEPGGDS SSDDWII--- -PPLRREEGV VMLLLIIIDD DVDGLNNNNF LFGGGKPPLG ALLHEPGGDS SSDDWLL--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -PPMKKEEGV VMLLLIIIDD DVDGLNNNNF LFGGGKPPGG VLLHEPGGDS SSDDWVV--- -PPLKKEEGV VMLLLIIIDD DVDGLNNNNF LFGGGKPPDG VLLHEPGGDS SSDDWII--- -PPLEEKKGH HILLLIIIDD DVDGINNNNF FFGGGAPPDG ALLHEPGGDS SSDDWII--- -PPLEEQQGH HILLLIIIDD DVDGINNNNF FFGGGAPPDG SLLHEPGGDS SSDDWII--- -PPLDDKKGH HIIIIIIIDD DVDGINNNNF FFGGGDPPEG ALLHEPGGDS SSDDWII--- -PPIEEKKGH HIIIIIIIDD DGDGINNNDF FFGGGDPPDG SLLHEPGGDS SSDDWII--- GQQLKKKKGH HMLLLIIIDD DVDGINNNNF FFGGGAPPEG SLLHEPGGDS SSDDWII--- -PPHKKSSGT TMVVVVVVNN NIDKINNNDF LFGGGKEEGG YLLHEPGGDS SSDDWII--- -PPNRRSSGT TMLLLIIIDD DVDHINNNNF LFGGGKPPGG YLLHEPGGDS SSDDWII--- -PPVKKEEGV VMLLLIIIDD DVDGVNNNNF LFGGGKPPNG CLLHDPCGDS SSDDLAA--- -PPMAAAAGT TIVVVLLLDD DIDGLNNNNF LFGGGGPPYG GLLHE----- ---------- -PPMSSQQGH HIVVVIIIDD DVDGLNNNDF LFAAANPPYG SLLHEPGGDS SSDDWLLANN ---------- ---------- ---------- ---------- ---------- ---------- ----KKKKGD DDAAAYYYLL LKAGLVVVDF AFYYYEGGLG -RRHIGSSAS SSSS------ ----KKKKGD DDEEEFFFLL LKLGLKKKQF AFYYYAKKLG -RRHQGARAA AAGGAGGDGG ------- ------- K------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LQAARRV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMMMSKAAKK PEEEATTPCA TTARLLLAMM QSSSLLLAQL LLSLTTTPPS SPVVVVRIIK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YQEEEATTTS AAQQVAASPR SSGGGRRKTT TRPLEESSAV AKQQVVVPPS QAAQWAAAHW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MG ---------- ---------- ---------- ---------- ---------- ----LLLLKN ---------- ---------- ---------- ---------- ---------- ---------- MAGGGRPPPP PPNNNTTPPH PPAAAPPASS SPPVLLLLVR PYRRTIINNV PPRPCPPPPH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAAIVPPFFK KRRDPPPPPK KKPPEDDYYY ---------- ---------- ---------- ---MAKKLLK KPPDPPPPPR RRPPEDDYYY ---------- ---------- ---------- ----MSSMMR RPPDPAPPPE EQPAEEEYYY ---------- ---------- ---------- ----MTTMMR RPPDPAPPPK KEPAENNYYY ---------- ---------- ---------- ----MTTLLR RPPDPPAAAK KEPVEKKFFF ---------- ---------- ---------- ---MATTWWK KPPDPPPPPR RKPPETTYYY ---------- ---------- ---------- ---MVTTWWR RPPDPPPPPR RKPAEKKYYY ---------- ---------- ---------- ---MASSWWR RPPDPPPPPK KQPRERRYYY ---------- ---------- ---------M KKKCTKK--- -CCGPTLLLE E-PREEEYYY ---------- ---------- ---------- ---------- ---------- --PREEEYYY LLLPPPPPGK KHHHHAALAA LLLPGG--AH QQQCGKK--- -CCGPSLLLE E-PREEEYYY ---------- ---------- ---------- ---------- ---------- --PREEEYYY ---------- ---------- ---------M KKKCGNN--- -CCGPTLLLE E-PREEEYYY ---AAEEERA AEEEEFFLAA MMRPIIAAST KKKCGNN--- -CCGPTLLLE E-PREEEYYY ---------- ---------- ---------M KKKCGNN--- -CCGPTLLLE E--------- ---------- ---------- ---------M KKKCGNN--- -CCGPTLLLE E-PREEEYYY LLLGGKKKEE EPPPPTTQLL QQLWQQEEDT KKKCGDD--- -CCGPTQQQE E-PREEEYYY SSSQQGGGCL LGGGGQQNHH CCTLVVFFTS KKKCGNN--- -CCGPTLLLE E-PREEEYYY ---------- ---------- ---------M KKKCGNN--- -CCGPTLLLE E-PREEEYYY AAARRHHHSL LVVVVHHMAA EETAAAAAAN TTTCCHHTTA AKKGPTLLLE EKPREKKYYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKKCGSS--- -CCGPSLLLD D-PREEEYYY ---------- -------MLL GGVVNNEEKK VVVNGCCCCK KSSGPSIIIE E-PRESSYYY ---------- -------MLL AAVVSSEEKV QQQQGCCCCK KSSGPSLLLE E-PRETTYYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---RMLLQQV VGGGPTLLLA A-PSEKKYYY ---------- ---------- --MAAAAAAN AAACCGGGGA ATTGPTLLLE EKPREKKYYY ---------- ---------- ---MSSPPNC KKKCHGG--- ---GPSAAAD D-PREEEFFF ---------- ---------- ---MPP---C KKKCHGG--- ---GPSAAAD D-PREEEFFF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSSESKKCCK KCCGPTLLLD DNPVEKKYYY ---------- ---------- ---------- ---------- ---------- -SPREKKYYY ---------- ---------- ---------- ---------- ---MPT---D DSDDRFFFFF MMMKKRRRRE EFFFF----- LLAAGG--AL GGGLPFFRRA AFFADQPPPY YIGQEEEYYY MMMKKRRRFI IVVVVPPMLL LLVSGGLLAL AAAAPAAGGV VRRADAPPPY YIGQEDDYYY YVACCYYYTG GIIINNDDAA AVVVVNPKKE EETYYSHKVE PIIINDEEGN NAACCALLC- YVAAAYYYVG GVVVNNDDAA AVVVVDPKKP PPTYYGYKLD PIIIGDEEGN NAACCAYYC- YTLLLSSSPD S-----DDAA AVIIVKPGGS SSTYYGHTVT PTTTGDEEGN NAACCSLLS- YTLLLSSSPD S-----DDAA AVIIVKPGGP PPTYYGHTVT PKKKGDEEGN NAACCALLS- FTLMMSSSPD S-----DDAA AVVVVDPTTE EEKFFGHQLI PKKKGDEEGN NAACCALLS- YVAMMDDDPE K-----DDAA AVVVVDPAAP PPRYYAGQVA PAAAGDEEGN NAACCCLLC- YVVRRNNNPM NGGG--DDCC CVVVVDSQQS SSTFFGGVTD PTTTGGEEGN NAACCMLLC- YVALLDDDPG E-----DDGG GVLLLDPDDG GGTYYAGRVE PAAAADEEGN NAACCALLC- YLPCCYYYRN GTTTEEDDAA ATVVVDPKKP PPQYYSHRLP PLLLKDEEGN NTTCCC---- YLPCCYYYRN GIIIEEDDAA ATVVVDPKKP PPHYYSHRLP PLLLKDEEGN NTTCCC---- YLPCCYYYGN GIIIEEDDAA ATVVIDPKKP PPQYYCHRLP PLLLRDEEGN NAACCC---- YLPCCYYYRN GIIIEEDDAA ATVVVDPKKP PPQYYCHRLP PLLLKDEEGN NTTCCC---- YLPCCYYYRN GTTTEEDDAA ATVVVDPKKP PPQYYCHRLP PLLLKDEEGN NTTCCC---- YLPCCYYYRN GTTTEEDDAA ATVVVDPKKP PPQYYCE--- ---------- ---------- ---------- -TTTEEDDAA ATVVVDPKKP PPQYYCHRLP PLLLKDEEGN NTTCCC---- YLPCCYYYRN GTTTEEDDAA ATVVVDPKKP PPQYYCHRLP PLLLKDEEGN NTTCCC---- YLPCCYYYRN GTTTEEDDAA ATVVVDPKKP PPQYYSHRLP PLLLKDEEGN NTTCCC---- YLPCCYYYRN GTTTEEDDAA ATVVVDPKKP PPQYYCHRLP PLLLKDEEGN NTTCCC---- YLPCCYYYRN GTTTEEDDAA ATVVVDPKKP PPQYYCHRLP PLLLKDEEGN NTTCCC---- YVTCCYYYNG GIIINNDDAA ATVVLDPSSP PPTYYSHRLP IIIIGDKKGN NSSCCC---- ---------- ---------- ---------- ---------- PTTTNDEEGN NTTCCC---- YLPCCYYYRS GIIINNDDAA ATVVVDPKKP PPSYYSHRLP PVVVNDEEGN NTTCCC---- YVTAAYYYAG GIIIEEDDAA ATVVVDPSSP PPTYYSHRLP PVVVGDEEGN NSSCCC---- YVTAAYYYAG GIIIEEDDAA ATVVLDPNNP PPTYYSHRLP PVVVGDEEGN NSSCCC---- ---------- ---------- ---------- ---------- PVVVGDEEGN NSSCCC---- YVTAAYYYTG GIIIDDDDAA ATVVVDPSSP PPSYYSHRLP PVVVGDEEGN NSSCCC---- YVTCCYYYNG GIIINNDDGG GTVVVDPNNP PPTYYSHRLP TVVVGDEEGN NAACCC---- FVTAA----- AAAADDDDFF FTVVVNPEED DDTFFCSRVD PIIIGDEEGN NAACCC---- FVTAA----- ARRRDDDDFF FTVVVNPEEE EETFFCSRVD PIIIGDEEGN NAACCC---- ---------- ---------- ---------- ---------- ---------- ---------- YVVCCQQQPN DEEEEEDDAA ATVVVDPAAP PPTYYCHRTY NKKKHNEEGN NTTCCCHHFV YTVTTQQQPN DEEEPPDDSS STVVVDPEEP PPTYYCHRTF NKKKGDEEGN NAACCCYYYV FSNWWHHHGD RQQQYYTTKK KNPPMVGQQF FFLGGGKDGP KLLLEDKKQT TPPRRK---- YVWTTGGGVE MGGGDDDDVV VTIILRPGGA AATRRGNSVS G---RNEEGS SAA------- YVWTTGGGAE VGGGDDDDVV VTVVANPKKP PPQYYGNTLS G---RNEEDT TDD------- -NNG---KKK KPNNNNIRRF IPPRSIIDTT KNNNPEPPIK KKVEEPEVKK SYYLTTVHGG -NNA---KKK KPFFFFLRRY IPPRSIIDTT KDDDKRPPAK KKIEEPEAVG TYYYTTVHGG -LLTGGGHHH HAFFFFLRRF IPPRSIIDTT KHHHPQAAHK KKIEEPDILA TYYPTTVHGG -LLAGGGHHH HAFFFFIRRY IPPRSIIDTT KDDDPKAAHK KKIEEPEVFK TYYPTTIHGG -LLTGGGHHH HAFFFFLRRY IPPRSIIDVV KEEEPKAAHK KKIEEPEVFA TYYPTTIHGG -NNAPPPHHH HPHHHHMRRY VPPRSIIDTT KDDDPKPPAK KKVEEPELAE TYYPTTVHGG -NNAPPPHHH HPHHHHVRRY VPPRSIIDTT KDDDPQPPVK KKVDDPNLAE TYYPTTVHGG -YYAPPPHHH HPHHHHVRRY IPPRSIIDTT KDDDPEPPVK KKVEEPELHR TYYPTTIHGG ---FGGGDDD DSTTTTKRNK IPPMSIIDVV GEEEPAPPHK KKVEEASIQA CVVTTTSHLL ---FGGGDDD DSTTTTKRDK IPPISIIDVV GEEEPAPPHK KKVEEPNIHA CLLLTTSHLL ---FGGGDDD DSTTTTKRTK MPPMSIIDVV GDDDPAPPHK KKVEEAEIHA CLLVTTSHLL ---YGGGDDD DITTTTKRTK VPPISIIDVV GEEEPAPPHK KKVEEPKIHT CLLFTTSHLL ---FGGGDDD DSTTTTKRTK VPPISIIDVV GEEEPAPPHK KKVEEPEIHA CLLLTTSHLL ---------- ---------- ---------- ---------- -----PKIHA CLLLTTSHLL ---FGGGDDD DSTTTTKRTK VPPISIIDVV GEEEPAPPHK KKVEEPKIHA CLLLTTSHLL ---FGGGDDD DSTTTTKRTK VPPISIIDVV GEEEPAPPHK KKVEEPKIHA CLLLTTSHLL ---FGGGDDD DSTTTTKRNK VPPISIIDVV GEEEPAPPHK KKVEEAKIHE CLLPTTSHLL ---FGGGDDD DSTTTTKRTK VPP------- ---------- ---------- ---------- ---FGGGDDD DSTTTTKRTK VPPISIIDVV GEEEPAPPHK KKVEEPKIHA CLLLTTSHLL ---HGGGDDD DPSSSSARRF IPPLGVVDTT ADDDPTPPHK KKVEESEIAE ILLPTTSHLL ---YGGGDDD DASSSSKRNK IPPISIIDVV GDDDPAPPHK KKTEEPYVFW CLLLTTSHLL ---YGGGDDD DSSSSSKRNK IPPISIIDVV GDDDPAPPHK KKTEEPYVFW CLLPTTSHLL ---HGGGDDD DPSSSSARRF IPPVGIIDTT KNNNPSPPHK KKVDDPAIIQ TLLPTTSHLL ---HGGGDDD DPSSSSARRF IPPVGVVDTT KNNNPAPPHK KKVEEPEIST TLLPTTSHLL ---HGGGDDD DASSSSARRY VPPIGIIDTT KNNNPAPPYK KKYDDPKIAE TLLPTTAHLL ---HGGGDDD DASSSSVRRY VPPIGIIDTT KNNNPAPPYK KKYDDPKIAD TLLPTTAHRR ---HGGGDDD DPSSSSARRF IPPLGVVDTT LDDDPAPPHK KKVEEAEIAE TLLPTTSHLL ---HDDDKKK KPTTTTERSH IPPNDIINVV EEEE-KIIEH HHTEEPSLHS NLLPTTSHLL ---HDDDKKK KPTTTTERSH IPPNDIINVV EEEE-EIIQH HHTEEPSLHA NLLPTTSHLL ---------- ---------- VRRSGEEFVV G--------- ---------- ---------- V--GGGGKKK KEVVVVPRDR VPPNDIIDTT GDDDPAPPAK KKVEEG-VLK ACCPTTTHLL VEESSSSKKK KTVVVVPRDR VPPNDIIDVV VDDDPKPPVK KKTDDG-VLK HVVPTTTHLL ----GGGKKK KRVVVVQGPQ LLLDKLLTSS LSSSADKKYP PP-----LIK LLLSTTADQQ ---------- -------RRF WGGDNIIDVV HDDDPNPPHK KKTDDT-VKD GVVPTTFFLL ---------- -------RRY WGGDSIIDVV HDDDPRPPSK KKTTTD-VEK GVVPTTLYLL GGPDIIIYSS LE-EG-EPPG GIIIIMDDDD YSFPGKKWI- ---------L LAYYDDW-NN GGPDIIIYSS LP-DGREPPG GIIIILDDDD DTFPGRRWV- ---------F FAYYDDW-SS GGPEIIIYSS LAKDGTDAAG GIIIIIDDDD ETFVGRRWI- ---------K KHYYDDW-RR GGPDIIIYSS LGKDGTNPPG GVVVVIDDDD ETFVGRRWI- ---------L LHYYDDW-RR GGPEIIIYSS LGEDGTDPPG GIIIIIDDDD ETFIGRRYM- ---------K KHYYDDW-RR GGPGIIIYTT LA-EG-KPPG GIIIIMDDDD QSFPGRRWV- ---------F FAYYDDW-YY GGPDIIIYSS LP-EG-EPPG GIIIIIDDDD DNLVGRRWI- ---------L LHYYDDW-YY GGPDVVVYSS LP-EG-DPPG GVVVVVDDDD ESFPGRRWV- ---------L LAYYDDW-YY LLASEEEVVV TD-LQGNKKS SFFFFLDDDD ETFVGTTWK- ---------M MGYYDDW-HH LLASEEEVII SD-PQGNKKG GFFFFLDDDD ETFVGTTWK- ---------M MGYYDDW-HH LLASEEEVII TD-SKGNKKG GFFFFLDDDD ETFVGTTWQ- ---------M MGYYDDW-HH LLPSEEEVVV TD-PEGNKKG GFFFFLDDDD KTFVGTTWQ- ---------L LGYYDDW-HH LLASEEEVII SD-VKGNKKG GFFFFLDDDD ETFVGTTWR- ---------S SGYYDDW-HH LLASEEEVII SD-VKGNKKG GFFFFLDDDD ETFVGTTWR- ---------L LGYYDDW-HH LLASEEEVII SD-VKGNKKG GFFFFLDDDD ETFVGTTWR- ---------L LGYYDDW-HH LLASEEEVII SD-VKGNKKG GFFFFLDDDD ETFVGTTWR- ---------L LGYYDDW-HH LLPTEEEVII TD-PKGNKKG GFFFFLDDDD ETFVGTTWR- ---------M MGYYDDW-HH ---------- ---------- ---------- ---------- ---------- ---------- LLASEEEVII SD-VKGNKKG GSSSSVLLLL -RLCG----- ---------- ---------- LLASDDDIII CD-KEGNAAN NGGGGLLLLL SEFVGRRGN- ---------K KERRTTLYWW LLGCEEEIII SD-PYGNKKG GFFFFLDDDD ETFVGNNWA- ---------F FGYYDDW-HH LLGCEEEIII SD-PCGNKKG GFFFFLDDDD ETFVGNNWV- ---------F FGYYDDW-HH LLASEEELII CD-KDGNEEN NGGGGLLLLL SDFVGRRWK- ---------F FGYYDDW-HH LLASEEEIII CD-KDGNEEN NGGGGLLLLL SEFVGRRWK- ---------F FGYYDDW-HH LLASEEEIVV CD-EEGNKKN NGGGGLLLLL SDFINRRWK- ---------F FGYYDDW-HH RRT-EEEIVV CD-EEGNKKN NGGGGLLLLL SDFINRRWK- ---------Y YGYYHHW-HH LLASEEEIII CD-KEGNAAN NGGGGLLLLL SEFVGRRWK- ---------F FGYYDDW-HH LLADNNNIII TE-ANGTSSN NFFFFLDDDD KTFPGTTWA- ---------F FNYYDDW-RR LLADNNNIII TE-ADGSSSN NFFFFLDDDD KTFPGTTWA- ---------F FNYYDDW-RR ---------- ---------- ---------- ---------- ---------- ---------- LLPNNNNIII ID-AEGNKK- -DDDDVFFFF KNFLGTTWR- ---------C CGYYDDW-FF LLANNNNIII VD-AEGYKK- -DDDDIFFFF SDFCGTTWK- ---------C CGYYDDW-FF QQPNAAALQQ GE-SLSVVVN NGGGGQSSSS HENLAKKGA- ---------L LQLLSSH-RR LLPGMMMMTT LD-DDHGRRA ALLLLENNNN DGEVTYYWPG GAAAVVVDGY YGYYDDR-KK LLPGMMMLTT LN-KDHGRRA ALLLLETTTT AGEVTHHWPG GAAKYYYDGY YDYYDDR-KK NVVSSSSSEE WWWVVNNN-- -IIEDGG--L LKKEHHKKKD DDDD-RGGGR IIHHFFDLRK SIITTSSSEE WWWVVRRR-- -FFEEGG--F FSSECCKKKE EEEEGAGGGK LLHHVVDLAK RVVSSSSSEE WWWLLPPP-- -FFENGG--I IVVEDDLLLA AAAANKGGGR LLHHFFDLRA RVVTTSSSEE WWWLLPPP-- -FFENGG--I IVVEDDLLLS SSSSNKGGGR LLHHFFDLRA RVVSSSSSEE WWWLLPPP-- -FFENGG--I IVVEDDLLLS SSSSNKGGGK IIHHFFKLRD YVVTTSSSEE WWWTTDDD-- -VVEDGG--L LVVDIILLLG GGGGARGGGR LLHHFFDLTR YLLTTSSSEE WWWTTRRR-- -VVESGG--V VLLDEELLLA AAAAGKGGGR LLHHVVDLYR YVVTTSSSEE WWWTTNNN-- -IIEGGG--L LDDQIILLLN NNNNKGGGGR LLHHIIDLRR HVVSSTTTEE WWWAANNN-- -FFKDGGFFN NPPHVVAAA- ----GLGGGR IIFFVVDWQR HVVSSTTTEE WWWAANNN-- -FFKDGGFFN NPPHVVAAA- ----GLGGGH IIHHVVDWQR HIISSTTTEE WWWAANNN-- -FFRDGGFFN NPPDVVAAA- ----GLGGGH LLHHVVDWQR HIISSTTTEE WWWAANNN-- -LLRDGGFFN NPPDVVAAA- ----GLGGGH LLYYVVDWQR HIISSTTTEE WWWAANNN-- -LLRDGGFFN NPPDVVAAA- ----GLGGGH LLYYVVDWQH HIISSTTTEE WWWAANNN-- -LLRDGGFFN NPPDVVAAA- ----GLGGGH LLYYVVDWQR HIISSTTTEE WWWAANNN-- -LLRDGGFFN NPPDVVAAA- ----GLGGGH LLYYVVDWQR HIISSTTTEE WWWAANNN-- -LLRDGGFFN NPPDVVAAA- ----GLGGGH LLYYVVDWQR HIISSTTTEE WWWAANNN-- -VVQNGGFFN NPPDVVAAA- ----GLGGGH LLHHVVDWQR ---------- ---------- ---------- ---------- ---------- ---------- -----AAAII SSSHHNNN-- -RRLTGGSSR RDDPAAAAA- ----SRAAAI TT-------- WWWSSWWWII QQQCCLLL-- -YYTTGGAAE ELLCLLAAA- ----SGHHHI SSCCLLNYIM HIISSTTTEE WWWAAKKK-- -FFALGGFFK KMMEVVAAA- ----GMGGGS LLNNVVDWTE HIISSTTTEE WWWAAKKK-- -FFALGGFFK KMMDVVAAA- ----GHGGGS LLNNVVDWTE HIISSTTTSS WWWAATTT-- -FFTKGGFFD DLLHVVDDD- ----GLGGGH LLTTCCQLAR HIISSTTTSS WWWAAKKK-- -FFLQGGFFN NLLHVVDDD- ----GLGGGH LLHHVVSWPG HIISSTTTSS WWWAAKKK-- -FFSKGGFFD DLLHVVDDD- ----GLGGGH LLHHVVSWPG HIISSTTTSS WWWAAKKK-- -FFSKGGFFN NLLHVVDDD- ----GLGGGH LLHHVVSWPG HIISSSSSSS WWWAAAAA-- -FFRTGGFFD DLLHVVDDD- ----GLGGGH LLHHVVDWPG RIISSTTTEE WWWSSNNN-- -IIKKGGFFN NPPHVVEEE- ----GLGGGS VVHHIIEWDS RIISSTTTEE WWWSSNNN-- -IIKKGGFFN NPPHVVEEE- ----GLGGGS VVHHIIEWDT ---SSIIILL RRRGGVVV-- -VVCRDDEEE ELLCQQEEE- ----PLIIIC KKRRVV---- FVVAASSSEE WWWAAKKK-- -FFRRGGYYH HPPDCCDDDR RRRRTQGGGR LLNNFFRWQE FVVSSSSSEE WWWAANNN-- -WWRRGGWWK KNNDLLDDDM MMMMSQGGGR LLNNFFKWST REESSDDDRR PPPEEIII-- -AAFESSSSE ESSLKKTTTG GGGGPLPPPH VVAAEEL--- KLLTTSSSSS FFFGGSSSNN YMMDFGGQQM MLLDAAAAAM MMMMKRGGGT IIVVQQDLHT KVVTTSSSSS FFFGGNNNNN YMMDFGGKKM MLLDPPAAAM MMMMKHGGGT VVVVTTDLHT RRKKRIIHGL -------EER DDTTKLMGFI NVVSLLLLLK SSIWWLLYDG WNNAAKVVVI RRRRHLLYGL -------EER DDTTKLMGFV NLLNTTTTTK SSIWWLLYDG WQQAARVVVI RRRRNVVQGL -------EER DDVVREYGFV GVVDTTTTTT GGIWWTTRGG FHHVVKTTTA RRRRNVVQGL -------EER DDVVREYGFV GVVDTTTTTT AAIWWTTRGG FHHAAKTTTA RRKKNVVQGL -------EER DDSSKDYGFC GVVDTTTTTT GGIFFTTQDG FEEAAKTTTI RRRRHLLQGF -------EER DDTTKAYGFV NIISLLLLLK SSIWWTTRKD WAAVVKVVVI RRRRHLLQGL -------EER DDTTKAYGFM NVVSLLLLLK AAIWWLLRNG WHHLLKVVVI RRRRHLLQGL -------EER DDAARTYGFV GVVSLLLLLE AAVWWLLRNG WGGIIKVVVI HHEEIIIQTP ------LEER DDSSATQGFV GLLSSSSSSN FFKNNEE--- ---------T HHEEIIIQKP ------LEER DDDDATQGFV GLLSSSSSSN FFKNNEE--- ---------T HHEEIIIQQP ------LEER NNDDAAQGFV GLLSSSSSST FFKNNQQ--- ---------T RREEIVVQQP ------LEER NNDDAAQGFV GLLSSSSSST FFKNNEE--- ---------T HHEEIVVQKP ------LEER NNDDAAQGFV GLLSSSSSST FFKNNEE--- ---------T HHEEIVVQKP ------LEER NNDDAAQGFV GLLSSSSSST FFKNNEE--- ---------T HHEEIVVQKP ------LEER NNDDAAQGFV GLLSSSSSST FFKNNEE--- ---------T HHEEIVVQKP ------LEER NNDDAAQGFV GLLSSSSSST FFKNNEE--- ---------T HHEEIVVQPP ------LEER DDAAASQGFV GLLSSSSSST FFKNNEE--- ---------T ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRVVIDDEQA NPPIIILCCR WWNNINQDYD VVVSFFFFFS GGDPPDD--- ---------A HHRRRIIQGP ------LEER DDDDAAQGLV GLLSSSSSST FFKEEKK--- ---------K HHRRLVVQGP ------LEER NNDDADQGLV GLLSSSSSSS FFKEEKK--- ---------K GGEELRRQGP ------LEER DDAAKDTGFV GLLSSSSSSN FFKTTQQ--- ---------S GGEEIKKQGP ------LEER DDAAKDTGFV GLLTSSSSSN FFKTTQQ--- ---------S GGEEMKKQGP ------LEER DDSSKDTGYV GLLSSSSSSN FFKNNSS--- ---------T GGEEIKKQGP ------LEER DDSSKDTGFV GLLSSSSSSN FFKNNSS--- ---------T GGEELKKQGP ------LEER DDSSKDTGYV GLLTSSSSSN FFKTTAA--- ---------S KKKKYLLQPP ------LEER EETTSEHAFV GLLGSSSSSG IIPVVEES-- -----T---T KKKKHLLQPP ------LEER EETTSEHAFV GLLGSSSSSA IIPDDEEP-- -----K---V ---------- ---------- ---------- ---------- ---------- ---------- RREELFFQGP ------LEER NNRRENQGYV GFFXXXXXXX XX-------- ---------- QQTTLYYQGP ------LEER NNKKKAEGFV GLLNAAAAAK FFKKKSSD-- -----EFFFE ---------- ---------- ---------- ---------- ---------- ---------- RRQQPKKKP- ------LEER GGNNANYAFS TLLTSSSSSQ IIEDDDD--- ---------- KKQQPKKKP- ------LEER GGAAHNYCFT SLLTSSSSSQ IIEDDGG--- ---------- EIIPEELNLP PEILLLKKKV VVPDISSDDD KKFLLYLSSS SIGEERRQYP PPVLGKKVLG DIIEQQFPLP PPVLLLKKKV VVPDISSDDD RRFLLYVSSS SLGEERRQYP PPRLGRRVIG TIIPEEAELP PPLLLLGGGV VVPDLSSDDD RRFLLYVSSS STGEERRQYP PPVLGSSVIG TIIPEEAKLP PPLLLLGGGV VVPDLSSDDD RRFLLYVSSS STGEERRQYP PPKLGSSVIG TIIDVVADLP PDLLLLGGGC CCPDLSSDDD KKYLLYVAAA ALGEEHHQYP PPVLGKKVIG EIIPEEAQLP PPVLLLKKKV VVPDLSSDDD RRFLLYVSSS STGDDLLQYP PPKLGKKVIG DIIPEEAQLP PPILLLKKKV VVPNLSSDDD RRFLLYVSSS STGEEHHQYP PPRLGKKVIG EIIPEEAQLP PPLLLLGGGV VVPNLSSDDD RRFLLYVSSS STGEERRQYP PPRHGSSVLG WSSVKKISKK KVKGGGPPPM MMPLLSSDDD RRFLLYFSSS SHGDDRRQYP PPRLGQQILG WSSVKKISKK KVKGGGPPPM MMPLLSSDDD RRFLLYFSSS SHGDDRRQYP PPRLGQQILG WSSVKKIPKK KVKGGGPPPM MMPLLSSDDD RRFLLYFSSS SHGDDRRQYP PPRLGQQLLG WSSAKKIPKK KVKGGGPPPM MMPLLSSDDD HHFLLYFSSS SHGDDRRQYP PPRLGQQLLG WSSVKKIPKK KVKGGGPPPM MMPLLSSDDD RRFLLYFSSS SHGDDRRQYP PPRLGQQLLG WSSVKKIPKK KVKGGGPPPM MMPLLSSDDD RRFLLYFSSS SHGDDRRQYP PPRL------ WSSVKKIPKK KVKGGGPPPM MMP------- ---------- ---------- ---------- WSSVKKIPKK KVKGGGPPPM MMPLLSSDDD RRFLLYFSSS SHGDDRRQYP PPRLGQQLLG WSSVKKIPKK KVKGGGPPPM MMPLLSSDDD RRFLLYFNNN NHGDDRRQYP PPRLGQQILG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVLRRLYAV VVAKKKVVVL LLSWIFFSSS LLLIIIFLLL L--------- ---------- WAAAKKISKK KVEGGGPPPM MMPLISSDDD RRFLLYFSSS SHGDDRRQYP PPKLGQQILG WAAAKKISKK KVEGGGPPPM MMPLISSDDD RRFLLYFSSS SHGDDRRQYT TPKLGQQILG WSSHLLIPLK KVQNNNPPPM MMPLISSDDD RRFLLYFVVV VHGDDRRQYL LPVLGQQLVG WNNHIIIPLK KVQNNNPPPM MMPLISSDDD RRFLLYFVVV VHGDDRRQYV VPKLGQQVAG WSSYIIIPLK KVENNNPPPM MMPLISSDDD RRFLLYFVVV VHGDDRRQYP PPVLGQQIVG WSSHVVIPLK KVENNNPPPM MMPLISSDDD RRFIIYFVVV VHGDDRRQYP PPVLGQQIVG WSSHVVIPLK KVRNNNPPPM MMPVISSDDD RRYLLYLVVV VHGDDRRQYP PPVLGQQVAG HAAALLASKK KVSGGGPPPM MMPLISSDDD RRFLLYVSSS SHGDDRRQYP PVKLSQQVIG QTTALLASKK KVENNNPPPM MMPLISSDDD RRFLLYVSSS SHGDDRRQYP PPKLSQQVIG ---------- ---------- ---------- ---------- ---------- ---------- ---------Q QGENNNEEEM MMGLISSDDD RRYLLYFSSS SHGDDRRQYR RPRLGQQVLG AKKKIIILVD DTGSSSEEEM MMGIISSDDD RRFLLYVNNN NHGDDRRQYP PPKLGQQLLG ---------- ---------- ---------- ---------- ---------- ---------- -------AKA AVADDDPPPD DDISIAADDD QQTLLWINNN NDGKKRRLFP PPFQYEEKID -------AKA AVADDDPPPK KKVSISSDDD SSRLLWVNNN NDGKKRRLFP PPRQYEEKIG IFFRADD--- ---------- ----GHKTTT PPPPQEIDDR VVYVVTNNYS TWDNNYYYYP LYYREPP--- ---------- ----GAETTT PPPPQSVDDR VVYIITNNYS SWNNNYYYYP IAARAPP--- ---------- ----GRTAAA PPPPQEIDDR VVYWWTNNYS TWDDDYYYYP IAARTPP--- ---------- ----GKAAAA PPPPQEIDDR VVYWWTNNYS TWDDDYYYYP IVVKTPP--- ---------- ----GKTGGG PPPPQEIDDR VVYWWTNNYS TWDEEYYYYP IVVRATT--- ---------- ----NGANNN PPPPQEIDDR VVYFFTNNYG AVDPPYYYYP IVVRAGG--- ---------- ----SAENNN PPPPQEIDDR VVYFFTNNYR AWDEEYYYYP IVVKAAA--- ---------- ----SGPNNN PPPPQEVDDR VVYFFSNNYA SWDEEYYYYP SIIRGGGVL- DDQELLCQQQ PEEVGKRPPP PPPPQQLDDR LLYAATTTYS DWDKKYYYY- SIIKGGGVL- DDQELLCQQQ PEEVGKRPPP PPPPQQLDDR LLYVVTTTYS AWDKKYYYY- SIIKGGGVL- DDQELLSQQQ PEEVGKKPPP PPPPQQLDDR LLYVVTTTYS AWDKKYYYY- SIIKDGGVL- DDQELLSQQQ PEEVGKQAAA PPPPQQLDDR LLYVVTTTYS AWDKKYYYY- SIIKGGGVL- DDQELLSQQQ PEEVGKRAAA PPPPQQLDDR LLYIITTTYS AWDKKYYYY- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SIIKGGGVL- DDEELLSQQQ PEEVGKRAAA PPPPQQLDDR LLYIITTTYS AWDKKYYYY- SIIKGGGVL- DDQELLSQQQ PEEVGKRPPP PPPPQQLDDR IIYVVTTTYS DWDKKYYYY- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SIIRGGGVL- DDKDLLCQQQ PDDIGKKPPP PPPPQQLDDR LLYVVTNNYS KWDKKYYYY- SIIRGGGVL- DDKELLCQQQ PDDTGKIPPP PPPPQQLDDR IIYVVTSSYS IWDKKYYYY- LIIKGSSAI- EEDGKKWQQQ SDDEGQKRRR PPPPQQLDDR LLYVVTNNFS AWDKKYYYY- LIIKGSSAV- DDDGEEWQQQ SDDEGKKRRR PPPPQQLDDR LLYVVTNNFS AWDKKYYYY- LLLKGSSAV- EEDGNNFQQQ FDDQGKSRRR PPPPQQLDDR LLYAATNNFS AWDRRYYYY- LLLKGSSAV- EEDGNNFQQQ FEEQGKSRRR PPPPQQLDDR LLYAATNNFS AWVVVYYYY- LLLKGSSYV- EEDDKKEQQQ YSSQGHRRRR PPPPQQLDDR IIYVVTNNFS RWDEEYYYYG SVVTESSVL- GGEK---PPP IEEYGRKEEE PPPPQQLDDR LLYVVTTTYK KWDDDYYYY- SIISETTVL- EEDHDD-EEE IPPYGRQEEE PPPPQQLDDR LLYVVSTTYK KWDDDYYYY- ---------- ---------- ---------- PPPPAQLDDR LLYVVTNNYS TWDKKYYYY- AIIRDAAVL- DDPELLEAAA PEEFGRRLLL PPPPQQLDDR LLYVVSSSFS PWDKKYYYY- AIISDLLIVE DDKELLERRR PPPYGRREEE PPPPQQLDDR LLYVVSSSYS PWDKKYYYY- ---------- ---------- ---------- ---------- ---------- ---------- QVV------- ---------- ---------- -----SQDDR VVYFFSSSLA NWD------- QVV------- ---------- ---------- -----SSDDR LLYYYTSSLA NWD------- EGLLKKKGGV VKKKN----- PPGGIIIIDD FVVGE----- RRRRSSHRSG AAASSDYC-- -GLLRRRGGA AKKKN----- PPGGLLLLEE FVVGR----- RRRRAAHRWG AAASTDFC-- DGVVPPPAAV VLLLH----- PPGGLLLLAA WVVPD----- RRRRAAHREG CCCSTDFCVV DGVVPPPGGV VMMMN----- GGGGLLLLDD FVVPD----- RRRRAAHREG CCCSTDFCVV GDRRGGGAAV VMMMN----- EEGGLLLLDD WVVPA----- RRRRSSHREG CCCSTDFCVV EGIIDDDGGV VKKKD----- PPGGFFFFDD FLLPK----- RRRRPPHRQG CCCSSDYC-- DGIIKKKGGV VKKKD----- PPGGFFFFDD FVVGE----- RRRRVVHRQG AAASSDYC-- VGIIRRRGGA AKKKE----- PPGGLLLLDD FTTGD----- RRRRPPHREG SSSSSDYC-- PDLLIIIRRS SVVVLDVVDD VVGGLLLLNN LVVGKPLLGP LLLLAAHRPG CCCSSDWI-- PNLLIIIRRS SVVVLDVVDD AAGGLLLLNN LVVGKPLLGP LLLLAAHRPG CCCSSDWI-- PDLLIIIRRS SVVVLDVVDD VVGGLLLLNN LVVGKPLLGP LLLLAAHRPG CCCSSDWL-- PDLLIIIRRS SVVVLDVVDD VVGGLLLLNN LVVGKPLLGP LLLLAAHRPG CCCSSDWL-- PDLLIIIRRS SVVVLDVVDD VVGGLLLLNN LVVGKPLLGP LLLLAAHRPG CCCSSDWI-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PDLLIIIRRS SVVVLDVVDD VVGGLLLLNN LVVGKPLLGP LLLLAAHRPG CCCSSDWI-- PDLLIIIRRS SVVVLDVVDD VVGGLLLLNN LVVGKPLLGP LLLLAAHRPG CCCTSDWL-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PDMMIIIKKS SVVVLDVVDD EEGGLLLLNN LVVGKPGGGP LLLLAAHRPG CCCSSDWV-- PDLLLLLKKA AVVVLDVVDD KKGGLLLLNN LVVGKPDDGP LLLLAAHRPG CCCTSDWI-- PGLLVVVEES SHHHLDVVDD EEGGIIIINN FVVGAPDDGP LLLLAAHRPG CCCTSDWI-- PKLLVVVEES SHHHLDVVDD EEGGIIIINN FVVGAPDDGP LLLLAAHRPG CCCTSDWI-- PELLMMMDDS SHHHIDVVDD EEGGIIIINN FVVGDPEEGP LLLLAAHRPG CCCTSDWI-- PEIIMMMEES SHHHIDGGDD EEGGIIIINN FVVGDPDDGP LLLLAAHRPG CCCTSDWI-- QDLLVVVKKS SHHHLDVVDD EEGGIIIINN FVVGAPEEGP LLLLAAHRPG CCCTSDWI-- PEHHVVVKKA ATTTVNIIDD EEGKIIIINN LIIGKEGGGP LLLLAAHRPG CCCTSDWI-- PENNVVVRRA ATTTLDVVDD IIGHIIIINN LIIGKPGGGP LLLLAAHRPG CCCTSDWI-- PNVVVVVKKS SVVVLDVVDD EEGGVVVVNN LVVGKPNNGP LLLLAAHRPC SSSTSDLA-- PEMMVVVAAG GTTTVDIIDD EEGGLLLLNN LVVGGPYYGP LLLLPPHR-- ---------- PKMMVVVSSG GHHHVDVVDD VVGGLLLLNN LVVANPYYGP LLLLPPHRPG CCCTSDWLAA ---------- ---------- ---------- ---------- ---------- ---------- -------KKK KDDDALKKAA NNDGLLLLVV AVVYEGLLG- RRRRAAHRGS LLLYSS---- -------KKK KDDDELKKLL YYDGLLLLKK AIIYAKLLG- RRRRPPHRGA LLLYAGAGRR ------- ------- VKK---- V------ V------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- A------ ------- ------- RLLARVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NNSAKKKKPS TCRATGLTTA ARLLLAADMQ SLLRAQLSLL TTTTGGVIKK AATTTFFSSA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- SSPPPTTLPP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAIIQVVLAA SSSSSSEESS KRRKKKKTTR PGVAAVKKVV SSQAQWAAHH LPPKKHHAVL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AAAAEEATL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM LGGEEPPHAQ ---------- ---------- ---------- ---------- -----LLLKK SQQLLGGDTN ---------- ---------- ---------- ---------- ---------- ---------- PPLLNNNRTT PPTTPPNNPP LPPAAAASSP PRPVVRYYII VVPRPCPPPP ARRLLVVQIM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M ---------- ---------- ---------- ---------- ---------- ---------M ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MKKEEFF--- ---------- ---------- ---------- ---------- ---------- MKKIIVVGSM ---------- ---------A IVFKRDDPTT SSSSPKAAAP EEDLYYVCCC LTGGIIRRDD ---------- ---------- MALKPDDPTT TTTTPRAAAP EEDIYYVAAA LVGGVVAADD ---------- ---------- -MMRPDDPTT SSSSPEAAAP EEEFYYTLLL LPDD--RRDD ---------- ---------- -MMRPDDPTT SSSSPKAAAP EENFYYTLLL LPDD--KKDD ---------- ---------- -MLRPDDPTT SSSSAKAAGP EEKLFFTMMM LPDD--KKDD ---------- ---------- MAWKPDDPSS SSSSPRAAAP EETIYYVMMM FPEE--QQDD ---------- ---------- MVWRPDDPTT SSSSPRAAAP EEKLYYVRRR LPMMGGKKDD ---------- ---------- MAWRPDDPTT SSSSPKAAAP EERLYYVLLL LPGG--RRDD ---------- ------MMAK CT--CGGPGG PPPPLEMMGP EEEIYYLCCC IRNNTTAADD ---------- ---------- ---------- --------GP EEEIYYLCCC IRNNIIAADD IAAPRRLLLL LPPP--HHSQ CG--CGGPGG PPPPLEMMGP EEEIYYLCCC IGNNIIAADD ---------- ---------- ---------- ------MMGP EEEIYYLCCC IRNNIIAADD ---------- ------MMAK CG--CGGPGG PPPPLEMMGP EEEIYYLCCC IRNNTTAADD QSSVQQMMMM RPPPAATTAK CG--CGGPGG PPPPLEMMGP EEEIYYLCCC IRNNTTAADD ---------- ------MMAK CG--CGGPGG PPPPLEMMG- ---------- ----TTAADD ---------- ------MMAK CG--CGGPGG PPPPLEMMGP EEEIYYLCCC IRNNTTAADD PWWFSSQQQQ LWWWEETTAK CG--CGGPGG PPPPQEMMGP EEEIYYLCCC IRNNTTAADD TEELTTCCCC TLLLFFSSPK CG--CGGPGG PPPPLEMMGP EEEIYYLCCC IRNNTTAADD ---------- ------MMAK CG--CGGPGG PPPPLEMMGP EEEIYYLCCC IRNNTTAADD EGGAAAEEEE TAAAAANNGT CCTAKGGPGG PPPPLEMMGP EEKLYYVCCC VNGGIIKKDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MK CG--CGGPGG PPPPLDMMGP EEEIYYLCCC IRSSIIKKDD ATTVDDGGGG VVVVEEKKSV NGCKSGGPGG PPPPIEMMGP EESLYYVAAA VAGGIIKKDD GTTVQQAAAA VVVVEEVVNQ QGCKSGGPGG PPPPLEMMGP EETLYYVAAA VAGGIIKKDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RMQVGGGPGG PPPPLAMMGP EEKLYYVAAA VTGGIIKKDD ---------- MAAAAANNGA CCGATGGPGG PPPPLEMMGP EEKLYYVCCC VNGGIIKKDD ---------- -MMMPPCCGK CH---GGPGG PPPPADIIGP EEEVFFVAAA P---AAGGDD ---------- -MMM--CCPK CH---GGPGG PPPPADIIGP EEEVFFVAAA P---RRGGDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------S ESCKCGGPGG PPPPLDVVGP EEKLYYVCCC VPNNEEHHDD ---------- ---------- ---------- ------MMGP EEKLYYTTTT VPNNEEHHDD ---------- ---------- -----MMPGG -----DLLLD RRFLFFSWWW LGDDQQDDTT ------LLLL AAAA--LLAG LPRAFAADEE SSSSPYPPTG EEEFYYVTTT LVEEGGEEDD HFFARRLLLL VSSSLLLLAA APGVRAADEE SSSSPYKKTG EEDYYYVTTT LAEEGGEEDD DDFIAVVVDV VYSSKKIEPP IIIINEHHHF FWWWACCAAA LLLPNN--KN NIERRRRRRL DDFLAVVVDV VYGGKKVDPP IIIIGEHHHF FWWWACCAAA YYYPNN--KF FLERRRRRRL DDALAVIIDV VYGGKKITPP TTTTGEHHHF FWWWACCSSS LLLPLLGGHF FLERRRRRRL DDALAVIIDV VYGGQQITPP KKKKGEHHHF FWWWACCAAA LLLPLLGGHF FIERRRRRRL DDGLAVVVDV VFGGQQIIPP KKKKGEHHHF FWWWACCAAA LLLPLLGGHF FLERRRRRRL DDAIAVVVDV VYAASSIAPP AAAAGEHHHF FWWWACCCCC LLLPNNPPHH HMERRRRRRL DDAMCVVVDV VFGGQQVDPP TTTTGEHHHF FWWWACCMMM LLLPNNPPHH HVERRRRRRL DDALGVLLDL LYAAQQIEPP AAAAAEHHHF FWWWACCAAA LLLPYYPPHH HVERRRRRRL DDYLATVVDV VYSSQQVPPP LLLLKEHHHS SWWWTCCCCC ------GGDT TKSRRRRNNL DDYLATVVDV VYSSQQVPPP LLLLKEHHHS SWWWTCCCCC ------GGDT TKSRRRRDDL DDYLATVVDI IYCCQQVPPP LLLLREHHHS SWWWACCCCC ------GGDT TKSRRRRTTL DDYLATVVDV VYCCQQVPPP LLLLKEHHHS SWWWTCCCCC ------GGDT TKARRRRTTL DDYLATVVDV VYCCQQVPPP LLLLKEHHHS SWWWTCCCCC ------GGDT TKSRRRRTTL DDYLATVVDV VYCCQQV--- ---------- ---------- ---------- ---------- DDYLATVVDV VYCCQQVPPP LLLLKEHHHS SWWWTCCCCC ------GGDT TKSRRRRTTL DDYLATVVDV VYCCQQVPPP LLLLKEHHHS SWWWTCCCCC ------GGDT TKSRRRRTTL DDYLATVVDV VYSSQQVPPP LLLLKEHHHS SWWWTCCCCC ------GGDT TKSRRRRNNL DDYLATVVDV VYCCQQVPPP LLLLKEHHHS SWWWTCCCCC ------GGDT TKSRRRRTTL DDYLATVVDV VYCCQQVPPP LLLLKEHHHS SWWWTCCCCC ------GGDT TKSRRRRTTL DDYLATVVDL LYSSQQVPII IIIIGKHHHS SWWWSCCCCC ------GGDS SAKRRRRRRL ---------- --------PP TTTTNEHHHS SWWWTCCCCC ------GGDS SKVRRRRNNL DDYLATVVDV VYSSQQVPPP VVVVNEHHHS SWWWTCCCCC ------GGDS SKVRRRRNNL DDYLATVVDV VYSSKKVPPP VVVVGEHHHT TWWWSCCCCC ------GGDS SAERRRRRRL DDYLATVVDL LYSSKKVPPP VVVVGEHHHT TWWWSCCCCC ------GGDS SAQRRRRRRL ---------- --------PP VVVVGEHHHS SWWWSCCCCC ------GGDS SADRRRRRRL DDYLATVVDV VYSSSSVPPP VVVVGEHHHS SWWWSCCCCC ------GGDS SVDRRRRRRL DDYLGTVVDV VYSSQQVPTT VVVVGEHHHS SWWWACCCCC ------GGDS SASRRRRRRL DDAIFTVVDV VFCCQQVDPP IIIIGEHHHT TWWWACCCCC ------DDKT TEKRRRRSSL DDAIFTVVNV VFCCQQIDPP IIIIGEHHHT TWWWACCCCC ------DDKT TEKRRRRSSL ---------- ---------- ---------- ---------- ---------- ---------M DDYLATVVDV VYCCQQVYNN KKKKHEHHHS SWWWTCCCCC HHHP--GGKV VPTRRRRDDL DDYLSTVVDV VYCCQQIFNN KKKKGEHHHS SWWWACCCCC YYYDEESSKV VPKRRRRDDL TTDRKNPPRM MGGGSSVPKK LLLLEKLDDS SPPPPRRKKK ------GGKV VQGGGGGPPM DDKLVTIIDL LRGGQQVSGG ----REHHHG GFFFA----- ---------- --DRRRRRRF DDKLVTVVDA AYGGKKVSGG ----REHHHS SFFFD----- ---------- --DRRRRRRL LLLVVPGRRS SSRYIIDDDT KKPPNRPPPK KKIIEPPEVK KKSRLHHVHC GPDDIISSAN LLLVVPARRS SSRYIVDDDT KKPPDRPPPA AKVVEPPEAV GGTKYHHVHC GPDDIISSAG LLLIIPGRRS SSRYVIDDDT KKPPHTAAAR RKIIEPPDIL AATRPHHVHC GPEEIVSSTG LLLIIPGRRS SSRYIIDDDT KKPPDTAAAK KKIIEPPEVF KKTRPHHIHC GPDDIVSSTG LLLIIPGRRS SSRYIVDDDV KK--ELAAAK KKIIEPPEVF AATRPHHIHC GPEEIVSSTG LLLVVPGRRS SSRYILDDDT KKPPDLPPPF FKIIEPPELA EETRPHHVHC GPGGIVTTAN LLLVVPDRRS SSHTILDDDT KKPPDTPPPK KKIIDPPNLA EETRPHHVHC GPDDIISSAS LLLVVPGRRS SSRHIVDDDT KKPPDRPPPR RKIIEPPELH RRTRPHHIHC GPDDVVSSAS LLLLLPGMMS SSRYVVDDDV GGSSERPPPK KKIIEAASIQ AACNTHHSHC LASSEMVVNG LLLLLPSIIS SSRYVVDDDV GGSSERPPPK KKIIEPPNIH AACNLHHSHC LASSEMIISG LLLLLPCMMS SSRYVVDDDV GGSSDRPPPK KKIIEAAEIH AACYVHHSHC LASSEMIISG LLLLLPAIIS SSRYVVDDDV GGTTERPPPK KKIIEPPKIH TTCFFHHSHC LPSSEMVVSG LLLLLPSIIS SSRYVVDDDV GGSSERPPPK KKIIEPPEIH AACFLHHSHC LASSEMIISG ---------- ---------- ---------- -----PPKIH AACFLHHSHC LASSEMIISG LLLLLPSIIS SSRYVVDDDV GGSSERPPPK KKIIEPPKIH AACFLHHSHC LASSEMIISG LLLLLPSIIS SSRYVVDDDV GGSSERPPPK KKIIEPPKIH AACFLHHSHC LASSEMIISG LLLLLPSIIS SSRYVVDDDV GGTTERPPPK KKIIEAAKIH EECTPHHSHC LPTTEMIISG LLLLLPS--- ---------- ---------- ---------- ---------- ---------- LLLLLPSIIS SSRYVVDDDV GGSSERPPPK KKIIEPPKIH AACFLHHSHC LASSEMIISG LLLLLPSLLS GGRYVVDDDT AATTDRPPPS SKVVESSEIA EEIFPHHSHC LASSDMIISG LLLLLPCIIS SSRYVVDDDV GGTTDRPPPR RKVVEPPYVF WWCNLHHSHC LGCCEMIISG LLLLLPCIIS SSRYVVDDDV GGSSDRPPPR RKVVEPPYVF WWCNPHHSHC LGCCEMIISG LLLAAPSVVS GGRYVIDDDT KKTTNRPPPS SKVVDPPAII QQTYPHHSHC LASSEMIISG LLLVVPGVVS GGRYVIDDDT KKTTNRPPPS SKVVEPPEIS TTTYPHHSHC LASSEMIISG LLLLLPSIIS GGRYAIDDDT KKEENRPPPS SKVVDPPKIA EETYPHHAHC LASSELVVSG LLLLLPSIIS GGRYAIDDDT KKEENRPPPS SKVVDPPKIA DDTFPHHAHC RT--ELVVSG LLLLLPSLLS GGRYVVDDDT LLKKDRPPPA AKVVEAAEIA EETFPHHSHC LASSEMIISG LLLVVPCNNS DDRYIINNNV EENNERIIIY YHIIEPPSLH SSNFPHHSHC LADDNMIISG LLLVVPCNNS DDRYVINNNV EENNERIIIY YHIIEPPSLH AANFPHHSHC LADDNMIISG MMMPPRKSSS GGVGKVFFFV GGGG------ ---------- ---------- ---------- LLLLLPCNNS DDRFVIDDDT GGTTDRPPPK KKIIEGG-VL KKAAPHHTHC LPNNNMIISG LLLLLPSNNS DDFYILDDDV VVTTDRPPPE EKIIDGG-VL KKHAPHHTHC LANNNMIISG MMMQQLSDDG KKRYVTTTTS LLYYSWKKKQ QP------LI KKLISHHADY QPNNAKQQDN FFFTTGGDDT NNRFIFDDDV HHSSDSPPPK KKIIDTT-VK DDGGPHHFFA LPGGMITTGN LLLAAGGDDT SSKFVFDDDV HHSSDAPPPV VKIITDD-VE KKGGPHHLYA LPGGMITTGN E-EPILLMML LDDDHHFFPL LKWWIDRRRG GDDDYY---- -----LLAAW WNNNNN--NN P-DPIFFLLL LDDDHHFFPI IRWWVYRRRG GPPPYY---- -----FFAAW WNNNNN--SS AKDAIFFIIM MDDDCCFFVL LRWWIDRRRG GPPPDD---- -----KKHHW WNNNNN--RR GKDPVFFIIM MDDDCCFFVL LRWWIDRRRG GPPPTT---- -----LLHHW WNNNNN--RR GEDPIFFIIL LDDDCCFFIL LRYYMDRRRG GEEETT---- -----KKHHW WNNNNN--RR A-EPIAAMML LDDDAAFFPL LRWWVERRRG GPPPYY---- -----FFAAW WHHHHH--YY P-EPIFFIIL LDDDHHLLVL LRWWIDRRRG GDDDYY---- -----LLHHW WHHHHH--YY P-EPVFFVVM MDDDHHFFPL LRWWVERRRG GPPPQQ---- -----LLAAW WHHHHH--YY D-LKFVVLLL LDDDGGFFVK KTWWKPGGGG GAAAPP---- -----MMGGY YQQQQQ--HH D-PKFVVLLL LDDDGGFFVK KTWWKPGGGG GEEEPP---- -----MMGGY YQQQQQ--HH D-SKFVVLLL LDDDGGFFVK KTWWQPGGGG GAAAPP---- -----MMGGY YQQQQQ--HH D-PKFVVLLL LDDDGGFFVK KTWWQPGGGG GAAAPP---- -----LLGGY YQQQQQ--HH D-VKFVVLLL LDDDGGFFVK KTWWRPGGGG GAAAPP---- -----SSGGY YQQQQQ--HH D-VKFVVLLL LDDDGGFFVK KTWWRPGGGG GAAAPP---- -----LLGGY YQQQQQ--HH D-VKFVVLLL LDDDGGFFVK KTWWRPGGGG GAAAPP---- -----LLGGY YQQQQQ--HH D-VKFVVLLL LDDDGGFFVK KTWWRPGGGG GAAAPP---- -----LLGGY YQQQQQ--HH D-PKFVVLLL LDDDGGFFVK KTWWRPGGGG GSSSPP---- -----MMGGY YQQQQQ--HH ---------- ---------- ---------- ---------- ---------- ---------- D-VKSLLVVL LLLLPPLLCS S--------- ---------- ---------- ---------- D-KAGFFLLL LLLLDDFFVK KRGGNRLLLF FPPPSS---- -----KKEEY YEEEEEYYWW D-PKFVVLLL LDDDGGFFVK KNWWAEGGGE EAAAPP---- -----FFGGY YQQQQQ--HH D-PKFVVLLL LDDDGGFFVK KNWWVEGGGE ESSSQQ---- -----FFGGY YQQQQQ--HH D-KEGFFLLL LLLLDDFFVK KRWWKPGGGH HSSSLL---- -----FFGGY YQQQQQ--HH D-KEGFFLLL LLLLDDFFVK KRWWKPGGGH HSSSLL---- -----FFGGY YQQQQQ--HH D-EKGFFLLL LLLLDDFFIK KRWWKPGGGH HSSSLL---- -----FFGGY YQQQQQ--HH D-EKGLLLLL LLLLDDFFIK KRWWKPDDDI ISSSLL---- -----YYGGY YQQQQQ--HH D-KAGFFLLL LLLLDDFFVK KRWWKPGGGH HSSSLL---- -----FFGGY YQQQQQ--HH E-ASFLLLLL LDDDGGFFPK KTWWADEEEK KTTTPP---- -----FFNNY YQQQQQ--RR E-ASFLLLLL LDDDGGFFPK KTWWADGGGK KVVVPP---- -----FFNNY YQQQQQ--RR ---------- ---------- ---------- ---------- ---------- ---------- D-AKDFFVVE EFFFDDFFLV VTWWRGDDDR RKKKLL---- -----CCGGY YQQQQQ--FF D-AKDFFIIL LFFFDDFFCI ITWWKGDDDK KKKKLL---- -----CCGGY YQQQQQ--FF E-SVGIIQQT TSSSKKNNLS SKGGASQQQF FEEEII---- -----LLQQN NNNNNN--RR D-DRLVVEEY YNNNDDEEVA AYWWPTAAAD DDDDQQAVVG DDAAAYYGGA ALLLLL--KK N-KRLVVEEY YTTTNNEEVA AHWWPTDDDG GDDDRRKTTG --KAAYYDDA ALLLLL--KK ELLVSSEEEW PN--TTIDDG -LLKLEEDRR YYYGGNRIHH FDDDDLRRII HHLGEEM--- GMMITTEEEW PR--CCFEEG -FFSLEEEAA YYYGGNKLHH VDDDDLARLL YYIGQEM--- DMMVSSEEEW PP--QQFNNG -IIVPEEAKK YYYGGHRLHH FDDDDLRRVV QQIGAQM--- DMMVTTEEEW PP--QQFNNG -IIVPEESKK YYYGGHRLHH FDDDDLRRVV QQIGANM--- DMMVSSEEEW PP--QQFNNG -IIVPEESKK YYYGGHKIHH FKKKKLRRVV QQIGANM--- DLLVTTEEEW PD--MMVDDG -LLVPDDGRR YYYGGRRLHH FDDDDLTRLL QQIGDEL--- DLLLTTEEEW PR--MMVSSG -VVLGDDAKK YYYGGHRLHH VDDDDLYRLL QQLGAEM--- DMMVTTEEEW PN--MMIGGG -LLDPQQNGG YYYGGRRLHH IDDDDLRRLL QQLGEEM--- NMMVSSEEEW PN--VVFDDG FNNPAHH-LL YYYGGSRIFF VDDDDWQHII QQLT--L--- NMMVSSEEEW PN--VVFDDG FNNPAHH-LL YYYGGSHIHH VDDDDWQHII QQLK--L--- NMMISSEEEW PN--VVFDDG FNNPADD-LL YYYGGSHLHH VDDDDWQHII QQLQ--L--- NMMISSEEEW PN--VVLDDG FNNPADD-LL YYYGGSHLYY VDDDDWQRVV QQLQ--L--- NMMISSEEEW PN--VVLDDG FNNPADD-LL YYYGGSHLYY VDDDDWQHVV QQLK--L--- NMMISSEEEW PN--VVLDDG FNNPADD-LL YYYGGSHLYY VDDDDWQHVV QQLK--L--- NMMISSEEEW PN--VVLDDG FNNPADD-LL YYYGGSHLYY VDDDDWQHVV QQLK--L--- NMMISSEEEW PN--VVLDDG FNNPADD-LL YYYGGSHLYY VDDDDWQHVV QQLK--L--- NMMISSEEEW PN--VVVNNG FNNPADD-LL YYYGGKHLHH VDDDDWQHVV QQLP--H--- ---------- ---------- ---------- ---------- ---------- ---------- ------IIIS SN--LLRTTG SRRDYPP-RR VVVAAGIT-- ---------- ---------- GFFWSSIIIQ SL--FFYTTG AEELMCC-GG VVVHHVISCC LNNNNYIRDD EELQ--ANNP NMMISSEEEW PK--AAFLLG FKKMEEE-MM YYYGGHSLNN VDDDDWTHII QQIGE-L--- NMMISSEEEW PK--AAFLLG FKKMEDD-HH YYYGGHSLNN VDDDDWTHVV QQIGK-L--- NMMISSSSSW PT--AAFKKG FDDLQHH-LL YYYGGRHLTT CQQQQLAGRR QQLGN-L--- NMMISSSSSW PK--AAFQQG FNNLQHH-LL YYYGGRHLHH VSSSSWPGKK QQLGD-L--- KMMISSSSSW PK--AAFKKG FDDLQHH-LL YYYGGSHLHH VSSSSWPGKK QQIGE-L--- KMMISSSSSW PK--AAFKKG FNNLQHH-LL YYYGGSHLHH VSSSSWPGKK QQIGP-L--- KMMISSSSSW PA--AAFTTG FDDLQHH-LL YYYGGRHLHH VDDDDWPGKK QQLGS-L--- NMMISSEEEW PN--HHIKKG FNNPAHH-LL YYYGGNSVHH IEEEEWDKLL QQIPQPA--- NMMISSEEEW PN--HHIKKG FNNPAHH-LL YYYGGNSVHH IEEEEWDKLL QQIPMPA--- ----SSLLLR PV--TTVRRD EEELKCC-LL VVVIIKCKRR V--------- ---------- NMMVAAEEEW PK--LLFRRG YHHPTDDRQQ YYYGGCRLNN FRRRRWQRFF QQIGD-L--- DMMVSSEEEW PN--KKWRRG WKKNVDDMQQ YYYGGCRLNN FKKKKWSQYY QQIGS-I--- ESSESSRRRP PI--MMAEES SEESFLLGLL KKKPPQHVAA ELLLL----- ---------- NMMLTTSSSF WSNNMMMFFG QMMLQDDMRR FFFGGNTIVV QDDDDLHRKK KKFPGA---- NLLVTTSSSF WNNNMMMFFG KMMLADDMHH FFFGGNTVVV TDDDDLHKKK KKFPGA---- ----LRRLHD TKMMFFVVVS LDDLSIWFYY AAAAKKVIEI PPPPPPLLGG G-NPEEELKK ----VRRLHD TKMMFFVVLN TDDLSIWFYY AAAARRVIDI EEPPPPFFGG G-PPPPPLKK ----VRRAHD VRYYFFVVVD TNNLEIWWRR VVVVKKTATI PPPPPPAAAA ADEPPPPLQQ ----VRRAHD VRYYFFVVVD TNNLEIWWRR AAAAKKTATI PPPPPPAAKK KEKPPPPLQQ ----IRRAHD SKYYFFVVVD TNNLQIFWQQ AAAAKKTITI DDPPPPAAAA ADDPDDDLKK ----LRRAHD TKYYFFVVIS LDDLSIWYRR VVVVKKVIEI PPAAAAAAPP PDQPPPPLKK ----LRRAHD TKYYFFVVVS LDDLSIWYRR LLLLKKVIDI PPPPPPAAEE EDQPPPPLKK ----LRRAHD ARYYFFVVVS LDDLSVWHRR IIIIKKVIEI PPPPPPAAPP PDQPPPPLKK ---LIRRLHD SAQQFFAALS SIIQRKNG-- -------TWS VVVVVVIIVV VPSKVVVGWW ---LIRRLHD DAQQFFAALS SIIQRKNG-- -------TWS VVVVVVIIVV VPSKVVVGWW ---LIRRLHN DAQQFFAALS SIIQRKNG-- -------TWS VVVVVVIIVV VPPKVVVGWW ---LIRRLHN DAQQFFAALS SIIQRKNG-- -------TWS AAVVVVIIVV VPPKVVVGWW ---LIRRLHN DAQQFFAALS SIIQRKNG-- -------TWS VVVVVVIIVV VPPKVVVGWW ---LIRRLHN DAQQFFAALS SIIQRKNG-- -------TWS VVVVVVIIVV VPPKVVVGWW ---LIRRLHN DAQQFFAALS SIIQRKNG-- -------TWS VVVVVVIIVV VPPKVVVGWW ---LIRRLHN DAQQFFAALS SIIQRKNG-- -------TWS VVVVVVIIVV VPPKVVVGWW ---LIRRLHD AAQQFFAALS SIIQRKNG-- -------TWS VVVVVVIIVV VPPKVVVGWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIILLRRIHW NIQQYYEEVS FGGRGDPY-- -------AVV LLKKKKLLLL LYYVVVVKFF ---LIRRLHD DAQQLLAALS SVVFRKEG-- -------KWA AAVVVVIIVV VPSKVVVGWW ---LIRRLHN DAQQLLAALS SIIFRKEG-- -------KWA AAVVVVIIVV VPSKVVVGWW ---LIRRLHD AKTTFFAALS SMMIRKTG-- -------SWS HHAAAAIIVV VKPKVVVNWW ---LIRRLHD AKTTFFAALT SMMIRKTG-- -------SWN HHVVVVIIVV VEPKVVVNWW ---LIRRLHD SKTTYYAALS SMMIRKND-- -------TWS YYVVVVIIVV VKPKVVVNWW ---LIRRLHD SKTTFFAALS SMMIRKNE-- -------TWS HHVVVVIIVV VKPKVVVNWW ---LVRRLHD SKTTYYAALT SMMVRKTG-- -------SWS HHAAAAIIII IKPKVVVNWW ---LVRRLHE TSHHFFAALG SIIFRPVNSS ----TT-THA AAVVVVAAII IPSKVVVGWW ---LVRRLHE TSHHFFAALG SIIFRPDNPP ----KK-VQT AAVVVVAAII IPSKVVVNWW ---------- ---------- ---------- ---------- ---------- ---------- ---LIRRLHN REQQYYAAFX XXXXX----- ---------- ---------- ---QGGGNGG ---LIRRLHN KKEEFFAALN AVVFHKKSDD ----EEFEAK KKDDDDIIGG GKLDTTTSGG ---------- ---------- ---------- ---------- ---------- ---------- ---LIRRPWG NAYYFFAALT SLLWLEDG-- ---------- --------WW WQAAVVVDII ---LIRRAWG AHYYFFAALT SLLWLEDG-- ---------- --------WW WQAAVVVDII FKKAAPLVDI IDLDDFFLSW IIIIGEVRRR YDISFLTTKK KVVIIFFRAD DDHP------ FKKMMPLVDI IDLDDFFVSW LLLLGELRRR YDITHLAARR RVVLLYYREP PPHP------ FGGAAPLVDI IDLDDFFVSW TTTTGEMRRR YDVSHLAASS SVVIIAARAP PPHP------ FGGAAPLVDI IDMDDFFVSW TTTTGEMRRR YDVSRLAASS SVVIIAARTP PPHP------ FGGAAPLVDI IDLDDYYVAW LLLLGEMHHH YDVSMLTTKK KVVIIVVKTP PPHP------ FKKAAPLVDI IDMDDFFVSW TTTTGDLLLL YDVSFLTTKK KVVIIVVRAT TTHPG----- FKKAAPLVDI INVDDFFVSW TTTTGELHHH YDVSFLTTKK KVVIIVVRAG GGHP------ FGGAAPLVDI INLDDFFVSW TTTTGELRRR YDVSFHTTSS SVVIIVVKAA AAHP------ LPPEEPLIDI ILLDDFFFSW HHHHGDIRRR YDISQLTTQQ QIISSIIRGG GGSVQ-DDEL LPPEEPLIDI ILLDDFFFSW HHHHGDIRRR YDISKLTTQQ QIISSIIKGG GGSVQ-DDEL LPPEEPLIDI ILLDDFFFSW HHHHGDLRRR YDISQLTTQQ QLLSSIIKGG GGPVQ-DDEL LPPEEPLIDI ILLDDFFFSW HHHHGDIRRR YDVSQLTTQQ QLLSSIIKDG GGPVQ-DDEL LPPEEPLIDI ILLDDFFFSW HHHHGDLRRR YDISQLTTQQ QLLSSIIKGG GGPVQ-DDEL LPPEEPLIDI ILLDDFFFSW HHHHGDLRRR YDISQL---- ---------- ---------- LPPEEPLI-- ---------- ---------- ---------- ---------- ---------- LPPEEPLIDI ILLDDFFFSW HHHHGDLRRR YDISQLTTQQ QLLSSIIKGG GGPVQ-DDEL LPPEEPLIDI ILLDDFFFNW HHHHGDMRRR YDISKLVVQQ QIISSIIKGG GGPVQ-DDEL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVSSSEFPA AWFSDLLFL- ---------- ---------- ---------- ---------- LPPEEPLIDI ILLDDFFFSW HHHHGDIRRR YDITRLVVQQ QIISSIIRGG GGPVT-DDDL MPPEEPLIDI ILLDDFFFSW HHHHGDIRRR YDITRLVVQQ QIISSIIRGG GGPVT-DDEL LPPEEPLIDF FLLDDFFFVW HHHHGDIRRR YNIEKLTTQQ QLLLLIIKGS SSPVA-EEGK LPPEEPLIDF FLLDDFFFVW HHHHGDIRRR YNIEKLTTQQ QVVLLIIKGS SSPVV-DDGE LPPEEPLIDF FLLDDFFFVW HHHHGDIRRR YNIEKLTTQQ QIILLLLKGS SSPVK-EEGN LPPEEPLIDF FLLDDFFFVW HHHHGDIRRR YNIEKLTTQQ QIILLLLKGS SSPVK-EEGN LPPEEPLIDF FVLDDYYLVW HHHHGDIRRR YNIEALAAQQ QVVLLLLKGS SSEVV-EEDK LPPEEPLIDI ILMDDFFVSW HHHHGDIRRR YDISLLNNQQ QVVSSVVTES SSNVK-GGK- LPPDDPLIDI ILMDDFFVSW HHHHGDIRRR YDISKLNNQQ QVVSSIISET TTTVK-EEHD ---------- ---------- ---------- ---------- ---------- ---------- IEEMMGMMDI ILLDDYYFSW HHHHGDVRRR YDISALTTQQ QVVAAIIRDA AAPRR-DDEL AEEDDGMIDI IILDDFFVNW HHHHGDVRRR YDITELTTQQ QLLAAIISDL LLPNVEDDEL ---------- ---------- ---------- ---------- ---------- ---------- NPPAAILPDI ISADDTTINF DDDDGKTRRR FDISHQIIEE EKKQQVV--- ---------- EPPAAVLPDI ISNDDRRVNF DDDDGKTRRR FDISHQVVEE EKKQQVV--- ---------- ---------- -----AAKKA AQQQMMMEIS SDDDDRRYYN NSSLLSSSSD DDNYEEGLGW ---------- -----SSEEA AQQQMMMSVS SDDDDRRYYN NSSLLSSSSN NNNY--GLGW ---------- -----NNTTG GQQQMMMEIS SDDDDRRYYN NSSLLSSSSD DDDYDDGVAA ---------- -----NNAAG GQQQMMMEIS SDDDDRRYYN NSSLLSSSSD DDDYDDGVGV ---------- -----NNTTG GQQQMMMEIS SDDDDKKYYN NSSLLSSSSD DDEYGGDRAA ---------- ----AKKAAG GQQQMMMEIS SDDDDRRYYN NSSLLGGGGD DDPYEEGIGW ---------- ----ATTEEG GQQQMMMEIS SDDDDRRYYN NSSLLRRRRD DDEYDDGIGW ---------- -----AAPPG GQQQMMMEVS SDDDDRRYYN NSSLLAAAAD DDEYVVGIGW LTCCCQQQPE PPLVVKKRRG GQQQMMMQLS SDDDDKKYYT TSSLLSSSSD DDKYPPDLRE LTCCCQQQPE PPLVVKKRRG GQQQMMMQLS SDDDDKKYYT TSSLLSSSSD DDKYPPNLRE LKSSSQQQPE PPLVVKKKKG GQQQMMMQLS SDDDDKKYYT TSSLLSSSSD DDKYPPDLRE LDSSSQQQPE PPLVVKKQQG GQQQMMMQLS SDDDDKKYYT TSSLLSSSSD DDKYPPDLRE LKSSSQQQPE PPLVVKKRRG GQQQMMMQLS SDDDDKKYYT TSSLLSSSSD DDKYPPDLRE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LKSSSQQQPE PPLVVKKRRG GQQQMMMQLS SDDDDKKYYT TSSLLSSSSD DDKYPPDLRE LKSSSQQQPE PPLVVKKRRG GQQQMMMQLS SDDDDKKYYT TSSLLSSSSD DDKYPPDLRE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LECCCQQQPD PPVIVKKKKG GQQQMMMQLS SDDDDKKYYN NSSLLSSSSD DDKYPPDMKE LECCCQQQPD PPVTVKKIIG GQQQMMMQLS SDDDDKKYYS SSSLLSSSSD DDKYPPDLKE KTWWWQQQSD VVPEIQQKKG GQQQMMMQLT TDDDDKKYYN NSSLLSSSSD DDKYPPGLEK ETWWWQQQSD VVPEIQQKKG GQQQMMMQLS SDDDDKKYYN NSSLLSSSSD DDKYPPKLEQ NSFFFQQQFD VVPQIKKSSG GQQQMMMQLS SDDDDKKYYN NSSLLSSSSD DDRYPPELDK NTFFFQQQFE VVPQIKKSSG GQQQMMMQLS SDDDDKKYYN NSSLLSSSSV VVVYPPEIEK KEEEEQQQYS VVPQVKKRRG GQQQMMMQLS SDDDDKKYYN NSSLLSSSSD DDEYQQDLKK -----PPPIE AALYVKKKKG GQQQMMMQLS SDDDDKKYYT TSSLLKKKKD DDDYPPEHKS D----EEEIP AALYVKKQQG GQQQMMMQLS SDDDDKKYYT TSSLLKKKKD DDDYPPENRS ---------- ---------G GAAAKKKQLS SDDDDKKYYN NSSFFSSSSD DDKYPPNVKE LKEEEAAAPE PPVFLKKRRG GQQQMMMQLS SDDDDRRYYS SSSLLSSSSD DDKYPPEMAA LKEEERRRPP AARYVKKRRG GQQQMMMQLS SDDDDKKYYS SSSLLSSSSD DDKYPPKMSQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMMSQS SDDDDKKYYS SSSLLAAAAD DD------KK ---------- ---------- ----MMMSSS SDDDDQQYYS SSSLLAAAAD DD------KK VLN--PPGLK EFFVDE---- ---SHHHHQQ VVRLLGGDDD SSSSSSSSCY ---------- AVN--PPGLK EFFVDR---- ---AHHHHQQ VVRLLGGDDD SSSSSSSTCY ---------- VAH--PPGLD DWWVEDGGG- ---AHHHHQQ IIRLLGGDDD SSSSSSSTCY SSVVVKRRRR VAN--GGGLK DFFVSDGGG- ---AHHHHQQ IIRLLGGDDD SSSSSSSTCY SSVVV----- VAN--EEGLK DWWVDAGGG- ---SHHHHQQ IIRLLGGDDD SSSSSSSTCY SSVVV----- VLD--PPGIP KFFLEKGGG- ---PHHHHQQ VVRLLGGDDD SSSSSSSSCY ---------- VVD--PPGMP NFFVDE---- ---VHHHHQQ IIRLLGGDDD SSSSSSSSCF ---------- AAE--PPGLP GFFTEDGGG- ---PHHHHQQ IIRLLGGDDD SSSSSSSSCY SS-------- SMLDDVVGLP NLLVDKEEEP LLPAHHHHEE LLRYYGGDDD SSSSSSSSI- ---------- SMLDDAAGLP NLLVDKEEEP LLPAHHHHEE LLRYYGGDDD SSSSSSSSI- ---------- SMLDDVVGLP NLLVDKEEEP LLPAHHHHEE LLRYYGGDDD SSSSSSSSL- ---------- SMLDDVVGLP NLLVDKEEEP LLPAHHHHEE LLRYYGGDDD SSSSSSSSL- ---------- SMLDDVVGLP NLLVDKEEEP LLPAHHHHEE LLRYYGGDDD SSSSSSSSI- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SMLDDVVGLP NLLVDKEEEP LLPAHHHHEE LLRYYGGDDD SSSSSSSSI- ---------- SMLDDVVGLP NLLVDKEEEP LLPAHHHHEE IIRYYGGDDD TTTTTTTSL- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SMLDDEEGLP NLLVDKEEEP GGPAHHHHEE LLRYYGGDDD SSSSSSSSV- ---------- AMLDDKKGLP NLLVDKEEEP DDPAHHHHEE IIRYYGGDDD TTTTTTTSI- ---------- SILDDEEGLP NFFVDAEEEP DDPAHHHHEE MMRYYGGDDD TTTTTTTSI- ---------- SILDDEEGLP NFFVDAEEEP DDPAHHHHEE MMRYYGGDDD TTTTTTTSI- ---------- SIIDDEEGLP NFFVDDEEEP EEPAHHHHEE MMRYYGGDDD TTTTTTTSI- ---------- SIIDDEEGLP DFFVDDEEEP DDPAHHHHEE MMRYYGGDDD TTTTTTTSI- ---------- SMLDDEEGLP NFFVDAEEEP EEPAHHHHEE MMRYYGGDDD TTTTTTTSI- ---------- AMVNDEEKMR DLLIDKIIIE GGPAHHHHEE MMRYYGGDDD TTTTTTTSI- ---------- AMLDDIIHMK NLLIDKVVVP GGPAHHHHEE MMRYYGGDDD TTTTTTTSI- ---------- SMLDDEEGLK NLLVDKEEEP NNPAHHHHDD IIRFFCGDDD TTTTTTTSA- ---------- GIVDDEEGME NLLVDGEEEP YYPPHHHHEE MMR------- ---------- ---------- GIVDDVVGIE DLLVDNEEEP YYPPHHHHEE MMRYYGGDDD TTTTTTTSLA DDAAA----- ---------- ---------- ---------- ---------- ---------- ---------- KDALANNGKE DAAVDELLLG LL-AHHHHII MMRFFSSAAA YYYYYYYS-- ---------- KDELLYYGKE QAAIDAEEEK LL-PHHHHQQ MMRFFARAAA YYYYYYYAGD NNRRRLVVVV ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QRVVVVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMSAAAKKKA AKKKKQPSSE AATPCCTAVV PPTTGLLAAR RRLGAAMQQL LPPPRTTLSL gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TTSPVVVRQQ AAATSSSAVV LLSSSPRRSK GRKSSSPGGG VVSAKQVVVV VSAAWWHWLP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MGLG ---------- ---------- ---------- ---------- ---------- ----LLKNSQ ---------- ---------- ---------- ---------- ---------- ---------- --------AA RSSPLLPPNN RRTTTPHHPL APAPPPPRRR PPRVYRTTTT IVRRCCPHAR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MK ---------- ---------- ---------- ---------- ---------- --------MK ---------- ---------- -----MAIVF FFRPPTFPPP KKMAMKKAAP PPPPPPPPDD ---------- ---------- -------MAL LLPPPTFPPP RRDAMRRAAP PPPPPPPPDD ---------- ---------- --------MM MMPPPTFAAP EELAMQQAAP PPPPAAAAEE ---------- ---------- --------MM MMPPPTFAAP KKLAMEEAAP PPPPAAAANN ---------- ---------- --------ML LLPPPTFPPA KKLAMEEGGP PPPPVVVVKK ---------- ---------- -------MAW WWPPPSFPPP RRLAAKKAAP PPPPPPPPTT ---------- ---------- -------MVW WWPPPTFPPP RRMAVKKAAP PPPPAAAAKK ---------- ---------- -------MAW WWPPPTFPPP KKMAMQQAAP PPPPRRRRRR ---------- ---------- ----ATKCT- --CPPGYTTL EEAMK--GGP PPPPRRRREE ---------- ---------- ---------- ---------- ----M--GGP PPPPRRRREE PPPPPPGGHG GAVVAAGLPP G-AASTQCG- --CPPGYSSL EEAMK--GGP PPPPRRRREE ---------- ---------- ---------- ---------- ---MK--GGP PPPPRRRREE ---------- ---------- ----ATKCG- --CPPGYTTL EEAMK--GGP PPPPRRRREE AAAEEERREG GFTTAAPMPP IASSATKCG- --CPPGYTTL EEAMK--GGP PPPPRRRREE ---------- ---------- ----ATKCG- --CPPGYTTL EEAMK--GG- ---------- ---------- ---------- ----ATKCG- --CPPGYTTL EEAMK--GGP PPPPRRRREE GGGKKKEEPG GTAALLGQWW QEDDATKCG- --CPPGYTTQ EEAMK--GGP PPPPRRRREE QQQGGGCCGF FQTTHHYCLL VFTTPTKCG- --CPPGYTTL EEAMK--GGP PPPPRRRREE ---------- ---------- ----ATKCG- --CPPGYTTL EEAMK--GGP PPPPRRRREE RRRHHHSSVL LHIIAAVEAA AAAAGKTCCT TTKPPGYTTL EEAMEKKGGP PPPPRRRRKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MAKCG- --CPPGYSSL DDAMK--GGP PPPPRRRREE ---------- ----LLHGVV NEKKS-VNGC CCSPPGYSSI EESMS--GGP PPPPRRRRSS ---------- ----LLHAVV SEKKNNQQGC CCSPPGYSSL EEAMS--GGP PPPPRRRRTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------RMQ QQGPPGYTTL AAAMS--GGP PPPPSSSSKK ---------- --------AA AAAAGAACCG GGTPPGYTTL EEAMEKKGGP PPPPRRRRKK ---------- --------MM SPNNGLKCH- ---PPGYSSA DDAIK--GGP PPPPRRRREE ---------- --------MM P---PLKCH- ---PPGYSSA DDAIK--GGP PPPPRRRREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MSESC CCCPPGYTTL DDAVRNNGGP PPPPVVVVKK ---------- ---------- ---------- ---------- ---MRSSGGP PPPPRRRRKK ---------- ---------- ---------- ---PPGLTT- DDILISSLLD DDDDDDDDFF KKKRRRRRFG G-----ALAA G-AAAMGLPR RRFDDETQQP YYMPKIITTG GGGGQQQQEE KKKRRRFFVS SPSSLLALSS GLAAALAAPG GGRDDETAAP YYMKKIITTG GGGGQQQQDD AAAAACLYTG TINRRDDAAV VVPKKSKVHK KVVVEPNDEE ELLHHHFFGG NAAASSSLLC AAAAAALYVG TVNAADDAAV VVPKKSKIYK KLLLDPGDEE ELLHHHFFGG NAAASSSYYC AALLLLLSPD F--RRDDAAV VIPGGSKVHT TVVVTPGDEE EFFHHHFFGG NAAASSSLLS AALLLLLSPD F--KKDDAAV VIPGGSQVHT TVVVTPGDEE EFFHHHFFGG NAAASSSLLS AALLLMLSPD A--KKDDAAV VVPTTSQVHQ QLLLIPGDEE EFFHHHFFGG NAAASSSLLS AAAAAMFDPE R--QQDDAAV VVPAASSVGQ QVVVAPGDEE ELLHHHFFGG NAAASSSLLC AAVVVRLNPM AG-KKDDCCV VVSQQSQVGV VTTTDPGGEE ELLHHHFFGG NAAASSSLLC GGAAALLDPG R--RRDDGGV VLPDDSQVGR RVVVEPADEE ELLHHHFFGG NAAASAALLC VVPPPCIYRN TTEAADDAAT TVPKKSQIHR RLLLPPKDEE ELLHHHSSGG NTTTSSS--- VVPPPCIYRN TIEAADDAAT TVPKKSQIHR RLLLPPKDEE ELLHHHSSGG NTTTSSS--- VVPPPCIYGN TIEAADDAAT TVPKKSQIHR RLLLPPRDEE ELLHHHSSGG NAAASSS--- IIPPPCIYRN TIEAADDAAT TVPKKSQIHR RLLLPPKDEE ELLHHHSSGG NTTTSSS--- VVPPPCIYRN TTEAADDAAT TVPKKSQIHR RLLLPPKDEE ELLHHHSSGG NTTTSSS--- VVPPPCIYRN TTEAADDAAT TVPKKSQIE- ---------- ---------- ---------- ---------- -TEAADDAAT TVPKKSQIHR RLLLPPKDEE ELLHHHSSGG NTTTSSS--- VVPPPCIYRN TTEAADDAAT TVPKKSQIHR RLLLPPKDEE ELLHHHSSGG NTTTSSS--- VVPPPCIYRN TTEAADDAAT TVPKKSQIHR RLLLPPKDEE ELLHHHSSGG NTTTSSS--- VVPPPCIYRN TTEAADDAAT TVPKKSQIHR RLLLPPKDEE ELLHHHSSGG NTTTSSS--- VVPPPCIYRN TTEAADDAAT TVPKKSQIHR RLLLPPKDEE ELLHHHSSGG NTTTSSS--- VVTTTCVYNG TINKKDDAAT TVPSSSQIHR RLLLPIGDKK KLLHHHSSGG NSSSSSS--- ---------- ---------- ---------- -----PNDEE ELLHHHSSGG NTTTSSS--- VVPPPCIYRS TINKKDDAAT TVPKKSQIHR RLLLPPNDEE ELLHHHSSGG NTTTSSS--- IITTTAVYAG TIEKKDDAAT TVPSSSKIHR RLLLPPGDEE ELLHHHTTGG NSSSSSS--- IITTTAVYAG TIEKKDDAAT TVPNNSKIHR RLLLPPGDEE ELLHHHTTGG NSSSSSS--- ---------- ---------- ---------- -----PGDEE ELLHHHSSGG NSSSSSS--- IITTTAVYTG TIDKKDDAAT TVPSSSSIHR RLLLPPGDEE ELLHHHSSGG NSSSSSS--- LLTTTCVYNG TINKKDDGGT TVPNNSQIHR RLLLPTGDEE ELLHHHSSGG NAAASSS--- LLTTTAP--- NADGGDDFFT TVPEESQISR RVVVDPGDEE EVVHHHTTGG NAAASSS--- LLTTTAP--- HRDGGDDFFT TVPEESQISR RVVVDPGDEE EVVHHHTTGG NAAASSS--- ---------- ---------- ---------- ---------- ---------- ---------- LLVVVCVQPN LEEHHDDAAT TVPAASQIHR RTTTYNHNEE ELLHHHSSGG NTTTSSSHHF LLVVVTVQPN LEPHHDDSST TVPEESQVHR RTTTFNGDEE ELLHHHSSGG NAAASSSYYY YYNNNWLHGD IQYDDTTKKN NPGQQVSLKD DGGGPKEDKK KEELLDSSQQ TPPPILL--- VVWWWTLGVE GGDEEDDVVT TIPGGSQINS SVVVSGRNEE EAAHHHGGGG SAAA------ VVWWWTLGAE GGDEEDDVVT TVPKKSKVNT TLLLSGRNEE EAAHHHSSDD TDDD------ CPGKPNERRF LIVPSRRIII IIIDDTKNPP EPKKKKKIII KVVIIEPEEE EEEEKKKKSS CPAKPFERRY LIVPSRRIVV VVVDDTKDKK RPAAAAAVAA KIIVVEPEEV VVVVVVVGTT SPTHAFERRF LIIPSRRVII IIIDDTKHPP QARRRRRIHH KIIIIEPDDE EEEELLLATT SPAHAFERRY LIIPSRRIII IIIDDTKDPP KAKKKKKIHH KIIIIEPEEE EEEEFFFKTT SPTHAFERRY LIIPSRRIVV VVVDDVKEPP KAKKKKKIHH KIIIIEPEEE EEEEFFFATT CPAHPHERRY LVVPSRRILL LLLDDTKDPP KPFFFFFLAA KVVIIEPEET TTTTAAAETT CPAHPHERRY LVVPSHHILL LLLDDTKDPP QPKKKKKVVV KVVIIDPNNE EEEEAAAETT CPAHPHERRY LIVPSRRIVV VVVDDTKDPP EPRRRRRIVV KVVIIEPEEE EEEEHHHRTT --FDSTSNNK LILPSRRVVV VVVDDVGEPP APKKKKKLHH KVVIIEASSE EEEEQQQACC --FDSTSDDK LILPSRRVVV VVVDDVGEPP APKKKKKLHH KVVIIEPNNE EEEEHHHACC --FDSTSTTK LMLPSRRVVV VVVDDVGDPP APKKKKKLHH KVVIIEAEED DDDDHHHACC --YDITATTK LVLPSRRVVV VVVDDVGEPP APKKKKKLHH KVVIIEPKKD DDDDHHHTCC --FDSTSTTK LVLPSRRVVV VVVDDVGEPP APKKKKKLHH KVVIIEPEED DDDDHHHACC ---------- ---------- ---------- ---------- ------PKKD DDDDHHHACC --FDSTSTTK LVLPSRRVVV VVVDDVGEPP APKKKKKLHH KVVIIEPKKD DDDDHHHACC --FDSTSTTK LVLPSRRVVV VVVDDVGEPP APKKKKKLHH KVVIIEPKKD DDDDHHHACC --FDSTSNNK LVLPSRRVVV VVVDDVGEPP APKKKKKLHH KVVIIEAKKD DDDDHHHECC --FDSTSTTK LVLP------ ---------- ---------- ---------- ---------- --FDSTSTTK LVLPSRRVVV VVVDDVGEPP APKKKKKLHH KVVIIEPKKD DDDDHHHACC --HDPSKRRF LILPSRRVVV VVVDDTADPP TPSSSSSLHH KVVVVESEED DDDDAAAEII --YDASVNNK LILPSRRVVV VVVDDVGDPP APRRRRRIHH KTTVVEPYYE EEEEFFFWCC --YDSSVNNK LILPSRRVVV VVVDDVGDPP APRRRRRIHH KTTVVEPYYE EEEEFFFWCC --HDPSERRF LIAPSRRVII IIIDDTKNPP SPSSSSSLHH KVVVVDPAAD DDDDIIIQTT --HDPSQRRF LIVPSRRVII IIIDDTKNPP APSSSSSLHH KVVVVEPEED DDDDSSSTTT --HDASDRRY LVLPSRRAII IIIDDTKNPP APSSSSSLYY KYYVVDPKKE EEEEAAAETT --HDASDRRY LVLPSRRAII IIIDDTKNPP APSSSSSLYY KYYVVDPKKE EEEEAAADTT --HDPSSRRF LILPSRRVVV VVVDDTLDPP APAAAAALHH KVVVVEAEED DDDDAAAETT --HKPTKSSH LIVPSRRIII IIINNVEE-- KIYYYYYLEE HTTIIEPSSK KKKKHHHSNN --HKPTKSSH LIVPSRRVII IIINNVEE-- EIYYYYYLQQ HTTIIEPSSK KKKKHHHANN ---------- MVPRSVVKVV VVVFFVG--- ---------- ---------- ---------- FPGKEVTDDR LVLPSRRVII IIIDDTGDPP APKKKKKLAA KVVIIEG--D DDDDLLLKAA YDSKTVKDDR LVLPSFFILL LLLDDVVDPP KPEEEEEIVV KTTIIDG--D DDDDLLLKHH ---KRVGPPQ MLQLGRRVTT TTTTTSLSAA DKQQQQQFYY P--------D DDDDIIIKLL ------DRRF FWTGTRRIFF FFFDDVHDPP NPKKKKKLHH KTTIIDT--F FFFFKKKDGG ------DRRY LWAGTKKVFF FFFDDVHDPP RPVVVVVLSS KTTIITD--F FFFFEEEKGG GYSRLLHVVH HGPYYIIISL GGNE--EE-- EEGLLDHSFF EEPLGGIIRY ---------- GYTKYYHVVH HGPYYIIISL GGGP--DDRR EEGFLDHTFF EEPIGGVVRY ---------- GYSRPPHVVH HGPYYVVVSL GGGAGKDDTT DDPFMDCTFF DDVLGGIIRD ---------- GYSRPPHIIH HGPYYVVVSL GGGGGKDDTT NNPFMDCTFF EEVLGGIIRT ---------- GYSRPPHIIH HGPYYVVVSL GGGGGEDDTT DDPFLDCTFF EEILGGMMRT ---------- GYSRPPHVVH HGPYYVVVTL GGNA--EE-- KKGALDASFF EEPLGGVVRY ---------- GYARPPHVVH HGPYYIIISL GGSP--EE-- EEGFLDHNLL EEVLGGIIRY ---------- GYSRPPHIIH HGPYYVVVSL GGSP--EE-- DDGFMDHSFF DDPLGGVVRQ ---------- NVSNTTHSSH HLAVVMMMVT LLGD--LLGG NNGVLDGTFF EEVKGGKKGP ---------- NLGNLLHSSH HLAVVMMMIS LLGD--PPGG NNGVLDGTFF EEVKGGKKGP ---------- GLGYVVHSSH HLAVVMMMIT LLGD--SSGG NNGVLDGTFF EEVKGGQQGP ---------- NLGFFFHSSH HLPVVMMMVT LLGD--PPGG NNGVLDGTFF EEVKGGQQGP ---------- ELAFLLHSSH HLAVVMMMIS LLGD--VVGG NNGVLDGTFF EEVKGGRRGP ---------- ELAFLLHSSH HLAVVMMMIS LLGD--VVGG NNGVLDGTFF EEVKGGRRGP ---------- ELAFLLHSSH HLAVVMMMIS LLGD--VVGG NNGVLDGTFF EEVKGGRRGP ---------- ELAFLLHSSH HLAVVMMMIS LLGD--VVGG NNGVLDGTFF EEVKGGRRGP ---------- GLGTPPHSSH HLPVVMMMIT LLGD--PPGG NNGVLDGTFF EEVKGGRRGP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ELAFLLHSSH HLAVVMMMIS LLGD--VVGG NNDLLLPRLL EECSGG---- ---------- GLGFPPHSSH HLAIIMMMIC LLGD--KKGG NNGFLLDEFF NNVKGGNNLS ---------- GLANLLHSSH HLGIIMMMIS IIGD--PPGG NNGVLDGTFF EEVKGGAAGP ---------- GLANPPHSSH HLGIIMMMIS LLGD--PPGG NNGVLDGTFF EEVKGGVVGQ ---------- GLAYPPHSSH HLALLMMMIC LLGD--KKGG NNGFLLDDFF NNVKGGKKGL ---------- GLAYPPHSSH HLAIIMMMIC IIGD--KKGG NNGFLLDEFF NNVKGGKKGL ---------- GLAYPPHAAH HLAIILLLVC LLGD--EEGG NNGFLLDDFF NNIKNNKKGL ---------- GLAFPPHAAH HRTIILLLVC LLGD--EEGG NNGLLLDDFF NNIKNNKKDL ---------- GLGFPPHSSH HLAIIMMMIC LLGD--KKGG NNGFLLDEFF NNVKGGKKGL ---------- -LSFPPHSSH HLAIIMMMIT LLGE--AAGG TTGLLDGTFF EEPKGGAAEP ---------- -LSFPPHSSH HLAIIMMMIT LLGE--AAGG SSGLLDGTFF EEPKGGAAGP ---------- ---------- ---------- ---------- ---------- ---------- ---------- DCTAPPHTTH HLPIIMMMII MMGD--AAGG NNGFEFDNFF EELVGGRRDL ---------- NVTAPPHTTH HLAIIMMMIV MMGD--AAGG YYGFLFDDFF NNCIGGKKDL ---------- VLAISSHAAD DQPLLKKKQG VVNE--SSSS VVLITSKENN GGLSAAAAQI ---------- GVVGPPHFFF FLPMMIIITL SSND--DDHH GGTVYNDGEE YYVATTPPAQ GGAAVAADAD GVVGPPHLLY YLPLLIIITL SSNN--KKHH GGTVYTNGEE YYVATTPPDR GGAAIKK-KD --LAYDFWWN LEVVVEWAV- ---TIEEE-L LKHLL--RYY GGNNRRFWWL LLRKRRRRII --FAYDFWWN LGVVIEWTV- ---CFEEE-F FSCLLGGAYY GGNNKKVWWL LLAKRHHHLL --KHYDFWWN LDYYVEWAL- ---QFEEE-I IVDLLNNKYY GGHHRRFWWL LLRARNNNVV --LHYDFWWN LDYYVEWAL- ---QFEEE-I IVDLLNNKYY GGHHRRFWWL LLRARNNNVV --KHYDFWWN LDYYVEWGL- ---QFEEE-I IVDLLNNKYY GGHHKKFWWL LLRDRNNNVV --FAYDGWWH LDTTVEWGT- ---MVEEE-L LVILLAARYY GGRRRRFWWL LLTRRHHHLL --LHYDFWWH LDTTLEWGT- ---MVEEE-V VLELLGGKYY GGHHRRVWWL LLYRRHHHLL --LAYDFWWH LDTTVEWGT- ---MIEEE-L LDILLKKGYY GGRRRRIWWL LLRRRHHHLL --MGYDFWYQ PNVVVEWAA- ---VFKKKFN NPVEEGGLYY GGSSRRVWWW WWQRHIIIII --MGYDFWYQ PNIIVEWAA- ---VFKKKFN NPVEEGGLYY GGSSHHVWWW WWQRHIIIII --MGYDFWYQ PNVVIEWAA- ---VFRRRFN NPVEEGGLYY GGSSHHVWWW WWQRHIIIII --LGYDFWYQ PNVVIEWAA- ---VLRRRFN NPVKKGGLYY GGSSHHVWWW WWQRRIIIVV --SGYDFWYQ PNVVIEWAA- ---VLRRRFN NPVEEGGLYY GGSSHHVWWW WWQHHIIIVV --LGYDFWYQ PNVVIEWAA- ---VLRRRFN NPVEEGGLYY GGSSHHVWWW WWQRHIIIVV --LGYDFWYQ PNVVIEWAA- ---VLRRRFN NPVEEGGLYY GGSSHHVWWW WWQRHIIIVV --LGYDFWYQ PNVVIEWAA- ---VLRRRFN NPVEEGGLYY GGSSHHVWWW WWQRHIIIVV --MGYDFWYQ PNVVIEWAA- ---VVQQQFN NPVEEGGLYY GGKKHHVWWW WWQRHIIIVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----ISAH- ---LRLLLSR RDASSSSRVV AAGGII---- ---------- --KERTHLYE NGLLWIQCC- ---FYTTTAE ELLTTSSGVV HHVVIILDDY YYIMRIIIDD --FGYDFWYQ PNVVIEWGA- ---AFAAAFK KMVQQGGMYY GGHHSSVWWW WWTEHRRRII --FGYDFWYQ PNVVIEWGA- ---AFAAAFK KMVQQGGHYY GGHHSSVWWW WWTEHLLLVV --FGYDFWYQ PNTTISWGA- ---AFTTTFD DLVAAGGLYY GGRRHHCIIL LLARGLLLRR --FGYDFWYQ PNTTISWGA- ---AFLLLFN NLVAAGGLYY GGRRHHVYYW WWPGGIIIKK --FGYDFWYQ PKTTISWGA- ---AFSSSFD DLVAAGGLYY GGSSHHVYYW WWPGGMMMKK --YGYHFWYQ PKTTISWGA- ---AFSSSFN NLVAAGGLYY GGSSHHVYYW WWPGGIIIKK --FGYDYWYQ PKTTISWGA- ---AFRRRFD DLVQQGGLYY GGRRHHVYYW WWPGGLLLKK --FNYDFWYQ PNVVIEWGS- ---HIKKKFN NPVGGGGLYY GGNNSSIFFW WWDSKYYYLL --FNYDFWYQ PNIIIEWGS- ---HIKKKFN NPVPPGGLYY GGNNSSIFFW WWDTKHHHLL ---------- -----LRGG- ---TVCCCEE ELQPPPPLVV IIKKCCVYY- ---------- --CGYDYWYQ PNVVVEWGA- ---LFRRRYH HPCDDTTQYY GGCCRRFYYW WWQERLLLFF --CGYDFWYQ PDVVVEWGA- ---KWRRRWK KNLEESSQYY GGCCRRFYYW WWSTQLLLYY --LQLSNHNN GEKKERPDE- ---MAFFFSE ESKKKPPLKK PPQQHHEVV- ---------- GGYGYDIRAL INVVLSFTGN YYYMMDDDQM MLAEEKKRFF GGNNTTQWWL LLHTRPPPKK GGYDYDVRAL PNLLVSFTGN YYYMMDDDKM MLPEEKKHFF GGNNTTTWWL LLHTKPPPKK ISSTTLEENA L----LLRRL HDDPTTMGGF FIMMVSLLSS SSSSIIIWWW LWWEEWWNNA LAADDLEEHV L----VVRRL HDDPTTMGGF FVVVLNTTSS SSSSIIIWWW LWWEEWWQQA VTTDDLQQHA L----VVRRA HDDPVVYGGF FVVVVDTTEE EGGSIIIWWW TWWEEFFHHV VTTDDLNNHA L----VVRRA HDDPVVYGGF FVVVVDTTEE EAASIIIWWW TWWEEFFHHA VTTDDLNNHA L----IIRRA HDDPSSYGGF FCVVVDTTQQ QGGAIIIFFF TWWDDFFEEA LEEDDFEEHV F----LLRRA HDDPTTYGGF FVCCISLLSS SSSSIIIWWW TWWDDWWAAV LTTDDLEEYA L----LLRRA HDDPTTYGGF FMCCVSLLSS SAASIIIWWW LWWDDWWHHL LAADDVEEHV L----LLRRA HDDPAAYGGF FVVVVSLLSS SAASVVVWWW LWWQQWWGGI ITTQQM--DI P---LIIRRL HDDPSSQGGF FVCCLSSSRR RFFYKKKNNN EEE------- ITTQQM--DI P---LIIRRL HDDPDDQGGF FVCCLSSSRR RFFYKKKNNN EGG------- ITTTTL--DI P---LIIRRL HNNPDDQGGF FVCCLSSSRR RFFYKKKNNN QGG------- VTTPPL--DI P---LIIRRL HNNPDDQGGF FVCCLSSSRR RFFFKKKNNN EDD------- VTTSSL--DI P---LIIRRL HNNPDDQGGF FVCCLSSSRR RFFYKKKNNN EGG------- VTTSSL--DI P---LIIRRL HNNPDDQGGF FVCCLSSSRR RFFYKKKNNN EGG------- VTTSSL--DI P---LIIRRL HNNPDDQGGF FVCCLSSSRR RFFYKKKNNN EGG------- VTTSSL--DI P---LIIRRL HNNPDDQGGF FVCCLSSSRR RFFYKKKNNN EGG------- VTTLLM--DI P---LIIRRL HDDPAAQGGF FVCCLSSSRR RFFYKKKNNN EGG------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DSSPPL--DG ANPPLLLRRI HWWKNNQDDY YDVVVSFFGG GGGSDDDPPP DAA------- ITTDDL--DI P---LIIRRL HDDPDDQGGL LVCCLSSSRR RFFYKKKEEE KDD------- VTTDDL--DI P---LIIRRL HNNPDDQGGL LVCCLSSSRR RFFYKKKEEE KDD------- RTTDDL--TL P---LIIRRL HDDPAATGGF FVSSLSSSRR RFFFKKKTTT QDD------- KTTDDL--KL P---LIIRRL HDDPAATGGF FVSSLTSSRR RFFFKKKTTT QDD------- KLLDDL--TL P---LIIRRL HDDPSSTGGY YVSSLSSSRR RFFFKKKNNN SDD------- KLLDDL--TL P---LIIRRL HDDPSSTGGF FVSSLSSSRR RFFFKKKNNN SDD------- KTTDDL--TL P---LVVRRL HDDPSSTGGY YVCCLTSSRR RFFFKKKTTT ADD------- LTTDDLPPLL P---LVVRRL HEEPTTHAAF FVCCLGSSRR RIIHPPPVVV EEE------- LTTDDLPPRL P---LVVRRL HEEPTTHAAF FVCCLGSSRR RIIHPPPDDD EKK------- ---------- ---------- ---------- ---------- ---------- ---------- FTTDDL--DT P---LIIRRL HNNPRRQGGY YVCCFXXXXX XXXX------ ---------- YTTDDL--DT P---LIIRRL HNNPKKEGGF FVCCLNAAHH HFFKKKKKKK SDD------- ---------- ---------- ---------- ---------- ---------- ---------- KVVNNVAAP- ----LIIRRP WGGSNNYAAF FSTTLTSSLL LIIYEEEDDD DAA------- KVVDDVAAP- ----LIIRRA WGGEAAYCCF FTTTLTSSLL LIIYEEEDDD GEE------- AAAEEKKVVI IPELEGG--- --NLEIIILL KKFFKPPDDD DDDIDDDFLS WWGIIGGGEQ AAAEERRVVI IEQFEGG--- --PLPVVVLL KKFFKPPDDD DDDIDDDFVS WWGLLGGGEQ VVVKKKKTTA IPEATAADDD DDELPLLLLL QQFFGPPDDD DDDLDDDFVS WWGTTGGGEQ AAAEEKKTTA IPEAPKKEEE EEKLPLLLLL QQFFGPPDDD DDDLDDDFVS WWGTTGGGEQ AAAKKKKTTI IDVADAADDD DDDLDLLLLL KKFFGPPDDD DDDLDDDYVA WWGLLGGGEQ VVVRRKKVVI IPEADPPDDD DDQLPVVVLL KKFFKPPDDD DDDLDDDFVS WWGTTGGGDQ LLLKKKKVVI IPEASEEDDD DDQLPIIILL KKFFKPPDDD DNNLDDDFVS WWGTTGGGEQ IIIRRKKVVI IPEAEPPDDD DDQLPLLLLL KKFFGPPDDD DNNLDDDFVS WWGTTGGGEQ ---------T SVKIQVVPPP PPSKVKKKGG WWLLPGGDDD DLLLDDDFFS WWLHHGGGDQ ---------T SVKIQVVPPP PPSKVKKKGG WWLLPGGDDD DLLLDDDFFS WWLHHGGGDQ ---------T SVKIQVVPPP PPPKVKKKGG WWLLPGGDDD DLLLDDDFFS WWLHHGGGDQ ---------T SAKIQVVPPP PPPKVKKKGG WWLLPGGDDD DLLLDDDFFS WWLHHGGGDQ ---------T SVKIQVVPPP PPPKVKKKGG WWLLPGGDDD DLLLDDDFFS WWLHHGGGDQ ---------T SVKIQVVPPP PPPKVKKKGG WWLLPGGDDD DLLLDDDFFS WWLHHGGGDQ ---------T SVKIQVVPPP PPPKVKKKGG WWLLPGG--- ---------- ---------- ---------T SVKIQVVPPP PPPKVKKKGG WWLLPGGDDD DLLLDDDFFS WWLHHGGGDQ ---------T SVKIEVVPPP PPPKVKKKGG WWLLPGGDDD DLLLDDDFFN WWLHHGGGDQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A VLRLDLLYYY YYYAVAAAKK FFVVVNNPPP PWWISSDLFL ---------- ---------K AAKIKVVPPP PPSKVEEEGG WWLLPGGDDD DLLIDDDFFS WWLHHGGGDQ ---------K AAKIQVVPPP PPSKVEEEGG WWMMPGGDDD DLLIDDDFFS WWLHHGGGDQ ---------S SHLIPVVKKK KKPLVQQQNN WWLLPGGDDD DLLIDDDFFV WWLHHGGGDQ ---------S NHIISVVEEE EEPLVQQQNN WWLLPGGDDD DLLIDDDFFV WWLHHGGGDQ ---------T SYIISVVKKK KKPLVEEENN WWLLPGGDDD DLLIDDDFFV WWLHHGGGDQ ---------T SHVISVVKKK KKPLVEEENN WWLLPGGDDD DLLIDDDFFV WWLHHGGGDQ ---------S SHVISIIKKK KKPLVRRRNN WWLLPGGDDD DVVIDDDYLV WWLHHGGGDQ -----TT--T AALAFIIPPP PPSKVSSSGG WWLLPAADDD DLLIDDDFVS WWLHHGGGDQ -----KK--V TALATIIPPP PPSKVEEENN WWLLPAADDD DLLIDDDFVS WWLHHGGGDQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----GEEENN GGIIEGGDDD DLLIDDDYFS WWRHHGGGDQ -----EEFFE KKIIPGGKKK KKLVTGGGSS GGAAEGGDDD DIIIDDDFVN WWRHHGGGDQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----EWWQQQ QQAKVAAADD IINNPPPDDD DSSIDDDTIN FFMDDGGGKL ---------- ----EWWQQQ QQAKVAAADD IIEEPPPDDD DSSIDDDRVN FFMDDGGGKL QYYYPPFVVT KKKLGGIIRA ---------- --------LL GPPPLLESSR DGGRRYYVYY QYYYPPHRRA RRRIGGLLRE ---------- --------AA GPPPIISSSR DGGRRYYIYY QYYYPPHVVA SSSIGGIIRA ---------- --------FF GPPPVVESSR DGGRRYYWYY QYYYPPRKKA SSSIGGIIRT ---------- --------FF APPPVVESSR DGGRRYYWYY QYYYPPMVVT KKKIGGIIKT ---------- --------FF YPPPVVESSR DGGKKYYWYY QYYYPPFKKT KKKIGGIIRA G--------- --------LL GPPPVVESSR DGGRRYYFYY QYYYPPFRRT KKKIGGIIRA ---------- --------LL GPPPVVESSR DGGRRYYFYY QYYYPPFRRT SSSLGGIIKA ---------- --------LL GPPPVVESSR DGGRRYYFYY QYYYPPQRRT QQQLGGSSRG QVVVLDETCC CPPPPPEPII GPPPIIQSSL DGGKKYYAYY QYYYPPKRRT QQQLGGSSKG QVVVLDETCC CPPPPPEPVV GPPPIIQSSL DGGKKYYVYY QYYYPPQRRT QQQLGGSSKG QVVVLDEKSS SPPPPPEPVV GPPPIIQSSL DGGKKYYVYY QYYYPPQRRT QQQLGGSSKD QVVVLDEDSS SPPPPPEPVV GPPPIIQSSL DGGKKYYVYY QYYYPPQRRT QQQLGGSSKG QVVVLDEKSS SPPPPPEPVV GPPPIIQSSL DGGKKYYIYY QYYYPPQRR- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QYYYPPQRRT QQQLGGSSKG QVVVLDEKSS SPPPPPEPVV GPPPIIQSSL DGGKKYYIYY QYYYPPKRRV QQQLGGSSKG QVVVLDEKSS SPPPPPEPVV GPPPIIQSSL DGGKKYYVYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QYYYPPRKKV QQQLGGSSRG TVVVLDDECC CPPPPPDPVV GPPPIIQSSL DGGKKYYVYY QYYYTTRKKV QQQLGGSSRG TVVVLDEECC CPPPPPDPII GPPPIIQSSL DGGKKYYVYY QYYYLLKVVT QQQVGGLLKG AAAAIEGTWW WSSSSSDVLL GPPPIIQTTL DGGKKYYVFF QYYYVVKKKT QQQAGGLLKG VAAAVDGTWW WSSSSSDVLL GPPPIIQSSL DGGKKYYVFF QYYYPPKVVT QQQVGGLLKG KAAAVEGSFF FFFFFFDVLL GPPPIIQSSL DGGKKYYAFF QYYYPPKVVT QQQVGGLLKG KAAAVEGTFF FFFFFFEVLL GPPPIIQSSL DGGKKYYAFF QYYYPPAVVA QQQAGGLLKG VYYYVEDEEE EYYYYYSVLL GPPPIIQSSL DGGKKYYVFF QYYYPPLKKN QQQIGGSSTE KVVVLGK--- -IIIIIEAII GPPPLLQSSL DGGKKYYVYY QYYYPPKKKN QQQIGGSSSE KVVVLEH--- -IIIIIPAII GPPPLLQSSL DGGKKYYVYY ---------- ---------- ---------- ---------- GPPPIIQSSV DGGKKYYVYY QYYYRRARRT QQQLGGAARD RVVVLDEKEE EPPPPPEPLL GPPPLLQSSL DGGRRYYVFF QYYYPPEKKT QQQLGGAASD VIIIVDEKEE EPPPPPPALL GPPPLLQSSL DGGKKYYVYY ---------- ---------- ---------- ---------- ---------- ---------- LFFFPPHFFI EEEIDRQQ-- ---------- ---------- ----VVSSSW DGGKKYYFLL LFFFPPHRRV EEEIGAQQ-- ---------- ---------- ----VVSSSW DGGQQYYYLL TTDQYYPEGW MMMVKLLNNA AAN----PPP PGGIIDED-- ---QLSGAAS SSSSYYP--- SSNQYYP-GW MMMAKVVNNV VVN----PPP PGGLLEED-- ---QLWGAAS SSSSYYP--- TTDQYYPDGA QQQVLAAHHA AAG----PPP PGGLLADE-- ---QLEGCCS SSSSYYPSSV TTDQYYPDGV EEEVMAANNV VVG----GGG GGGLLDDS-- ---QLEGCCS SSSSYYPSSV TTDQYYPGDA MMMVMAANNV VVG----EEE EGGLLDDD-- ---QLEGCCS SSSSYYPSSV AADQYYPEGW MMMVKLLDDA AAG----PPP PGGFFDKE-- ---QLQGCCS SSSSYYP--- AADQYYPDGW MMMVKVVDDV VVN----PPP PGGFFDND-- ---QLQGAAS SSSSFFP--- SSDQYYPVGW IIIAKAAEEA AAD----PPP PGGLLDGE-- ---QLEGSSS SSSSYYPSS- DDDQYY-PDE GGGSVMMLLQ QQVVVVTVVV VGGLLNNDLL LGPEYPGCCS SIII------ AADQYY-PNE GGGSVMMLLQ QQIVVVTAAA AGGLLNNDLL LGPEYPGCCS SIII------ AADQYY-PDE GGGSVMMLLQ QQIVVVTVVV VGGLLNNDLL LGPEYPGCCS SIII------ AADQYY-PDE GGGSVMMLLQ QQIVVVTVVV VGGLLNNDLL LGPEYPGCCS SIII------ AADQYY-PDE GGGSVMMLLQ QQVVVVTVVV VGGLLNNDLL LGPEYPGCCS SIII------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AADQYY-PDE GGGSVMMLLQ QQVVVVTVVV VGGLLNNDLL LGPEYPGCCS SIII------ DDDQYY-PDE GGGSVMMLLQ QQIVVVTVVV VGGLLNNDLL LGPEYPGCCT TIII------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKDQYY-PDE GGGSVMMLLQ QQIVVVTEEE EGGLLNNDGG GGPEYPGCCS SIII------ IIDQYY-PDE GGGAVMMLLQ QQIVVVTKKK KGGLLNNDDD DGPEYPGCCT TIII------ AADQYY-PGK GGGSHIILLQ QQIVVVTEEE EGGIINNDDD DGPEYPGCCT TIII------ AADQYY-PKQ GGGSHIILLQ QQIVVVTEEE EGGIINNDDD DGPEYPGCCT TIII------ AADQYY-PEK GGGSHIIIIQ QQIVVVTEEE EGGIINNDEE EGPEYPGCCT TIII------ AAVSYY-PEK GGGSHIIIIQ QQIGGGTEEE EGGIINDDDD DGPEYPGCCT TIII------ RRDQYYGQDK GGGSHMMLLQ QQIVVVTEEE EGGIINNDEE EGPEYPGCCT TIII------ KKDQYY-PES GGGATMMVVQ QQVIIIPEEE EGGIINDDGG GGPEYPGCCT TIII------ KKDQYY-PES GGGATMMLLQ QQIVVVPIII IGGIINNDGG GGPEYPGCCT TIII------ TTDQYY-PNE GGGSVMMLLQ QQIVVVTEEE EGGVVNNDNN NGPDFPCSST TIII------ PPDQYY-PEA GGGGTIIVVQ QQLIIIVEEE EGGLLNNDYY YGPE------ ---------- PPDQYY-PKQ GGGGHIIVVL LLIVVVTVVV VGGLLNDDYY YGPEYPGCCT TIIIAANDDA ---------- ---------- ---------- ---------- ---------- ---------- NND------K GGGKDDDAAQ QQYKKKYNNN NDDLLVDDLL LG-IFGSLLY Y--------- NND------K GGGKDDDEEQ QQFKKKYYYY YDDLLKQDLL LG-QFGALLY YPPPDDGNNR ------- ------- VVKKKK- VV----- VV----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AA----- ------- ------- RRLLLLV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNSAAKKKKQ QSSEATPCCT AAVTGGTTAA RRRLAAAAGM MMQLRTTAQQ LLLTGGSPVR gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IAYQEAAAAW SSSSSAAVSS SPEESTSVVG GLVEIAKQVV VPSAAVVVVQ QQAHPPGGHA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----AARREA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MGGEEPH ---------- ---------- ---------- ---------- ---------- --LKQQCCGD ---------- ---------- ---------- ---------- ---------- ---------- --MAGRSSSA LLLPPPPNPP TPNNPSPHHR RVPLTVYRTT INVPRLLLLP PPPPRRSSVQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----KKRRF- ---------- ---------- ---------- ---------- ---------- ----KKFFVG ---------- ---------- --MAVPPFFF KKYPPPKKKM AAMKAPPEYY VACYTTGIID ---------- ---------- ----AKKLLL KKYPPPRRRD AAMRAPPEYY VAAYVVGVVD ---------- ---------- ----MSSMMM RRHAAPEEEL AAMQAPAEYY TLLSPPS--D ---------- ---------- ----MTTMMM RRHAAPKKKL AAMEAPAEYY TLLSPPS--D ---------- ---------- ----MTTLLL RRYPPAKKKL AAMEGPVEFF TLMSPPS--D ---------- ---------- ----ATTWWW KKYPPPRRRL AAAKAPPEYY VAMDPPK--D ---------- ---------- ----VTTWWW RRYPPPRRRM AAVKAPAEYY VVRNPPNGGD ---------- ---------- ----ASSWWW RRYPPPKKKM AAMQAPREYY VALDPPE--D ---------- ---------- AATKTKK--- --PTTLEEEA MMK-GPREYY LPCYRRGTTD ---------- ---------- ---------- ---------- --M-GPREYY LPCYRRGIID VLLLPPAAAA ARLLPPP--A SSTQGKK--- --PSSLEEEA MMK-GPREYY LPCYGGGIID ---------- ---------- ---------- ---------- MMK-GPREYY LPCYRRGIID ---------- ---------- AATKGNN--- --STTLEEEA MMK-GPREYY LPCYRRGTTD TLLLVVAAAA AQMRPPPAAS AATKGNN--- --STTLEEEA MMK-GPREYY LPCYRRGTTD ---------- ---------- AATKGNN--- --STTLEEEA MMK-G----- -------TTD ---------- ---------- AATKGNN--- --STTLEEEA MMK-GPREYY LPCYRRGTTD AQQQFFLLLL LSQLWWWEED AATKGDD--- --PTTQEEEA MMK-GPREYY LPCYRRGTTD TNNNLLHHHH HTCTLLLFFT PPTKGNN--- --STTLEEEA MMK-GPREYY LPCYRRGTTD ---------- ---------- AATKGNN--- --STTLEEEA MMK-GPREYY LPCYRRGTTD IMMMAAAAAA AAETAAAAAA GGKTCHHTTT AAATTLEEEA MMEKGPREYY VTCYNNGIID ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMAKGSS--- --KSSLDDDA MMK-GPREYY LPCYRRGIID -MMMVVLLLL LDGVVVVEEK SS-VGCCCCC KKASSIEEES MMS-GPREYY VTAYAAGIID -MMMVVLLLL LQAVVVVEEK NNNQGCCCCC KKASSLEEEA MMS-GPREYY VTAYAAGIID ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MLLQQQ VVATTLAAAA MMS-GPSEYY VTAYTTGIID ---------- ---MAAAAAA GGAACGGGGG AAATTLEEEA MMEKGPREYY VTCYNNGIID ---------- ----MMMPPN GGLKHGG--- --ASSADDDA IIK-GPREFF VTA---AAAD ---------- ----MMM--- PPLKHGG--- --ASSADDDA IIK-GPREFF VTA---ARRD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MSSKKCCC KKATTLDDDA VVRNGPVEYY VVCQPPDEED ---------- ---------- ---------- ---------- MMRSGPREYY TVTQPPDEED ---------- ---------- ---------- --ITT-DDDI LLISLDDRFF SNWHGGRQQT ---------- --LAAAA--A AAMGPFFRRR AACQQPYYYM PPKITGQEYY VWTGVVMGGD SMMMAALLLL LRLVSSSLLA AALAPAAGGG VVCAAPYYYM KKKITGQEYY VWTGAAVGGD DFAVVDNKSS EYSVHKELNF WWNACCSS-- -PNNIERRRR FLLIIVPPGL LRSSSSYYDK DFAVVDDKSS PYGIYKDLGF WWNACCSS-- -PFFLERRRR YLLIIVPPAL LRSSSSYYDK DAAVIDKGSS SYGVHTTMGF WWNACCSS-G GAFFLERRRR FLLIIIPPGL LRSSSSYYDK DAAVIDKGSS PYGVHTTMGF WWNACCSS-G GAFFIERRRR YLLIIIPPGL LRSSSSYYDK DGAVVDDTSS EFGVHQIMGF WWNACCSS-G GAFFLERRRR YLLIIIPPGI IRSSSSYYDK DAAVVDDASS PYAVGQAMGF WWNACCSS-P PPHHMERRRR YLLVVVPPGL LRSSSSYYDK DACVVDDQSS SFGVGVDMGF WWNACCSS-P PPHHVERRRR YLLVVVPPDI IRSSSSTTDK DAGVLDDDSS GYAVGREMAF WWNACCSS-P PPHHVERRRR YLLIIVPPGI IRSSSSHHDK DYATVDDKSS PYSIHRPMKS WWNTCCSS-G GSTTKSRNNN KLLIILPPGL LMSSSSYYDG DYATVDDKSS PYSIHRPMKS WWNTCCSS-G GSTTKSRDDD KLLIILPPSI IISSSSYYDG DYATVDDKSS PYCIHRPMRS WWNACCSS-G GSTTKSRTTT KLLMMLPPCL LMSSSSYYDG DYATVDDKSS PYCIHRPMKS WWNTCCSS-G GITTKARTTT KLLVVLPPAL LISSSSYYDG DYATVDDKSS PYCIHRPMKS WWNTCCSS-G GSTTKSRTTT KLLVVLPPSL LISSSSYYDG DYATVDDKSS PYCIE----- ---------- ---------- ---------- ---------- DYATVDDKSS PYCIHRPMKS WWNTCCSS-G GSTTKSRTTT KLLVVLPPSL LISSSSYYDG DYATVDDKSS PYCIHRPMKS WWNTCCSS-G GSTTKSRTTT KLLVVLPPSL LISSSSYYDG DYATVDDKSS PYSIHRPMKS WWNTCCSS-G GSTTKSRNNN KLLVVLPPSF FISSSSYYDG DYATVDDKSS PYCIHRPMKS WWNTCCSS-G GSTTKSRTTT KLLVVLPPSL L--------- DYATVDDKSS PYCIHRPMKS WWNTCCSS-G GSTTKSRTTT KLLVVLPPSL LISSSSYYDG DYATVDDSSS PYSIHRPVGS WWNSCCSS-G GPSSAKRRRR FLLIILPPSL LLSSSSYYDA ---------- -------MNS WWNTCCSS-G GASSKVRNNN KLLIILPPCL LISSSSYYDG DYATVDDKSS PYSIHRPMNS WWNTCCSS-G GSSSKVRNNN KLLIILPPCL LISSSSYYDG DYATVDDSSS PYSIHRPVGT WWNSCCSS-G GPSSAERRRR FLLIIAPPSL LVSSSSYYDK DYATVDDNSS PYSIHRPVGT WWNSCCSS-G GPSSAQRRRR FLLIIVPPGI IVSSSSYYDK ---------- -------MGS WWNSCCSS-G GASSADRRRR YLLVVLPPSL LISSSSYYDK DYATVDDSSS PYSIHRPMGS WWNSCCSS-G GASSVDRRRR YLLVVLPPSL LISSSSYYDK DYGTVDDNSS PYSIHRPVGS WWNACCSS-G GPSSASRRRR FLLIILPPSL LLSSSSYYDL DAFTVDNESS DFCISRDVGT WWNACCSS-D DPTTEKRSSS HLLIIVPPCL LNSSSSYYNE DAFTVNNESS EFCISRDVGT WWNACCSS-D DPTTEKRSSS HLLIIVPPCL LNSSSSYYNE ---------- ---------- ---------- ---------- -MMVVPRRKL LSSSSSGGFG DYATVDDASS PYCIHRYTHS WWNTCCSSVG GEVVPTRDDD RLLVVLPPCL LNSSSSFFDG DYSTVDDESS PYCVHRFTGS WWNACCSSVS STVVPKRDDD RLLVVLPPSL LNSSSSYYDV TDKNPRVQVV FGGLKDPVES PPTPRRII-G GRVVQGGPPP QMMLLQLLSL LDGGGGYYTL DKVTIDRGSS ARGINSSVRG FFSA------ -----DRRRR FFFWWTGGGL LDTTTTFFDH DKVTVDNKSS PYGVNTSVRS FFTD------ -----DRRRR YLLWWAGGGL LDTTTTFFDH PREEPIVIEE EEKKSSSGGY YSSSSRLHHT VPDIIYIISS GE-GEGGGIL LLDYSEPPPI KRRRPAIVEE EVVGTTTGGY YTTTTKYHHT VPDIIYIISS GP-GEGGGIF FLDDTEPPPV PTQQAHIIED DELATTTGGY YSSSSRPHHT VPEIIYVVSS GAGGDPPGIF FMDETDVVVI PTKKAHIIEE EEFKTTTGGY YSSSSRPHHT IPDIIYVVSS GGGGNPPGVF FMDETEVVVI PLKKAHIIEE EEFATTTGGY YSSSSRPHHT IPEIIYVVSS GGGGDPPGIF FLDETEIIIM PLKKPAVIEE ETAETTTGGY YSSSSRPHHT VPGIIYVVTT GA-GKGGGIA ALDQSEPPPV PTQQPVVIDN NEAETTTGGY YAAAARPHHT VPDIIYIISS GP-GEGGGIF FLDDNEVVVI PREEPVVIEE EEHRTTTGGY YSSSSRPHHT IPDVVYVVSS GP-GDGGGVF FMDESDPPPV PRAAPHVIES SEQACCCNNV VSSSSNTHHT SASEEVMMVV LD-QNGGSFV VLDETEVVVK PRAAPHVIEN NEHACCCNNL LGGGGNLHHT SASEEVMMII LD-QNGGGFV VLDETEVVVK PRAAPHVIEE EDHACCCGGL LGGGGYVHHT SASEEVMMII LD-KNGGGFV VLDETEVVVQ PRAAPHVIEK KDHTCCCNNL LGGGGFFHHT SPSEEVMMVV LD-ENGGGFV VLDKTEVVVQ PRAAPHVIEE EDHACCCEEL LAAAAFLHHT SASEEVMMII LD-KNGGGFV VLDETEVVVR ---------K KDHACCCEEL LAAAAFLHHT SASEEVMMII LD-KNGGGFV VLDETEVVVR PRAAPHVIEK KDHACCCEEL LAAAAFLHHT SASEEVMMII LD-KNGGGFV VLDETEVVVR PRAAPHVIEK KDHACCCEEL LAAAAFLHHT SASEEVMMII LD-KNGGGFV VLDETEVVVR PRAAPHVIEK KDHECCCGGL LGGGGTPHHT SPTEEVMMII LD-KNGGGFV VLDETEVVVR ---------- ---------- ---------- ---------- ---------- ---------- PRAAPHVIEK KDHACCCEEL LAAAAFLHHT SASEEVMMII LD-KNDDGSL LLL-RECCC- PRTTPHVVEE EDAEIIIGGL LGGGGFPHHT SASDDIMMII LD-ENGGNGF FLLSENVVVN PRAAPHTVEY YEFWCCCGGL LAAAANLHHT SGCEEIMMII ID-YNGGGFV VLDETEVVVA PRAAPHTVEY YEFWCCCGGL LAAAANPHHT SGCEEIMMII LD-CNGGGFV VLDETEVVVV PRSSPHVVDA ADIQTTTGGL LAAAAYPHHT SASEELMMII LD-DNGGNGF FLLSDNVVVK PRAAPHVVEE EDSTTTTGGL LAAAAYPHHT SASEEIMMII ID-DNGGNGF FLLSENVVVK PRAAPYYVDK KEAETTTGGL LAAAAYPHHT AASEEILLVV LD-ENGGNGF FLLSDNIIIK PRAAPYYVDK KEADTTTGGL LAAAAFPHHT AT-EEILLVV LD-ENGGNGL LLLSDNIIIK PRAAPHVVEE EDAETTTGGL LGGGGFPHHT SASEEIMMII LD-ENGGNGF FLLSENVVVK -RKKIETIES SKHSNNN--L LSSSSFPHHT SADNNIMMII LE-NTGGNFL LLDKTEPPPA -REEIQTIES SKHANNN--L LSSSSFPHHT SADNNIMMII LE-DSGGNFL LLDKTEPPPA ---------- ---------- ---------- ---------- ---------- ---------- PRAAPAVIE- -DLKAAADDC CTTTTAPHHT TPNNNIMMII MD-ENGG-DF FEFKNELLLR PRKKPVTID- -DLKHHHNNV VTTTTAPHHT TANNNIMMII MD-EYGG-DF FLFSDNCCCK AWDDKY---- -DIKLLLVVL LAAAAISHHT APNAALKKQQ VE-LVLLNGI ITSHEGLLLA PSNNPHTID- -FKDGGGGGV VVVVVGPHHT FPGMMMIITT SD-DGTTALV VYNDGYVVVP PARRPSTIT- -FEKGGGGGV VVVVVGPHHT LPGMMLIITT SN-DGTTALV VYTAGYVVVP IDRRDDQQYY Y--------- ---LAYYWWW N-PVVSSSSS EEAAVVVVPP N--TEDLEHH VYRRPPQQYY Y--------- ---FAYYWWW N-PIISSSSS EETTVVVVPP R--CEEFECC IDRRPPQQDD D--------- ---KHYYWWW N-PVVSSSSS EEAALLLLPP P--QENIEDD IDRRPPQQTT T--------- ---LHYYWWW N-PVVSSSSS EEAALLLLPP P--QENIEDD MDRREEQQTT T--------- ---KHYYWWW N-PVVSSSSS EEGGLLLLPP P--QENIEDD VERRPPQQYY Y--------- ---FAYYWWW H-GVVSSSSS EEGGTTTTPP D--MEDLDII IDRRDDQQYY Y--------- ---LHYYWWW H-GLLSSSSS EEGGTTTTPP R--MESVDEE VERRPPQQQQ Q--------- ---LAYYWWW H-GVVSSSSS EEGGTTTTPP N--MEGLQII KPGGAASSPP P--------- ---MGYYWWY Q-RVVTTTTT EEAAAAAAPP N--VKDNHVV KPGGEEAAPP P--------- ---MGYYWWY Q-RVVTTTTT EEAAAAAAPP N--VKDNHVV QPGGAAAAPP P--------- ---MGYYWWY Q-RIITTTTT EEAAAAAAPP N--VRDNDVV QPGGAAAAPP P--------- ---LGYYWWY Q-RIITTTTT EEAAAAAAPP N--VRDNDVV RPGGAAAAPP P--------- ---SGYYWWY Q-RIITTTTT EEAAAAAAPP N--VRDNDVV RPGGAAAAPP P--------- ---LGYYWWY Q-RIITTTTT EEAAAAAAPP N--VRDNDVV RPGGAAAAPP P--------- ---LGYYWWY Q-RIITTTTT EEAAAAAAPP N--VRDNDVV RPGGAAAAPP P--------- ---LGYYWWY Q-RIITTTTT EEAAAAAAPP N--VRDNDVV RPGGSSAAPP P--------- ---MGYYWWY Q-RIITTTTT EEAAAAAAPP N--VQNNDVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----AAAAA IIAAHHHHSS N--LLTRPAA NRLLPPIISS S--------- ---KERRLLY EYAWWWWWWW IICCCCCCSS L--FTTECLL AEGGAAAAPP P--------- ---FGYYWWY Q-RIITTTTT EEGGAAAAPP K--AALKEVV VEGGSSAAQQ Q--------- ---FGYYWWY Q-RIITTTTT EEGGAAAAPP K--AALKDVV KPGGSSPPLL L--------- ---FGYYWWY Q-RIITTTTT SSGGAAAAPP T--ATKDHVV KPGGSSPPLL L--------- ---FGYYWWY Q-RIITTTTT SSGGAAAAPP K--ALQNHVV KPGGSSPPLL L--------- ---FGYYWWY Q-RIITTTTT SSGGAAAAPP K--ASKDHVV KPDDSSPPLL L--------- ---YGYYWWY Q-RIITTTTT SSGGAAAAPP K--ASKNHVV KPGGSSPPLL L--------- ---FGYYWWY Q-RIISSSSS SSGGAAAAPP A--ARTDHVV ADEETTVVPP P--------- ---FNYYWWY Q-RIITTTTT EEGGSSSSPP N--HKKNHVV ADGGVVVVPP P--------- ---FNYYWWY Q-RIITTTTT EEGGSSSSPP N--HKKNHVV ---------- ---------- ---------- -----IIIII LLGGGGGGPP V--TCRECQQ RGDDKKAALL L--------- ---CGYYWWY Q-HVVSSSSS EEGGAAAAPP K--LRRHDCC KGDDKKAALL L--------- ---CGYYWWY Q-YVVSSSSS EEGGAAAAPP N--KRRKDLL ASQQEEEEII I--------- ---LQLLHHN N--EEDDDDD RRDDEEEEPP I--MFEELKK PTAADDMMQQ QGAVVGDAAV ADDYGYYRRA L-RLLSSSSS SSTTGGGGWW SYYMDFMDAA PTDDDDLLRR RGAITG-KKY ADDYDYYRRA L-RVVSSSSS SSTTGGGGWW NYYMDFMDPP L-RRGGGGII HFWDDLLLRK RRISLTTEER RRRMML---- ----ELLLLL LLDKKKLGGG LGAAGGGGLL HVWDDLLLAK HHLAIDDQQR RRRMML---- ----EVVVLL LLDKKKLGGG LNKKGGGGLL HFWDDLLLRA NNVTIDDAAQ QQQMML---- ----EVVVAA AADRRREGGG LNKKGGGGLL HFWDDLLLRA NNVTIDDAAQ QQQMML---- ----EVVVAA AADRRREGGG LNKKGGGGII HFWKKLLLRD NNVTIDDAAQ QQQMML---- ----EIIIAA AADKKKDGGG LARRGGGGLL HFWDDLLLTR HHLEIDDDDQ QQQLLF---- ----ELLLAA AADKKKAGGG LGKKGGGGLL HVWDDLLLYR HHLTLDDAAQ QQQMML---- ----ELLLAA AADKKKAGGG LKGGGGGGLL HIWDDLLLRR HHLALDDEEQ QQQMML---- ----ELLLAA AADRRRTGGG EGLLGGGGII FVWDDWWWQR IIITLQQ--G GGGLLP---- ---LEIIILL LLDAAATGGG EGLLGGGGII HVWDDWWWQR IIITLQQ--G GGGLLP---- ---LEIIILL LLDAAATGGG EGLLGGGGLL HVWDDWWWQR IIITLTT--G GGGLLP---- ---LEIIILL LLNAAAAGGG KGLLGGGGLL YVWDDWWWQR IIVTLPP--G GGGLLP---- ---LEIIILL LLNAAAAGGG EGLLGGGGLL YVWDDWWWQH IIVTLSS--G GGGLLP---- ---LEIIILL LLNAAAAGGG EGLLGGGGLL YVWDDWWWQR IIVTLSS--G GGGLLP---- ---LEIIILL LLNAAAAGGG EGLLGGGGLL YVWDDWWWQR IIVTLSS--G GGGLLP---- ---LEIIILL LLNAAAAGGG EGLLGGGGLL YVWDDWWWQR IIVTLSS--G GGGLLP---- ---LEIIILL LLNAAAAGGG EGLLGGGGLL HVWDDWWWQR IIVTLLL--G GGGHHP---- ---LEIIILL LLDAAASGGG ---------- ---------- ---------- ---------- ---------- ---------- SSRRAAAATT ---------- ---------- ---------- ---------- ---------- TSGGHHHHSS CLDNNYYYIM IIDSLPP--Q QQQAAANNNP PPILCLLLII IIWIIINDDD QGMMGGGGLL NVWDDWWWTE RRITIDDEEG GGGLLP---- ---LEIIILL LLDAAAAGGG QGHHGGGGLL NVWDDWWWTE LLVTIDDKKG GGGLLP---- ---LEIIILL LLNAAADGGG AGLLGGGGLL TCIQQLLLAR LLRTLDDNNG GGGLLP---- ---LEIIILL LLDKKKDGGG AGLLGGGGLL HVYSSWWWPG IIKTLDDDDG GGGLLP---- ---LEIIILL LLDKKKDGGG AGLLGGGGLL HVYSSWWWPG MMKLIDDEEG GGGLLP---- ---LEIIILL LLDKKKDGGG AGLLGGGGLL HVYSSWWWPG IIKLIDDPPG GGGLLP---- ---LEIIILL LLDKKKDGGG QGLLGGGGLL HVYDDWWWPG LLKTLDDSSG GGGLLP---- ---LEVVVLL LLDKKKDGGG GGLLGGGGVV HIFEEWWWDS YYLTIDDQQG GGGAAP---- ---LEVVVLL LLESSSEAAA PGLLGGGGVV HIFEEWWWDT HHLTIDDMMG GGGAAP---- ---LEVVVLL LLESSSEAAA PPLLIIIIKK RVY------- ---------- ---------- ---------- ---------- DTQQGGGGLL NFYRRWWWQE LLFTIDDDDG GGGLLP---- ---LEIIILL LLNEEENGGG ESQQGGGGLL NFYKKWWWST LLYTIDDSSG GGGIIP---- ---LEIIILL LLNKKKAGGG KPLLPPPPVV AEVLL----- ---------- ---------- ---------- ---------- EKRRGGGGII VQWDDLLLHT PPKVFNNGG- ---------- ---LEIIIPP PPGAAANAAA EKHHGGGGVV VTWDDLLLHT PPKVFDDGG- ---------- ---LEIIIAA AAGHHHNCCC FNMVVVVSSD SSWWLWWWYD DGGKNAEEKK VIIPPAAELE EE---LLEEL LKPFKKAAPP FNVLLLLNND SSWWLWWWYD DGGKQAEERR VIIEEAAQFE EE---LLPPL LKDFKKMMPP FGVVVVVDDN EEWWTWWWRG GGGKHVKKKK TAAPPAAEAT TTDDDLLPPL LQGFGGAAPP FGVVVVVDDN EEWWTWWWRG GGGKHAEEKK TAAPPPPEAP PPEEELLPPL LQGFGGAAPP FGVVVVVDDN QQFFTWWWQD DGGTEAKKKK TIIDDPPVAD DDDDDLLDDL LKGFGGAAPP FNCIIIISSD SSWWTWWWRK KDDKAVRRKK VIIPPAAEAD DDDDDLLPPL LKGFKKAAPP FNCVVVVSSD SSWWLWWWRN NGGSHLKKKK VIIPPAAEAS SSDDDLLPPL LKPFKKAAPP FGVVVVVSSD SSWWLWWWRN NGGSGIRRKK VIIPPAAEAE EEDDDLLPPL LKDFGGAAPP FGCLLLLSSI RRNNEEEE-- ---------- -TTVVEEKIQ QQPPPKKVVG GWMLPPEEPP FGCLLLLSSI RRNNEGGG-- ---------- -TTVVEEKIQ QQPPPKKVVG GWMLPPEEPP FGCLLLLSSI RRNNQGGG-- ---------- -TTVVEEKIQ QQPPPKKVVG GWMLPPEEPP FGCLLLLSSI RRNNEDDD-- ---------- -TTAAQQKIQ QQPPPKKVVG GWMLPPEEPP FGCLLLLSSI RRNNEGGG-- ---------- -TTVVEEKIQ QQPPPKKVVG GWLLPPEEPP FGCLLLLSSI RRNNEGGG-- ---------- -TTVVEEKIQ QQPPPKKVVG GWLLPPEEPP FGCLLLLSSI RRNNEGGG-- ---------- -TTVVEEKIQ QQPPPKKVVG GWLLPPEEPP FGCLLLLSSI RRNNEGGG-- ---------- -TTVVEEKIQ QQPPPKKVVG GWLLPPEEPP FGCLLLLSSI RRNNEGGG-- ---------- -TTVVEEKIE EEPPPKKVVG GWMLPPEEPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YVVVVVVSSG GGPPDAAA-- ---------- -AALLKKRLD DDYYYAAVVK KFGVVVSSSS LGCLLLLSSV RREEKDDD-- ---------- -KKAAEEKIK KKPPPKKVVG GWALPPEEPP LGCLLLLSSI RREEKDDD-- ---------- -KKAAEEKIQ QQPPPKKVVG GWPMPPEEPP FGSLLLLSSM RRTTQDDD-- ---------- -SSHHEELIP PPKKKLLVVN NWILPPEEPP FGSLLLLTTM RRTTQDDD-- ---------- -SSHHEEIIS SSEEELLVVN NWFLPPEEPP YGSLLLLSSM RRNNSDDD-- ---------- -TTYYEEIIS SSKKKLLVVN NWILPPEEPP FGSLLLLSSM RRNNSDDD-- ---------- -TTHHEEVIS SSKKKLLVVN NWILPPEEPP YGCLLLLTTM RRTTADDD-- ---------- -SSHHEEVIS SSKKKLLVVN NWILPPEEPP FGCLLLLGGI RRVVEEEES- --------TT -TTAATTLAF FFPPPKKVVG GWALPPEEPP FGCLLLLGGI RRDDEKKKP- --------KK -VVAASSLAT TTPPPKKVVN NWALPPDDPP ---------- ---------- ---------- ---------- ---------- ---------- YGCFFFFXXX XX-------- ---------- ---------- -------GGN NGEIEEMMGG FGCLLLLNNV HHKKSDDDD- --------EE FEEKKVVIIP PPKKKVVTTS SGVAEEDDGG ---------- ---------- ---------- ---------- ---------- ---------- FTTLLLLTTL LLDDDAAA-- ---------- ---------E EEQQQKKVVD DIGNPPAAII FSTLLLLTTL LLDDGEEE-- ---------- ---------E EEQQQKKVVD DIGEPPAAVV PLVVVTTISL DDDFFLLLYY YLLLLWYDIN PPFFFKVLTT GKKKLGHRRH ---------- PLVVVTTISL DDDFFLLLYY YVLLLWYDIN PPHHHQRLAA GKKKIGHRRH ---------- PLVVVTTLSL DDDFFLLLYY YVCCCWYDVD PPHHHNVLAA GRRRIGRRRH ---------- PLVVVTTLSM DDDFFLLLYY YVCCCWYDVD PPRRRKKLAA GHHHIGRRRH ---------- PLVVVTTLSL DDDYYLLLYY YVCCCWYDVD PPMMMNVLTT GEEEIGKKKH ---------- PLVVVTTLSM DDDFFLLLYY YVCCCWYDVD PPFFFEKLTT GRRRIGSRRH G--------- PLVVVTTLSV DDDFFLLLYY YVCCCWYDVD PPFFFNRLTT GQQQIGRRRH ---------- PLVVVTTLSL DDDFFLLLYY YVCCCWYDVD PPFFFNRHTT GRRRLGRKKH ---------- GLIIITTLSL DDDFFLLLYY YFNNNWYDIN PPQQQKRLTT GFFFLGVRRS QVLLLE-DQQ GLIIITTLSL DDDFFLLLYY YFNNNWYDIN PPKKKKRLTT GFFFLGVKKS QVLLLE-DQQ GLIIITTLSL DDDFFLLLYY YFNNNWYDID PPQQQRRLTT GFFFLGVKKP QVLLLE-DQQ GLIIITTLSL DDDFFLLLYY YFNNNWYDVD PPQQQRRLTT GFFFLGVKKP QVLLLD-DQQ GLIIITTLSL DDDFFLLLYY YFNNNWYDID PPQQQRRLTT GFFFLGVKKP QVLLLE-DQQ GLIIITTLSL DDDFFLLLYY YFNNNWYDID PPQQQRRL-- ---------- ---------- GLIIITT--- ---------- ---------- ---------- ---------- ---------- GLIIITTLSL DDDFFLLLYY YFNNNWYDID PPQQQRRLTT GFFFLGVKKP QVLLLE-DEE GLIIITTLSL DDDFFLLLYY YFNNNWYDID PPKKKRRLVV GFFFLGVKKP QVLLLE-DQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NEFFFPPIFF SDDLLIIIII IFSSS----- ---------- ---------- ---------- GLIIITTISL DDDFFLLLYY YFNNNWYDID PPRRRNKLVV GFFFLGLRRP TVLLLE-DKK GLIIITTISL DDDFFLLLYY YFNNNWYDID TTRRRNKLVV GFFFLGQRRP TVLLLE-DKK GLIIITTISL DDDFFLLLYY YFNNNWYNID LLKKKNVLTT GWWWVGQKKP AAIIIG-EDD GLIIITTISL DDDFFLLLYY YFNNNWYNID VVKKKNKLTT GWWWAGQKKP VAVVVK-DDD GLIIITTISL DDDFFLLLYY YFNNNWYNID PPKKKNVLTT GWWWVGQKKP KAVVVG-EDD GLIIITTISL DDDFFIIIYY YFNNNWYNID PPKKKNVLTT GWWWVGQKKP KAVVVG-EDD GLIIITTISL DDDYYLLLYY YLNNNWYNID PPAAAKVLAA GWWWAGQKKE VYVVVT-EDD ALIIITTISM DDDFFLLLYY YVCCCWYDID PPLLLKKLNN SYYYIGHTTN KVLLLE-GEE ALIIITTISM DDDFFLLLYY YVCCCWYDID PPKKKNKLNN SFFFIGHSST KVLLLE-EDD ---------- ---------- ---------- ---------- ---------- ---------- GMMMMTTISL DDDYYLLLYY YFNNNWYDID RRAAANRLTT GFFFLGQRRP RVLLLN-DPP GMIIISSISL DDDFFLLLYY YVCCCWYDID PPEEENKLTT GFFFLGCSSP VIVVVKEDKK ---------- ---------- ---------- ---------- ---------- ---------- PLPPPVVIAA DDDTTLLLWW WISSSFFDID PPHHHKFQII YVVVIRN--- ---------- PLPPPVVISN DDDRRLLLWW WVTTTFFDID PPHHHHRQVV YTTTIAN--- ---------- ---------- ------AAAA HKKKKKGGAP PQQMSDDGRV VTNSYYSSST TTTWQYYGLL ---------- ------SSSS AEEEEEGGAP PQQMSDDGRV ITNSYYSSSS SSSWQYYGLL ---------- ------NNNN RTTTTTGGGP PQQMSDDGRV WTNSYYSSST TTTWQYYGVV ---------- ------NNNN KAAAAAAAGP PQQMSDDGRV WTNSYYSSST TTTWQYYGVV ---------- ------NNNN KTTTTTYYGP PQQMSDDGKV WTNSYYSSST TTTWQYYDRR ---------- -----AKKKK GAAAAAGGGP PQQMSDDGRV FTNSYYGGGA AAAVQYYGII ---------- -----ATTTT AEEEEEGGGP PQQMSDDGRV FTNSYYRRRA AAAWQYYGII ---------- ------AAAA GPPPPPGGGP PQQMSDDGRV FSNSYYAAAS SSSWQYYGII QEELTCCQQE PLVVVVKKKK KRRRRRGGGP PQQMSDDGKL ATTSYYSSSD DDDWQYYDLL QEELTCCQQE PLVVVVKKKK KRRRRRGGGP PQQMSDDGKL VTTSYYSSSA AAAWQYYNLL QEELKSSQQE PLVVVVKKKK KKKKKKGGGP PQQMSDDGKL VTTSYYSSSA AAAWQYYDLL QEELDSSQQE PLVVVVKKKK KQQQQQGGGP PQQMSDDGKL VTTSYYSSSA AAAWQYYDLL QEELKSSQQE PLVVVVKKKK KRRRRRGGGP PQQMSDDGKL ITTSYYSSSA AAAWQYYDLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EEELKSSQQE PLVVVVKKKK KRRRRRGGGP PQQMSDDGKL ITTSYYSSSA AAAWQYYDLL QEELKSSQQE PLVVVVKKKK KRRRRRGGGP PQQMSDDGKI VTTSYYSSSD DDDWQYYDLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KDDLECCQQD PVIIIVKKKK KKKKKKGGGP PQQMSDDGKL VTNSYYSSSK KKKWQYYDMM KEELECCQQD PVTTTVKKKK KIIIIIGGGP PQQMSDDGKI VTSSYYSSSI IIIWQYYDLL DGGKTWWQQD VPEEEIQQQQ QKKKKKGGGP PQQMTDDGKL VTNSFFSSSA AAAWQYYGLL DGGETWWQQD VPEEEIQQQQ KKKKKKGGGP PQQMSDDGKL VTNSFFSSSA AAAWQYYKLL DGGNSFFQQD VPQQQIKKKK KSSSSSGGGP PQQMSDDGKL ATNSFFSSSA AAAWQYYELL DGGNTFFQQE VPQQQIKKKK KSSSSSGGGP PQQMSDDGKL ATNSFFSSSA AAAWSYYEII DDDKEEEQQS VPQQQVKKKK HRRRRRGGGP PQQMSDDGKI VTNSFFSSSR RRRWQYYDLL EKK----PPE ALYYYVKKKK RKKKKKGGGP PQQMSDDGKL VTTSYYKKKK KKKWQYYEHH DHHD---EEP ALYYYVKKKK RQQQQQGGGP PQQMSDDGKL VSTSYYKKKK KKKWQYYENN ---------- ---------- ------GGGP PAAKSDDGKL VTNSYYSSST TTTWQYYNVV PEELKEEAAE PVFFFLKKKK RRRRRRGGGP PQQMSDDGRL VSSSFFSSSP PPPWQYYEMM KEELKEERRP ARYYYVKKKK RRRRRRGGGP PQQMSDDGKL VSSSYYSSSP PPPWQYYKMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MSDDGKV FSSSLLAAAN NNNW------ ---------- ---------- ---------- ---MSDDGQL YTSSLLAAAN NNNW------ LMKKLLAAN- ---SLLLEEE IIEFVGGEE- -----RSHQR RSSGGAASSS SYYYYPP--- LMKKVVVVN- ---ELLLEEE LLEFVGGRR- -----RAHQR RWWGGAASST SFFFYPP--- VQLLAAAAG- ---DLLLTTT LLDWVPPDDG G----RAHQR REEGGCCSST SFFFYPPSSV VEMMAAVVG- ---NLLLEEE LLDFVPPDDG G----RAHQR REEGGCCSST SFFFYPPSSV RMMMAAVVG- ---NLLLTTT LLDWVPPAAG G----RSHQR REEGGCCSST SFFFYPPSSV IMKKLLAAG- ---NIIIEEE FFKFLPPKKG G----RPHQR RQQGGCCSSS SYYYYPP--- IMKKVVVVN- ---DMMMQQQ FFNFVGGEE- -----RVHQR RQQGGAASSS SYYYFPP--- IIKKAAAAD- ---GLLLSSS LLGFTGGDDG G----RPHQR REEGGSSSSS SYYYYPPSS- LGVVMMQQVD VVDNLLLKKK LLNLVGGKKE ELLLGLAHER RPPGGCCSSS IWWW------ LGVVMMQQID VVDNLLLKKK LLNLVGGKKE ELLLGLAHER RPPGGCCSSS IWWW------ LGVVMMQQID VVDKLLLKKK LLNLVGGKKE ELLLGLAHER RPPGGCCSSS IWWW------ LGVVMMQQID VVDKLLLTTT LLNLVGGKKE ELLLGLAHER RPPGGCCSSS IWWW------ LGVVMMQQVD VVDKLLLKKK LLNLVGGKKE ELLLGLAHER RPPGGCCSSS IWWW------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGVVMMQQVD VVDKLLLKKK LLNLVGGKKE ELLLGLAHER RPPGGCCSSS IWWW------ LGVVMMQQID VVDKLLLKKK LLNLVGGKKE ELLLGLAHER RPPGGCCTTS IWWW------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MGVVMMQQID VVDKLLLKKK LLNLVGGKKE EGGGGLAHER RPPGGCCSSS IWWW------ LGVVMMQQID VVDKLLLKKK LLNLVGGKKE EDDDGLAHER RPPGGCCTTS IWWW------ LGHHIIQQID VVDKLLLKKK IINFVGGAAE EDDDGLAHER RPPGGCCTTS IWWW------ LGHHIIQQID VVDNLLLKKK IINFVGGAAE EDDDGLAHER RPPGGCCTTS IWWW------ LGHHIIQQID VVDKLLLSSS IINFVGGDDE EEEEGLAHER RPPGGCCTTS IWWW------ IGHHIIQQID GGDKLLLTTT IIDFVGGDDE EDDDGLAHER RPPGGCCTTS IWWW------ LGHHMMQQID VVDKLLLSSS IINFVGGAAE EEEEGLAHER RPPGGCCTTS IWWW------ HGTTMMQQVN IIDSMMMEEE IIDLIGGKKI IGGGGLAHER RPPGGCCTTS IWWW------ NGTTMMQQID VVDTMMMVVV IINLIGGKKV VGGGGLAHER RPPGGCCTTS IWWW------ VGVVMMQQID VVDKLLLTTT VVNLVGGKKE ENNNGLAHDR RPPCGSSTTS ILLL------ MGTTIIQQLD IIDNMMMKKK LLNLVGGGGE EYYYGLPHER R--------- ---------- MGHHIILLID VVDNIIISSS LLDLVAANNE EYYYGLPHER RPPGGCCTTS IWWWANNDDA ---------- ---------- ---------- ---------- ---------- ---------- -GDDDDQQYL KKAWKKKEEE LLDAVYYEEL LLLLGRAHIR RGGSSLLYYS ---------- -GDDDDQQFL KKLWKKKEEE LLQAIYYAAE ELLLGRPHQR RGGARLLYYA PAAADGGNNR ------- ------- KR----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LVQARVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158AKKKSSATTP PTTAVTGGLL TAAAALADMS LRRTTTQQLL LPPPGVIKAA AYQEEAAWWT gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -MAGGSSAAP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TIQQVVLLSP SSSESKKKGG GGRRRSSPLI ISSSAAVVVQ VVPPSAAAAA AQQAAAWLLP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------GLLG ---------- ---------- ---------- ---------- ---------- ---LLLNSSQ ---------- ---------- ---------- ---------- ---------- ---------- PLNNNNRRTP PPPNPLLLAA AAPPPPPPVT TRRRVVRRRR TINNVPPRRR RPPPPPHAAR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMK ---------- ---------- ---------- ---------- ---------- -------MMK ---------- ----IVFRPF FYYPPPPKAM KKPPPEEDDD LAYYYVAACL GTTINDIVDV ---------- ----MALPPF FYYPPPPRAM RRPPPEEDDD IAYYYVAAAL GTTVNDLVDV ---------- -----MMPPF FHHAAAPEAM QQAAAEEEEE FAYYYTLLLL DFF--DLVDV ---------- -----MMPPF FHHAAAPKAM EEAAAEENNN FAYYYTLLLL DFF--DLVDV ---------- -----MLPPF FYYPPPAKAM EEVVVEEKKK LAFFFTLLML DAA--DLVDV ---------- ----MAWPPF FYYPPPPRAA KKPPPEETTT IAYYYVAAMF ERR--DIVDV ---------- ----MVWPPF FYYPPPPRAV KKAAAEEKKK LAYYYVVVRL MAAG-DMVDV ---------- ----MAWPPF FYYPPPPKAM QQRRREERRR LGYYYVAALL GRR--DLVDL ---------- ---MCT-CPY YPPTTTLEMK --RRREEEEE IVYYYLPPCI NTTTEDLTDV ---------- ---------- ---------M --RRREEEEE IVYYYLPPCI NTTIEDLTDV PPKHGAALLI LG-HCG-CPY YPPSSSLEMK --RRREEEEE IVYYYLPPCI NTTIEDLTDI ---------- ---------- --------MK --RRREEEEE IIYYYLPPCI NTTIEDLTDV ---------- ---MCG-CPY YSSTTTLEMK --RRREEEEE IVYYYLPPCI NTTTEDLTDV EEAEGAFLLQ MIATCG-CPY YSSTTTLEMK --RRREEEEE IVYYYLPPCI NTTTEDLTDV ---------- ---MCG-CPY YSSTTTLEMK ---------- ---------- ---TEDLTDV ---------- ---MCG-CPY YSSTTTLEMK --RRREEEEE IVYYYLPPCI NTTTEDLTDV KKEPGHTQQP QQETCG-CPY YPPTTTQEMK --RRREEEEE IVYYYLPPCI NTTTEDLTDV GGLGFDQNNT CVFSCG-CPY YSSTTTLEMK --RRREEEEE IVYYYLPPCI NTTTEDLTDV ---------- ---MCG-CPY YSSTTTLEMK --RRREEEEE IVYYYLPPCI NTTTEDLTDV HHLVLQHMME EAANCCTKPY YAATTTLEME KKRRREEKKK LVYYYVTTCV GTTINDLTDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----CG-CPY YKKSSSLDMK --RRREEEEE IVYYYLPPCI STTINDLTDV -------MMA GNEKNGCSPY YAASSSIEMS --RRREESSS LIYYYVTTAV GTTIEDLTDV -------MMG ASEVQGCSPY YAASSSLEMS --RRREETTT LIYYYVTTAV GTTIEDLTDL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RMQGPY YAATTTLAMS --SSSEEKKK LIYYYVTTAV GTTIDDLTDV ---------- -AANCCGTPY YAATTTLEME KKRRREEKKK LLYYYVTTCV GTTINDLTDV ---------- -SPCCH--PY YAASSSADIK --RRREEEEE VLFFFVTTAP -NNADDITDV ---------- -P-CCH--PY YAASSSADIK --RRREEEEE VLFFFVTTAP -HHRDDITNV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----ESCCPY YAATTTLDVR NNVVVEEKKK LLYYYVVVCV NLLEEDLTDV ---------- ---------- --------MR SSRRREEKKK LLYYYTVVTV NLLEPDLTDV ---------- --------PL LIITTT-DLI SSDDDRRFFF LYFFFSNNWL DIIQYTRNRM RREFG----- LG-LLPRFDT TCCQQQPYPK IIQQQEEEEE FVYYYVWWTL EGGGDDLTDL RRIVSGPMMH LGLLAPGRDT TCCAAAPYKK IIQQQEEDDD YVYYYVWWTL EGGGDDLTDA NPKKEETSKI IHKKVELYYI NNDELHHFGW WWWWASLLC- -NN-KKKKEE ERIVPGLRSS DPKKPPTGKV VYKKLDLYYI GGDELHHFGW WWWWASYYC- -NN-KKKKEE ERIVPALRSS KPGGSSTGKI IHTTVTMNNT GGDEFHHFGW WWWWASLLS- -LLGHHHHEE ERIIPGLRSS KPGGPPTGQI IHTTVTMNNK GGDEFHHFGW WWWWASLLS- -LLGHHHHEE ERIIPGLRSS DPTTEEKGQI IHQQLIMNNK GGDEFHHFGW WWWWASLLS- -LLGHHHHEE ERIIPGIRSS DPAAPPRASI IGQQVAMHHA GGDELHHFGW WWWWASLLC- -NNPHHHHEE ERVVPGLRSS DSQQSSTGQV VGVVTDMYYT GGGELHHFGW WWWWASLLC- -NNPHHHHEE ERVVPDIRSS DPDDGGTAQI IGRRVEMNNA AADELHHFGW WWWWASLLC- -YYPHHHHEE ERIVPGIRSS DPKKPPQSQV VHRRLPMYYL KKDELHHSGW WWWWTS---- ---GDDDDSS SRILPGLMSS DPKKPPHSQV VHRRLPMHHL KKDELHHSGW WWWWTS---- ---GDDDDSS SRILPSIISS DPKKPPQCQV VHRRLPMNNL RRDELHHSGW WWWWAS---- ---GDDDDSS SRMLPCLMSS DPKKPPQCQV VHRRLPMHHL KKDELHHSGW WWWWTS---- ---GDDDDAA ARVLPALISS DPKKPPQCQV VHRRLPMNNL KKDELHHSGW WWWWTS---- ---GDDDDSS SRVLPSLISS DPKKPPQCQV VE-------- ---------- ---------- ---------- ---------- DPKKPPQCQV VHRRLPMNNL KKDELHHSGW WWWWTS---- ---GDDDDSS SRVLPSLISS DPKKPPQCQV VHRRLPMNNL KKDELHHSGW WWWWTS---- ---GDDDDSS SRVLPSLISS DPKKPPQSQV VHRRLPMYYL KKDELHHSGW WWWWTS---- ---GDDDDSS SRVLPSFISS DPKKPPQCQV VHRRLPMNNL KKDELHHSGW WWWWTS---- ---GDDDDSS SRVLPSL--- DPKKPPQCQV VHRRLPMNNL KKDELHHSGW WWWWTS---- ---GDDDDSS SRVLPSLISS DPSSPPTSQV VHRRLPVHHI GGDKLHHSGW WWWWSS---- ---GDDDDKK KRILPSLLSG ---------- ------MNNT NNDELHHSGW WWWWTS---- ---GDDDDVV VRILPCLISS DPKKPPSSQV VHRRLPMNNV NNDELHHSGW WWWWTS---- ---GDDDDVV VRILPCLISS DPSSPPTSKV VHRRLPVYYV GGDELHHTGW WWWWSS---- ---GDDDDEE ERIAPSLVSG DPNNPPTSKV VHRRLPVYYV GGDELHHTGW WWWWSS---- ---GDDDDQQ QRIVPGIVSG ---------- ------MFFV GGDELHHSGW WWWWSS---- ---GDDDDDD DRVLPSLISG DPSSPPSSSV VHRRLPMFFV GGDELHHSGW WWWWSS---- ---GDDDDDD DRVLPSLISG DPNNPPTSQV VHRRLPVHHV GGDELHHSGW WWWWAS---- ---GDDDDSS SRILPSLLSG NPEEDDTCQV VSRRVDVHHI GGDEVHHTGW WWWWAS---- ---DKKKKKK KRIVPCLNSD NPEEEETCQI ISRRVDVNNI GGDEVHHTGW WWWWAS---- ---DKKKKKK KRIVPCLNSD ---------- ---------- ---------- ---------- ---------- --VPRKLSSG DPAAPPTCQV VHRRTYTSSK HHNELHHSGW WWWWTSHHFV V--GKKKKTT TRVLPCLNSD DPEEPPTCQI IHRRTFTRRK GGDELHHSGW WWWWASYYYV VEESKKKKKK KRVLPSLNSD VGQQFFLGSV VKDDGPVVVL EEDKEDDSQP PPPPPI---- ---GKKKKGG GGLQLSLDGK RPGGAATGQV VNSSVSVGG- RRNEAHHGGF FFFFA----- --------DD DRWTGGLDTN NPKKPPQGKV VNTTLSVGG- RRNEAHHSDF FFFFD----- --------DD DRWAGGLDTS SSSRRYYIID DTTKKKNREP IIKKKKVVII EPEVKKYYSR RLHTHHHCPP AYYYISSLLN SSSRRYYVVD DTTKKKDRRP VAKKKKIIVV EPEAVGYYTK KYHTHHHCPP AYYYISSLLG SSSRRYYIID DTTKKKHTQA IHKKKKIIII EPDILAYYSR RPHTHHHCPP GYYYVSSLLG SSSRRYYIID DTTKKKDTKA IHKKKKIIII EPEVFKYYSR RPHTHHHCPP GYYYVSSLLG SSSRRYYVVD DVVKKKELKA IHKKKKIIII EPEVFAYYSR RPHTHHHCPP GYYYVSSLLG SSSRRYYLLD DTTKKKDLKP LAKKKKVVII EPELAEYYSR RPHTHHHCPP GYYYVTTLLN SSSHHTTLLD DTTKKKDTQP VVKKKKVVII DPNLAEYYAR RPHTHHHCPP GYYYISSLLS SSSRRHHVVD DTTKKKDREP IVKKKKVVII EPELHRYYSR RPHTHHHCPP GYYYVSSLLS SSSRRYYVVD DVVGGGERAP LHKKKKVVII EASIQAVVSN NTHTHHHCAA GVVVMVVTTG SSSRRYYVVD DVVGGGERAP LHKKKKVVII EPNIHALLGN NLHTHHHCAA GVVVMIISSG SSSRRYYVVD DVVGGGDRAP LHKKKKVVII EAEIHALLGY YVHTHHHCAA GVVVMIITTG SSSRRYYVVD DVVGGGERAP LHKKKKVVII EPKIHTLLGF FFHTHHHCPP GVVVMVVTTG SSSRRYYVVD DVVGGGERAP LHKKKKVVII EPEIHALLAF FLHTHHHCAA GVVVMIISSG ---------- ---------- ---------- -PKIHALLAF FLHTHHHCAA GVVVMIISSG SSSRRYYVVD DVVGGGERAP LHKKKKVVII EPKIHALLAF FLHTHHHCAA GVVVMIISSG SSSRRYYVVD DVVGGGERAP LHKKKKVVII EPKIHALLAF FLHTHHHCAA GVVVMIISSG SSSRRYYVVD DVVGGGERAP LHKKKKVVII EAKIHELLGT TPHTHHHCPP GVVVMIITTG ---------- ---------- ---------- ---------- ---------- ---------- SSSRRYYVVD DVVGGGERAP LHKKKKVVII EPKIHALLAF FLHTHHHCAA GVVVMIISSG GGGRRYYVVD DTTAAADRTP LHKKKKVVVV ESEIAELLGF FPHTHHHCAA GIIIMIICCG SSSRRYYVVD DVVGGGDRAP IHKKKKTTVV EPYVFWLLAN NLHTHHHCGG GIIIMIISSG SSSRRYYVVD DVVGGGDRAP IHKKKKTTVV EPYVFWLLAN NPHTHHHCGG GIIIMIISSG GGGRRYYIID DTTKKKNRSP LHKKKKVVVV DPAIIQLLAY YPHTHHHCAA GLLLMIICCG GGGRRYYIID DTTKKKNRAP LHKKKKVVVV EPEISTLLAY YPHTHHHCAA GIIIMIICCG GGGRRYYIID DTTKKKNRAP LYKKKKYYVV DPKIAELLAY YPHTHHHCAA GIIILVVCCG GGGRRYYIID DTTKKKNRAP LYKKKKYYVV DPKIADLLAF FPHTHHHCTT GIIILVVCCG GGGRRYYVVD DTTLLLDRAP LHKKKKVVVV EAEIAELLGF FPHTHHHCAA GIIIMIICCG DDDRRYYIIN NVVEEEERKI LEHHHHTTII EPSLHSLLSF FPHTHHHCAA GIIIMIITTG DDDRRYYIIN NVVEEEEREI LQHHHHTTII EPSLHALLSF FPHTHHHCAA GIIIMIITTG GGGVVGGVVF FVVGGG---- ---------- ---------- ---------- ---------- DDDRRFFIID DTTGGGDRAP LAKKKKVVII EG-VLKCCTA APHTHHHCPP GIIIMIIIIG DDDFFYYLLD DVVVVVDRKP IVKKKKTTII DG-VLKVVTA APHTHHHCAA GIIIMIIVVG KKKRRYYTTT TSSLLLSWDK FYPPPP---- ---LIKLLAI ISHTDDDYPP TLLLKQQGGN NNNRRFFFFD DVVHHHDSNP LHKKKKTTII DT-VKDVVVG GPHTFFFAPP SMMMITTLLN SSSKKFFFFD DVVHHHDARP LSKKKKTTII TD-VEKVVVG GPHTYYYAPP RLLLITTLLN E------EGG -EGPPGGILL LSFFEEEEEE EDRRGDQQY- ---------- -LLYYFFFFF P------DGG REGPPGGIFL LTFFEEEEEE EYRRGPQQY- ---------- -FFYYFFFFF AGGGKKKDGG TDGAAPGIFM MTFFDDDDEE EDRRGPQQD- ---------- -KKYYFFFFF GGGGKKKDGG TNGPPPGVFM MTFFEEEEEE EDRRGPQQT- ---------- -LLYYFFFFF GGGGEEEDGG TDGPPPGIFL LTFFEEEEEE EDRRGEQQT- ---------- -KKYYFFFFF A------EGG -KGPPGGIAL LSFFEEEEEE EERRGPQQY- ---------- -FFYYGGGGG P------EGG -EGPPGGIFL LNLLEEEEEE EDRRGDQQY- ---------- -LLYYFFFFF P------EGG -DGPPGGVFM MSFFDDDDEE EERRGPQQQ- ---------- -LLYYFFFFF D------LQQ GNGKKGSFVL LTFFEEEEEE EPGGGASSP- ---------- -MMYYFFFFF D------PQQ GNGKKGGFVL LTFFEEEEEE EPGGGEAAP- ---------- -MMYYFFFFF D------SKK GNGKKGGFVL LTFFEEEEEE EPGGGAAAP- ---------- -MMYYFFFFF D------PEE GNGKKGGFVL LTFFEEEEEE EPGGGAAAP- ---------- -LLYYFFFFF D------VKK GNGKKGGFVL LTFFEEEEEE EPGGGAAAP- ---------- -SSYYFFFFF D------VKK GNGKKGGFVL LTFFEEEEEE EPGGGAAAP- ---------- -LLYYFFFFF D------VKK GNGKKGGFVL LTFFEEEEEE EPGGGAAAP- ---------- -LLYYFFFFF D------VKK GNGKKGGFVL LTFFEEEEEE EPGGGAAAP- ---------- -LLYYFFFFF D------PKK GNGKKGGFVL LTFFEEEEEE EPGGGSAAP- ---------- -MMYYFFFFF ---------- ---------- ---------- ---------- ---------- ---------- D------VKK GNGKKDGSLL LRLLEEEE-- ---------- ---------- ---------- D------KEE GNAAAGNGFL LEFFNNNNSS SRLLFPIIS- ---------- -KKRRHHHHH D------PYY GNGKKGGFVL LTFFEEEEEE EEGGEAAAP- ---------- -FFYYFFFFF D------PCC GNGKKGGFVL LTFFEEEEEE EEGGESAAQ- ---------- -FFYYFFFFF D------KDD GNAEEGNGFL LDFFNNNNEE EPGGHSPPL- ---------- -FFYYFFFFF D------KDD GNAEEGNGFL LEFFNNNNEE EPGGHSPPL- ---------- -FFYYFFFFF D------EEE GNAKKGNGFL LDFFNNNNEE EPGGHSPPL- ---------- -FFYYFFFFF D------EEE GNAKKGNGLL LDFFNNNNEE EPDDISPPL- ---------- -YYYYFFFFF D------KEE GNAAAGNGFL LEFFNNNNEE EPGGHSPPL- ---------- -FFYYYYYYY E------ANN GTPSSGNFLL LTFFEEEEPP PDEEKTVVP- ---------- -FFYYFFFFF E------ADD GSPSSGNFLL LTFFEEEEPP PDGGKVVVP- ---------- -FFYYFFFFF ---------- ---------- ---------- ---------- ---------- ---------- D------AEE GNAKKG-DFE ENFFEEEESS SGDDRKAAL- ---------- -CCYYYYYYY D------AEE GYAKKG-DFL LDFFNNNNTT TGDDKKAAL- ---------- -CCYYFFFFF E------SLL SVPVVLNGIT TENNGGGGEE ESQQFEEEI- ---------- -LLLLNNNNN D------DDD HGGRRTALVY YGEEYYYYMM MTAADDMMQG AVVGAVVADD GYYYYIIIII N------KDD HGGRRTALVY YGEEYYYYII ITDDGDLLRG AITGKYYADD GYYYYVVVVV WNLPELLLLL VSEEWAAAVV EEEDDG-KKE HLLD-RYYGG RRIHHFWWRK KRKSSLEMAL WNLPGMMMMM ISEEWTTTVV EEEEEG-SSE CLLEGAYYGG KKLHHVWWAK KRRAALEMVL WNLPDMMMMM VSEEWAAALL EEENNG-VVE DLLANKYYGG RRLHHFWWRA ARRTTLQMAL WNLPDMMMMM VSEEWAAALL EEENNG-VVE DLLSNKYYGG RRLHHFWWRA ARRTTLNMAL WNLPDMMMMM VSEEWGGGLL EEENNG-VVE DLLSNKYYGG KKIHHFWWRD DRKTTLNMAL WHLGDLLLLL VSEEWGGGTT EEEDDG-VVD ILLGARYYGG RRLHHFWWTR RRREEFELVF WHLGDLLLLL LSEEWGGGTT EEESSG-LLD ELLAGKYYGG RRLHHVWWYR RRRTTLEMAL WHLGDMMMMM VSEEWGGGTT EEEGGG-DDQ ILLNKGYYGG RRLHHIWWRR RRRAAVEMVL YQPRNMMMMM VTEEWAAAAA KKKDDGFPPH VEE-GLYYGG RRIFFVWWQR RHETTM-LIP YQPRNMMMMM VTEEWAAAAA KKKDDGFPPH VEE-GLYYGG HHIHHVWWQR RHETTM-LIP YQPRNMMMMM ITEEWAAAAA RRRDDGFPPD VEE-GLYYGG HHLHHVWWQR RHETTL-LIP YQPRNMMMMM ITEEWAAAAA RRRDDGFPPD VKK-GLYYGG HHLYYVWWQR RRETTL-LIP YQPRNMMMMM ITEEWAAAAA RRRDDGFPPD VEE-GLYYGG HHLYYVWWQH HHETTL-LIP YQPRNMMMMM ITEEWAAAAA RRRDDGFPPD VEE-GLYYGG HHLYYVWWQR RHETTL-LIP YQPRNMMMMM ITEEWAAAAA RRRDDGFPPD VEE-GLYYGG HHLYYVWWQR RHETTL-LIP YQPRNMMMMM ITEEWAAAAA RRRDDGFPPD VEE-GLYYGG HHLYYVWWQR RHETTL-LIP YQPRNMMMMM ITEEWAAAAA QQQNNGFPPD VEE-GLYYGG HHLHHVWWQR RHETTM-HIP ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AIISAAAHH LLLTTGSDDP ASS-SRVVAA IIT------- ---------- YENAGFFFFF WWIIQCCCCC TTTTTGALLC LTT-SGVVHH IISCCLDDIM MRVSSL-AGA YQPRNMMMMM ITEEWGGGAA AAALLGFMME VQQ-GMYYGG SSLNNVWWTE EHRTTL-LIP YQPRNMMMMM ITEEWGGGAA AAALLGFMMD VQQ-GHYYGG SSLNNVWWTE EHRTTL-LIP YQPRNMMMMM ITSSWGGGAA TTTKKGFLLH VAA-GLYYGG HHLTTCIIAR RGETTL-LLP YQPRNMMMMM ITSSWGGGAA LLLQQGFLLH VAA-GLYYGG HHLHHVYYPG GGETTL-LLP YQPRKMMMMM ITSSWGGGAA SSSKKGFLLH VAA-GLYYGG HHLHHVYYPG GGELLL-LLP YQPRKMMMMM ITSSWGGGAA SSSKKGFLLH VAA-GLYYGG HHLHHVYYPG GGELLL-LLP YQPRKMMMMM ISSSWGGGAA RRRTTGFLLH VQQ-GLYYGG HHLHHVYYPG GGETTL-LLP YQPRNMMMMM ITEEWGGGSS KKKKKGFPPH VGG-GLYYGG SSVHHIFFDS SKKTTLPALP YQPRNMMMMM ITEEWGGGSS KKKKKGFPPH VPP-GLYYGG SSVHHIFFDT TKKTTLPALP ---------- -ILLRGGGGG CCCRRDELLC QPP-PLVVII CCKRRVYY-- ---------- YQPHNMMMMM VSEEWGGGAA RRRRRGYPPD CDDRTQYYGG RRLNNFYYQE ERETTL-LTP YQPYDMMMMM VSEEWGGGAA RRRRRGWNND LEEMSQYYGG RRLNNFYYST TQTTTL-ITP NNG-ESSSSS EDRRPDDDEE FFFEESSSSL KKKGPLKKPP HHVAAEVV-- ---------- ALIRNMMMMM LSSSFTTTGG DDDFFGQLLD AEEMKRFFGG TTIVVQWWHT TRQVVVA--- ALPRNLLLLL VSSSFTTTGG DDDFFGKLLD PEEMKHFFGG TTVVVTWWHT TKQVVVA--- LL------EL LLPPLHHPMG IMMMVVVSSL KDLLSSYY-E EGGKAAEVVI EPEPPGGGPP LL------EV VVPPLHHPMG VVVVVVLNNT KDLLSSYY-E EGGKAAEVVI DEQPPGGGPP LL------EV VVPPAHHPYG VVVVVVVDDT TNLLSSRR-E EGGKVVKTTA TPEPPAAAPP LL------EV VVPPAHHPYG VVVVVVVDDT TNLLSSRR-E EGGKAAETTA TPEPPKKKPP LL------EI IIPPAHHPYG CVVVVVVDDT TNLLAAQQKD DGGTAAKTTI TDVPPAAAPP FF------EL LLPPAHHPYG VCCCVVISSL KDLLSSRR-D DDDKVVRVVI EPEAAPPPPP LL------EL LLPPAHHPYG MCCCVVVSSL KDLLSSRR-D DGGSLLKVVI DPEPPEEEPP LL------EL LLPPAHHPYG VVVVVVVSSL EDLLSSRR-Q QGGSIIRVVI EPEPPPPPPP PP-----LEI IIFFLHHPQG VCCCAALSSS NIQQYY---- ---------T WVKVVVVVKK PP-----LEI IIFFLHHPQG VCCCAALSSS NIQQYY---- ---------T WVKVVVVVKK PP-----LEI IIFFLHHPQG VCCCAALSSS TIQQYY---- ---------T WVKVVVVVKK PP-----LEI IIFFLHHPQG VCCCAALSSS TIQQFF---- ---------T WAKVVVVVKK PP-----LEI IIFFLHHPQG VCCCAALSSS TIQQYY---- ---------T WVKVVVVVKK PP-----LEI IIFFLHHPQG VCCCAALSSS TIQQYY---- ---------T WVKVVVVVKK PP-----LEI IIFFLHHPQG VCCCAALSSS TIQQYY---- ---------T WVKVVVVVKK PP-----LEI IIFFLHHPQG VCCCAALSSS TIQQYY---- ---------T WVKVVVVVKK PP-----LEI IIFFLHHPQG VCCCAALSSS TIQQYY---- ---------T WVKVVVVVKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAPPPIILCL LLSSIHHKQD DVVVEEVSSF SGRRSS---- ---------A VLRKKLLLVV PP-----LEI IIFFLHHPQG VCCCAALSSS TVFFYY---- ---------K WAKVVVVVKK PP-----LEI IIFFLHHPQG VCCCAALSSS SIFFYY---- ---------K WAKVVVVVKK PP-----LEI IIFFLHHPTG VSSSAALSSS NMIIFF---- ---------S WHLAAVVVKK PP-----LEI IIFFLHHPTG VSSSAALTTS NMIIFF---- ---------S WHIVVVVVKK PP-----LEI IIFFLHHPTG VSSSAALSSS NMIIFF---- ---------T WYIVVVVVKK PP-----LEI IIFFLHHPTG VSSSAALSSS NMIIFF---- ---------T WHVVVVVVKK PP-----LEV VVFFLHHPTG VCCCAALTTS NMVVFF---- ---------S WHVAAIIIKK PP-----LEV VVFFLHHPHA VCCCAALGGS GIFFHHSS-- ---------T HALVVIIIKK PP-----LEV VVFFLHHPHA VCCCAALGGS AIFFHHPP-- ---------V QALVVIIIKK ---------- ---------- ---------- ---------- ---------- ---------- PP-----LEI IIFFLHHPQG VCCCAAFXXX XXXXXX---- ---------- --------QQ PP-----LEI IIFFLHHPEG VCCCAALNNA KVFFKKDD-- -------FFE AKIDDGGGDD ---------- ---------- ---------- ---------- ---------- ---------- -------LEI IIFFPWWSYA STTTAALTTS QLWWYY---- ---------- -----WWWAA -------LEI IICCAWWEYC TTTTAALTTS QLWWYY---- ---------- -----WWWAA EILLKKKFKA APPPPLLTTT TDIDDDSSLD DDFYLLSGIE VVDSNNPKPV VVLGGGGKKK PVLLKKKFKM MPPPPLLTTT TDIDDDSSLD DDFYVVSGLE LLDTNNPQPR RRLGGGGRRK PLLLQQQFGA APPPPLLTTT TDIDDDSSLD DDFYVVSGTE MMDSDDPNPV VVLGGGGSSR PLLLQQQFGA APPPPLLTTT TDIDDDSSMD DDFYVVSGTE MMDSDDPKPK KKLGGGGSSH DLLLKKKFGA APPPPLLTTT TDIDDDSSLD DDYYVVAGLE MMDSDDPNPV VVLGGGGKKE PVLLKKKFKA APPPPLLTTT TDIDDDSSMD DDFYVVSGTD LLDSDDPEPK KKLGGGGKKR PILLKKKFKA APPPPLLTTT TDINNNSSVD DDFYVVSGTE LLDSDDPNPR RRLGGGGKKQ PLLLKKKFGA APPPPLLTTT TDINNNSSLD DDFYVVSGTE LLDSDDPNPR RRHGGGGSSR VKGGWWWLPE EPGGGLLTTT TDILLLSSLD DDFYFFSLHD IIDSNNPKPR RRLGGGGQQF VKGGWWWLPE EPGGGLLTTT TDILLLSSLD DDFYFFSLHD IIDSNNPKPR RRLGGGGQQF VKGGWWWLPE EPGGGLLTTT TDILLLSSLD DDFYFFSLHD LLDSDDPRPR RRLGGGGQQF VKGGWWWLPE EPGGGLLTTT TDILLLSSLD DDFYFFSLHD IIDSDDPRPR RRLGGGGQQF VKGGWWWLPE EPGGGLLTTT TDILLLSSLD DDFYFFSLHD LLDSDDPRPR RRLGGGGQQF VKGGWWWLPE EPGGGLLTTT TDILLLSSLD DDFYFFSLHD LLDSDDPRPR RRL------- VKGGWWWLPE EPGGGLLTTT T--------- ---------- ---------- ---------- VKGGWWWLPE EPGGGLLTTT TDILLLSSLD DDFYFFSLHD LLDSDDPRPR RRLGGGGQQF VKGGWWWLPE EPGGGLLTTT TDILLLSSLD DDFYFFNLHD MMDSDDPRPR RRLGGGGQQF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VAKKFFFVVS SSNNNEEPPP PPAWWWFFFS DDLIFFL--- ---------- ---------- VEGGWWWLPE EPGGGLLTTT TDILLLSSLD DDFYFFSLHD IIDTDDPNPK KKLGGGGQQF VEGGWWWMPE EPGGGLLTTT TDILLLSSLD DDFYFFSLHD IIDTDDTNPK KKLGGGGQQF VQNNWWWLPE EPGGGLLTTT TDFLLLSSLD DDFYFFVLHD IINEDDLNPV VVLGGGGQQW VQNNWWWLPE EPGGGLLTTT TDFLLLSSLD DDFYFFVLHD IINEDDVNPK KKLGGGGQQW VENNWWWLPE EPGGGLLTTT TDFLLLSSLD DDFYFFVLHD IINEDDPNPV VVLGGGGQQW VENNWWWLPE EPGGGLLTTT TDFLLLSSLD DDFYFFVLHD IINEDDPNPV VVLGGGGQQW VRNNWWWLPE EPGGGLLTTT TDFVVVSSLD DDYYLLVLHD IINEDDPKPV VVLGGGGQQW VSGGWWWLPE EPAAALLTTT TDILLLSSMD DDFYVVSLHD IIDSDDPKVK KKLSSSSQQY VENNWWWLPD DPAAALLTTT TDILLLSSMD DDFYVVSLHD IIDSDDPNPK KKLSSSSQQF ---------- ---------- ---------- ---------- ---------- ---------- GENNGGGIEM MGGGGMMTTT TDILLLSSLD DDYYFFSRHD VVDSDDRNPR RRLGGGGQQF TGSSGGGAED DGGGGMMSSS SDIIIISSLD DDFYVVNRHD VVDTDDPNPK KKLGGGGQQF ---------- ---------- ---------- ---------- ---------- ---------- VADDIIINPA AIPPPLLVVV VDISSSAAAD DDTWIINMDK TTDSDDPKPF FFQYYYYEEV VADDIIIEPA AVPPPLLVVV VDISSSSSND DDRWVVNMDK TTDSDDPHPR RRQYYYYEET KGGIFHRADD ---------- ------AGHH KKTPQLLIIS RGRVVYVVVT NNSSSTTWWD KGGLYHREPP ---------- ------SGAA EETPQIIVVS RGRVVYIIIT NNSSSSSWWN RGGIARRAPP ---------- ------NGRR TTAPQVVIIS RGRVVYWWWT NNSSSTTWWD HGGIARRTPP ---------- ------NGKK AAAPQVVIIS RGRVVYWWWT NNSSSTTWWD EGGIVKKTPP ---------- ------NGKK TTGPQVVIIS RGKVVYWWWT NNSSSTTWWD RGGIVSRATT G--------- -----AKNGG AANPQVVIIS RGRVVYFFFT NNSGGAAVVD QGGIVRRAGG ---------- -----ATSAA EENPQVVIIS RGRVVYFFFT NNSRRAAWWD RGGIVRKAAA ---------- ------ASGG PPNPQVVVVS RGRVVYFFFS NNSAASSWWD FGGSIVRGGG QV-DDDLTCQ QPPPVVKGKK RRPPQIILLS LGKLLYAAAT TTSSSDDWWD FGGSIVKGGG QV-DDDLTCQ QPPPVVKGKK RRPPQIILLS LGKLLYVVVT TTSSSAAWWD FGGSIVKGGG QV-DDDLKSQ QPPPVVKGKK KKPPQIILLS LGKLLYVVVT TTSSSAAWWD FGGSIVKDGG QV-DDDLDSQ QPPPVVKGKK QQAPQIILLS LGKLLYVVVT TTSSSAAWWD FGGSIVKGGG QV-DDDLKSQ QPPPVVKGKK RRAPQIILLS LGKLLYIIIT TTSSSAAWWD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FGGSIVKGGG QV-DDDLKSQ QPPPVVKGKK RRAPQIILLS LGKLLYIIIT TTSSSAAWWD FGGSIVKGGG QV-DDDLKSQ QPPPVVKGKK RRPPQIILLS LGKIIYVVVT TTSSSDDWWD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FGGSILRGGG TV-DDDLECQ QPPPIVKGKK KKPPQIILLS LGKLLYVVVT NNSSSKKWWD FGGSIQRGGG TV-DDDLECQ QPPPTVKGKK IIPPQIILLS LGKIIYVVVT SSSSSIIWWD WGGLIQKGSS AA-EEEKTWQ QSSVEIQGQQ KKRPQIILLT LGKLLYVVVT NNSSSAAWWD WGGLIQKGSS VA-DDDETWQ QSSVEIQGKK KKRPQIILLS LGKLLYVVVT NNSSSAAWWD WGGLLQKGSS KA-EEENSFQ QFFVQIKGKK SSRPQIILLS LGKLLYAAAT NNSSSAAWWD WGGLLQKGSS KA-EEENTFQ QFFVQIKGKK SSRPQIILLS LGKLLYAAAT NNSSSAAWWV WGGLLQKGSS VY-EEEKEEQ QYYVQVKGHH RRRPQIILLS LGKIIYVVVT NNSSSRRWWD YGGSVHTESS KV-GGG---P PIIAYVKGRR KKEPQLLLLS LGKLLYVVVT TTSKKKKWWD FGGSIHSETT KV-EEED--E EIIAYVKGRR QQEPQLLLLS LGKLLYVVVS TTSKKKKWWD ---------- ---------- ---------- ---PAIILLS VGKLLYVVVT NNSSSTTWWD FGGAIQRDAA RV-DDDLKEA APPPFLKGRR RRLPQLLLLS LGRLLYVVVS SSSSSPPWWD FGGAICSDLL VIEDDDLKER RPPAYVKGRR RREPQLLLLS LGKLLYVVVS SSSSSPPWWD ---------- ---------- ---------- ---------- ---------- ---------- VRRQVN---- ---------- ---------- -----VVQQS WGKVVYFFFS SSSAANNWWD TAAQVN---- ---------- ---------- -----VVSSS WGQLLYYYYT SSSAANNWWD QQFFPEGLMK LN--PSSGGL KKKKVVDDDE E------AAH QVVLLSGGGD DAASSSYCCY QQFFP-GLMK VN--PEEGGL KKKKVVDDDR R------AAH QVVLLWGGGD DAASTSFCCY QQFFPDGVQL AH--PDDGGL DDDDVVEEED DG-----YYH QIILLEGGGD DCCSTSFCCY QQFFPDGVEM AN--GNNGGL KKKKVVSSSD DG-----YYH QIILLEGGGD DCCSTSFCCY QQFFPGDRMM AN--ENNGGL KKKKVVDDDA AG-----YYH QIILLEGGGD DCCSTSFCCY QQFFPEGIMK LD--PNNGGI PPPPLLEEEK KG-----HHH QVVLLQGGGD DCCSSSYCCY QQFFPDGIMK VD--PDDGGM PPPPVVDDDE E------QQH QIILLQGGGD DAASSSYCCF QQFFPVGIIK AE--PGGGGL PPPPTTEEED DG-----LLH QIILLEGGGD DSSSSSYCCY QQFF-PDLGV MLDVVNNGGL PPPPVVDDDK KEPLGPPAAH ELLYYPGGGD DCCSSIWII- QQFF-PNLGV MLDVANNGGL PPPPVVDDDK KEPLGPPAAH ELLYYPGGGD DCCSSIWII- QQFF-PDLGV MLDVVKKGGL PPPPVVDDDK KEPLGPPAAH ELLYYPGGGD DCCSSIWLL- QQFF-PDLGV MLDVVKKGGL PPPPVVDDDK KEPLGPPAAH ELLYYPGGGD DCCSSIWLL- QQFF-PDLGV MLDVVKKGGL PPPPVVDDDK KEPLGPPAAH ELLYYPGGGD DCCSSIWII- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQFF-PDLGV MLDVVKKGGL PPPPVVDDDK KEPLGPPAAH ELLYYPGGGD DCCSSIWII- QQFF-PDLGV MLDVVKKGGL PPPPVVDDDK KEPLGPPAAH EIIYYPGGGD DCCTSIWLL- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQFF-PDMGV MLDVEKKGGL PPPPVVDDDK KEPGGPPVVH ELLYYPGGGD DCCSSIWVV- QQFF-PDLGV MLDVKKKGGL PPPPVVDDDK KEPDGPPVVH EIIYYPGGGD DCCTSIWII- QQFF-PGLGH ILDVEKKGGL PPPPVVDDDA AEPDGPPAAH EMMYYPGGGD DCCTSIWII- QQFF-PKLGH ILDVENNGGL PPPPVVDDDA AEPDGPPSSH EMMYYPGGGD DCCTSIWII- QQFF-PELGH IIDVEKKGGL PPPPVVDDDD DEPEGPPAAH EMMYYPGGGD DCCTSIWII- SSFF-PEIGH IIDGEKKGGL PPPPVVDDDD DEPDGPPSSH EMMYYPGGGD DCCTSIWII- QQFFGQDLGH MLDVEKKGGL PPPPVVDDDA AEPEGPPSSH EMMYYPGGGD DCCTSIWII- QQFF-PEHGT MVNIESSGKM RRRRIIDDDK KIEGGPPYYH EMMYYPGGGD DCCTSIWII- QQFF-PENGT MLDVITTGHM KKKKIIDDDK KVPGGPPYYH EMMYYPGGGD DCCTSIWII- QQFF-PNVGV MLDVEKKGGL KKKKVVDDDK KEPNGPPCCH DIIFFPCGGD DSSTSILAA- QQFF-PEMGT IVDIENNGGM EEEEVVDDDG GEPYGPPGGH EMM------- ---------- QQFF-PKMGH IVDVVNNGGI EEEEVVDDDN NEPYGPPSSH EMMYYPGGGD DCCTSIWLLA ---------- ---------- ---------- ---------- ---------- ---------- --------GD DALKNWWDGK EEEEVVDDDE ELGLG----H IMMFFGSSSA ALLYS----- --------GD DELKYWWDGK EEEEIIDDDA AEKLG----H QMMFFGARRA ALLYAPAGGD ------- ------- VKRR--- V------ V------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- A------ ------- ------- RLVVQQA 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSSSAAKQQS TPCRAVPPTL TADDMMSLLL LRRRTQQLLL LLLLLLLTPP SSRIIKKKAY gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------M gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EAAWWSSSSS IQVVVVLPES KKRTTRSVVP PPVVEIISSS VAKPPSSAAA AAWWAWLLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----GLLLL ---------- ---------- ---------- ---------- ---------- --LLLNSSSS ---------- ---------- ---------- ---------- ---------- ---------- GSSAALLLPP LNNNNNRPNP LLPSSPPHHP PPPPLTTRLL RPYNNVVPPR RRCCPHAAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMMM ---------- ---------- ---------- ---------- ---------- ------MMMM ---------- ---------- ------MMVR DTTFSSKKMK APEEDLYYVY YGGTTGGIIN ---------- ---------- --------AP DTTFTTRRDR APEEDIYYVY YGGTTGGVVN ---------- ---------- --------MP DTTFSSEELQ AAEEEFYYTS SDDFFSS--- ---------- ---------- --------MP DTTFSSKKLE AAEENFYYTS SDDFFSS--- ---------- ---------- --------MP DTTFSSKKLE GVEEKLFFTS SDDAASS--- ---------- ---------- --------AP DSSFSSRRLK APEETIYYVD DEERRKK--- ---------- ---------- --------VP DTTFSSRRMK AAEEKLYYVN NMMAANNGG- ---------- ---------- --------AP DTTFSSKKMQ AREERLYYVD DGGRREE--- ---------- ---------- -----ATTTC GGGYPPEEA- GREEEIYYLY YNNTTGGTTE ---------- ---------- ---------- ---------- GREEEIYYLY YNNTTGGIIE LPPPPGKKKK HAAALIIAAP RP-AASTTGC GGGYPPEEA- GREEEIYYLY YNNTTGGIIE ---------- ---------- ---------- ---------- GREEEIYYLY YNNTTGGIIE ---------- ---------- -----ATTGC GGGYPPEEA- GREEEIYYLY YNNTTGGTTE -EEEERAAAA EAFFLQQSSV QPASSATTGC GGGYPPEEA- GREEEIYYLY YNNTTGGTTE ---------- ---------- -----ATTGC GGGYPPEEA- G--------- -------TTE ---------- ---------- -----ATTGC GGGYPPEEA- GREEEIYYLY YNNTTGGTTE LKKKKEEEEE PHTTQPPWWF SWEDDATTGC GGGYPPEEA- GREEEIYYLY YNNTTGGTTE SGGGGCLLLL GDQQNTTEEL TLFTTPTTGC GGGYPPEEA- GREEEIYYLY YNNTTGGTTE ---------- ---------- -----ATTGC GGGYPPEEA- GREEEIYYLY YNNTTGGTTE AHHHHSLLLL VQHHMEEGGA AAAAAGKKCK GGGYPPEEAK GREEKLYYVY YGGTTGGIIN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MAAGC GGGYPPDDA- GREEEIYYLY YSSTTGGIIN ---------- ----MAATTV DVEKKS--GS GGGYPPEES- GREESLYYVY YGGTTGGIIE ---------- ----MGGTTV QVEKKNNNGS GGGYPPEEA- GREETLYYVY YGGTTGGIIE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MG GGGYPPAAA- GSEEKLYYVY YGGTTGGIID ---------- ---------- -AAAAGAACT GGGYPPEEAK GREEKLYYVY YGGTTGGIIN ---------- ---------- -MPNNGLLH- GGGYPPDDA- GREEEVFFV- ---NNAAAAD ---------- ---------- -M---PLLH- GGGYPPDDA- GREEEVFFV- ---HHAARRD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMSC GGGYPPDDAN GVEEKLYYVQ QNNLLDDEEE ---------- ---------- ---------- ---------S GREEKLYYTQ QNNLLDDEEP ---------- ---------- ---------- MGGL--DDIS LDRRFLFFSH HDDIIRRQQY MRRRRREEEE F--------- -A-AAAMMPF AEETSSYYMI TQEEEFYYVG GEEGGMMGGD MRRRRFIIII VGPPMHHFFA RSLAAALLPR AEETSSYYMI TQEEDYYYVG GEEGGVVGGD RAADDDIIAV VVDNKSSSET YSSKKKVHVV VVLPPIDEEL HHACCCCCLL LL-G--KKPN APPDDDLLAV VVDDKSSSPT YGGKKKIYLL LLLPPIDEEL HHACCCCCYY YY-A--KKPF RPPDDDLLAV IIDKGSSSST YGGKKKVHVV VVMPPTDEEF HHACCCCCLL LL-TGGHHAF KPPDDDLLAV IIDKGSSSPT YGGQQQVHVV VVMPPKDEEF HHACCCCCLL LL-AGGHHAF KPPDDDLLAV VVDDTSSSEK FGGQQQVHLL LLMPPKDEEF HHACCCCCLL LL-TGGHHAF QPPDDDIIAV VVDDASSSPR YAASSSVGVV VVMPPADEEL HHACCCCCLL LL-APPHHPH KPPDDDMMCV VVDDQSSSST FGGQQQVGTT TTMPPTGEEL HHACCCCCLL LL-APPHHPH RPPDDDLLGV LLDDDSSSGT YAAQQQVGVV VVMPPADEEL HHACCCCCLL LL-APPHHPH APPDDDLLAT VVDDKSSSPQ YSSQQQIHLL LLMPPLDEEL HHTCCCCC-- ---FGGDDST APPDDDLLAT VVDDKSSSPH YSSQQQIHLL LLMPPLDEEL HHTCCCCC-- ---FGGDDST APPDDDLLAT VVDDKSSSPQ YCCQQQIHLL LLMPPLDEEL HHACCCCC-- ---FGGDDST APPDDDLLAT VVDDKSSSPQ YCCQQQIHLL LLMPPLDEEL HHTCCCCC-- ---YGGDDIT APPDDDLLAT VVDDKSSSPQ YCCQQQIHLL LLMPPLDEEL HHTCCCCC-- ---FGGDDST APPDDDLLAT VVDDKSSSPQ YCCQQQIE-- ---------- ---------- ---------- APPDDDLLAT VVDDKSSSPQ YCCQQQIHLL LLMPPLDEEL HHTCCCCC-- ---FGGDDST APPDDDLLAT VVDDKSSSPQ YCCQQQIHLL LLMPPLDEEL HHTCCCCC-- ---FGGDDST APPDDDLLAT VVDDKSSSPQ YSSQQQIHLL LLMPPLDEEL HHTCCCCC-- ---FGGDDST APPDDDLLAT VVDDKSSSPQ YCCQQQIHLL LLMPPLDEEL HHTCCCCC-- ---FGGDDST APPDDDLLAT VVDDKSSSPQ YCCQQQIHLL LLMPPLDEEL HHTCCCCC-- ---FGGDDST KLLDDDLLAT VVDDSSSSPT YSSQQQIHLL LLVIIIDKKL HHSCCCCC-- ---HGGDDPS ---------- ---------- ---------- --MPPTDEEL HHTCCCCC-- ---YGGDDAS KPPDDDLLAT VVDDKSSSPS YSSQQQIHLL LLMPPVDEEL HHTCCCCC-- ---YGGDDSS KPPDDDLLAT VVDDSSSSPT YSSKKKIHLL LLVPPVDEEL HHSCCCCC-- ---HGGDDPS KPPDDDLLAT VVDDNSSSPT YSSKKKIHLL LLVPPVDEEL HHSCCCCC-- ---HGGDDPS ---------- ---------- ---------- --MPPVDEEL HHSCCCCC-- ---HGGDDAS KPPDDDLLAT VVDDSSSSPS YSSSSSIHLL LLMPPVDEEL HHSCCCCC-- ---HGGDDAS KPPDDDLLGT VVDDNSSSPT YSSQQQIHLL LLVTTVDEEL HHACCCCC-- ---HGGDDPS GPPDDDIIFT VVDNESSSDT FCCQQQISVV VVVPPIDEEV HHACCCCC-- ---HDDKKPT GPPDDDIIFT VVNNESSSET FCCQQQISVV VVVPPIDEEV HHACCCCC-- ---HDDKKPT ---------- ---------- ---------- ---------- ---------- ---------- HGGDDDLLAT VVDDASSSPT YCCQQQIHTT TTTNNKNEEL HHTCCCCCHH HHVGGGKKEV HGGDDDLLST VVDDESSSPT YCCQQQVHTT TTTNNKDEEL HHACCCCCYY YYVSSSKKTV DIITTTRRKN PPRVQVVVFL GGGSSSLKGG GGVKKLDKKE LLPRRRRR-- ----GGKKRV EQQDDDLLVT IIDRGSSSAT RGGQQQINVV VVVGG-NEEA HHA------- ---------- EQQDDDLLVT VVDNKSSSPQ YGGKKKVNLL LLVGG-NEEA HHD------- ---------- NNIIEEELLI IVVPGSRRRI IIIDDDDTKK KPPNPEEEPK IIVEEKKSSL HTVCGPDAII FFLLEEELLI IVVPASRRRI IIVDDDDTKK KPPDKRRRPA VAIEVGGTTY HTVCGPDAII FFLLEEELLI IIIPGSRRRV VVIDDDDTKK KPPHPQQQAR IHIEEAASSP HTVCGPEGII FFIIEEELLI IIIPGSRRRI IIIDDDDTKK KPPDPKKKAK IHIEEKKSSP HTICGPDGII FFLLEEELLI IIIPGSRRRI IIVDDDDVKK K--EPKKKAK IHIEEAASSP HTICGPEGII HHMMEEELLV VVVPGSRRRI IILDDDDTKK KPPDPKKKPF LAVETEESSP HTVCGPGGII HHVVEEELLV VVVPDSHHHI IILDDDDTKK KPPDPQQQPK VVVDEEEAAP HTVCGPDGII HHVVEEELLI IVVPGSRRRI IIVDDDDTKK KPPDPEEEPR IVVEERRSSP HTICGPDGVV TTKKSSSLLI ILLPGSRRRV VVVDDDDVGG GSSEPAAAPK LHVEEAASST HTSCLASGEE TTKKSSSLLI ILLPSSRRRV VVVDDDDVGG GSSEPAAAPK LHVEEAAGGL HTSCLASGEE TTKKSSSLLM MLLPCSRRRV VVVDDDDVGG GSSDPAAAPK LHVEDAAGGV HTSCLASGEE TTKKAAALLV VLLPASRRRV VVVDDDDVGG GTTEPAAAPK LHVEDTTGGF HTSCLPSGEE TTKKSSSLLV VLLPSSRRRV VVVDDDDVGG GSSEPAAAPK LHVEDAAAAL HTSCLASGEE ---------- ---------- ---------- ---------- ----DAAAAL HTSCLASGEE TTKKSSSLLV VLLPSSRRRV VVVDDDDVGG GSSEPAAAPK LHVEDAAAAL HTSCLASGEE TTKKSSSLLV VLLPSSRRRV VVVDDDDVGG GSSEPAAAPK LHVEDAAAAL HTSCLASGEE TTKKSSSLLV VLLPSSRRRV VVVDDDDVGG GTTEPAAAPK LHVEDEEGGP HTSCLPTGEE TTKKSSSLLV VLLPS----- ---------- ---------- ---------- ---------- TTKKSSSLLV VLLPSSRRRV VVVDDDDVGG GSSEPAAAPK LHVEDAAAAL HTSCLASGEE SSAAKKKLLI ILLPSGRRRV VVVDDDDTAA ATTDPTTTPS LHVEDEEGGP HTSCLASGDD SSKKVVVLLI ILLPCSRRRV VVVDDDDVGG GTTDPAAAPR IHTEEWWAAL HTSCLGCGEE SSKKVVVLLI ILLPCSRRRV VVVDDDDVGG GSSDPAAAPR IHTEEWWAAP HTSCLGCGEE SSAAEEELLI IAAPSGRRRV VVIDDDDTKK KTTNPSSSPS LHVDDQQAAP HTSCLASGEE SSAAQQQLLI IVVPGGRRRV VVIDDDDTKK KTTNPAAAPS LHVEDTTAAP HTSCLASGEE SSAADDDLLV VLLPSGRRRA AAIDDDDTKK KEENPAAAPS LYYDEEEAAP HTACLASGEE SSVVDDDLLV VLLPSGRRRA AAIDDDDTKK KEENPAAAPS LYYDEDDAAP HTACRT-GEE SSAASSSLLI ILLPSGRRRV VVVDDDDTLL LKKDPAAAPA LHVEDEEGGP HTSCLASGEE TTEEKKKLLI IVVPCDRRRI IIINNNNVEE ENNE-KKKIY LETEKSSSSP HTSCLADGNN TTEEKKKLLI IVVPCDRRRV VVINNNNVEE ENNE-EEEIY LQTEKAASSP HTSCLADGNN -------MMV VPPRKGVVVK KKVFFFFVGG GGG------- ---------- ---------- VVPPTTTLLV VLLPCDRRRV VVIDDDDTGG GTTDPAAAPK LAVEDKKTTP HTTCLPNGNN VVPPKKKLLV VLLPSDFFFI IILDDDDVVV VTTDPKKKPE IVTDDKKTTP HTTCLANGNN VVQQGGGMML LQQLSKRRRV VVTTTTTSLL LYYSADDDKQ FY--DKKAAS HTAYQPNTAA ----DDDFFW WTTGGNRRRI IIFDDDDVHH HSSDPNNNPK LHTDFDDVVP HTFALPGSMM ----DDDLLW WAAGGSKKKV VVFDDDDVHH HSSDPRRRPV LSTTFKKVVP HTLALPGRMM IYSAN--EGG -EEPPPGILM MMLYFFPPLL GKKWWIGGQQ Q--------- ---LLYYFWL IYSAG--DGG REEPPPGIFL LLLDFFPPII GRRWWVGGQQ Q--------- ---FFYYFWL IYSTGGGDGG TDDAAAPIFI IIMEFFVVLL GRRWWIGGQQ Q--------- ---KKYYFWL IYSTGGGDGG TNNPPPPVFI IIMEFFVVLL GRRWWIGGQQ Q--------- ---LLYYFWL IYSTGGGDGG TDDPPPPIFI IILEFFIILL GRRYYMGGQQ Q--------- ---KKYYFWL IYTAN--EGG -KKPPPGIAM MMLQFFPPLL GRRWWVGGQQ Q--------- ---FFYYGWL IYSAS--EGG -EEPPPGIFI IILDLLVVLL GRRWWIGGQQ Q--------- ---LLYYFWL VYSAS--EGG -DDPPPGVFV VVMEFFPPLL GRRWWVGGQQ Q--------- ---LLYYFWL EVVNG--LQQ GNNKKKGFVL LLLEFFVVKK GTTWWKGGSS S--------- ---MMYYFWP EVISG--PQQ GNNKKKGFVL LLLEFFVVKK GTTWWKGGAA A--------- ---MMYYFWP EVISG--SKK GNNKKKGFVL LLLEFFVVKK GTTWWQGGAA A--------- ---MMYYFWP EVVSG--PEE GNNKKKGFVL LLLKFFVVKK GTTWWQGGAA A--------- ---LLYYFWP EVISG--VKK GNNKKKGFVL LLLEFFVVKK GTTWWRGGAA A--------- ---SSYYFWP EVISG--VKK GNNKKKGFVL LLLEFFVVKK GTTWWRGGAA A--------- ---LLYYFWP EVISG--VKK GNNKKKGFVL LLLEFFVVKK GTTWWRGGAA A--------- ---LLYYFWP EVISG--VKK GNNKKKGFVL LLLEFFVVKK GTTWWRGGAA A--------- ---LLYYFWP EVISG--PKK GNNKKKGFVL LLLEFFVVKK GTTWWRGGAA A--------- ---MMYYFWP ---------- ---------- ---------- ---------- ---------- ---------- EVISG--VKK GNNKKKDSLV VVL-LLCCSS G--------- ---------- ---------- DIISG--KEE GNNAAAGGFL LLLSFFVVKK GRRGGNFFII I--------- ---KKRRHLN EIISG--PYY GNNKKKGFVL LLLEFFVVKK GNNWWAEEAA A--------- ---FFYYFWP EIISG--PCC GNNKKKGFVL LLLEFFVVKK GNNWWVEEAA A--------- ---FFYYFWP ELISG--KDD GNNEEEGGFL LLLSFFVVKK GRRWWKHHPP P--------- ---FFYYFWP EIISG--KDD GNNEEEGGFL LLLSFFVVKK GRRWWKHHPP P--------- ---FFYYFWP EIVSG--EEE GNNKKKGGFL LLLSFFIIKK NRRWWKHHPP P--------- ---FFYYFWP EIVSG--EEE GNNKKKGGLL LLLSFFIIKK NRRWWKIIPP P--------- ---YYYYFWP EIISG--KEE GNNAAAGGFL LLLSFFVVKK GRRWWKHHPP P--------- ---FFYYYWP NIISG--ANN GTTSSSGFLL LLLKFFPPKK GTTWWAKKVV V--------- ---FFYYFWP NIISG--ADD GSSSSSGFLL LLLKFFPPKK GTTWWAKKVV V--------- ---FFYYFWP ---------- ---------- ---------- ---------- ---------- ---------- NIISG--AEE GNNKKKGDFV VVEKFFLLVV GTTWWRRRAA A--------- ---CCYYYWP NIISG--AEE GYYKKKGDFI IILSFFCCII GTTWWKKKAA A--------- ---CCYYFWP ALQDN--SLL SVVVVVLGIQ QQTHNNLLSS AKKGGAFFEE E--------- ---LLLLNHG MMTGN--DDD HGGRRRTLVE EEYDEEVVAA TYYWWPDDMM MGGAVGDDDA ADGYYYYIRI MLTGN--KDD HGGRRRTLVE EEYAEEVVAA THHWWPGGLL LGGKTG---K ADGYYYYVRP LPNNVVVVSS SEEEEEAVVN NN---TIDG- KKKEHLLDD- -RRGGGNNRR RIHFWRRKIH LPSSVIIITS SEEEEETVVR RR---CFEG- SSSECLLEEG GAAGGGNNKK KLHVWRRRLY LPRRYVVVSS SEEEEEALLP PP---QFNG- VVVEDLLAAN NKKGGGHHRR RLHFWRRRVQ LPRRYVVVTS SEEEEEALLP PP---QFNG- VVVEDLLSSN NKKGGGHHRR RLHFWRRRVQ LPRRYVVVSS SEEEEEGLLP PP---QFNG- VVVEDLLSSN NKKGGGHHKK KIHFWRRKVQ LGYYTVVVTS SEEEEEGTTD DD---MVDG- VVVDILLGGA ARRGGGRRRR RLHFWRRRLQ LGYYTLLLTS SEEEEEGTTR RR---MVSG- LLLDELLAAG GKKGGGHHRR RLHVWRRRLQ LGYYTVVVTS SEEEEEGTTN NN---MIGG- DDDQILLNNK KGGGGGRRRR RLHIWRRRLQ PRHHVVVVST TEEEEEAAAN NN---VFDGF PPPHVEE--G GLLGGGSSRR RIFVWHHEIQ PRHHIVVVST TEEEEEAAAN NN---VFDGF PPPHVEE--G GLLGGGSSHH HIHVWHHEIQ PRHHVIIIST TEEEEEAAAN NN---VFDGF PPPDVEE--G GLLGGGSSHH HLHVWHHEIQ PRHHVIIIST TEEEEEAAAN NN---VLDGF PPPDVKK--G GLLGGGSSHH HLYVWRREVQ PRHHVIIIST TEEEEEAAAN NN---VLDGF PPPDVEE--G GLLGGGSSHH HLYVWHHEVQ PRHHVIIIST TEEEEEAAAN NN---VLDGF PPPDVEE--G GLLGGGSSHH HLYVWHHEVQ PRHHVIIIST TEEEEEAAAN NN---VLDGF PPPDVEE--G GLLGGGSSHH HLYVWHHEVQ PRHHVIIIST TEEEEEAAAN NN---VLDGF PPPDVEE--G GLLGGGSSHH HLYVWHHEVQ PRHHVIIIST TEEEEEAAAN NN---VVNGF PPPDVEE--G GLLGGGKKHH HLHVWHHEVQ ---------- ---------- ---------- ---------- ---------- ---------- ---------A AIIIIIAHHN NN---LRTGS DDDPASS--S SRRAAAGGII IT-------- NAWWLWWWSW WIIIIICCCL LL---FYTGA LLLCLTT--S SGGHHHVVII ISCLDRRVDE PRHHVIIIST TEEEEEGAAK KK---AFLGF MMMEVQQ--G GMMGGGHHSS SLNVWHHRIQ PRHHVIIIST TEEEEEGAAK KK---AFLGF MMMDVQQ--G GHHGGGHHSS SLNVWHHRVQ PRHHTIIIST TSSSSSGAAT TT---AFKGF LLLHVAA--G GLLGGGRRHH HLTCIGGERQ PRHHTIIIST TSSSSSGAAK KK---AFQGF LLLHVAA--G GLLGGGRRHH HLHVYGGEKQ PRHHTIIIST TSSSSSGAAK KK---AFKGF LLLHVAA--G GLLGGGSSHH HLHVYGGEKQ PRHHTIIIST TSSSSSGAAK KK---AFKGF LLLHVAA--G GLLGGGSSHH HLHVYGGEKQ PRHHTIIISS SSSSSSGAAA AA---AFTGF LLLHVQQ--G GLLGGGRRHH HLHVYGGEKQ PRRRVIIIST TEEEEEGSSN NN---HIKGF PPPHVGG--G GLLGGGNNSS SVHIFKKKLQ PRRRIIIIST TEEEEEGSSN NN---HIKGF PPPHVPP--G GLLGGGNNSS SVHIFKKKLQ --------SI ILLLLLGGGV VV---TVRDE LLLCQPP--P PLLIIIKKCC CKRVY----- PHFFVVVVAS SEEEEEGAAK KK---LFRGY PPPDCDDRRT TQQGGGCCRR RLNFYRREFQ PYFFVVVVSS SEEEEEGAAN NN---KWRGW NNNDLEEMMS SQQGGGCCRR RLNFYQQTYQ G-RRKEEESD DRRRRRDEEI II---MAESS SSSLKKKGGP PLLPPPQQHH HVAEV----- IRKKVLLLTS SSSSSSTGGS SSNNNMMFGQ LLLDAEEMMK KRRGGGNNTT TIVQWRRQKK PRKKLVVVTS SSSSSSTGGN NNNNNMMFGK LLLDPEEMMK KHHGGGNNTT TVVTWKKQKK HHTGRRRL-- LLRRLLLLLH PTLMGFINMM VVVSKDLSWF GGKWAKKVIE IIPPAAALLL YYDGRRRL-- VVRRLLLLLH PTLMGFVNVV VVLNKDLSWF GGKWARRVID IIEEAAAFFF QQDGQQQL-- VVRRAAAAAH PVEYGFVGVV VVVDTNLGWW GGKFVKKTAT IIPPAAAAAA QQDGQQQL-- VVRRAAAAAH PVEYGFVGVV VVVDTNLAWW GGKFAKKTAT IIPPPPPAAA QQDGQQQL-- IIRRAAAAAH PSDYGFCGVV VVVDTNLGWW GGTFAKKTIT IIDDPPPAAA QQDGQQQF-- LLRRAAAAAH PTAYGFVNCC VVISKDLSWY DDKWVKKVIE IIPPAAAAAA QQDGQQQL-- LLRRAAAAAH PTAYGFMNCC VVVSKDLAWY GGSWLKKVID IIPPAAAAAA QQDGQQQL-- LLRRAAAAAH PATYGFVGVV VVVSEDLAWH GGSWIKKVIE IIPPAAAAAA QQQTGGGP-- IIRRLLLLLH PSTQGFVGCC AALSNIQFEG --------TW SSVVEEEIII QQQKGGGP-- IIRRLLLLLH PDTQGFVGCC AALSNIQFGG --------TW SSVVEEEIII QQTQGGGP-- IIRRLLLLLH PDAQGFVGCC AALSTIQFGG --------TW SSVVEEEIII QQPQGGGP-- IIRRLLLLLH PDAQGFVGCC AALSTIQFDG --------TW SSAAQQQIII QQSKGGGP-- IIRRLLLLLH PDAQGFVGCC AALSTIQFGG --------TW SSVVEEEIII QQSKGGGP-- IIRRLLLLLH PDAQGFVGCC AALSTIQFGG --------TW SSVVEEEIII QQSKGGGP-- IIRRLLLLLH PDAQGFVGCC AALSTIQFGG --------TW SSVVEEEIII QQSKGGGP-- IIRRLLLLLH PDAQGFVGCC AALSTIQFGG --------TW SSVVEEEIII QQLPGGGP-- IIRRLLLLLH PASQGFVGCC AALSTIQFGG --------TW SSVVEEEIII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EEPQQQQANI LLRRIIIIIH KNNQDYDVVV EEVSSGRGAY --------AV VVLLKKKLLL QQDGGGGP-- IIRRLLLLLH PDAQGLVGCC AALSTVFFDG --------KW AAAAEEEIII QQDGGGGP-- IIRRLLLLLH PDDQGLVGCC AALSSIFFDG --------KW AAAAEEEIII QQDGGGGP-- IIRRLLLLLH PADTGFVGSS AALSNMIFDG --------SW SSHHEEEIII QQDGGGGP-- IIRRLLLLLH PADTGFVGSS AALTNMIFDG --------SW NNHHEEEIII QQDGGGGP-- IIRRLLLLLH PSDTGYVGSS AALSNMIFDD --------TW SSYYEEEIII QQDGGGGP-- IIRRLLLLLH PSDTGFVGSS AALSNMIFDE --------TW SSHHEEEIII QQDGGGGP-- VVRRLLLLLH PSDTGYVGCC AALTNMVFDG --------SW SSHHEEEIII QQDPGGGP-- VVRRLLLLLH PTEHAFVGCC AALGGIFIEN -----TT-TH AAAATTTAAA QQDPGGGP-- VVRRLLLLLH PTEHAFVGCC AALGAIFIKN -----KK-VQ TTAASSSAAA ---------- ---------- ---------- ---------- ---------- ---------- QQDGGGGP-- IIRRLLLLLH PRNQGYVGCC AAFXXXXX-- ---------- ---------- QQDGGGGP-- IIRRLLLLLH PKAEGFVGCC AALNKVFFDS -----EEFEA KKKKVVVIII ---------- ---------- ---------- ---------- ---------- ---------- KKNP------ IIRRPPPPPW SNNYAFSTTT AALTQLWIAG ---------- ---------- KKDP------ IIRRAAAAAW EANYCFTSTT AALTQLWIEG ---------- ---------- EEENLLLLLK KAVVPVKLLL SLWWWWGGGR RQYYISNPFP VLLLTGVVVL LGGGFRRHPP EEEPLLLLLK KMVVPVRLLV SLWWWWGGGR RQYYITNPHP RLLLAGVVVI IGGGYRRHPP TTTELLLLLQ GAVVPVRLLV SCWWWWGGGR RQYYVSDPHP VLLLAGVVVI IGGGARRHPP PPPKLLLLLQ GAVVPVRLLV SCWWWWGGGR RQYYVSDPRP KLLLAGVVVI IGGGARRHPP DDDDLLLLLK GACCPVKLLV ACWWWWGGGH HQYYVSDPMP VLLLTGVVVI IGGGVKKHPP DDDQLLLLLK KAVVPVRLLV SCWWWWGGGL LQYYVSDPFP KLLLTGVVVI IGGGVRRHPP SSSQLLLLLK KAVVPVRLLV SCWWWWGGGH HQYYVSDPFP RLLLTGVVVI IGGGVRRHPP EEEQLLLLLK GAVVPVRLLV SCWWWWGGGR RQYYVSDPFP RHHHTGVVVL LGGGVKKHPP QQQSGGGGGW PEMMGIRLLF SNWWWWLGGR RQYYISNPQP RLLLTGIIIL LGGGIRRSVV QQQSGGGGGW PEMMGIRLLF SNWWWWLGGR RQYYISNPKP RLLLTGIIIL LGGGIKKSVV QQQPGGGGGW PEMMGIRLLF SNWWWWLGGR RQYYISDPQP RLLLTGLLLL LGGGIKKPVV QQQPGGGGGW PEMMGIHLLF SNWWWWLGGR RQYYVSDPQP RLLLTGLLLL LGGGIKKPVV QQQPGGGGGW PEMMGIRLLF SNWWWWLGGR RQYYISDPQP RLLLTGLLLL LGGGIKKPVV QQQPGGGGGW PEMMGIRLLF SNWWWWLGGR RQYYISDPQP RLLL------ ---------- QQQPGGGGGW PEMMGI---- ---------- ---------- ---------- ---------- QQQPGGGGGW PEMMGIRLLF SNWWWWLGGR RQYYISDPQP RLLLTGLLLL LGGGIKKPVV EEEPGGGGGW PEMMGIRLLF NNWWWWLGGR RQYYISDPKP RLLLVGIIIL LGGGIKKPVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDDYKKKKKF VSLLNFLIIF LS-------- ---------- ---------- ---------- KKKSGGGGGW PEMMGIRLLF SNWWWWLGGR RQYYITDPRP KLLLVGIIIL LGGGIRRPVV QQQSGGGGGW PEMMGIRLLF SNWWWWLGGR RQYYITDTRP KLLLVGIIIL LGGGIRRPVV PPPPNNNNNW PEMMGIRLLF VNWWWWLGGR RQYYIEDLKP VLLLTGLLLV VGGGIKKPVV SSSPNNNNNW PEMMGIRLLF VNWWWWLGGR RQYYIEDVKP KLLLTGVVVA AGGGIKKPVV SSSPNNNNNW PEMMGIRLLF VNWWWWLGGR RQYYIEDPKP VLLLTGIIIV VGGGLKKPVV SSSPNNNNNW PEMMGIRIIF VNWWWWLGGR RQYYIEDPKP VLLLTGIIIV VGGGLKKPVV SSSPNNNNNW PEMMGIRLLL VNWWWWLGGR RQYYIEDPAP VLLLAGVVVA AGGGLKKEVV FFFSGGGGGW PEMMAIRLLV SCWWWWLGGR RQYYISDPLV KLLLNSVVVI IGGGVTTNVV TTTSNNNNNW PDMMAIRLLV SCWWWWLGGR RQYYISDPKP KLLLNSVVVI IGGGISSTVV ---------- ---------- ---------- ---------- ---------- ---------- ----NNNNNG EMMMGMRLLF SNWWWWRGGR RQYYISDRAP RLLLTGVVVL LGGGIRRPRR PPPLSSSSSG EDMMGIRLLV NCWWWWRGGR RQYYITDPEP KLLLTGLLLL LGGGISSPNN ---------- ---------- ---------- ---------- ---------- ---------- EEEADDDDDI PADDPPQLLI NSFFFFMGGR RLFFISDPHP FQQQIYKKKI IDDRV----- EEEADDDDDI PAKKPPSLLV NTFFFFMGGR RLFFISDPHP RQQQVYKKKI IGGAV----- ---------- ------HGPM EIISSSRRRG RVTNNLLTTW DNYPEEEGLG WMVLNNNANN ---------- ------AGPM SVVSSSRRRG RVTNNLLSSW NNYP---GLG WMAVNNNVNN ---------- ------RGPM EIISSSRRRG RVTNNLLTTW DDYPDDDGVA AQVAHHHAGG ---------- ------KAPM EIISSSRRRG RVTNNLLTTW DDYPDDDGVG VEVANNNVGG ---------- ------KYPM EIISSSRRRG KVTNNLLTTW DEYPGGGDRA AMVANNNVGG G--------- -----AGGPM EIISSSRRRG RVTNNLLAAV DPYPEEEGIG WMVLDDDAGG ---------- -----AAGPM EIISSSRRRG RVTNNLLAAW DEYPDDDGIG WMVVDDDVNN ---------- ------GGPM EVVSSSRRRG RVSNNLLSSW DEYPVVVGIG WIAAEEEADD QLQETTTQPP PPLVVVKGPM QLLSSSLLLG KLTTTLLDDW DKY-PPPDLR EGSMLLLQVV QLQETTTQPP PPLVVVKGPM QLLSSSLLLG KLTTTLLAAW DKY-PPPNLR EGSMLLLQII QLQEKKKQPP PPLVVVKGPM QLLSSSLLLG KLTTTLLAAW DKY-PPPDLR EGSMLLLQII QLQEDDDQPP PPLVVVKGPM QLLSSSLLLG KLTTTLLAAW DKY-PPPDLR EGSMLLLQII QLQEKKKQPP PPLVVVKGPM QLLSSSLLLG KLTTTLLAAW DKY-PPPDLR EGSMLLLQVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QLEEKKKQPP PPLVVVKGPM QLLSSSLLLG KLTTTLLAAW DKY-PPPDLR EGSMLLLQVV QLQEKKKQPP PPLVVVKGPM QLLSSSLLLG KITTTLLDDW DKY-PPPDLR EGSMLLLQII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TLKDEEEQPP PPVIIVKGPM QLLSSSLLLG KLTNNLLKKW DKY-PPPDMK EGSMLLLQII TLKEEEEQPP PPVTTVKGPM QLLSSSLLLG KITSSLLIIW DKY-PPPDLK EGAMLLLQII AIDGTTTQSS SSPEEIQGPM QLLTTTLLLG KLTNNLLAAW DKY-PPPGLE KGSILLLQII VVDGTTTQSS SSPEEIKGPM QLLSSSLLLG KLTNNLLAAW DKY-PPPKLE QGSILLLQII KVDGSSSQFF FFPQQIKGPM QLLSSSLLLG KLTNNLLAAW DRY-PPPELD KGSIIIIQII KVDGTTTQFF FFPQQIKGPM QLLSSSLLLG KLTNNLLAAW VVY-PPPEIE KGSIIIIQII VVDDEEEQYY YYPQQVHGPM QLLSSSLLLG KITNNLLRRW DEYGQQQDLK KGSMLLLQII KLEK---PII IILYYVRGPM QLLSSSLLLG KLTTTLLKKW DDY-PPPEHK SGAMVVVQVV KLDH---EII IILYYVRGPM QLLSSSLLLG KLSTTLLKKW DDY-PPPENR SGAMLLLQII ---------- -------GPK QLLSSSVVVG KLTNNFFTTW DKY-PPPNVK EGSMLLLQII RLPEKKKAPP PPVFFLRGPM QLLSSSLLLG RLSSSLLPPW DKY-PPPEMA AGGIVVVQLL VVKEKKKRPP PPRYYVRGPM QLLSSSLLLG KLSSSLLPPW DKY-PPPKMS QGGIVVVLII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M SQQSSSWWWG KVSSSLLNNW D--------K KGKDAAAQYY ---------- ---------M SSSSSSWWWG QLTSSLLNNW D--------K KGKDEEEQFF NN------PS SSGGGIIDDK FFFVFGEE-- --ARRSVVLS SGDDDAASDS YYYPP----- NN------PE EEGGGLLEEK FFFVFGRR-- --ARRAVVLW WGDDDAATDS FYYPP----- GG------PD DDGGGLLAAD YYWVFPDDG- --YRRAIILE EGDDDCCTDS FYYPPSSVVK GG------GN NNGGGLLDDK YYFVFPDDG- --YRRAIILE EGDDDCCTDS FYYPPSSVV- GG------EN NNGGGLLDDK FFWVFPAAG- --YRRSIILE EGDDDCCTDS FYYPPSSVV- GG------PN NNGGGFFDDP FFFLWPKKG- --HRRPVVLQ QGDDDCCSDS YYYPP----- NN------PD DDGGGFFDDP FFFVFGEE-- --QRRVIILQ QGDDDAASDS YFFPP----- DD------PG GGGGGLLDDP FFFTVGDDG- --LRRPIILE EGDDDSSSDS YYYPPSS--- VVDDDDVVVN NNGGGLLNNP FFLVFGKKEL LPALLALLYP PGDDDCCSDI W--------- IIDDDDVVAN NNGGGLLNNP FFLVFGKKEL LPALLALLYP PGDDDCCSDI W--------- IIDDDDVVVK KKGGGLLNNP FFLVFGKKEL LPALLALLYP PGDDDCCSDI W--------- IIDDDDVVVK KKGGGLLNNP FFLVFGKKEL LPALLALLYP PGDDDCCSDI W--------- VVDDDDVVVK KKGGGLLNNP FFLVFGKKEL LPALLALLYP PGDDDCCSDI W--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVDDDDVVVK KKGGGLLNNP FFLVFGKKEL LPALLALLYP PGDDDCCSDI W--------- IIDDDDVVVK KKGGGLLNNP FFLVFGKKEL LPALLAIIYP PGDDDCCSDI W--------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIDDDDVVEK KKGGGLLNNP FFLVFGKKEG GPVLLALLYP PGDDDCCSDI W--------- IIDDDDVVKK KKGGGLLNNP FFLVFGKKED DPVLLAIIYP PGDDDCCSDI W--------- IIDDDDVVEK KKGGGIINNP FFFVFGAAED DPALLAMMYP PGDDDCCSDI W--------- IIDDDDVVEN NNGGGIINNP FFFVFGAAED DPSLLAMMYP PGDDDCCSDI W--------- IIDDDDVVEK KKGGGIINNP FFFVFGDDEE EPALLAMMYP PGDDDCCSDI W--------- IIDDDDGGEK KKGGGIINNP FFFVFGDDED DPSLLAMMYP PGDDDCCSDI W--------- IIDDDDVVEK KKGGGIINNP FFFVFGAAEE EPSLLAMMYP PGDDDCCSDI W--------- VVNNNNIIES SSGGGIINNR FFLIFGKKIG GPYLLAMMYP PGDDDCCSDI W--------- IIDDDDVVIT TTGGGIINNK FFLIFGKKVG GPYLLAMMYP PGDDDCCSDI W--------- IIDDDDVVEK KKGGGVVNNK FFLVFGKKEN NPCLLAIIFP PCDDDSSSDI L--------- LLDDDDIIEN NNGGGLLNNE FFLVFGGGEY YPGLLPMM-- ---------- ---------- IIDDDDVVVN NNGGGLLNNE FFLVFANNEY YPSLLPMMYP PGDDDCCSDI WAANNDDAA- ---------- ---------- ---------- ---------- ---------- ---------- YYLLLLKKNW WWDDDLLVVE FFAVFYEELL L--RRAMMFG GSAAALLSS- ---------- FFLLLLKKYW WWDDDLLKKE FFAIFYAAEL L--RRPMMFG GAAAALLAGP ADDGGNNRRL ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AARRVEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNAAAAKKKK KSSEAATTPC RTAVPTGGLT AARRLGGGMM LPPTTALLLL LSLLLTPPPS gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PVVVRIIKKY YYYQQEAAWW SAAILASSSR RRRSGGKRVP GIIISAAVAK SSAQQHWLPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MGLGK ---------- ---------- ---------- ---------- ---------- -----KNSQG ---------- ---------- ---------- ---------- ---------- ---------- ---------M MMMAAGRSAA LPPLRTPTTH HHHPAAAPHP RTTTLVVRPY VVPPPPHARH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MKR ---------- ---------- ---------- ---------- ---------- -------MKR ---------- --------MA IVVVFKRRDP TTFFPPSMMK KAPPPPDAAV ALGGTTTGGI ---------- ---------- MAAALKPPDP TTFFPPTMMR RAPPPPDAAV ALGGTTTGGV ---------- ---------- -MMMMRPPDP TTFFAASMMQ QAPPAAEAAT LLDDFFFSS- ---------- ---------- -MMMMRPPDP TTFFAASMME EAPPAANAAT LLDDFFFSS- ---------- ---------- -MMMLRPPDP TTFFPPSMME EGPPVVKAAT LLDDAAASS- ---------- ---------- MAAAWKPPDP SSFFPPSAAK KAPPPPTAAV AFEERRRKK- ---------- ---------- MVVVWRPPDP TTFFPPSVVK KAPPAAKAAV VLMMAAANNG ---------- ---------- MAAAWRPPDP TTFFPPSMMQ QAPPRRRGGV ALGGRRREE- ---------- --------TK CTTT--CCGP GGYYTTPKK- -GPPRREVVL PINNTTTGGT ---------- ---------- ---------- -------MM- -GPPRREVVL PINNTTTGGI GKHGGVLLIA APLPPGG-TQ CGGG--CCGP GGYYSSPKK- -GPPRREVVL PINNTTTGGI ---------- ---------- ---------- -------KK- -GPPRREIIL PINNTTTGGI ---------- --------TK CGGG--CCGP GGYYTTPKK- -GPPRREVVL PINNTTTGGT RAEGGTLLQS SVMPPIIATK CGGG--CCGP GGYYTTPKK- -GPPRREVVL PINNTTTGGT ---------- --------TK CGGG--CCGP GGYYTTPKK- -G-------- ---------T ---------- --------TK CGGG--CCGP GGYYTTPKK- -GPPRREVVL PINNTTTGGT EEPGGAQQPW WFQWWQQETK CGGG--CCGP GGYYTTPKK- -GPPRREVVL PINNTTTGGT CLGFFTNNTE ELCLLVVFTK CGGG--CCGP GGYYTTPKK- -GPPRREVVL PINNTTTGGT ---------- --------TK CGGG--CCGP GGYYTTPKK- -GPPRREVVL PINNTTTGGT SLVLLIMMEG GAEAAAAAKT CCCCTAKKGP GGYYTTPEEK KGPPRRKVVV TVGGTTTGGI ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AK CGGG--CCGP GGYYSSPKK- -GPPRREVVL PISSTTTGGI ------MMAT TVGVVNNE-V NGGGCKSSGP GGYYSSPSS- -GPPRRSIIV TVGGTTTGGI ------MMGT TVAVVSSENQ QGGGCKSSGP GGYYSSPSS- -GPPRRTIIV TVGGTTTGGI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RMMMQVGGGP GGYYTTPSS- -GPPSSKIIV TVGGTTTGGI ---------- ---AAAAAAA CCCCGATTGP GGYYTTPEEK KGPPRRKLLV TVGGTTTGGI ---------- ---MMSSPLK CHHH----GP GGYYSSPKK- -GPPRRELLV TP--NNNAAA ---------- ---MMPP-LK CHHH----GP GGYYSSPKK- -GPPRRELLV TP--HHHAAR ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MS ESSSCKCCGP GGYYTTPRRN NGPPVVKLLV VVNNLLLDDE ---------- ---------- ---------- -------RRS SGPPRRKLLT VVNNLLLDDE ---------- ---------- --------MP GGLLTT-IIS SLDDDDFYYS NLDDIIIRRQ REFGG----- --LAAGG-MG LPPPRAFFAD EETTQQSKKI ITGGQQEVVV WLEEGGGMMG FIVSSSMMHF FALSSGGLLA APPPGVRRAD EETTAASKKI ITGGQQDVVV WLEEGGGVVG IINDDDFFII DDNNPSYIVK VVEPYYINDD EHHFGGWWWC SSSAACC-G- -PPNIERRRF VVNDDDFFLL DDDDPSYVIK LLDPYYIGDD EHHFGGWWWC SSSAACC-A- -PPFLERRRY ---DDDAALL DDKKPSYIVT VVTPNNTGDD EHHFGGWWWC SSSSSSS-TG GAAFLERRRF ---DDDAALL DDKKPSYIVT VVTPNNKGDD EHHFGGWWWC SSSAASS-AG GAAFIERRRY ---DDDGGLL DDDDPSFIVQ LLIPNNKGDD EHHFGGWWWC SSSAASS-TG GAAFLERRRY ---DDDAAII DDDDPSYIVQ VVAPHHAGDD EHHFGGWWWC SSSCCCC-AP PPPHMERRRY GG-DDDAAMM DDDDSSFVVV TTDPYYTGGG EHHFGGWWWC SSSMMCC-AP PPPHVERRRY ---DDDAALL DDDDPSYIVR VVEPNNAADD EHHFGGWWWC SSAAACC-AP PPPHVERRRY TTEDDDYYLL DDDDPSYVIR LLPPYYLKDD EHHSGGWWWC SSSCC---FG GSSTKSRNNK IIEDDDYYLL DDDDPSYVIR LLPPHHLKDD EHHSGGWWWC SSSCC---FG GSSTKSRDDK IIEDDDYYLL DDDDPSYVIR LLPPNNLRDD EHHSGGWWWC SSSCC---FG GSSTKSRTTK IIEDDDYYLL DDDDPSYVIR LLPPHHLKDD EHHSGGWWWC SSSCC---YG GIITKARTTK TTEDDDYYLL DDDDPSYVIR LLPPNNLKDD EHHSGGWWWC SSSCC---FG GSSTKSRTTK TTEDDDYYLL DDDDPSYVI- ---------- ---------- ---------- ---------- TTEDDDYYLL DDDDPSYVIR LLPPNNLKDD EHHSGGWWWC SSSCC---FG GSSTKSRTTK TTEDDDYYLL DDDDPSYVIR LLPPNNLKDD EHHSGGWWWC SSSCC---FG GSSTKSRTTK TTEDDDYYLL DDDDPSYVIR LLPPYYLKDD EHHSGGWWWC SSSCC---FG GSSTKSRNNK TTEDDDYYLL DDDDPSYVIR LLPPNNLKDD EHHSGGWWWC SSSCC---FG GSSTKSRTTK TTEDDDYYLL DDDDPSYVIR LLPPNNLKDD EHHSGGWWWC SSSCC---FG GSSTKSRTTK IINDDDYYLL DDDDPSYVIR LLPIHHIGDD KHHSGGWWWC SSSCC---HG GPPSAKRRRF ---------- ---------- ---PNNTNDD EHHSGGWWWC SSSCC---YG GAASKVRNNK IINDDDYYLL DDDDPSYVIR LLPPNNVNDD EHHSGGWWWC SSSCC---YG GSSSKVRNNK IIEDDDYYLL DDDDPSYVIR LLPPYYVGDD EHHTGGWWWC SSSCC---HG GPPSAERRRF IIEDDDYYLL DDDDPSYVIR LLPPYYVGDD EHHTGGWWWC SSSCC---HG GPPSAQRRRF ---------- ---------- ---PFFVGDD EHHSGGWWWC SSSCC---HG GAASADRRRY IIDDDDYYLL DDDDPSYVIR LLPPFFVGDD EHHSGGWWWC SSSCC---HG GAASVDRRRY IINDDDYYLL DDDDPSYVIR LLPTHHVGDD EHHSGGWWWC SSSCC---HG GPPSASRRRF AADDDDAAII DDNNPSFVIR VVDPHHIGDD EHHTGGWWWC SSSCC---HD DPPTEKRSSH RRDDDDAAII NNNNPSFIIR VVDPNNIGDD EHHTGGWWWC SSSCC---HD DPPTEKRSSH ---------- ---------- ---------- ---------- ---------- ---------- EEEDDDYYLL DDDDPSYVIR TTYNSSKHNN EHHSGGWWWC SSSCCFFVGG GEEVPTRDDR EEPDDDYYLL DDDDPSYIVR TTFNRRKGDD EHHSGGWWWC SSSCCYYVSS STTVPKRDDR QQYTTTDDRR RRVVGVGVLD GGPKVVLEDD KLDSQQPPPR IILKK----G GRRVQGGPPQ GGDDDDKKLL DDRRPSRVIS VVSGGG-RNN EHHGGGFFF- ---------- -----DRRRF GGDDDDKKLL DDNNPSYVVT LLSGGG-RNN EHHSDDFFF- ---------- -----DRRRY IVVGLRSSRI IIDDPRPKII KKKKIIIEPE EKKKKKKKKV SSSRRRLLHV VHHGAIILNE IVVALRSSRI IVDDKRPAVA KKKKVVVEPV VVVVVGGGGR TTTKKKYYHV VHHGAIILGP IIIGLRSSRI VIDDPTARIH KKKKIIIEPE ELLLLAAAAK TTSRRRPPHV VHHGGIVLGA IIIGLRSSRI IIDDPTAKIH KKKKIIIEPE EFFFFKKKKK TTSRRRPPHI IHHGGIVLGG IIIGIRSSRI IVDDPLAKIH KKKKIIIEPE EFFFFAAAAK TTSRRRPPHI IHHGGIVLGG VVVGLRSSRI ILDDPLPFLA KKKKIIIEPT TAAAAEEEER TTSRRRPPHV VHHGGIVLNA VVVDIRSSHI ILDDPTPKVV KKKKIIIDPE EAAAAEEEER TTARRRPPHV VHHGGIILSP IVVGIRSSRI IVDDPRPRIV KKKKIIIEPE EHHHHRRRRR TTSRRRPPHI IHHGGVVLSP ILLGLMSSRI VVDDPRPKLH KKKKIIIEAE EQQQQAAAAK CCSNNNTTHS SHHLGEMTGD ILLSIISSRI VVDDPRPKLH KKKKIIIEPE EHHHHAAAAK CCGNNNLLHS SHHLGEMSGD MLLCLMSSRI VVDDPRPKLH KKKKIIIEAD DHHHHAAAAK CCGYYYVVHS SHHLGEMTGD VLLALISSRI VVDDPRPKLH KKKKIIIEPD DHHHHTTTTK CCGFFFFFHS SHHLGEMTGD VLLSLISSRI VVDDPRPKLH KKKKIIIEPD DHHHHAAAAK CCAFFFLLHS SHHLGEMSGD ---------- ---------- --------PD DHHHHAAAAK CCAFFFLLHS SHHLGEMSGD VLLSLISSRI VVDDPRPKLH KKKKIIIEPD DHHHHAAAAK CCAFFFLLHS SHHLGEMSGD VLLSLISSRI VVDDPRPKLH KKKKIIIEPD DHHHHAAAAK CCAFFFLLHS SHHLGEMSGD VLLSFISSRI VVDDPRPKLH KKKKIIIEAD DHHHHEEEEK CCGTTTPPHS SHHLGEMTGD VLLSL----- ---------- ---------- ---------- ---------- ---------- VLLSLISSRI VVDDPRPKLH KKKKIIIEPD DHHHHAAAAK CCAFFFLLHS SHHLGEMSGD ILLSLLSGRV VVDDPRPSLH KKKKVVVESD DAAAAEEEEN IIGFFFPPHS SHHLGDMCGD ILLCLISSRI VVDDPRPRIH KKKKVVVEPE EFFFFWWWWK CCANNNLLHS SHHLGEMSGD ILLCLISSRI VVDDPRPRIH KKKKVVVEPE EFFFFWWWWK CCANNNPPHS SHHLGEMSGD IAASLVSGRI VIDDPRPSLH KKKKVVVDPD DIIIIQQQQK TTAYYYPPHS SHHLGEMCGD IVVGIVSGRV VIDDPRPSLH KKKKVVVEPD DSSSSTTTTK TTAYYYPPHS SHHLGEMCGD VLLSLISGRI AIDDPRPSLY KKKKVVVDPE EAAAAEEEEK TTAYYYPPHA AHHLGELCGD VLLSLISGRI AIDDPRPSLY KKKKVVVDPE EAAAADDDDK TTAFFFPPHA AHHRGELCGD ILLSLLSGRV VVDDPRPALH KKKKVVVEAD DAAAAEEEEK TTGFFFPPHS SHHLGEMCGD IVVCLNSDRI IINN-RIYLE HHHHIIIEPK KHHHHSSSSL NNSFFFPPHS SHHLGNMTGE IVVCLNSDRI VINN-RIYLQ HHHHIIIEPK KHHHHAAAAL NNSFFFPPHS SHHLGNMTGE VPPKLSSGVE KVFF------ ---------- ---------- ---------- ---------- VLLCLNSDRI VIDDPRPKLA KKKKIIIEGD DLLLLKKKKG AATAAAPPHT THHLGNMIGD VLLSLNSDFI ILDDPRPEIV KKKKIIIDGD DLLLLKKKKS HHTAAAPPHT THHLGNMVGD LQQSLDGKRL VTTTAWKQFY PPPP-----D DIIIIKKKKF LLAIIISSHA ADDQTAKGNE WTTGLDTNRI IFDDPSPKLH KKKKIIIDTF FKKKKDDDDS GGVGGGPPHF FFFLSMILND WAAGLDTSKI VFDDPAPVLS KKKKIIITDF FEEEEKKKKS GGVGGGPPHL LYYLRMILNN EE----G--- -EEGPPGIIL MMMMLDDHFE PLKWEIDQQY ---------- ------YWWN PP----GRRR REEGPPGIIF LLLLLDDHFE PIRWEVPQQY ---------- ------YWWN AAGGKKGTTT TDDGAAGIIF IIIIMDDCFD VLRWEIPQQD ---------- ------YWWN GGGGKKGTTT TNNGPPGVVF IIIIMDDCFE VLRWEIPQQT ---------- ------YWWN GGGGEEGTTT TDDGPPGIIF IIIILDDCFE ILRYEMEQQT ---------- ------YWWN AA----G--- -KKGPPGIIA MMMMLDDAFE PLRWEVPQQY ---------- ------YWWH PP----G--- -EEGPPGIIF IIIILDDHLE VLRWEIDQQY ---------- ------YWWH PP----G--- -DDGPPGVVF VVVVMDDHFD PLRWEVPQQQ ---------- ------YWWH DD----QGGG GNNGKKSFFV LLLLLDDGFE VKTWEKASSP ---------- ------YWWQ DD----QGGG GNNGKKGFFV LLLLLDDGFE VKTWEKEAAP ---------- ------YWWQ DD----KGGG GNNGKKGFFV LLLLLDDGFE VKTWEQAAAP ---------- ------YWWQ DD----EGGG GNNGKKGFFV LLLLLDDGFE VKTWEQAAAP ---------- ------YWWQ DD----KGGG GNNGKKGFFV LLLLLDDGFE VKTWERAAAP ---------- ------YWWQ DD----KGGG GNNGKKGFFV LLLLLDDGFE VKTWERAAAP ---------- ------YWWQ DD----KGGG GNNGKKGFFV LLLLLDDGFE VKTWERAAAP ---------- ------YWWQ DD----KGGG GNNGKKGFFV LLLLLDDGFE VKTWERAAAP ---------- ------YWWQ DD----KGGG GNNGKKGFFV LLLLLDDGFE VKTWERSAAP ---------- ------YWWQ ---------- ---------- ---------- ---------- ---------- ---------- DD----KGGG GNNGKKGSSL VVVVLLLPLE CS-------- ---------- ---------- DD----EGGG GNNAAANGGF LLLLLLLDFN VKRGSNPIIS ---------- ------RLLE DD----YGGG GNNGKKGFFV LLLLLDDGFE VKNWEAAAAP ---------- ------YWWQ DD----CGGG GNNGKKGFFV LLLLLDDGFE VKNWEVSAAQ ---------- ------YWWQ DD----DGGG GNNAEENGGF LLLLLLLDFN VKRWEKSPPL ---------- ------YWWQ DD----DGGG GNNAEENGGF LLLLLLLDFN VKRWEKSPPL ---------- ------YWWQ DD----EGGG GNNAKKNGGF LLLLLLLDFN IKRWEKSPPL ---------- ------YWWQ DD----EGGG GNNAKKNGGL LLLLLLLDFN IKRWEKSPPL ---------- ------YWWQ DD----EGGG GNNAAANGGF LLLLLLLDFN VKRWEKSPPL ---------- ------YWWQ EE----NGGG GTTPSSNFFL LLLLLDDGFE PKTWPATVVP ---------- ------YWWQ EE----DGGG GSSPSSNFFL LLLLLDDGFE PKTWPAVVVP ---------- ------YWWQ ---------- ---------- ---------- ---------- ---------- ---------- DD----EGGG GNNAKK-DDF VVVVEFFDFE LVTWSRKAAL ---------- ------YWWQ DD----EGGG GYYAKK-DDF IIIILFFDFN CITWTKKAAL ---------- ------YWWQ EE----LSSS SVVPVVNGGI QQQQTSSKNG LSKGEAEEEI ---------- ------LHHN DD----DHHH HGGGRRALLV EEEEYNNDEY VAYWMPDMMQ VVAAAGDDDD DDAADGYRRL NN----DHHH HGGGRRALLV EEEEYTTNEY VAHWIPDLLR IIKKKG---- --AADGYRRL N-PNNNEEEV VVVWWPNNN- -II-KLHHLL DDRYGNRIIH HFWWDDKRRK KKRRHHSTTL N-PSSSGGGV VIIWWPRRR- -FF-SLCCLL EEAYGNKLLH HVWWDDKRRR RRHHYYADDL N-PRRRDDDY YVVWWPPPP- -FF-VPDDLL AAKYGHRLLH HFWWDDARRR RRNNQQTDDL N-PRRRDDDY YVVWWPPPP- -FF-VPDDLL SSKYGHRLLH HFWWDDARRR RRNNQQTDDL N-PRRRDDDY YVVWWPPPP- -FF-VPDDLL SSKYGHKIIH HFWWKKDRRK KKNNQQTDDL H-GYYYDDDT TVVWWPDDD- -VV-VPIILL GGRYGRRLLH HFWWDDRRRR RRHHQQEDDF H-GYYYDDDT TLLWWPRRR- -VV-LGEELL AAKYGHRLLH HVWWDDRRRR RRHHQQTDDL H-GYYYDDDT TVVWWPNNN- -II-DPIILL NNGYGRRLLH HIWWDDRRRR RRHHQQADDV Q-RHHHNNNV VVVWWPNNN- -FFFPAVVEE --LYGSRIIF FVWWDDRHHE EEIIQQTQQM Q-RHHHNNNI IVVWWPNNN- -FFFPAVVEE --LYGSHIIH HVWWDDRHHE EEIIQQTQQM Q-RHHHNNNV VIIWWPNNN- -FFFPAVVEE --LYGSHLLH HVWWDDRHHE EEIIQQTTTL Q-RHHHNNNV VIIWWPNNN- -LLFPAVVKK --LYGSHLLY YVWWDDRRRE EEIIQQTPPL Q-RHHHNNNV VIIWWPNNN- -LLFPAVVEE --LYGSHLLY YVWWDDHHHE EEIIQQTSSL Q-RHHHNNNV VIIWWPNNN- -LLFPAVVEE --LYGSHLLY YVWWDDRHHE EEIIQQTSSL Q-RHHHNNNV VIIWWPNNN- -LLFPAVVEE --LYGSHLLY YVWWDDRHHE EEIIQQTSSL Q-RHHHNNNV VIIWWPNNN- -LLFPAVVEE --LYGSHLLY YVWWDDRHHE EEIIQQTSSL Q-RHHHNNNV VIIWWPNNN- -VVFPAVVEE --LYGKHLLH HVWWDDRHHE EEIIQQTLLM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---SSSNNN- -RRSDYAASS --RVAGITT- ---------- ---------- EYAWWWGGGL LWWQQSLLL- -YYALMLLTT --GVHVISSC CLDDNNMRRV VVIIEESPPL Q-RHHHNNNV VIIWWPKKK- -FFFMEVVQQ --MYGHSLLN NVWWDDEHHR RRRRQQTDDL Q-RHHHNNNV VIIWWPKKK- -FFFMEVVQQ --HYGHSLLN NVWWDDEHHR RRLLQQTDDL Q-RHHHNNNT TIIWWPTTT- -FFFLQVVAA --LYGRHLLT TCIIQQRGGE EELLQQTDDL Q-RHHHNNNT TIIWWPKKK- -FFFLQVVAA --LYGRHLLH HVYYSSGGGE EEIIQQTDDL Q-RHHHKKKT TIIWWPKKK- -FFFLQVVAA --LYGSHLLH HVYYSSGGGE EEMMQQLDDL Q-RHHHKKKT TIIWWPKKK- -FFFLQVVAA --LYGSHLLH HVYYSSGGGE EEIIQQLDDL Q-RHHHKKKT TIIWWPAAA- -FFFLQVVQQ --LYGRHLLH HVYYDDGGGE EELLQQTDDL Q-RRRRNNNV VIIWWPNNN- -IIFPAVVGG --LYGNSVVH HIFFEESKKK KKYYQQTDDL Q-RRRRNNNI IIIWWPNNN- -IIFPAVVPP --LYGNSVVH HIFFEETKKK KKHHQQTDDL ---------- ---RRPVVV- -VVELKQQPP --LVIKCKKR RVYY------ ---------- Q-HFFFNNNV VVVWWPKKK- -FFYPTCCDD RRQYGCRLLN NFYYRRERRE EELLQQTDDL Q-YFFFDDDV VVVWWPNNN- -WWWNVLLEE MMQYGCRLLN NFYYKKTQQT TTLLQQTDDL N--RRREEEK KEEPPPIII- -AASSFKKKK GGLKPQHVVA AEVVLL---- ---------- L-RKKKNNNV VLLFFWSSSN YMMQLQAAEE MMRFGNTIIV VQWWDDTRRQ QQPPKKVNNV L-RKKKNNNL LVVFFWNNNN YMMKLAPPEE MMHFGNTVVV VTWWDDTKKQ QQPPKKVDDV LEEEENAAL- ----EELLRR PHHHHLMGFI INVVLDLSSS IWLLLYY-DG GKKWNNAAAE LQQQEHVVL- ----EEVVRR PHHHHLMGFV VNVLTDLSSS IWLLLYY-DG GKKWQQAAAE LAAAQHAAL- ----EEVVRR PHHHHEYGFV VGVVTNLGGG IWTTTRR-GG GKKFHHVVVK LAAANHAAL- ----EEVVRR PHHHHEYGFV VGVVTNLAAA IWTTTRR-GG GKKFHHAAAE LAAANHAAL- ----EEIIRR PHHHHDYGFC CGVVTNLGGG IFTTTQQKDG GTTFEEAAAK FDDDEHVVF- ----EELLRR PHHHHAYGFV VNVILDLSSS IWTTTRR-KD DKKWAAVVVR LAAAEYAAL- ----EELLRR PHHHHAYGFM MNVVLDLAAA IWLLLRR-NG GSSWHHLLLK VEEEEHVVL- ----EELLRR PHHHHTYGFV VGVVLDLAAA VWLLLRR-NG GSSWGGIIIR M----DIIP- ----EEIIRR FHHHHTQGFV VGALSIQFFF KNEEE----- ---------- M----DIIP- ----EEIIRR FHHHHTQGFV VGALSIQFFF KNEEE----- ---------- L----DIIP- ----EEIIRR FHHHHAQGFV VGALSIQFFF KNQQQ----- ---------- L----DIIP- ----EEIIRR FHHHHAQGFV VGALSIQFFF KNEEE----- ---------- L----DIIP- ----EEIIRR FHHHHAQGFV VGALSIQFFF KNEEE----- ---------- L----DIIP- ----EEIIRR FHHHHAQGFV VGALSIQFFF KNEEE----- ---------- L----DIIP- ----EEIIRR FHHHHAQGFV VGALSIQFFF KNEEE----- ---------- L----DIIP- ----EEIIRR FHHHHAQGFV VGALSIQFFF KNEEE----- ---------- M----DIIP- ----EEIIRR FHHHHSQGFV VGALSIQFFF KNEEE----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- L----DGGAN NIIICCLLRR SHHHHNQDYD DVEVFGRGGG DPDDD----- ---------- LEEE-DIIP- ----EEIIRR FHHHHAQGLV VGALSVFFFF KEKKK----- ---------- LKKK-DIIP- ----EEIIRR FHHHHDQGLV VGALSIFFFF KEKKK----- ---------- LNNN-TLLP- ----EEIIRR FHHHHDTGFV VGALSMIFFF KTQQQ----- ---------- LDDD-KLLP- ----EEIIRR FHHHHDTGFV VGALSMIFFF KTQQQ----- ---------- LEEE-TLLP- ----EEIIRR FHHHHDTGYV VGALSMIFFF KNSSS----- ---------- LPPP-TLLP- ----EEIIRR FHHHHDTGFV VGALSMIFFF KNSSS----- ---------- LSSS-TLLP- ----EEVVRR FHHHHDTGYV VGALSMVFFF KTAAA----- ---------- LQQQPLLLP- ----EEVVRR FHHHHEHAFV VGALSIFIII PVEEESS--- ---------- LMMMPRLLP- ----EEVVRR FHHHHEHAFV VGALSIFIII PDEEEPP--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LDDD-DTTP- ----EEIIRR FHHHHNQGYV VGAFXXXXXX ---------- ---------- LSSS-DTTP- ----EEIIRR FHHHHAEGFV VGALAVFFFF KKSSSDD--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VGGGAP---- ----EEIIRR FWWWWNYAFS STALSLWIII EDDDD----- ---------- VGGGAP---- ----EEIIRR CWWWWNYCFT TSALSLWIII EDGGG----- ---------- VVIAAEPLEG LLPPIILFFF KKAAVPPPTD DDSLDDDDKK FFLYYSLLWI EQYDKKPVLL VVIAAQPFEG LLPPVVLFFF KKMMVPPPTD DDSLDDDDRR FFLYYSLLWL EQYDQQPRLL TTAAAEPATA LLPPLLLFFF GGAAVPPPTD DDSLDDDDRR FFLYYSCCWT EQYDNNPVLL TTAPPEPAPK LLPPLLLFFF GGAAVPPPTD DDSMDDDDRR FFLYYSCCWT EQYDKKPKLL TTIPPVPADA LLPPLLLFFF GGAACPPPTD DDSLDDDDKK YYLYYACCWL EQYDNNPVLL VVIAAEAADP LLPPVVLFFF KKAAVPPPTD DDSMDDDDRR FFLYYSCCWT DQYDEEPKLL VVIAAEPASE LLPPIILFFF KKAAVPPPTD NNSVDDDDRR FFLYYSCCWT EQYDNNPRLL VVIAAEPAEP LLPPLLLFFF GGAAVPPPTD NNSLDDDDRR FFLYYSCCWT EQYDNNPRHH --TEEKVIQV KKKKKKGLLL PPEEMPGGTD LLSLDDDDRR FFLYYSNNWH DQYDKKPRLL --TEEKVIQV KKKKKKGLLL PPEEMPGGTD LLSLDDDDRR FFLYYSNNWH DQYDKKPRLL --TEEKVIQV KKKKKKGLLL PPEEMPGGTD LLSLDDDDRR FFLYYSNNWH DQYDRRPRLL --TQQKVIQV KKKKKKGLLL PPEEMPGGTD LLSLDDDDHH FFLYYSNNWH DQYDRRPRLL --TEEKVIQV KKKKKKGLLL PPEEMPGGTD LLSLDDDDRR FFLYYSNNWH DQYDRRPRLL --TEEKVIQV KKKKKKGLLL PPEEMPGGTD LLSLDDDDRR FFLYYSNNWH DQYDRRPRLL --TEEKVIQV KKKKKKGLLL PPEEMPGGT- ---------- ---------- ---------- --TEEKVIQV KKKKKKGLLL PPEEMPGGTD LLSLDDDDRR FFLYYSNNWH DQYDRRPRLL --TEEKVIEV KKKKKKGLLL PPEEMPGGTD LLSLDDDDRR FFLYYNNNWH DQYDRRPRLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AKKRKLDL AAVVAAKVVV VVSSLSNNPP WWFFSDDDLL LLIIILSS-- ---------- --KEEKVIKV KKKKEEGLLL PPEEMPGGTD LLSLDDDDRR FFLYYSNNWH DQYDNNPKLL --KEEKVIQV KKKKEEGMMM PPEEMPGGTD LLSLDDDDRR FFLYYSNNWH DQYDNNPKLL --SEELAIPV LLKKQQNLLL PPEEMPGGTD LLSLDDDDRR FFLYYVNNWH DQYNNNPVLL --SEEIVISV LLKKQQNLLL PPEEMPGGTD LLSLDDDDRR FFLYYVNNWH DQYNNNPKLL --TEEIVISV LLKKEENLLL PPEEMPGGTD LLSLDDDDRR FFLYYVNNWH DQYNNNPVLL --TEEVVISV LLKKEENLLL PPEEMPGGTD LLSLDDDDRR FFIYYVNNWH DQYNNNPVLL --SEEVAISI LLKKRRNLLL PPEEMPGGTD VVSLDDDDRR YYLYYVNNWH DQYNKKPVLL --TTTLVAFI KKKKSSGLLL PPEEMPAATD LLSMDDDDRR FFLYYSCCWH DQYDKKVKLL --VSSLVATI KKKKEENLLL PPDDMPAATD LLSMDDDDRR FFLYYSCCWH DQYDNNPKLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- --QQEENIII EEMMMGGGTD LLSLDDDDRR YYLYYSNNWH DQYDNNPRLL FFEVVIDIPG VVDDGGSAAA EEDDMGGGSD IISLDDDDRR FFLYYNCCWH DQYDNNPKLL ---------- ---------- ---------- ---------- ---------- ---------- --------EW KKAAAADNNN PPAADIPPVD SSAADDDDQQ TTLWWNSSFD KLFDKKPFQQ --------EW KKAAAADEEE PPAAKVPPVD SSSNDDDDSS RRLWWNTTFD KLFDHHPRQQ GKVKKKGGHR RAAADD---- ---------- --GPQMMLSR RRGRVVVVTN NNNSSLLYYT GRVKKKGGHR REEEPP---- ---------- --GPQMMISR RRGRVVIITN NNNSSLLYYS GSVRRRGGRR RAAAPP---- ---------- --GPQMMVSR RRGRVVWWTN NNNSSLLYYT GSVHHHGGRR RTTTPP---- ---------- --APQMMVSR RRGRVVWWTN NNNSSLLYYT GKVEEEGGKK KTTTPP---- ---------- --YPQMMVSR RRGKVVWWTN NNNSSLLYYT GKVRRRGGSR RAAATTGG-- ---------- AAGPQMMVSR RRGRVVFFTN NNNSSLLYYA GKVQQQGGRR RAAAGG---- ---------- AAGPQMMVSR RRGRVVFFTN NNNSSLLYYA GSVRRRGGRK KAAAAA---- ---------- --GPQMMVSR RRGRVVFFSN NNNSSLLYYS GQIFFFGGVR RGGGGGQQLE -DQELTQPEV VVGPQMMISL LLGKLLAATT TTTSSLLYYD GQIFFFGGVK KGGGGGQQLE -DQELTQPEV VVGPQMMISL LLGKLLVVTT TTTSSLLYYA GQLFFFGGVK KGGGGGQQLE -DQELKQPEV VVGPQMMISL LLGKLLVVTT TTTSSLLYYA GQLFFFGGVK KDDDGGQQLD -DQELDQPEV VVGPQMMISL LLGKLLVVTT TTTSSLLYYA GQLFFFGGVK KGGGGGQQLE -DQELKQPEV VVGPQMMISL LLGKLLIITT TTTSSLLYYA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GQLFFFGGVK KGGGGGQQLE -DEELKQPEV VVGPQMMISL LLGKLLIITT TTTSSLLYYA GQIFFFGGVK KGGGGGQQLE -DQELKQPEV VVGPQMMISL LLGKIIVVTT TTTSSLLYYD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GQIFFFGGLR RGGGGGTTLE -DKDLEQPDI VVGPQMMISL LLGKLLVVTN NNNSSLLYYK GQIFFFGGQR RGGGGGTTLE -DKELEQPDT VVGPQMMISL LLGKIIVVTS SSSSSLLYYI GQLWWWGGQK KGGGSSAAIG -EDGKTQSDE IIGPQMMITL LLGKLLVVTN NNNSSLLFFA GQVWWWGGQK KGGGSSVVVK -DDGETQSDE IIGPQMMISL LLGKLLVVTN NNNSSLLFFA GQIWWWGGQK KGGGSSKKVG -EDGNSQFDQ IIGPQMMISL LLGKLLAATN NNNSSLLFFA GQIWWWGGQK KGGGSSKKVG -EDGNTQFEQ IIGPQMMISL LLGKLLAATN NNNSSLLFFA GQVWWWGGQK KGGGSSVVVT -EDDKEQYSQ VVGPQMMISL LLGKIIVVTN NNNSSLLFFR SQVYYYGGHT TEEESSKKLE -GEK--PIEY VVGPQMMLSL LLGKLLVVTT TTTSSLLYYK SQVFFFGGHS SEEETTKKLE -EDHD-EIPY VVGPQMMLSL LLGKLLVVST TTTSSLLYYK ---------- ---------- ---------- --GPAKKISV VVGKLLVVTN NNNSSFFYYT GQVFFFGGQR RDDDAARRLN -DPELKAPEF LLGPQMMLSL LLGRLLVVSS SSSSSLLFFP GQLFFFGGCS SDDDLLVVVK EDKELKRPPY VVGPQMMLSL LLGKLLVVSS SSSSSLLYYP ---------- ---------- ---------- ---------- ---------- ---------- YEKVVVDRN- ---------- ---------- -----MMVSW WWGKVVFFSS SSSSSLLLLN YEKTTTGAN- ---------- ---------- -----MMVSW WWGQLLYYTS SSSSSLLLLN FFFYYKKMMK LNNN--PSSG GGLEIIDDFF FFE-----RR HHHVRGGGAS SDYYYYP--- FFFYYRRMMK VNNN--PEEG GGLELLEEFF FFR-----RR HHHVRGGGAS TDFFFYP--- FFFYYPPQQL AHGG--PDDG GGLTLLAAYW WWDG----RR HHHIRGGGCS TDFFFYPSSV FFFYYPPEEM ANGG--GNNG GGLELLDDYF FFDG----RR HHHIRGGGCS TDFFFYPSSV FFFYYGGMMM ANGG--ENNG GGLTLLDDFW WWAG----RR HHHIRGGGCS TDFFFYPSSV FFFYYDDMMK LDGG--PNNG GGIEFFDDFF FFKG----RR HHHVRGGGCS SDYYYYP--- FFFYYKKMMK VDNN--PDDG GGMQFFDDFF FFE-----RR HHHIRGGGAS SDYYYFP--- FFFYYRRIIK AEDD--PGGG GGLSLLDDFF FFDG----RR HHHIRGGGSS SDYYYYPSS- FFFYYIIGGV MLVVDDVNNG GGLKLLNNFL LLKEGGGPLL HHHLRGGGCS SDWWW----- FFFYYIIGGV MLIIDDANNG GGLKLLNNFL LLKEGGGPLL HHHLRGGGCS SDWWW----- FFFYYIIGGV MLIIDDVKKG GGLKLLNNFL LLKEGGGPLL HHHLRGGGCS SDWWW----- FFFYYIIGGV MLIIDDVKKG GGLTLLNNFL LLKEGGGPLL HHHLRGGGCS SDWWW----- FFFYYIIGGV MLVVDDVKKG GGLKLLNNFL LLKEGGGPLL HHHLRGGGCS SDWWW----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FFFYYIIGGV MLVVDDVKKG GGLKLLNNFL LLKEGGGPLL HHHLRGGGCS SDWWW----- FFFYYIIGGV MLIIDDVKKG GGLKLLNNFL LLKEGGGPLL HHHIRGGGCT SDWWW----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FFFYYIIGGV MLIIDDEKKG GGLKLLNNFL LLKEGGGPLL HHHLRGGGCS SDWWW----- FFFYYLLGGV MLIIDDKKKG GGLKLLNNFL LLKEGGGPLL HHHIRGGGCT SDWWW----- FFFYYVVGGH ILIIDDEKKG GGLKIINNFF FFAEGGGPLL HHHMRGGGCT SDWWW----- FFFYYVVGGH ILIIDDENNG GGLKIINNFF FFAEGGGPLL HHHMRGGGCT SDWWW----- FFFYYMMGGH IIIIDDEKKG GGLSIINNFF FFDEGGGPLL HHHMRGGGCT SDWWW----- FFFYYMMGGH IIIIDDEKKG GGLTIINNFF FFDEGGGPLL HHHMRGGGCT SDWWW----- FFFYYVVGGH MLIIDDEKKG GGLSIINNFF FFAEGGGPLL HHHMRGGGCT SDWWW----- FFFYYVVGGT MVVVDDESSG GKMEIINNFL LLKIGGGPLL HHHMRGGGCT SDWWW----- FFFYYVVGGT MLIIDDITTG GHMVIINNFL LLKVGGGPLL HHHMRGGGCT SDWWW----- FFFYYVVGGV MLIIDDEKKG GGLTVVNNFL LLKEGGGPLL HHHIRCCCST SDLLL----- FFFYYVVGGT IVLLDDENNG GGMKLLNNFL LLGEGGGPLL HHHMR----- ---------- FFFYYVVGGH IVIIDDVNNG GGISLLNNFL LLNEGGGPLL HHHMRGGGCT SDWWWANDDA ---------- ---------- ---------- ---------- ---------- ---------- -------GGD DAYYAANWWD DGKELLVVFA AAELGGG-RR HHHMRSSSLY SS-------- -------GGD DEFFLLYWWD DGKELLKKFA AAAEGGG-RR HHHMRAAALY AGAAADGNNR ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QQARRVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMMNSKKKAK KKQPPSSEAA TCRRTTTTTG GGLLLLTAAA ARLAAMMQSS RRALLLLLLL gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLTPPGGSPP VRRRRIKAYQ QQEEAAATFF FLSPPPRSEE SSSKGGTTRV PPGGVVEESS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MA AAGGRRRPTT TRPPPPHPNN PPPLAASSPH PPRRPPLLRL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------I VKKDDDDPPT TFFYPPKMKK ---------- ---------- ---------- ---------M AKKDDDDPPT TFFYPPRMRR ---------- ---------- ---------- ---------- MRRDDDDPPT TFFHAPEMQQ ---------- ---------- ---------- ---------- MRRDDDDPPT TFFHAPKMEE ---------- ---------- ---------- ---------- MRRDDDDPPT TFFYPAKMEE ---------- ---------- ---------- ---------M AKKDDDDPPS SFFYPPRAKK ---------- ---------- ---------- ---------M VRRDDDDPPT TFFYPPRVKK ---------- ---------- ---------- ---------M ARRDDDDPPT TFFYPPKMQQ ---------- ---------- ---------- -------AAC T--GGGGPPG GYYPTLEK-- ---------- ---------- ---------- ---------- ---------- -------M-- VAAVVSSQQA AAVVHHLLPP KKGGAAVVPP AAGGGLGSSC G--GGGGPPG GYYPSLEK-- ---------- ---------- ---------- ---------- ---------- -------K-- ---------- ---------- ---------- -------AAC G--GGGGPPG GYYSTLEK-- ---------- --------AA AAGGAATTVV AAPPPMIAAC G--GGGGPPG GYYSTLEK-- ---------- ---------- ---------- -------AAC G--GGGGPPG GYYSTLEK-- ---------- ---------- ---------- -------AAC G--GGGGPPG GYYSTLEK-- ---------- ----MMLLGG EEGGHHAAFF LLGGGQQAAC G--GGGGPPG GYYPTQEK-- ---------- ----KKSSQQ LLFFDDTTLL HHYYYCVPPC G--GGGGPPG GYYSTLEK-- ---------- ---------- ---------- -------AAC G--GGGGPPG GYYSTLEK-- RPPIIVVPPP PRLLPPAARR LLLLQQIIAA AAVVVEAGGC CAAGGGGPPG GYYATLEEKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMC G--GGGGPPG GYYKSLDK-- ---------- ---------- --------VV LLHHHGNSSN GKKGGGGPPG GYYASIES-- ---------- ---------- --------VV LLHHHASNNQ GKKGGGGPPG GYYASLES-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R MVVGGGGPPG GYYATLAS-- ---------- ---------- ---------- ------AGGC CAAGGGGPPG GYYATLEEKK ---------- ---------- ---------- ------SGGC H--GGGGPPG GYYASADK-- ---------- ---------- ---------- ------PPPC H--GGGGPPG GYYASADK-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------E SKKGGGGPPG GYYATLDRNN ---------- ---------- ---------- ---------- ---------- -------RSS ---------- ---------- ---------- ---------- ---MMMMPPG GLLIT-DISS ---------- ------MMKK EEGG------ --AAALGAAL PAAAAAADDE ETTCQPYKII ---------- ------MMKK IISSGGSSAA LLAAALGAAA PVVAAAADDE ETTCAPYKII KAAPELAAYY YVAACCCLLY YTGIIRDAAV VVNPPKSSSE TYYYSVELLP PYIIDDGWNN RAAPEIAAYY YVAAAAALLY YVGVVADAAV VVDPPKSSSP TYYYGLDLLP PYIIDDGWNN QAAPEFAAYY YTLLLLLLLS SPS--RDAAV VVKPPGSSSS TYYYGVTMMP PNTTDDGWNN EAAPEFAAYY YTLLLLLLLS SPS--KDAAV VVKPPGSSSP TYYYGVTMMP PNKKDDGWNN EGGPELAAFF FTLLMMMLLS SPS--KDAAV VVDPPTSSSE KFFFGLIMMP PNKKDDGWNN KAAPEIAAYY YVAAMMMFFD DPK--QDAAV VVDPPASSSP RYYYAVAMMP PHAADDGWNN KAAPELAAYY YVVVRRRLLN NPNGGKDCCV VVDSSQSSSS TFFFGTDMMP PYTTGGGWNN QAAPELGGYY YVAALLLLLD DPE--RDGGV VLDPPDSSSG TYYYAVEMMP PNAADDGWNN -GGPEIVVYY YLPPCCCIIY YRGTTADAAT TVDPPKSSSP QYYYSLPMMP PYLLDDGWNN -GGPEIVVYY YLPPCCCIIY YRGIIADAAT TVDPPKSSSP HYYYSLPMMP PHLLDDGWNN -GGPEIVVYY YLPPCCCIIY YGGIIADAAT TIDPPKSSSP QYYYCLPMMP PNLLDDGWNN -GGPEIIIYY YLPPCCCIIY YRGIIADAAT TVDPPKSSSP QYYYCLPMMP PHLLDDGWNN -GGPEIVVYY YLPPCCCIIY YRGTTADAAT TVDPPKSSSP QYYYCLPMMP PNLLDDGWNN -GGPEIVVYY YLPPCCCIIY YRGTTADAAT TVDPPKSSSP QYYYC----- ---------- -GG------- ---------- ---TTADAAT TVDPPKSSSP QYYYCLPMMP PNLLDDGWNN -GGPEIVVYY YLPPCCCIIY YRGTTADAAT TVDPPKSSSP QYYYCLPMMP PNLLDDGWNN -GGPEIVVYY YLPPCCCIIY YRGTTADAAT TVDPPKSSSP QYYYSLPMMP PYLLDDGWNN -GGPEIVVYY YLPPCCCIIY YRGTTADAAT TVDPPKSSSP QYYYCLPMMP PNLLDDGWNN -GGPEIVVYY YLPPCCCIIY YRGTTADAAT TVDPPKSSSP QYYYCLPMMP PNLLDDGWNN KGGPELVVYY YVTTCCCVVY YNGIIKDAAT TLDPPSSSSP TYYYSLPVVI IHIIDDGWNN ---------- ---------- ---------- ---------- -------MMP PNTTDDGWNN -GGPEIVVYY YLPPCCCIIY YRGIIKDAAT TVDPPKSSSP SYYYSLPMMP PNVVDDGWNN -GGPELIIYY YVTTAAAVVY YAGIIKDAAT TVDPPSSSSP TYYYSLPVVP PYVVDDGWNN -GGPELIIYY YVTTAAAVVY YAGIIKDAAT TLDPPNSSSP TYYYSLPVVP PYVVDDGWNN ---------- ---------- ---------- ---------- -------MMP PFVVDDGWNN -GGPELIIYY YVTTAAAVVY YTGIIKDAAT TVDPPSSSSP SYYYSLPMMP PFVVDDGWNN KGGPELLLYY YVTTCCCVVY YNGIIKDGGT TVDPPNSSSP TYYYSLPVVT THVVDDGWNN -GGPEVLLFF FVTTAAAPP- --AAAGDFFT TVNPPESSSD TFFFCVDVVP PHIIDDGWNN -GGPEVLLFF FVTTAAAPP- --ARRGDFFT TVNPPESSSE TFFFCVDVVP PNIIDDGWNN ---------- ---------- ---------- ---------- ---------- ---------- NGGPELLLYY YVVVCCCVVQ QPDEEHDAAT TVDPPASSSP TYYYCTYTTN NSKKNNGWNN SGGPELLLYY YTVVTTTVVQ QPDEEHDSST TVDPPESSSP TYYYCTFTTN NRKKDDGWNN SLLDRLYYFF FSNNWWWLLH HGRQQDTKKN NMVGGQVVVF LGGGGGPVVK KVLLDDQPTT ITTGEFVVYY YVWWTTTLLG GVMGGEDVVT TLRPPGSSSA TRRRGVSVVG GG--NNGFSS ITTGEYVVYY YVWWTTTLLG GAVGGEDVVT TANPPKSSSP QYYYGLSVVG GG--NNDFTT ACCNGG--KP IRRRFLLIII VVGLRRRSSS YIIIDTTTKE EEKIIIKVII IEPPPPEEEE ACCNAA--KP LRRRYLLIII VVALRRRSSS YIIIDTTTKR RRAVVAKIVV VEPPPPEEEE SSSLTTGGHA LRRRFLLIII IIGLRRRSSS YVVVDTTTKQ QQRIIHKIII IEPPPPDDDD ASSLAAGGHA IRRRYLLIII IIGLRRRSSS YIIIDTTTKK KKKIIHKIII IEPPPPEEEE ASSLTTGGHA LRRRYLLIII IIGIRRRSSS YIIIDVVVKK KKKIIHKIII IEPPPPEEEE CCCNAAPPHP MRRRYLLVVV VVGLRRRSSS YIIIDTTTKK KKFLLAKVII IEPPPPEEEE MCCNAAPPHP VRRRYLLVVV VVDIRRRSSS TIIIDTTTKQ QQKVVVKVII IDPPPPNNNN ACCYAAPPHP VRRRYLLIII VVGIRRRSSS HIIIDTTTKE EERIIVKVII IEPPPPEEEE C---FFGGDS KNNNKLLIII LLGLMMMSSS YVVVDVVVGA AAKLLHKVII IEAAAASSSS C---FFGGDS KDDDKLLIII LLSIIIISSS YVVVDVVVGA AAKLLHKVII IEPPPPNNNN C---FFGGDS KTTTKLLMMM LLCLMMMSSS YVVVDVVVGA AAKLLHKVII IEAAAAEEEE C---YYGGDI KTTTKLLVVV LLALIIISSS YVVVDVVVGA AAKLLHKVII IEPPPPKKKK C---FFGGDS KTTTKLLVVV LLSLIIISSS YVVVDVVVGA AAKLLHKVII IEPPPPEEEE ---------- ---------- ---------- ---------- ---------- --PPPPKKKK C---FFGGDS KTTTKLLVVV LLSLIIISSS YVVVDVVVGA AAKLLHKVII IEPPPPKKKK C---FFGGDS KTTTKLLVVV LLSLIIISSS YVVVDVVVGA AAKLLHKVII IEPPPPKKKK C---FFGGDS KNNNKLLVVV LLSFIIISSS YVVVDVVVGA AAKLLHKVII IEAAAAKKKK C---FFGGDS KTTTKLLVVV LLSL------ ---------- ---------- ---------- C---FFGGDS KTTTKLLVVV LLSLIIISSS YVVVDVVVGA AAKLLHKVII IEPPPPKKKK C---HHGGDP ARRRFLLIII LLSLLLLSSG YVVVDTTTAT TTSLLHKVVV VESSSSEEEE C---YYGGDA KNNNKLLIII LLCLIIISSS YVVVDVVVGA AARIIHKTVV VEPPPPYYYY C---YYGGDS KNNNKLLIII LLCLIIISSS YVVVDVVVGA AARIIHKTVV VEPPPPYYYY C---HHGGDP ARRRFLLIII AASLVVVSSG YVVVDTTTKS SSSLLHKVVV VDPPPPAAAA C---HHGGDP ARRRFLLIII VVGIVVVSSG YVVVDTTTKA AASLLHKVVV VEPPPPEEEE C---HHGGDA ARRRYLLVVV LLSLIIISSG YAAADTTTKA AASLLYKYVV VDPPPPKKKK C---HHGGDA VRRRYLLVVV LLSLIIISSG YAAADTTTKA AASLLYKYVV VDPPPPKKKK C---HHGGDP ARRRFLLIII LLSLLLLSSG YVVVDTTTLA AAALLHKVVV VEAAAAEEEE C---HHDDKP ESSSHLLIII VVCLNNNSSD YIIINVVVEK KKYLLEHTII IEPPPPSSSS C---HHDDKP ESSSHLLIII VVCLNNNSSD YVVVNVVVEE EEYLLQHTII IEPPPPSSSS ---------- -----MMVVV PPKLSSSSSG GKKKFVVVG- ---------- ---------- CFF-GGGGKE PDDDRLLVVV LLCLNNNSSD FVVVDTTTGA AAKLLAKVII IEGGGG---- CYYESSSSKT PDDDRLLVVV LLSLNNNSSD YIIIDVVVVK KKEIIVKTII IDGGGG---- K-----GGKR QPPPQMMLLL QQSLDDDGGK YVVVTSSSLD DDQFFYP--- ---------- ---------- -RRRFFFWWW TTGLDDDTTN FIIIDVVVHN NNKLLHKTII IDTTTT---- ---------- -RRRYLLWWW AAGLDDDTTS FVVVDVVVHR RRVLLSKTII ITDDDD---- VVVVKKKKVV SSSSSYYSPP PIISG---GG --EGPGILLL LLDDFPLLLG KWWWEEEIRG AAAAVGGGRR TTTTTYYTPP PIISG---GG RREGPGIFLL LLDDFPIIIG RWWWEEEVRG IIIILAAAKK TTTTTYYSPP PIVSGGGKGG TTDGAGIFMM MMDDFVLLLG RWWWEEEIRG VVVVFKKKKK TTTTTYYSPP PIVSGGGKGG TTNGPGVFMM MMDDFVLLLG RWWWEEEIRG VVVVFAAAKK TTTTTYYSPP PIVSGGGEGG TTDGPGIFLL LLDDFILLLG RYYYEEEMRG LLLLAEEERR TTTTTYYSPP PIVTG---GG --KGPGIALL LLDDFPLLLG RWWWEEEVRG LLLLAEEERR TTTTTYYAPP PIISG---GG --EGPGIFLL LLDDLVLLLG RWWWEEEIRG LLLLHRRRRR TTTTTYYSPP PVVSG---GG --DGPGVFMM MMDDFPLLLG RWWWEEEVRG IIIIQAAAKK CCCCCVVSAA AEMVL---QQ GGNGKSFVLL LLDDFVKKKG TWWWEEEKGG IIIIHAAAKK CCCCCLLGAA AEMIL---QQ GGNGKGFVLL LLDDFVKKKG TWWWEEEKGG IIIIHAAAKK CCCCCLLGAA AEMIL---KK GGNGKGFVLL LLDDFVKKKG TWWWEEEQGG IIIIHTTTKK CCCCCLLGPP PEMVL---EE GGNGKGFVLL LLDDFVKKKG TWWWEEEQGG IIIIHAAAKK CCCCCLLAAA AEMIL---KK GGNGKGFVLL LLDDFVKKKG TWWWEEERGG IIIIHAAAKK CCCCCLLAAA AEMIL---KK GGNGKGFVLL LLDDFVKKKG TWWWEEERGG IIIIHAAAKK CCCCCLLAAA AEMIL---KK GGNGKGFVLL LLDDFVKKKG TWWWEEERGG IIIIHAAAKK CCCCCLLAAA AEMIL---KK GGNGKGFVLL LLDDFVKKKG TWWWEEERGG IIIIHEEEKK CCCCCLLGPP PEMIL---KK GGNGKGFVLL LLDDFVKKKG TWWWEEERGG ---------- ---------- ---------- ---------- ---------- ---------- IIIIHAAAKK CCCCCLLAAA AEMIL---KK GGNGKGSLLL LLLLLCSSSG ---------- IIIIAEEENN IIIIILLGAA ADMIL---EE GGNAANGFLL LLLLFVKKKG RGGGSSSNLF VVVVFWWWKK CCCCCLLAGG GEMII---YY GGNGKGFVLL LLDDFVKKKG NWWWEEEAGE VVVVFWWWKK CCCCCLLAGG GEMIL---CC GGNGKGFVLL LLDDFVKKKG NWWWEEEVGE IIIIIQQQKK TTTTTLLAAA AEMIL---DD GGNAENGFLL LLLLFVKKKG RWWWEEEKGH IIIISTTTKK TTTTTLLAAA AEMII---DD GGNAENGFLL LLLLFVKKKG RWWWEEEKGH IIIIAEEEKK TTTTTLLAAA AELVL---EE GGNAKNGFLL LLLLFIKKKN RWWWEEEKGH IIIIADDDKK TTTTTLLATT TELVL---EE GGNAKNGLLL LLLLFIKKKN RWWWEEEKDI IIIIAEEEKK TTTTTLLGAA AEMIL---EE GGNAANGFLL LLLLFVKKKG RWWWEEEKGH LLLLHSSSLL NNNNNLLSAA ANMIL---NN GGTPSNFLLL LLDDFPKKKG TWWWPPPAEK LLLLHAAALL NNNNNLLSAA ANMIL---DD GGSPSNFLLL LLDDFPKKKG TWWWPPPAGK ---------- ---------- ---------- ---------- ---------- ---------- VVVVLKKKGG AAAAACCTPP PNMIM---EE GGNAK-DFEE EEFFFLVVVG TWWWSSSRDR VVVVLKKKSS HHHHHVVTAA ANMIM---EE GGYAK-DFLL LLFFFCIIIG TWWWTTTKDK LLLLIKKKFF LLLLLLLAPP PAKQV---LL SSVPVNGITT TTSSNLSSSA KGGGEEEAQF VVVVKDDDSS GGGGGVVVPP PMITS---DD HHGGRALVYY YYNNEVAAAT YWWWMMMPAD VVVVEKKKSS GGGGGVVVPP PMITS---DD HHGGRALVYY YYTTEVAAAT HWWWIIIPDG DDQQ------ ---------Y DDFWWWWNLP PVLLLLSEAP NNN-TEGG-L KKLEEHK--R PPQQ------ ---------Y DDFWWWWNLP PVMMMMSETP RRR-CEGG-F SSLEECKGGA PPQQ------ ---------Y DDFWWWWNLP PYMMMMSEAP PPP-QEGG-I VVPEEDLNNK PPQQ------ ---------Y DDFWWWWNLP PYMMMMSEAP PPP-QEGG-I VVPEEDLNNK EEQQ------ ---------Y DDFWWWWNLP PYMMMMSEGP PPP-QEGG-I VVPEEDLNNK PPQQ------ ---------Y DDGWWWWHLG GTLLLLSEGP DDD-MEGG-L VVPDDILAAR DDQQ------ ---------Y DDFWWWWHLG GTLLLLSEGP RRR-MEGG-V LLGDDELGGK PPQQ------ ---------Y DDFWWWWHLG GTMMMMSEGP NNN-MEGG-L DDPQQILKKG AASS------ ---------Y DDFWWWYQPR RVMMMMTEAP NNN-VKGGFN PPAHHVAGGL EEAA------ ---------Y DDFWWWYQPR RIMMMMTEAP NNN-VKGGFN PPAHHVAGGL AAAA------ ---------Y DDFWWWYQPR RVMMMMTEAP NNN-VRGGFN PPADDVAGGL AAAA------ ---------Y DDFWWWYQPR RVMMMMTEAP NNN-VRGGFN PPADDVAGGL AAAA------ ---------Y DDFWWWYQPR RVMMMMTEAP NNN-VRGGFN PPADDVAGGL AAAA------ ---------Y DDFWWWYQPR RVMMMMTEAP NNN-VRGGFN PPADDVAGGL AAAA------ ---------Y DDFWWWYQPR RVMMMMTEAP NNN-VRGGFN PPADDVAGGL AAAA------ ---------Y DDFWWWYQPR RVMMMMTEAP NNN-VRGGFN PPADDVAGGL SSAA------ ---------Y DDFWWWYQPR RVMMMMTEAP NNN-VQGGFN PPADDVAGGL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------AIAS NNN-LLGGSR DDYPPAASSR PPII------ ---------R TTHLLLYENA ALFFFFWICS LLL-FTGGAE LLMCCLASSG AAAA------ ---------Y DDFWWWYQPR RVMMMMTEGP KKK-AAGGFK MMEEEVAGGM SSAA------ ---------Y DDFWWWYQPR RVMMMMTEGP KKK-AAGGFK MMEDDVAGGH SSPP------ ---------Y DDFWWWYQPR RTMMMMTSGP TTT-ATGGFD LLQHHVDGGL SSPP------ ---------Y DDFWWWYQPR RTMMMMTSGP KKK-ALGGFN LLQHHVDGGL SSPP------ ---------Y DDFWWWYQPR RTMMMMTSGP KKK-ASGGFD LLQHHVDGGL SSPP------ ---------Y HHFWWWYQPR RTMMMMTSGP KKK-ASGGFN LLQHHVDGGL SSPP------ ---------Y DDYWWWYQPR RTMMMMSSGP AAA-ARGGFD LLQHHVDGGL TTVV------ ---------Y DDFWWWYQPR RVMMMMTEGP NNN-HKGGFN PPAHHVEGGL VVVV------ ---------Y DDFWWWYQPR RIMMMMTEGP NNN-HKGGFN PPAHHVEGGL ---------- ---------- ---------- ------ILGP VVV-TCDDEE LLKCCQEPPL KKAA------ ---------Y DDYWWWYQPH HVMMMMSEGP KKK-LRGGYH PPTDDCDTTQ KKAA------ ---------Y DDFWWWYQPY YVMMMMSEGP NNN-KRGGWK NNVDDLDSSQ EEEE------ ---------L SSNHHHNNG- -KSSSSDRDP III-MFSSSE SSFLLKTPPL DDMMGAVVAA VGGAVVVAGY DDIRRRALIR RVMMMMSSTW SSSYMDGGQM LLQDDAAKKR DDLLGAIIKK TGGKYYYAGY DDVRRRALPR RLLLLLSSTW NNNYMDGGKM LLADDPAKKH YYGGNRRRHF FWWWDDRRKI ISLGEEEENN RM-----RHH DPTTTLLLMM IIMVVSSKDS YYGGNKKKHV VWWWDDRRRL LALGQQQQHH RM-----RHH DPTTTLLLMM VVVVLNNKDS YYGGHRRRHF FWWWDDRRRV VTLGAAAAHH QM-----RHH DPVVVEEEYY VVVVVDDTNE YYGGHRRRHF FWWWDDRRRV VTLGAAAAHH QM-----RHH DPVVVEEEYY VVVVVDDTNE YYGGHKKKHF FWWWKKRRKV VTLGAAAAHH QM-----RHH DPSSSDDDYY CCVVVDDTNQ YYGGRRRRHF FWWWDDRRRL LEFGDDDDHH QL-----RHH DPTTTAAAYY VVCVISSKDS YYGGHRRRHV VWWWDDRRRL LTLGAAAAYY QM-----RHH DPTTTAAAYY MMCVVSSKDS YYGGRRRRHI IWWWDDRRRL LAVGEEEEHH QM-----RHH DPAAATTTYY VVVVVSSEDS YYGGSRRRFV VWWWDDHHEI ITMT----DD GL----LRHH DPSSSTTTQQ VVCALSSNIR YYGGSHHHHV VWWWDDHHEI ITMK----DD GL----LRHH DPDDDTTTQQ VVCALSSNIR YYGGSHHHHV VWWWDDHHEI ITLQ----DD GL----LRHH NPDDDAAAQQ VVCALSSTIR YYGGSHHHYV VWWWDDRREV VTLQ----DD GL----LRHH NPDDDAAAQQ VVCALSSTIR YYGGSHHHYV VWWWDDHHEV VTLK----DD GL----LRHH NPDDDAAAQQ VVCALSSTIR YYGGSHHHYV VWWWDDHHEV VTLK----DD GL----LRHH NPDDDAAAQQ VVCALSSTIR YYGGSHHHYV VWWWDDHHEV VTLK----DD GL----LRHH NPDDDAAAQQ VVCALSSTIR YYGGSHHHYV VWWWDDHHEV VTLK----DD GL----LRHH NPDDDAAAQQ VVCALSSTIR YYGGKHHHHV VWWWDDHHEV VTMP----DD GH----LRHH DPAAASSSQQ VVCALSSTIR ---------- ---------- ---------- ---------- ---------- ---------- VVAAGIII-- ---------- ---------- ---------- ---------- ---------- VVHHVIIICL LDDDNNRRVD DSLQ----DD QANNNILRHH WKNNNNNNQQ DDVEVSSSGG YYGGHSSSNV VWWWDDHHRI ITLGEEEEDD GL----LRHH DPDDDAAAQQ VVCALSSTVR YYGGHSSSNV VWWWDDHHRV VTLGKKKKDD GL----LRHH NPDDDDDDQQ VVCALSSSIR YYGGRHHHTC CIIIQQGGER RTLGNNNNTT GL----LRHH DPAAADDDTT VVSALSSNMR YYGGRHHHHV VYYYSSGGEK KTLGDDDDKK GL----LRHH DPAAADDDTT VVSALTTNMR YYGGSHHHHV VYYYSSGGEK KLLGEEEETT GL----LRHH DPSSSDDDTT VVSALSSNMR YYGGSHHHHV VYYYSSGGEK KLLGPPPPTT GL----LRHH DPSSSDDDTT VVSALSSNMR YYGGRHHHHV VYYYDDGGEK KTLGSSSSTT GL----LRHH DPSSSDDDTT VVCALTTNMR YYGGNSSSHI IFFFEEKKKL LTLPQQQQLL GA----LRHH EPTTTEEEHH VVCALGGGIR YYGGNSSSHI IFFFEEKKKL LTLPMMMMRR GA----LRHH EPTTTEEEHH VVCALGGAIR VVIIKCCCRV VYYY------ ---------- ---------- ---------- ---------- YYGGCRRRNF FYYYRRRREF FTLGDDDDDD GL----LRHH NPRRRNNNQQ VVCAFXXXXX YYGGCRRRNF FYYYKKQQTY YTLGSSSSDD GI----LRHH NPKKKAAAEE VVCALNNKVH KKPPQHHHAE EVVVLL---- ---------- ---------- ---------- ---------- FFGGNTTTVQ QWWWDDRRQK KVVPGGGGPP ------LRWW GSNNNNNNYY SSTALTTQLL FFGGNTTTVT TWWWDDKKQK KVVPGGGGPP ------LRWW GEAAANNNYY TTTALTTQLL SSSSSIIIIW WWFYEKEKVI PPAALEEEEN EELKPPFAAV PPLVDSLKYL SSSGGGRQYI SSSSSIIIIW WWFYEKERVI EEAAFEEEEP PPLKDDFMMV PPLVDSLRYV SSSGGGRQYI EESSSIIIIW WWWREKKKTA PPAAATTTTE PPLQGGFAAV PPLVDSLRYV SSSGGGRQYV EESSSIIIIW WWWREKEKTA PPPPAPPPPK PPLQGGFAAV PPLVDSMRYV SSSGGGRQYV QQAAAIIIIW WWWQDTKKTI DDPPADDDDD DDLKGGFAAC PPLVDSLKYV AAAGGGHQYV SSSSSIIIIW WWYRDKRKVI PPAAADDDDQ PPLKGGFAAV PPLVDSMRYV SSSGGGLQYV SSSSSIIIIW WWYRDSKKVI PPAAASSSSQ PPLKPPFAAV PPLVDSVRYV SSSGGGHQYV SSSSSVVVVW WWHRQSRKVI PPAAAEEEEQ PPLKDDFAAV PPLVDSLRYV SSSGGGRQYV RRYYYKKKKE EEG------T VVEEIQQQQS VVGWMMLEEM PGLIDSLRYF SSSLGGRQYI RRYYYKKKKG GGG------T VVEEIQQQQS VVGWMMLEEM PGLIDSLRYF SSSLGGRQYI RRYYYKKKKG GGG------T VVEEIQQQQP VVGWMMLEEM PGLIDSLRYF SSSLGGRQYI RRFFFKKKKD DDG------T AAQQIQQQQP VVGWMMLEEM PGLIDSLHYF SSSLGGRQYV RRYYYKKKKG GGG------T VVEEIQQQQP VVGWLLLEEM PGLIDSLRYF SSSLGGRQYI RRYYYKKKKG GGG------T VVEEIQQQQP VVGWLLLEEM PGLIDSLRYF SSSLGGRQYI RRYYYKKKKG GGG------T VVEEIQQQQP VVGWLLLEEM PGLI------ ---------- RRYYYKKKKG GGG------T VVEEIQQQQP VVGWLLLEEM PGLIDSLRYF SSSLGGRQYI RRYYYKKKKG GGG------T VVEEIEEEEP VVGWMMLEEM PGLIDSLRYF NNNLGGRQYI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGSSSDDDDA AAY------A LLKKLDDDDY VVKFGGVSSL SNEFPFFLIF LLL------- RRYYYKKKKD DDG------K AAEEIKKKKS VVGWAALEEM PGLIDSLRYF SSSLGGRQYI RRYYYKKKKD DDG------K AAEEIQQQQS VVGWPPMEEM PGLIDSLRYF SSSLGGRQYI RRFFFKKKKD DDG------S HHEEIPPPPP VVNWIILEEM PGLIDSLRYF VVVLGGRQYI RRFFFKKKKD DDG------S HHEEISSSSP VVNWFFLEEM PGLIDSLRYF VVVLGGRQYI RRFFFKKKKD DDD------T YYEEISSSSP VVNWIILEEM PGLIDSLRYF VVVLGGRQYI RRFFFKKKKD DDE------T HHEEISSSSP VVNWIILEEM PGLIDSLRYF VVVLGGRQYI RRFFFKKKKD DDG------S HHEEISSSSP VVNWIILEEM PGLIDSLRYL VVVLGGRQYI RRHHHPPPPE EENS---T-T AATTAFFFFS VVGWAALEEM PALIDSMRYV SSSLGGRQYI RRHHHPPPPK KKNP---K-V AASSATTTTS VVNWAALDDM PALIDSMRYV SSSLGGRQYI ---------- ---------- ---------- ---------- ---------- ---------- XXXXX----- ---------- ---------- GGNGEEIMMM GGMMDSLRYF SSSRGGRQYI HHKKKKKKKD DDSD---EFE KKVVIPPPPL TTSGVVADDM GGMIDSLRYV NNNRGGRQYI ---------- ---------- ---------- ---------- ---------- ---------- LLYYYEEEEA AAG------- -----EEEEA VVDIGGNAAD IPLPDAAQWI NNNMGGRLFI LLYYYEEEEE EEG------- -----EEEEA VVDIGGEAAK VPLPDSNSWV NNNMGGRLFI SNPFPPLLLL TGKKKLLLGG GGIHHRRDHH P--------- ---------- AGHKLTGAPQ TNPHPPLLLL AGRKKIIIGG GGLHHRRPHH P--------- ---------- SGAEATGAPQ SDPHPPLLLL AGSRRIIIGG GGIRRRRPHH P--------- ---------- NGRTFAGGPQ SDPRPPLLLL AGSHHIIIGG GGIRRRRPHH P--------- ---------- NGKAFAAGPQ SDPMPPLLLL TGKEEIIIGG GGIKKKKPHH P--------- ---------- NGKTFGYGPQ SDPFPPLLLL TGKRRIIIGG GGISSRRTHH PG-------- ---------- KNGALNGGPQ SDPFPPLLLL TGKQQIIIGG GGIRRRRGHH P--------- ---------- TSAELNGGPQ SDPFPPHHHH TGSRRLLLGG GGIRRKKAHH P--------- ---------- ASGPLNGGPQ SNPQPPLLLL TGQFFLLLGG GGSVVRRGSS VQVLEELQQQ PPPEPPLLVV KGKRIPGGPQ SNPKPPLLLL TGQFFLLLGG GGSVVKKGSS VQVLEELQQQ PPPEPPLLVV KGKRVPGGPQ SDPQPPLLLL TGQFFLLLGG GGSVVKKGPP VQVLEELQQQ PPPEPPLLVV KGKKVPGGPQ SDPQPPLLLL TGQFFLLLGG GGSVVKKGPP VQVLDDLQQQ PPPEPPLLVV KGKQVAGGPQ SDPQPPLLLL TGQFFLLLGG GGSVVKKGPP VQVLEELQQQ PPPEPPLLVV KGKRVAGGPQ SDPQPPLLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SDPQPPLLLL TGQFFLLLGG GGSVVKKGPP VQVLEELQQQ PPPEPPLLVV KGKRVAGGPQ SDPKPPLLLL VGQFFLLLGG GGSVVKKGPP VQVLEELQQQ PPPEPPLLVV KGKRVPGGPQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TDPRPPLLLL VGQFFLLLGG GGSLLRRGPP VTVLEELQQQ PPPDPPVVII KGKKVPGGPQ TDTRPPLLLL VGQFFLLLGG GGSQQRRGPP VTVLEELQQQ PPPDPPVVTT KGKIIPGGPQ EDLKPPLLLL TGQWWVVVGG GGLQQKKSPP VAAIGGKQQQ SSSDVVPPEE QGQKLRGGPQ EDVKPPLLLL TGQWWAAAGG GGLQQKKSPP VVAVKKEQQQ SSSDVVPPEE QGKKLRGGPQ EDPKPPLLLL TGQWWVVVGG GGLQQKKSPP VKAVGGNQQQ FFFDVVPPQQ KGKSLRGGPQ EDPKPPLLLL TGQWWVVVGG GGLQQKKSPP VKAVGGNQQQ FFFEVVPPQQ KGKSLRGGPQ EDPAPPLLLL AGQWWAAAGG GGLQQKKSEE VVYVTTKQQQ YYYSVVPPQQ KGHRLRGGPQ SDPLVVLLLL NSQYYIIIGG GGSHHTTSNN VKVLEE-PPP IIIEAALLYY KGRKIEGGPQ SDPKPPLLLL NSQFFIIIGG GGSHHSSTTT VKVLEEDEEE IIIPAALLYY KGRQIEGGPQ ---------- ---------- ---------- ---------- ---------- ------GGPA SDRAPPLLLL TGQFFLLLGG GGAQQRRAPP RRVLNNLAAA PPPEPPVVFF KGRRLLGGPQ TDPEPPLLLL TGQFFLLLGG GGACCSSLPP NVIVKKLRRR PPPPAARRYY KGRRLEGGPQ ---------- ---------- ---------- ---------- ---------- ---------- SDPHPPQQQQ IYEVVIIIDD RRQNN----- ---------- ---------- ---------- SDPHPPQQQQ VYETTIIIGG AAQNN----- ---------- ---------- ---------- EISDGRRTTT YYWDFYYYYE ELKVVLLN-- --SEFG---- --RRRSSSQV VRSGGGDSYC SVSDGRRTTT YYWNFYYYY- -LRAAVVN-- --EEFG---- --RRRAAAQV VRWGGGDTFC EISDGRRTTT YYWDFYYYYD DVPVVAAG-- --DDWPGGG- --RRRAAAQI IREGGGDTFC EISDGRRTTT YYWDFYYYYD DVPVVAAG-- --NDFPGGG- --RRRAAAQI IREGGGDTFC EISDGKKTTT YYWDFYYYYG GRGVVAAG-- --NDWPGGG- --RRRSSSQI IREGGGDTFC EISDGRRTTT YYVDFYYYYE EIDVVLLG-- --NKFPGGG- --RRRPPPQV VRQGGGDSYC EISDGRRTTT YYWDFYYYYD DIKVVVVN-- --DNFG---- --RRRVVVQI IRQGGGDSYC EVSDGRRSSS YYWDFYYYYV VIRAAAAD-- --GGFGGGG- --RRRPPPQI IREGGGDSYC QLSDGKKTTT YYWDFYYYYP PLISSMMVDD DDNNLGEEEP LGLLLAAAEL LRPGGGDSWI QLSDGKKTTT YYWDFYYYYP PLISSMMIDD DDNNLGEEEP LGLLLAAAEL LRPGGGDSWI QLSDGKKTTT YYWDFYYYYP PLISSMMIDD DDKNLGEEEP LGLLLAAAEL LRPGGGDSWL QLSDGKKTTT YYWDFYYYYP PLISSMMIDD DDKNLGEEEP LGLLLAAAEL LRPGGGDSWL QLSDGKKTTT YYWDFYYYYP PLISSMMVDD DDKNLGEEEP LGLLLAAAEL LRPGGGDSWI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QLSDGKKTTT YYWDFYYYYP PLISSMMVDD DDKNLGEEEP LGLLLAAAEL LRPGGGDSWI QLSDGKKTTT YYWDFYYYYP PLISSMMIDD DDKNLGEEEP LGLLLAAAEI IRPGGGDSWL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QLSDGKKTTT YYWDFYYYYP PMISSMMIDD DDKNLGEEEP GGLLLAAAEL LRPGGGDSWV QLSDGKKTTT YYWDFYYYYP PLLAAMMIDD DDKNLGEEEP DGLLLAAAEI IRPGGGDSWI QLTDGKKTTT FFWDFYYYYP PLVSSIIIDD DDKNFGEEEP DGLLLAAAEM MRPGGGDSWI QLSDGKKTTT FFWDFYYYYP PLVSSIIIDD DDNNFGEEEP DGLLLAAAEM MRPGGGDSWI QLSDGKKTTT FFWDFYYYYP PLMSSIIIDD DDKNFGEEEP EGLLLAAAEM MRPGGGDSWI QLSDGKKTTT FFWVFYYYYP PIMSSIIIDD DDKDFGEEEP DGLLLAAAEM MRPGGGDSWI QLSDGKKTTT FFWDFYYYYQ QLVSSMMIDD DDKNFGEEEP EGLLLAAAEM MRPGGGDSWI QLSDGKKTTT YYWDFYYYYP PHVAAMMVND DDSDLGIIIE GGLLLAAAEM MRPGGGDSWI QLSDGKKSSS YYWDFYYYYP PNVAAMMIDD DDTNLGVVVP GGLLLAAAEM MRPGGGDSWI QLSDGKKTTT YYWDFYYYYP PVVSSMMIDD DDKNLGEEEP NGLLLAAADI IRPCGGDSLA QLSDGRRSSS FFWDFYYYYP PMVGGIILDD DDNNLGEEEP YGLLLPPPEM MR-------- QLSDGKKSSS YYWDFYYYYP PMVGGIIIDD DDNDLAEEEP YGLLLPPPEM MRPGGGDSWL ---------- ---------- ---------- ---------- ---------- ---------- SQSDGKKSSS LLWD------ ---KKDDYLA AAWDAYLLLG LGRRRAAAIM MRGSSSAS-- SSSDGQQTTT LLWD------ ---KKDDFLL LLWQAYEEEK LGRRRPPPQM MRGARRAAAG Y------ Y------ YSK---- YS----- YS----- Y------ F------ YS----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AD----- ------- ------- DNLQARR 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNSKKAKKQQ SSEAACRTAV TGGGTTLGGG AMQQLLTLLS LLLPPGGSPR RIKAAYYEEA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- -----MMGGR gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAAFSSSAAA IQAASSPSSS KRKRRSGLLV VVEIISSAAA AQVVSSAVWW WPGKHHHVLI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -ARAEEETLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------G GGEEPPPAQP ---------- ---------- ---------- ---------- --------LN NQCLGGGTNT ---------- ---------- ---------- ---------- ---------- ---------- RRSTLLPPPP LNTTPTPPPP LPAPPPRVVP PPLTTLLVVV PRIIVVPLCH HRSLVVVIME ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MA ---------- ---------- ---------- ---------- ---------- --------MG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -KREFFF--- ---------- ---------- ---------- ---------- ---------- -KFIVVVSMH ---------- -MMAIVVPKR DTTFYSSPKM AMKAPPEYVA CLLLYYYTIN RRRADFIIVD ---------- ----MAAKKP DTTFYTTPRD AMRAPPEYVA ALLLYYYTVN AAAPDFLLVD ---------- -----MMSRP DTTFHSSPEL AMQAPAEYTL LLLLSSSF-- RRRPDALLID ---------- -----MMTRP DTTFHSSPKL AMEAPAEYTL LLLLSSSF-- KKKPDALLID ---------- -----MMTRP DTTFYSSAKL AMEGPVEFTL MLLLSSSA-- KKKPDGLLVD ---------- ----MAATKP DSSFYSSPRL AAKAPPEYVA MFFFDDDR-- QQQPDAIIVD ---------- ----MVVTRP DTTFYSSPRM AVKAPAEYVV RLLLNNNAG- KKKPDAMMVD ---------- ----MAASRP DTTFYSSPKM AMQAPREYVA LLLLDDDR-- RRRPDALLLD ---------M MTTKCTTK-C GGGYPPPLEA MK-GPREYLP CIIIYYYTTE AAAPDYLLVD ---------- ---------- ---------- -M-GPREYLP CIIIYYYTIE AAAPDYLLVD PPAAGLLP-H HTTQCGGK-C GGGYPPPLEA MK-GPREYLP CIIIYYYTIE AAAPDYLLVD ---------- ---------- ---------- MK-GPREYLP CIIIYYYTIE AAAPDYLLVD ---------M MTTKCGGN-C GGGYSPPLEA MK-GPREYLP CIIIYYYTTE AAAPDYLLVD VVAAPMMPAT TTTKCGGN-C GGGYSPPLEA MK-GPREYLP CIIIYYYTTE AAAPDYLLVD ---------M MTTKCGGN-C GGGYSPPLEA MK-G------ --------TE AAAPDYLLVD ---------M MTTKCGGN-C GGGYSPPLEA MK-GPREYLP CIIIYYYTTE AAAPDYLLVD FFLLGQQWET TTTKCGGD-C GGGYPPPQEA MK-GPREYLP CIIIYYYTTE AAAPDYLLVD LLHHYCCLFS STTKCGGN-C GGGYSPPLEA MK-GPREYLP CIIIYYYTTE AAAPDYLLVD ---------M MTTKCGGN-C GGGYSPPLEA MK-GPREYLP CIIIYYYTTE AAAPDYLLVD AAAAVEEAAN NKKTCCCHAK GGGYAPPLEA MEKGPREYVT CVVVYYYTIN KKKLDYLLVD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AAKCGGS-C GGGYKPPLDA MK-GPREYLP CIIIYYYTIN KKKPDYLLVD VVLLHGGVEK K--VNGGCKS GGGYAPPIES MS-GPREYVT AVVVYYYTIE KKKPDYLLVD VVLLHAAVEV VNNQQGGCKS GGGYAPPLEA MS-GPREYVT AVVVYYYTIE KKKPDYLLVD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RMMLVG GGGYAPPLAA MS-GPSEYVT AVVVYYYTID KKKPDYLLVD -------AAN NAAACCCGAT GGGYAPPLEA MEKGPREYVT CVVVYYYTIN KKKPDYLLVD -------MPC CLLKCHHG-- GGGYAPPADA IK-GPREFVT APPP---NAD GGGPDAIIVD -------M-C CLLKCHHG-- GGGYAPPADA IK-GPREFVT APPP---HRD GGGPDAIIVN ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMSESSKKC GGGYAPPLDA VRNGPVEYVV CVVVQQQLEE HHHGDYLLVD ---------- ---------- ---------- MRSGPREYTV TVVVQQQLEP HHHGDYLLVD ---------- ---------- MGGLI---DI LISLDDRFSN WLLLHHHIQY DDDITDRRPR ----ALLA-L LMMGLPPFAF AEETCSSPYM PKITGQEYVW TLLLGGGGGD EEEQDKLLID AALLALLSLL LLLAAPPAVR AEETCSSPYM KKITGQEYVW TLLLGGGGGD EEEQDKLLVD NNKSSETYYS KIVVHHKVEL IELHFGGWNA ACSSACCPPP G-PIRRFFLL LVPPLLRSIY DDKSSPTYYG KVIIYYKLDL IELHFGGWNA ACSSACCPPP A-PLRRYYLL LVPPLLRSIY KKGSSSTYYG KIVVHHTVTM TEFHFGGWNA ACSSSSSPPP TGALRRFFLL LIPPLLRSIY KKGSSPTYYG QIVVHHTVTM KEFHFGGWNA ACSSASSPPP AGAIRRYYLL LIPPLLRSIY DDTSSEKFFG QIVVHHQLIM KEFHFGGWNA ACSSASSPPP TGALRRYYLL LIPPIIRSIY DDASSPRYYA SIVVGGQVAM AELHFGGWNA ACSSCCCPPP APPMRRYYLL LVPPLLRSIY DDQSSSTFFG QVVVGGVTDM TELHFGGWNA ACSSMCCPPP APPVRRYYLL LVPPIIRSIT DDDSSGTYYA QIVVGGRVEM AELHFGGWNA ACSAACCPPP APPVRRYYLL LVPPIIRSIH DDKSSPQYYS QVIIHHRLPM LELHSGGWNT TCSSC----- FGSKRRKKLL LLPPLLMSIY DDKSSPHYYS QVIIHHRLPM LELHSGGWNT TCSSC----- FGSKRRKKLL LLPPIIISIY DDKSSPQYYC QVIIHHRLPM LELHSGGWNA ACSSC----- FGSKRRKKLL LLPPLLMSIY DDKSSPQYYC QVIIHHRLPM LELHSGGWNT TCSSC----- YGIKRRKKLL LLPPLLISIY DDKSSPQYYC QVIIHHRLPM LELHSGGWNT TCSSC----- FGSKRRKKLL LLPPLLISIY DDKSSPQYYC QVIIEE---- ---------- ---------- ---------- ---------- DDKSSPQYYC QVIIHHRLPM LELHSGGWNT TCSSC----- FGSKRRKKLL LLPPLLISIY DDKSSPQYYC QVIIHHRLPM LELHSGGWNT TCSSC----- FGSKRRKKLL LLPPLLISIY DDKSSPQYYS QVIIHHRLPM LELHSGGWNT TCSSC----- FGSKRRKKLL LLPPFFISIY DDKSSPQYYC QVIIHHRLPM LELHSGGWNT TCSSC----- FGSKRRKKLL LLPPLL---- DDKSSPQYYC QVIIHHRLPM LELHSGGWNT TCSSC----- FGSKRRKKLL LLPPLLISIY DDSSSPTYYS QVIIHHRLPV IKLHSGGWNS SCSSC----- HGPARRFFLL LLPPLLLGVY ---------- ---------M TELHSGGWNT TCSSC----- YGAKRRKKLL LLPPLLISIY DDKSSPSYYS QVIIHHRLPM VELHSGGWNT TCSSC----- YGSKRRKKLL LLPPLLISIY DDSSSPTYYS KVIIHHRLPV VELHTGGWNS SCSSC----- HGPARRFFLL LAPPLLVGIY DDNSSPTYYS KVIIHHRLPV VELHTGGWNS SCSSC----- HGPARRFFLL LVPPIIVGVY ---------- ---------M VELHSGGWNS SCSSC----- HGAARRYYLL LLPPLLIGIY DDSSSPSYYS SVIIHHRLPM VELHSGGWNS SCSSC----- HGAVRRYYLL LLPPLLIGIY DDNSSPTYYS QVIIHHRLPV VELHSGGWNA ACSSC----- HGPARRFFLL LLPPLLLGVY NNESSDTFFC QVIISSRVDV IEVHTGGWNA ACSSC----- HDPERRHHLL LVPPLLNDIY NNESSETFFC QIIISSRVDV IEVHTGGWNA ACSSC----- HDPERRHHLL LVPPLLNDIY ---------- ---------- ---------- ---------- --------MM MPRRLLSGEG DDASSPTYYC QVIIHHRTYT KELHSGGWNT TCSSCFFPPP GGEPRRRRLL LLPPLLNDIF DDESSPTYYC QIVVHHRTFT KELHSGGWNA ACSSCYYDDD SSTPRRRRLL LLPPLLNDIY VVQVVFLGGG SVLLKKDGPV LKELSQQPTP PRILK----- -GRQGGQQMM MQLLLLDKLY RRGSSATRRG QVIINNSVSV -EAHGGGFSA A--------- ----RRFFFF FTGGLLDNIF NNKSSPQYYG KVVVNNTLSV -EAHSDDFTD D--------- ----RRYYLL LAGGLLDSIF IIKPNNNVIE EPEVVVVGGG GSSRRHTVVC CGGGDAAIII YYYSAALGGN NEEE----EE IVKPDDDIVE EPEAAARGGG GTTKKHTVVC CGGGDAAIII YYYSAALGGG GPPP----DE VIKPHHHIIE EPDIIIKGGG GSSRRHTVVC CGGGEGGIII YYYSTTLGGG GAAAGKKKDD IIKPDDDIIE EPEVVVKGGG GSSRRHTIIC CGGGDGGIII YYYSTTLGGG GGGGGKKKDN IVK-EEEIIE EPEVVVKGGG GSSRRHTIIC CGGGEGGIII YYYSTTLGGG GGGGGEEEDD ILKPDDDVIE EPELLLRGGG GSSRRHTVVC CGGGGGGIII YYYTAALGGN NAAA----EK ILKPDDDVID DPNLLLRGGG GAARRHTVVC CGGGDGGIII YYYSAALGGS SPPP----EE IVKPDDDVIE EPELLLRGGG GSSRRHTIIC CGGGDGGVVV YYYSAALGGS SPPP----ED VVGSEEEVIE EASIIIKNNN NSSNNHTSSC CLLLSGGEEE VVVVNNTLLG GDDD----LN VVGSEEEVIE EPNIIIKNNN NGGNNHTSSC CLLLSGGEEE VVVISSSLLG GDDD----PN VVGSDDDVIE EAEIIIKGGG GGGYYHTSSC CLLLSGGEEE VVVISSTLLG GDDD----SN VVGTEEEVIE EPKIIIKNNN NGGFFHTSSC CLLLSGGEEE VVVVSSTLLG GDDD----PN VVGSEEEVIE EPEIIIKEEE EAAFFHTSSC CLLLSGGEEE VVVISSSLLG GDDD----VN ---------- -PKIIIKEEE EAAFFHTSSC CLLLSGGEEE VVVISSSLLG GDDD----VN VVGSEEEVIE EPKIIIKEEE EAAFFHTSSC CLLLSGGEEE VVVISSSLLG GDDD----VN VVGSEEEVIE EPKIIIKEEE EAAFFHTSSC CLLLSGGEEE VVVISSSLLG GDDD----VN VVGTEEEVIE EAKIIIKGGG GGGTTHTSSC CLLLTGGEEE VVVISSTLLG GDDD----PN ---------- ---------- ---------- ---------- ---------- ---------- VVGSEEEVIE EPKIIIKEEE EAAFFHTSSC CLLLSGGEEE VVVISSSLLG GDDD----VN VVATDDDVVE ESEIIINGGG GGGFFHTSSC CLLLSGGDDD IIIISSCLLG GDDD----KN VVGTDDDTVE EPYVVVKGGG GAANNHTSSC CLLLCGGEEE IIIISSSIIG GDDD----PN VVGSDDDTVE EPYVVVKGGG GAANNHTSSC CLLLCGGEEE IIIISSSLLG GDDD----PN VIKTNNNVVD DPAIIIKGGG GAAYYHTSSC CLLLSGGEEE LLLISSCLLG GDDD----KN VIKTNNNVVE EPEIIIKGGG GAAYYHTSSC CLLLSGGEEE IIIISSCIIG GDDD----KN AIKENNNYVD DPKIIIKGGG GAAYYHTAAC CLLLSGGEEE IIIVSSCLLG GDDD----EN AIKENNNYVD DPKIIIKGGG GAAFFHTAAC CRRR-GGEEE IIIVSSCLLG GDDD----EN VVLKDDDVVE EAEIIIKGGG GGGFFHTSSC CLLLSGGEEE IIIISSCLLG GDDD----KN IIENEEETIE EPSLLLL--- -SSFFHTSSC CLLLDGGNNN IIIISSTLLG GEEE----AT VIENEEETIE EPSLLLL--- -SSFFHTSSC CLLLDGGNNN IIIISSTLLG GEEE----AS KVGG------ ---------- ---------- ---------- ---------- ---------- VIGTDDDVIE EG-VVVGDDD DTTAAHTTTC CLLLNGGNNN IIIISSIMMG GDDD----AN ILVTDDDTID DG-VVVSNNN NTTAAHTTTC CLLLNGGNNN IIIISSVMMG GDDD----AY VTLYSSS--- ---LLLFVVV VAAIIHTAAY YQQQNTTAAA LLLQDDGVVN NEEE----SV IFHSDDDTID DT-VVVSGGG GVVGGHTFFA ALLLGSSMMM MMMTGGLSSN NDDD----DG VFHSDDDTIT TD-VVVSGGG GVVGGHTLLA ALLLGRRMMM LLLTGGLSSN NNNN----KG EEGGPPGGIL LLDDYSSFLG GWWEEEIDGY ---------- --AAADFNEV VLLVSWV--- EEGGPPGGIF LLDDDTTFIG GWWEEEVYGY ---------- --AAADFNGV VMMITWV--- DDGGAAGGIF MMDDETTFLG GWWEEEIDGD ---------- --HHHDFNDY YMMVSWL--- NNGGPPGGVF MMDDETTFLG GWWEEEIDGT ---------- --HHHDFNDY YMMVTWL--- DDGGPPGGIF LLDDETTFLG GYYEEEMDGT ---------- --HHHDFNDY YMMVSWL--- KKGGPPGGIA LLDDQSSFLG GWWEEEVEGY ---------- --AAADGHDT TLLVTWT--- EEGGPPGGIF LLDDDNNLLG GWWEEEIDGY ---------- --HHHDFHDT TLLLTWT--- DDGGPPGGVF MMDDESSFLG GWWEEEVEGQ ---------- --AAADFHDT TMMVTWT--- NNGGKKSSFV LLDDETTFKG GWWEEEKPGP ---------- --GGGDFQNV VMMVSWA--- NNGGKKGGFV LLDDETTFKG GWWEEEKPGP ---------- --GGGDFQNI IMMVSWA--- NNGGKKGGFV LLDDETTFKG GWWEEEQPGP ---------- --GGGDFQNV VMMISWA--- NNGGKKGGFV LLDDKTTFKG GWWEEEQPGP ---------- --GGGDFQNV VMMISWA--- NNGGKKGGFV LLDDETTFKG GWWEEERPGP ---------- --GGGDFQNV VMMISWA--- NNGGKKGGFV LLDDETTFKG GWWEEERPGP ---------- --GGGDFQNV VMMISWA--- NNGGKKGGFV LLDDETTFKG GWWEEERPGP ---------- --GGGDFQNV VMMISWA--- NNGGKKGGFV LLDDETTFKG GWWEEERPGP ---------- --GGGDFQNV VMMISWA--- NNGGKKGGFV LLDDETTFKG GWWEEERPGP ---------- --GGGDFQNV VMMISWA--- ---------- ---------- ---------- ---------- ---------- ---------- NNGGKKGGSL LLLL-RRLSG G--------- ---------- ---------- -----SH--- NNAAAANNGF LLLLSEEFKG GGGSSSNRFS ---------- --EEETHEGL LFFWSQC--- NNGGKKGGFV LLDDETTFKG GWWEEEAEEP ---------- --GGGDFQNV VMMISWA--- NNGGKKGGFV LLDDETTFKG GWWEEEVEEQ ---------- --GGGDFQNV VMMISWA--- NNAAEENNGF LLLLSDDFKG GWWEEEKPHL ---------- --GGGDFQNT TMMISWA--- NNAAEENNGF LLLLSEEFKG GWWEEEKPHL ---------- --GGGDFQNT TMMISWA--- NNAAKKNNGF LLLLSDDFKN NWWEEEKPHL ---------- --GGGDFQKT TMMISWA--- NNAAKKNNGL LLLLSDDFKN NWWEEEKPIL ---------- --GGGHFQKT TMMISWA--- NNAAAANNGF LLLLSEEFKG GWWEEEKPHL ---------- --GGGDYQKT TMMISWA--- TTPPSSNNFL LLDDKTTFKG GWWPPPADKP ---------- --NNNDFQNV VMMISWS--- SSPPSSNNFL LLDDKTTFKG GWWPPPADKP ---------- --NNNDFQNI IMMISWS--- ---------- ---------- ---------- ---------- ---------- ----SRG--- NNAAKK--DF EEFFKNNFVG GWWSSSRGRL ---------- --GGGDYQNV VMMVAWA--- YYAAKK--DF LLFFSDDFIG GWWTTTKGKL ---------- --GGGDFQDV VMMVSWA--- VVPPVVNNGI TTSSHEENSA AGGEEEASFI ---------- --QQQSNNEK KSSESPE--- GGGGRRAALV YYNNDGGEAT TWWMMMPTDQ GAVAGGDVVV VGGGGDILNV VMMLTFGNYY GGGGRRAALV YYTTAGGEAT TWWIIIPTGR GAIKGG-YYY YGDDDDVLNL LLLVTFGNYY TTTEDGLKKK EEDRYGIHFF WDLRRRIIHL TLGEEENNAA -----EELRD KLMMMGGGFI CCCEEGFSSS EEEAYGLHVV WDLAHHLLYI DLGEEEHHVV -----EEVRD KLMMMGGGFV QQQENGIVVV EEAKYGLHFF WDLRNNVVQI DLGQQQHHAA -----EEVRD REYYYGGGFV QQQENGIVVV EESKYGLHFF WDLRNNVVQI DLGNNNHHAA -----EEVRD REYYYGGGFV QQQENGIVVV EESKYGIHFF WKLRNNVVQI DLGNNNHHAA -----EEIRD KDYYYGGGFC MMMEDGLVVV DDGRYGLHFF WDLTHHLLQI DFGEEEHHVV -----EELRD KAYYYGGGFV MMMESGVLLL DDAKYGLHVV WDLYHHLLQL DLGEEEYYAA -----EELRD KAYYYGGGFM MMMEGGLDDD QQNGYGLHII WDLRHHLLQL DVGEEEHHVV -----EELRD RTYYYGGGFV VVVKDGNPPP HH-LYGIFVV WDWQIIIIQL QMT---DDII ----LEEIRD ATQQQGGGFV VVVKDGNPPP HH-LYGIHVV WDWQIIIIQL QMK---DDII ----LEEIRD ATQQQGGGFV VVVRDGNPPP DD-LYGLHVV WDWQIIIIQL TLQ---DDII ----LEEIRN AAQQQGGGFV VVVRDGNPPP DD-LYGLYVV WDWQIIVVQL PLQ---DDII ----LEEIRN AAQQQGGGFV VVVRDGNPPP DD-LYGLYVV WDWQIIVVQL SLK---DDII ----LEEIRN AAQQQGGGFV VVVRDGNPPP DD-LYGLYVV WDWQIIVVQL SLK---DDII ----LEEIRN AAQQQGGGFV VVVRDGNPPP DD-LYGLYVV WDWQIIVVQL SLK---DDII ----LEEIRN AAQQQGGGFV VVVRDGNPPP DD-LYGLYVV WDWQIIVVQL SLK---DDII ----LEEIRN AAQQQGGGFV VVVQNGNPPP DD-LYGLHVV WDWQIIVVQL LMP---DDII ----LEEIRD ASQQQGGGFV ---------- ---------- ---------- ---------- ---------- ---------- LLLLTGRDDD PP-RVAT--- ---------- ---------- ---------- ---------- FFFTTGELLL CC-GVHSCLL DNYIIIDDEL PLQ---DDGG NNPILCCLRW INQQQDDDYD AAAALGKMMM EE-MYGLNVV WDWTRRIIQI DLG---DDII ----LEEIRD AAQQQGGGLV AAAALGKMMM DD-HYGLNVV WDWTLLVVQI DLG---DDII ----LEEIRN ADQQQGGGLV AAATKGDLLL HH-LYGLTCC IQLALLRRQL DLG---TTLL ----LEEIRD KDTTTGGGFV AAALQGNLLL HH-LYGLHVV YSWPIIKKQL DLG---KKLL ----LEEIRD KDTTTGGGFV AAASKGDLLL HH-LYGLHVV YSWPMMKKQI DLG---TTLL ----LEEIRD KDTTTGGGYV AAASKGNLLL HH-LYGLHVV YSWPIIKKQI DLG---TTLL ----LEEIRD KDTTTGGGFV AAARTGDLLL HH-LYGLHVV YDWPLLKKQL DLG---TTLL ----LEEVRD KDTTTGGGYV HHHKKGNPPP HH-LYGVHII FEWDYYLLQI DLPPPPLLLL ----LEEVRE SEHHHAAAFV HHHKKGNPPP HH-LYGVHII FEWDHHLLQI DLPPPPRRLL ----LEEVRE SEHHHAAAFV TTTCRDELLL CC-LVIKRVV Y--------- ---------- ---------- ---------- LLLRRGHPPP DDRQYGLNFF YRWQLLFFQI DLG---DDTT ----LEEIRN ENQQQGGGYV KKKRRGKNNN DDMQYGLNFF YKWSLLYYQI DLG---DDTT ----LEEIRN KAEEEGGGFV MMMFESESSS LLGLKPVAEE VL-------- ---------- ---------- ---------- MMMDFGMLLL DDMRFGIVQQ WDLHPPKKKF NVPAAAPP-- ----LEEIRG ANYYYAAAFS MMMDFGMLLL DDMHFGVVTT WDLHPPKKKF DVPAAAPP-- ----LEEIRG HNYYYCCCFT NNMMMVVSLK KKDSSSLFFY Y--EDGAEEK VIEIIIIAAE EPPPLEEEEN NLPPPEEIIL NNVVVLLNTK KKDSSSLFFY Y--EDGAEER VIDIIIIAAQ QPPPFEEEEP PLPPPPPVVL GGVVVVVDTT TTNGGSTWWR R--EGGVKKK TATIIIIAAE EPPPATTTTE ELPPPPPLLL GGVVVVVDTT TTNAASTWWR R--EGGAEEK TATIIIIPPE EPPPAPPPPK KLPPPPPLLL GGVVVVVDTT TTNGGATWWQ QKKDDGAKKK TITIIIIPPV VPPPADDDDD DLPPPDDLLL NNCCCIISLK KKDSSSTYYR R--DKDVRRK VIEIIIIAAE EAAAADDDDQ QLPPPPPVVL NNCCCVVSLK KKDAASLYYR R--DNGLKKK VIDIIIIAAE EPPPASSSSQ QLPPPPPIIL GGVVVVVSLE EEDAASLHHR R--QNGIRRK VIEIIIIAAE EPPPAEEEEQ QLPPPPPLLL GGCCCLLSSN NNIFFYEGG- ---------- -TWSSSSEEK KVVVIQQQQS SKKKKVVKKG GGCCCLLSSN NNIFFYEGG- ---------- -TWSSSSEEK KVVVIQQQQS SKKKKVVKKG GGCCCLLSST TTIFFYQGG- ---------- -TWSSSSEEK KVVVIQQQQP PKKKKVVKKG GGCCCLLSST TTIFFFEGG- ---------- -TWSSSSQQK KVVVIQQQQP PKKKKVVKKG GGCCCLLSST TTIFFYEGG- ---------- -TWSSSSEEK KVVVIQQQQP PKKKKVVKKG GGCCCLLSST TTIFFYEGG- ---------- -TWSSSSEEK KVVVIQQQQP PKKKKVVKKG GGCCCLLSST TTIFFYEGG- ---------- -TWSSSSEEK KVVVIQQQQP PKKKKVVKKG GGCCCLLSST TTIFFYEGG- ---------- -TWSSSSEEK KVVVIQQQQP PKKKKVVKKG GGCCCLLSST TTIFFYEGG- ---------- -TWSSSSEEK KVVVIEEEEP PKKKKVVKKG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVVVVVSFS SSGGGSDYY- ---------- -AVVVVVKKR RKKKLDDDDY YAVVVVVAAK GGCCCLLSST TTVFFYKGG- ---------- -KWAAAAEEK KVVVIKKKKS SKKKKVVEEG GGCCCLLSSS SSIFFYKGG- ---------- -KWAAAAEEK KVVVIQQQQS SKKKKVVEEG GGSSSLLSSN NNMFFFQGG- ---------- -SWSSSSEEL LAAAIPPPPP PLKKKVVQQN GGSSSLLTSN NNMFFFQGG- ---------- -SWNNNNEEI IVVVISSSSP PLKKKVVQQN GGSSSLLSSN NNMFFFSDD- ---------- -TWSSSSEEI IVVVISSSSP PLKKKVVEEN GGSSSLLSSN NNMFFFSEE- ---------- -TWSSSSEEV VVVVISSSSP PLKKKVVEEN GGCCCLLTSN NNMFFFAGG- ---------- -SWSSSSEEV VAAAISSSSP PLKKKVVRRN GGCCCLLGSG GGIIIHENNS S--------T -THAAAATTL LVVVAFFFFS SKKKKVVSSG GGCCCLLGSA AAIIIHENNP P--------K -VQTTTTSSL LVVVATTTTS SKKKKVVEEN ---------- ---------- ---------- ---------- ---------- ---------- GGCCCFFXXX XXXXXX---- ---------- ---------- ---------- --QQQGGEEN GGCCCLLNAK KKVFFKSSSD D--------E FEAKKKKVVI IDDDIPPPPL LVDDDTTGGS ---------- ---------- ---------- ---------- ---------- ---------- TTTTTLLTSQ QQLIIYDGG- ---------- ---------- -----EEEEA AKAAAVVAAD SSTTTLLTSQ QQLIIYGGG- ---------- ---------- -----EEEEA AKAAAVVAAD LLFFKAVPPP VISLDDFLYL LLLWWGERRQ DSNNNKPPPP VLTTGGKKGI FFHHHRDDPP LLFFKMVPPP VISLDDFLYV VLLWWGERRQ DTNNNQPPPP RLAAGGRRGL YYHHHRPPPP LLFFGAVPPP VISLDDFLYV VCCWWGERRQ DSDDDNPPPP VLAAGGSSGI AARRRRPPPP LLFFGAVPPP VISMDDFLYV VCCWWGERRQ DSDDDKPPPP KLAAGGSSGI AARRRRPPPP LLFFGACPPP VISLDDYLYV VCCWWGEHHQ DSDDDNPPPP VLTTGGKKGI VVKKKKPPPP LLFFKAVPPP VISMDDFLYV VCCWWGDLLQ DSDDDEPPPP KLTTGGKKGI VVSSSRTTPP LLFFKAVPPP VISVDDFLYV VCCWWGEHHQ DSDDDNPPPP RLTTGGKKGI VVRRRRGGPP LLFFGAVPPP VISLDDFLYV VCCWWGERRQ DSDDDNPPPP RHTTGGSSGI VVRRRKAAPP GGLLPEMPGG IISLDDFLYF FNNWWGDRRQ DSNNNKPPPP RLTTGGQQGS IIVVVRGGVV GGLLPEMPGG IISLDDFLYF FNNWWGDRRQ DSNNNKPPPP RLTTGGQQGS IIVVVKGGVV GGLLPEMPGG IISLDDFLYF FNNWWGDRRQ DSDDDRPPPP RLTTGGQQGS IIVVVKGGVV GGLLPEMPGG IISLDDFLYF FNNWWGDRRQ DSDDDRPPPP RLTTGGQQGS IIVVVKGGVV GGLLPEMPGG IISLDDFLYF FNNWWGDRRQ DSDDDRPPPP RLTTGGQQGS IIVVVKGGVV GGLLPEMPGG IISLDDFLYF FNNWWGDRRQ DSDDDRPPPP RL-------- ---------- GGLLPEMPGG I--------- ---------- ---------- ---------- ---------- GGLLPEMPGG IISLDDFLYF FNNWWGDRRQ DSDDDRPPPP RLTTGGQQGS IIVVVKGGVV GGLLPEMPGG IISLDDFLYF FNNWWGDRRQ DSDDDRPPPP RLVVGGQQGS IIVVVKGGVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKVVVSLSNN FAFFSSLIIF FSS------- ---------- ---------- ---------- GGLLPEMPGG IISLDDFLYF FNNWWGDRRQ DTDDDNPPPP KLVVGGQQGS IILLLRGGVV GGMMPEMPGG IISLDDFLYF FNNWWGDRRQ DTDDDNPPPP KLVVGGQQGS IIQQQRGGVV NNLLPEMPGG IFSLDDFLYF FNNWWGDRRQ NEDDDNPPPP VLTTGGQQGL IIQQQKSSVV NNLLPEMPGG IFSLDDFLYF FNNWWGDRRQ NEDDDNPPPP KLTTGGQQGL IIQQQKSSVV NNLLPEMPGG IFSLDDFLYF FNNWWGDRRQ NEDDDNPPPP VLTTGGQQGL LLQQQKSSVV NNLLPEMPGG IFSLDDFIYF FNNWWGDRRQ NEDDDNPPPP VLTTGGQQGL LLQQQKSSVV NNLLPEMPGG IFSLDDYLYL LNNWWGDRRQ NEDDDKPPPP VLAAGGQQGL LLQQQKSSVV GGLLPEMPAA IISMDDFLYV VCCWWGDRRQ DSDDDKVVVV KLNNSSQQGS VVHHHTSSVV NNLLPDMPAA IISMDDFLYV VCCWWGDRRQ DSDDDNPPPP KLNNSSQQGS IIHHHSTTVV ---------- ---------- ---------- ---------- ---------- ---------- NNIIEMMGGG MISLDDYLYF FNNWWGDRRQ DSDDDNPPPP RLTTGGQQGA IIQQQRAARR SSAAEDMGGG IISLDDFLYV VCCWWGDRRQ DTDDDNPPPP KLTTGGQQGA IICCCSLLNN ---------- ---------- ---------- ---------- ---------- ---------- DDNNPADIPP PIAADDTLWI ISSFFGKRRL DSDDDKPPPP FQIIYYEEDQ VVNNN----- DDEEPAKVPP PISNDDRLWV VTTFFGKRRL DSDDDHPPPP RQVVYYEEGQ VVNNN----- ---------- --------AG GGHKLTTGAP PQLLLEDGGG RVYYVTNNYY YTTNNQYYPG ---------- --------SG GGAEATTGAP PQIIISDGGG RVYYITNNYY YSSNNQYYPG ---------- --------NG GGRTFAAGGP PQVVVEDGGG RVYYWTNNYY YTTDDQYYPG ---------- --------NG GGKAFAAAGP PQVVVEDGGG RVYYWTNNYY YTTDDQYYPG ---------- --------NG GGKTFGGYGP PQVVVEDGGG RVYYWTNNYY YTTEEQYYPD ---------- --------KN NNGALNNGGP PQVVVEDGGG RVYYFTNNYY YAAPPQYYPG ---------- --------TS SSAELNNGGP PQVVVEDGGG RVYYFTNNYY YAAEEQYYPG ---------- --------AS SSGPLNNGGP PQVVVEDGGG RVYYFSNNYY YSSEEQYYPG ----DDEELL TTQQQEPLKG GGKRIPPGGP PQIIIQDGGG RLYYATTTYY YDDKKQYY-D ----DDEELL TTQQQEPLKG GGKRVPPGGP PQIIIQDGGG RLYYVTTTYY YAAKKQYY-N ----DDEELL KKQQQEPLKG GGKKVPPGGP PQIIIQDGGG RLYYVTTTYY YAAKKQYY-D ----DDEELL DDQQQEPLKG GGKQVAAGGP PQIIIQDGGG RLYYVTTTYY YAAKKQYY-D ----DDEELL KKQQQEPLKG GGKRVAAGGP PQIIIQDGGG RLYYITTTYY YAAKKQYY-D ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----DDEELL KKQQQEPLKG GGKRVAAGGP PQIIIQDGGG RLYYITTTYY YAAKKQYY-D ----DDEELL KKQQQEPLKG GGKRVPPGGP PQIIIQDGGG RIYYVTTTYY YDDKKQYY-D ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----DDDDLL EEQQQDPVKG GGKKVPPGGP PQIIIQDGGG RLYYVTNNYY YKKKKQYY-D ----DDEELL EEQQQDPVKG GGKIIPPGGP PQIIIQDGGG RIYYVTSSYY YIIKKQYY-D ----EEGGKK TTQQQDVPQG GGQKLRRGGP PQIIIQDGGG RLYYVTNNFF FAAKKQYY-G ----DDGGEE TTQQQDVPQG GGKKLRRGGP PQIIIQDGGG RLYYVTNNFF FAAKKQYY-K ----EEGGNN SSQQQDVPKG GGKSLRRGGP PQIIIQDGGG RLYYATNNFF FAARRQYY-E ----EEGGNN TTQQQEVPKG GGKSLRRGGP PQIIIQDGGG RLYYATNNFF FAAVVSYY-E ----EEDDKK EEQQQSVPKG GGHRLRRGGP PQIIIQDGGG RIYYVTNNFF FRREEQYYGD ----GGKK-- --PPPEALKG GGRKIEEGGP PQLLLQDGGG RLYYVTTTYY YKKDDQYY-E ----EEHHDD --EEEPALKG GGRQIEEGGP PQLLLQDGGG RLYYVSTTYY YKKDDQYY-E ---------- ---------- -------GGP PAIIIQDGGG RLYYVTNNYY YTTKKQYY-N ----DDEELL KKAAAEPVKG GGRRLLLGGP PQLLLQDGGG RLYYVSSSFF FPPKKQYY-E EEEEDDEELL KKRRRPARKG GGRRLEEGGP PQLLLQDGGG RLYYVSSSYY YPPKKQYY-K ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --VVVSDGGG RVYYFSSSLL LNN------- ---------- ---------- ---------- --VVVSDGGG RLYYYTSSLL LNN------- LKGWMVKLLN AAAAN----- -GGGGLEIDD DFVDDGGE-- -VRRRRLLGG DSSSDSYYYY LRGWMAKVVN VVVVN----- -GGGGLELEE EFVDDGGR-- -VRRRRLLGG DSSSDSFFYY VPAAQVLAAH AAAAG----- -GGGGLTLAA AWVEEPPDGG -IRRRRLLGG DSSSDSFFYY VPGVEVMAAN VVVVG----- -GGGGLELDD DFVSSPPDGG -IRRRRLLGG DSSSDSFFYY RGAAMVMAAN VVVVG----- -GGGGLTLDD DWVDDPPAGG -IRRRRLLGG DSSSDSFFYY IDGWMVKLLD AAAAG----- -GGGGIEFDD DFLEEPPKGG -VRRRRLLGG DSSSDSYYYY IKGWMVKVVD VVVVN----- -GGGGMQFDD DFVDDGGE-- -IRRRRLLGG DSSSDSYYFF IRGWIAKAAE AAAAD----- -GGGGLSLDD DFTEEGGDGG -IRRRRLLGG DSSSDSYYYY LIREGSVMML QQQQVDDDDD TGGGGLKLNN NLVDDGGKEE PLRRRRYYGG DSSSDIWW-- LIREGSVMML QQQQIDDDDD TGGGGLKLNN NLVDDGGKEE PLRRRRYYGG DSSSDIWW-- LIREGSVMML QQQQIDDDDD TGGGGLKLNN NLVDDGGKEE PLRRRRYYGG DSSSDIWW-- LIREGSVMML QQQQIDDDDD TGGGGLTLNN NLVDDGGKEE PLRRRRYYGG DSSSDIWW-- LIREGSVMML QQQQVDDDDD TGGGGLKLNN NLVDDGGKEE PLRRRRYYGG DSSSDIWW-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LIREGSVMML QQQQVDDDDD TGGGGLKLNN NLVDDGGKEE PLRRRRYYGG DSSSDIWW-- LIREGSVMML QQQQIDDDDD TGGGGLKLNN NLVDDGGKEE PIRRRRYYGG DTTTDIWW-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MIKEGSVMML QQQQIDDDDD TGGGGLKLNN NLVDDGGKEE PLRRRRYYGG DSSSDIWW-- LLKEGAVMML QQQQIDDDDD TGGGGLKLNN NLVDDGGKEE PIRRRRYYGG DTTTDIWW-- LVEKGSHIIL QQQQIDDDDD TGGGGLKINN NFVDDGGAEE PMRRRRYYGG DTTTDIWW-- LVEQGSHIIL QQQQIDDDDD TGGGGLKINN NFVDDGGAEE PMRRRRYYGG DTTTDIWW-- LMDKGSHIII QQQQIDDDDD TGGGGLSINN NFVDDGGDEE PMRRRRYYGG DTTTDIWW-- IMEKGSHIII QQQQIDDDDD TGGGGLTINN NFVDDGGDEE PMRRRRYYGG DTTTDIWW-- LVKKGSHMML QQQQIDDDDD TGGGGLSINN NFVDDGGAEE PMRRRRYYGG DTTTDIWW-- HVKSGATMMV QQQQVNNNDD PGGKKMEINN NLIDDGGKII PMRRRRYYGG DTTTDIWW-- NVRSGATMML QQQQIDDDDD PGGHHMVINN NLIDDGGKVV PMRRRRYYGG DTTTDIWW-- VVKEGSVMML QQQQIDDDDD TGGGGLTVNN NLVDDGGKEE PIRRRRFFCG DTTTDILL-- MVAAGGTIIV QQQQLDDDDD VGGGGMKLNN NLVDDGGGEE PMRRRR---- ---------- MVSQGGHIIV LLLLIDDDDD TGGGGISLNN NLVDDAANEE PMRRRRYYGG DTTTDIWWAA ---------- ---------- ---------- ---------- ---------- ---------- --KKGKDDDA QQQQYLLLAA YDDGGKELVV VAVDDYYELL -MRRRRFFSS AYYYS----- --KKGKDDDE QQQQFLLLLL YDDGGKELKK KAIDDYYAEE -MRRRRFFAR AYYYGPAADD Y------ Y------ YVV---- YVV---- YVV---- Y------ F------ Y------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AAA---- ------- ------- DRRQQEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSSSSAKK KAKKKKQPPE ATPRAAVPTL AAARLLAAAD MMTTTTQLLT PPGGGPPRRR gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIKKKAAAFS VLLLAASRRS SSGRTTRSVL LVVVVSSSKV VVVVSQAVVQ WHWWLPPGHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----EEREE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MGGLKKEPP ---------- ---------- ---------- ---------- ---------- LKNNSGGCGG ---------- ---------- ---------- ---------- ---------- ---------- ------RSTP NRRRTTPHHP PPAPSSPPHV VPPPPRRRYT IIIIVPPLLP CPHHAHHSVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MRRRFF ---------- ---------- ---------- ---------- ---------- ----MRRFVV ---------- ---------I VVFKKRPPTF YPPPPKKKKM AAKAPPEEDA AVVVCLLLYY ---------- ---------M AALKKPPPTF YPPPPRRRRD AARAPPEEDA AVVVALLLYY ---------- ---------- MMMRRPPPTF HAAAPEEEEL AAQAPPEEEA ATTTLLLLSS ---------- ---------- MMMRRPPPTF HAAAPKKKKL AAEAPPEENA ATTTLLLLSS ---------- ---------- MMLRRPPPTF YPPPAKKKKL AAEGPPEEKA ATTTMLLLSS ---------- ---------M AAWKKPPPSF YPPPPRRRRL AAKAPPEETA AVVVMFFFDD ---------- ---------M VVWRRPPPTF YPPPPRRRRM AAKAPPEEKA AVVVRLLLNN ---------- ---------M AAWRRPPPTF YPPPPKKKKM AAQAPPEERG GVVVLLLLDD ---------- -------MAC TT---CPPGY PTTTLEEEEA MM-GPPEEEV VLLLCIIIYY ---------- ---------- ---------- ---------- ---GPPEEEV VLLLCIIIYY GAVVLLIARR LPPPG-AHSC GG---CPPGY PSSSLEEEEA MM-GPPEEEV VLLLCIIIYY ---------- ---------- ---------- ---------- MM-GPPEEEI ILLLCIIIYY ---------- -------MAC GG---CPPGY STTTLEEEEA MM-GPPEEEV VLLLCIIIYY GATTLLQAQQ RPPPIASTAC GG---CPPGY STTTLEEEEA MM-GPPEEEV VLLLCIIIYY ---------- -------MAC GG---CPPGY STTTLEEEEA MM-G------ ---------- ---------- -------MAC GG---CPPGY STTTLEEEEA MM-GPPEEEV VLLLCIIIYY GHAAQQPLSS LWWWQEDTAC GG---CPPGY PTTTQEEEEA MM-GPPEEEV VLLLCIIIYY FDTTNNTHTT TLLLVFTSPC GG---CPPGY STTTLEEEEA MM-GPPEEEV VLLLCIIIYY ---------- -------MAC GG---CPPGY STTTLEEEEA MM-GPPEEEV VLLLCIIIYY LQIIMMEAAA TAAAAAANGC CCTAAKPPGY ATTTLEEEEA MMKGPPEEKV VVVVCVVVYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MC GG---CPPGY KSSSLDDDDA MM-GPPEEEV VLLLCIIIYY ----MMALDD VVVVNEKKSN GGCKKSPPGY ASSSIEEEES MM-GPPEESI IVVVAVVVYY ----MMGLQQ VVVVSEKVNQ GGCKKSPPGY ASSSLEEEEA MM-GPPEETI IVVVAVVVYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R MMQVVGPPGY ATTTLAAAAA MM-GPPEEKI IVVVAVVVYY ---------- MAAAAAANGC CCGAATPPGY ATTTLEEEEA MMKGPPEEKL LVVVCVVVYY ---------- -MMMSPNCGC HH----PPGY ASSSADDDDA II-GPPEEEL LVVVAPPP-- ---------- -MMMP--CPC HH----PPGY ASSSADDDDA II-GPPEEEL LVVVAPPP-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------E SSCKKCPPGY ATTTLDDDDA VVNGPPEEKL LVVVCVVVQQ ---------- ---------- ---------- ---------- MMSGPPEEKL LTTTTVVVQQ ---------- ---------- ------PPGL ITTT-DDDDI LLSLDDRRFY YSSSWLLLHH G--------- AAAAG-ALAL PPRAAFDDET CQQQPYYYYM PPITGGEEEV VVVVTLLLGG SGSSMMHLRR VSSSGLALAA PPGVVRDDET CAAAPYYYYM KKITGGEEDV VVVVTLLLGG TTTTGNNRRA ADFFFIAVDV VVPPKSSEEE EYKIVVKKEE PYINDDHGWW SSLCPNGPNN VVTTGNNAAP PDFFFLAVDV VVPPKSSPPP PYKVIIKKDD PYIGDDHGWW SSYCPNAPFF PPFFS--RRP PDAAALAVDV VVPPGSSSSS SYKIVVTTTT PNTGDDHGWW SSLSPLTAFF PPFFS--KKP PDAAALAVDV VVPPGSSPPP PYQIVVTTTT PNKGDDHGWW SSLSPLAAFF PPAAS--KKP PDGGGLAVDV VVPPTSSEEE EFQIVVQQII PNKGDDHGWW SSLSPLTAFF PPRRK--QQP PDAAAIAVDV VVPPASSPPP PYSIVVQQAA PHAGDDHGWW SSLCPNAPHH PPAAN--KKP PDAAAMCVDV VVSSQSSSSS SFQVVVVVDD PYTGGGHGWW SSLCPNAPHH PPRRE--RRP PDAAALGVDL LLPPDSSGGG GYQIVVRREE PNAADDHGWW SALCPYAPHH RRTTGEEAAP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PYLKDDHGWW SS----FSTT RRTTGEEAAP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PHLKDDHGWW SS----FSTT GGTTGEEAAP PDYYYLATDI IIPPKSSPPP PYQVIIRRPP PNLRDDHGWW SS----FSTT RRTTGEEAAP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PHLKDDHGWW SS----YITT RRTTGEEAAP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PNLKDDHGWW SS----FSTT RRTTGEEAAP PDYYYLATDV VVPPKSSPPP PYQVII---- ---------- ---------- -----EEAAP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PNLKDDHGWW SS----FSTT RRTTGEEAAP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PNLKDDHGWW SS----FSTT RRTTGEEAAP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PYLKDDHGWW SS----FSTT RRTTGEEAAP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PNLKDDHGWW SS----FSTT RRTTGEEAAP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PNLKDDHGWW SS----FSTT NNTTGNNKKL LDYYYLATDL LLPPSSSPPP PYQVIIRRPP IHIGDDHGWW SS----HPSS ---------- ---------- ---------- ---------- PNTNDDHGWW SS----YASS RRTTGNNKKP PDYYYLATDV VVPPKSSPPP PYQVIIRRPP PNVNDDHGWW SS----YSSS AATTGEEKKP PDYYYLATDV VVPPSSSPPP PYKVIIRRPP PYVGDDHGWW SS----HPSS AATTGEEKKP PDYYYLATDL LLPPNSSPPP PYKVIIRRPP PYVGDDHGWW SS----HPSS ---------- ---------- ---------- ---------- PFVGDDHGWW SS----HASS TTTTGDDKKP PDYYYLATDV VVPPSSSPPP PYSVIIRRPP PFVGDDHGWW SS----HASS NNTTGNNKKP PDYYYLGTDV VVPPNSSPPP PYQVIIRRPP THVGDDHGWW SS----HPSS --NNADDGGP PDAAAIFTDV VVPPESSDDD DFQVIIRRDD PHIGDDHGWW SS----HPTT --HHADDGGP PDAAAIFTNV VVPPESSEEE EFQIIIRRDD PNIGDDHGWW SS----HPTT ---------- ---------- ---------- ---------- ---------- ---------- PPLLDEEHHG GDYYYLATDV VVPPASSPPP PYQVIIRRYY NSKHNNHGWW SSHFP-GEVV PPLLDPPHHG GDYYYLSTDV VVPPESSPPP PYQIVVRRFF NRKGDDHGWW SSYYDESTVV GGIIRYYDDI ITDDDRKNRM MMGGQVVFFF FGSVLLDDPP KVLEDDLQPP IL-----RVV VVGGMDDEEQ QDKKKLVTDL LLPPGSSAAA ARQVIISSSS GG-RNNHGFF ---------- AAGGVDDEEQ QDKKKLVTDA AAPPKSSPPP PYKVVVTTSS GG-RNNHDFF ---------- NRFFIPPPGG GGGLRRSSSY IIDTKPNNPE EKIIKVIIPE EEEEKYRTVV HHCCGGGPAA FRYYIPPPAA AAALRRSSSY VVDTKPDDKR RAVVKIVVPE EEEVGYKTVV HHCCGGGPAA FRFFIPPPGG GGGLRRSSSY IIDTKPHHPQ QRIIKIIIPD DDDEAYRTVV HHCCGGGPGT FRYYIPPPGG GGGLRRSSSY IIDTKPDDPK KKIIKIIIPE EEEEKYRTII HHCCGGGPGT FRYYIPPPGG GGGIRRSSSY VVDVK-EEPK KKIIKIIIPE EEEEAYRTII HHCCGGGPGT HRYYVPPPGG GGGLRRSSSY LLDTKPDDPK KFLLKVIIPE EEETEYRTVV HHCCGGGPGA HRYYVPPPDD DDDIRRSSST LLDTKPDDPQ QKVVKVIIPN NNNEEYRTVV HHCCGGGPGA HRYYIPPPGG GGGIRRSSSH VVDTKPDDPE ERIIKVIIPE EEEERYRTII HHCCGGGPGA TNKKIPPPGG GGGLMMSSSY VVDVGSEEPA AKLLKVIIAS SSSEAVNTSS HHCCLLLAGN TDKKIPPPSS SSSIIISSSY VVDVGSEEPA AKLLKVIIPN NNNEALNTSS HHCCLLLAGS TTKKMPPPCC CCCLMMSSSY VVDVGSDDPA AKLLKVIIAE EEEDALYTSS HHCCLLLAGS TTKKVPPPAA AAALIISSSY VVDVGTEEPA AKLLKVIIPK KKKDTLFTSS HHCCLLLPGS TTKKVPPPSS SSSLIISSSY VVDVGSEEPA AKLLKVIIPE EEEDALFTSS HHCCLLLAGS ---------- ---------- ---------- --------PK KKKDALFTSS HHCCLLLAGS TTKKVPPPSS SSSLIISSSY VVDVGSEEPA AKLLKVIIPK KKKDALFTSS HHCCLLLAGS TTKKVPPPSS SSSLIISSSY VVDVGSEEPA AKLLKVIIPK KKKDALFTSS HHCCLLLAGS TNKKVPPPSS SSSFIISSSY VVDVGTEEPA AKLLKVIIAK KKKDELTTSS HHCCLLLPGS TTKKVPPPSS SSSL------ ---------- ---------- ---------- ---------- TTKKVPPPSS SSSLIISSSY VVDVGSEEPA AKLLKVIIPK KKKDALFTSS HHCCLLLAGS SRFFIPPPSS SSSLLLSSGY VVDTATDDPT TSLLKVVVSE EEEDELFTSS HHCCLLLAGS SNKKIPPPCC CCCLIISSSY VVDVGTDDPA ARIIKTVVPY YYYEWLNTSS HHCCLLLGGS SNKKIPPPCC CCCLIISSSY VVDVGSDDPA ARIIKTVVPY YYYEWLNTSS HHCCLLLGGS SRFFIPPPSS SSSLVVSSGY IIDTKTNNPS SSLLKVVVPA AAADQLYTSS HHCCLLLAGS SRFFIPPPGG GGGIVVSSGY IIDTKTNNPA ASLLKVVVPE EEEDTLYTSS HHCCLLLAGS SRYYVPPPSS SSSLIISSGY IIDTKENNPA ASLLKYVVPK KKKEELYTAA HHCCLLLAGS SRYYVPPPSS SSSLIISSGY IIDTKENNPA ASLLKYVVPK KKKEDLFTAA HHCCRRRTGS SRFFIPPPSS SSSLLLSSGY VVDTLKDDPA AALLKVVVAE EEEDELFTSS HHCCLLLAGS TSHHIPPPCC CCCLNNSSDY IINVENEE-K KYLLHTIIPS SSSKSLFTSS HHCCLLLAGS TSHHIPPPCC CCCLNNSSDY IINVENEE-E EYLLHTIIPS SSSKALFTSS HHCCLLLAGS ----VRRRKK KKKLSSSSGG VVFVGG---- ---------- ---------- ---------- VDRRVPPPCC CCCLNNSSDF IIDTGTDDPA AKLLKVIIG- ---DKCATTT HHCCLLLPGS VDRRVPPPSS SSSLNNSSDY LLDVVTDDPK KEIIKTIIG- ---DKVATTT HHCCLLLAGS VPQQLLLLSS SSSLDDGGKY TTTSLYSSAD DQFFP----- ---DKLITAA DDYYQQQPTD -RFFWGGGGG GGGLDDTTNF FFDVHSDDPN NKLLKTIIT- ---FDVGTFF FFAALLLPSG -RYYWGGGGG GGGLDDTTSF FFDVHSDDPR RVLLKTIID- ---FKVGTLL YYAALLLPRG LNN--E-GGI ILLMDHHSSL WWWWEEIDDD RDDQQQ---- --------AY YYYYFWWLSS LGG--DRGGI IFFLDHHTTI WWWWEEVYYY RPPQQQ---- --------AY YYYYFWWMTT LGGGKDTGGI IFFIDCCTTL WWWWEEIDDD RPPQQQ---- --------HY YYYYFWWMSS LGGGKDTGGV VFFIDCCTTL WWWWEEIDDD RPPQQQ---- --------HY YYYYFWWMTT LGGGEDTGGI IFFIDCCTTL YYYYEEMDDD REEQQQ---- --------HY YYYYFWWMSS LNN--E-GGI IAAMDAASSL WWWWEEVEEE RPPQQQ---- --------AY YYYYGWWLTT LSS--E-GGI IFFIDHHNNL WWWWEEIDDD RDDQQQ---- --------HY YYYYFWWLTT LSS--E-GGV VFFVDHHSSL WWWWEEVEEE RPPQQQ---- --------AY YYYYFWWMTT TGG--LGGSF FVVLDGGTTK WWWWEEKPPP GAASSS---- --------GY YYYYFYYMSS SGG--PGGGF FVVLDGGTTK WWWWEEKPPP GEEAAA---- --------GY YYYYFYYMSS TGG--SGGGF FVVLDGGTTK WWWWEEQPPP GAAAAA---- --------GY YYYYFYYMSS TGG--PGGGF FVVLDGGTTK WWWWEEQPPP GAAAAA---- --------GY YYYYFYYMSS SGG--VGGGF FVVLDGGTTK WWWWEERPPP GAAAAA---- --------GY YYYYFYYMSS SGG--VGGGF FVVLDGGTTK WWWWEERPPP GAAAAA---- --------GY YYYYFYYMSS SGG--VGGGF FVVLDGGTTK WWWWEERPPP GAAAAA---- --------GY YYYYFYYMSS SGG--VGGGF FVVLDGGTTK WWWWEERPPP GAAAAA---- --------GY YYYYFYYMSS TGG--PGGGF FVVLDGGTTK WWWWEERPPP GSSAAA---- --------GY YYYYFYYMSS ---------- ---------- ---------- ---------- ---------- ---------- SGG--VGGGS SLLVLPPRRS ---------- ---------- ---------- ---------- CGG--KGANG GFFLLDDEEK GGGGSSNRRR LPPIII---- --------ER RRRRHYYFSS SGG--PGGGF FVVLDGGTTK WWWWEEAEEE GAAAAA---- --------GY YYYYFYYMSS SGG--PGGGF FVVLDGGTTK WWWWEEVEEE GSSAAA---- --------GY YYYYFYYMSS CGG--KGANG GFFLLDDDDK WWWWEEKPPP GSSPPP---- --------GY YYYYFYYMSS CGG--KGANG GFFLLDDEEK WWWWEEKPPP GSSPPP---- --------GY YYYYFYYMSS CGG--EGANG GFFLLDDDDK WWWWEEKPPP GSSPPP---- --------GY YYYYFYYMSS CGG--EGANG GLLLLDDDDK WWWWEEKPPP DSSPPP---- --------GY YYYYFYYMSS CGG--KGANG GFFLLDDEEK WWWWEEKPPP GSSPPP---- --------GY YYYYYYYMSS TGG--AGPNF FLLLDGGTTK WWWWPPADDD ETTVVV---- --------NY YYYYFYYMSS TGG--AGPNF FLLLDGGTTK WWWWPPADDD GVVVVV---- --------NY YYYYFYYMSS ---------- ---------- ---------- ---------- ---------- --------SS IGG--AGA-D DFFVFDDNNV WWWWSSRGGG DKKAAA---- --------GY YYYYYYYMAA VGG--AGA-D DFFIFDDDDI WWWWTTKGGG DKKAAA---- --------GY YYYYFYYMSS GNN--SSPNG GIIQSKKEES GGGGEEASSS QEEEEE---- --------QL LLLLNNNSSS LNN--DHGAL LVVENDDGGA WWWWMMPTTT ADDMMMGVAA AVVDADDDGY YYYYIAAMTT LNN--KHGAL LVVETNNGGA WWWWIIPTTT DDDLLLGIKK KTT-KDDDDY YYYYVAALTT EWWVVPNN-- TEDDDGG-LL LLEHLDRGGN HWDLRKLTLE EENNNRRRML LL---EEELR EWWVVPRR-- CEEEEGG-FL LLECLEAGGN HWDLARIDLQ QEHHHRRRML LL---EEEVR EWWLLPPP-- QENNNGG-IP PPEDLAKGGH HWDLRRIDLA AQHHHQQQML LL---EEEVR EWWLLPPP-- QENNNGG-IP PPEDLSKGGH HWDLRRIDLA ANHHHQQQML LL---EEEVR EWWLLPPP-- QENNNGG-IP PPEDLSKGGH HWKLRKIDLA ANHHHQQQML LL---EEEIR EWWTTPDD-- MEDDDGG-LP PPDILGRGGR HWDLTRIDFD DEHHHQQQLF FF---EEELR EWWTTPRR-- MESSSGG-VG GGDELAKGGH HWDLYRLDLA AEYYYQQQML LL---EEELR EWWTTPNN-- MEGGGGG-LP PPQILNGGGR HWDLRRLDVE EEHHHQQQML LL---EEELR EWWAAPNN-- VKDDDGGFNA AAHVE-LGGS FWDWQELQM- --DDDGGGLP PP---EEEIR EWWAAPNN-- VKDDDGGFNA AAHVE-LGGS HWDWQELQM- --DDDGGGLP PP---EEEIR EWWAAPNN-- VRDDDGGFNA AADVE-LGGS HWDWQELTL- --DDDGGGLP PP---EEEIR EWWAAPNN-- VRDDDGGFNA AADVK-LGGS YWDWQELPL- --DDDGGGLP PP---EEEIR EWWAAPNN-- VRDDDGGFNA AADVE-LGGS YWDWQELSL- --DDDGGGLP PP---EEEIR EWWAAPNN-- VRDDDGGFNA AADVE-LGGS YWDWQELSL- --DDDGGGLP PP---EEEIR EWWAAPNN-- VRDDDGGFNA AADVE-LGGS YWDWQELSL- --DDDGGGLP PP---EEEIR EWWAAPNN-- VRDDDGGFNA AADVE-LGGS YWDWQELSL- --DDDGGGLP PP---EEEIR EWWAAPNN-- VQNNNGGFNA AADVE-LGGK HWDWQELLM- --DDDGGGHP PP---EEEIR ---------- ---------- ---------- ---------- ---------- ---------- ISSHHSNN-- LLTTTGGSRY YYPAS-RAAG ---------- ---------- ---------- IQQCCSLL-- FTTTTGGAEM MMCLT-GHHV CDNYIVLPL- --DDDQQQAA AANPPCCCLR EWWAAPKK-- AALLLGGFKE EEEVQ-MGGH NWDWTRIDLE E-DDDGGGLP PP---EEEIR EWWAAPKK-- AALLLGGFKE EEDVQ-HGGH NWDWTRIDLK K-DDDGGGLP PP---EEEIR SWWAAPTT-- ATKKKGGFDQ QQHVA-LGGR TIQLAELDLN N-TTTGGGLP PP---EEEIR SWWAAPKK-- ALQQQGGFNQ QQHVA-LGGR HYSWPELDLD D-KKKGGGLP PP---EEEIR SWWAAPKK-- ASKKKGGFDQ QQHVA-LGGS HYSWPEIDLE E-TTTGGGLP PP---EEEIR SWWAAPKK-- ASKKKGGFNQ QQHVA-LGGS HYSWPEIDLP P-TTTGGGLP PP---EEEIR SWWAAPAA-- ARTTTGGFDQ QQHVQ-LGGR HYDWPELDLS S-TTTGGGLP PP---EEEVR EWWSSPNN-- HKKKKGGFNA AAHVG-LGGN HFEWDKIDLQ QPLLLGGGAP PP---EEEVR EWWSSPNN-- HKKKKGGFNA AAHVP-LGGN HFEWDKIDLM MPRRRGGGAP PP---EEEVR LRRGGPVV-- TCRRRDDEEK KKCQP-LIIK RY-------- ---------- ---------- EWWAAPKK-- LRRRRGGYHT TTDCDRQGGC NYRWQEIDLD D-DDDGGGLP PP---EEEIR EWWAAPNN-- KRRRRGGWKV VVDLEMQGGC NYKWSTIDLS S-DDDGGGIP PP---EEEIR RPPEEPII-- MFEEESSSEF FFLKKGLPPQ AVL------- ---------- ---------- SFFGGWSSNN MDFFFGGQMQ QQDAEMRGGN VWDLHQFNVG GAPPP----- -----EEEIR SFFGGWNNNN MDFFFGGKMA AADPEMHGGN VWDLHQFDVG GAPPP----- -----EEEIR RPHHHDDPLM MMFIMVVVVV SKKKDLSSSS SSSSSSIIWF --DKKNAEKI IPPPLEEGGN RPHHHDDPLM MMFVVVLLLL NKKKDLSSSS SSSSSSIIWF --DKKQAERI IEPPFEEGGP RPHHHDDPEY YYFVVVVVVV DTTTNLEEEG GGGSSSIIWW --GKKHVKKA APPPATTAAE RPHHHDDPEY YYFVVVVVVV DTTTNLEEEA AAASSSIIWW --GKKHAEKA APPPAPPKKK RPHHHDDPDY YYFCVVVVVV DTTTNLQQQG GGGAAAIIFW KKDTTEAKKI IDPPADDAAD RPHHHDDPAY YYFVCVIIII SKKKDLSSSS SSSSSSIIWY --KKKAVRKI IPAAADDPPQ RPHHHDDPAY YYFMCVVVVV SKKKDLSSSA AAASSSIIWY --NSSHLKKI IPPPASSEEQ RPHHHDDPTY YYFVVVVVVV SEEEDLSSSA AAASSSVVWH --NSSGIRKI IPPPAEEPPQ RFHHHDDPTQ QQFVCALLLL SNNNIQRRRF FFFYYYKKNG ---------T TVVVIQQVVS RFHHHDDPTQ QQFVCALLLL SNNNIQRRRF FFFYYYKKNG ---------T TVVVIQQVVS RFHHHNNPAQ QQFVCALLLL STTTIQRRRF FFFYYYKKNG ---------T TVVVIQQVVP RFHHHNNPAQ QQFVCALLLL STTTIQRRRF FFFFFFKKNG ---------T TAVVIQQVVP RFHHHNNPAQ QQFVCALLLL STTTIQRRRF FFFYYYKKNG ---------T TVVVIQQVVP RFHHHNNPAQ QQFVCALLLL STTTIQRRRF FFFYYYKKNG ---------T TVVVIQQVVP RFHHHNNPAQ QQFVCALLLL STTTIQRRRF FFFYYYKKNG ---------T TVVVIQQVVP RFHHHNNPAQ QQFVCALLLL STTTIQRRRF FFFYYYKKNG ---------T TVVVIQQVVP RFHHHDDPSQ QQFVCALLLL STTTIQRRRF FFFYYYKKNG ---------T TVVVIEEVVP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RSHHHWWKNQ QQYDVEVVVV SSSSGRGGGG GGGSSSDDPY ---------A ALKKLDDLLY RFHHHDDPAQ QQLVCALLLL STTTVFRRRF FFFYYYKKEG ---------K KAVVIKKVVS RFHHHNNPDQ QQLVCALLLL SSSSIFRRRF FFFYYYKKEG ---------K KAVVIQQVVS RFHHHDDPDT TTFVSALLLL SNNNMIRRRF FFFFFFKKTG ---------S SHAAIPPVVP RFHHHDDPDT TTFVSALLLL TNNNMIRRRF FFFFFFKKTG ---------S SHVVISSVVP RFHHHDDPDT TTYVSALLLL SNNNMIRRRF FFFFFFKKND ---------T TYVVISSVVP RFHHHDDPDT TTFVSALLLL SNNNMIRRRF FFFFFFKKNE ---------T THVVISSVVP RFHHHDDPDT TTYVCALLLL TNNNMVRRRF FFFFFFKKTG ---------S SHAAISSIIP RFHHHEEPEH HHFVCALLLL GGGGIFRRRI IIIHHHPPVN --------TT TAVVAFFIIS RFHHHEEPEH HHFVCALLLL GAAAIFRRRI IIIHHHPPDN --------KV VAVVATTIIS ---------- ---------- ---------- ---------- ---------- ---------- RFHHHNNPNQ QQYVCAFFFF XXXXXXXXXX XXXXXX---- ---------- ---------- RFHHHNNPAE EEFVCALLLL NKKKVFHHHF FFFKKKKKKS --------EE EKDDIPPGGL ---------- ---------- ---------- ---------- ---------- ---------- RFWWWGGSNY YYFSTALLLL TQQQLWLLLI IIIYYYEEDG ---------- -----EEWWA RCWWWGGENY YYFTTALLLL TQQQLWLLLI IIIYYYEEDG ---------- -----EEWWA LPPPEEVPPP PPLVDIISSL KKKFLLLWGI EVVVVRRDDD DIIIISNNPP FFKPVLLLTG LPPPPPVPPP PPLVDIISSL RRRFVVLWGL ELLLLRRDDD DIIIITNNPP HHQPRLLLAG LPPPPPVPPP PPLVDILSSL RRRFVVCWGT EMMMMRRDDD DVVVVSDDPP HHNPVLLLAG LPPPPPVPPP PPLVDILSSM RRRFVVCWGT EMMMMRRDDD DVVVVSDDPP RRKPKLLLAG LPPPDDCPPP PPLVDILSSL KKKYVVCWGL EMMMMHHDDD DVVVVSDDPP MMNPVLLLTG LPPPPPVPPP PPLVDILSSM RRRFVVCWGT DLLLLLLDDD DVVVVSDDPP FFEPKLLLTG LPPPPPVPPP PPLVDILSSV RRRFVVCWGT ELLLLHHDDD DVVVVSDDPP FFNPRLLLTG LPPPPPVPPP PPLVDILSSL RRRFVVCWGT ELLLLRRDDD DVVVVSDDPP FFNPRHHHTG KKKKVVMPPP GGLIDILSSL RRRFFFNWLH DIIIIRRDDD DIIIISNNPP QQKPRLLLTG KKKKVVMPPP GGLIDILSSL RRRFFFNWLH DIIIIRRDDD DIIIISNNPP KKKPRLLLTG KKKKVVMPPP GGLIDILSSL RRRFFFNWLH DLLLLRRDDD DIIIISDDPP QQRPRLLLTG KKKKVVMPPP GGLIDILSSL HHHFFFNWLH DIIIIRRDDD DVVVVSDDPP QQRPRLLLTG KKKKVVMPPP GGLIDILSSL RRRFFFNWLH DLLLLRRDDD DIIIISDDPP QQRPRLLLTG KKKKVVMPPP GGLIDILSSL RRRFFFNWLH DLLLLRRDDD DIIIISDDPP QQRPRLLL-- KKKKVVMPPP GGLI------ ---------- ---------- ---------- ---------- KKKKVVMPPP GGLIDILSSL RRRFFFNWLH DLLLLRRDDD DIIIISDDPP QQRPRLLLTG KKKKVVMPPP GGLIDILSSL RRRFFFNWLH DMMMMRRDDD DIIIISDDPP KKRPRLLLVG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AVVVVVLSSS NNEFPAIFFF LLLLFFS--- ---------- ---------- ---------- KKKKVVMPPP GGLIDIISSL RRRFFFNWLH DIIIIRRDDD DIIIITDDPP RRNPKLLLVG KKKKVVMPPP GGLIDIISSL RRRFFFNWLH DIIIIRRDDD DIIIITDDTT RRNPKLLLVG LKKKVVMPPP GGLIDFISSL RRRFFFNWLH DIIIIRRNNN NIIIIEDDLL KKNPVLLLTG LKKKVVMPPP GGLIDFISSL RRRFFFNWLH DIIIIRRNNN NIIIIEDDVV KKNPKLLLTG LKKKVVMPPP GGLIDFISSL RRRFFFNWLH DIIIIRRNNN NIIIIEDDPP KKNPVLLLTG LKKKVVMPPP GGLIDFISSL RRRFFFNWLH DIIIIRRNNN NIIIIEDDPP KKNPVLLLTG LKKKVVMPPP GGLIDFISSL RRRYLLNWLH DIIIIRRNNN NIIIIEDDPP AAKPVLLLAG KKKKVVMPPP AALIDIISSM RRRFVVCWLH DIIIIRRDDD DIIIISDDPP LLKVKLLLNS KKKKVVMPPP AALIDIISSM RRRFVVCWLH DIIIIRRDDD DIIIISDDPP KKNPKLLLNS ---------- ---------- ---------- ---------- ---------- ---------- -QQQGGMGGG GGMMDIISSL RRRYFFNWRH DVVVVRRDDD DIIIISDDRR AANPRLLLTG VDDDTTMGGG GGMIDIISSL RRRFVVCWRH DVVVVRRDDD DIIIITDDPP EENPKLLLTG ---------- ---------- ---------- ---------- ---------- ---------- KAAAVVDIII PPLPDIIAAA QQQTIISFMD KTTTTRRDDD DIIIISDDPP HHKPFQQQIY KAAAVVKVVV PPLPDIISSN SSSRVVTFMD KTTTTRRDDD DIIIISDDPP HHHPRQQQVY KVKGGGIRAD HP-------- ---------- --GKKGMLLI ISRRDRRVTS YDDNNQFFFY RVKGGGLREP HP-------- ---------- --GEEGMIIV VSRRDRRITS YNNNNQFFFY SVRGGGIRAP HP-------- ---------- --GTTGMVVI ISRRDRRWTS YDDDDQFFFY SVHGGGIRTP HP-------- ---------- --GAAAMVVI ISRRDRRWTS YDDDDQFFFY KVEGGGIKTP HP-------- ---------- --GTTYMVVI ISRRDKRWTS YDDEEQFFFY KVRGGGIRAT HPG------- ---------- -ANAAGMVVI ISRRDRRFTS YDDPPQFFFY KVQGGGIRAG HP-------- ---------- -ASEEGMVVI ISRRDRRFTS YDDEEQFFFY SVRGGGIKAA HP-------- ---------- --SPPGMVVV VSRRDRRFSS YDDEEQFFFY QIFGGGSRGG SVQE-DDQQQ QQQPPPLLLV VVGRRGMIIL LSLLDKRATS YDDKKQFFFY QIFGGGSKGG SVQE-DDQQQ QQQPPPLLLV VVGRRGMIIL LSLLDKRVTS YDDKKQFFFY QLFGGGSKGG PVQE-DDQQQ QQQPPPLLLV VVGKKGMIIL LSLLDKRVTS YDDKKQFFFY QLFGGGSKDG PVQD-DDQQQ QQQPPPLLLV VVGQQGMIIL LSLLDKRVTS YDDKKQFFFY QLFGGGSKGG PVQE-DDQQQ QQQPPPLLLV VVGRRGMIIL LSLLDKRITS YDDKKQFFFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QLFGGGSKGG PVQE-DDEEE QQQPPPLLLV VVGRRGMIIL LSLLDKRITS YDDKKQFFFY QIFGGGSKGG PVQE-DDQQQ QQQPPPLLLV VVGRRGMIIL LSLLDKRVTS YDDKKQFFFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QIFGGGSRGG PVTE-DDKKK QQQPPPVVVI IVGKKGMIIL LSLLDKRVTS YDDKKQFFFY QIFGGGSRGG PVTE-DDKKK QQQPPPVVVT TVGIIGMIIL LSLLDKRVTS YDDKKQFFFY QLWGGGLKGS PVAG-EEDDD QQQSVVPPPE EIGKKGMIIL LTLLDKRVTS FDDKKQFFFY QVWGGGLKGS PVVK-DDDDD QQQSVVPPPE EIGKKGMIIL LSLLDKRVTS FDDKKQFFFY QIWGGGLKGS PVKG-EEDDD QQQFVVPPPQ QIGSSGMIIL LSLLDKRATS FDDRRQFFFY QIWGGGLKGS PVKG-EEDDD QQQFVVPPPQ QIGSSGMIIL LSLLDKRATS FVVVVSFFFY QVWGGGLKGS EVVT-EEDDD QQQYVVPPPQ QVGRRGMIIL LSLLDKRVTS FDDEEQFFFY QVYGGGSTES NVKE-GGEEE PPPIAALLLY YVGKKGMLLL LSLLDKRVTS YDDDDQFFFY QVFGGGSSET TVKE-EEDDD EEEIAALLLY YVGQQGMLLL LSLLDKRVSS YDDDDQFFFY ---------- ---------- ---------- -----GKIIL LSVVDKRVTS YDDKKQFFFY QVFGGGARDA PRRN-DDPPP AAAPPPVVVF FLGRRGMLLL LSLLDRRVSS FDDKKQFFFY QLFGGGASDL PNVKEDDKKK RRRPAARRRY YVGRRGMLLL LSLLDKRVSS YDDKKQFFFY ---------- ---------- ---------- ---------- ---------- ---------- EKVDDDQ--- ---------- ---------- ------MVVQ QSWWDKRFSS LDD------- EKTGGGQ--- ---------- ---------- ------MVVS SSWWDQRYTS LDD------- PGGGGWMKLL LNNN---PPL LEIIKEFFFG G---ARSQQV LSGGGGGDDD ASDDSY---- PGGGGWMKVV VNNN---PPL LELLKEFFFG G---ARAQQV LWGGGGGDDD ATDDSF---- PGGGAAQLAA AHGG---PPL LTLLDDWFFP P---YRAQQI LEGGGGGDDD CTDDSFVVKK PGGGGVEMAA ANGG---GGL LELLKDFFFP P---YRAQQI LEGGGGGDDD CTDDSFVV-- PDDDAAMMAA ANGG---EEL LTLLKDWFFP P---YRSQQI LEGGGGGDDD CTDDSFVV-- PGGGGWMKLL LDGG---PPI IEFFPKFWWP P---HRPQQV LQGGGGGDDD CSDDSY---- PGGGGWMKVV VDNN---PPM MQFFPNFFFG G---QRVQQI LQGGGGGDDD ASDDSY---- PGGGGWIKAA AEDD---PPL LSLLPGFVVG G---LRPQQI LEGGGGGDDD SSDDSY---- -DDDREGVMM MLVVDVDVVL LKLLPNLFFG GPPGALAEEL YPGGGGGDDD CSDDIW---- -NNNREGVMM MLIIDVDAAL LKLLPNLFFG GPPGALAEEL YPGGGGGDDD CSDDIW---- -DDDREGVMM MLIIDVDVVL LKLLPNLFFG GPPGALAEEL YPGGGGGDDD CSDDIW---- -DDDREGVMM MLIIDVDVVL LTLLPNLFFG GPPGALAEEL YPGGGGGDDD CSDDIW---- -DDDREGVMM MLVVDVDVVL LKLLPNLFFG GPPGALAEEL YPGGGGGDDD CSDDIW---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -DDDREGVMM MLVVDVDVVL LKLLPNLFFG GPPGALAEEL YPGGGGGDDD CSDDIW---- -DDDREGVMM MLIIDVDVVL LKLLPNLFFG GPPGALAEEI YPGGGGGDDD CSDDIW---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -DDDKEGVMM MLIIDVDEEL LKLLPNLFFG GPPGVLAEEL YPGGGGGDDD CSDDIW---- -DDDKEGVMM MLIIDVDKKL LKLLPNLFFG GPPGVLAEEI YPGGGGGDDD CSDDIW---- -GGGEKGHII ILIIDVDEEL LKIIPNFFFG GPPGALAEEM YPGGGGGDDD CSDDIW---- -KKKEQGHII ILIIDVDEEL LKIIPNFFFG GPPGSLAEEM YPGGGGGDDD CSDDIW---- -EEEDKGHII IIIIDVDEEL LSIIPNFFFG GPPGALAEEM YPGGGGGDDD CSDDIW---- -EEEEKGHII IIIIDGDEEL LTIIPDFFFG GPPGSLAEEM YPGGGGGDDD CSDDIW---- GDDDKKGHMM MLIIDVDEEL LSIIPNFFFG GPPGSLAEEM YPGGGGGDDD CSDDIW---- -EEEKSGTMM MVVVNIDEEM MEIIRDLFFG GEEGYLAEEM YPGGGGGDDD CSDDIW---- -EEERSGTMM MLIIDVDIIM MVIIKNLFFG GPPGYLAEEM YPGGGGGDDD CSDDIW---- -NNNKEGVMM MLIIDVDEEL LTVVKNLFFG GPPGCLADDI FPCCCGGDDD SSDDIL---- -EEEAAGTII IVLLDIDEEM MKLLENLFFG GPPGGLPEEM ---------- ---------- -KKKSQGHII IVIIDVDVVI ISLLEDLFFA APPGSLPEEM YPGGGGGDDD CSDDIWAA-- ---------- ---------- ---------- ---------- ---------- ---------- ----KKGDDD DAYYLKANNK KELLEDAFFY YGGG-RAIIM FGSSSSSAAA LSSS------ ----KKGDDD DEFFLKLYYK KELLEQAFFY YKKG-RPQQM FGAAARRAAA LAGGPARRLL ------- ------- RRRR--- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- VVVVRVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSSSAAKKKK PSSETTTPPP RRVVVTTGGG LTARDGGGAA AQQSSAALLL LLLTPGGSPV gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRIKAYQEAA WTSSSAIIQQ QQVLLLAPRR ESRTSSSVLL LLLLVVVEII SSVKVVVPQA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MAGRR APLLLPLLNN NNNRRRTPHH NPPSPPPHVV VVVVPPPLTT RRRYTTINPR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MIIVPPF KRRDDFYPSS SSKMAAMKPP PDDCCYTGGT ---------- ---------- ----MMAKKL KPPDDFYPTT TTRDAAMRPP PDDAAYVGGT ---------- ---------- ------MSSM RPPDDFHASS SSELAAMQPP PEELLSPDDF ---------- ---------- ------MTTM RPPDDFHASS SSKLAAMEPP PNNLLSPDDF ---------- ---------- ------MTTL RPPDDFYPSS SSKLAAMEPP PKKMMSPDDA ---------- ---------- ----MMATTW KPPDDFYPSS SSRLAAAKPP PTTMMDPEER ---------- ---------- ----MMVTTW RPPDDFYPSS SSRMAAVKPP PKKRRNPMMA ---------- ---------- ----MMASSW RPPDDFYPSS SSKMAAMQPP PRRLLDPGGR ---------- ---------- --MTCCTKK- -CCGGYPTPP PPEAMMK-PP PEECCYRNNT ---------- ---------- ---------- ---------- ------M-PP PEECCYRNNT AQQAAHWLPP GHGVIAPPPG -AHTCCGKK- -CCGGYPSPP PPEAMMK-PP PEECCYGNNT ---------- ---------- ---------- ---------- ----MMK-PP PEECCYRNNT ---------- ---------- --MTCCGNN- -CCGGYSTPP PPEAMMK-PP PEECCYRNNT --------AE REGTQSPPPI ASTTCCGNN- -CCGGYSTPP PPEAMMK-PP PEECCYRNNT ---------- ---------- --MTCCGNN- -CCGGYSTPP PPEAMMK--- ---------- ---------- ---------- --MTCCGNN- -CCGGYSTPP PPEAMMK-PP PEECCYRNNT -----MGLGK EPGAPWWWWQ EDTTCCGDD- -CCGGYPTPP PPEAMMK-PP PEECCYRNNT ---LLKNSQG CGFTTELLLV FTSTCCGNN- -CCGGYSTPP PPEAMMK-PP PEECCYRNNT ---------- ---------- --MTCCGNN- -CCGGYSTPP PPEAMMK-PP PEECCYRNNT RPPPPPHARH SVLIEGAAAA AANKCCCHHT AKKGGYATPP PPEAMMEKPP PKKCCYNGGT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---ACCGSS- -CCGGYKSPP PPDAMMK-PP PEECCYRSST ---------- ----ATVVVN EKK-NNGCCC KSSGGYASPP PPESMMS-PP PSSAAYAGGT ---------- ----GTVVVS EKVNQQGCCC KSSGGYASPP PPEAMMS-PP PTTAAYAGGT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----RRMLLQ VGGGGYATPP PPAAMMS-PP PKKAAYTGGT ---------- ------AAAA AANACCCGGG ATTGGYATPP PPEAMMEKPP PKKCCYNGGT ---------- ------MMMS PNCLCCHGG- ---GGYASPP PPDAIIK-PP PEEAA----N ---------- ------MMMP --CLCCHGG- ---GGYASPP PPDAIIK-PP PEEAA----H ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MEESKKC KCCGGYATPP PPDAVVRNPP PKKCCQPNNL ---------- ---------- ---------- ---------- ----MMRSPP PKKTTQPNNL ---------- ---------- ---------- ---MMLIT-- --DILLISDD DFFWWHGDDI -------MKR RFG---AAAG -ALMLLPFFR AFFAATCQSS SSYMPPKIGG GEETTGVEEG -------MKR FVSSHFSSSG LALLAAPAAG VRRAATCASS SSYMKKKIGG GDDTTGAEEG TGGGGINNRR RRADDDDFVV VVVVVNPETS KVHKKVLLPI IIINDDELFG GGNACSSSSS TGGGGVNNAA AAPDDDDFVV VVVVVDPPTG KIYKKLLLPI IIIGDDELFG GGNACSSSSS FSSSS---RR RRPDDDDAVV IIIIVKPSTG KVHTTVMMPT TTTGDDEFFG GGNACSSSSS FSSSS---KK KKPDDDDAVV IIIIVKPPTG QVHTTVMMPK KKKGDDEFFG GGNACSSSSS ASSSS---KK KKPDDDDGVV VVVVVDPEKG QVHQQLMMPK KKKGDDEFFG GGNACSSSSS RKKKK---QQ QQPDDDDAVV VVVVVDPPRA SVGQQVMMPA AAAGDDELFG GGNACSSSSS ANNNNG--KK KKPDDDDAVV VVVVVDSSTG QVGVVTMMPT TTTGGGELFG GGNACSSSSS REEEE---RR RRPDDDDAVV LLLLLDPGTA QVGRRVMMPA AAAADDELFG GGNACSSSSA TGGGGTEEAA AAPDDDDYTT VVVVVDPPQS QIHRRLMMPL LLLKDDELSG GGNTCSSSSS TGGGGIEEAA AAPDDDDYTT VVVVVDPPHS QIHRRLMMPL LLLKDDELSG GGNTCSSSSS TGGGGIEEAA AAPDDDDYTT VVVVIDPPQC QIHRRLMMPL LLLRDDELSG GGNACSSSSS TGGGGIEEAA AAPDDDDYTT VVVVVDPPQC QIHRRLMMPL LLLKDDELSG GGNTCSSSSS TGGGGTEEAA AAPDDDDYTT VVVVVDPPQC QIHRRLMMPL LLLKDDELSG GGNTCSSSSS TGGGGTEEAA AAPDDDDYTT VVVVVDPPQC QIE------- ---------- ---------- -----TEEAA AAPDDDDYTT VVVVVDPPQC QIHRRLMMPL LLLKDDELSG GGNTCSSSSS TGGGGTEEAA AAPDDDDYTT VVVVVDPPQC QIHRRLMMPL LLLKDDELSG GGNTCSSSSS TGGGGTEEAA AAPDDDDYTT VVVVVDPPQS QIHRRLMMPL LLLKDDELSG GGNTCSSSSS TGGGGTEEAA AAPDDDDYTT VVVVVDPPQC QIHRRLMMPL LLLKDDELSG GGNTCSSSSS TGGGGTEEAA AAPDDDDYTT VVVVVDPPQC QIHRRLMMPL LLLKDDELSG GGNTCSSSSS TGGGGINNKK KKLDDDDYTT VVVVLDPPTS QIHRRLVVII IIIGDDKLSG GGNSCSSSSS ---------- ---------- ---------- ------MMPT TTTNDDELSG GGNTCSSSSS TGGGGINNKK KKPDDDDYTT VVVVVDPPSS QIHRRLMMPV VVVNDDELSG GGNTCSSSSS TGGGGIEEKK KKPDDDDYTT VVVVVDPPTS KIHRRLVVPV VVVGDDELTG GGNSCSSSSS TGGGGIEEKK KKPDDDDYTT VVVVLDPPTS KIHRRLVVPV VVVGDDELTG GGNSCSSSSS ---------- ---------- ---------- ------MMPV VVVGDDELSG GGNSCSSSSS TGGGGIDDKK KKPDDDDYTT VVVVVDPPSS SIHRRLMMPV VVVGDDELSG GGNSCSSSSS TGGGGINNKK KKPDDDDYTT VVVVVDPPTS QIHRRLVVTV VVVGDDELSG GGNACSSSSS NAAAAADDGG GGPDDDDATT VVVVVNPDTC QISRRVVVPI IIIGDDEVTG GGNACSSSSS HAAAARDDGG GGPDDDDATT VVVVVNPETC QISRRVVVPI IIIGDDEVTG GGNACSSSSS ---------- ---------- ---------- ---------- ---------- ---------- LDDDDEEEHH HHGDDDDYTT VVVVVDPPTC QIHRRTTTNK KKKHNNELSG GGNTCSSSSS LDDDDEPPHH HHGDDDDYTT VVVVVDPPTC QVHRRTTTNK KKKGDDELSG GGNACSSSSS IRRRRQYYDD DDITTTTDNN PPPPMVGFLG SLKDDGVVKL LLLEDDKESQ QQTPRIIIIL GMMMMGDDEE EEQDDDDKTT IIIILRPATG QINSSVVVG- ---RNNEAGG GGSA------ GVVVVGDDEE EEQDDDDKTT VVVVANPPQG KVNTTLVVG- ---RNNEASD DDTD------ ALCCC----P NGGPNERLII IGGLLRRSSI IDTTTKKKPN NNPRRKKIPE EEEVVVKKKV AYCCC----P NAAPFERLII IAALLRRSSI IDTTTKKKPD DDKRRAAVPE VVVAAAVVGR SLSSS----P LTTAFERLII IGGLLRRSSV VDTTTKKKPH HHPTTRRIPD EEEIIILLAK ALSSS----P LAAAFERLII IGGLLRRSSI IDTTTKKKPD DDPTTKKIPE EEEVVVFFKK ALSSS----P LTTAFERLII IGGIIRRSSI IDVVVKKK-E EEPLLKKIPE EEEVVVFFAK CLCCC----P NAAPHERLVV VGGLLRRSSI IDTTTKKKPD DDPLLFFIPE TTTLLLAAER MLCCC----P NAAPHERLVV VDDIIRRSSI IDTTTKKKPD DDPTTKKIPN EEELLLAAER ALCCC----P YAAPHERLII IGGIIRRSSI IDTTTKKKPD DDPRRRRIPE EEELLLHHRR C--------- -FFSTSRLII IGGLLMMSSV VDVVVGGGSE EEPRRKKIAS EEEIIIQQAK C--------- -FFSTSRLII ISSIIIISSV VDVVVGGGSE EEPRRKKIPN EEEIIIHHAK C--------- -FFSTSRLMM MCCLLMMSSV VDVVVGGGSD DDPRRKKIAE DDDIIIHHAK C--------- -YYITARLVV VAALLIISSV VDVVVGGGTE EEPRRKKIPK DDDIIIHHTK C--------- -FFSTSRLVV VSSLLIISSV VDVVVGGGSE EEPRRKKIPE DDDIIIHHAK ---------- ---------- ---------- ---------- --------PK DDDIIIHHAK C--------- -FFSTSRLVV VSSLLIISSV VDVVVGGGSE EEPRRKKIPK DDDIIIHHAK C--------- -FFSTSRLVV VSSLLIISSV VDVVVGGGSE EEPRRKKIPK DDDIIIHHAK C--------- -FFSTSRLVV VSSFFIISSV VDVVVGGGTE EEPRRKKIAK DDDIIIHHEK C--------- -FFSTSRLVV VSSLL----- ---------- ---------- ---------- C--------- -FFSTSRLVV VSSLLIISSV VDVVVGGGSE EEPRRKKIPK DDDIIIHHAK C--------- -HHPSKRLII ISSLLLLGGV VDTTTAAATD DDPRRSSVSE DDDIIIAAEN C--------- -YYASVRLII ICCLLIISSV VDVVVGGGTD DDPRRRRVPY EEEVVVFFWK C--------- -YYSSVRLII ICCLLIISSV VDVVVGGGSD DDPRRRRVPY EEEVVVFFWK C--------- -HHPSERLII ISSLLVVGGV VDTTTKKKTN NNPRRSSVPA DDDIIIIIQK C--------- -HHPSQRLII IGGIIVVGGV VDTTTKKKTN NNPRRSSVPE DDDIIISSTK C--------- -HHASDRLVV VSSLLIIGGA ADTTTKKKEN NNPRRSSVPK EEEIIIAAEK C--------- -HHASDRLVV VSSLLIIGGA ADTTTKKKEN NNPRRSSVPK EEEIIIAADK C--------- -HHPSSRLII ISSLLLLGGV VDTTTLLLKD DDPRRAAVAE DDDIIIAAEK C--------- -HHPTKRLII ICCLLNNDDI INVVVEEENE EE-RRYYIPS KKKLLLHHSL C--------- -HHPTKRLII ICCLLNNDDV VNVVVEEENE EE-RRYYIPS KKKLLLHHAL ---------- -------MVV VKKLLSSGGK KFVVVGGGG- ---------- ---------- CHFFFVVVVP -GGEVTRLVV VCCLLNNDDV VDTTTGGGTD DDPRRKKIG- DDDVVVLLKG CYYYYVVVVD ESSTVKRLVV VSSLLNNDDI IDVVVVVVTD DDPRREEIG- DDDVVVLLKS K--------- ---RVGGMLL LSSLLDDKKV VTSSSLLLYS SSAWWQQ--- DDDLLLIIKF ---------- -----DRFWW WGGLLDDNNI IDVVVHHHSD DDPSSKKIT- FFFVVVKKDS ---------- -----DRLWW WGGLLDDSSV VDVVVHHHSD DDPAAVVID- FFFVVVEEKS SGGGYSLLHT HGGGPPPDDA AIYISLGNNN N--GPGMLDY SEPKWEEERG QYY------- TGGGYTYYHT HGGGPPPDDA AIYISLGGGG G--GPGLLDD TEPRWEEERG QYY------- TGGGYSPPHT HGGGPPPEEG GIYVSLGGGG GGKGAGIMDE TDVRWEEERG QDD------- TGGGYSPPHT HGGGPPPDDG GIYVSLGGGG GGKGPGIMDE TEVRWEEERG QTT------- TGGGYSPPHT HGGGPPPEEG GIYVSLGGGG GGEGPGILDE TEIRYEEERG QTT------- TGGGYSPPHT HGGGPPPGGG GIYVTLGNNN N--GPGMLDQ SEPRWEEERG QYY------- TGGGYAPPHT HGGGPPPDDG GIYISLGSSS S--GPGILDD NEVRWEEERG QYY------- TGGGYSPPHT HGGGPPPDDG GVYVSLGSSS S--GPGVMDE SDPRWEEERG QQQ------- CNNNVSTTHT HLLLAAASSG GEVMVTLGGG G--GKSLLDE TEVTWEEEGG SPP------- CNNNLGLLHT HLLLAAASSG GEVMISLGGG G--GKGLLDE TEVTWEEEGG APP------- CGGGLGVVHT HLLLAAASSG GEVMITLGGG G--GKGLLDE TEVTWEEEGG APP------- CNNNLGFFHT HLLLPPPSSG GEVMVTLGGG G--GKGLLDK TEVTWEEEGG APP------- CEEELALLHT HLLLAAASSG GEVMISLGGG G--GKGLLDE TEVTWEEEGG APP------- CEEELALLHT HLLLAAASSG GEVMISLGGG G--GKGLLDE TEVTWEEEGG APP------- CEEELALLHT HLLLAAASSG GEVMISLGGG G--GKGLLDE TEVTWEEEGG APP------- CEEELALLHT HLLLAAASSG GEVMISLGGG G--GKGLLDE TEVTWEEEGG APP------- CGGGLGPPHT HLLLPPPTTG GEVMITLGGG G--GKGLLDE TEVTWEEEGG APP------- ---------- ---------- ---------- ---------- ---------- ---------- CEEELALLHT HLLLAAASSG GEVMISLGGG G--GKGVLL- REC------- ---------- IGGGLGPPHT HLLLAAASSG GDIMICLGGG G--AANLLLS ENVRGSSSLF ISS------- CGGGLALLHT HLLLGGGCCG GEIMISIGGG G--GKGLLDE TEVNWEEEGE APP------- CGGGLAPPHT HLLLGGGCCG GEIMISLGGG G--GKGLLDE TEVNWEEEGE AQQ------- TGGGLAPPHT HLLLAAASSG GELMICLGGG G--AENLLLS DNVRWEEEGH PLL------- TGGGLAPPHT HLLLAAASSG GEIMICIGGG G--AENLLLS ENVRWEEEGH PLL------- TGGGLAPPHT HLLLAAASSG GEILVCLGGG G--AKNLLLS DNIRWEEEGH PLL------- TGGGLAPPHT HRRRTTT--G GEILVCLGGG G--AKNLLLS DNIRWEEEDI PLL------- TGGGLGPPHT HLLLAAASSG GEIMICLGGG G--AANLLLS ENVRWEEEGH PLL------- N---LSPPHT HLLLAAADDG GNIMITLGGG G--PSNLLDK TEPTWPPPEK VPP------- N---LSPPHT HLLLAAADDG GNIMITLGGG G--PSNLLDK TEPTWPPPGK VPP------- ---------- ---------- ---------- ---------- ---------- ---------- ADDDCTPPHT HLLLPPPNNG GNIMIIMGGG G--AK-VEFK NELTWSSSDR ALL------- HNNNVTPPHT HLLLAAANNG GNIMIVMGGG G--AK-ILFS DNCTWTTTDK ALL------- LVVVLASSHT DQQQPPPNNT TALKQGVNNN N--PVNQTSH EGLKGEEEQF EII------- GGGGVVPPHT FLLLPPPGGS SMMITLSNNN N--GRAEYND GYVYWMMMAD MQQGVVVAAD GGGGVVPPHT YLLLPPPGGR RMLITLSNNN N--GRAEYTA GYVHWIIIDG LRRGITTKAD -LYYDDWWWW -NNEVLVSSS EWVNTTTIIE DDGLKKLLEH HLRYNNNNRI HLRKKIHLLG -FYYDDWWWW -SSGVMITSS EWVRCCCFFE EEGFSSLLEC CLAYNNNNKL HLAKRLYILG -KYYDDWWWW -RRDYMVSSS EWLPQQQFFE NNGIVVPPED DLKYHHHHRL HLRARVQILG -LYYDDWWWW -RRDYMVTSS EWLPQQQFFE NNGIVVPPED DLKYHHHHRL HLRARVQILG -KYYDDWWWW -RRDYMVSSS EWLPQQQFFE NNGIVVPPED DLKYHHHHKI HLRDKVQILG -FYYDDWWWW -YYDTLVTSS EWTDMMMVVE DDGLVVPPDI ILRYRRRRRL HLTRRLQIFG -LYYDDWWWW -YYDTLLTSS EWTRMMMVVE SSGVLLGGDE ELKYHHHHRL HLYRRLQLLG -LYYDDWWWW -YYDTMVTSS EWTNMMMIIE GGGLDDPPQI ILGYRRRRRL HLRRRLQLVG -MYYDDWWWY -HHNVMVSTT EWANVVVFFK DDGNPPAAHV VELYSSSSRI FWQREIQLMT -MYYDDWWWY -HHNIMVSTT EWANVVVFFK DDGNPPAAHV VELYSSSSHI HWQREIQLMK -MYYDDWWWY -HHNVMISTT EWANVVVFFR DDGNPPAADV VELYSSSSHL HWQREIQLLQ -LYYDDWWWY -HHNVMISTT EWANVVVLLR DDGNPPAADV VKLYSSSSHL YWQREVQLLQ -SYYDDWWWY -HHNVMISTT EWANVVVLLR DDGNPPAADV VELYSSSSHL YWQHEVQLLK -LYYDDWWWY -HHNVMISTT EWANVVVLLR DDGNPPAADV VELYSSSSHL YWQREVQLLK -LYYDDWWWY -HHNVMISTT EWANVVVLLR DDGNPPAADV VELYSSSSHL YWQREVQLLK -LYYDDWWWY -HHNVMISTT EWANVVVLLR DDGNPPAADV VELYSSSSHL YWQREVQLLK -MYYDDWWWY -HHNVMISTT EWANVVVVVQ NNGNPPAADV VELYKKKKHL HWQREVQLMP ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AA ISHNLLLRRL TTGRDDYYPA ASRVGGGGIT ---------- -KRRTTLLLY YWWGLFWSWW IQCLFFFYYT TTGELLMMCL LTGVVVVVIS CYIMVDELLQ -FYYDDWWWY -HHNVMISTT EWAKAAAFFA LLGKMMEEEV VQMYHHHHSL NWTERIQILG -FYYDDWWWY -HHNVMISTT EWAKAAAFFA LLGKMMEEDV VQHYHHHHSL NWTERVQILG -FYYDDWWWY -HHNTMISTT SWATAAAFFT KKGDLLQQHV VALYRRRRHL TLARERQLLG -FYYDDWWWY -HHNTMISTT SWAKAAAFFL QQGNLLQQHV VALYRRRRHL HWPGEKQLLG -FYYDDWWWY -HHKTMISTT SWAKAAAFFS KKGDLLQQHV VALYSSSSHL HWPGEKQILG -YYYHHWWWY -HHKTMISTT SWAKAAAFFS KKGNLLQQHV VALYSSSSHL HWPGEKQILG -FYYDDWWWY -HHKTMISSS SWAAAAAFFR TTGDLLQQHV VQLYRRRRHL HWPGEKQLLG -FYYDDWWWY -RRNVMISTT EWSNHHHIIK KKGNPPAAHV VGLYNNNNSV HWDSKLQILP -FYYDDWWWY -RRNIMISTT EWSNHHHIIK KKGNPPAAHV VPLYNNNNSV HWDTKLQILP ---------- -------SII LRGVTTTVVC RRDELLKKCQ QPLVKKKKCK R--------- -CYYDDWWWY -FFNVMVASS EWAKLLLFFR RRGHPPTTDC CDQYCCCCRL NWQEEFQILG -CYYDDWWWY -FFDVMVSSS EWANKKKWWR RRGKNNVVDL LEQYCCCCRL NWSTTYQILG -LLLSSHHHN -RREKSESDD RPEIMMMAAF EESESSFFLK KKLKQQQQHV A--------- DYYYDDRRRA -KKNVMLTSS SFGSMMMMMD FFGMLLQQDA AERFNNNNTI VLHTQKKFVP DYYYDDRRRA -KKNLLVTSS SFGNMMMMMD FFGMLLAADP PEHFNNNNTV VLHTQKKFVP ERMAAAL--- -----LRPTT TKKMGFINNN SLKKSSSWLY YEGKKKNAEV IIPAEEE--L QRMVVVL--- -----VRPTT TKKMGFVNNN NTKKSSSWLY YEGKKKQAEV IIEAQEE--L AQMAAAL--- -----VRPVV VRRYGFVGGG DTTTEEEWTR REGKKKHVKT AAPAETTDDL AQMAAAL--- -----VRPVV VRRYGFVGGG DTTTEEEWTR REGKKKHAET AAPPEPPEEL AQMAAAL--- -----IRPSS SKKYGFCGGG DTTTQQQFTQ QDGTTTEAKT IIDPVDDDDL DQLVVVF--- -----LRPTT TKKYGFVNNN SLKKSSSWTR RDDKKKAVRV IIPAEDDDDL AQMAAAL--- -----LRPTT TKKYGFMNNN SLKKSSSWLR RDGSSSHLKV IIPAESSDDL EQMVVVL--- -----LRPAA ARRYGFVGGG SLEESSSWLR RQGSSSGIRV IIPAEEEDDL -GLIIIP--- ----LIRFSS SAAQGFVGGG SSNNRRRNE- ---------- TTVEKQQPPK -GLIIIP--- ----LIRFDD DAAQGFVGGG SSNNRRRNE- ---------- TTVEKQQPPK -GLIIIP--- ----LIRFDD DAAQGFVGGG SSTTRRRNQ- ---------- TTVEKQQPPK -GLIIIP--- ----LIRFDD DAAQGFVGGG SSTTRRRNE- ---------- TTAQKQQPPK -GLIIIP--- ----LIRFDD DAAQGFVGGG SSTTRRRNE- ---------- TTVEKQQPPK -GLIIIP--- ----LIRFDD DAAQGFVGGG SSTTRRRNE- ---------- TTVEKQQPPK -GLIIIP--- ----LIRFDD DAAQGFVGGG SSTTRRRNE- ---------- TTVEKQQPPK -GLIIIP--- ----LIRFDD DAAQGFVGGG SSTTRRRNE- ---------- TTVEKQQPPK -GHIIIP--- ----LIRFAA AAAQGFVGGG SSTTRRRNE- ---------- TTVEKEEPPK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -QAGGGANNN NPIILLRSNN NIIQDYDVVV SFSSGGGPD- ---------- AALKRDDYYA EGLIIIP--- ----LIRFDD DAAQGLVGGG SSTTRRREK- ---------- KKAEKKKPPK KGLIIIP--- ----LIRFDD DAAQGLVGGG SSSSRRREK- ---------- KKAEKQQPPK NGLLLLP--- ----LIRFAA AKKTGFVGGG SSNNRRRTQ- ---------- SSHELPPKKL DGLLLLP--- ----LIRFAA AKKTGFVGGG TSNNRRRTQ- ---------- SSHEISSEEL EGLLLLP--- ----LIRFSS SKKTGYVGGG SSNNRRRNS- ---------- TTYEISSKKL PGLLLLP--- ----LIRFSS SKKTGFVGGG SSNNRRRNS- ---------- TTHEVSSKKL SGLLLLP--- ----LVRFSS SKKTGYVGGG TSNNRRRTA- ---------- SSHEVSSKKL QGALLLP--- ----LVRFTT TSSHAFVGGG GSGGRRRVES S--------- TTATLFFPPK MGALLLP--- ----LVRFTT TSSHAFVGGG GSAARRRDEP P--------- VVASLTTPPK ---------- ---------- ---------- ---------- ---------- ---------- DGLTTTP--- ----LIRFRR REEQGYVGGG XXXXXXX--- ---------- ---------- SGITTTP--- ----LIRFKK KKKEGFVGGG NAKKHHHKSD D--------F EEKVIPPKKV ---------- ---------- ---------- ---------- ---------- ---------- G--------- ----LIRFNN NAAYAFSTTT TSQQLLLDD- ---------- -----EEQQK G--------- ----LIRCAA AHHYCFTSSS TSQQLLLDG- ---------- -----EEQQK PEELLKAAAP LTIIILLDFF LLLSLLWIGG EERQDDISNF FVTTGVVLGG GGGGGGFRAD PPPLLKMMMP LTIIILLDFF LVVSLLWLGG EERQDDITNH HRAAGVVIGG GGGGGGYREP PPPLLGAAAP LTILLLLDFF LVVSCCWTGG EERQDDVSDH HVAAGVVIGG GGGGGGARAP PPPLLGAAAP LTILLMMDFF LVVSCCWTGG EERQDDVSDR RKAAGVVIGG GGGGGGARTP PDDLLGAAAP LTILLLLDYY LVVACCWLGG EEHQDDVSDM MVTTGVVIGG GGGGGGVKTP PPPLLKAAAP LTILLMMDFF LVVSCCWTGG DDLQDDVSDF FKTTGVVIGG GGGGGGVRAT PPPLLKAAAP LTILLVVDFF LVVSCCWTGG EEHQDDVSDF FRTTGVVIGG GGGGGGVRAG PPPLLGAAAP LTILLLLDFF LVVSCCWTGG EERQDDVSDF FRTTGVVLGG GGGGGGVKAA KVVGGPEEEG LTILLLLDFF LFFSNNWHGG DDRQDDISNQ QRTTGIILGG GGGGGGIRGG KVVGGPEEEG LTILLLLDFF LFFSNNWHGG DDRQDDISNK KRTTGIILGG GGGGGGIKGG KVVGGPEEEG LTILLLLDFF LFFSNNWHGG DDRQDDISDQ QRTTGLLLGG GGGGGGIKGG KVVGGPEEEG LTILLLLDFF LFFSNNWHGG DDRQDDVSDQ QRTTGLLLGG GGGGGGIKDG KVVGGPEEEG LTILLLLDFF LFFSNNWHGG DDRQDDISDQ QRTTGLLLGG GGGGGGIKGG KVVGGPEEEG LTILLLLDFF LFFSNNWHGG DDRQDDISDQ QR-------- ---------- KVVGGPEEEG LT-------- ---------- ---------- ---------- ---------- KVVGGPEEEG LTILLLLDFF LFFSNNWHGG DDRQDDISDQ QRTTGLLLGG GGGGGGIKGG KVVGGPEEEG LTILLLLDFF LFFNNNWHGG DDRQDDISDK KRVVGIILGG GGGGGGIKGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVKKVSSSN EPAIIFFDLL IFFLSS---- ---------- ---------- ---------- KVVGGPEEEG LTIIILLDFF LFFSNNWHGG DDRQDDITDR RKVVGIILGG GGGGGGIRGG KVVGGPEEEG LTIIILLDFF LFFSNNWHGG DDRQDDITDR RKVVGIILGG GGGGGGIRGG KVVNNPEEEG LTFIILLDFF LFFVNNWHGG DDRQNNIEDK KVTTGLLVGG GGGGGGIKGS KVVNNPEEEG LTFIILLDFF LFFVNNWHGG DDRQNNIEDK KKTTGVVAGG GGGGGGIKGS KVVNNPEEEG LTFIILLDFF LFFVNNWHGG DDRQNNIEDK KVTTGIIVGG GGGGGGLKGS KVVNNPEEEG LTFIILLDFF IFFVNNWHGG DDRQNNIEDK KVTTGIIVGG GGGGGGLKGS KVVNNPEEEG LTFIILLDYY LLLVNNWHGG DDRQNNIEDA AVAAGVVAGG GGGGGGLKGS KVVGGPEEEA LTIIIMMDFF LVVSCCWHGG DDRQDDISDL LKNNSVVIGG GGGGGGVTES KVVNNPDDDA LTIIIMMDFF LVVSCCWHGG DDRQDDISDK KKNNSVVIGG GGGGGGISET ---------- ---------- ---------- ---------- ---------- ---------- QGGNNEMMMG MTIIILLDYY LFFSNNWHGG DDRQDDISDA ARTTGVVLGG GGGGGGIRDA DTTSSEDDDG MSIIILLDFF LVVNCCWHGG DDRQDDITDE EKTTGLLLGG GGGGGGISDL ---------- ---------- ---------- ---------- ---------- ---------- AVVDDPAAAP LVIIIAADTT LIINSSFDGG KKRLDDISDH HFIIYKKIDD DDRRRRV--- AVVDDPAAAP LVIIINNDRR LVVNTTFDGG KKRLDDISDH HRVVYKKIGG GGAAAAV--- DDHPP----- ---------- --KLGGGQMM MLLSDRVYYT NNSSLSSTTW DDDNQFYYYY PPHPP----- ---------- --EAGGGQMM MIISDRVYYT NNSSLSSSSW NNNNQFYYYY PPHPP----- ---------- --TFGGGQMM MVVSDRVYYT NNSSLSSTTW DDDDQFYYYY PPHPP----- ---------- --AFAAAQMM MVVSDRVYYT NNSSLSSTTW DDDDQFYYYY PPHPP----- ---------- --TFYYYQMM MVVSDKVYYT NNSSLSSTTW DDDEQFYYYY TTHPPG---- ---------- -AALGGGQMM MVVSDRVYYT NNSSLGGAAV DDDPQFYYYY GGHPP----- ---------- -AELGGGQMM MVVSDRVYYT NNSSLRRAAW DDDEQFYYYY AAHPP----- ---------- --PLGGGQMM MVVSDRVYYS NNSSLAASSW DDDEQFYYYY GGSVVQEDQL LLTTTQPPPP LVRIGGGQMM MIISDKLYYT TTSSLSSDDW DDDKQFYYYY GGSVVQEDQL LLTTTQPPPP LVRVGGGQMM MIISDKLYYT TTSSLSSAAW DDDKQFYYYY GGPVVQEDQL LLKKKQPPPP LVKVGGGQMM MIISDKLYYT TTSSLSSAAW DDDKQFYYYY GGPVVQDDQL LLDDDQPPPP LVQVGGGQMM MIISDKLYYT TTSSLSSAAW DDDKQFYYYY GGPVVQEDQL LLKKKQPPPP LVRVGGGQMM MIISDKLYYT TTSSLSSAAW DDDKQFYYYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGPVVQEDEL LLKKKQPPPP LVRVGGGQMM MIISDKLYYT TTSSLSSAAW DDDKQFYYYY GGPVVQEDQL LLKKKQPPPP LVRVGGGQMM MIISDKIYYT TTSSLSSDDW DDDKQFYYYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGPVVTEDKL LLEEEQPPPP VVKVGGGQMM MIISDKLYYT NNSSLSSKKW DDDKQFYYYY GGPVVTEDKL LLEEEQPPPP VVIIGGGQMM MIISDKIYYT SSSSLSSIIW DDDKQFYYYY SSPVVAGEDK KKTTTQSSVV PIKLGGGQMM MIITDKLYYT NNSSLSSAAW DDDKQFYYYY SSPVVVKDDE EETTTQSSVV PIKLGGGQMM MIISDKLYYT NNSSLSSAAW DDDKQFYYYY SSPVVKGEDN NNSSSQFFVV PISLGGGQMM MIISDKLYYT NNSSLSSAAW DDDRQFYYYY SSPVVKGEDN NNTTTQFFVV PISLGGGQMM MIISDKLYYT NNSSLSSAAW VVVVSFYYYY SSEVVVTEDK KKEEEQYYVV PVRLGGGQMM MIISDKIYYT NNSSLSSRRW DDDEQFYYYY SSNVVKEGE- -----PIIAA LVKIGGGQMM MLLSDKLYYT TTSSLKKKKW DDDDQFYYYY TTTVVKEEDD DD---EIIAA LVQIGGGQMM MLLSDKLYYS TTSSLKKKKW DDDDQFYYYY ---------- ---------- ----GGGAKK KIISDKLYYT NNSSFSSTTW DDDKQFYYYY AAPRRRNDPL LLKKKAPPPP VLRLGGGQMM MLLSDRLYYS SSSSLSSPPW DDDKQFYYYY LLPNNVKDKL LLKKKRPPAA RVRLGGGQMM MLLSDKLYYS SSSSLSSPPW DDDKQFYYYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM MVVSDKVYYS SSSSLAANNW DDD------- ---------- ---------- --------MM MVVSDQLYYT SSSSLAANNW DDD------- LKGWKLNANN ---PLLLLLE EDKEEFFFVV DFFFG----- --RQQRLGDA SDC------- LRGWKVNVNN ---PLLLLLE EEKEEFFFVV DFFFG----- --RQQRLGDA SDC------- VPAALAHAGG ---PLLLLLT TADDDYWWVV EFFFPGGG-- --RQQRLGDC SDCSSVVVK- VPGVMANVGG ---GLLLLLE EDKDDYFFVV SFFFPGGG-- --RQQRLGDC SDCSSVVV-- RGAAMANVGG ---ELLLLLT TDKDDFWWVV DFFFPGGG-- --RQQRLGDC SDCSSVVV-- IDGWKLDAGG ---PIIIIIE EDPKKFFFLL EWWWPGGG-- --RQQRLGDC SDC------- IKGWKVDVNN ---PMMMMMQ QDPNNFFFVV DFFFG----- --RQQRLGDA SDC------- IRGWKAEADD ---PLLLLLS SDPGGFFFTT EVVVGGGG-- --RQQRLGDS SDCSS----- LIREVMLQVV DDTVLLLLLK KNPNNFLLVV DFFFGEEEPG PPLEERYGDC SDI------- LIREVMLQII DDTALLLLLK KNPNNFLLVV DFFFGEEEPG PPLEERYGDC SDI------- LIREVMLQII DDTVLLLLLK KNPNNFLLVV DFFFGEEEPG PPLEERYGDC SDL------- LIREVMLQII DDTVLLLLLT TNPNNFLLVV DFFFGEEEPG PPLEERYGDC SDL------- LIREVMLQVV DDTVLLLLLK KNPNNFLLVV DFFFGEEEPG PPLEERYGDC SDI------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LIREVMLQVV DDTVLLLLLK KNPNNFLLVV DFFFGEEEPG PPLEERYGDC SDI------- LIREVMLQII DDTVLLLLLK KNPNNFLLVV DFFFGEEEPG PPLEERYGDC TDL------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MIKEVMLQII DDTELLLLLK KNPNNFLLVV DFFFGEEEPG PPLEERYGDC SDV------- LLKEVMLQII DDTKLLLLLK KNPNNFLLVV DFFFGEEEPG PPLEERYGDC TDI------- LVEKHILQII DDTELLLLLK KNPNNFFFVV DFFFGEEEPG PPLEERYGDC TDI------- LVEQHILQII DDTELLLLLK KNPNNFFFVV DFFFGEEEPG PPLEERYGDC TDI------- LMDKHIIQII DDTELLLLLS SNPNNFFFVV DFFFGEEEPG PPLEERYGDC TDI------- IMEKHIIQII DDTELLLLLT TNPDDFFFVV DFFFGEEEPG PPLEERYGDC TDI------- LVKKHMLQII DDTELLLLLS SNPNNFFFVV DFFFGEEEPG PPLEERYGDC TDI------- HVKSTMVQVV NDPEMMMMME ENRDDFLLII DFFFGIIIEG PPLEERYGDC TDI------- NVRSTMLQII DDPIMMMMMV VNKNNFLLII DFFFGVVVPG PPLEERYGDC TDI------- VVKEVMLQII DDTELLLLLT TNKNNFLLVV DFFFGEEEPG PPLDDRFCDS TDA------- MVAATIVQLL DDVEMMMMMK KNENNFLLVV DFFFGEEEPG PPLEER---- ---------- MVSQHIVLII DDTVIIIIIS SNEDDFLLVV DFFFAEEEPG PPLEERYGDC TDLDDAAA-- ---------- ---------- ---------- ---------- ---------- ---------- --KKDDAQYY LAYNKKKKKE EVEDDFAAVV DFFFYLLLGG --RIIRFSAL YS-------- --KKDDEQFF LLYYKKKKKE EKEQQFAAII DFFFYEEEKG --RQQRFAAL YGGNNRRRLQ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QAAAAAE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSAKKAKK QQQPPEEEAA TTPCCRRTTT AAAVPPGTAR AGGAMQSSPT TTQLSSSSLL gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TVAYQEAAWW WTFFFSAAAI VVLLAASPRS SESKKRSVVG GVSSSAAAVA AAKKVPQAAV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MAGRSAA APTTTPPPPL NNRRTTPPHP PNPAAPPHHR RPRRRVVVRP PPYYINPPRL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MAI IPFTSMKAPD LLAYVVCLYT TTTADIIAAA ---------- ---------- ---------M MKLTTMRAPD IIAYVVALYV VTTPDLLAAA ---------- ---------- ---------- -SMTSMQAAE FFAYTTLLSP PFFPDLLAAA ---------- ---------- ---------- -TMTSMEAAN FFAYTTLLSP PFFPDLLAAA ---------- ---------- ---------- -TLTSMEGVK LLAFTTMLSP PAAPDLLAAA ---------- ---------- ---------M MTWSSAKAPT IIAYVVMFDP PRRPDIIAAA ---------- ---------- ---------M MTWTSVKAAK LLAYVVRLNP PAAPDMMCCC ---------- ---------- ---------M MSWTSMQARR LLGYVVLLDP PRRPDLLGGG ---------- ---------- ------ATKC CK-GPK-GRE IIVYLLCIYR RTTPDLLAAA ---------- ---------- ---------- -----M-GRE IIVYLLCIYR RTTPDLLAAA QQQWHLPPPP GGAAAVIAAA AGLPG-STQC CK-GPK-GRE IIVYLLCIYG GTTPDLLAAA ---------- ---------- ---------- -----K-GRE IIIYLLCIYR RTTPDLLAAA ---------- ---------- ------ATKC CN-GPK-GRE IIVYLLCIYR RTTPDLLAAA ------EEEE RRAAATQSSA APRPIAATKC CN-GPK-GRE IIVYLLCIYR RTTPDLLAAA ---------- ---------- ------ATKC CN-GPK-G-- ---------- ---PDLLAAA ---------- ---------- ------ATKC CN-GPK-GRE IIVYLLCIYR RTTPDLLAAA ----MLKKKK EEHHHAPWWL LGLWQEATKC CD-GPK-GRE IIVYLLCIYR RTTPDLLAAA ---LKSGGGG CCDDDTTEEH HYTLVFPTKC CN-GPK-GRE IIVYLLCIYR RTTPDLLAAA ---------- ---------- ------ATKC CN-GPK-GRE IIVYLLCIYR RTTPDLLAAA PPPCPAHHHH SSQQQIEGGA AVTAAAGKTC CHTGPEKGRK LLVYVVCVYN NTTLDLLAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MAKC CS-GPK-GRE IIVYLLCIYR RTTPDLLAAA ---------- ------ATTL LHVVNES-VN NCCGPS-GRS LLIYVVAVYA ATTPDLLAAA ---------- ------GTTL LHVVSENNQQ QCCGPS-GRT LLIYVVAVYA ATTPDLLAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------R RLQGPS-GSK LLIYVVAVYT TTTPDLLAAA ---------- ---------- --MAAAGAAC CGGGPEKGRK LLLYVVCVYN NTTPDLLGGG ---------- ---------- ---MSPGLKC CG-GPK-GRE VVLFVVAP-- -NNPDIIFFF ---------- ---------- ---MP-PLKC CG-GPK-GRE VVLFVVAP-- -HHPDIIFFF ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MSE EKCGPRNGVK LLLYVVCVQP PLLGDLLAAA ---------- ---------- ---------- -----RSGRK LLLYTTTVQP PLLGDLLSSS ---------- ---------- ---------- ---G-ISLDF LLYFSSWLHG GIIITRRKKK -----MRRRR RR-------- -AAAG-AMGL LFRESKITQE FFVYVVTLGV VGGQDLLVVV -----MRRRR FFGGGSHFFL LAVSGLALAA AAGESKITQD YYVYVVTLGA AGGQDLLVVV VVVDVVVVNK SEEYKIKVEE EELLNNDLHH WWWNAACSSS SSSAACCCNN G-KKIIRRFI VVVDVVVVDK SPPYKVKLDD DDLLGGDLHH WWWNAACSSS SSSAACCCNN A-KKLLRRYI VVIDVVVVKG SSSYKITVTT TTMMGGDFHH WWWNAACSSS SSSSSSSSLL TGHHLLRRFI VVIDVVVVKG SPPYQITVTT TTMMGGDFHH WWWNAACSSS SSSAASSSLL AGHHIIRRYI VVVDVVVVDT SEEFQIQLII IIMMGGDFHH WWWNAACSSS SSSAASSSLL TGHHLLRRYI VVVDVVVVDA SPPYSIQVAA AAMMGGDLHH WWWNAACSSS SSSCCCCCNN APHHMMRRYV VVVDVVVVDQ SSSFQVVTDD DDMMGGGLHH WWWNAACSSS SSSMMCCCNN APHHVVRRYV VVLDLLLLDD SGGYQIRVEE EEMMAADLHH WWWNAACSSS AAAAACCCYY APHHVVRRYI TTVDVVVVDK SPPYQVRLPP PPMMKKDLHH WWWNTTCSSS SSSCC----- FGDDKKRNKI TTVDVVVVDK SPPYQVRLPP PPMMKKDLHH WWWNTTCSSS SSSCC----- FGDDKKRDKI TTVDIIIIDK SPPYQVRLPP PPMMRRDLHH WWWNAACSSS SSSCC----- FGDDKKRTKM TTVDVVVVDK SPPYQVRLPP PPMMKKDLHH WWWNTTCSSS SSSCC----- YGDDKKRTKV TTVDVVVVDK SPPYQVRLPP PPMMKKDLHH WWWNTTCSSS SSSCC----- FGDDKKRTKV TTVDVVVVDK SPPYQV---- ---------- ---------- ---------- ---------- TTVDVVVVDK SPPYQVRLPP PPMMKKDLHH WWWNTTCSSS SSSCC----- FGDDKKRTKV TTVDVVVVDK SPPYQVRLPP PPMMKKDLHH WWWNTTCSSS SSSCC----- FGDDKKRTKV TTVDVVVVDK SPPYQVRLPP PPMMKKDLHH WWWNTTCSSS SSSCC----- FGDDKKRNKV TTVDVVVVDK SPPYQVRLPP PPMMKKDLHH WWWNTTCSSS SSSCC----- FGDDKKRTKV TTVDVVVVDK SPPYQVRLPP PPMMKKDLHH WWWNTTCSSS SSSCC----- FGDDKKRTKV TTVDLLLLDS SPPYQVRLPP PPVVGGDLHH WWWNSSCSSS SSSCC----- HGDDAARRFI ---------- ---------- --MMNNDLHH WWWNTTCSSS SSSCC----- YGDDKKRNKI TTVDVVVVDK SPPYQVRLPP PPMMNNDLHH WWWNTTCSSS SSSCC----- YGDDKKRNKI TTVDVVVVDS SPPYKVRLPP PPVVGGDLHH WWWNSSCSSS SSSCC----- HGDDAARRFI TTVDLLLLDN SPPYKVRLPP PPVVGGDLHH WWWNSSCSSS SSSCC----- HGDDAARRFI ---------- ---------- --MMGGDLHH WWWNSSCSSS SSSCC----- HGDDAARRYV TTVDVVVVDS SPPYSVRLPP PPMMGGDLHH WWWNSSCSSS SSSCC----- HGDDVVRRYV TTVDVVVVDN SPPYQVRLPP PPVVGGDLHH WWWNAACSSS SSSCC----- HGDDAARRFI TTVDVVVVNE SDDFQVRVDD DDVVGGDVHH WWWNAACSSS SSSCC----- HDKKEERSHI TTVNVVVVNE SEEFQIRVDD DDVVGGDVHH WWWNAACSSS SSSCC----- HDKKEERSHI ---------- ---------- ---------- ---------- ---------- ---------V TTVDVVVVDA SPPYQVRTYY YYTTHHNLHH WWWNTTCSSS SSSCCFFF-- GGKKPPRDRV TTVDVVVVDE SPPYQIRTFF FFTTGGDLHH WWWNAACSSS SSSCCYYYEE SSKKPPRDRV NNPRMMMMVQ VFFGSVDGPP PPVVEEDELL PPPTPPRIII LLLKK----- -GKKQQGPQL TTIDLLLLRG SAARQVSVSS SSVVRRNAHH FFFSAA---- ---------- ------RRFW TTVDAAAANK SPPYKVTLSS SSVVRRNAHH FFFTDD---- ---------- ------RRYW VLRSSSSSSI YIDTKPPPPP KIEPVVKKVS SGSSLHVCCC GGPIIYANEG --EEEGPGGG VLRSSSSSSI YVDTKPPKKP AVEPAAVGRT TGTTYHVCCC GGPIIYAGDG RREEEGPGGG ILRSSSSSSI YIDTKPPPPA RIEPIILAKT TGSSPHVCCC GGPIIYTGDG TTDDDGAPPP ILRSSSSSSI YIDTKPPPPA KIEPVVFKKT TGSSPHICCC GGPIIYTGDG TTNNNGPPPP IIRSSSSSSI YVDVK--PPA KIEPVVFAKT TGSSPHICCC GGPIIYTGDG TTDDDGPPPP VLRSSSSSSI YLDTKPPPPP FIEPLLAERT TGSSPHVCCC GGPIIYANEG --KKKGPGGG VIRSSSSSSI TLDTKPPPPP KIDPLLAERT TGAAPHVCCC GGPIIYASEG --EEEGPGGG VIRSSSSSSI HVDTKPPPPP RIEPLLHRRT TGSSPHICCC GGPVVYASEG --DDDGPGGG LLMSSSSSSI YVDVGSSPPP KIEAIIQAKC CNSSTHSCCC LLAEEVNGLQ GGNNNGKGGG LIISSSSSSI YVDVGSSPPP KIEPIIHAKC CNGGLHSCCC LLAEEVSGPQ GGNNNGKGGG LLMSSSSSSI YVDVGSSPPP KIEAIIHAKC CGGGVHSCCC LLAEEVSGSK GGNNNGKGGG LLISSSSSSI YVDVGTTPPP KIEPIIHTKC CNGGFHSCCC LLPEEVSGPE GGNNNGKGGG LLISSSSSSI YVDVGSSPPP KIEPIIHAKC CEAALHSCCC LLAEEVSGVK GGNNNGKGGG ---------- ---------- ---PIIHAKC CEAALHSCCC LLAEEVSGVK GGNNNGKGGG LLISSSSSSI YVDVGSSPPP KIEPIIHAKC CEAALHSCCC LLAEEVSGVK GGNNNGKGGG LLISSSSSSI YVDVGSSPPP KIEPIIHAKC CEAALHSCCC LLAEEVSGVK GGNNNGKGGG LFISSSSSSI YVDVGTTPPP KIEAIIHEKC CGGGPHSCCC LLPEEVSGPK GGNNNGKGGG LL-------- ---------- ---------- ---------- ---------- ---------- LLISSSSSSI YVDVGSSPPP KIEPIIHAKC CEAALHSCCC LLAEEVSGVK GGNNNGKDDD LLLSSGGGGV YVDTATTPPP SVESIIAENI IGGGPHSCCC LLADDISGKE GGNNNAAGGG LLISSSSSSI YVDVGTTPPP RVEPVVFWKC CGAALHSCCC LLGEEISGPY GGNNNGKGGG LLISSSSSSI YVDVGSSPPP RVEPVVFWKC CGAAPHSCCC LLGEEISGPC GGNNNGKGGG ALVSSGGGGI YIDTKTTPPP SVDPIIIQKT TGAAPHSCCC LLAEELSGKD GGNNNAEGGG VIVSSGGGGV YIDTKTTPPP SVEPIISTKT TGAAPHSCCC LLAEEISGKD GGNNNAEGGG LLISSGGGGI YIDTKEEPPP SVDPIIAEKT TGAAPHACCC LLAEEISGEE GGNNNAKGGG LLISSGGGGI YIDTKEEPPP SVDPIIADKT TGAAPHACCC RRTEEISGEE GGNNNAKGGG LLLSSGGGGV YVDTLKKPPP AVEAIIAEKT TGGGPHSCCC LLAEEISGKE GGNNNAAGGG VLNSSDDDDI YINVENN--I YIEPLLHSLN N-SSPHSCCC LLANNISGAN GGTTTPSGGG VLNSSDDDDI YINVENN--I YIEPLLHALN N-SSPHSCCC LLANNISGAD GGSSSPSGGG PLSSSGGGGE GVFVGGG--- ---------- ---------- ---------- ---------- LLNSSDDDDI FIDTGTTPPP KIEGVVLKGA ADTTPHTCCC LLPNNISGAE GGNNNAKGGG LLNSSDDDDI YLDVVTTPPP EIDGVVLKSH HNTTPHTCCC LLANNISGAE GGYYYAKGGG QLDGGKKKKL YTTSLYYAAK Q---LLIKFL LVAASHAYYY QQPAALDNSL SSVVVPVLLL TLDTTNNNNI FFDVHSSPPP KIDTVVKDSG GGVVPHFAAA LLPMMMGNDD HHGGGGRTTT ALDTTSSSSI FFDVHSSPPP VITDVVEKSG GGVVPHLAAA LLPMMLGNKD HHGGGGRTTT GIIILLMMMD DDSFEEPLGK KEEIDDRRGG GDQY------ ---------A AYYFFW-PNV GIIIFFLLLD DDTFEEPIGR REEVYYRRGG GPQY------ ---------A AYYFFW-PSV GIIIFFIIID DDTFDDVLGR REEIDDRRGG GPQD------ ---------H HYYFFW-PRY GVVVFFIIID DDTFEEVLGR REEIDDRRGG GPQT------ ---------H HYYFFW-PRY GIIIFFIIID DDTFEEILGR REEMDDRRGG GEQT------ ---------H HYYFFW-PRY GIIIAAMMMD DDSFEEPLGR REEVEERRGG GPQY------ ---------A AYYGGW-GYT GIIIFFIIID DDNLEEVLGR REEIDDRRGG GDQY------ ---------H HYYFFW-GYT GVVVFFVVVD DDSFDDPLGR REEVEERRGG GPQQ------ ---------A AYYFFW-GYT SFFFVVLLLD DDTFEEVKGT TEEKPPGGGG GASP------ ---------G GYYFFW-RHV GFFFVVLLLD DDTFEEVKGT TEEKPPGGGG GEAP------ ---------G GYYFFW-RHI GFFFVVLLLD DDTFEEVKGT TEEQPPGGGG GAAP------ ---------G GYYFFW-RHV GFFFVVLLLD DDTFEEVKGT TEEQPPGGGG GAAP------ ---------G GYYFFW-RHV GFFFVVLLLD DDTFEEVKGT TEERPPGGGG GAAP------ ---------G GYYFFW-RHV GFFFVVLLLD DDTFEEVKGT TEERPPGGGG GAAP------ ---------G GYYFFW-RHV GFFFVVLLLD DDTFEEVKGT TEERPPGGGG GAAP------ ---------G GYYFFW-RHV GFFFVVLLLD DDTFEEVKGT TEERPPGGGG GAAP------ ---------G GYYFFW-RHV GFFFVVLLLD DDTFEEVKGT TEERPPGGGG GSAP------ ---------G GYYFFW-RHV ---------- ---------- ---------- ---------- ---------- ---------- GSSSLLVVVL LLRLEECSG- ---------- ---------- ---------- ---------- NGGGFFLLLL LLEFNNVKGR RSSNRRLLFF FPIS------ ---------E ERRHHLYAWL GFFFVVLLLD DDTFEEVKGN NEEAEEGGEE EAAP------ ---------G GYYFFW-RHV GFFFVVLLLD DDTFEEVKGN NEEVEEGGEE ESAQ------ ---------G GYYFFW-RHV NGGGFFLLLL LLDFNNVKGR REEKPPGGHH HSPL------ ---------G GYYFFW-RHT NGGGFFLLLL LLEFNNVKGR REEKPPGGHH HSPL------ ---------G GYYFFW-RHT NGGGFFLLLL LLDFNNIKNR REEKPPGGHH HSPL------ ---------G GYYFFW-RHT NGGGLLLLLL LLDFNNIKNR REEKPPDDII ISPL------ ---------G GYYFFW-RHT NGGGFFLLLL LLEFNNVKGR REEKPPGGHH HSPL------ ---------G GYYYYW-RHT NFFFLLLLLD DDTFEEPKGT TPPADDEEKK KTVP------ ---------N NYYFFW-RRV NFFFLLLLLD DDTFEEPKGT TPPADDGGKK KVVP------ ---------N NYYFFW-RRI ---------- ---------- ---------- ---------- ---------- ---------- -DDDFFVVVF FFNFEELVGT TSSRGGDDRR RKAL------ ---------G GYYYYW-HFV -DDDFFIIIF FFDFNNCIGT TTTKGGDDKK KKAL------ ---------G GYYFFW-YFV NGGGIIQQQS SSENGGLSAK KEEASSQQFF FEEI------ ---------Q QLLNNH--RK ALLLVVEEEN NNGEYYVATY YMMPTTAADD DDMQAAAAVV GGAAADDGGG GYYIIR-RKV ALLLVVEEET TTGEYYVATH HIIPTTDDGG GDLRAAAAII GGKKADDGGD DYYVVR-RKL LVSWVVVPPP --IDG-LLLE HL--RYGNRR RRFFLLRRRR KRHHLTLGEE EEAAAL---- MITWVVVPPP --FEG-FFLE CLGGAYGNKK KKVVLLAAAR RHYYIDLGQE EEVVVL---- MVSWLLLPPP --FNG-IIPE DLNNKYGHRR RRFFLLRRRR RNQQIDLGAQ QQAAAL---- MVTWLLLPPP --FNG-IIPE DLNNKYGHRR RRFFLLRRRR RNQQIDLGAN NNAAAL---- MVSWLLLPPP --FNG-IIPE DLNNKYGHKK KKFFLLRRRR KNQQIDLGAN NNAAAL---- LVTWTTTPPP --VDG-LLPD ILAARYGRRR RRFFLLTTTR RHQQIDFGDE EEVVVF---- LLTWTTTPPP --VSG-VVGD ELGGKYGHRR RRVVLLYYYR RHQQLDLGAE EEAAAL---- MVTWTTTPPP --IGG-LLPQ ILKKGYGRRR RRIILLRRRR RHQQLDVGEE EEVVVL---- MVSWAAAPPP --FDGFNNAH VEGGLYGSRR RRVVWWQQQH EIQQLQMT-- --IIIP---- MVSWAAAPPP --FDGFNNAH VEGGLYGSHH HHVVWWQQQH EIQQLQMK-- --IIIP---- MISWAAAPPP --FDGFNNAD VEGGLYGSHH HHVVWWQQQH EIQQLTLQ-- --IIIP---- MISWAAAPPP --LDGFNNAD VKGGLYGSHH HHVVWWQQQR EIQQLPLQ-- --IIIP---- MISWAAAPPP --LDGFNNAD VEGGLYGSHH HHVVWWQQQH EIQQLSLK-- --IIIP---- MISWAAAPPP --LDGFNNAD VEGGLYGSHH HHVVWWQQQH EIQQLSLK-- --IIIP---- MISWAAAPPP --LDGFNNAD VEGGLYGSHH HHVVWWQQQH EIQQLSLK-- --IIIP---- MISWAAAPPP --LDGFNNAD VEGGLYGSHH HHVVWWQQQH EIQQLSLK-- --IIIP---- MISWAAAPPP --VNGFNNAD VEGGLYGKHH HHVVWWQQQH EIQQLLMP-- --IIIP---- ---------- ---------- ---------- ---------- ---------- ---------- ---SHHHSSS --RTGSRRYP ASSSRVAGII II-------- ---------- ---------- FWSQCCCSSS --YTGAEEMC LTSSGVHVII IILLYYIIIR VIEELPLQ-- --GGGANNPI MISWAAAPPP --FLGFKKEE VQGGMYGHSS SSVVWWTTTH RRQQIDLGE- --IIIP---- MISWAAAPPP --FLGFKKED VQGGHYGHSS SSVVWWTTTH RLQQIDLGK- --IIIP---- MISWAAAPPP --FKGFDDQH VAGGLYGRHH HHCCLLAAAG ELQQLDLGN- --LLLP---- MISWAAAPPP --FQGFNNQH VAGGLYGRHH HHVVWWPPPG EIQQLDLGD- --LLLP---- MISWAAAPPP --FKGFDDQH VAGGLYGSHH HHVVWWPPPG EMQQIDLGE- --LLLP---- MISWAAAPPP --FKGFNNQH VAGGLYGSHH HHVVWWPPPG EIQQIDLGP- --LLLP---- MISWAAAPPP --FTGFDDQH VQGGLYGRHH HHVVWWPPPG ELQQLDLGS- --LLLP---- MISWSSSPPP --IKGFNNAH VGGGLYGNSS SSIIWWDDDK KYQQIDLPQP PPLLLP---- MISWSSSPPP --IKGFNNAH VPGGLYGNSS SSIIWWDDDK KHQQIDLPMP PPLLLP---- --SRGGGPPP --VRDEEEKC QPPPLVIKCC CCVV------ ---------- ---------- MVAWAAAPPP --FRGYHHTD CDTTQYGCRR RRFFWWQQQR ELQQIDLGD- --TTTP---- MVSWAAAPPP --WRGWKKVD LESSQYGCRR RRFFWWSSSQ TLQQIDLGS- --TTTP---- SESPEEEPPP --AESSEEFL KKPPLKPQHH HHEE------ ---------- ---------- MLTFGGGWWW NNMFGQMMQD AEKKRFGNTT TTQQLLHHHR QPKKFNVPGA AA-------- LVTFGGGWWW NNMFGKMMAD PEKKHFGNTT TTTTLLHHHK QPKKFDVPGA AA-------- ERPPPPPLTL GFIMSSLDDL LSSSIIWFY- DDGWNNAAEE EKKIIIEPG- NNLLPPEIIK ERPPPPPLTL GFVVNNTDDL LSSSIIWFY- DDGWQQAAEE ERRIIIQPG- PPLLPPPVVK ERPPPPPAVE GFVVDDTNNL LEESIIWWR- GGGFHHVVKK KKKAAAEPAD EELLPPPLLG ERPPPPPAVE GFVVDDTNNL LEESIIWWR- GGGFHHAAEE EKKAAAEPKE KKLLPPPLLG ERPPPPPASD GFCVDDTNNL LQQAIIFWQK DDGFEEAAKK KKKIIIVPAD DDLLPPDLLG ERPPPPPATA GFVCSSLDDL LSSSIIWYR- KKDWAAVVRR RKKIIIEAPD QQLLPPPVVK ERPPPPPATA GFMCSSLDDL LSSSIIWYR- NNGWHHLLKK KKKIIIEPED QQLLPPPIIK ERPPPPPAAT GFVVSSLDDL LSSSVVWHR- NNGWGGIIRR RKKIIIEPPD QQLLPPPLLG ERFFFFFLST GFVCSSSIIQ QRRYKKNG-- ---------- ---TTTKVVP SSKKKKVKKP ERFFFFFLDT GFVCSSSIIQ QRRYKKNG-- ---------- ---TTTKVVP SSKKKKVKKP ERFFFFFLDA GFVCSSSIIQ QRRYKKNG-- ---------- ---TTTKVVP PPKKKKVKKP ERFFFFFLDA GFVCSSSIIQ QRRFKKNG-- ---------- ---TTTKVVP PPKKKKVKKP ERFFFFFLDA GFVCSSSIIQ QRRYKKNG-- ---------- ---TTTKVVP PPKKKKVKKP ERFFFFFLDA GFVCSSSIIQ QRRYKKNG-- ---------- ---TTTKVVP PPKKKKVKKP ERFFFFFLDA GFVCSSSIIQ QRRYKKNG-- ---------- ---TTTKVVP PPKKKKVKKP ERFFFFFLDA GFVCSSSIIQ QRRYKKNG-- ---------- ---TTTKVVP PPKKKKVKKP ERFFFFFLAS GFVCSSSIIQ QRRYKKNG-- ---------- ---TTTKVVP PPKKKKVKKP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CRSSSSSINN DYDVSSFGGR RGGSDDPY-- ---------- ---AAARKLY YYAAVVVAAV ERFFFFFLDA GLVCSSSVVF FRRYKKEG-- ---------- ---KKKKVVP SSKKKKVEEP ERFFFFFLDD GLVCSSSIIF FRRYKKEG-- ---------- ---KKKKVVP SSKKKKVEEP ERFFFFFLAD GFVSSSSMMI IRRFKKTG-- ---------- ---SSSLAVK PPLLKKVQQP ERFFFFFLAD GFVSTTSMMI IRRFKKTG-- ---------- ---SSSIVVE PPLLKKVQQP ERFFFFFLSD GYVSSSSMMI IRRFKKND-- ---------- ---TTTIVVK PPLLKKVEEP ERFFFFFLSD GFVSSSSMMI IRRFKKNE-- ---------- ---TTTVVVK PPLLKKVEEP ERFFFFFLSD GYVCTTSMMV VRRFKKTG-- ---------- ---SSSVAIK PPLLKKVRRP ERFFFFFLTE AFVCGGSIIF FRRHPPVNS- ---------- -TTTTTLVIP SSKKKKVSSP ERFFFFFLTE AFVCGGSIIF FRRHPPDNP- ---------- -KKVVVLVIP SSKKKKVEEP ---------- ---------- ---------- ---------- ---------- ---------- ERFFFFFLRN GYVCXXXXXX XXXX------ ---------- ---------- ----QQGEEE ERFFFFFLKA GFVCNNAVVF FHHKKKKSD- ---------- -EEEEEIDGK LLVVDDTGGE ---------- ---------- ---------- ---------- ---------- ---------- ERFFFFFPNN AFSTTTSLLW WLLYEEDG-- ---------- --------WQ AAKKAAVAAP ERCCCCCAAN CFTTTTSLLW WLLYEEDG-- ---------- --------WQ AAKKAAVAAP PPPPLVTTDD ISSDDDKKFL LYLGIIGYII SNPPVTKKVV KKGFRADHPP P--------- PPPPLVTTDD ISSDDDRRFL LYVGLLGYII TNPPRARRVV KKGYREPHPP P--------- PPPPLVTTDD LSSDDDRRFL LYVGTTGYVV SDPPVASSVV RRGARAPHPP P--------- PPPPLVTTDD LSSDDDRRFL LYVGTTGYVV SDPPKASSVV HHGARTPHPP P--------- PPPPLVTTDD LSSDDDKKYL LYVGLLGYVV SDPPVTKKVV EEGVKTPHPP P--------- PPPPLVTTDD LSSDDDRRFL LYVGTTGYVV SDPPKTKKVV RRGVRATHPP PGG------- PPPPLVTTDN LSSDDDRRFL LYVGTTGYVV SDPPRTKKVV QQGVRAGHPP P--------- PPPPLVTTDN LSSDDDRRFL LYVGTTGYVV SDPPRTSSVV RRGVKAAHPP P--------- PGGGLITTDL LSSDDDRRFL LYFLHHGYII SNPPRTQQII FFGIRGGSVV VQQEE-DDDD PGGGLITTDL LSSDDDRRFL LYFLHHGYII SNPPRTQQII FFGIKGGSVV VQQEE-DDDD PGGGLITTDL LSSDDDRRFL LYFLHHGYII SDPPRTQQLL FFGIKGGPVV VQQEE-DDDD PGGGLITTDL LSSDDDHHFL LYFLHHGYVV SDPPRTQQLL FFGIKDGPVV VQQDD-DDDD PGGGLITTDL LSSDDDRRFL LYFLHHGYII SDPPRTQQLL FFGIKGGPVV VQQEE-DDDD PGGGLITTDL LSSDDDRRFL LYFLHHGYII SDPPR----- ---------- ---------- PGGGLITT-- ---------- ---------- ---------- ---------- ---------- PGGGLITTDL LSSDDDRRFL LYFLHHGYII SDPPRTQQLL FFGIKGGPVV VQQEE-DDDD PGGGLITTDL LSSDDDRRFL LYFLHHGYII SDPPRVQQII FFGIKGGPVV VQQEE-DDDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SNNNEFPPPW IFFSSDLLLI IIF------- ---------- ---------- ---------- PGGGLITTDL ISSDDDRRFL LYFLHHGYII TDPPKVQQII FFGIRGGPVV VTTEE-DDDD PGGGLITTDL ISSDDDRRFL LYFLHHGYII TDTPKVQQII FFGIRGGPVV VTTEE-DDDD PGGGLITTDL ISSDDDRRFL LYFLHHGYII EDLPVTQQLL WWGIKGSPVV VAAGG-EEEE PGGGLITTDL ISSDDDRRFL LYFLHHGYII EDVPKTQQVV WWGIKGSPVV VVVKK-DDDD PGGGLITTDL ISSDDDRRFL LYFLHHGYII EDPPVTQQII WWGLKGSPVV VKKGG-EEEE PGGGLITTDL ISSDDDRRFI IYFLHHGYII EDPPVTQQII WWGLKGSPVV VKKGG-EEEE PGGGLITTDV ISSDDDRRYL LYLLHHGYII EDPPVAQQVV WWGLKGSEVV VVVTT-EEEE PAAALITTDL ISSDDDRRFL LYVLHHGYII SDPVKNQQVV YYGVTESNVV VKKEE-GGGG PAAALITTDL ISSDDDRRFL LYVLHHGYII SDPPKNQQVV FFGISETTVV VKKEE-EEEE ---------- ---------- ---------- ---------- ---------- ---------- GGGGMMTTDL ISSDDDRRYL LYFRHHGYII SDRPRTQQVV FFGIRDAPRR RRRNN-DDDD GGGGMISSDI ISSDDDRRFL LYVRHHGYII TDPPKTQQLL FFGISDLPNN NVVKKEDDDD ---------- ---------- ---------- ---------- ---------- ---------- IPPPLPVVDS IAADDDQQTL LWIMDDGFII SDPPFIEEKK VVDV------ ---------- VPPPLPVVDS ISSDDDSSRL LWVMDDGFII SDPPRVEEKK TTGV------ ---------- --------AG GAAPQMLLLL LLIISRRDDD DRYVTLYYST TDDNNQQQFP PEEGLKKWMM --------SG GAAPQMIIII IIVVSRRDDD DRYITLYYSS SNNNNQQQFP P--GLRRWMM --------NG GGGPQMVVVV VVIISRRDDD DRYWTLYYST TDDDDQQQFP PDDGVPPAQQ --------NA AGGPQMVVVV VVIISRRDDD DRYWTLYYST TDDDDQQQFP PDDGVPPVEE --------NY YGGPQMVVVV VVIISRRDDD DKYWTLYYST TDDEEQQQFP PGGDRGGAMM --------KG GGGPQMVVVV VVIISRRDDD DRYFTLYYGA ADDPPQQQFP PEEGIDDWMM --------TG GGGPQMVVVV VVIISRRDDD DRYFTLYYRA ADDEEQQQFP PDDGIKKWMM --------AG GGGPQMVVVV VVVVSRRDDD DRYFSLYYAS SDDEEQQQFP PVVGIRRWII QELTTCQLKG GGGPQMIIII IILLSLLDDD DKYATLYYSD DDDKKQQQF- -PPDLIIEGG QELTTCQLKG GGGPQMIIII IILLSLLDDD DKYVTLYYSA ADDKKQQQF- -PPNLIIEGG QELKKSQLKG GGGPQMIIII IILLSLLDDD DKYVTLYYSA ADDKKQQQF- -PPDLIIEGG QELDDSQLKG GGGPQMIIII IILLSLLDDD DKYVTLYYSA ADDKKQQQF- -PPDLIIEGG QELKKSQLKG GGGPQMIIII IILLSLLDDD DKYITLYYSA ADDKKQQQF- -PPDLIIEGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EELKKSQLKG GGGPQMIIII IILLSLLDDD DKYITLYYSA ADDKKQQQF- -PPDLIIEGG QELKKSQLKG GGGPQMIIII IILLSLLDDD DKYVTLYYSD DDDKKQQQF- -PPDLIIEGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KDLEECQVKG GGGPQMIIII IILLSLLDDD DKYVTLYYSK KDDKKQQQF- -PPDMIIEGG KELEECQVKG GGGPQMIIII IILLSLLDDD DKYVTLYYSI IDDKKQQQF- -PPDLLLEGG DGKTTWQPQG GGGPQMIIII IILLTLLDDD DKYVTLFFSA ADDKKQQQF- -PPGLVVKGG DGETTWQPQG GGGPQMIIII IILLSLLDDD DKYVTLFFSA ADDKKQQQF- -PPKLVVQGG DGNSSFQPKG GGGPQMIIII IILLSLLDDD DKYATLFFSA ADDRRQQQF- -PPELMMKGG DGNTTFQPKG GGGPQMIIII IILLSLLDDD DKYATLFFSA AVVVVSSSF- -PPEIMMKGG DDKEEEQPKG GGGPQMIIII IILLSLLDDD DKYVTLFFSR RDDEEQQQFG GQQDLVVKGG EK----PLKG GGGPQMLLLL LLLLSLLDDD DKYVTLYYKK KDDDDQQQF- -PPEHVVSGG DHD---ELKG GGGPQMLLLL LLLLSLLDDD DKYVSLYYKK KDDDDQQQF- -PPENVVSGG ---------G GGGPAKIIII IILLSVVDDD DKYVTFYYST TDDKKQQQF- -PPNVVVEGG PELKKEAVKG GGGPQMLLLL LLLLSLLDDD DRYVSLFFSP PDDKKQQQF- -PPEMVVAGG KELKKERRKG GGGPQMLLLL LLLLSLLDDD DKYVSLYYSP PDDKKQQQF- -PPKMVVQGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MVVVV VVQQSWWDDD DKYFSLLLAN NDD------- -------KGG ---------- -----MVVVV VVSSSWWDDD DQYYTLLLAN NDD------- -------KGG KLLA------ PPLLEEIDKK EFFVDDGGG- ---------R SVRDASSSSS SYYYYYY--- KVVV------ PPLLEELEKK EFFVDDGGG- ---------R AVRDASSTTT TFFYYYY--- LAAA------ PPLLTTLADD DWWVEEPPPG GG-------R AIRDCSSTTT TFFYYYYSSS MAAV------ GGLLEELDKK DFFVSSPPPG GG-------R AIRDCSSTTT TFFYYYYSSS MAAV------ EELLTTLDKK DWWVDDPPPG GG-------R SIRDCSSTTT TFFYYYYSSS KLLA------ PPIIEEFDPP KFFLEEPPPG GG-------R PVRDCSSSSS SYYYYYY--- KVVV------ PPMMQQFDPP NFFVDDGGG- ---------R VIRDASSSSS SYYFFFF--- KAAA------ PPLLSSLDPP GFFTEEGGGG GG-------R PIRDSSSSSS SYYYYYYSSS VMMQDDVDTT VVLLKKLNPP NLLVDDGGGE EEPLLGGGGL ALRDCSSSSS SWW------- VMMQDDVDTT AALLKKLNPP NLLVDDGGGE EEPLLGGGGL ALRDCSSSSS SWW------- VMMQDDVDTT VVLLKKLNPP NLLVDDGGGE EEPLLGGGGL ALRDCSSSSS SWW------- VMMQDDVDTT VVLLTTLNPP NLLVDDGGGE EEPLLGGGGL ALRDCSSSSS SWW------- VMMQDDVDTT VVLLKKLNPP NLLVDDGGGE EEPLLGGGGL ALRDCSSSSS SWW------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VMMQDDVDTT VVLLKKLNPP NLLVDDGGGE EEPLLGGGGL ALRDCSSSSS SWW------- VMMQDDVDTT VVLLKKLNPP NLLVDDGGGE EEPLLGGGGL AIRDCTTSSS SWW------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VMMQDDVDTT EELLKKLNPP NLLVDDGGGE EEPGGGGGGL ALRDCSSSSS SWW------- VMMQDDVDTT KKLLKKLNPP NLLVDDGGGE EEPDDGGGGL AIRDCTTSSS SWW------- HIIQDDVDTT EELLKKINPP NFFVDDGGGE EEPDDGGGGL AMRDCTTSSS SWW------- HIIQDDVDTT EELLKKINPP NFFVDDGGGE EEPDDGGGGL AMRDCTTSSS SWW------- HIIQDDVDTT EELLSSINPP NFFVDDGGGE EEPEEGGGGL AMRDCTTSSS SWW------- HIIQDDGDTT EELLTTINPP DFFVDDGGGE EEPDDGGGGL AMRDCTTSSS SWW------- HMMQDDVDTT EELLSSINPP NFFVDDGGGE EEPEEGGGGL AMRDCTTSSS SWW------- TMMQNNIDPP EEMMEEINRR DLLIDDGGGI IIEGGGGGGL AMRDCTTSSS SWW------- TMMQDDVDPP IIMMVVINKK NLLIDDGGGV VVPGGGGGGL AMRDCTTSSS SWW------- VMMQDDVDTT EELLTTVNKK NLLVDDGGGE EEPNNGGGGL AIRDSTTSSS SLL------- TIIQDDIDVV EEMMKKLNEE NLLVDDGGGE EEPYYGGGGL PMR------- ---------- HIILDDVDTT VVIISSLNEE DLLVDDAAAE EEPYYGGGGL PMRDCTTSSS SWWAAAADDD ---------- ---------- ---------- ---------- ---------- ---------- DDDQLLKAYY NNKKEELVEE DAAVDDYYYL LLGLLGGGGR AMRALYYSSS S--------- DDDQLLKLYY YYKKEELKEE QAAIDDYYYE EEKLLGGGGR PMRALYYAAA AAADDDDNNN ------- ------- VVK---- VV----- VV----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AA----- ------- ------- RRLQRVV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NNKKAAKKKK QQEEEEAATC RTTAAAVTLL LTTLLAAAAA DGAASPTLSG SSSPRIKAAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYQAWFSSAI QVLASSSSSS ESGKKTTRRR RRSPGGLVEE ISSSAAVAAK VVVVVVPSQA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMARATLLPL NNRTTPPPPP NPAAASSPPP PPPPRRVPLL TRRLVVRPPY TTTTIINVPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----AVVPPK RRRDDTFYYP PMAMEDVCCC ---------- ---------- ---------- -----AAKKK PPPDDTFYYP PDAMEDVAAA ---------- ---------- ---------- -----MMSSR PPPDDTFHHA ALAMEETLLL ---------- ---------- ---------- -----MMTTR PPPDDTFHHA ALAMENTLLL ---------- ---------- ---------- -----MMTTR PPPDDTFYYP PLAMEKTMMM ---------- ---------- ---------- -----AATTK PPPDDSFYYP PLAAETVMMM ---------- ---------- ---------- -----VVTTR PPPDDTFYYP PMAVEKVRRR ---------- ---------- ---------- -----AASSR PPPDDTFYYP PMAMERVLLL ---------- ---------- ---------- ---AKTTKK- CCCGGGYPPT TAMKEELCCC ---------- ---------- ---------- ---------- ---------- ---MEELCCC AAAAVQWWLP PPKKKHGAAA LLLAARGGLL LPGSQGGKK- CCCGGGYPPS SAMKEELCCC ---------- ---------- ---------- ---------- ---------- --MKEELCCC ---------- ---------- ---------- ---AKGGNN- CCCGGGYSST TAMKEELCCC ---------A AAAAAEGAFF LLLSAQPPMR RPIAKGGNN- CCCGGGYSST TAMKEELCCC ---------- ---------- ---------- ---AKGGNN- CCCGGGYSST TAMK------ ---------- ---------- ---------- ---AKGGNN- CCCGGGYSST TAMKEELCCC -------GLG GGEEEPGHTT QQQWLSGGQL LWQAKGGDD- CCCGGGYPPT TAMKEELCCC ------LNSQ QQLLLGFDQQ NNNEHTYYCT TLVPKGGNN- CCCGGGYSST TAMKEELCCC ---------- ---------- ---------- ---AKGGNN- CCCGGGYSST TAMKEELCCC PPRRLPCHAR RRLLLVLQHH MMMGAAVVET TAAGTCCHHA KKKGGGYAAT TAMEEKVCCC ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MKGGSS- CCCGGGYKKS SAMKEELCCC ---------- ---------- MMMTLDHHGV VVNSVGGCCK SSSGGGYAAS SSMSESVAAA ---------- ---------- MMMTLQHHAV VVSNQGGCCK SSSGGGYAAS SAMSETVAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMLLV GGGGGGYAAT TAMSEKVAAA ---------- ---------- ---------M MAAGACCGGA TTTGGGYAAT TAMEEKVCCC ---------- ---------- ---------- -MSGKHHGG- ---GGGYAAS SAIKEEVAAA ---------- ---------- ---------- -MPPKHHGG- ---GGGYAAS SAIKEEVAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----SSSKKK CCCGGGYAAT TAVREKVCCC ---------- ---------- ---------- ---------- ---------- --MREKTTTT ---------- ---------- ---------- ---------- ---MMGLIIT TILIRFSWWW --------MK KKEEEFG--- ------AALA AAGAGPPFFA FFFAAETCCQ QMPKEEVTTT --------MK KKIIIVSGPP MMMFLRAALV VSGAAPPAAV RRRAAETCCA AMKKEDVTTT TGIIRRRRAA DDIAAVVVDD DPKSEEYYKK KVVVEEPPPN NDEHHHFFAS SCC-PNGGG- TGVVAAAAPP DDLAAVVVDD DPKSPPYYKK KLLLDDPPPG GDEHHHFFAS SCC-PNAAA- FS--RRRRPP DDLAAVVIDD DPGSSSYYKK TVVVTTPPPG GDEHHHFFAS SSS-PLTTTG FS--KKKKPP DDLAAVVIDD DPGSPPYYQQ TVVVTTPPPG GDEHHHFFAS SSS-PLAAAG AS--KKKKPP DDLAAVVVDD DPTSEEFFQQ QLLLIIPPPG GDEHHHFFAS SSS-PLTTTG RK--QQQQPP DDIAAVVVDD DPASPPYYSS QVVVAAPPPG GDEHHHFFAS SCC-PNAAAP ANGGKKKKPP DDMCCVVVDD DSQSSSFFQQ VTTTDDPPPG GGEHHHFFAS SCC-PNAAAP RE--RRRRPP DDLGGVVLDD DPDSGGYYQQ RVVVEEPPPA ADEHHHFFAS ACC-PYAAAP TGTTAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPK KDEHHHSSTS S-----FFFG TGIIAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPK KDEHHHSSTS S-----FFFG TGIIAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPR RDEHHHSSAS S-----FFFG TGIIAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPK KDEHHHSSTS S-----YYYG TGTTAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPK KDEHHHSSTS S-----FFFG TGTTAAAAPP DDLAATTVDD DPKSPPYYQQ ---------- ---------- ---------- --TTAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPK KDEHHHSSTS S-----FFFG TGTTAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPK KDEHHHSSTS S-----FFFG TGTTAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPK KDEHHHSSTS S-----FFFG TGTTAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPK KDEHHHSSTS S-----FFFG TGTTAAAAPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPK KDEHHHSSTS S-----FFFG TGIIKKKKLL DDLAATTVDD DPSSPPYYQQ RLLLPPIIIG GDKHHHSSSS S-----HHHG ---------- ---------- ---------- ------PPPN NDEHHHSSTS S-----YYYG TGIIKKKKPP DDLAATTVDD DPKSPPYYQQ RLLLPPPPPN NDEHHHSSTS S-----YYYG TGIIKKKKPP DDLAATTVDD DPSSPPYYKK RLLLPPPPPG GDEHHHTTSS S-----HHHG TGIIKKKKPP DDLAATTVDD DPNSPPYYKK RLLLPPPPPG GDEHHHTTSS S-----HHHG ---------- ---------- ---------- ------PPPG GDEHHHSSSS S-----HHHG TGIIKKKKPP DDLAATTVDD DPSSPPYYSS RLLLPPPPPG GDEHHHSSSS S-----HHHG TGIIKKKKPP DDLGGTTVDD DPNSPPYYQQ RLLLPPTTTG GDEHHHSSAS S-----HHHG NAAAGGGGPP DDIFFTTVDD DPESDDFFQQ RVVVDDPPPG GDEHHHTTAS S-----HHHD HARRGGGGPP DDIFFTTVNN NPESEEFFQQ RVVVDDPPPG GDEHHHTTAS S-----HHHD ---------- ---------- ---------- ---------- ---------- ---------- LDEEHHHHGG DDLAATTVDD DPASPPYYQQ RTTTYYNNNH HNEHHHSSTS SFFVP-GGGG LDEEHHHHGG DDLSSTTVDD DPESPPYYQQ RTTTFFNNNG GDEHHHSSAS SYYVDESSSS IRQQDDDDII TTRKKNNPRR RGQVFFGGSS DGGGPPKKKE EDKLLLSSPI L--------G GMGGEEEEQQ DDLVVTTIDD DPGSAARRQQ SVVVSSGGGR RNEHHHGGA- ---------- GVGGEEEEQQ DDLVVTTVDD DPKSPPYYKK TLLLSSGGGR RNEHHHSSD- ---------- -KNRRRFLLL VVPGLLRRRS SRRIIIIDKP NPPREPIIIV VVIPEEVVVV VSGGGYYYHT -KFRRRYLLL VVPALLRRRS SRRIIIIDKP DKKRRPVVAI IIVPEVAARR RTGGGYYYHT GHFRRRFLLL IIPGLLRRRS SRRIIIVDKP HPPTQAIIHI IIIPDEIIKK KTGGGYYYHT GHFRRRYLLL IIPGLLRRRS SRRIIIIDKP DPPTKAIIHI IIIPEEVVKK KTGGGYYYHT GHFRRRYLLL IIPGIIRRRS SRRIIIIDK- EPPLKAIIHI IIIPEEVVKK KTGGGYYYHT PHHRRRYLLL VVPGLLRRRS SRRIIIIDKP DPPLKPLLAV VVIPETLLRR RTGGGYYYHT PHHRRRYLLL VVPDIIRRRS SHHIIIIDKP DPPTQPVVVV VVIPNELLRR RTGGGYYYHT PHHRRRYLLL VVPGIIRRRS SRRIIIIDKP DPPREPIIVV VVIPEELLRR RTGGGYYYHT GDTNNNKLLL LLPGLLMMMS SRRIIIVDGS EPPRAPLLHV VVIASEIIKK KCNNNVVVHT GDTDDDKLLL LLPSIIIIIS SRRIIIVDGS EPPRAPLLHV VVIPNEIIKK KCNNNLLLHT GDTTTTKLLL LLPCLLMMMS SRRIIIVDGS DPPRAPLLHV VVIAEDIIKK KCGGGLLLHT GDTTTTKLLL LLPALLIIIS SRRIIIVDGT EPPRAPLLHV VVIPKDIIKK KCNNNLLLHT GDTTTTKLLL LLPSLLIIIS SRRIIIVDGS EPPRAPLLHV VVIPEDIIKK KCEEELLLHT ---------- ---------- ---------- ---------- ---PKDIIKK KCEEELLLHT GDTTTTKLLL LLPSLLIIIS SRRIIIVDGS EPPRAPLLHV VVIPKDIIKK KCEEELLLHT GDTTTTKLLL LLPSLLIIIS SRRIIIVDGS EPPRAPLLHV VVIPKDIIKK KCEEELLLHT GDTNNNKLLL LLPSFFIIIS SRRIIIVDGT EPPRAPLLHV VVIAKDIIKK KCGGGLLLHT GDTTTTKLLL LLPSLL---- ---------- ---------- ---------- ---------- GDTTTTKLLL LLPSLLIIIS SRRIIIVDGS EPPRAPLLHV VVIPKDIIKK KCEEELLLHT GDSRRRFLLL LLPSLLLLLS SRRVVVVDAT DPPRTPLLHV VVVSEDIINN NIGGGLLLHT GDSNNNKLLL LLPCLLIIIS SRRIIIVDGT DPPRAPIIHT TTVPYEVVKK KCGGGLLLHT GDSNNNKLLL LLPCLLIIIS SRRIIIVDGS DPPRAPIIHT TTVPYEVVKK KCGGGLLLHT GDSRRRFLLL AAPSLLVVVS SRRIIIVDKT NPPRSPLLHV VVVPADIIKK KTGGGLLLHT GDSRRRFLLL VVPGIIVVVS SRRVVVVDKT NPPRAPLLHV VVVPEDIIKK KTGGGLLLHT GDSRRRYLLL LLPSLLIIIS SRRIIIADKE NPPRAPLLYY YYVPKEIIKK KTGGGLLLHT GDSRRRYLLL LLPSLLIIIS SRRIIIADKE NPPRAPLLYY YYVPKEIIKK KTGGGLLLHT GDSRRRFLLL LLPSLLLLLS SRRVVVVDLK DPPRAPLLHV VVVAEDIIKK KTGGGLLLHT DKTSSSHLLL VVPCLLNNNS SRRIIIINEN E--RKILLET TTIPSKLLLL LN---LLLHT DKTSSSHLLL VVPCLLNNNS SRRIIIVNEN E--REILLQT TTIPSKLLLL LN---LLLHT -------MMM PPRKLLSSSS SVVEEEKFGG ---------- ---------- ---------- GKVDDDRLLL LLPCLLNNNS SRRIIIVDGT DPPRAPLLAV VVIG-DVVGG GADDDCCCHT SKVDDDRLLL LLPSLLNNNS SFFIIIIDVT DPPRKPIIVT TTIG-DVVSS SHNNNVVVHT GKVPPPQMMM QQLSLLDDDG GRRLLLVTLY SAAWDKFFY- -----DLLFF FLVVVLLLHT ---RRRFFFF TTGGLLDDDT TRRIIIIDHS DPPSNPLLHT TTIT-FVVSS SGGGGVVVHT ---RRRYLLL AAGGLLDDDT TKKIIIVDHS DPPARPLLST TTID-FVVSS SGGGGVVVHT TPDAIYISAA LGNNEE---- EEGG-GIILL LMMHYEELGG GGGKIIIIQ- ------LLAY TPDAIYISAA LGGGPP---- DDGGRGIIFF FLLHDEEIGG GGGRVVVVQ- ------FFAY TPEGIYVSTT LGGGAAGGKK DDGGTGIIFF FIICEDDLGG GGGRIIIIQ- ------KKHY TPDGIYVSTT LGGGGGGGKK DDGGTGVVFF FIICEEELGG GGGRIIIIQ- ------LLHY TPEGIYVSTT LGGGGGGGEE DDGGTGIIFF FIICEEELGG GGGRMMMMQ- ------KKHY TPGGIYVTAA LGNNAA---- EEGG-GIIAA AMMAQEELGG GGGRVVVVQ- ------FFAY TPDGIYISAA LGSSPP---- EEGG-GIIFF FIIHDEELGG GGGRIIIIQ- ------LLHY TPDGVYVSAA LGSSPP---- EEGG-GVVFF FVVHEDDLGG GGGRVVVVQ- ------LLAY TASGEVMVNN TLGGDD---- LLQQGSFFVV VLLGEEEKGG GGGTKKKKS- ------MMGY TASGEVMISS SLGGDD---- PPQQGGFFVV VLLGEEEKGG GGGTKKKKA- ------MMGY TASGEVMISS TLGGDD---- SSKKGGFFVV VLLGEEEKGG GGGTQQQQA- ------MMGY TPSGEVMVSS TLGGDD---- PPEEGGFFVV VLLGKEEKGG GGGTQQQQA- ------LLGY TASGEVMISS SLGGDD---- VVKKGGFFVV VLLGEEEKGG GGGTRRRRA- ------SSGY TASGEVMISS SLGGDD---- VVKKGGFFVV VLLGEEEKGG GGGTRRRRA- ------LLGY TASGEVMISS SLGGDD---- VVKKGGFFVV VLLGEEEKGG GGGTRRRRA- ------LLGY TASGEVMISS SLGGDD---- VVKKGGFFVV VLLGEEEKGG GGGTRRRRA- ------LLGY TPTGEVMISS TLGGDD---- PPKKGGFFVV VLLGEEEKGG GGGTRRRRA- ------MMGY ---------- ---------- ---------- ---------- ---------- ---------- TASGEVMISS SLGGDD---- VVKKGGSSLL LVVP-EESGG GGG------- ---------- TASGDIMISS CLGGDD---- KKEEGNGGFF FLLDSNNKGG GGGRNNNNI- ------KKER TGCGEIMISS SIGGDD---- PPYYGGFFVV VLLGEEEKGG GGGNAAAAA- ------FFGY TGCGEIMISS SLGGDD---- PPCCGGFFVV VLLGEEEKGG GGGNVVVVA- ------FFGY TASGELMISS CLGGDD---- KKDDGNGGFF FLLDSNNKGG GGGRKKKKP- ------FFGY TASGEIMISS CIGGDD---- KKDDGNGGFF FLLDSNNKGG GGGRKKKKP- ------FFGY TASGEILVSS CLGGDD---- EEEEGNGGFF FLLDSNNKNN NNNRKKKKP- ------FFGY TT-GEILVSS CLGGDD---- EEEEGNGGLL LLLDSNNKNN NNNRKKKKP- ------YYGY TASGEIMISS CLGGDD---- KKEEGNGGFF FLLDSNNKGG GGGRKKKKP- ------FFGY TADGNIMISS TLGGEE---- AANNGNFFLL LLLGKEEKGG GGGTAAAAV- ------FFNY TADGNIMISS TLGGEE---- AADDGNFFLL LLLGKEEKGG GGGTAAAAV- ------FFNY ---------- ---------- ---------- ---------- ---------- ---------- TPNGNIMISS IMGGDD---- AAEEG-DDFF FVVDKEEVGG GGGTRRRRA- ------CCGY TANGNIMISS VMGGDD---- AAEEG-DDFF FIIDSNNIGG GGGTKKKKA- ------CCGY TPNTALKQDD GVNNEE---- SSLLSNGGII IQQKHGGSAA AAAKAAAAE- ------LLQL TPGSMMITGG LSNNDD---- DDDDHALLVV VEEDDYYATT TTTYPPPPMG VVAAGDYYGY TPGRMLITGG LSNNNN---- KKDDHALLVV VEENAYYATT TTTHPPPPLG IIKKGDYYDY DWWWW--PNN NVSSSWWAVP ---TTTEDGG G--LKLLEHD DRGNNRIHWW WLLKKRKKII DWWWW--PSS SITSSWWTVP ---CCCEEGG G--FSLLECE EAGNNKLHWW WLLKKRRRLL DWWWW--PRR RVSSSWWALP ---QQQENGG G--IVPPEDA AKGHHRLHWW WLLAARRRVV DWWWW--PRR RVTSSWWALP ---QQQENGG G--IVPPEDS SKGHHRLHWW WLLAARRRVV DWWWW--PRR RVSSSWWGLP ---QQQENGG G--IVPPEDS SKGHHKIHWW WLLDDRKKVV DWWWW--GYY YVTSSWWGTP ---MMMEDGG G--LVPPDIG GRGRRRLHWW WLLRRRRRLL DWWWW--GYY YLTSSWWGTP ---MMMESGG G--VLGGDEA AKGHHRLHWW WLLRRRRRLL DWWWW--GYY YVTSSWWGTP ---MMMEGGG G--LDPPQIN NGGRRRLHWW WLLRRRRRLL DWWWY--RHH HVSTTWWAAP ---VVVKDGG GFFNPAAHV- -LGSSRIFWW WWWRRHEEII DWWWY--RHH HVSTTWWAAP ---VVVKDGG GFFNPAAHV- -LGSSHIHWW WWWRRHEEII DWWWY--RHH HISTTWWAAP ---VVVRDGG GFFNPAADV- -LGSSHLHWW WWWRRHEEII DWWWY--RHH HISTTWWAAP ---VVVRDGG GFFNPAADV- -LGSSHLYWW WWWRRREEVV DWWWY--RHH HISTTWWAAP ---VVVRDGG GFFNPAADV- -LGSSHLYWW WWWHHHEEVV DWWWY--RHH HISTTWWAAP ---VVVRDGG GFFNPAADV- -LGSSHLYWW WWWRRHEEVV DWWWY--RHH HISTTWWAAP ---VVVRDGG GFFNPAADV- -LGSSHLYWW WWWRRHEEVV DWWWY--RHH HISTTWWAAP ---VVVRDGG GFFNPAADV- -LGSSHLYWW WWWRRHEEVV DWWWY--RHH HISTTWWAAP ---VVVQNGG GFFNPAADV- -LGKKHLHWW WWWRRHEEVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---AASSAHS ---LLLLTGG GSSRDYYPA- -RAGGIT--- ---------- TLLLYYYAWW WWSWWQQCCS ---FFFTTGG GAAELMMCL- -GHVVISCDD DYYMMRVVDD DWWWY--RHH HISTTWWGAP ---AAAALGG GFFKMEEEV- -MGHHSLNWW WWWEEHRRII DWWWY--RHH HISTTWWGAP ---AAAALGG GFFKMEEDV- -HGHHSLNWW WWWEEHRRVV DWWWY--RHH HISTTWWGAP ---AAATKGG GFFDLQQHV- -LGRRHLTII ILLRRGEERR DWWWY--RHH HISTTWWGAP ---AAALQGG GFFNLQQHV- -LGRRHLHYY YWWGGGEEKK DWWWY--RHH HISTTWWGAP ---AAASKGG GFFDLQQHV- -LGSSHLHYY YWWGGGEEKK HWWWY--RHH HISTTWWGAP ---AAASKGG GFFNLQQHV- -LGSSHLHYY YWWGGGEEKK DWWWY--RHH HISSSWWGAP ---AAARTGG GFFDLQQHV- -LGRRHLHYY YWWGGGEEKK DWWWY--RRR RISTTWWGSP ---HHHKKGG GFFNPAAHV- -LGNNSVHFF FWWSSKKKLL DWWWY--RRR RISTTWWGSP ---HHHKKGG GFFNPAAHV- -LGNNSVHFF FWWTTKKKLL ---------- --SIIRRGGP ---TTTCRDD DEEELKKCQ- -LIKKCKRYY Y--------- DWWWY--HFF FVASSWWGAP ---LLLRRGG GYYHPTTDCR RQGCCRLNYY YWWEEREEFF DWWWY--YFF FVSSSWWGAP ---KKKRRGG GWWKNVVDLM MQGCCRLNYY YWWTTQTTYY SHHHN---RR RESDDPPDEP ---MMMFESS SSSESFFLKG GLPQQHVAVV V--------- DRRRA--RKK KLTSSFFTGW NNYMMMDFGG GQQMLQQDAM MRGNNTIVWW WLLTTRQQKK DRRRA--RKK KVTSSFFTGW NNYMMMDFGG GKKMLAADPM MHGNNTVVWW WLLTTKQQKK IHHTTTLLEE RML----ELL HDPTKKGFNM VSLLDSSILF FYY-GKWWWN AEVIEEAAEP LYYDDDLLEE RML----EVV HDPTKKGFNV VNTTDSSILF FYY-GKWWWQ AEVIDDAAQP VQQDDDLLQQ QML----EVV HDPVRRGFGV VDTTNESITW WRR-GKFFFH VKTATTAAEP VQQDDDLLNN QML----EVV HDPVRRGFGV VDTTNESITW WRR-GKFFFH AETATTPPEP VQQDDDLLNN QML----EII HDPSKKGFGV VDTTNQAITW WQQKGTFFFE AKTITTPPVP LQQDDDFFEE QLF----ELL HDPTKKGFNC VSLLDSSITY YRR-DKWWWA VRVIEEAAEA LQQDDDLLEE QML----ELL HDPTKKGFNC VSLLDSSILY YRR-GSWWWH LKVIDDAAEP LQQDDDVVEE QML----ELL HDPARRGFGV VSLLDSSVLH HRR-GSWWWG IRVIEEAAEP IQQQQQMM-- GLP---LEII HDPSAAGFGC ASSSIRYKEG G--------- ---TWWEEKV IQQQQQMM-- GLP---LEII HDPDAAGFGC ASSSIRYKEG G--------- ---TWWEEKV IQQTTTLL-- GLP---LEII HNPDAAGFGC ASSSIRYKQG G--------- ---TWWEEKV VQQPPPLL-- GLP---LEII HNPDAAGFGC ASSSIRFKEG G--------- ---TWWQQKV VQQSSSLL-- GLP---LEII HNPDAAGFGC ASSSIRYKEG G--------- ---TWWEEKV VQQSSSLL-- GLP---LEII HNPDAAGFGC ASSSIRYKEG G--------- ---TWWEEKV VQQSSSLL-- GLP---LEII HNPDAAGFGC ASSSIRYKEG G--------- ---TWWEEKV VQQSSSLL-- GLP---LEII HNPDAAGFGC ASSSIRYKEG G--------- ---TWWEEKV VQQLLLMM-- GHP---LEII HDPAAAGFGC ASSSIRYKEG G--------- ---TWWEEKV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DEEPPPLL-- QAANPPLCLL HWKNIIDYVV ESFFGGSDDY Y--------- ---AVVKKRK IQQDDDLL-- GLP---LEII HDPDAAGLGC ASSSVRYKKG G--------- ---KWWEEKV VQQDDDLL-- GLP---LEII HNPDAAGLGC ASSSIRYKKG G--------- ---KWWEEKV RQQDDDLL-- GLP---LEII HDPAKKGFGS ASSSMRFKQG G--------- ---SWWEELA KQQDDDLL-- GLP---LEII HDPAKKGFGS ATSSMRFKQG G--------- ---SWWEEIV KQQDDDLL-- GLP---LEII HDPSKKGYGS ASSSMRFKSD D--------- ---TWWEEIV KQQDDDLL-- GLP---LEII HDPSKKGFGS ASSSMRFKSE E--------- ---TWWEEVV KQQDDDLL-- GLP---LEVV HDPSKKGYGC ATSSMRFKAG G--------- ---SWWEEVA LQQDDDLLPP GAP---LEVV HEPTSSAFGC AGSSIRHPEN NSS------- ---THHTTLV LQQDDDLLPP GAP---LEVV HEPTSSAFGC AGSSIRHPEN NPP------- ---VQQSSLV ---------- ---------- ---------- ---------- ---------- ---------- FQQDDDLL-- GLP---LEII HNPREEGYGC AXXXXXX--- ---------- ---------- YQQDDDLL-- GIP---LEII HNPKKKGFGC ANAAVHKKSS SDD------- --FEAAVVID ---------- ---------- ---------- ---------- ---------- ---------- KKKNNNVVAA ------LEII WGSNAAAFTT ATSSLLYEDG G--------- ---------- KKKDDDVVAA ------LEII WGEAHHCFST ATSSLLYEGG G--------- ---------- LLLGG-NLEI ILLPFAAAPV VIDISSSSLL DKKLSLGGGE EVQQQYDDDS SNPPLVKLLG FFFGG-PLPV VLLDFMMMPV VIDISSSSLL DRRLSLGGGE ELQQQYDDDT TNPPLVKIIG AAAAADELPL LLLGFAAAPV VIDLSSSSLL DRRLSCGGGE EMQQQYDDDS SDPPLVRIIG AAAKKEKLPL LLLGFAAAPV VIDLSSSSMM DRRLSCGGGE EMQQQYDDDS SDPPLVHIIG AAAAADDLDL LLLGFAAAPV VIDLSSSSLL DKKLACGGGE EMQQQYDDDS SDPPLVEIIG AAAPPDQLPV VLLGFAAAPV VIDLSSSSMM DRRLSCGGGD DLQQQYDDDS SDPPLVRIIG AAAEEDQLPI ILLPFAAAPV VINLSSSSVV DRRLSCGGGE ELQQQYDDDS SDPPLVQIIG AAAPPDQLPL LLLDFAAAPV VINLSSSSLL DRRLSCGGGE ELQQQYDDDS SDPPHVRLLG IIIVVPSKVK KGGMLEEEGI IILLSSSSLL DRRLSNLLGD DIQQQYDDDS SNPPLIFLLG IIIVVPSKVK KGGMLEEEGI IILLSSSSLL DRRLSNLLGD DIQQQYDDDS SNPPLIFLLG IIIVVPPKVK KGGMLEEEGI IILLSSSSLL DRRLSNLLGD DLQQQYDDDS SDPPLLFLLG IIIVVPPKVK KGGMLEEEGI IILLSSSSLL DHHLSNLLGD DIQQQYDDDS SDPPLLFLLG IIIVVPPKVK KGGLLEEEGI IILLSSSSLL DRRLSNLLGD DLQQQYDDDS SDPPLLFLLG IIIVVPPKVK KGGLLEEEGI IILLSSSSLL DRRLSNLLGD DLQQQYDDDS SDPPL----- IIIVVPPKVK KGGLLEEEGI I--------- ---------- ---------- ---------- IIIVVPPKVK KGGLLEEEGI IILLSSSSLL DRRLSNLLGD DLQQQYDDDS SDPPLLFLLG IIIVVPPKVK KGGMLEEEGI IILLSSSSLL DRRLNNLLGD DMQQQYDDDS SDPPLIFLLG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLLLLYYAVA AKKGVSSSNF FAWIFFFFFF SLLILS---- ---------- ---------- IIIVVPSKVE EGGALEEEGI IILISSSSLL DRRLSNLLGD DIQQQYDDDT TDPPLIFLLG IIIVVPSKVE EGGPMEEEGI IILISSSSLL DRRLSNLLGD DIQQQYDDDT TDPPLIFLLG IIIVVKPLVQ QNNILEEEGI IFLISSSSLL DRRLVNLLGD DIQQQYNNNE EDPPLLWVVG IIIVVEPLVQ QNNFLEEEGI IFLISSSSLL DRRLVNLLGD DIQQQYNNNE EDPPLVWAAG IIIVVKPLVE ENNILEEEGI IFLISSSSLL DRRLVNLLGD DIQQQYNNNE EDPPLIWVVG IIIVVKPLVE ENNILEEEGI IFLISSSSLL DRRIVNLLGD DIQQQYNNNE EDPPLIWVVG IIIIIKPLVR RNNILEEEGI IFVISSSSLL DRRLVNLLGD DIQQQYNNNE EDPPLVWAAG AAAIIPSKVS SGGALEEEAI IILISSSSMM DRRLSCLLGD DIQQQYDDDS SDVVLVYIIG AAAIIPSKVE ENNALDDDAI IILISSSSMM DRRLSCLLGD DIQQQYDDDS SDPPLVFIIG ---------- ---------- ---------- ---------- ---------- ---------- --------GE ENNEIMMMGM MILISSSSLL DRRLSNRRGD DVQQQYDDDS SDPPLVFLLG IIIGGKLVTG GSSVADDDGI IIIISSSSLL DRRLNCRRGD DVQQQYDDDT TDPPLLFLLG ---------- ---------- ---------- ---------- ---------- ---------- ---WWQAKVA ADDGNAAAPP PISIAAAAAA DQQLNSMMGK KTLLLFDDDS SDPPQKVIIR ---WWQAKVA ADDGEAAAPP PISISSSSNN DSSLNTMMGK KTLLLFDDDS SDPPQKTIIA GGGGIHHADH H--------- --------GL TAAQLLLEIR GRRVVTNSSS TWDNFYYKKG GGGGLHHEPH H--------- --------GA TAAQIIISVR GRRVVTNSSS SWNNFYYRRG GGGGIRRAPH H--------- --------GF AGGQVVVEIR GRRVVTNSSS TWDDFYYPPA GGGGIRRTPH H--------- --------GF AGGQVVVEIR GRRVVTNSSS TWDDFYYPPG GGGGIKKTPH H--------- --------GF GGGQVVVEIR GRRVVTNSSS TWDEFYYGGA GGGGISSATH HG-------- -------ANL NGGQVVVEIR GRRVVTNGGG AVDPFYYDDG GGGGIRRAGH H--------- -------ASL NGGQVVVEIR GRRVVTNRRR AWDEFYYKKG GGGGIRRAAH H--------- --------SL NGGQVVVEVR GRRVVSNAAA SWDEFYYRRG GGGGSVVGGS SQVVVVLLE- CCEEPPVVGI PGGQIIIQLL GRRLLTTSSS DWDKFYYIIR GGGGSVVGGS SQVVVVLLE- CCEEPPVVGV PGGQIIIQLL GRRLLTTSSS AWDKFYYIIR GGGGSVVGGP PQVVVVLLE- SSEEPPVVGV PGGQIIIQLL GRRLLTTSSS AWDKFYYIIR GGGGSVVDGP PQVVVVLLD- SSEEPPVVGV AGGQIIIQLL GRRLLTTSSS AWDKFYYIIR GGGGSVVGGP PQVVVVLLE- SSEEPPVVGV AGGQIIIQLL GRRLLTTSSS AWDKFYYIIR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGGSVVGGP PQVVVVLLE- SSEEPPVVGV AGGQIIIQLL GRRLLTTSSS AWDKFYYIIR GGGGSVVGGP PQVVVVLLE- SSEEPPVVGV PGGQIIIQLL GRRIITTSSS DWDKFYYIIR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGGSLLGGP PTVVVVLLE- CCDDPPIVGV PGGQIIIQLL GRRLLTNSSS KWDKFYYIIK GGGGSQQGGP PTVVVVLLE- CCDDPPTVGI PGGQIIIQLL GRRIITSSSS IWDKFYYLLK GGGGLQQGSP PAAAAAIIG- WWDDVVEIGL RGGQIIIQLL GRRLLTNSSS AWDKFYYVVE GGGGLQQGSP PVAAAAVVK- WWDDVVEIGL RGGQIIIQLL GRRLLTNSSS AWDKFYYVVE GGGGLQQGSP PKAAAAVVG- FFDDVVQIGL RGGQIIIQLL GRRLLTNSSS AWDRFYYMMD GGGGLQQGSP PKAAAAVVG- FFEEVVQIGL RGGQIIIQLL GRRLLTNSSS AWVVFYYMME GGGGLQQGSE EVYYYYVVT- EESSVVQVGL RGGQIIIQLL GRRIITNSSS RWDEFYYVVK GGGGSHHESN NKVVVVLLE- --EEAAYVGI EGGQLLLQLL GRRLLTTKKK KWDDFYYVVK GGGGSHHETT TKVVVVLLE- --PPAAYVGI EGGQLLLQLL GRRLLSTKKK KWDDFYYVVR ---------- ---------- ---------- -GGAIIIQLV GRRLLTNSSS TWDKFYYVVK GGGGAQQDAP PRVVVVLLN- EEEEPPFLGL LGGQLLLQLL GRRLLSSSSS PWDKFYYVVA GGGGACCDLP PVIIIIVVKE EEPPAAYVGL EGGQLLLQLL GRRLLSSSSS PWDKFYYVVS ---------- ---------- ---------- ---------- ---------- ---------- RRRRQNN--- ---------- ---------- ----VVVSQW GRRVVSSAAA NWD------K AAAAQNN--- ---------- ---------- ----VVVSSW GRRLLTSAAA NWD------K MLLLLLLNAN ---PSSSLEI IDEVVVDGE- ----ARRSQQ QRSDDDSSSS SDSYC----- MVVVVVVNVN ---PEEELEL LEEVVVDGR- ----ARRAQQ QRWDDDSSTT TDSFC----- QAAAAAAHAG ---PDDDLTL LADVVVEPD- ----YRRAQQ QREDDDSSTT TDSFCSVV-- EAAAAAANVG ---GNNNLEL LDDVVVSPD- ----YRRAQQ QREDDDSSTT TDSFCSVV-- MAAAAAANVG ---ENNNLTL LDDVVVDPA- ----YRRSQQ QREDDDSSTT TDSFCSVV-- MLLLLLLDAG ---PNNNIEF FDKLLLEPK- ----HRRPQQ QRQDDDSSSS SDSYC----- MVVVVVVDVN ---PDDDMQF FDNVVVDGE- ----QRRVQQ QRQDDDSSSS SDSYC----- IAAAAAAEAD ---PGGGLSL LDGTTTEGD- ----LRRPQQ QREDDDSSSS SDSYCS---- GMMMMMMLQV DDDVNNNLKL LNNVVVDGKP GGPPALLAEE ERPDDDSSSS SDIWI----- GMMMMMMLQI DDDANNNLKL LNNVVVDGKP GGPPALLAEE ERPDDDSSSS SDIWI----- GMMMMMMLQI DDDVKKKLKL LNNVVVDGKP GGPPALLAEE ERPDDDSSSS SDIWL----- GMMMMMMLQI DDDVKKKLTL LNNVVVDGKP GGPPALLAEE ERPDDDSSSS SDIWL----- GMMMMMMLQV DDDVKKKLKL LNNVVVDGKP GGPPALLAEE ERPDDDSSSS SDIWI----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GMMMMMMLQV DDDVKKKLKL LNNVVVDGKP GGPPALLAEE ERPDDDSSSS SDIWI----- GMMMMMMLQI DDDVKKKLKL LNNVVVDGKP GGPPALLAEE ERPDDDTTSS SDIWL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GMMMMMMLQI DDDEKKKLKL LNNVVVDGKP GGPPVLLAEE ERPDDDSSSS SDIWV----- GMMMMMMLQI DDDKKKKLKL LNNVVVDGKP GGPPVLLAEE ERPDDDTTSS SDIWI----- GIIIIIILQI DDDEKKKLKI INNVVVDGAP GGPPALLAEE ERPDDDTTSS SDIWI----- GIIIIIILQI DDDENNNLKI INNVVVDGAP GGPPSLLAEE ERPDDDTTSS SDIWI----- GIIIIIIIQI DDDEKKKLSI INNVVVDGDP GGPPALLAEE ERPDDDTTSS SDIWI----- GIIIIIIIQI DDDEKKKLTI INDVVVDGDP GGPPSLLAEE ERPDDDTTSS SDIWI----- GMMMMMMLQI DDDEKKKLSI INNVVVDGAP GGPPSLLAEE ERPDDDTTSS SDIWI----- GMMMMMMVQV NDDESSSMEI INDIIIDGKE GGPPYLLAEE ERPDDDTTSS SDIWI----- GMMMMMMLQI DDDITTTMVI INNIIIDGKP GGPPYLLAEE ERPDDDTTSS SDIWI----- GMMMMMMLQI DDDEKKKLTV VNNVVVDGKP GGPPCLLADD DRPDDDTTSS SDILA----- GIIIIIIVQL DDDENNNMKL LNNVVVDGGP GGPPGLLPEE ER-------- ---------- GIIIIIIVLI DDDVNNNISL LNDVVVDANP GGPPSLLPEE ERPDDDTTSS SDIWLDAA-- ---------- ---------- ---------- ---------- ---------- ---------- GDDDDDDAQY LAANWWWKEL LVDVVVDYEG GG---RRAII IRGAAAYYSS SS-------- GDDDDDDEQF LLLYWWWKEL LKQIIIDYAK GG---RRPQQ QRGAAAYYAA AGPAGNRRQQ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AARRVEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSAAKKAA QPEEATTTTT TAPTTGTARL LADDGAAMMQ SSSRTTAAAQ QLSTTPVRRA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYQAAWWTTT SAQQASSSSE SSKKRRSSVP GVESSAAKKV VVPSAAAVWA LPPKAAAVII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AEAAAFTQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGKEHHTAPP ---------- ---------- ---------- ---------- --------LL SQGLDDQTTT ---------- ---------- ---------- ---------- ---------- ---------- MMARRAAPPP PPNNTTPPPN PPLLPPPPHP RPLRLVPYYT IINVPPPLCP ARHLQQHIEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------AA ---------- ---------- ---------- ---------- ---------- --------GG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MKRE------ ---------- ---------- ---------- ---------- ---------- MKRIGGPSHH ---------- ----MMMAAP FFKKKPPTTT PSPPKMAPEL AYVVCCCYTG GTTTTTNNRR ---------- ---------K LLKKKPPTTT PTPPRDAPEI AYVVAAAYVG GTTTTTNNAA ---------- ---------S MMRRRPPTTT ASPPELAPEF AYTTLLLSPD DFFFFF--RR ---------- ---------T MMRRRPPTTT ASPPKLAPEF AYTTLLLSPD DFFFFF--KK ---------- ---------T LLRRRPPTTT PSAAKLAPEL AFTTMMMSPD DAAAAA--KK ---------- ---------T WWKKKPPSSS PSPPRLAPEI AYVVMMMDPE ERRRRR--QQ ---------- ---------T WWRRRPPTTT PSPPRMAPEL AYVVRRRNPM MAAAAA--KK ---------- ---------S WWRRRPPTTT PSPPKMAPEL GYVVLLLDPG GRRRRR--RR ---------- ---ATTTKKK -----PPGGG TPLLEAMPEI VYLLCCCYRN NTTTTTEEAA ---------- ---------- ---------- -------PEI VYLLCCCYRN NTTTTTEEAA APAAGGGLP- --ASTTTQQK -----PPGGG SPLLEAMPEI VYLLCCCYGN NTTTTTEEAA ---------- ---------- ---------- ------MPEI IYLLCCCYRN NTTTTTEEAA ---------- ---ATTTKKN -----PPGGG TPLLEAMPEI VYLLCCCYRN NTTTTTEEAA SVAAPPPMPA AASATTTKKN -----PPGGG TPLLEAMPEI VYLLCCCYRN NTTTTTEEAA ---------- ---ATTTKKN -----PPGGG TPLLEAM--- ---------- ------EEAA ---------- ---ATTTKKN -----PPGGG TPLLEAMPEI VYLLCCCYRN NTTTTTEEAA WFLLGGGQWE EEDATTTKKD -----PPGGG TPQQEAMPEI VYLLCCCYRN NTTTTTEEAA ELHHYYYCLF FFTPTTTKKN -----PPGGG TPLLEAMPEI VYLLCCCYRN NTTTTTEEAA ---------- ---ATTTKKN -----PPGGG TPLLEAMPEI VYLLCCCYRN NTTTTTEEAA GAAAVVVEAA AAAGKKKTTH TTAAAPPGGG TPLLEAMPEL VYVVCCCYNG GTTTTTNNKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MAAAKKS -----PPGGG SPLLDAMPEI VYLLCCCYRS STTTTTNNKK TVLLHHHGVE EEKS---VVC CCKKKPPGGG SPIIESMPEL IYVVAAAYAG GTTTTTEEKK TVLLHHHAVE EEKNNNNQQC CCKKKPPGGG SPLLEAMPEL IYVVAAAYAG GTTTTTEEKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------L QQVVVPPGGG TPLLAAMPEL IYVVAAAYTG GTTTTTDDKK --------AA AAAGAAAAAG GGAAAPPGGG TPLLEAMPEL LYVVCCCYNG GTTTTTNNKK --------MP PPNGLLLKKG -----PPGGG SPAADAIPEV LFVVAAA--- -NNNNNDDGG --------M- ---PLLLKKG -----PPGGG SPAADAIPEV LFVVAAA--- -HHHHHDDGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMMSSK CCKKKPPGGG TPLLDAVPEL LYVVCCCQPN NLLLLLEEHH ---------- ---------- ---------- ------MPEL LYTTTTTQPN NLLLLLPPHH ---------- ---------- -----PPGGG T---DILDRL YFSSWWWHGD DIIIIIYYDD ----AAALA- --AAMMMGGF RRAAADDEEE QSPPYMPGEF VYVVTTTGVE EGGGGGDDEE FALLAAALSL LLAALLLAAA GGVVVDDEEE ASPPYMKGEY VYVVTTTGAE EGGGGGDDEE AADDAVNNKK SETTTSIIVH HELPNNDELH HHFFFFFFAA LL-NNGG--- NIEEIVVGLS PPDDAVDDKK SPTTTGVVIY YDLPGGDELH HHFFFFFFAA YY-NNAA--- FLEEIVVALS PPDDAVKKGG SSTTTGIIVH HTMPGGDEFH HHFFFFFFAS LL-LLTTGGG FLEEIIIGLS PPDDAVKKGG SPTTTGIIVH HTMPGGDEFH HHFFFFFFAA LL-LLAAGGG FIEEIIIGLS PPDDAVDDTT SEKKKGIIVH HIMPGGDEFH HHFFFFFFAA LL-LLTTGGG FLEEIIIGIS PPDDAVDDAA SPRRRAIIVG GAMPGGDELH HHFFFFFFAC LL-NNAAPPP HMEEVVVGLS PPDDCVDDQQ SSTTTGVVVG GDMPGGGELH HHFFFFFFAM LL-NNAAPPP HVEEVVVDIS PPDDGVDDDD SGTTTAIIVG GEMPAADELH HHFFFFFFAA LL-YYAAPPP HVEEIVVGIS PPDDATDDKK SPQQQSVVIH HPMPKKDELH HHSSSSSSTC -----FFGGG TKSSILLGLS PPDDATDDKK SPHHHSVVIH HPMPKKDELH HHSSSSSSTC -----FFGGG TKSSILLSIS PPDDATDDKK SPQQQCVVIH HPMPRRDELH HHSSSSSSAC -----FFGGG TKSSMLLCLS PPDDATDDKK SPQQQCVVIH HPMPKKDELH HHSSSSSSTC -----YYGGG TKAAVLLALS PPDDATDDKK SPQQQCVVIH HPMPKKDELH HHSSSSSSTC -----FFGGG TKSSVLLSLS PPDDATDDKK SPQQQCVVIE E--------- ---------- ---------- ---------- PPDDATDDKK SPQQQCVVIH HPMPKKDELH HHSSSSSSTC -----FFGGG TKSSVLLSLS PPDDATDDKK SPQQQCVVIH HPMPKKDELH HHSSSSSSTC -----FFGGG TKSSVLLSLS PPDDATDDKK SPQQQSVVIH HPMPKKDELH HHSSSSSSTC -----FFGGG TKSSVLLSFS PPDDATDDKK SPQQQCVVIH HPMPKKDELH HHSSSSSSTC -----FFGGG TKSSVLLSL- PPDDATDDKK SPQQQCVVIH HPMPKKDELH HHSSSSSSTC -----FFGGG TKSSVLLSLS LLDDATDDSS SPTTTSVVIH HPVIGGDKLH HHSSSSSSSC -----HHGGG SAKKILLSLS ---------- ---------- --MPNNDELH HHSSSSSSTC -----YYGGG SKVVILLCLS PPDDATDDKK SPSSSSVVIH HPMPNNDELH HHSSSSSSTC -----YYGGG SKVVILLCLS PPDDATDDSS SPTTTSVVIH HPVPGGDELH HHTTTTTTSC -----HHGGG SAEEIAASLS PPDDATDDNN SPTTTSVVIH HPVPGGDELH HHTTTTTTSC -----HHGGG SAQQIVVGIS ---------- ---------- --MPGGDELH HHSSSSSSSC -----HHGGG SADDVLLSLS PPDDATDDSS SPSSSSVVIH HPMPGGDELH HHSSSSSSSC -----HHGGG SVDDVLLSLS PPDDGTDDNN SPTTTSVVIH HPVTGGDELH HHSSSSSSAC -----HHGGG SASSILLSLS PPDDFTNNEE SDTTTCVVIS SDVPGGDEVH HHTTTTTTAC -----HHDDD TEKKIVVCLS PPDDFTNNEE SETTTCIIIS SDVPGGDEVH HHTTTTTTAC -----HHDDD TEKKIVVCLS ---------- ---------- ---------- ---------- ---------- ----VPPKLS GGDDATDDAA SPTTTCVVIH HYTNHHNELH HHSSSSSSTC HHV--GGGGG VPTTVLLCLS GGDDSTDDEE SPTTTCIIVH HFTNGGDELH HHSSSSSSAC YYVEESSSSS VPKKVLLSLS IITTKNVVQQ VFLLLGVVLK KPVKEEDKEL LDSSSSSSPK -------GGG VQGGLQQSLG QQDDVTRRGG SATTTGVVIN NSVGRRNEAH HHGGGGGGA- ---------- --DDWTTGLT QQDDVTNNKK SPQQQGVVVN NSVGRRNEAH HHSSSSSSD- ---------- --DDWAAGLT SRIIIIIIID KKPPPPRRRP PKVPEEEEVK KKKVSGGYLL HTTHAAAAII IYIISSSAN- SRIIIIIVVD KKPPKKRRRP PAIPEEEEAV VGGRTGGYYY HTTHAAAAII IYIISSSAG- SRIIVVVIID KKPPPPTTTA ARIPDDDDIL LAAKTGGYPP HTTHGGGGII IYVVSSSTGK SRIIIIIIID KKPPPPTTTA AKIPEEEEVF FKKKTGGYPP HTTHGGGGII IYVVSSSTGK SRIIIIIVVD KK--PPLLLA AKIPEEEEVF FAAKTGGYPP HTTHGGGGII IYVVSSSTGE SRIIIIILLD KKPPPPLLLP PFVPEEEELA AEERTGGYPP HTTHGGGGII IYVVTTTAN- SHIIIIILLD KKPPPPTTTP PKVPNNNNLA AEERTGGYPP HTTHGGGGII IYIISSSAS- SRIIIIIVVD KKPPPPRRRP PRVPEEEELH HRRRTGGYPP HTTHGGGGVV VYVVSSSAS- SRIIVVVVVD GGSSPPRRRP PKVASSSSIQ QAAKCNNVTT HTTHGGGGEE EVMMVVVNG- SRIIVVVVVD GGSSPPRRRP PKVPNNNNIH HAAKCNNLLL HTTHGGGGEE EVMMIIISG- SRIIVVVVVD GGSSPPRRRP PKVAEEEEIH HAAKCGGLVV HTTHGGGGEE EVMMIIISG- SRIIVVVVVD GGTTPPRRRP PKVPKKKKIH HTTKCNNLFF HTTHGGGGEE EVMMVVVSG- SRIIVVVVVD GGSSPPRRRP PKVPEEEEIH HAAKCEELLL HTTHGGGGEE EVMMIIISG- ---------- ---------- ---PKKKKIH HAAKCEELLL HTTHGGGGEE EVMMIIISG- SRIIVVVVVD GGSSPPRRRP PKVPKKKKIH HAAKCEELLL HTTHGGGGEE EVMMIIISG- SRIIVVVVVD GGSSPPRRRP PKVPKKKKIH HAAKCEELLL HTTHGGGGEE EVMMIIISG- SRIIVVVVVD GGTTPPRRRP PKVAKKKKIH HEEKCGGLPP HTTHGGGGEE EVMMIIISG- ---------- ---------- ---------- ---------- ---------- ---------- SRIIVVVVVD GGSSPPRRRP PKVPKKKKIH HAAKCEELLL HTTHGGGGEE EVMMIIISG- GRVVVVVVVD AATTPPRRRP PSVSEEEEIA AEENIGGLPP HTTHGGGGDD DIMMIIISG- SRIIVVVVVD GGTTPPRRRP PRTPYYYYVF FWWKCGGLLL HTTHGGGGEE EIMMIIISG- SRIIVVVVVD GGSSPPRRRP PRTPYYYYVF FWWKCGGLPP HTTHGGGGEE EIMMIIISG- GRIIVVVIID KKTTPPRRRP PSVPAAAAII IQQKTGGLPP HTTHGGGGEE ELMMIIISG- GRVVVVVIID KKTTPPRRRP PSVPEEEEIS STTKTGGLPP HTTHGGGGEE EIMMIIISG- GRIIAAAIID KKEEPPRRRP PSYPKKKKIA AEEKTGGLPP HTTHGGGGEE EILLVVVSG- GRIIAAAIID KKEEPPRRRP PSYPKKKKIA ADDKTGGLPP HTTHGGGGEE EILLVVVSG- GRVVVVVVVD LLKKPPRRRP PAVAEEEEIA AEEKTGGLPP HTTHGGGGEE EIMMIIISG- DRIIIIIIIN EENN--RRRI IYTPSSSSLH HSSLN--LPP HTTHGGGGNN NIMMIIISG- DRIIVVVIIN EENN--RRRI IYTPSSSSLH HAALN--LPP HTTHGGGGNN NIMMIIISG- GVEEKKKVVF GGGG------ ---------- ---------- ---------- ---------- DRIIVVVIID GGTTPPRRRP PKVG----VL LKKGADDCPP HTTHGGGGNN NIMMIIISG- DFIIIIILLD VVTTPPRRRP PETG----VL LKKSHNNVPP HTTHGGGGNN NIMMIIISG- KRLLVVVTTT LLYYAAWWWK KQ------LI IKKFLVVLSS HTTDTTTTAA ALKKQQQDN- NRIIIIIFFD HHSSPPSSSP PKTT----VK KDDSGGGVPP HTTFSSSSMM MMIITTTGN- SKIIVVVFFD HHSSPPAAAP PVTD----VE EKKSGGGVPP HTTYRRRRMM MLIITTTGN- GGEPPGIIHY SEGGGEIDR- ---------- ----LYDFFW WNLL-NVVVV SSSWVTIEED GGEPPGIIHD TEGGGEVYR- ---------- ----FYDFFW WNLL-SVVVI TTSWVCFEEE GGDAAPIICE TDGGGEIDR- ---------- ----KYDFFW WNLL-RYYYV SSSWLQFEEN GGNPPPVVCE TEGGGEIDR- ---------- ----LYDFFW WNLL-RYYYV TTSWLQFEEN GGDPPPIICE TEGGGEMDR- ---------- ----KYDFFW WNLL-RYYYV SSSWLQFEEN GGKPPGIIAQ SEGGGEVER- ---------- ----FYDGGW WHLL-YTTTV TTSWTMVEED GGEPPGIIHD NEGGGEIDR- ---------- ----LYDFFW WHLL-YTTTL TTSWTMVEES GGDPPGVVHE SDGGGEVER- ---------- ----LYDFFW WHLL-YTTTV TTSWTMIEEG QQNKKGFFGE TEGGGEKPG- ---------- ----MYDFFW YQPP-HVVVV SSTWAVFKKD QQNKKGFFGE TEGGGEKPG- ---------- ----MYDFFW YQPP-HIIIV SSTWAVFKKD KKNKKGFFGE TEGGGEQPG- ---------- ----MYDFFW YQPP-HVVVI SSTWAVFRRD EENKKGFFGK TEGGGEQPG- ---------- ----LYDFFW YQPP-HVVVI SSTWAVLRRD KKNKKGFFGE TEGGGERPG- ---------- ----SYDFFW YQPP-HVVVI SSTWAVLRRD KKNKKGFFGE TEGGGERPG- ---------- ----LYDFFW YQPP-HVVVI SSTWAVLRRD KKNKKGFFGE TEGGGERPG- ---------- ----LYDFFW YQPP-HVVVI SSTWAVLRRD KKNKKGFFGE TEGGGERPG- ---------- ----LYDFFW YQPP-HVVVI SSTWAVLRRD KKNKKGFFGE TEGGGERPG- ---------- ----MYDFFW YQPP-HVVVI SSTWAVVQQN ---------- ---------- ---------- ---------- ---------- ---------- KKNKKDSSP- REGGG----- ---------- ---------- ---------- --ASHLRLLT EENAAGGGDS ENGGGSNRL- ---------- ----KRTHHL YENNYWLLLW SSWQCFYTTT YYNKKGFFGE TEGGGEAEG- ---------- ----FYDFFW YQPP-HVVVI SSTWAAFAAL CCNKKGFFGE TEGGGEVEG- ---------- ----FYDFFW YQPP-HVVVI SSTWAAFAAL DDNEEGGGDS DNGGGEKPG- ---------- ----FYDFFW YQPP-HTTTI SSTWAAFTTK DDNEEGGGDS ENGGGEKPG- ---------- ----FYDFFW YQPP-HTTTI SSTWAAFLLQ EENKKGGGDS DNNNNEKPG- ---------- ----FYDFFW YQPP-HTTTI SSTWAAFSSK EENKKGGGDS DNNNNEKPD- ---------- ----YYHFFW YQPP-HTTTI SSTWAAFSSK EENAAGGGDS ENGGGEKPG- ---------- ----FYDYYW YQPP-HTTTI SSSWAAFRRT NNTSSGFFGK TEGGGPADE- ---------- ----FYDFFW YQPP-RVVVI SSTWSHIKKK DDSSSGFFGK TEGGGPADG- ---------- ----FYDFFW YQPP-RIIII SSTWSHIKKK ---------- ---------- ---------- ---------- ---------- SSIRGTVCCR EENKKGDDDK NEGGGSRGD- ---------- ----CYDYYW YQPP-FVVVV AASWALFRRR EEYKKGDDDS DNGGGTKGD- ---------- ----CYDFFW YQPP-FVVVV SSSWAKWRRR LLVVVLGGKH EGAAAEASQ- ---------- ----LLSNNH NNGG-RKKKE SSDPEMAFFE DDGRRTLLDD GYTTTMPTAG AAAAADDDAA VADGYYDIIR ALII-KVVVL TTSFGMMDDF DDGRRTLLNA GYTTTIPTDG AKKKK---KK YADGYYDVVR ALPP-KLLLV TTSFGMMDDF GG-LLLKLEH --RRGIHHHW LLRKKRRIHL LLTLGERL-- -----ELLPD PKKKKLLLMG GG-FFFSLEC GGAAGLHHHW LLAKRHHLYI IIDLGERL-- -----EVVPD PKKKKLLLMG GG-IIIVPED NNKKGLHHHW LLRARNNVQI IIDLGQQL-- -----EVVPD PRRRREEEYG GG-IIIVPED NNKKGLHHHW LLRARNNVQI IIDLGNQL-- -----EVVPD PRRRREEEYG GG-IIIVPED NNKKGIHHHW LLRDKNNVQI IIDLGNQL-- -----EIIPD PKKKKDDDYG GG-LLLVPDI AARRGLHHHW LLTRRHHLQI IIDFGEQF-- -----ELLPD PKKKKAAAYG GG-VVVLGDE GGKKGLHHHW LLYRRHHLQL LLDLGEQL-- -----ELLPD PKKKKAAAYG GG-LLLDPQI KKGGGLHHHW LLRRRHHLQL LLDVGEQL-- -----ELLPD PRRRRTTTYG GGFNNNPAHV GGLLGIFFFW WWQREIIIQL LLQMT-GP-- --LLLEIIFD PAAAATTTQG GGFNNNPAHV GGLLGIHHHW WWQREIIIQL LLQMK-GP-- --LLLEIIFD PAAAATTTQG GGFNNNPADV GGLLGLHHHW WWQREIIIQL LLTLQ-GP-- --LLLEIIFN PAAAAAAAQG GGFNNNPADV GGLLGLYYYW WWQREIIVQL LLPLQ-GP-- --LLLEIIFN PAAAAAAAQG GGFNNNPADV GGLLGLYYYW WWQHEIIVQL LLSLK-GP-- --LLLEIIFN PAAAAAAAQG GGFNNNPADV GGLLGLYYYW WWQREIIVQL LLSLK-GP-- --LLLEIIFN PAAAAAAAQG GGFNNNPADV GGLLGLYYYW WWQREIIVQL LLSLK-GP-- --LLLEIIFN PAAAAAAAQG GGFNNNPADV GGLLGLYYYW WWQREIIVQL LLSLK-GP-- --LLLEIIFN PAAAAAAAQG GGFNNNPADV GGLLGLHHHW WWQREIIVQL LLLMP-GP-- --LLLEIIFD PAAAASSSQG ---------- ---------- ---------- ---------- ---------- ---------- GGSRRRDYPA SSRRAT---- ---------- ---------- ---------- ---------- GGAEEELMCL SSGGHSCCCD YYIMVIIDEL LLPLQ-QANN PILLLCLLSW KIIIINNNQD GGFKKKMEEV GGMMGLNNNW WWTERRRIQI IIDLG-GP-- --LLLEIIFD PAAAAAAAQG GGFKKKMEDV GGHHGLNNNW WWTERLLVQI IIDLG-GP-- --LLLEIIFN PAAAADDDQG GGFDDDLQHV GGLLGLTTTI LLARELLRQL LLDLG-GP-- --LLLEIIFD PKKKKDDDTG GGFNNNLQHV GGLLGLHHHY WWPGEIIKQL LLDLG-GP-- --LLLEIIFD PKKKKDDDTG GGFDDDLQHV GGLLGLHHHY WWPGEMMKQI IIDLG-GP-- --LLLEIIFD PKKKKDDDTG GGFNNNLQHV GGLLGLHHHY WWPGEIIKQI IIDLG-GP-- --LLLEIIFD PKKKKDDDTG GGFDDDLQHV GGLLGLHHHY WWPGELLKQL LLDLG-GP-- --LLLEVVFD PKKKKDDDTG GGFNNNPAHV GGLLGVHHHF WWDSKYYLQI IIDLPPGP-- --LLLEVVFE PSSSSEEEHA GGFNNNPAHV GGLLGVHHHF WWDTKHHLQI IIDLPPGP-- --LLLEVVFE PSSSSEEEHA DDEEEELKCQ PPLLIKRRRY ---------- ---------- ---------- ---------- GGYHHHPTDC TTQQGLNNNY WWQEELLFQI IIDLG-GP-- --LLLEIIFN PEEEENNNQG GGWKKKNVDL SSQQGLNNNY WWSTTLLYQI IIDLG-GP-- --LLLEIIFN PKKKKAAAEG SSSEEESFLK PPLLPVAAAV ---------- ---------- ---------- ---------- GGQMMMLQDA KKRRGIVVVW LLHTQPPKKF FFNVPA---- --LLLEIIFG SAAAANNNYA GGKMMMLADP KKHHGVVVVW LLHTQPPKKF FFDVPA---- --LLLEIICG EHHHHNNNYC FFNVVSSSLK DDIWFY-EDG GGKKNNNAAK VIIEIPPEPE EGNLPPPIIL KKKFKKAAVV FFNVLNNNTK DDIWFY-EDG GGKKQQQAAR VIIDIEEQPE EGPLPPPVVL KKKFKKMMVV FFGVVDDDTT NNIWWR-EGG GGKKHHHVVK TAATIPPEPT TAELPPPLLL QQQFGGAAVV FFGVVDDDTT NNIWWR-EGG GGKKHHHAAK TAATIPPEPP PKKLPPPLLL QQQFGGAAVV FFGVVDDDTT NNIWWQKDDG GGTTEEEAAK TIITIDDVPD DADLPPPLLL KKKFGGAACC FFNVISSSLK DDIWYR-DKD DDKKAAAVVK VIIEIPPEAD DPQLPPPVVL KKKFKKAAVV FFNVVSSSLK DDIWYR-DNG GGSSHHHLLK VIIDIPPEPS SEQLPPPIIL KKKFKKAAVV FFGVVSSSLE DDVWHR-QNG GGSSGGGIIK VIIEIPPEPE EPQLPPPLLL KKKFGGAAVV FFGALSSSSN IIKEG----- ---------- -TTWSVVKVQ QVSKKKKKKG WWWLPPEEMM FFGALSSSSN IIKGG----- ---------- -TTWSVVKVQ QVSKKKKKKG WWWLPPEEMM FFGALSSSST IIKGG----- ---------- -TTWSVVKVQ QVPKKKKKKG WWWLPPEEMM FFGALSSSST IIKDG----- ---------- -TTWSAAKVQ QVPKKKKKKG WWWLPPEEMM FFGALSSSST IIKGG----- ---------- -TTWSVVKVQ QVPKKKKKKG WWWLPPEEMM FFGALSSSST IIKGG----- ---------- -TTWSVVKVQ QVPKKKKKKG WWWLPPEEMM FFGALSSSST IIKGG----- ---------- -TTWSVVKVQ QVPKKKKKKG WWWLPPEEMM FFGALSSSST IIKGG----- ---------- -TTWSVVKVQ QVPKKKKKKG WWWLPPEEMM FFGALSSSST IIKGG----- ---------- -TTWSVVKVE EVPKKKKKKG WWWLPPEEMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYVEVSSSFS GGDAY----- ---------- -AAVVLLRKD DLYAVVVAAK FFFVVVSSLL LLGALSSSST VVKDG----- ---------- -KKWAAAKVK KVSKKKKEEG WWWLPPEEMM LLGALSSSSS IIKDG----- ---------- -KKWAAAKVQ QVSKKKKEEG WWWMPPEEMM FFGALSSSSN MMKDG----- ---------- -SSWSHHLAP PVPLKKKQQN WWWLPPEEMM FFGALTTTSN MMKDG----- ---------- -SSWNHHIVS SVPLKKKQQN WWWLPPEEMM YYGALSSSSN MMKDD----- ---------- -TTWSYYIVS SVPLKKKEEN WWWLPPEEMM FFGALSSSSN MMKDE----- ---------- -TTWSHHVVS SVPLKKKEEN WWWLPPEEMM YYGALTTTSN MMKDG----- ---------- -SSWSHHVAS SIPLKKKRRN WWWLPPEEMM FFGALGGGSG IIPENS---- ---------T -TTHAAALVF FISKKKKSSG WWWLPPEEMM FFGALGGGSA IIPKNP---- ---------K -VVQTAALVT TISKKKKEEN WWWLPPDDMM ---------- ---------- ---------- ---------- ---------- ---------- YYGAFXXXXX XX-------- ---------- ---------- ----QQQEEN GGGIEEMMMM FFGALNNNAK VVKDSD---- ---------E FEEAKKKIDP PGLVDDDGGS GGGAEEDDMM ---------- ---------- ---------- ---------- ---------- ---------- FFTALTTTSQ LLEAG----- ---------- ---------E EWAKAAAAAD IIINPPAADD FFSALTTTSQ LLEEG----- ---------- ---------E EWAKAAAAAD IIIEPPAAKK PPPPLVTDDD ISSLDDDFFL LLLSLLLGIG EVVVRYYIII SNFKPLLTGK VVLLGGFFFH PPPPLVTDDD ISSLDDDFFL LLVSLLLGLG ELLLRYYIII TNHQPLLAGR VVIIGGYYYH PPPPLVTDDD LSSLDDDFFL LLVSCCCGTG EMMMRYYVVV SDHNPLLAGS VVIIGGAAAR PPPPLVTDDD LSSMDDDFFL LLVSCCCGTG EMMMRYYVVV SDRKPLLAGS VVIIGGAAAR PPPPLVTDDD LSSLDDDYYL LLVACCCGLG EMMMHYYVVV SDMNPLLTGK VVIIGGVVVK PPPPLVTDDD LSSMDDDFFL LLVSCCCGTG DLLLLYYVVV SDFEPLLTGK VVIIGGVVVS PPPPLVTDDN LSSVDDDFFL LLVSCCCGTG ELLLHYYVVV SDFNPLLTGK VVIIGGVVVR PPPPLVTDDN LSSLDDDFFL LLVSCCCGTG ELLLRYYVVV SDFNPHHTGS VVLLGGVVVR PPPGLITDDL LSSLDDDFFL LLFSNNNLHG DIIIRYYIII SNQKPLLTGQ IILLGGIIIV PPPGLITDDL LSSLDDDFFL LLFSNNNLHG DIIIRYYIII SNKKPLLTGQ IILLGGIIIV PPPGLITDDL LSSLDDDFFL LLFSNNNLHG DLLLRYYIII SDQRPLLTGQ LLLLGGIIIV PPPGLITDDL LSSLDDDFFL LLFSNNNLHG DIIIRYYVVV SDQRPLLTGQ LLLLGGIIIV PPPGLITDDL LSSLDDDFFL LLFSNNNLHG DLLLRYYIII SDQRPLLTGQ LLLLGGIIIV PPPGLITDDL LSSLDDDFFL LLFSNNNLHG DLLLRYYIII SDQRPLL--- ---------- PPPGLIT--- ---------- ---------- ---------- ---------- ---------- PPPGLITDDL LSSLDDDFFL LLFSNNNLHG DLLLRYYIII SDQRPLLTGQ LLLLGGIIIV PPPGLITDDL LSSLDDDFFL LLFNNNNLHG DMMMRYYIII SDKRPLLVGQ IILLGGIIIV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSSNEFPPPW IFFFSSDLLI IIFLSSS--- ---------- ---------- ---------- PPPGLITDDL ISSLDDDFFL LLFSNNNLHG DIIIRYYIII TDRNPLLVGQ IILLGGIIIL PPPGLITDDL ISSLDDDFFL LLFSNNNLHG DIIIRYYIII TDRNPLLVGQ IILLGGIIIQ PPPGLITDDL ISSLDDDFFL LLFVNNNLHG DIIIRYYIII EDKNPLLTGQ LLVVGGIIIQ PPPGLITDDL ISSLDDDFFL LLFVNNNLHG DIIIRYYIII EDKNPLLTGQ VVAAGGIIIQ PPPGLITDDL ISSLDDDFFL LLFVNNNLHG DIIIRYYIII EDKNPLLTGQ IIVVGGLLLQ PPPGLITDDL ISSLDDDFFI IIFVNNNLHG DIIIRYYIII EDKNPLLTGQ IIVVGGLLLQ PPPGLITDDV ISSLDDDYYL LLLVNNNLHG DIIIRYYIII EDAKPLLAGQ VVAAGGLLLQ PPPALITDDL ISSMDDDFFL LLVSCCCLHG DIIIRYYIII SDLKVLLNSQ VVIIGGVVVH PPPALITDDL ISSMDDDFFL LLVSCCCLHG DIIIRYYIII SDKNPLLNSQ VVIIGGIIIH ---------- ---------- ---------- ---------- ---------- ---------- GGGGMMTDDL ISSLDDDYYL LLFSNNNRHG DVVVRYYIII SDANPLLTGQ VVLLGGIIIQ GGGGMISDDI ISSLDDDFFL LLVNCCCRHG DVVVRYYIII TDENPLLTGQ LLLLGGIIIC ---------- ---------- ---------- ---------- ---------- ---------- IIIPLPVDDS IAAADDDTTL LLINSSSMDG KTTTRFFIII SDHKPQQIYE KKIIDDVVVN VVVPLPVDDS ISSNDDDRRL LLVNTTTMDG KTTTRFFIII SDHHPQQVYE KKIIGGVVVN HHHRDDDP-- ---------- ---------- ------GGHT TAPMMEISRR RDRRRNNNNN HHHRPPPP-- ---------- ---------- ------GGAT TAPMMSVSRR RDRRRNNNNN RRRRPPPP-- ---------- ---------- ------GGRA AGPMMEISRR RDRRRNNNNN RRRRPPPP-- ---------- ---------- ------GGKA AGPMMEISRR RDRRRNNNNN KKKKPPPP-- ---------- ---------- ------GGKG GGPMMEISRR RDKKRNNNNN SSSRTTTPGG G--------- ---------- ----AANNGN NGPMMEISRR RDRRRNNNNN RRRRGGGP-- ---------- ---------- ----AASSAN NGPMMEISRR RDRRRNNNNN RRRKAAAP-- ---------- ---------- ------SSGN NGPMMEVSRR RDRRRNNNNN VVVRGGGVQQ QVLEEE--DE ELLTTTCCQQ EPLLVVGGKP PGPMMQLSLL LDKKRTTTTT VVVKGGGVQQ QVLEEE--DE ELLTTTCCQQ EPLLVVGGKP PGPMMQLSLL LDKKRTTTTT VVVKGGGVQQ QVLEEE--DE ELLKKKSSQQ EPLLVVGGKP PGPMMQLSLL LDKKRTTTTT VVVKGGGVQQ QVLDDD--DE ELLDDDSSQQ EPLLVVGGKA AGPMMQLSLL LDKKRTTTTT VVVKGGGVQQ QVLEEE--DE ELLKKKSSQQ EPLLVVGGKA AGPMMQLSLL LDKKRTTTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVVKGGGVQQ QVLEEE--DE ELLKKKSSQQ EPLLVVGGKA AGPMMQLSLL LDKKRTTTTT VVVKGGGVQQ QVLEEE--DE ELLKKKSSQQ EPLLVVGGKP PGPMMQLSLL LDKKRTTTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLLRGGGVTT TVLEEE--DD DLLEEECCQQ DPVVVVGGKP PGPMMQLSLL LDKKRNNNNN QQQRGGGVTT TVLEEE--DE ELLEEECCQQ DPVVVVGGKP PGPMMQLSLL LDKKRSSSSS QQQKSSSVAA AAIGGG--EG GKKTTTWWQQ DVPPIIGGQR RGPMMQLTLL LDKKRNNNNN QQQKSSSVVV VAVKKK--DG GEETTTWWQQ DVPPIIGGKR RGPMMQLSLL LDKKRNNNNN QQQKSSSVKK KAVGGG--EG GNNSSSFFQQ DVPPIIGGKR RGPMMQLSLL LDKKRNNNNN QQQKSSSVKK KAVGGG--EG GNNTTTFFQQ EVPPIIGGKR RGPMMQLSLL LDKKRNNNNN QQQKSSSVVV VYVTTT--ED DKKEEEEEQQ SVPPVVGGHR RGPMMQLSLL LDKKRNNNNN HHHTSSSVKK KVLEEE--GK K-------PP EALLVVGGRE EGPMMQLSLL LDKKRTTTTT HHHSTTTVKK KVLEEE--EH HDD-----EE PALLVVGGRE EGPMMQLSLL LDKKRTTTTT ---------- ---------- ---------- ---------- -GPKKQLSVV VDKKRNNNNN QQQRAAARRR RVLNNN--DE ELLKKKEEAA EPVVLLGGRL LGPMMQLSLL LDRRRSSSSS CCCSLLLNVV VIVKKKEEDE ELLKKKEERR PARRVVGGRE EGPMMQLSLL LDKKRSSSSS ---------- ---------- ---------- ---------- ---------- ---------- NNN------- ---------- ---------- ---------- ---MMSQSWW WDKKRSSSSS NNN------- ---------- ---------- ---------- ---MMSSSWW WDQQRSSSSS SSWDDYPLLG MKKLAAANN- PGGLLEIIIK VGGEE----- -SHHHQQVRL SGGAASSYYP SSWNNYPLLG MKKVVVVNN- PGGLLELLLK VGGRR----- -AHHHQQVRL WGGAASSYYP SSWDDYPVVA QLLAAAAGG- PGGLLTLLLD VPPDD----- -AHHHQQIRL EGGCCSSYYP SSWDDYPVVG EMMAVVVGG- GGGLLELLLK VPPDD----- -AHHHQQIRL EGGCCSSYYP SSWDDYPRRA MMMAVVVGG- EGGLLTLLLK VPPAA----- -SHHHQQIRL EGGCCSSYYP GGVDDYPIIG MKKLAAAGG- PGGIIEFFFP LPPKK----- -PHHHQQVRL QGGCCSSYYP RRWDDYPIIG MKKVVVVNN- PGGMMQFFFP VGGEE----- -VHHHQQIRL QGGAASSFFP AAWDDYPIIG IKKAAAADD- PGGLLSLLLP TGGDD----- -PHHHQQIRL EGGSSSSYYP SSWDDY-LLR GVVMQQQVVT VGGLLKLLLP VGGKKPPPLP PAHHHEELRY PGGCCSS--- SSWDDY-LLR GVVMQQQIIT AGGLLKLLLP VGGKKPPPLP PAHHHEELRY PGGCCSS--- SSWDDY-LLR GVVMQQQIIT VGGLLKLLLP VGGKKPPPLP PAHHHEELRY PGGCCSS--- SSWDDY-LLR GVVMQQQIIT VGGLLTLLLP VGGKKPPPLP PAHHHEELRY PGGCCSS--- SSWDDY-LLR GVVMQQQVVT VGGLLKLLLP VGGKKPPPLP PAHHHEELRY PGGCCSS--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSWDDY-LLR GVVMQQQVVT VGGLLKLLLP VGGKKPPPLP PAHHHEELRY PGGCCSS--- SSWDDY-LLR GVVMQQQIIT VGGLLKLLLP VGGKKPPPLP PAHHHEEIRY PGGCCTT--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSWDDY-MMK GVVMQQQIIT EGGLLKLLLP VGGKKPPPGP PAHHHEELRY PGGCCSS--- SSWDDY-LLK GVVMQQQIIT KGGLLKLLLP VGGKKPPPDP PAHHHEEIRY PGGCCTT--- SSWDDY-LLE GHHIQQQIIT EGGLLKIIIP VGGAAPPPDP PAHHHEEMRY PGGCCTT--- SSWDDY-LLE GHHIQQQIIT EGGLLKIIIP VGGAAPPPDP PAHHHEEMRY PGGCCTT--- SSWDDY-LLD GHHIQQQIIT EGGLLSIIIP VGGDDPPPEP PAHHHEEMRY PGGCCTT--- SSWVVY-IIE GHHIQQQIIT EGGLLTIIIP VGGDDPPPDP PAHHHEEMRY PGGCCTT--- SSWDDYGLLK GHHMQQQIIT EGGLLSIIIP VGGAAPPPEP PAHHHEEMRY PGGCCTT--- KKWDDY-HHK GTTMQQQVVP EGKMMEIIIR IGGKKEEEGP PAHHHEEMRY PGGCCTT--- KKWDDY-NNR GTTMQQQIIP IGHMMVIIIK IGGKKPPPGP PAHHHEEMRY PGGCCTT--- SSWDDY-VVK GVVMQQQIIT EGGLLTVVVK VGGKKPPPNP PAHHHDDIRF PCGSSTT--- SSWDDY-MMA GTTIQQQLLV EGGMMKLLLE VGGGGPPPYP PPHHHEEMR- ---------- SSWDDY-MMS GHHILLLIIT VGGIISLLLE VAANNPPPYP PPHHHEEMRY PGGCCTTAAN ---------- ---------- ---------- ---------- ---------- ---------- AAWDD----K GDDDQQQYYY NDGKKELLLE VYYEEGGGL- -AHHHIIMRF GSSLLYY--- AAWDD----K GDDDQQQFFY YDGKKELLLE IYYAAKKKL- -PHHHQQMRF GARLLYYDDG PP----- PP----- PPSV--- PPSV--- PPSV--- PP----- PP----- PPS---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- NNDA--- ------- ------- GGNRQQE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MSSKAAKKKQ RRTAVPPTGT ARLGGMSQTT PGVRKAYQEA TTFIQQVLLS PPRRSKKGGK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ------MAGS PPTLNNNRRP PPHHPLLAAA gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKKRSVGGGL VISSSSSAAA VAAKQVVVPA VQWWWLPPPP KHAAVLAAPP ARLLLLP-AA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------EEEE AEFFTLSSVV AQMMRRPASS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----GLKKKK EPTTAQWWFF LSQQLLWEDD ---------- ---------- ---------- --LLNSGGGG LGQQTNEELL HTCCTTLFTT ---------- ---------- ---------- ---------- ---------- ---------- AAAPPHRRRV PTRLLLLVVV RPPYRTTTNP LPCCHAHHHH LVHHIMGGAA AAEETTAAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MTTVV LDGGVVVEKK ---------- ---------- ---------- ---------- -----MTTVV LQAAVVVEKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMAAAA ---------- ---------- ---------- ---------- ---------- ------MPNN ---------- ---------- ---------- ---------- ---------- ------M--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MRRRR EF-------- --LLAAA-AA ---------- ---------- ---------- -----MRRRR IVPPSMFFAA LRLLVVSLAA ---AVVKKKD DDPPFPPPKK MMMMAAPPPP EEDAAAVACC LLLLGGGIIR RRADDIAADN ----AAKKKD DDPPFPPPRR DDMMAAPPPP EEDAAAVAAA LLLLGGGVVA AAPDDLAADD ----MMRRRD DDPPFAPPEE LLMMAAAAAA EEEAAATLLL LLLLSSS--R RRPDDLAADK ----MMRRRD DDPPFAPPKK LLMMAAAAAA EENAAATLLL LLLLSSS--K KKPDDLAADK ----MMRRRD DDPPFPAAKK LLMMGGVVVV EEKAAATLMM LLLLSSS--K KKPDDLAADD ----AAKKKD DDPPFPPPRR LLAAAAPPPP EETAAAVAMM FFFFKKK--Q QQPDDIAADD ----VVRRRD DDPPFPPPRR MMVVAAAAAA EEKAAAVVRR LLLLNNNGGK KKPDDMCCDD ----AARRRD DDPPFPPPKK MMMMAARRRR EERGGGVALL LLLLEEE--R RRPDDLGGDD MMAKTT---G GGPPYTLLEE AAKKGGRRRR EEEVVVLPCC IIIIGGGTTA AAPDDLAADD ---------- ---------- --MMGGRRRR EEEVVVLPCC IIIIGGGIIA AAPDDLAADD HHSQGG---G GGPPYSLLEE AAKKGGRRRR EEEVVVLPCC IIIIGGGIIA AAPDDLAADD ---------- ---------- --KKGGRRRR EEEIIILPCC IIIIGGGIIA AAPDDLAADD MMAKGG---G GGPPYTLLEE AAKKGGRRRR EEEVVVLPCC IIIIGGGTTA AAPDDLAADD TTAKGG---G GGPPYTLLEE AAKKGGRRRR EEEVVVLPCC IIIIGGGTTA AAPDDLAADD MMAKGG---G GGPPYTLLEE AAKKGG---- ---------- -------TTA AAPDDLAADD MMAKGG---G GGPPYTLLEE AAKKGGRRRR EEEVVVLPCC IIIIGGGTTA AAPDDLAADD TTAKGG---G GGPPYTQQEE AAKKGGRRRR EEEVVVLPCC IIIIGGGTTA AAPDDLAADD SSPKGG---G GGPPYTLLEE AAKKGGRRRR EEEVVVLPCC IIIIGGGTTA AAPDDLAADD MMAKGG---G GGPPYTLLEE AAKKGGRRRR EEEVVVLPCC IIIIGGGTTA AAPDDLAADD NNGTCCAAAG GGPPYTLLEE AAEEGGRRRR EEKVVVVTCC VVVVGGGIIK KKLDDLAADD ---------- ---------- ---------- ---------- ---------- ---------- --MKGG---G GGPPYSLLDD AAKKGGRRRR EEEVVVLPCC IIIIGGGIIK KKPDDLAADD KKSVGGKKKG GGPPYSIIEE SSSSGGRRRR EESIIIVTAA VVVVGGGIIK KKPDDLAADD VVNQGGKKKG GGPPYSLLEE AASSGGRRRR EETIIIVTAA VVVVGGGIIK KKPDDLAADD ---------- ---------- ---------- ---------- ---------- ---------- ----MMVVVG GGPPYTLLAA AASSGGSSSS EEKIIIVTAA VVVVGGGIIK KKPDDLAADD NNGACCAAAG GGPPYTLLEE AAEEGGRRRR EEKLLLVTCC VVVVGGGIIK KKPDDLGGDD CCGKHH---G GGPPYSAADD AAKKGGRRRR EEELLLVTAA PPPPAAAAAG GGPDDIFFDN CCPKHH---G GGPPYSAADD AAKKGGRRRR EEELLLVTAA PPPPAAARRG GGPDDIFFNN ---------- ---------- ---------- ---------- ---------- ---------- ---SSSKKKG GGPPYTLLDD AARRGGVVVV EEKLLLVVCC VVVVDDDEEH HHGDDLAADD ---------- ---------- --RRGGRRRR EEKLLLTVTT VVVVDDDEEH HHGDDLSSDD ---------M MMPPLT--DD IIIILLDDDD RRFYYYSNWW LLLLRRRQQD DDITTRKKRV LLAGPPAAAA AADDTQPPYY MMKKTTQQQQ EEEVVVVWTT LLLLMMMGGE EEQDDLVVDR LLAAPPVVVA AADDTAPPYY MMKKTTQQQQ EEDVVVVWTT LLLLVVVGGE EEQDDLVVDN STTYYYYSVV KVLPPYINND ELHFFFGGWN CCCALCCPNK PPNIRRLLII VVGGLLLRSS STTYYYYGII KLLPPYIGGD ELHFFFGGWN CCCAYCCPNK PPFLRRLLII VVAALLLRSS STTYYYYGVV TVMPPNTGGD EFHFFFGGWN CCCSLSSPLH AAFLRRLLII IIGGLLLRSS STTYYYYGVV TVMPPNKGGD EFHFFFGGWN CCCALSSPLH AAFIRRLLII IIGGLLLRSS SKKFFFFGVV QLMPPNKGGD EFHFFFGGWN CCCALSSPLH AAFLRRLLII IIGGIIIRSS SRRYYYYAVV QVMPPHAGGD ELHFFFGGWN CCCCLCCPNH PPHMRRLLVV VVGGLLLRSS STTFFFFGVV VTMPPYTGGG ELHFFFGGWN CCCMLCCPNH PPHVRRLLVV VVDDIIIRSS STTYYYYAVV RVMPPNAAAD ELHFFFGGWN CCCALCCPYH PPHVRRLLII VVGGIIIRSS SQQYYYYSII RLMPPYLKKD ELHSSSGGWN CCCC-----D SSTKRNLLII LLGGLLLMSS SHHYYYYSII RLMPPHLKKD ELHSSSGGWN CCCC-----D SSTKRDLLII LLSSIIIISS SQQYYYYCII RLMPPNLRRD ELHSSSGGWN CCCC-----D SSTKRTLLMM LLCCLLLMSS SQQYYYYCII RLMPPHLKKD ELHSSSGGWN CCCC-----D IITKRTLLVV LLAALLLISS SQQYYYYCII RLMPPNLKKD ELHSSSGGWN CCCC-----D SSTKRTLLVV LLSSLLLISS SQQYYYYCII ---------- ---------- ---------- ---------- ---------- SQQYYYYCII RLMPPNLKKD ELHSSSGGWN CCCC-----D SSTKRTLLVV LLSSLLLISS SQQYYYYCII RLMPPNLKKD ELHSSSGGWN CCCC-----D SSTKRTLLVV LLSSLLLISS SQQYYYYSII RLMPPYLKKD ELHSSSGGWN CCCC-----D SSTKRNLLVV LLSSFFFISS SQQYYYYCII RLMPPNLKKD ELHSSSGGWN CCCC-----D SSTKRTLLVV LLSSLLL--- SQQYYYYCII RLMPPNLKKD ELHSSSGGWN CCCC-----D SSTKRTLLVV LLSSLLLISS STTYYYYSII RLVIIHIGGD KLHSSSGGWN CCCC-----D PPSARRLLII LLSSLLLLSS ---------- --MPPNTNND ELHSSSGGWN CCCC-----D AASKRNLLII LLCCLLLISS SSSYYYYSII RLMPPNVNND ELHSSSGGWN CCCC-----D SSSKRNLLII LLCCLLLISS STTYYYYSII RLVPPYVGGD ELHTTTGGWN CCCC-----D PPSARRLLII AASSLLLVSS STTYYYYSII RLVPPYVGGD ELHTTTGGWN CCCC-----D PPSARRLLII VVGGIIIVSS ---------- --MPPFVGGD ELHSSSGGWN CCCC-----D AASARRLLVV LLSSLLLISS SSSYYYYSII RLMPPFVGGD ELHSSSGGWN CCCC-----D AASVRRLLVV LLSSLLLISS STTYYYYSII RLVTTHVGGD ELHSSSGGWN CCCC-----D PPSARRLLII LLSSLLLLSS STTFFFFCII RVVPPHIGGD EVHTTTGGWN CCCC-----K PPTERSLLII VVCCLLLNSS STTFFFFCII RVVPPNIGGD EVHTTTGGWN CCCC-----K PPTERSLLII VVCCLLLNSS ---------- ---------- ---------- ---------- ------MMVV PPKKLLLSSS STTYYYYCII RTTNNSKHHN ELHSSSGGWN CCCCHFFP-K EEVPRDLLVV LLCCLLLNSS STTYYYYCVV RTTNNRKGGD ELHSSSGGWN CCCCYYYDEK TTVPRDLLVV LLSSLLLNSS VLLGGGGGLL DGVKKVLEED KELSSSQQPT RRRK-----K RRVQGPMMLL QQSSLLLDGG STTRRRRGII SVVGGG-RRN EAHGGGGGFS ---------- ----RRFFWW TTGGLLLDTT SQQYYYYGVV TLVGGG-RRN EAHSSSDDFT ---------- ----RRLLWW AAGGLLLDTT RRIYYYITTT TKNPPEEIII IIIIKVIEPE EKKKVVSSYY YSRRHHHCPP IIYYIIISSS RRIYYYITTT TKDKKRRVVV VVAAKIVEPE VVVGRRTTYY YTKKHHHCPP IIYYIIISSS RRIYYYVTTT TKHPPQQIII IIHHKIIEPD ELLAKKTTYY YSRRHHHCPP IIYYVVVSSS RRIYYYITTT TKDPPKKIII IIHHKIIEPE EFFKKKTTYY YSRRHHHCPP IIYYVVVSSS RRIYYYIVVV VKEPPKKIII IIHHKIIEPE EFFAKKTTYY YSRRHHHCPP IIYYVVVSSS RRIYYYITTT TKDPPKKLLL LLAAKVIEPE TAAERRTTYY YSRRHHHCPP IIYYVVVTTT HHITTTITTT TKDPPQQVVV VVVVKVIDPN EAAERRTTYY YARRHHHCPP IIYYIIISSS RRIHHHITTT TKDPPEEIII IIVVKVIEPE EHHRRRTTYY YSRRHHHCPP VVYYVVVSSS RRIYYYVVVV VGEPPAALLL LLHHKVIEAS EQQAKKCCVV VSNNHHHCAA EEVVMMMVVV RRIYYYVVVV VGEPPAALLL LLHHKVIEPN EHHAKKCCLL LGNNHHHCAA EEVVMMMIII RRIYYYVVVV VGDPPAALLL LLHHKVIEAE DHHAKKCCLL LGYYHHHCAA EEVVMMMIII RRIYYYVVVV VGEPPAALLL LLHHKVIEPK DHHTKKCCLL LGFFHHHCPP EEVVMMMVVV RRIYYYVVVV VGEPPAALLL LLHHKVIEPE DHHAKKCCLL LAFFHHHCAA EEVVMMMIII ---------- ---------- --------PK DHHAKKCCLL LAFFHHHCAA EEVVMMMIII RRIYYYVVVV VGEPPAALLL LLHHKVIEPK DHHAKKCCLL LAFFHHHCAA EEVVMMMIII RRIYYYVVVV VGEPPAALLL LLHHKVIEPK DHHAKKCCLL LAFFHHHCAA EEVVMMMIII RRIYYYVVVV VGEPPAALLL LLHHKVIEAK DHHEKKCCLL LGTTHHHCPP EEVVMMMIII ---------- ---------- ---------- ---------- ---------- ---------- RRIYYYVVVV VGEPPAALLL LLHHKVIEPK DHHAKKCCLL LAFFHHHCAA EEVVMMMIII RRVYYYVTTT TADPPTTLLL LLHHKVVESE DAAENNIILL LGFFHHHCAA DDIIMMMIII RRIYYYVVVV VGDPPAAIII IIHHKTVEPY EFFWKKCCLL LANNHHHCGG EEIIMMMIII RRIYYYVVVV VGDPPAAIII IIHHKTVEPY EFFWKKCCLL LANNHHHCGG EEIIMMMIII RRIYYYVTTT TKNPPSSLLL LLHHKVVDPA DIIQKKTTLL LAYYHHHCAA EELLMMMIII RRVYYYVTTT TKNPPAALLL LLHHKVVEPE DSSTKKTTLL LAYYHHHCAA EEIIMMMIII RRIYYYATTT TKNPPAALLL LLYYKYVDPK EAAEKKTTLL LAYYHHHCAA EEIILLLVVV RRIYYYATTT TKNPPAALLL LLYYKYVDPK EAADKKTTLL LAFFHHHCTT EEIILLLVVV RRVYYYVTTT TLDPPAALLL LLHHKVVEAE DAAEKKTTLL LGFFHHHCAA EEIIMMMIII RRIYYYIVVV VEE--KKLLL LLEEHTIEPS KHHSLLNNLL LSFFHHHCAA NNIIMMMIII RRIYYYVVVV VEE--EELLL LLQQHTIEPS KHHALLNNLL LSFFHHHCAA NNIIMMMIII VVEGGGKVVV VG-------- ---------- ---------- ---------- ---------- RRIFFFVTTT TGDPPAALLL LLAAKVIEG- DLLKGGAACC CTAAHHHCPP NNIIMMMIII FFIYYYIVVV VVDPPKKIII IIVVKTIDG- DLLKSSHHVV VTAAHHHCAA NNIIMMMIII RRLYYYVSSS SLSAADDFFF FFYYP----- DIIKFFLLLL LAIIHHDYPP AALLKKKQQQ RRIFFFIVVV VHDPPNNLLL LLHHKTIDT- FKKDSSGGVV VVGGHHFAPP MMMMIIITTT KKIFFFVVVV VHDPPRRLLL LLSSKTITD- FEEKSSGGVV VVGGHHYAPP MMLLIIITTT AGNE---EGG ---PPGGDHY YFEGGKKEER GQQ------- LAYDWWWNL- VVSSSSWWWA AGGP---DGG RRRPPGGDHD DFEGGRREER GQQ------- FAYDWWWNL- VVTTTTWWWT TGGAGGGDGG TTTAAGGDCE EFDGGRREER GQQ------- KHYDWWWNL- YYSSSSWWWA TGGGGGGDGG TTTPPGGDCE EFEGGRREER GQQ------- LHYDWWWNL- YYTTTTWWWA TGGGGGGDGG TTTPPGGDCE EFEGGRREER GQQ------- KHYDWWWNL- YYSSSSWWWG AGNA---EGG ---PPGGDAQ QFEGGRREER GQQ------- FAYDWWWHL- TTTTTTWWWG AGSP---EGG ---PPGGDHD DLEGGRREER GQQ------- LHYDWWWHL- TTTTTTWWWG AGSP---EGG ---PPGGDHE EFDGGRREER GQQ------- LAYDWWWHL- TTTTTTWWWG NLGD---LQQ GGGKKSSDGE EFEGGTTEEG GSS------- MGYDWWYQP- VVSSSSWWWA SLGD---PQQ GGGKKGGDGE EFEGGTTEEG GAA------- MGYDWWYQP- IISSSSWWWA SLGD---SKK GGGKKGGDGE EFEGGTTEEG GAA------- MGYDWWYQP- VVSSSSWWWA SLGD---PEE GGGKKGGDGK KFEGGTTEEG GAA------- LGYDWWYQP- VVSSSSWWWA SLGD---VKK GGGKKGGDGE EFEGGTTEEG GAA------- SGYDWWYQP- VVSSSSWWWA SLGD---VKK GGGKKGGDGE EFEGGTTEEG GAA------- LGYDWWYQP- VVSSSSWWWA SLGD---VKK GGGKKGGDGE EFEGGTTEEG GAA------- LGYDWWYQP- VVSSSSWWWA SLGD---VKK GGGKKGGDGE EFEGGTTEEG GAA------- LGYDWWYQP- VVSSSSWWWA SLGD---PKK GGGKKGGDGE EFEGGTTEEG GAA------- MGYDWWYQP- VVSSSSWWWA ---------- ---------- ---------- ---------- ---------- ---------- SLGD---VKK GGGKKGGLP- -LEGG----- ---------- ---------- ------SSSA SLGD---KEE GGGAANNLDS SFNGGRRSSL FII------- KERTLLYENY LLSSSSQQQC SIGD---PYY GGGKKGGDGE EFEGGNNEEG EAA------- FGYDWWYQP- VVSSSSWWWG SLGD---PCC GGGKKGGDGE EFEGGNNEEG EAA------- FGYDWWYQP- VVSSSSWWWG SLGD---KDD GGGEENNLDS SFNGGRREEG HPP------- FGYDWWYQP- TTSSSSWWWG SIGD---KDD GGGEENNLDS SFNGGRREEG HPP------- FGYDWWYQP- TTSSSSWWWG SLGD---EEE GGGKKNNLDS SFNNNRREEG HPP------- FGYDWWYQP- TTSSSSWWWG SLGD---EEE GGGKKNNLDS SFNNNRREED IPP------- YGYHWWYQP- TTSSSSWWWG SLGD---KEE GGGAANNLDS SFNGGRREEG HPP------- FGYDWWYQP- TTSSSSWWWG SLGE---ANN GGGSSNNDGK KFEGGTTPPE KVV------- FNYDWWYQP- VVSSSSWWWG SLGE---ADD GGGSSNNDGK KFEGGTTPPG KVV------- FNYDWWYQP- IISSSSWWWG ---------- ---------- ---------- ---------- ---------- --SSSSRRRG SMGD---AEE GGGKK--FDK KFEGGTTSSD RAA------- CGYDWWYQP- VVAAAAWWWG SMGD---AEE GGGKK--FDS SFNGGTTTTD KAA------- CGYDWWYQP- VVSSSSWWWG DVNE---SLL SSSVVNNSKH HNGAAKKEEQ FEE------- LQLSHHNNG- KKSSSSPPPD GSND---DDD HHHRRAANDD DEYTTYYMMA DMMVVDDDAD YGYDRRALI- VVTTTTFFFT GSNN---KDD HHHRRAATNA AEYTTHHIID GLLIT---AD YDYDRRALP- LLTTTTFFFT PPPN-TIIIE EDD-LLKLHH KKD-RRYNNR RIWWWDRKRR KISLTTTGEE ENMAAL---- PPPR-CFFFE EEE-FFSLCC KKEGAAYNNK KLWWWDAKRR RLAIDDDGQQ QHMVVL---- PPPP-QFFFE ENN-IIVPDD LLANKKYHHR RLWWWDRARR RVTIDDDGAA AHMAAL---- PPPP-QFFFE ENN-IIVPDD LLSNKKYHHR RLWWWDRARR RVTIDDDGAA AHMAAL---- PPPP-QFFFE ENN-IIVPDD LLSNKKYHHK KIWWWKRDRR KVTIDDDGAA AHMAAL---- PPPD-MVVVE EDD-LLVPII LLGARRYRRR RLWWWDTRRR RLEIDDDGDD DHLVVF---- PPPR-MVVVE ESS-VVLGEE LLAGKKYHHR RLWWWDYRRR RLTLDDDGAA AYMAAL---- PPPN-MIIIE EGG-LLDPII LLNKGGYRRR RLWWWDRRRR RLALDDDGEE EHMVVL---- PPPN-VFFFK KDDFNNPAVV AA-GLLYSSR RIWWWDQRHH EITLQQQT-- -DLIIP---- PPPN-VFFFK KDDFNNPAVV AA-GLLYSSH HIWWWDQRHH EITLQQQK-- -DLIIP---- PPPN-VFFFR RDDFNNPAVV AA-GLLYSSH HLWWWDQRHH EITLTTTQ-- -DLIIP---- PPPN-VLLLR RDDFNNPAVV AA-GLLYSSH HLWWWDQRRR EVTLPPPQ-- -DLIIP---- PPPN-VLLLR RDDFNNPAVV AA-GLLYSSH HLWWWDQHHH EVTLSSSK-- -DLIIP---- PPPN-VLLLR RDDFNNPAVV AA-GLLYSSH HLWWWDQRHH EVTLSSSK-- -DLIIP---- PPPN-VLLLR RDDFNNPAVV AA-GLLYSSH HLWWWDQRHH EVTLSSSK-- -DLIIP---- PPPN-VLLLR RDDFNNPAVV AA-GLLYSSH HLWWWDQRHH EVTLSSSK-- -DLIIP---- PPPN-VVVVQ QNNFNNPAVV AA-GLLYKKH HLWWWDQRHH EVTLLLLP-- -DHIIP---- ---------- ---------- ---------- ---------- ---------- ---------- SSSN-LRRRL LTTSRRDYAA AA-SRRVGGI IT-------- ---------- ---------- SSSL-FYYYT TTTAEELMLL AA-SGGVVVI ISDDDNIMRR VDSLPPPQ-- -DAGGANNNP PPPK-AFFFA ALLFKKMEVV AA-GMMYHHS SLWWWDTEHH RITIDDDGEE EDLIIP---- PPPK-AFFFA ALLFKKMEVV AA-GHHYHHS SLWWWDTEHH RVTIDDDGKK KDLIIP---- PPPT-AFFFT TKKFDDLQVV DD-GLLYRRH HLIIIQARGG ERTLDDDGNN NTLLLP---- PPPK-AFFFL LQQFNNLQVV DD-GLLYRRH HLYYYSPGGG EKTLDDDGDD DKLLLP---- PPPK-AFFFS SKKFDDLQVV DD-GLLYSSH HLYYYSPGGG EKLIDDDGEE ETLLLP---- PPPK-AFFFS SKKFNNLQVV DD-GLLYSSH HLYYYSPGGG EKLIDDDGPP PTLLLP---- PPPA-AFFFR RTTFDDLQVV DD-GLLYRRH HLYYYDPGGG EKTLDDDGSS STLLLP---- PPPN-HIIIK KKKFNNPAVV EE-GLLYNNS SVFFFEDSKK KLTIDDDPQQ QLALLP---- PPPN-HIIIK KKKFNNPAVV EE-GLLYNNS SVFFFEDTKK KLTIDDDPMM MRALLP---- PPPV-TVVVC CRREEELKQQ EE-PLLVKKC CKYYY----- ---------- ---------- PPPK-LFFFR RRRYHHPTCC DDRTQQYCCR RLYYYRQERR EFTIDDDGDD DDLTTP---- PPPN-KWWWR RRRWKKNVLL DDMSQQYCCR RLYYYKSTQQ TYTIDDDGSS SDITTP---- PPPI-MAAAF FEESEESFKK TTGPLLKQQH HVVVVL---- ---------- ---------- WWWSYMMMMD DFFQMMLQAA AAMKRRFNNT TIWWWDHTRR QKVFNNNPGG GP-------- WWWNYMMMMD DFFKMMLAPP AAMKHHFNNT TVWWWDHTKK QKVFDDDPGG GP-------- -----EELRP LPKKKLLGGF IMMVSLLSSS SSIIW-DKWW WNEEEIIEEP PPGEAVPVTI -----EEVRP LPKKKLLGGF VVVVNLLSSS SSIIW-DKWW WQEEEIIDDP PPGPMVPVTI -----EEVRP APRRREEGGF VVVVDLLEGS SSIIW-GKFF FHKKKAATTP PPAPAVPVTI -----EEVRP APRRREEGGF VVVVDLLEAS SSIIW-GKFF FHEEEAATTP PPKPAVPVTI -----EEIRP APKKKDDGGF CVVVDLLQGA AAIIWKDTFF FEKKKIITTP PPADACPVTI -----EELRP APKKKAAGGF VCCVSLLSSS SSIIW-KKWW WARRRIIEEA AAPPAVPVTI -----EELRP APKKKAAGGF MCCVSLLSAS SSIIW-NSWW WHKKKIIDDP PPEPAVPVTI -----EELRP APRRRTTGGF VVVVSLLSAS SSVVW-NSWW WGRRRIIEEP PPPPAVPVTI ---LLEEIRF LPAAATTGGF VCCASQQRFY YYKKE----- -----TTWWV VVVVEMPITI ---LLEEIRF LPAAATTGGF VCCASQQRFY YYKKG----- -----TTWWV VVVVEMPITI ---LLEEIRF LPAAAAAGGF VCCASQQRFY YYKKG----- -----TTWWV VVVVEMPITI ---LLEEIRF LPAAAAAGGF VCCASQQRFF FFKKD----- -----TTWWV VVVVEMPITI ---LLEEIRF LPAAAAAGGF VCCASQQRFY YYKKG----- -----TTWWV VVVVEMPITI ---LLEEIRF LPAAAAAGGF VCCASQQRFY YYKKG----- -----TTWWV VVVVEMPITI ---LLEEIRF LPAAAAAGGF VCCASQQRFY YYKKG----- -----TTWWV VVVVEMPIT- ---LLEEIRF LPAAAAAGGF VCCASQQRFY YYKKG----- -----TTWWV VVVVEMPITI ---LLEEIRF LPAAASSGGF VCCASQQRFY YYKKG----- -----TTWWV VVVVEMPITI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PIILLCCLRS IKIIINNDDY DVVESRRGGS SSDDA----- -----AAVVK KKLVSLSFPA ---LLEEIRF LPAAAAAGGL VCCASFFRFY YYKKD----- -----KKWWV VVVVEMPITI ---LLEEIRF LPAAADDGGL VCCASFFRFY YYKKD----- -----KKWWV VVVVEMPITI ---LLEEIRF LPKKKDDGGF VSSASIIRFF FFKKD----- -----SSWWA AAVVEMPITF ---LLEEIRF LPKKKDDGGF VSSATIIRFF FFKKD----- -----SSWWV VVVVEMPITF ---LLEEIRF LPKKKDDGGY VSSASIIRFF FFKKD----- -----TTWWV VVVVEMPITF ---LLEEIRF LPKKKDDGGF VSSASIIRFF FFKKD----- -----TTWWV VVVVEMPITF ---LLEEVRF LPKKKDDGGY VCCATVVRFF FFKKD----- -----SSWWA AAIVEMPITF ---LLEEVRF LPSSSEEAAF VCCAGFFRIH HHPPE----- -----TTHHV VVIVEMPITI ---LLEEVRF LPSSSEEAAF VCCAGFFRIH HHPPK----- -----VVQQV VVIVDMPITI ---------- ---------- ---------- ---------- ---------- ---------- ---LLEEIRF LPEEENNGGY VCCAXXXXXX XX-------- ---------- ---GMMGMTI ---LLEEIRF LPKKKAAGGF VCCANFFHFK KKKKD----- -----EEAAD DDGTDMGISI ---------- ---------- ---------- ---------- ---------- ---------- ---LLEEIRF PSAAANNAAF STTATWWLIY YYEEA----- ---------- --WVADIPVI ---LLEEIRC AEHHHNNCCF TTTATWWLIY YYEEE----- ---------- --WVAKVPVI DDILKKFLII IGVVVRQQYS SNNNFKPVVV TTTKKKKKLG FFHRH----- ---------- DDILRRFVLL LGLLLRQQYT TNNNHQPRRR AAARRRKKIG YYHRH----- ---------- DDLLRRFVTT TGMMMRQQYS SDDDHNPVVV AAASSSRRIG AARRH----- ---------- DDLMRRFVTT TGMMMRQQYS SDDDRKPKKK AAASSSHHIG AARRH----- ---------- DDLLKKYVLL LGMMMHQQYS SDDDMNPVVV TTTKKKEEIG VVKKH----- ---------- DDLMRRFVTT TGLLLLQQYS SDDDFEPKKK TTTKKKRRIG VVSRH----- ---------- NNLVRRFVTT TGLLLHQQYS SDDDFNPRRR TTTKKKQQIG VVRRH----- ---------- NNLLRRFVTT TGLLLRQQYS SDDDFNPRRR TTTSSSRRLG VVRKH----- ---------- LLLLRRFFHH HGIIIRQQYS SNNNQKPRRR TTTQQQFFLG IIVRSVLLEQ ELLTCPPPEP LLLLRRFFHH HGIIIRQQYS SNNNKKPRRR TTTQQQFFLG IIVKSVLLEQ ELLTCPPPEP LLLLRRFFHH HGLLLRQQYS SDDDQRPRRR TTTQQQFFLG IIVKPVLLEQ ELLKSPPPEP LLLLHHFFHH HGIIIRQQYS SDDDQRPRRR TTTQQQFFLG IIVKPVLLDQ ELLDSPPPEP LLLLRRFFHH HGLLLRQQYS SDDDQRPRRR TTTQQQFFLG IIVKPVLLEQ ELLKSPPPEP LLLLRRFFHH HGLLLRQQYS SDDDQRPRRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLLLRRFFHH HGLLLRQQYS SDDDQRPRRR TTTQQQFFLG IIVKPVLLEE ELLKSPPPEP LLLLRRFFHH HGMMMRQQYS SDDDKRPRRR VVVQQQFFLG IIVKPVLLEQ ELLKSPPPEP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WWIFLLLF-- ---------- ---------- ---------- ---------- ---------- LLILRRFFHH HGIIIRQQYT TDDDRNPKKK VVVQQQFFLG IILRPVLLEK DLLECPPPDP LLILRRFFHH HGIIIRQQYT TDDDRNPKKK VVVQQQFFLG IIQRPVLLEK ELLECPPPDP LLILRRFFHH HGIIIRQQYE EDDDKNPVVV TTTQQQWWVG IIQKPAIIGD GKKTWSSSDV LLILRRFFHH HGIIIRQQYE EDDDKNPKKK TTTQQQWWAG IIQKPAVVKD GEETWSSSDV LLILRRFFHH HGIIIRQQYE EDDDKNPVVV TTTQQQWWVG LLQKPAVVGD GNNSFFFFDV LLILRRFFHH HGIIIRQQYE EDDDKNPVVV TTTQQQWWVG LLQKPAVVGD GNNTFFFFEV VVILRRYLHH HGIIIRQQYE EDDDAKPVVV AAAQQQWWAG LLQKEYVVTD DKKEEYYYSV LLIMRRFVHH HGIIIRQQYS SDDDLKVKKK NNNQQQYYIG VVHTNVLLEE K----IIIEA LLIMRRFVHH HGIIIRQQYS SDDDKNPKKK NNNQQQFFIG IIHSTVLLED HDD--IIIPA ---------- ---------- ---------- ---------- ---------- ---------- LLILRRYFHH HGVVVRQQYS SDDDANPRRR TTTQQQFFLG IIQRPVLLNP ELLKEPPPEP IIILRRFVHH HGVVVRQQYT TDDDENPKKK TTTQQQFFLG IICSPIVVKK ELLKEPPPPA ---------- ---------- ---------- ---------- ---------- ---------- SSIAQQTIDD DGTTTRLLFS SDDDHKPFFF IIIEEEVVIR VVN------- ---------- SSINSSRVDD DGTTTRLLFS SDDDHHPRRR VVVEEETTIA VVN------- ---------- -----HHKKL LTAAQMMMLL EISSRRGVVY VTTTLSTTWW WDDNQQFFYY YYPPEEEGGK -----AAEEA ATAAQMMMII SVSSRRGVVY ITTTLSSSWW WNNNQQFFYY YYPP---GGR -----RRTTF FAGGQMMMVV EISSRRGVVY WTTTLSTTWW WDDDQQFFYY YYPPDDDGGP -----KKAAF FAGGQMMMVV EISSRRGVVY WTTTLSTTWW WDDDQQFFYY YYPPDDDGGP -----KKTTF FGGGQMMMVV EISSRRGVVY WTTTLSTTWW WDDEQQFFYY YYPPGGGDDG ----AGGAAL LNGGQMMMVV EISSRRGVVY FTTTLGAAVV VDDPQQFFYY YYPPEEEGGD ----AAAEEL LNGGQMMMVV EISSRRGVVY FTTTLRAAWW WDDEQQFFYY YYPPDDDGGK -----GGPPL LNGGQMMMVV EVSSRRGVVY FSSSLASSWW WDDEQQFFYY YYPPVVVGGR PPVVVKKRRI IPGGQMMMII QLSSLLGLLY ATTTLSDDWW WDDKQQFFYY YY--PPPDDI PPVVVKKRRV VPGGQMMMII QLSSLLGLLY VTTTLSAAWW WDDKQQFFYY YY--PPPNNI PPVVVKKKKV VPGGQMMMII QLSSLLGLLY VTTTLSAAWW WDDKQQFFYY YY--PPPDDI PPVVVKKQQV VAGGQMMMII QLSSLLGLLY VTTTLSAAWW WDDKQQFFYY YY--PPPDDI PPVVVKKRRV VAGGQMMMII QLSSLLGLLY ITTTLSAAWW WDDKQQFFYY YY--PPPDDI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPVVVKKRRV VAGGQMMMII QLSSLLGLLY ITTTLSAAWW WDDKQQFFYY YY--PPPDDI PPVVVKKRRV VPGGQMMMII QLSSLLGIIY VTTTLSDDWW WDDKQQFFYY YY--PPPDDI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPIIVKKKKV VPGGQMMMII QLSSLLGLLY VTTTLSKKWW WDDKQQFFYY YY--PPPDDI PPTTVKKIII IPGGQMMMII QLSSLLGIIY VTTTLSIIWW WDDKQQFFYY YY--PPPDDL VVEEIQQKKL LRGGQMMMII QLTTLLGLLY VTTTLSAAWW WDDKQQFFYY YY--PPPGGV VVEEIKKKKL LRGGQMMMII QLSSLLGLLY VTTTLSAAWW WDDKQQFFYY YY--PPPKKV VVQQIKKSSL LRGGQMMMII QLSSLLGLLY ATTTLSAAWW WDDRQQFFYY YY--PPPEEM VVQQIKKSSL LRGGQMMMII QLSSLLGLLY ATTTLSAAWW WVVVSSFFYY YY--PPPEEM VVQQVHHRRL LRGGQMMMII QLSSLLGIIY VTTTLSRRWW WDDEQQFFYY YYGGQQQDDV AAYYVRRKKI IEGGQMMMLL QLSSLLGLLY VTTTLKKKWW WDDDQQFFYY YY--PPPEEV AAYYVRRQQI IEGGQMMMLL QLSSLLGLLY VSSSLKKKWW WDDDQQFFYY YY--PPPEEV ---------- --GGAKKKII QLSSVVGLLY VTTTFSTTWW WDDKQQFFYY YY--PPPNNV PPFFLRRRRL LLGGQMMMLL QLSSLLGLLY VSSSLSPPWW WDDKQQFFYY YY--PPPEEV AAYYVRRRRL LEGGQMMMLL QLSSLLGLLY VSSSLSPPWW WDDKQQFFYY YY--PPPKKV ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMMVV SQSSWWGVVY FSSSLANNWW WDD------- ---------- ---------- -----MMMVV SSSSWWGLLY YTTTLANNWW WDD------- ---------- GGGWMVLAAN N------PSG GLLLLEEDKF DDFFGGEE-R VRLSGGSDSC CCP------- GGGWMAVVVN N------PEG GLLLLEEEKF DDFFGGRR-R VRLWGGTDSC CCP------- AAAAQVAAAG G------PDG GLLLLTTADY EEFFPPDDGR IRLEGGTDSC CCPKK----- GGGVEVAVVG G------GNG GLLLLEEDKY SSFFPPDDGR IRLEGGTDSC CCP------- AAAAMVAVVG G------ENG GLLLLTTDKF DDFFPPAAGR IRLEGGTDSC CCP------- GGGWMVLAAG G------PNG GIIIIEEDPF EEWWPPKKGR VRLQGGSDSC CCP------- GGGWMVVVVN N------PDG GMMMMQQDPF DDFFGGEE-R IRLQGGSDSC CCP------- GGGWIAAAAD D------PGG GLLLLSSDPF EEVVGGDDGR IRLEGGSDSC CCP------- RRREGSMQQV VDVDTTTVNG GLLLLKKNPF DDFFGGKKEL LRYPGGSDII II-------- RRREGSMQQI IDVDTTTANG GLLLLKKNPF DDFFGGKKEL LRYPGGSDII II-------- RRREGSMQQI IDVDTTTVKG GLLLLKKNPF DDFFGGKKEL LRYPGGSDIL LL-------- RRREGSMQQI IDVDTTTVKG GLLLLTTNPF DDFFGGKKEL LRYPGGSDIL LL-------- RRREGSMQQV VDVDTTTVKG GLLLLKKNPF DDFFGGKKEL LRYPGGSDII II-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRREGSMQQV VDVDTTTVKG GLLLLKKNPF DDFFGGKKEL LRYPGGSDII II-------- RRREGSMQQI IDVDTTTVKG GLLLLKKNPF DDFFGGKKEL IRYPGGSDIL LL-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKKEGSMQQI IDVDTTTEKG GLLLLKKNPF DDFFGGKKEL LRYPGGSDIV VV-------- KKKEGAMQQI IDVDTTTKKG GLLLLKKNPF DDFFGGKKEL IRYPGGSDII II-------- EEEKGSIQQI IDVDTTTEKG GLLLLKKNPF DDFFGGAAEL MRYPGGSDII II-------- EEEQGSIQQI IDVDTTTENG GLLLLKKNPF DDFFGGAAEL MRYPGGSDII II-------- DDDKGSIQQI IDVDTTTEKG GLLLLSSNPF DDFFGGDDEL MRYPGGSDII II-------- EEEKGSIQQI IDGDTTTEKG GLLLLTTNPF DDFFGGDDEL MRYPGGSDII II-------- KKKKGSMQQI IDVDTTTEKG GLLLLSSNPF DDFFGGAAEL MRYPGGSDII II-------- KKKSGAMQQV VNIDPPPESG GMMMMEENRF DDFFGGKKIL MRYPGGSDII II-------- RRRSGAMQQI IDVDPPPITG GMMMMVVNKF DDFFGGKKVL MRYPGGSDII II-------- KKKEGSMQQI IDVDTTTEKG GLLLLTTNKF DDFFGGKKEL IRFPCCSDIA AA-------- AAAAGGIQQL LDIDVVVENG GMMMMKKNEF DDFFGGGGEL MR-------- ---------- SSSQGGILLI IDVDTTTVNG GIIIISSNEF DDFFAANNEL MRYPGGSDIL LLN------- ---------- ---------- ---------- ---------- ---------- ---------- KKKKGKDQQY YLKAYYYNWD DKKKKEEVEF DDFFYYEELR MRFGSSSS-- ---------- KKKKGKDQQF FLKLYYYYWD DKKKKEEKEF DDFFYYAAER MRFGAAAGPG GGGLLQAARR ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- RRVVEEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNNSAKAAQ QEAATTPCRT TTTAVVPTTT GGLAAAARAA GGMSLPRRTA AQQLSSPSIK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKKAAYYYQE AAWTTFSSAI IVLASSPPRS KKKKKKRGLL VVIISSAAAV AAQQVVVPPS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMMAG RSAPPTLPPL LNRTTTPPHP LLLLAAPRVV PPTTRLVVVR PPRRTIINNV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------IPFF KDDPFFFYPS ---------- ---------- ---------- ---------- ------MKLL KDDPFFFYPT ---------- ---------- ---------- ---------- -------SMM RDDPFFFHAS ---------- ---------- ---------- ---------- -------TMM RDDPFFFHAS ---------- ---------- ---------- ---------- -------TLL RDDPFFFYPS ---------- ---------- ---------- ---------- ------MTWW KDDPFFFYPS ---------- ---------- ---------- ---------- ------MTWW RDDPFFFYPS ---------- ---------- ---------- ---------- ------MSWW RDDPFFFYPS ---------- ---------- ---------- ---------- ----MMCK-- -GGPYYYPTP ---------- ---------- ---------- ---------- ---------- ---------- SSQQAAVWWW WHHWWLLPPP KHGAAVLIII PARRRRGGGL PG-AHHCK-- -GGPYYYPSP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMCN-- -GGPYYYSTP ---------- -------AAE AEGAFTLQQQ VAQQQQPPPR PIASTTCN-- -GGPYYYSTP ---------- ---------- ---------- ---------- ----MMCN-- -GGPYYYSTP ---------- ---------- ---------- ---------- ----MMCN-- -GGPYYYSTP ---------- -MMGGLLGGK EPGHTAQPPP FLSSSSGGGL WQEDTTCD-- -GGPYYYPTP -------LLL LKKNNSSQQG LGFDQTNTTT LHTTTTYYYT LVFTSSCN-- -GGPYYYSTP ---------- ---------- ---------- ---------- ----MMCN-- -GGPYYYSTP VVPPPRLCCC CPPHHAARRH LVLQHIMEEE AAAAAAVVVT AAAANNCHTT AGGPYYYATP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------CS-- -GGPYYYKSP ---------- ---------- ------MAAA VLDDDDHHHV VNEKKKNCCC KGGPYYYASP ---------- ---------- ------MGGG VLQQQQHHHV VSEKVVQCCC KGGPYYYASP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------RLQQ VGGPYYYATP ---------- ---------- ---------- ---------M AAAANNCGGG AGGPYYYATP ---------- ---------- ---------- ---------- MSPNCCCG-- -GGPYYYASP ---------- ---------- ---------- ---------- MP--CCCG-- -GGPYYYASP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------EKCC KGGPYYYATP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMPLLLIT- ---------- -----MMKKR EFG------- ------AAAA AG-ALLLFRR AAADTTTCQS ---------- -----MMKKR IVSGPSMHHH ALRRRRAAAV SGLALLAAGG VAADTTTCAS PPPMAMMMKK KAPPEYVVAC LYGGGGGINR RADDDFVVDS ETVHKKKKVV VLIINNDDDE PPPDAMMMRR RAPPEYVVAA LYGGGGGVNA APDDDFVVDS PTIYKKKKLL LLIIGGDDDE PPPLAMMMQQ QAAAEYTTLL LSDDSSS--R RPDDDAIIDS STVHTTTTVV VMTTGGDDDE PPPLAMMMEE EAAAEYTTLL LSDDSSS--K KPDDDAIIDS PTVHTTTTVV VMKKGGDDDE AAALAMMMEE EGVVEFTTLM LSDDSSS--K KPDDDGVVDS EKVHQQQQLL LMKKGGDDDE PPPLAAAAKK KAPPEYVVAM FDEEKKK--Q QPDDDAVVDS PRVGQQQQVV VMAAGGDDDE PPPMAVVVKK KAAAEYVVVR LNMMNNNG-K KPDDDAVVDS STVGVVVVTT TMTTGGGGGE PPPMAMMMQQ QARREYVVAL LDGGEEE--R RPDDDALLDS GTVGRRRRVV VMAAAADDDE LLLAMKKK-- -GRREYLLPC IYNNGGGTEA APDDDYVVDS PQIHRRRRLL LMLLKKDDDE -----MMM-- -GRREYLLPC IYNNGGGIEA APDDDYVVDS PHIHRRRRLL LMLLKKDDDE LLLAMKKK-- -GRREYLLPC IYNNGGGIEA APDDDYVVDS PQIHRRRRLL LMLLRRDDDE ----MKKK-- -GRREYLLPC IYNNGGGIEA APDDDYVVDS PQIHRRRRLL LMLLKKDDDE LLLAMKKK-- -GRREYLLPC IYNNGGGTEA APDDDYVVDS PQIHRRRRLL LMLLKKDDDE LLLAMKKK-- -GRREYLLPC IYNNGGGTEA APDDDYVVDS PQIE------ ---------- LLLAMKKK-- -G-------- -------TEA APDDDYVVDS PQIHRRRRLL LMLLKKDDDE LLLAMKKK-- -GRREYLLPC IYNNGGGTEA APDDDYVVDS PQIHRRRRLL LMLLKKDDDE QQQAMKKK-- -GRREYLLPC IYNNGGGTEA APDDDYVVDS PQIHRRRRLL LMLLKKDDDE LLLAMKKK-- -GRREYLLPC IYNNGGGTEA APDDDYVVDS PQIHRRRRLL LMLLKKDDDE LLLAMKKK-- -GRREYLLPC IYNNGGGTEA APDDDYVVDS PQIHRRRRLL LMLLKKDDDE LLLAMEEEKK KGRREYVVTC VYGGGGGINK KLDDDYVVDS PTIHRRRRLL LVIIGGDDDK ---------- ---------- ---------- ---------- ---------- -MTTNNDDDE LLLAMKKK-- -GRREYLLPC IYSSGGGINK KPDDDYVVDS PSIHRRRRLL LMVVNNDDDE IIISMSSS-- -GRREYVVTA VYGGGGGIEK KPDDDYVVDS PTIHRRRRLL LVVVGGDDDE LLLAMSSS-- -GRREYVVTA VYGGGGGIEK KPDDDYVVDS PTIHRRRRLL LVVVGGDDDE ---------- ---------- ---------- ---------- ---------- -MVVGGDDDE LLLAMSSS-- -GSSEYVVTA VYGGGGGIDK KPDDDYVVDS PSIHRRRRLL LMVVGGDDDE LLLAMEEEKK KGRREYVVTC VYGGGGGINK KPDDDYVVDS PTIHRRRRLL LVVVGGDDDE AAAAIKKK-- -GRREFVVTA P---AAAADG GPDDDAVVDS DTISRRRRVV VVIIGGDDDE AAAAIKKK-- -GRREFVVTA P---AAARDG GPDDDAVVNS ETISRRRRVV VVIIGGDDDE ---------- ---------- ---------- ---------- ---------- ---------- LLLAVRRRNN NGVVEYVVVC VQNNDDDEEH HGDDDYVVDS PTIHRRRRTT TTKKHHNNNE ----MRRRSS SGRREYTTVT VQNNDDDEPH HGDDDYVVDS PTVHRRRRTT TTKKGGDDDE ---ILIIISS SLDDRFSSNW LHDDRRRQYD DITTTDPPRV FLLKDDDDGG GVLLEEDDDK PPPMPKKKII ITQQEYVVWT LGEEMMMGDE EQDDDKIIDS ATINSSSSVV VV--RRNNNE PPPMKKKKII ITQQEYVVWT LGEEVVVGDE EQDDDKVVDS PQVNTTTTLL LV--RRNNNE LHHFWWNACC SSL--PPPGK PNRRRRLVRS RKNPREPKKK IKKVVIIEEE PEEEEVVVKK LHHFWWNACC SSY--PPPAK PFRRRRLVRS RKDKRRPAAA AKKIIVVEEE PEEVVAAAVG FHHFWWNACC SSL--PPPTH AFRRRRLIRS RKHPTQARRR HKKIIIIEEE PDDEEIIILA FHHFWWNACC SSL--PPPAH AFRRRRLIRS RKDPTKAKKK HKKIIIIEEE PEEEEVVVFK FHHFWWNACC SSL--PPPTH AFRRRRLIRS RKEPLKAKKK HKKIIIIEEE PEEEEVVVFA LHHFWWNACC SSL--PPPAH PHRRRRLVRS RKDPLKPFFF AKKVVIIEEE PEETTLLLAE LHHFWWNACC SSL--PPPAH PHRRRRLVRS HKDPTQPKKK VKKVVIIDDD PNNEELLLAE LHHFWWNACC AAL--PPPAH PHRRRRLVRS RKDPREPRRR VKKVVIIEEE PEEEELLLHR LHHSWWNTCC SS------FD STRRRNLLMS RGEPRAPKKK HKKVVIIEEE ASSEEIIIQA LHHSWWNTCC SS------FD STRRRDLLIS RGEPRAPKKK HKKVVIIEEE PNNEEIIIHA LHHSWWNACC SS------FD STRRRTLLMS RGDPRAPKKK HKKVVIIEEE AEEDDIIIHA LHHSWWNTCC SS------YD ITRRRTLLIS RGEPRAPKKK HKKVVIIEEE PKKDDIIIHT LHHSWWNTCC SS------FD STRRRTLLIS RGEPRAPKKK HKKVVIIEEE PEEDDIIIHA ---------- ---------- ---------- ---------- ---------- PKKDDIIIHA LHHSWWNTCC SS------FD STRRRTLLIS RGEPRAPKKK HKKVVIIEEE PKKDDIIIHA LHHSWWNTCC SS------FD STRRRTLLIS RGEPRAPKKK HKKVVIIEEE PKKDDIIIHA LHHSWWNTCC SS------FD STRRRNLLIS RGEPRAPKKK HKKVVIIEEE AKKDDIIIHE LHHSWWNTCC SS------FD STRRRTLL-- ---------- ---------- ---------- LHHSWWNTCC SS------FD STRRRTLLIS RGEPRAPKKK HKKVVIIEEE PKKDDIIIHA LHHSWWNSCC SS------HD PSRRRRLLLS RADPRTPSSS HKKVVVVEEE SEEDDIIIAE LHHSWWNTCC SS------YD ASRRRNLLIS RGDPRAPRRR HKKTTVVEEE PYYEEVVVFW LHHSWWNTCC SS------YD SSRRRNLLIS RGDPRAPRRR HKKTTVVEEE PYYEEVVVFW LHHTWWNSCC SS------HD PSRRRRLAVS RKNPRSPSSS HKKVVVVDDD PAADDIIIIQ LHHTWWNSCC SS------HD PSRRRRLVVS RKNPRAPSSS HKKVVVVEEE PEEDDIIIST LHHSWWNSCC SS------HD ASRRRRLLIS RKNPRAPSSS YKKYYVVDDD PKKEEIIIAE LHHSWWNSCC SS------HD ASRRRRLLIS RKNPRAPSSS YKKYYVVDDD PKKEEIIIAD LHHSWWNACC SS------HD PSRRRRLLLS RLDPRAPAAA HKKVVVVEEE AEEDDIIIAE VHHTWWNACC SS------HK PTRRRSLVNS REE-RKIYYY EHHTTIIEEE PSSKKLLLHS VHHTWWNACC SS------HK PTRRRSLVNS REE-REIYYY QHHTTIIEEE PSSKKLLLHA ---------- ---------- ------MPSS VG-------- ---------- ---------- LHHSWWNTCC SSHVVPPPGK EVRRRDLLNS RGDPRAPKKK AKKVVIIEEE G--DDVVVLK LHHSWWNACC SSYVVDDDSK TVRRRDLLNS FVDPRKPEEE VKKTTIIDDD G--DDVVVLK ELDSPPTPRR LL-------K RVGGGPMQDG RLSAWDKQQQ YPP------- ---DDLLLIK AHHGFFSA-- ---------- --RRRRFTDT RHDPSNPKKK HKKTTIIDDD T--FFVVVKD AHHSFFTD-- ---------- --RRRRLADT KHDPARPVVV SKKTTIITTT D--FFVVVEK VSSGGGYYSS STHHCGGPPD AIIYISSGE- G-PPGGGGIM DDHYEEPLGK IGGDYY---- RTTGGGYYTT TTHHCGGPPD AIIYISSGP- GRPPGGGGIL DDHDEEPIGR VGGPYY---- KTTGGGYYSS STHHCGGPPE GIIYVSSGAK GTAAPPGGII DDCEDDVLGR IGGPDD---- KTTGGGYYSS STHHCGGPPD GIIYVSSGGK GTPPPPGGVI DDCEEEVLGR IGGPTT---- KTTGGGYYSS STHHCGGPPE GIIYVSSGGE GTPPPPGGII DDCEEEILGR MGGETT---- RTTGGGYYSS STHHCGGPPG GIIYVTTGA- G-PPGGGGIM DDAQEEPLGR VGGPYY---- RTTGGGYYAA ATHHCGGPPD GIIYISSGP- G-PPGGGGII DDHDEEVLGR IGGDYY---- RTTGGGYYSS STHHCGGPPD GVVYVSSGP- G-PPGGGGVV DDHEDDPLGR VGGPQQ---- KCCNNNVVSS STHHCLLAAS GEEVMVVLD- QGKKGGSSFL DDGEEEVKGT KGGAPP---- KCCNNNLLGG GTHHCLLAAS GEEVMIILD- QGKKGGGGFL DDGEEEVKGT KGGEPP---- KCCGGGLLGG GTHHCLLAAS GEEVMIILD- KGKKGGGGFL DDGEEEVKGT QGGAPP---- KCCNNNLLGG GTHHCLLPPS GEEVMVVLD- EGKKGGGGFL DDGKEEVKGT QGGAPP---- KCCEEELLAA ATHHCLLAAS GEEVMIILD- KGKKGGGGFL DDGEEEVKGT RGGAPP---- KCCEEELLAA ATHHCLLAAS GEEVMIILD- KGKKGGGGFL DDGEEEVKGT RGGAPP---- KCCEEELLAA ATHHCLLAAS GEEVMIILD- KGKKGGGGFL DDGEEEVKGT RGGAPP---- KCCEEELLAA ATHHCLLAAS GEEVMIILD- KGKKGGGGFL DDGEEEVKGT RGGAPP---- KCCGGGLLGG GTHHCLLPPT GEEVMIILD- KGKKGGGGFL DDGEEEVKGT RGGSPP---- ---------- ---------- ---------- ---------- ---------- ---------- KCCEEELLAA ATHHCLLAAS GEEVMIILD- KGKKDDGGSV LLP-EECSG- ---------- NIIGGGLLGG GTHHCLLAAS GDDIMIILD- EGAAGGNNGL LLDSNNVKGR NFFPSS---- KCCGGGLLAA ATHHCLLGGC GEEIMIIID- YGKKGGGGFL DDGEEEVKGN AEEAPP---- KCCGGGLLAA ATHHCLLGGC GEEIMIILD- CGKKGGGGFL DDGEEEVKGN VEESQQ---- KTTGGGLLAA ATHHCLLAAS GEELMIILD- DGEEGGNNGL LLDSNNVKGR KHHSLL---- KTTGGGLLAA ATHHCLLAAS GEEIMIIID- DGEEGGNNGL LLDSNNVKGR KHHSLL---- KTTGGGLLAA ATHHCLLAAS GEEILVVLD- EGKKGGNNGL LLDSNNIKNR KHHSLL---- KTTGGGLLAA ATHHCRRTT- GEEILVVLD- EGKKGGNNGL LLDSNNIKNR KIISLL---- KTTGGGLLGG GTHHCLLAAS GEEIMIILD- EGAAGGNNGL LLDSNNVKGR KHHSLL---- LNN---LLSS STHHCLLAAD GNNIMIILE- NGSSGGNNFL DDGKEEPKGT AKKTPP---- LNN---LLSS STHHCLLAAD GNNIMIILE- DGSSGGNNFL DDGKEEPKGT AKKVPP---- ---------- ---------- ---------- ---------- ---------- ---------- GAADDDCCTT TTHHCLLPPN GNNIMIIMD- EGKKGG--DV FFDKEELVGT RRRKLL---- SHHNNNVVTT TTHHCLLAAN GNNIMIIMD- EGKKGG--DI FFDSNNCIGT KKKKLL---- FLLVVVLLAA ATDDYQQPPN TAALKQQVE- LSVVLLNNGQ SSKHGGLSAK AFFEII---- SGGGGGVVVV VTFFALLPPG SMMMITTSD- DHRRTTAALE NNDDYYVATY PDDDQQAAVV SGGGGGVVVV VTYYALLPPG RMMLITTSN- DHRRTTAALE TTNAYYVATH PGGDRRAATT ---------L AYYDWPNELL LSSEAV-IGG LEHHLKDRNR RHFWLKKKKI SSTTLGENMM ---------F AYYDWPSGMM MTSETV-FGG LECCLKEANK KHVWLKRRRL AADDLGEHMM ---------K HYYDWPRDMM MSSEAL-FGG PEDDLLAKHR RHFWLARRRV TTDDLGQHMM ---------L HYYDWPRDMM MTSEAL-FGG PEDDLLSKHR RHFWLARRRV TTDDLGNHMM ---------K HYYDWPRDMM MSSEGL-FGG PEDDLLSKHK KHFWLDKKKV TTDDLGNHMM ---------F AYYDWGYDLL LTSEGT-VGG PDIILLGRRR RHFWLRRRRL EEDDFGEHLL ---------L HYYDWGYDLL LTSEGT-VGG GDEELLAKHR RHVWLRRRRL TTDDLGEYMM ---------L AYYDWGYDMM MTSEGT-IGG PQIILLNGRR RHIWLRRRRL AADDVGEHMM ---------M GYYDWRHNMM MSTEAA-FGG AHVVEA-LSR RFVWWREEEI TTQQMT-DLL ---------M GYYDWRHNMM MSTEAA-FGG AHVVEA-LSH HHVWWREEEI TTQQMK-DLL ---------M GYYDWRHNMM MSTEAA-FGG ADVVEA-LSH HHVWWREEEI TTTTLQ-DLL ---------L GYYDWRHNMM MSTEAA-LGG ADVVKA-LSH HYVWWREEEV TTPPLQ-DLL ---------S GYYDWRHNMM MSTEAA-LGG ADVVEA-LSH HYVWWHEEEV TTSSLK-DLL ---------L GYYDWRHNMM MSTEAA-LGG ADVVEA-LSH HYVWWREEEV TTSSLK-DLL ---------L GYYDWRHNMM MSTEAA-LGG ADVVEA-LSH HYVWWREEEV TTSSLK-DLL ---------L GYYDWRHNMM MSTEAA-LGG ADVVEA-LSH HYVWWREEEV TTSSLK-DLL ---------M GYYDWRHNMM MSTEAA-VGG ADVVEA-LKH HHVWWREEEV TTLLMP-DHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AIAH-RGG YPAASA-RGI I--------- ---------- ---------K ERRTLAWGFF FSWICC-YGG MCLLTA-GVI ICLDYMVVVD SSPPLQ-DAA ---------F GYYDWRHNMM MSTEGA-FGG EEVVQA-MHS SNVWWERRRI TTDDLG-DLL ---------F GYYDWRHNMM MSTEGA-FGG EDVVQA-HHS SNVWWERRRV TTDDLG-DLL ---------F GYYDWRHNMM MSTSGA-FGG QHVVAD-LRH HTCILREEER TTDDLG-TLL ---------F GYYDWRHNMM MSTSGA-FGG QHVVAD-LRH HHVYWGEEEK TTDDLG-KLL ---------F GYYDWRHKMM MSTSGA-FGG QHVVAD-LSH HHVYWGEEEK LLDDLG-TLL ---------Y GYYHWRHKMM MSTSGA-FGG QHVVAD-LSH HHVYWGEEEK LLDDLG-TLL ---------F GYYDWRHKMM MSSSGA-FGG QHVVQD-LRH HHVYWGEEEK TTDDLG-TLL ---------F NYYDWRRNMM MSTEGS-IGG AHVVGE-LNS SHIFWSKKKL TTDDLPPLAA ---------F NYYDWRRNMM MSTEGS-IGG AHVVPE-LNS SHIFWTKKKL TTDDLPPRAA ---------- ---------- -SILGG-VDD KCQQPE-LKC CRVY------ ---------- ---------C GYYDWHFNMM MASEGA-FGG TDCCDDRQCR RNFYWEEEEF TTDDLG-DLL ---------C GYYDWYFDMM MSSEGA-WGG VDLLEDMQCR RNFYWTTTTY TTDDLG-DII ---------L QLLSH-RESS SSDRDE-ASS FLKKKTGLQH HAEV------ ---------- AVVAADDGGY GYYDRRKNMM MTSSTGNMGG QDAAEAMRNT TVQWLTQQQK VVNNVPAP-- KYYAADDGGY DYYDRRKNLL LTSSTGNMGG ADPPEAMHNT TVTWLTQQQK VVDDVPAP-- M------ELR PPPPKKLMGF MMVVVVSLLL SSSIWLLLLL FF--DDGKKV IEPAAAEEPL M------EVR PPPPKKLMGF VVVVLLNTTT SSSIWLLLLL FF--DDGKKV IDEAAAQQPF M------EVR PPPPRREYGF VVVVVVDTTT ESSIWTTTTT WW--GGGKKT ATPAAAEEPA M------EVR PPPPRREYGF VVVVVVDTTT ESSIWTTTTT WW--GGGKKT ATPPPPEEPA M------EIR PPPPKKDYGF VVVVVVDTTT QAAIFTTTTT WWKKDDGTTT ITDPPPVVPA L------ELR PPPPKKAYGF CCVVIISLLL SSSIWTTTTT YY--KKDKKV IEPAAAEEAA M------ELR PPPPKKAYGF CCVVVVSLLL SSSIWLLLLL YY--NNGSSV IDPAAAEEPA M------ELR PPPPRRTYGF VVVVVVSLLL SSSVWLLLLL HH--NNGSSV IEPAAAEEPA L------EIR FPPPAATQGF CCAALLSSSS RYYKNEEEEE GG-------- TWVEEEKKVI L------EIR FPPPAATQGF CCAALLSSSS RYYKNEEEEE GG-------- TWVEEEKKVI L------EIR FPPPAAAQGF CCAALLSSSS RYYKNQQQQQ GG-------- TWVEEEKKVI L------EIR FPPPAAAQGF CCAALLSSSS RFFKNEEEEE GG-------- TWAQQQKKVI L------EIR FPPPAAAQGF CCAALLSSSS RYYKNEEEEE GG-------- TWVEEEKKVI L------EIR FPPPAAAQGF CCAALLSSSS RYYKNEEEEE GG-------- TWVEEEKKVI L------EIR FPPPAAAQGF CCAALLSSSS RYYKNEEEEE GG-------- TWVEEEKKVI L------EIR FPPPAAAQGF CCAALLSSSS RYYKNEEEEE GG-------- TWVEEEKKVI H------EIR FPPPAASQGF CCAALLSSSS RYYKNEEEEE GG-------- TWVEEEKKVI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ANNNNNPCLR SKKKIINQDY VVEEVVSFFF GSSDPDDDDD YY-------- AVLKKKRRKL L------EIR FPPPAAAQGL CCAALLSSSS RYYKEKKKKK GG-------- KWAEEEKKVI L------EIR FPPPAADQGL CCAALLSSSS RYYKEKKKKK GG-------- KWAEEEKKVI L------EIR FPPPKKDTGF SSAALLSSSS RFFKTQQQQQ GG-------- SWHEEELLAI L------EIR FPPPKKDTGF SSAALLTSSS RFFKTQQQQQ GG-------- SWHEEEIIVI L------EIR FPPPKKDTGY SSAALLSSSS RFFKNSSSSS DD-------- TWYEEEIIVI L------EIR FPPPKKDTGF SSAALLSSSS RFFKNSSSSS EE-------- TWHEEEVVVI L------EVR FPPPKKDTGY CCAALLTSSS RFFKTAAAAA GG-------- SWHEEEVVAI A------EVR FPPPSSEHAF CCAALLGSSS RHHPVEEEEE NN-------- THATTTLLVA A------EVR FPPPSSEHAF CCAALLGSSS RHHPDEEEEE NN-------- VQASSSLLVA ---------- ---------- ---------- ---------- ---------- ---------- L------EIR FPPPEENQGY CCAAFFXXXX XXX------- ---------- ---------- I------EIR FPPPKKAEGF CCAALLNAAA HKKKKSSSSS SS-------F EAKVVVIIDI ---------- ---------- ---------- ---------- ---------- ---------- -------EIR FSSSAANYAF TTAALLTSSS LYYEDDDDDD GG-------- ---------- -------EIR CEEEHHNYCF TTAALLTSSS LYYEDGGGGG GG-------- ---------- EEEE-NLPEE IKKKKPPPVT TTDIIISLLD DKFLYYLLSS WIIQYYDDIF KKKPPVTVVV EEEE-PLPPP VKKKKPPPVT TTDIIISLLD DRFLYYVVSS WLLQYYDDIH QQQPPRAVVV TTTTDELPPP LQQQGPPPVT TTDILLSLLD DRFLYYVVSS WTTQYYDDVH NNNPPVAVVV PPPPEKLPPP LQQQGPPPVT TTDILLSMMD DRFLYYVVSS WTTQYYDDVR KKKPPKAVVV DDDDDDLPDD LKKKGPPPVT TTDILLSLLD DKYLYYVVAA WLLQYYDDVM NNNPPVTVVV DDDDDQLPPP VKKKKPPPVT TTDILLSMMD DRFLYYVVSS WTTQYYDDVF EEEPPKTVVV SSSSDQLPPP IKKKKPPPVT TTDILLSVVD DRFLYYVVSS WTTQYYDDVF NNNPPRTVVV EEEEDQLPPP LKKKGPPPVT TTDILLSLLD DRFLYYVVSS WTTQYYDDVF NNNPPRTVVV QQQQPSKKVV KWWWPPGGIT TTDILLSLLD DRFLYYFFSS WHHQYYDDIQ KKKPPRTIII QQQQPSKKVV KWWWPPGGIT TTDILLSLLD DRFLYYFFSS WHHQYYDDIK KKKPPRTIII QQQQPPKKVV KWWWPPGGIT TTDILLSLLD DRFLYYFFSS WHHQYYDDIQ RRRPPRTLLL QQQQPPKKVV KWWWPPGGIT TTDILLSLLD DHFLYYFFSS WHHQYYDDVQ RRRPPRTLLL QQQQPPKKVV KWWWPPGGIT TTDILLSLLD DRFLYYFFSS WHHQYYDDIQ RRRPPRTLLL QQQQPPKKVV KWWWPPGGIT TTDILLSLLD DRFLYYFFSS WHHQYYDDIQ RRRPPR---- QQQQPPKKVV KWWWPPGGIT TT-------- ---------- ---------- ---------- QQQQPPKKVV KWWWPPGGIT TTDILLSLLD DRFLYYFFSS WHHQYYDDIQ RRRPPRTLLL EEEEPPKKVV KWWWPPGGIT TTDILLSLLD DRFLYYFFNN WHHQYYDDIK RRRPPRVIII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDDDYYAVVV AFFFVSNNFP PPPAIIFFFD DLLIIIFFLL ---------- ---------- KKKKPSKKVV EWWWPPGGIT TTDIIISLLD DRFLYYFFSS WHHQYYDDIR NNNPPKVIII QQQQPSKKVV EWWWPPGGIT TTDIIISLLD DRFLYYFFSS WHHQYYDDIR NNNPPKVIII PPPPKPLKVV QWWWPPGGIT TTDFIISLLD DRFLYYFFVV WHHQYYNNIK NNNPPVTLLL SSSSEPLKVV QWWWPPGGIT TTDFIISLLD DRFLYYFFVV WHHQYYNNIK NNNPPKTVVV SSSSKPLKVV EWWWPPGGIT TTDFIISLLD DRFLYYFFVV WHHQYYNNIK NNNPPVTIII SSSSKPLKVV EWWWPPGGIT TTDFIISLLD DRFIYYFFVV WHHQYYNNIK NNNPPVTIII SSSSKPLKVV RWWWPPGGIT TTDFIISLLD DRYLYYLLVV WHHQYYNNIA KKKPPVAVVV FFFFPSKKVV SWWWPPAAIT TTDIIISMMD DRFLYYVVSS WHHQYYDDIL KKKVVKNVVV TTTTPSKKVV EWWWPPAAIT TTDIIISMMD DRFLYYVVSS WHHQYYDDIK NNNPPKNVVV ---------- ---------- ---------- ---------- ---------- ---------- -------QGG EGGGEGGGMT TTDIIISLLD DRYLYYFFSS WHHQYYDDIA NNNPPRTVVV PPPPKLVDTT GGGGEGGGIS SSDIIISLLD DRFLYYVVNN WHHQYYDDIE NNNPPKTLLL ---------- ---------- ---------- ---------- ---------- ---------- EEEEQAKAVV AIIIPIPPPV VVDIIIAAAD DQTLWWIINN FDDLFFDDIH KKKPPFIKKK EEEEQAKAVV AIIIPVPPPV VVDIIISNND DSRLWWVVNN FDDLFFDDIH HHHPPRVKKK LGGGFRDPP- ---------- ----GGTAAQ EIISSDGRVV VNNNSSSYSS TWWDDQQFFY IGGGYRPPP- ---------- ----GGTAAQ SVVSSDGRVI INNNSSSYSS SWWNNQQFFY IGGGARPPP- ---------- ----GGAGGQ EIISSDGRVW WNNNSSSYSS TWWDDQQFFY IGGGARPPP- ---------- ----GGAGGQ EIISSDGRVW WNNNSSSYSS TWWDDQQFFY IGGGVKPPP- ---------- ----GGGGGQ EIISSDGKVW WNNNSSSYSS TWWDDQQFFY IGGGVRTPP- ---------- ---ANNNGGQ EIISSDGRVF FNNNSSSYGG AVVDDQQFFY IGGGVRGPP- ---------- ---ASSNGGQ EIISSDGRVF FNNNSSSYRR AWWDDQQFFY LGGGVKAPP- ---------- ----SSNGGQ EVVSSDGRVF FNNNSSSYAA SWWDDQQFFY LGGGIRGVVL EE-DELLQQQ ELVVGGPGGQ QLLSSDGKLA ATTTSSSYSS DWWDDQQFFY LGGGIKGVVL EE-DELLQQQ ELVVGGPGGQ QLLSSDGKLV VTTTSSSYSS AWWDDQQFFY LGGGIKGVVL EE-DELLQQQ ELVVGGPGGQ QLLSSDGKLV VTTTSSSYSS AWWDDQQFFY LGGGIKGVVL DD-DELLQQQ ELVVGGAGGQ QLLSSDGKLV VTTTSSSYSS AWWDDQQFFY LGGGIKGVVL EE-DELLQQQ ELVVGGAGGQ QLLSSDGKLI ITTTSSSYSS AWWDDQQFFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGGGIKGVVL EE-DELLQQQ ELVVGGAGGQ QLLSSDGKLI ITTTSSSYSS AWWDDQQFFY LGGGIKGVVL EE-DELLQQQ ELVVGGPGGQ QLLSSDGKIV VTTTSSSYSS DWWDDQQFFY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LGGGIRGVVL EE-DDLLQQQ DVIVGGPGGQ QLLSSDGKLV VNNNSSSYSS KWWDDQQFFY LGGGIRGVVL EE-DELLQQQ DVTVGGPGGQ QLLSSDGKIV VSSSSSSYSS IWWDDQQFFY VGGGIKSVVI GG-EGKKQQQ DPEIGGRGGQ QLLTTDGKLV VNNNSSSFSS AWWDDQQFFY AGGGIKSVVV KK-DGEEQQQ DPEIGGRGGQ QLLSSDGKLV VNNNSSSFSS AWWDDQQFFY VGGGLKSVVV GG-EGNNQQQ DPQIGGRGGQ QLLSSDGKLA ANNNSSSFSS AWWDDQQFFY VGGGLKSVVV GG-EGNNQQQ EPQIGGRGGQ QLLSSDGKLA ANNNSSSFSS AWWVVSSFFY AGGGLKSVVV TT-EDKKQQQ SPQVGGRGGQ QLLSSDGKIV VNNNSSSFSS RWWDDQQFFY IGGGVTSVVL EE-GK--PPP ELYVGGEGGQ QLLSSDGKLV VTTTSSSYKK KWWDDQQFFY IGGGISTVVL EE-EHDDEEE PLYVGGEGGQ QLLSSDGKLV VTTTSSSYKK KWWDDQQFFY ---------- ---------- -------GGA QLLSSDGKLV VNNNSSSYSS TWWDDQQFFY LGGGIRARRL NN-DELLAAA EVFLGGLGGQ QLLSSDGRLV VSSSSSSFSS PWWDDQQFFY LGGGISLNNV KKEDELLRRR PRYVGGEGGQ QLLSSDGKLV VSSSSSSYSS PWWDDQQFFY ---------- ---------- ---------- ---------- ---------- ---------- IDRRV----- ---------- ---------- SQQSSDGKVF FSSSSSSLAA NWWDD----- IGAAV----- ---------- ---------- SSSSSDGQLY YSSSSSSLAA NWWDD----- PEGKKGVVKN A-----GGEE IIDDKKFVVD GE-----ASS HRRSAAAASS YCYP------ P-GRRGAAKN V-----GGEE LLEEKKFVVD GR-----AAA HRRWAAAASS FCYP------ PDGPPAVVLH A-----GGTT LLAADDYVVE PDG----YAA HRRECCCCSS FCYPSSVVKR PDGPPGVVMN V-----GGEE LLDDKKYVVS PDG----YAA HRRECCCCSS FCYPSSVV-- PGDGGAVVMN V-----GGTT LLDDKKFVVD PAG----YSS HRRECCCCSS FCYPSSVV-- PEGDDGVVKD A-----GGEE FFDDPPFLLE PKG----HPP HRRQCCCCSS YCYP------ PDGKKGVVKD V-----GGQQ FFDDPPFVVD GE-----QVV HRRQAAAASS YCFP------ PVGRRGAAKE A-----GGSS LLDDPPFTTE GDG----LPP HRRESSSSSS YCYPSS---- -PDIIRSSVL QDDTTTGGKK LLNNPPFVVD GKEPGGPAAA HRRPCCCCSI WI-------- -PNIIRSSVL QDDTTTGGKK LLNNPPFVVD GKEPGGPAAA HRRPCCCCSI WI-------- -PDIIRSSVL QDDTTTGGKK LLNNPPFVVD GKEPGGPAAA HRRPCCCCSI WL-------- -PDIIRSSVL QDDTTTGGTT LLNNPPFVVD GKEPGGPAAA HRRPCCCCSI WL-------- -PDIIRSSVL QDDTTTGGKK LLNNPPFVVD GKEPGGPAAA HRRPCCCCSI WI-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -PDIIRSSVL QDDTTTGGKK LLNNPPFVVD GKEPGGPAAA HRRPCCCCSI WI-------- -PDIIRSSVL QDDTTTGGKK LLNNPPFVVD GKEPGGPAAA HRRPCCCCTI WL-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -PDIIKSSVL QDDTTTGGKK LLNNPPFVVD GKEPGGPVAA HRRPCCCCSI WV-------- -PDLLKAAVL QDDTTTGGKK LLNNPPFVVD GKEPGGPVAA HRRPCCCCTI WI-------- -PGVVESSHL QDDTTTGGKK IINNPPFVVD GAEPGGPAAA HRRPCCCCTI WI-------- -PKVVESSHL QDDTTTGGKK IINNPPFVVD GAEPGGPSAA HRRPCCCCTI WI-------- -PEMMDSSHI QDDTTTGGSS IINNPPFVVD GDEPGGPAAA HRRPCCCCTI WI-------- -PEMMESSHI QDDTTTGGTT IINNPPFVVD GDEPGGPSAA HRRPCCCCTI WI-------- GQDVVKSSHL QDDTTTGGSS IINNPPFVVD GAEPGGPSAA HRRPCCCCTI WI-------- -PEVVKAATV QNNPPPGGEE IINNRRFIID GKIEGGPYAA HRRPCCCCTI WI-------- -PEVVRAATL QDDPPPGGVV IINNKKFIID GKVPGGPYAA HRRPCCCCTI WI-------- -PNVVKSSVL QDDTTTGGTT VVNNKKFVVD GKEPGGPCAA HRRPSSSSTI LA-------- -PEVVAGGTV QDDVVVGGKK LLNNEEFVVD GGEPGGPGPP HRR------- ---------- -PKVVSGGHV LDDTTTGGSS LLNNEEFVVD ANEPGGPSPP HRRPCCCCTI WLANDDAA-- ---------- ---------- ---------- ---------- ---------- ---------- -----KKKDA QLLYYYDDEE LLVVEEFVVD YELGGG--AA HRRGLLLLY- ---------- -----KKKDE QLLYYYDDEE LLKKEEFIID YAEKGG--PP HRRGLLLLYP AGDGNNRRLV ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QAAAREE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NSSAKKKAKK PSSSSEATTT PRTAVPPTGG GGGLLTAARR RRAAAGGMSL AQLLLLSSLL gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLTPPPPPKK YAAWFSSSSS QQLSPSEGGG TPGGLISSSA AVVVKQQVSA AVQQWWAAWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------GG ---------- ---------- ---------- ---------- ---------- ----LLLLNN ---------- ---------- ---------- ---------- ---------- ---------- ---------- MRSATLPPPP NNRTPPNAAA SPRRVTRLLV VRRRYRRTVP RLPPCCPPHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIPFKRRDPP FSPKKPPELA YYVVACCLTT ---------- ---------- ---------- MMKLKPPDPP FTPRRPPEIA YYVVAAALVV ---------- ---------- ---------- --SMRPPDPP FSPQQPPEFA YYTTLLLLPP ---------- ---------- ---------- --TMRPPDPP FSPEEPPEFA YYTTLLLLPP ---------- ---------- ---------- --TLRPPDPP FSAEEPPELA FFTTLMMLPP ---------- ---------- ---------- MMTWKPPDPP FSPKKPPEIA YYVVAMMFPP ---------- ---------- ---------- MMTWRPPDPP FSPKKPPELA YYVVVRRLPP ---------- ---------- ---------- MMSWRPPDPP FSPQQPPELG YYVVALLLPP ---------- ---------- -------MMA CCK--CCGPP YPL--PPEIV YYLLPCCIRR ---------- ---------- ---------- ---------- -----PPEIV YYLLPCCIRR LLLLPPGHHG AAAALLAAGL LP----AHHS CCK--CCGPP YPL--PPEIV YYLLPCCIGG ---------- ---------- ---------- ---------- -----PPEII YYLLPCCIRR ---------- ---------- -------MMA CCN--CCGPP YPL--PPEIV YYLLPCCIRR ----AEREEG AAAFLLSAPM RPAAAASTTA CCN--CCGPP YPL--PPEIV YYLLPCCIRR ---------- ---------- -------MMA CCN--CCGPP YPL------- ---------- ---------- ---------- -------MMA CCN--CCGPP YPL--PPEIV YYLLPCCIRR LLLLGKEPPG HHHTQQWLGQ LWEEEEDTTA CCD--CCGPP YPQ--PPEIV YYLLPCCIRR SSSSQGCGGF DDDQNNEHYC TLFFFFTSSP CCN--CCGPP YPL--PPEIV YYLLPCCIRR ---------- ---------- -------MMA CCN--CCGPP YPL--PPEIV YYLLPCCIRR AAAARHSVVL QQQHMMGAVE TAAAAAANNG CCHTAKKGPP YPLKKPPELV YYVVTCCVNN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M CCS--CCGPP YPL--PPEIV YYLLPCCIRR ---------- ----MMTLHG VVEEEEKKKS NNCCKSSGPP YPI--PPELI YYVVTAAVAA ---------- ----MMTLHA VVEEEEKVVN QQCCKSSGPP YPL--PPELI YYVVTAAVAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRLQVGGGPP YPL--PPELI YYVVTAAVTT ---------- ---------- MAAAAAANNG CCGGATTGPP YPLKKPPELL YYVVTCCVNN ---------- ---------- -MPPPPNCCG CCG----GPP YPA--PPEVL FFVVTAAP-- ---------- ---------- -M-----CCP CCG----GPP YPA--PPEVL FFVVTAAP-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EEKCKCCGPP YPLNNPPELL YYVVVCCVPP ---------- ---------- ---------- ---------- ---SSPPELL YYTTVTTVPP ---------- ---------- ---------- -------MPP L--SSDDRLY FFSSNWWLGG MMMMKRRFFG --------AL AA----ALLA LLFRAFFADD TSPIIGGEFV YYVVWTTLVV MMMMKRFVVS GGGPMMFLAL VSLLLLALLA AAAGVRRADD TSPIIGGEYV YYVVWTTLAA TTRAIAVNNN PEEEEETTTY SKVVHKKKKK EPNDDEEELH HHGGGNNASS S-PGIRLIVV TTAPLAVDDD PPPPPPTTTY GKIIYKKKKK DPGDDEEELH HHGGGNNASS S-PALRLIVV FFRPLAVKKK PSSSSSTTTY GKVVHTTTTT TPGDDEEEFH HHGGGNNASS S-PTLRLIII FFKPLAVKKK PPPPPPTTTY GQVVHTTTTT TPGDDEEEFH HHGGGNNASS S-PAIRLIII AAKPLAVDDD PEEEEEKKKF GQVVHQQQQQ IPGDDEEEFH HHGGGNNASS S-PTLRLIII RRQPIAVDDD PPPPPPRRRY ASVVGQQQQQ APGDDEEELH HHGGGNNASS S-PAMRLVVV AAKPMCVDDD SSSSSSTTTF GQVVGVVVVV DPGGGEEELH HHGGGNNASS S-PAVRLVVV RRRPLGVDDD PGGGGGTTTY AQVVGRRRRR EPADDEEELH HHGGGNNASA A-PAVRLIVV TTAPLATDDD PPPPPPQQQY SQIIHRRRRR PPKDDEEELH HHGGGNNTSS S--FKRLILL TTAPLATDDD PPPPPPHHHY SQIIHRRRRR PPKDDEEELH HHGGGNNTSS S--FKRLILL TTAPLATDDD PPPPPPQQQY CQIIHRRRRR PPRDDEEELH HHGGGNNASS S--FKRLMLL TTAPLATDDD PPPPPPQQQY CQIIHRRRRR PPKDDEEELH HHGGGNNTSS S--YKRLVLL TTAPLATDDD PPPPPPQQQY CQIIHRRRRR PPKDDEEELH HHGGGNNTSS S--FKRLVLL TTAPLATDDD PPPPPPQQQY CQIIE----- ---------- ---------- ---------- --APLATDDD PPPPPPQQQY CQIIHRRRRR PPKDDEEELH HHGGGNNTSS S--FKRLVLL TTAPLATDDD PPPPPPQQQY CQIIHRRRRR PPKDDEEELH HHGGGNNTSS S--FKRLVLL TTAPLATDDD PPPPPPQQQY SQIIHRRRRR PPKDDEEELH HHGGGNNTSS S--FKRLVLL TTAPLATDDD PPPPPPQQQY CQIIHRRRRR PPKDDEEELH HHGGGNNTSS S--FKRLVLL TTAPLATDDD PPPPPPQQQY CQIIHRRRRR PPKDDEEELH HHGGGNNTSS S--FKRLVLL TTKLLATDDD PPPPPPTTTY SQIIHRRRRR PIGDDKKKLH HHGGGNNSSS S--HARLILL ---------- ---------- ---------- -PNDDEEELH HHGGGNNTSS S--YKRLILL TTKPLATDDD PPPPPPSSSY SQIIHRRRRR PPNDDEEELH HHGGGNNTSS S--YKRLILL TTKPLATDDD PPPPPPTTTY SKIIHRRRRR PPGDDEEELH HHGGGNNSSS S--HARLIAA TTKPLATDDD PPPPPPTTTY SKIIHRRRRR PPGDDEEELH HHGGGNNSSS S--HARLIVV ---------- ---------- ---------- -PGDDEEELH HHGGGNNSSS S--HARLVLL TTKPLATDDD PPPPPPSSSY SSIIHRRRRR PPGDDEEELH HHGGGNNSSS S--HVRLVLL TTKPLGTDDD PPPPPPTTTY SQIIHRRRRR PTGDDEEELH HHGGGNNASS S--HARLILL NNGPIFTNNN PDDDDDTTTF CQIISRRRRR DPGDDEEEVH HHGGGNNASS S--HERLIVV HHGPIFTNNN PEEEEETTTF CQIISRRRRR DPGDDEEEVH HHGGGNNASS S--HERLIVV ---------- ---------- ---------- ---------- ---------- ------MVPP LLHGLATDDD PPPPPPTTTY CQIIHRRRRR YNHNNEEELH HHGGGNNTSS SVPGPRLVLL LLHGLSTDDD PPPPPPTTTY CQVVHRRRRR FNGDDEEELH HHGGGNNASS SVDSPRLVLL IIDIRKNVVV GFFFFFLLLG GSLLKDDDDD PKEDDKKKEL LDQQQTTPIL L---QGMLQQ GGEQLVTRRR PAAAAATTTR GQIINSSSSS SGRNNEEEAH HHGGGSSA-- -----RFWTT GGEQLVTNNN PPPPPPQQQY GKVVNTTTTT SGRNNEEEAH HHDDDTTD-- -----RLWAA VPGRSRRRII DTTPRRRKII IIKIIIEKKV SSSGYYSSLV HCPAAYILLG GNNE-EG-GG VPARSRRRII DTTPRRRAVV VAKVVVVVGR TTTGYYTTYV HCPAAYILLG GGGP-DGRGG IPGRSRRRVV DTTPTTTRII IHKIIIELAK TTTGYYSSPV HCPGGYVLLG GGGAKDGTGP IPGRSRRRII DTTPTTTKII IHKIIIEFKK TTTGYYSSPI HCPGGYVLLG GGGGKDGTGP IPGRSRRRII DVV-LLLKII IHKIIIEFAK TTTGYYSSPI HCPGGYVLLG GGGGEDGTGP VPGRSRRRII DTTPLLLFLL LAKIIITAER TTTGYYSSPV HCPGGYVLLG GNNA-EG-GG VPDRSHHHII DTTPTTTKVV VVKIIIEAER TTTGYYAAPV HCPGGYILLG GSSP-EG-GG VPGRSRRRII DTTPRRRRII IVKIIIEHRR TTTGYYSSPI HCPGGYVLLG GSSP-EG-GG LPGMSRRRVV DVVSRRRKLL LHKIIIEQAK CCCNVVSSTS HCAGGVMTTL LGGD-LQGGG LPSISRRRVV DVVSRRRKLL LHKIIIEHAK CCCNLLGGLS HCAGGVMSSL LGGD-PQGGG LPCMSRRRVV DVVSRRRKLL LHKIIIDHAK CCCGLLGGVS HCAGGVMTTL LGGD-SKGGG LPAISRRRVV DVVTRRRKLL LHKIIIDHTK CCCNLLGGFS HCPGGVMTTL LGGD-PEGGG LPSISRRRVV DVVSRRRKLL LHKIIIDHAK CCCELLAALS HCAGGVMSSL LGGD-VKGGG ---------- ---------- ------DHAK CCCELLAALS HCAGGVMSSL LGGD-VKGGG LPSISRRRVV DVVSRRRKLL LHKIIIDHAK CCCELLAALS HCAGGVMSSL LGGD-VKGGG LPSISRRRVV DVVSRRRKLL LHKIIIDHAK CCCELLAALS HCAGGVMSSL LGGD-VKGGG LPSISRRRVV DVVTRRRKLL LHKIIIDHEK CCCGLLGGPS HCPGGVMTTL LGGD-PKGGG LPS------- ---------- ---------- ---------- ---------- ---------- LPSISRRRVV DVVSRRRKLL LHKIIIDHAK CCCELLAALS HCAGGVMSSL LGGD-VKGGD LPSLGRRRVV DTTTRRRSLL LHKVVVDAEN IIIGLLGGPS HCAGGIMCCL LGGD-KEGAG LPCISRRRVV DVVTRRRRII IHKVVVEFWK CCCGLLAALS HCGGGIMSSI IGGD-PYGGG LPCISRRRVV DVVSRRRRII IHKVVVEFWK CCCGLLAAPS HCGGGIMSSL LGGD-PCGGG APSVGRRRVV DTTTRRRSLL LHKVVVDIQK TTTGLLAAPS HCAGGLMCCL LGGD-KDGAG VPGVGRRRVV DTTTRRRSLL LHKVVVDSTK TTTGLLAAPS HCAGGIMCCI IGGD-KDGAG LPSIGRRRAA DTTERRRSLL LYKVVVEAEK TTTGLLAAPA HCAGGILCCL LGGD-EEGAG LPSIGRRRAA DTTERRRSLL LYKVVVEADK TTTGLLAAPA HCTGGILCCL LGGD-EEGAG LPSLGRRRVV DTTKRRRALL LHKVVVDAEK TTTGLLGGPS HCAGGIMCCL LGGD-KEGAG VPCNDRRRII NVVNRRRYLL LEHIIIKHSL NNN-LLSSPS HCAGGIMTTL LGGE-ANGPG VPCNDRRRVV NVVNRRRYLL LQHIIIKHAL NNN-LLSSPS HCAGGIMTTL LGGE-ADGPG PRKSGVVVKK FVVG------ ---------- ---------- ---------- ---------- LPCNDRRRVV DTTTRRRKLL LAKIIIDLKG AAADCCTTPT HCPGGIMIIM MGGD-AEGAG LPSNDFFFII DVVTRRREII IVKIIIDLKS HHHNVVTTPT HCAGGIMVVM MGGD-AEGAG QLSDKRRRVV TSSYWWWQFF FYP---DIKF LLLVLLAASA DYPTTLKGGV VNNE-SLSPL TGGDNRRRII DVVSSSSKLL LHKIIIFKDS GGGGVVVVPF FAPSSMILLS SNND-DDHGT AGGDSKKKVV DVVSAAAVLL LSKIIIFEKS GGGGVVVVPL YAPRRLILLS SNNN-KDHGT GGIILLLMLD DDHHEPLLLL GWIIDDQQQ- ---------- ------LLLA YYDDFNL-NN GGIIFFFLLD DDHHEPIIII GWVVYPQQQ- ---------- ------FFFA YYDDFNL-SS PPIIFFFIMD DDCCDVLLLL GWIIDPQQQ- ---------- ------KKKH YYDDFNL-RR PPVVFFFIMD DDCCEVLLLL GWIIDPQQQ- ---------- ------LLLH YYDDFNL-RR PPIIFFFILD DDCCEILLLL GYMMDEQQQ- ---------- ------KKKH YYDDFNL-RR GGIIAAAMLD DDAAEPLLLL GWVVEPQQQ- ---------- ------FFFA YYDDGHL-YY GGIIFFFILD DDHHEVLLLL GWIIDDQQQ- ---------- ------LLLH YYDDFHL-YY GGVVFFFVMD DDHHDPLLLL GWVVEPQQQ- ---------- ------LLLA YYDDFHL-YY GGFFVVVLLD DDGGEVKKKK GWKKPASSS- ---------- ------MMMG YYDDFQP-HH GGFFVVVLLD DDGGEVKKKK GWKKPEAAA- ---------- ------MMMG YYDDFQP-HH GGFFVVVLLD DDGGEVKKKK GWQQPAAAA- ---------- ------MMMG YYDDFQP-HH GGFFVVVLLD DDGGEVKKKK GWQQPAAAA- ---------- ------LLLG YYDDFQP-HH GGFFVVVLLD DDGGEVKKKK GWRRPAAAA- ---------- ------SSSG YYDDFQP-HH GGFFVVVLLD DDGGEVKKKK GWRRPAAAA- ---------- ------LLLG YYDDFQP-HH GGFFVVVLLD DDGGEVKKKK GWRRPAAAA- ---------- ------LLLG YYDDFQP-HH GGFFVVVLLD DDGGEVKKKK GWRRPAAAA- ---------- ------LLLG YYDDFQP-HH GGFFVVVLLD DDGGEVKKKK GWRRPSAAA- ---------- ------MMMG YYDDFQP-HH ---------- ---------- ---------- ---------- ---------- ---------- DDSSLLLVLL LLPPECSSSS G--------- ---------- ---------- ---------- GGGGFFFLLL LLDDNVKKKK GGNNRPIII- ---------- ------KKKE RRTTHENYWW GGFFVVVLLD DDGGEVKKKK GWAAEAAAA- ---------- ------FFFG YYDDFQP-HH GGFFVVVLLD DDGGEVKKKK GWVVESAAA- ---------- ------FFFG YYDDFQP-HH GGGGFFFLLL LLDDNVKKKK GWKKPSPPP- ---------- ------FFFG YYDDFQP-HH GGGGFFFLLL LLDDNVKKKK GWKKPSPPP- ---------- ------FFFG YYDDFQP-HH GGGGFFFLLL LLDDNIKKKK NWKKPSPPP- ---------- ------FFFG YYDDFQP-HH GGGGLLLLLL LLDDNIKKKK NWKKPSPPP- ---------- ------YYYG YYHHFQP-HH GGGGFFFLLL LLDDNVKKKK GWKKPSPPP- ---------- ------FFFG YYDDYQP-HH GGFFLLLLLD DDGGEPKKKK GWAADTVVV- ---------- ------FFFN YYDDFQP-RR GGFFLLLLLD DDGGEPKKKK GWAADVVVV- ---------- ------FFFN YYDDFQP-RR ---------- ---------- ---------- ---------- ---------- ---------- GGDDFFFVEF FFDDELVVVV GWRRGKAAA- ---------- ------CCCG YYDDYQP-FF GGDDFFFILF FFDDNCIIII GWKKGKAAA- ---------- ------CCCG YYDDFQP-FF LLGGIIIQTS SSKKGLSSSS AGAASEEEE- ---------- ------LLLQ LLSSNNG-RR TTLLVVVEYN NNDDYVAAAA TWPPTDMMMG GVVAAGGDAA AADDDDYYYG YYDDILI-KK TTLLVVVEYT TTNNYVAAAA TWPPTDLLLG GIIKKGG-KA AADDDDYYYD YYDDVLP-KK EVVVSEWWAV VVVN---IID DDDDLKLEHH HLKDDD-RHH WRRRIIHHLT LLLLGEEEEE GVVITEWWTV VVVR---FFE EEEEFSLECC CLKEEEGKHH WRHHLLYYID LLLLGQQEEE DYYVSEWWAL LLLP---FFN NNNNIVPEDD DLLAAANRHH WRNNVVQQID LLLLGAAQQQ DYYVTEWWAL LLLP---FFN NNNNIVPEDD DLLSSSNRHH WRNNVVQQID LLLLGAANNN DYYVSEWWGL LLLP---FFN NNNNIVPEDD DLLSSSNKHH WRNNVVQQID LLLLGAANNN DTTVTEWWGT TTTD---VVD DDDDLVPDII ILLGGGARHH WRHHLLQQID FFFFGDDEEE DTTLTEWWGT TTTR---VVS SSSSVLGDEE ELLAAAGRHH WRHHLLQQLD LLLLGAAEEE DTTVTEWWGT TTTN---IIG GGGGLDPQII ILLNNNKRHH WRHHLLQQLD VVVVGEEEEE NVVVSEWWAA AAAN---FFD DDDDNPAHVV VEA---GRFF WHIIIIQQLQ MMMMT----- NIIVSEWWAA AAAN---FFD DDDDNPAHVV VEA---GHHH WHIIIIQQLQ MMMMK----- NVVISEWWAA AAAN---FFD DDDDNPADVV VEA---GHHH WHIIIIQQLT LLLLQ----- NVVISEWWAA AAAN---LLD DDDDNPADVV VKA---GHYY WRIIVVQQLP LLLLQ----- NVVISEWWAA AAAN---LLD DDDDNPADVV VEA---GHYY WHIIVVQQLS LLLLK----- NVVISEWWAA AAAN---LLD DDDDNPADVV VEA---GHYY WHIIVVQQLS LLLLK----- NVVISEWWAA AAAN---LLD DDDDNPADVV VEA---GHYY WHIIVVQQLS LLLLK----- NVVISEWWAA AAAN---LLD DDDDNPADVV VEA---GHYY WHIIVVQQLS LLLLK----- NVVISEWWAA AAAN---VVN NNNNNPADVV VEA---GHHH WHIIVVQQLL MMMMP----- ---------- ---------- ---------- ---------- ---------- ---------- -----ISSAH HHHN---RRT TTTTRDYPAA ASA---SI-- ---------- ---------- GLLWSIQQCC CCCL---YYT TTTTELMCLL LTA---SICC DRIIDDEELP LLLLQ----- NVVISEWWGA AAAK---FFL LLLLKMEEVV VQA---GSNN WHRRIIQQID LLLLGEE--- NVVISEWWGA AAAK---FFL LLLLKMEDVV VQA---GSNN WHLLVVQQID LLLLGKK--- NTTISSWWGA AAAT---FFK KKKKDLQHVV VAD---GHTT IGLLRRQQLD LLLLGNN--- NTTISSWWGA AAAK---FFQ QQQQNLQHVV VAD---GHHH YGIIKKQQLD LLLLGDD--- KTTISSWWGA AAAK---FFK KKKKDLQHVV VAD---GHHH YGMMKKQQID LLLLGEE--- KTTISSWWGA AAAK---FFK KKKKNLQHVV VAD---GHHH YGIIKKQQID LLLLGPP--- KTTISSWWGA AAAA---FFT TTTTDLQHVV VQD---GHHH YGLLKKQQLD LLLLGSS--- NVVISEWWGS SSSN---IIK KKKKNPAHVV VGE---GSHH FKYYLLQQID LLLLPQQPPP NIIISEWWGS SSSN---IIK KKKKNPAHVV VPE---GSHH FKHHLLQQID LLLLPMMPPP ----SLRRGG GGGV---VVR RRRRELKCQQ QPE---PCRR Y--------- ---------- NVVVAEWWGA AAAK---FFR RRRRHPTDCC CDDRRRTRNN YRLLFFQQID LLLLGDD--- DVVVSEWWGA AAAN---WWR RRRRKNVDLL LEDMMMSRNN YQLLYYQQID LLLLGSS--- EKKESRPPDE EEEI---AAE EEEEESFLKK KKTGGGPHAA V--------- ---------- NVVLTSFFTG GGGSNNYMMF FFFFMLQDAA AEAMMMKTVV WRPPKKKKFN VVVVPGGAAA NLLVTSFFTG GGGNNNYMMF FFFFMLADPP PEAMMMKTVV WKPPKKKKFD VVVVPGGAAA NNNRMMMMMA LLLLL----L LHHDDDLMMG FIMMVKLSSI LLFYYY-DGK KKAKIIEEAA HHHRMMMMMV LLLLL----L LHHDDDLMMG FVVVVKLSSI LLFYYY-DGK KKARIIDDAA HHHQMMMMMA LLLLL----A AHHDDDEYYG FVVVVTLGSI TTWRRR-GGK KKVKAATTAA HHHQMMMMMA LLLLL----A AHHDDDEYYG FVVVVTLASI TTWRRR-GGK KKAKAATTPP HHHQMMMMMA LLLLL----A AHHDDDDYYG FCVVVTLGAI TTWQQQKDGT TTAKIITTPP HHHQLLLLLV FFFFF----A AHHDDDAYYG FVCCVKLSSI TTYRRR-KDK KKVKIIEEAA YYYQMMMMMA LLLLL----A AHHDDDAYYG FMCCVKLASI LLYRRR-NGS SSLKIIDDAA HHHQMMMMMV LLLLL----A AHHDDDTYYG FVVVVELASV LLHRRR-NGS SSIKIIEEAA DDDGLLLLLI PPPPP---LL LHHDDDTQQG FVCCANQFYK EEG------- ----TTWWEE DDDGLLLLLI PPPPP---LL LHHDDDTQQG FVCCANQFYK EEG------- ----TTWWEE DDDGLLLLLI PPPPP---LL LHHNNNAQQG FVCCATQFYK QQG------- ----TTWWEE DDDGLLLLLI PPPPP---LL LHHNNNAQQG FVCCATQFFK EEG------- ----TTWWQQ DDDGLLLLLI PPPPP---LL LHHNNNAQQG FVCCATQFYK EEG------- ----TTWWEE DDDGLLLLLI PPPPP---LL LHHNNNAQQG FVCCATQFYK EEG------- ----TTWWEE DDDGLLLLLI PPPPP---LL LHHNNNAQQG FVCCATQFYK EEG------- ----TTWWEE DDDGLLLLLI PPPPP---LL LHHNNNAQQG FVCCATQFYK EEG------- ----TTWWEE DDDGHHHHHI PPPPP---LL LHHDDDSQQG FVCCATQFYK EEG------- ----TTWWEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDDQAAAAAG AAAAANNNLI IHHWWWNQQD YDVVESRGSD DDY------- ----AAVVKK DDDGLLLLLI PPPPP---LL LHHDDDAQQG LVCCATFFYK KKG------- ----KKWWEE DDDGLLLLLI PPPPP---LL LHHNNNDQQG LVCCASFFYK KKG------- ----KKWWEE TTTGLLLLLL PPPPP---LL LHHDDDDTTG FVSSANIFFK QQG------- ----SSWWEE KKKGLLLLLL PPPPP---LL LHHDDDDTTG FVSSANIFFK QQG------- ----SSWWEE TTTGLLLLLL PPPPP---LL LHHDDDDTTG YVSSANIFFK SSD------- ----TTWWEE TTTGLLLLLL PPPPP---LL LHHDDDDTTG FVSSANIFFK SSE------- ----TTWWEE TTTGLLLLLL PPPPP---LL LHHDDDDTTG YVCCANVFFK AAG------- ----SSWWEE LLLGAAAAAL PPPPP---LL LHHEEEEHHA FVCCAGFIHP EENSSS---- ---TTTHHTT RRRGAAAAAL PPPPP---LL LHHEEEEHHA FVCCAAFIHP EENPPP---- ---KVVQQSS ---------- ---------- ---------- ---------- ---------- ---------- DDDGLLLLLT PPPPP---LL LHHNNNNQQG YVCCAXXXX- ---------- ---------- DDDGIIIIIT PPPPP---LL LHHNNNAEEG FVCCAKFFKK SSSDDD---- ---EEEAAVV ---------- ---------- ---------- ---------- ---------- ---------- PPP------- --------LP PWWGGGNYYA FSTTAQWIYE DDG------- ---------- PPP------- --------LA AWWGGGNYYC FTTTAQWIYE GGG------- ---------- PGGG-PEIPF FVPPPPPPLL TTIDISSLDD DLLLSLLLLG GGGGRDISNN PFKKVGGGGK PGGG-PPVDF FVPPPPPPLL TTIDISSLDD DLVVSLLLLG GGGGRDITNN PHQQRGGGGR PAAADPPLGF FVPPPPPPLL TTIDLSSLDD DLVVSCCCCG GGGGRDVSDD PHNNVGGGGS PKKKEPPLGF FVPPPPPPLL TTIDLSSMDD DLVVSCCCCG GGGGRDVSDD PRKKKGGGGS PAAADPDLGF FCPPPPPPLL TTIDLSSLDD DLVVACCCCG GGGGHDVSDD PMNNVGGGGK APPPDPPVGF FVPPPPPPLL TTIDLSSMDD DLVVSCCCCG GGGGLDVSDD PFEEKGGGGK PEEEDPPIPF FVPPPPPPLL TTINLSSVDD DLVVSCCCCG GGGGHDVSDD PFNNRGGGGK PPPPDPPLDF FVPPPPPPLL TTINLSSLDD DLVVSCCCCG GGGGRDVSDD PFNNRGGGGS VVVVPKVKML LMPPPPPGLL TTILLSSLDD DLFFSNNNNL LLLGRDISNN PQKKRGGGGQ VVVVPKVKML LMPPPPPGLL TTILLSSLDD DLFFSNNNNL LLLGRDISNN PKKKRGGGGQ VVVVPKVKML LMPPPPPGLL TTILLSSLDD DLFFSNNNNL LLLGRDISDD PQRRRGGGGQ VVVVPKVKML LMPPPPPGLL TTILLSSLDD DLFFSNNNNL LLLGRDVSDD PQRRRGGGGQ VVVVPKVKLL LMPPPPPGLL TTILLSSLDD DLFFSNNNNL LLLGRDISDD PQRRRGGGGQ VVVVPKVKLL LMPPPPPGLL TTILLSSLDD DLFFSNNNNL LLLGRDISDD PQRRR----- VVVVPKVKLL LMPPPPPGLL TT-------- ---------- ---------- ---------- VVVVPKVKLL LMPPPPPGLL TTILLSSLDD DLFFSNNNNL LLLGRDISDD PQRRRGGGGQ VVVVPKVKML LMPPPPPGLL TTILLSSLDD DLFFNNNNNL LLLGRDISDD PKRRRGGGGQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KLLLYVVAGV VLSSSSSNEE PPAWIFFFSS DIFFLSSSS- ---------- ---------- VVVVPKVEAL LMPPPPPGLL TTILISSLDD DLFFSNNNNL LLLGRDITDD PRNNKGGGGQ VVVVPKVEPM MMPPPPPGLL TTILISSLDD DLFFSNNNNL LLLGRDITDD TRNNKGGGGQ AVVVKKVQIL LMPPPPPGLL TTFLISSLDD DLFFVNNNNL LLLGRNIEDD LKNNVGGGGQ VVVVEKVQFL LMPPPPPGLL TTFLISSLDD DLFFVNNNNL LLLGRNIEDD VKNNKGGGGQ VVVVKKVEIL LMPPPPPGLL TTFLISSLDD DLFFVNNNNL LLLGRNIEDD PKNNVGGGGQ VVVVKKVEIL LMPPPPPGLL TTFLISSLDD DIFFVNNNNL LLLGRNIEDD PKNNVGGGGQ AIIIKKVRIL LMPPPPPGLL TTFVISSLDD DLLLVNNNNL LLLGRNIEDD PAKKVGGGGQ VIIIPKVSAL LMPPPPPALL TTILISSMDD DLVVSCCCCL LLLGRDISDD PLKKKSSSSQ VIIIPKVEAL LMPPPPPALL TTILISSMDD DLVVSCCCCL LLLGRDISDD PKNNKSSSSQ ---------- ---------- ---------- ---------- ---------- ---------- -----QGEEI IMGGGGGGMM TTILISSLDD DLFFSNNNNR RRRGRDISDD RANNRGGGGQ DGGGKDTGVA AMGGGGGGMM SSIIISSLDD DLVVNCCCCR RRRGRDITDD PENNKGGGGQ ---------- ---------- ---------- ---------- ---------- ---------- -WWWQAVAGN NDIIIIIPLL VVISIAAADD DLIINSSSSM MMMGRDISDD PHKKFYYYYE -WWWQAVAGE EKVVVVVPLL VVISISSNDD DLVVNTTTTM MMMGRDISDD PHHHRYYYYE KKLGFFFHRA P--------- --------GH KLLTQQQMLL ERRGRRVYYT SSLLWDQPGG RRIGYYYHRE P--------- --------GA EAATQQQMII SRRGRRVYYT SSLLWNQPGG SSIGAAARRA P--------- --------GR TFFAQQQMVV ERRGRRVYYT SSLLWDQPGG SSIGAAARRT P--------- --------GK AFFAQQQMVV ERRGRRVYYT SSLLWDQPGG KKIGVVVKKT P--------- --------GK TFFGQQQMVV ERRGKKVYYT SSLLWDQPDD KKIGVVVSRA PG-------- --------NG ALLNQQQMVV ERRGRRVYYT SSLLVDQPGG KKIGVVVRRA P--------- --------SA ELLNQQQMVV ERRGRRVYYT SSLLWDQPGG SSLGVVVRKA P--------- --------SG PLLNQQQMVV ERRGRRVYYS SSLLWDQPGG QQLGIIIVRG VQVEDDQEET TCQPPEPVGK RIIPQQQMII QLLGKKLYYT SSLLWDQ-DD QQLGIIIVKG VQVEDDQEET TCQPPEPVGK RVVPQQQMII QLLGKKLYYT SSLLWDQ-NN QQLGIIIVKG VQVEDDQEEK KSQPPEPVGK KVVPQQQMII QLLGKKLYYT SSLLWDQ-DD QQLGIIIVKD VQVDDDQEED DSQPPEPVGK QVVAQQQMII QLLGKKLYYT SSLLWDQ-DD QQLGIIIVKG VQVEDDQEEK KSQPPEPVGK RVVAQQQMII QLLGKKLYYT SSLLWDQ-DD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQLGIIIVKG VQVEDDEEEK KSQPPEPVGK RVVAQQQMII QLLGKKLYYT SSLLWDQ-DD QQLGIIIVKG VQVEDDQEEK KSQPPEPVGK RVVPQQQMII QLLGKKIYYT SSLLWDQ-DD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQLGIIILRG VTVEDDKDDE ECQPPDPIGK KVVPQQQMII QLLGKKLYYT SSLLWDQ-DD QQLGIIIQRG VTVEDDKEEE ECQPPDPTGK IIIPQQQMII QLLGKKIYYT SSLLWDQ-DD QQVGIIIQKG VAAGEEDGGT TWQSSDVEGQ KLLRQQQMII QLLGKKLYYT SSLLWDQ-GG QQAGIIIQKG VVAKDDDGGT TWQSSDVEGK KLLRQQQMII QLLGKKLYYT SSLLWDQ-KK QQVGLLLQKG VKAGEEDGGS SFQFFDVQGK SLLRQQQMII QLLGKKLYYT SSLLWDQ-EE QQVGLLLQKG VKAGEEDGGT TFQFFEVQGK SLLRQQQMII QLLGKKLYYT SSLLWVS-EE QQAGLLLQKG VVYTEEDDDE EEQYYSVQGH RLLRQQQMII QLLGKKIYYT SSLLWDQGDD QQIGVVVHTE VKVEGGEKK- --PIIEAYGR KIIEQQQMLL QLLGKKLYYT SSLLWDQ-EE QQIGIIIHSE VKVEEEDHH- --EIIPAYGR QIIEQQQMLL QLLGKKLYYS SSLLWDQ-EE ---------- ---------- ---------- ----AAAKII QVVGKKLYYT SSFFWDQ-NN QQLGIIIQRD RRVNDDPEEK KEAPPEPFGR RLLLQQQMLL QLLGRRLYYS SSLLWDQ-EE QQLGIIICSD NVIKDDKEEK KERPPPAYGR RLLEQQQMLL QLLGKKLYYS SSLLWDQ-KK ---------- ---------- ---------- ---------- ---------- ---------- EEIDVVVN-- ---------- ---------- -------MVV SWWGKKVYYS SSLLWD---- EEIGVVVN-- ---------- ---------- -------MVV SWWGQQLYYT SSLLWD---- LGWMMVKKLL NA--PPGGLE KEEEEDE--- -RHQVRLSSS GGGDASSSSD SSYPP----- LGWMMAKKVV NV--PPGGLE KEEEEDR--- -RHQVRLWWW GGGDASTTTD SSYPP----- VAAQQVLLAA HA--PPGGLT DDDDDED--- -RHQIRLEEE GGGDCSTTTD SSYPPSSVRR VGVEEVMMAA NV--GGGGLE KDDDDSD--- -RHQIRLEEE GGGDCSTTTD SSYPPSSV-- RAAMMVMMAA NV--EEGGLT KDDDDDA--- -RHQIRLEEE GGGDCSTTTD SSYPPSSV-- IGWMMVKKLL DA--PPGGIE PKKKKEK--- -RHQVRLQQQ GGGDCSSSSD SSYPP----- IGWMMVKKVV DV--PPGGMQ PNNNNDE--- -RHQIRLQQQ GGGDASSSSD SSFPP----- IGWIIAKKAA EA--PPGGLS PGGGGED--- -RHQIRLEEE GGGDSSSSSD SSYPPSS--- LREGGSVVMM LQDTVVGGLK PNNNNDKPLP PLHELRYPPP GGGDCSSSSD II-------- LREGGSVVMM LQDTAAGGLK PNNNNDKPLP PLHELRYPPP GGGDCSSSSD II-------- LREGGSVVMM LQDTVVGGLK PNNNNDKPLP PLHELRYPPP GGGDCSSSSD II-------- LREGGSVVMM LQDTVVGGLT PNNNNDKPLP PLHELRYPPP GGGDCSSSSD II-------- LREGGSVVMM LQDTVVGGLK PNNNNDKPLP PLHELRYPPP GGGDCSSSSD II-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LREGGSVVMM LQDTVVGGLK PNNNNDKPLP PLHELRYPPP GGGDCSSSSD II-------- LREGGSVVMM LQDTVVGGLK PNNNNDKPLP PLHEIRYPPP GGGDCTSSSD II-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MKEGGSVVMM LQDTEEGGLK PNNNNDKPGP PLHELRYPPP GGGDCSSSSD II-------- LKEGGAVVMM LQDTKKGGLK PNNNNDKPDP PLHEIRYPPP GGGDCTSSSD II-------- LEKGGSHHII LQDTEEGGLK PNNNNDAPDP PLHEMRYPPP GGGDCTSSSD II-------- LEQGGSHHII LQDTEEGGLK PNNNNDAPDP PLHEMRYPPP GGGDCTSSSD II-------- LDKGGSHHII IQDTEEGGLS PNNNNDDPEP PLHEMRYPPP GGGDCTSSSD II-------- IEKGGSHHII IQDTEEGGLT PDDDDDDPDP PLHEMRYPPP GGGDCTSSSD II-------- LKKGGSHHMM LQDTEEGGLS PNNNNDAPEP PLHEMRYPPP GGGDCTSSSD II-------- HKSGGATTMM VQDPEEGKME RDDDDDKEGP PLHEMRYPPP GGGDCTSSSD II-------- NRSGGATTMM LQDPIIGHMV KNNNNDKPGP PLHEMRYPPP GGGDCTSSSD II-------- VKEGGSVVMM LQDTEEGGLT KNNNNDKPNP PLHDIRFPPP GGGDSTSSSD II-------- MAAGGGTTII VQDVEEGGMK ENNNNDGPYP PLHEMR---- ---------- ---------- MSQGGGHHII VLDTVVGGIS EDDDDDNPYP PLHEMRYPPP GGGDCTSSSD IIANNDDA-- ---------- ---------- ---------- ---------- ---------- ---------- -KKGGKDDDD AQAYNNDGKE EDDDDDEGL- -RHIMRFGGG SSSALYSSSS ---------- -KKGGKDDDD EQLYYYDGKE EQQQQDAKL- -RHQMRFGGG RRRALYAAAG PPDGGNNRVV ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QQQQAVV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNSAAAAKKK QPSSEAACRA VPTGGGLLLL AAAALADDDD AMSLRTTAQQ LLLLLLTPRA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YAASAAAAQL LLAAASSRES SKKKTRRPGG LEIISSSSSA AAVVVKQQQV VVVVPSSQAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MRRLPPPPNR RRTTTPTHNP PLLASPPPRR VLTTRLLLLV VVRRRYRRRT TTIINVVPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMMII VVPPFFKRTY PPSPMMMPPE ---------- ---------- ---------- --------MM AAKKLLKPTY PPTPDDDPPE ---------- ---------- ---------- ---------- MMSSMMRPTH AASPLLLPPE ---------- ---------- ---------- ---------- MMTTMMRPTH AASPLLLPPE ---------- ---------- ---------- ---------- MMTTLLRPTY PPSALLLPPE ---------- ---------- ---------- --------MM AATTWWKPSY PPSPLLLPPE ---------- ---------- ---------- --------MM VVTTWWRPTY PPSPMMMPPE ---------- ---------- ---------- --------MM AASSWWRPTY PPSPMMMPPE ---------- ---------- ---------- MMAAATTTCC TTKK---CGP TTPLAAAPPE ---------- ---------- ---------- ---------- ---------- -------PPE AAQQWHLPPP PPPHGGGAAV VIAAAGGL-- HHSSSTTTCC GGKK---CGP SSPLAAAPPE ---------- ---------- ---------- ---------- ---------- -------PPE ---------- ---------- ---------- MMAAATTTCC GGNN---CGS TTPLAAAPPE -------AAA EEEEGGGAAT TQSAAPPRAA TTAAATTTCC GGNN---CGS TTPLAAAPPE ---------- ---------- ---------- MMAAATTTCC GGNN---CGS TTPLAAA--- ---------- ---------- ---------- MMAAATTTCC GGNN---CGS TTPLAAAPPE -----MLGGG KKKPGGGHHA APWLLGGLEE TTAAATTTCC GGDD---CGP TTPQAAAPPE ----LKSQQQ GGGGFFFDDT TTEHHYYTFF SSPPPTTTCC GGNN---CGS TTPLAAAPPE ---------- ---------- ---------- MMAAATTTCC GGNN---CGS TTPLAAAPPE PRPPCPARRR HHHVLLLQQI IEGAAVVTAA NNGGGKKKCC CCHHTTAKGA TTPLAAAPPE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMMAAACC GGSS---CGK SSPLAAAPPE ---------- ---------- -ATLLHHVEE KKSSS---NN GGCCCCKSGA SSPISSSPPE ---------- ---------- -GTLLHHVEE VVNNNNNNQQ GGCCCCKSGA SSPLAAAPPE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------RR MMLLQQVGGA TTPLAAAPPE ---------- ---------- -------MAA NNGGGAAACC CCGGGGATGA TTPLAAAPPE ---------- ---------- --------PP CCGGGLLLCC HHGG----GA SSPAAAAPPE ---------- ---------- ---------- CCPPPLLLCC HHGG----GA SSPAAAAPPE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MMMEE SSKKCCKCGA TTPLAAAPPE ---------- ---------- ---------- ---------- ---------- -------PPE ---------- ---------- ---------- ---------- --------GI TT--IIIDDR ------MKKK RRRFGGG--- -----AAA-- LLAAAMMMLL PPFFRRAFEC QQSPMMMGGE ------MKKK RRRVSSSGGS SHFLLAAVLL LLAAALLLAA PPAAGGVREC AASPMMMGGE EEEEDLAAYY YAAACYTGGT TIRAADFFIV VVVVVPKEYI HVVEELYIIN DDDELHHGGW EEEEDIAAYY YAAAAYVGGT TVAPPDFFLV VVVVVPKPYV YLLDDLYIIG DDDELHHGGW EEEEEFAAYY YLLLLSPDDF F-RPPDAALV IVVVVPGSYI HVVTTMNTTG DDDEFHHGGW EEEENFAAYY YLLLLSPDDF F-KPPDAALV IVVVVPGPYI HVVTTMNKKG DDDEFHHGGW EEEEKLAAFF FLLLMSPDDA A-KPPDGGLV VVVVVPTEFI HLLIIMNKKG DDDEFHHGGW EEEETIAAYY YAAAMDPEER R-QPPDAAIV VVVVVPAPYI GVVAAMHAAG DDDELHHGGW EEEEKLAAYY YVVVRNPMMA AGKPPDAAMV VVVVVSQSFV GTTDDMYTTG GGGELHHGGW EEEERLGGYY YAAALDPGGR R-RPPDAALV LLLLLPDGYI GVVEEMNAAA DDDELHHGGW EEEEEIVVYY YPPPCYRNNT TTAPPDYYLT VVVVVPKPYV HLLPPMYLLK DDDELHHGGW EEEEEIVVYY YPPPCYRNNT TIAPPDYYLT VVVVVPKPYV HLLPPMHLLK DDDELHHGGW EEEEEIVVYY YPPPCYGNNT TIAPPDYYLT VIIIIPKPYV HLLPPMNLLR DDDELHHGGW EEEEEIIIYY YPPPCYRNNT TIAPPDYYLT VVVVVPKPYV HLLPPMHLLK DDDELHHGGW EEEEEIVVYY YPPPCYRNNT TTAPPDYYLT VVVVVPKPYV HLLPPMNLLK DDDELHHGGW EEEEEIVVYY YPPPCYRNNT TTAPPDYYLT VVVVVPKPYV E--------- ---------- ---------- ---------- -TAPPDYYLT VVVVVPKPYV HLLPPMNLLK DDDELHHGGW EEEEEIVVYY YPPPCYRNNT TTAPPDYYLT VVVVVPKPYV HLLPPMNLLK DDDELHHGGW EEEEEIVVYY YPPPCYRNNT TTAPPDYYLT VVVVVPKPYV HLLPPMYLLK DDDELHHGGW EEEEEIVVYY YPPPCYRNNT TTAPPDYYLT VVVVVPKPYV HLLPPMNLLK DDDELHHGGW EEEEEIVVYY YPPPCYRNNT TTAPPDYYLT VVVVVPKPYV HLLPPMNLLK DDDELHHGGW EEEEKLVVYY YTTTCYNGGT TIKLLDYYLT VLLLLPSPYV HLLPPVHIIG DDDKLHHGGW ---------- ---------- ---------- ---------- -----MNTTN DDDELHHGGW EEEEEIVVYY YPPPCYRSST TIKPPDYYLT VVVVVPKPYV HLLPPMNVVN DDDELHHGGW EEEESLIIYY YTTTAYAGGT TIKPPDYYLT VVVVVPSPYV HLLPPVYVVG DDDELHHGGW EEEETLIIYY YTTTAYAGGT TIKPPDYYLT VLLLLPNPYV HLLPPVYVVG DDDELHHGGW ---------- ---------- ---------- ---------- -----MFVVG DDDELHHGGW EEEEKLIIYY YTTTAYTGGT TIKPPDYYLT VVVVVPSPYV HLLPPMFVVG DDDELHHGGW EEEEKLLLYY YTTTCYNGGT TIKPPDYYLT VVVVVPNPYV HLLPPVHVVG DDDELHHGGW EEEEEVLLFF FTTTA----N NAGPPDAAIT VVVVVPEDFV SVVDDVHIIG DDDEVHHGGW EEEEEVLLFF FTTTA----H HRGPPDAAIT VVVVVPEEFI SVVDDVNIIG DDDEVHHGGW ---------- ---------- ---------- ---------- ---------- ---------- EEEEKLLLYY YVVVCQPNNL LEHGGDYYLT VVVVVPAPYV HTTYYTSKKH NNNELHHGGW EEEEKLLLYY YVVVTQPNNL LEHGGDYYLT VVVVVPEPYI HTTFFTRKKG DDDELHHGGW RRRRFLYYFF FNNNWHGDDI IQDIITDDRN PMMMMGQFGV KGGPPVVLLE DDDKELDQQP EEEEEFVVYY YWWWTGVEEG GGEQQDKKLT ILLLLPGARV NVVSSVG--R NNNEAHHGGF EEEEDYVVYY YWWWTGAEEG GGEQQDKKLT VAAAAPKPYV NLLSSVG--R NNNEAHHDDF WWWSSNNN-K NIEERFIVSS RIIDTTKNNP PPRPKKKKKI IIIKVVIIEP PVKKVSSGGS WWWSSNNN-K FLEERYIVSS RIIDTTKDDK KKRPAAAAAV VVAKIIVVEP PAVGRTTGGT WWWSSLLLGH FLEERFIISS RIVDTTKHHP PPTARRRRRI IIHKIIIIEP PILAKTTGGS WWWSSLLLGH FIEERYIISS RIIDTTKDDP PPTAKKKKKI IIHKIIIIEP PVFKKTTGGS WWWSSLLLGH FLEERYIISS RIIDVVKEEP PPLAKKKKKI IIHKIIIIEP PVFAKTTGGS WWWSSNNNPH HMEERYVVSS RIIDTTKDDP PPLPFFFFFL LLAKVVIIEP PLAERTTGGS WWWSSNNNPH HVEERYVVSS HIIDTTKDDP PPTPKKKKKV VVVKVVIIDP PLAERTTGGA WWWSSYYYPH HVEERYIVSS RIIDTTKDDP PPRPRRRRRI IIVKVVIIEP PLHRRTTGGS WWWSS---GD TKSSNKILSS RIVDVVGEEP PPRPKKKKKL LLHKVVIIEA AIQAKCCNNS WWWSS---GD TKSSDKILSS RIVDVVGEEP PPRPKKKKKL LLHKVVIIEP PIHAKCCNNG WWWSS---GD TKSSTKMLSS RIVDVVGDDP PPRPKKKKKL LLHKVVIIEA AIHAKCCGGG WWWSS---GD TKAATKVLSS RIVDVVGEEP PPRPKKKKKL LLHKVVIIEP PIHTKCCNNG WWWSS---GD TKSSTKVLSS RIVDVVGEEP PPRPKKKKKL LLHKVVIIEP PIHAKCCEEA ---------- ---------- ---------- ---------- ---------P PIHAKCCEEA WWWSS---GD TKSSTKVLSS RIVDVVGEEP PPRPKKKKKL LLHKVVIIEP PIHAKCCEEA WWWSS---GD TKSSTKVLSS RIVDVVGEEP PPRPKKKKKL LLHKVVIIEP PIHAKCCEEA WWWSS---GD TKSSNKVLSS RIVDVVGEEP PPRPKKKKKL LLHKVVIIEA AIHEKCCGGG WWWSS---GD TKSSTKVL-- ---------- ---------- ---------- ---------- WWWSS---GD TKSSTKVLSS RIVDVVGEEP PPRPKKKKKL LLHKVVIIEP PIHAKCCEEA WWWSS---GD SAKKRFILGG RVVDTTADDP PPRPSSSSSL LLHKVVVVES SIAENIIGGG WWWSS---GD SKVVNKILSS RIVDVVGDDP PPRPRRRRRI IIHKTTVVEP PVFWKCCGGA WWWSS---GD SKVVNKILSS RIVDVVGDDP PPRPRRRRRI IIHKTTVVEP PVFWKCCGGA WWWSS---GD SAEERFIAGG RIVDTTKNNP PPRPSSSSSL LLHKVVVVDP PIIQKTTGGA WWWSS---GD SAQQRFIVGG RVVDTTKNNP PPRPSSSSSL LLHKVVVVEP PISTKTTGGA WWWSS---GD SADDRYVLGG RIADTTKNNP PPRPSSSSSL LLYKYYVVDP PIAEKTTGGA WWWSS---GD SVDDRYVLGG RIADTTKNNP PPRPSSSSSL LLYKYYVVDP PIADKTTGGA WWWSS---GD SASSRFILGG RVVDTTLDDP PPRPAAAAAL LLHKVVVVEA AIAEKTTGGG WWWSS---DK TEKKSHIVDD RIINVVEEE- --RIYYYYYL LLEHTTIIEP PLHSLNN--S WWWSS---DK TEKKSHIVDD RIVNVVEEE- --RIYYYYYL LLQHTTIIEP PLHALNN--S ---------- ------VPGG VEKFVVG--- ---------- ---------- ---------- WWWSS---GK VPTTDRVLDD RIVDTTGDDP PPRPKKKKKL LLAKVVIIEG GVLKGAADDT WWWSSEEESK VPKKDRVLDD FIIDVVVDDP PPRPEEEEEI IIVKTTIIDG GVLKSHHNNT PPPII---GK VQGGPQLQKK RLVTSSLSSA AAWKQQQQQF FFYP------ -LIKFLLVVA FFF------- --DDRFWTNN RIIDVVHDDP PPSPKKKKKL LLHKTTIIDT TVKDSGGGGV FFF------- --DDRYWASS KIVDVVHDDP PPAPVVVVVL LLSKTTIITD DVEKSGGGGV SSHHTGGPDA IYSAEE--EE EEPPGLMMLL SSFEELLLLG KWEEEERDQY YYY------- TTHHTGGPDA IYSAPP--DD EEPPGFLLLL TTFEEIIIIG RWEEEERPQY YYY------- SSHHTGGPEG IYSTAAGGDD DDAAPFIIMM TTFDDLLLLG RWEEEERPQD DDD------- SSHHTGGPDG IYSTGGGGDD NNPPPFIIMM TTFEELLLLG RWEEEERPQT TTT------- SSHHTGGPEG IYSTGGGGDD DDPPPFIILL TTFEELLLLG RYEEEEREQT TTT------- SSHHTGGPGG IYTAAA--EE KKPPGAMMLL SSFEELLLLG RWEEEERPQY YYY------- AAHHTGGPDG IYSAPP--EE EEPPGFIILL NNLEELLLLG RWEEEERDQY YYY------- SSHHTGGPDG VYSAPP--EE DDPPGFVVMM SSFDDLLLLG RWEEEERPQQ QQQ------- SSHHTLLASG EVVNDD--LL NNKKGVLLLL TTFEEKKKKG TWEEEEGASP PPP------- GGHHTLLASG EVISDD--PP NNKKGVLLLL TTFEEKKKKG TWEEEEGEAP PPP------- GGHHTLLASG EVISDD--SS NNKKGVLLLL TTFEEKKKKG TWEEEEGAAP PPP------- GGHHTLLPSG EVVSDD--PP NNKKGVLLLL TTFEEKKKKG TWEEEEGAAP PPP------- AAHHTLLASG EVISDD--VV NNKKGVLLLL TTFEEKKKKG TWEEEEGAAP PPP------- AAHHTLLASG EVISDD--VV NNKKGVLLLL TTFEEKKKKG TWEEEEGAAP PPP------- AAHHTLLASG EVISDD--VV NNKKGVLLLL TTFEEKKKKG TWEEEEGAAP PPP------- AAHHTLLASG EVISDD--VV NNKKGVLLLL TTFEEKKKKG TWEEEEGAAP PPP------- GGHHTLLPTG EVISDD--PP NNKKGVLLLL TTFEEKKKKG TWEEEEGSAP PPP------- ---------- ---------- ---------- ---------- ---------- ---------- AAHHTLLASG EVISDD--VV NNKKDLVVLL RRLEESSSSG ---------- ---------- GGHHTLLASG DIISDD--KK NNAAGFLLLL EEFNNKKKKG RGSSSSLPIS SSS------- AAHHTLLGCG EIISDD--PP NNKKGVLLLL TTFEEKKKKG NWEEEEGAAP PPP------- AAHHTLLGCG EIISDD--PP NNKKGVLLLL TTFEEKKKKG NWEEEEGSAQ QQQ------- AAHHTLLASG ELISDD--KK NNEEGFLLLL DDFNNKKKKG RWEEEEGSPL LLL------- AAHHTLLASG EIISDD--KK NNEEGFLLLL EEFNNKKKKG RWEEEEGSPL LLL------- AAHHTLLASG EIVSDD--EE NNKKGFLLLL DDFNNKKKKN RWEEEEGSPL LLL------- AAHHTRRT-G EIVSDD--EE NNKKGLLLLL DDFNNKKKKN RWEEEEDSPL LLL------- GGHHTLLASG EIISDD--KK NNAAGFLLLL EEFNNKKKKG RWEEEEGSPL LLL------- SSHHTLLADG NIISEE--AA TTSSGLLLLL TTFEEKKKKG TWPPPPETVP PPP------- SSHHTLLADG NIISEE--AA SSSSGLLLLL TTFEEKKKKG TWPPPPGVVP PPP------- ---------- ---------- ---------- ---------- ---------- ---------- TTHHTLLPNG NIISDD--AA NNKKGFVVEE NNFEEVVVVG TWSSSSDKAL LLL------- TTHHTLLANG NIISDD--AA YYKKGFIILL DDFNNIIIIG TWTTTTDKAL LLL------- AAHHTQQPNT ALQDEE--SS VVVVLIQQTT EENGGSSSSA KGEEEEQEEI III------- VVHHTLLPGS MMTGDD--DD GGRRTVEEYY GGEYYAAAAT YWMMMMADMQ QQQAAAVVVA VVHHTLLPGR MLTGNN--KK GGRRTVEEYY GGEYYAAAAT HWIIIIDDLR RRRAAAIIIK ---------- LAAYFWL-PP NNEEVLLLVS EEWAVVVP-T TTDDGG-LLK KKLLLEHKD- ---------- FAAYFWL-PP SSGGVMMMIS EEWTVVVP-C CCEEGG-FFS SSLLLECKEG ---------- KHHYFWL-PP RRDDYMMMVS EEWALLLP-Q QQNNGG-IIV VVPPPEDLAN ---------- LHHYFWL-PP RRDDYMMMVS EEWALLLP-Q QQNNGG-IIV VVPPPEDLSN ---------- KHHYFWL-PP RRDDYMMMVS EEWGLLLP-Q QQNNGG-IIV VVPPPEDLSN ---------- FAAYGWL-GG YYDDTLLLVS EEWGTTTP-M MMDDGG-LLV VVPPPDILGA ---------- LHHYFWL-GG YYDDTLLLLS EEWGTTTP-M MMSSGG-VVL LLGGGDELAG ---------- LAAYFWL-GG YYDDTMMMVS EEWGTTTP-M MMGGGG-LLD DDPPPQILNK ---------- MGGYFYP-RR HHNNVMMMVT EEWAAAAP-V VVDDGGFNNP PPAAAHVA-G ---------- MGGYFYP-RR HHNNIMMMVT EEWAAAAP-V VVDDGGFNNP PPAAAHVA-G ---------- MGGYFYP-RR HHNNVMMMIT EEWAAAAP-V VVDDGGFNNP PPAAADVA-G ---------- LGGYFYP-RR HHNNVMMMIT EEWAAAAP-V VVDDGGFNNP PPAAADVA-G ---------- SGGYFYP-RR HHNNVMMMIT EEWAAAAP-V VVDDGGFNNP PPAAADVA-G ---------- LGGYFYP-RR HHNNVMMMIT EEWAAAAP-V VVDDGGFNNP PPAAADVA-G ---------- LGGYFYP-RR HHNNVMMMIT EEWAAAAP-V VVDDGGFNNP PPAAADVA-G ---------- LGGYFYP-RR HHNNVMMMIT EEWAAAAP-V VVDDGGFNNP PPAAADVA-G ---------- MGGYFYP-RR HHNNVMMMIT EEWAAAAP-V VVNNGGFNNP PPAAADVA-G ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A IISAHHHS-L LLTTGGSRRD DDYYYPAA-S ---------- KEERHYNYAA WWGGLFFFWW IIQCCCCS-F FFTTGGAEEL LLMMMCLA-S ---------- FGGYFYP-RR HHNNVMMMIT EEWGAAAP-A AALLGGFKKM MMEEEEVA-G ---------- FGGYFYP-RR HHNNVMMMIT EEWGAAAP-A AALLGGFKKM MMEEEDVA-G ---------- FGGYFYP-RR HHNNTMMMIT SSWGAAAP-A AAKKGGFDDL LLQQQHVD-G ---------- FGGYFYP-RR HHNNTMMMIT SSWGAAAP-A AAQQGGFNNL LLQQQHVD-G ---------- FGGYFYP-RR HHKKTMMMIT SSWGAAAP-A AAKKGGFDDL LLQQQHVD-G ---------- YGGYFYP-RR HHKKTMMMIT SSWGAAAP-A AAKKGGFNNL LLQQQHVD-G ---------- FGGYYYP-RR HHKKTMMMIS SSWGAAAP-A AATTGGFDDL LLQQQHVD-G ---------- FNNYFYP-RR RRNNVMMMIT EEWGSSSP-H HHKKGGFNNP PPAAAHVE-G ---------- FNNYFYP-RR RRNNIMMMIT EEWGSSSP-H HHKKGGFNNP PPAAAHVE-G ---------- ---------- ---------I LLRGGGGP-T TTRRDDEEEL LLKKKCQE-P ---------- CGGYYYP-HH FFNNVMMMVS EEWGAAAP-L LLRRGGYHHP PPTTTDCDRT ---------- CGGYFYP-YY FFDDVMMMVS EEWGAAAP-K KKRRGGWKKN NNVVVDLDMS ---------- LQQLNNG--- RREEKSSSED RRPDEEEP-M MMEESSSEES SSFFFLKTGP GDVVADDGGG YGGYIAI-RR KKNNVMMMLS SSFTGGGWYM MMFFGGQMML LLQQQDAAMK G-YYADDGGG YDDYVAP-RR KKNNLLLLVS SSFTGGGWYM MMFFGGKMML LLAAADPAMK -RGHWWWWWD DLRKRLLEEN MMML--EELR HDDKKGFNNV SKSSSIWWYY -EGGKWWAAA GAGHWWWWWD DLAKRIIQQH MMML--EEVR HDDKKGFNNV NKSSSIWWYY -EGGKWWAAA NKGHWWWWWD DLRARIIAAH MMML--EEVR HDDRRGFGGV DTEGSIWWRR -EGGKFFVVV NKGHWWWWWD DLRARIIAAH MMML--EEVR HDDRRGFGGV DTEASIWWRR -EGGKFFAAA NKGHWWWWWK KLRDRIIAAH MMML--EEIR HDDKKGFGGV DTQGAIFWQQ KDGGTFFAAA ARGHWWWWWD DLTRRIIDDH LLLF--EELR HDDKKGFNNV SKSSSIWWRR -DDDKWWVVV GKGHWWWWWD DLYRRLLAAY MMML--EELR HDDKKGFNNV SKSASIWWRR -DGGSWWLLL KGGHWWWWWD DLRRRLLEEH MMML--EELR HDDRRGFGGV SESASVWWRR -QGGSWWIII GLGFWWWWWD DWQRHLL--D LLLP--EEIR HDDAAGFGGA SNRFYKNE-- ---------- GLGHWWWWWD DWQRHLL--D LLLP--EEIR HDDAAGFGGA SNRFYKNG-- ---------- GLGHWWWWWD DWQRHLL--D LLLP--EEIR HNNAAGFGGA STRFYKNG-- ---------- GLGYWWWWWD DWQRRLL--D LLLP--EEIR HNNAAGFGGA STRFFKND-- ---------- GLGYWWWWWD DWQHHLL--D LLLP--EEIR HNNAAGFGGA STRFYKNG-- ---------- GLGYWWWWWD DWQRHLL--D LLLP--EEIR HNNAAGFGGA STRFYKNG-- ---------- GLGYWWWWWD DWQRHLL--D LLLP--EEIR HNNAAGFGGA STRFYKNG-- ---------- GLGYWWWWWD DWQRHLL--D LLLP--EEIR HNNAAGFGGA STRFYKNG-- ---------- GLGHWWWWWD DWQRHLL--D HHHP--EEIR HDDAAGFGGA STRFYKNG-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SRA------- ---------- ---------- ---------- ---------- ---------- SGHCDDDDDN NYIMRLL--D AAAANICCLR HWWIIDYVVE SSGGSDPA-- ---------- GMGNWWWWWD DWTEHIIEED LLLP--EEIR HDDAAGLGGA STRFYKED-- ---------- GHGNWWWWWD DWTEHIIKKD LLLP--EEIR HNNAAGLGGA SSRFYKED-- ---------- GLGTIIIIIQ QLARGLLNNT LLLP--EEIR HDDKKGFGGA SNRFFKTD-- ---------- GLGHYYYYYS SWPGGLLDDK LLLP--EEIR HDDKKGFGGA TNRFFKTD-- ---------- GLGHYYYYYS SWPGGIIEET LLLP--EEIR HDDKKGYGGA SNRFFKND-- ---------- GLGHYYYYYS SWPGGIIPPT LLLP--EEIR HDDKKGFGGA SNRFFKND-- ---------- GLGHYYYYYD DWPGGLLSST LLLP--EEVR HDDKKGYGGA TNRFFKTD-- ---------- GLGHFFFFFE EWDSKIIQQL AAAP--EEVR HEESSAFGGA GGRIHPVESS ---------- GLGHFFFFFE EWDTKIIMMR AAAP--EEVR HEESSAFGGA GARIHPDKPP ---------- PLIRYYYYY- ---------- ---------- ---------- ---------- ---------- TQGNYYYYYR RWQERIIDDD LLLP--EEIR HNNEEGYGGA XXXXX----- ---------- SQGNYYYYYK KWSTQIISSD IIIP--EEIR HNNKKGFGGA NKHFKKKDDD ---------- PLPAVVVVVL L--------- ---------- ---------- ---------- ---------- KRGVWWWWWD DLHTRFFGGP ------EEIR WGGAAAFTTA TQLIYEDA-- ---------- KHGVWWWWWD DLHTKFFGGP ------EEIR WGGHHCFSSA TQLIYEDE-- ---------- KEAENLPELL APLVTTDIII DDLYLSSLWI RQQYINNKKL TGGGKVKKLL FHHHADP--- RDAEPLPPLL MPLVTTDIII DDLYVSSLWL RQQYINNQQL AGGGRVKKII YHHHEPP--- KTATELPPLL APLVTTDILL DDLYVSSCWT RQQYVDDNNL AGGGSVRRII ARRRAPP--- KTPPKLPPLL APLVTTDILL DDLYVSSCWT RQQYVDDKKL AGGGSVHHII ARRRTPP--- KTPDDLPDLL APLVTTDILL DDLYVAACWL HQQYVDDNNL TGGGKVEEII VKKKTPP--- KEADQLPPLL APLVTTDILL DDLYVSSCWT LQQYVDDEEL TGGGKVRRII VSSSATPGG- KDASQLPPLL APLVTTDILL DDLYVSSCWT HQQYVDDNNL TGGGKVQQII VRRRAGP--- KEAEQLPPLL APLVTTDILL DDLYVSSCWT RQQYVDDNNH TGGGSVRRLL VRRRAAP--- -WEQSKKVGG EPLITTDILL DDLYFSSNWH RQQYINNKKL TGGGQIFFLL IVVVGGVQQL -WEQSKKVGG EPLITTDILL DDLYFSSNWH RQQYINNKKL TGGGQIFFLL IVVVGGVQQL -WEQPKKVGG EPLITTDILL DDLYFSSNWH RQQYIDDRRL TGGGQLFFLL IVVVGGVQQL -WQQPKKVGG EPLITTDILL DDLYFSSNWH RQQYVDDRRL TGGGQLFFLL IVVVDGVQQL -WEQPKKVGG EPLITTDILL DDLYFSSNWH RQQYIDDRRL TGGGQLFFLL IVVVGGVQQL -WEQPKKVGG EPLITTDILL DDLYFSSNWH RQQYIDDRRL ---------- ---------- -WEQPKKVGG EPLITT---- ---------- ---------- ---------- ---------- -WEQPKKVGG EPLITTDILL DDLYFSSNWH RQQYIDDRRL TGGGQLFFLL IVVVGGVQQL -WEEPKKVGG EPLITTDILL DDLYFNNNWH RQQYIDDRRL VGGGQIFFLL IVVVGGVQQL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -VKDYAVVKK SSEFPPPAII SSIIFLLS-- ---------- ---------- ---------- -WEKSKKVGG EPLITTDIII DDLYFSSNWH RQQYIDDNNL VGGGQIFFLL ILLLGGVTTL -WEQSKKVGG EPLITTDIII DDLYFSSNWH RQQYIDDNNL VGGGQIFFLL IQQQGGVTTL -WEPPLKVNN EPLITTDFII DDLYFVVNWH RQQYIDDNNL TGGGQLWWVV IQQQGSVAAI -WESPLKVNN EPLITTDFII DDLYFVVNWH RQQYIDDNNL TGGGQVWWAA IQQQGSVVVV -WESPLKVNN EPLITTDFII DDLYFVVNWH RQQYIDDNNL TGGGQIWWVV LQQQGSVKKV -WESPLKVNN EPLITTDFII DDIYFVVNWH RQQYIDDNNL TGGGQIWWVV LQQQGSVKKV -WESPLKVNN EPLITTDFII DDLYLVVNWH RQQYIDDKKL AGGGQVWWAA LQQQGSVVVV THTFSKKVGG EPLITTDIII DDLYVSSCWH RQQYIDDKKL NSSSQVYYII VHHHESVKKL KQSTSKKVNN DPLITTDIII DDLYVSSCWH RQQYIDDNNL NSSSQVFFII IHHHETVKKL ---------- ---------- ---------- ---------- ---------- ---------- ------QGNN MGMMTTDIII DDLYFSSNWH RQQYIDDNNL TGGGQVFFLL IQQQDARRRL EAVPLVDTSS DGMISSDIII DDLYVNNCWH RQQYIDDNNL TGGGQLFFLL ICCCDLNVVV ---------- ---------- ---------- ---------- ---------- ---------- ---EAKAVDD AILPVVDIII DDLWINNSFD RLLFIDDKKQ IYYYEKVVII VNNN------ ---EAKAVDD AVLPVVDIII DDLWVNNTFD RLLFIDDHHQ VYYYEKTTII VNNN------ ---------- -----AAHLL AAPPPPLLLE EDDRVYVSYY SNQQQQFFYE EEGLGMKKLL ---------- -----SSAAA AAPPPPIIIS SDDRVYISYY SNQQQQFFY- --GLGMKKVV ---------- -----NNRFF GGPPPPVVVE EDDRVYWSYY SDQQQQFFYD DDGVAQLLAA ---------- -----NNKFF GGPPPPVVVE EDDRVYWSYY SDQQQQFFYD DDGVGEMMAA ---------- -----NNKFF GGPPPPVVVE EDDKVYWSYY SEQQQQFFYG GGDRAMMMAA ---------- ----AKKGLL GGPPPPVVVE EDDRVYFSYY GPQQQQFFYE EEGIGMKKLL ---------- ----ATTALL GGPPPPVVVE EDDRVYFSYY REQQQQFFYD DDGIGMKKVV ---------- -----AAGLL GGPPPPVVVE EDDRVYFSYY AEQQQQFFYV VVGIGIKKAA E-DDQQQETC CQEPVKKKII GGPPPPIIIQ QDDKLYASYY SKQQQQFFYP PPDLRGVVMM E-DDQQQETC CQEPVKKKVV GGPPPPIIIQ QDDKLYVSYY SKQQQQFFYP PPNLRGVVMM E-DDQQQEKS SQEPVKKKVV GGPPPPIIIQ QDDKLYVSYY SKQQQQFFYP PPDLRGVVMM D-DDQQQEDS SQEPVKKKVV GGPPPPIIIQ QDDKLYVSYY SKQQQQFFYP PPDLRGVVMM E-DDQQQEKS SQEPVKKKVV GGPPPPIIIQ QDDKLYISYY SKQQQQFFYP PPDLRGVVMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- E-DDEEEEKS SQEPVKKKVV GGPPPPIIIQ QDDKLYISYY SKQQQQFFYP PPDLRGVVMM E-DDQQQEKS SQEPVKKKVV GGPPPPIIIQ QDDKIYVSYY SKQQQQFFYP PPDLRGVVMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- E-DDKKKDEC CQDPVKKKVV GGPPPPIIIQ QDDKLYVSYY SKQQQQFFYP PPDMKGVVMM E-DDKKKEEC CQDPVKKKII GGPPPPIIIQ QDDKIYVSYY SKQQQQFFYP PPDLKGVVMM G-EEDDDGTW WQDVIQQQLL GGPPPPIIIQ QDDKLYVSFF SKQQQQFFYP PPGLEGHHII K-DDDDDGTW WQDVIQQKLL GGPPPPIIIQ QDDKLYVSFF SKQQQQFFYP PPKLEGHHII G-EEDDDGSF FQDVIKKKLL GGPPPPIIIQ QDDKLYASFF SRQQQQFFYP PPELDGHHII G-EEDDDGTF FQEVIKKKLL GGPPPPIIIQ QDDKLYASFF SVSSSSFFYP PPEIEGHHII T-EEDDDDEE EQSVVKKHLL GGPPPPIIIQ QDDKIYVSFF SEQQQQFFYQ QQDLKGHHMM E-GGEEEK-- -PEAVKKRII GGPPPPLLLQ QDDKLYVSYY KDQQQQFFYP PPEHKGTTMM E-EEDDDH-- -EPAVKKRII GGPPPPLLLQ QDDKLYVSYY KDQQQQFFYP PPENRGTTMM ---------- ---------- GGPPPPIIIQ QDDKLYVSYY SKQQQQFFYP PPNVKGVVMM N-DDPPPEKE EAEPLKKRLL GGPPPPLLLQ QDDRLYVSFF SKQQQQFFYP PPEMAGTTII KEDDKKKEKE ERPAVKKRLL GGPPPPLLLQ QDDKLYVSYY SKQQQQFFYP PPKMSGHHII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------VVVS SDDKVYFSLL A--------- ----KGDDDD ---------- ---------- ------VVVS SDDQLYYSLL A--------- ----KGDDDD A-------SS GLEIDDDKKK EEEFVDGGG- ------ARSQ RLGGDAASSS SDSSYYYY-- V-------EE GLELEEEKKK EEEFVDGGG- ------ARAQ RLGGDAASSS TDSSFFFY-- A-------DD GLTLAAADDD DDDYVEPPPG G-----YRAQ RLGGDCCSSS TDSSFFFYSV V-------NN GLELDDDKKK DDDYVSPPPG G-----YRAQ RLGGDCCSSS TDSSFFFYSV V-------NN GLTLDDDKKK DDDFVDPPPG G-----YRSQ RLGGDCCSSS TDSSFFFYSV A-------NN GIEFDDDPPP KKKFLEPPPG G-----HRPQ RLGGDCCSSS SDSSYYYY-- V-------DD GMQFDDDPPP NNNFVDGGG- ------QRVQ RLGGDAASSS SDSSYYYF-- A-------GG GLSLDDDPPP GGGFTEGGGG G-----LRPQ RLGGDSSSSS SDSSYYYYS- QVDDTTTTNN GLKLNNNPPP NNNFVDGGGE EPLGGPALAE RYGGDCCSSS SDIIWWW--- QVDDTTTTNN GLKLNNNPPP NNNFVDGGGE EPLGGPALAE RYGGDCCSSS SDIIWWW--- QVDDTTTTKK GLKLNNNPPP NNNFVDGGGE EPLGGPALAE RYGGDCCSSS SDIIWWW--- QVDDTTTTKK GLTLNNNPPP NNNFVDGGGE EPLGGPALAE RYGGDCCSSS SDIIWWW--- QVDDTTTTKK GLKLNNNPPP NNNFVDGGGE EPLGGPALAE RYGGDCCSSS SDIIWWW--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QVDDTTTTKK GLKLNNNPPP NNNFVDGGGE EPLGGPALAE RYGGDCCSSS SDIIWWW--- QVDDTTTTKK GLKLNNNPPP NNNFVDGGGE EPLGGPALAE RYGGDCCTTT SDIIWWW--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QVDDTTTTKK GLKLNNNPPP NNNFVDGGGE EPGGGPVLAE RYGGDCCSSS SDIIWWW--- QVDDTTTTKK GLKLNNNPPP NNNFVDGGGE EPDGGPVLAE RYGGDCCTTT SDIIWWW--- QVDDTTTTKK GLKINNNPPP NNNFVDGGGE EPDGGPALAE RYGGDCCTTT SDIIWWW--- QVDDTTTTNN GLKINNNPPP NNNFVDGGGE EPDGGPSLAE RYGGDCCTTT SDIIWWW--- QVDDTTTTKK GLSINNNPPP NNNFVDGGGE EPEGGPALAE RYGGDCCTTT SDIIWWW--- QGDDTTTTKK GLTINNNPPP DDDFVDGGGE EPDGGPSLAE RYGGDCCTTT SDIIWWW--- QVDDTTTTKK GLSINNNPPP NNNFVDGGGE EPEGGPSLAE RYGGDCCTTT SDIIWWW--- QIDDPPPPSS GMEINNNRRR DDDFIDGGGI IEGGGPYLAE RYGGDCCTTT SDIIWWW--- QVDDPPPPTT GMVINNNKKK NNNFIDGGGV VPGGGPYLAE RYGGDCCTTT SDIIWWW--- QVDDTTTTKK GLTVNNNKKK NNNFVDGGGE EPNGGPCLAD RFCGDSSTTT SDIILLL--- QIDDVVVVNN GMKLNNNEEE NNNFVDGGGE EPYGGPGLPE R--------- ---------- LVDDTTTTNN GISLNNNEEE DDDFVDAAAE EPYGGPSLPE RYGGDCCTTT SDIIWWWADA ---------- ---------- ---------- ---------- ---------- ---------- QKAAYYYYWW DKELVVVEEE DDDFVDYYYL LGLGG--RAI RFSSALLYYY SS-------- QKLLYYYYWW DKELKKKEEE QQQFIDYYYE EKLGG--RPQ RFARALLYYY AGPPAAADNR ------- ------- VVRRRR- VV----- VV----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AA----- ------- ------- RRVVVVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNSSKAAASA RRRTAVVPTT GGLLTTARLL LAAGMMLLTA AQPGSVRKKY YYQQEAAWWT gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------M MMAAGRRAAP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TSSAIQVVLS SSSPRRSEES KKVPGSVVAA AQQVVPSQQA AAVVQQWWLL PKHGGGGAVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EAEGGGGFTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------GLL KEPGGGGTAA ---------- ---------- ---------- ---------- ------LNSS GLGFFFFQTT ---------- ---------- ---------- ---------- ---------- ---------- PLLPLNNNRP TTTPHHPNNP AAHPRLRRPP PRRTTNVPPP PPLLPPCHAA HLVLLLLHII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MM REFGGGG--- ---------- ---------- ---------- ---------- --------MM RIVSSSSPSS ---------- -------MAV PPFKRRDDDT TYPKMMMMKK AAPPYYVVAL LLTGGNRAAI ---------- ---------A KKLKPPDDDT TYPRDDDDRR AAPPYYVVAL LLVGGNAPPL ---------- ---------M SSMRPPDDDT THPELLLLQQ AAPPYYTTLL LLPSS-RPPL ---------- ---------M TTMRPPDDDT THPKLLLLEE AAPPYYTTLL LLPSS-KPPL ---------- ---------M TTLRPPDDDT TYAKLLLLEE GGPPFFTTLL LLPSS-KPPL ---------- ---------A TTWKPPDDDS SYPRLLLLKK AAPPYYVVAF FFPKK-QPPI ---------- ---------V TTWRPPDDDT TYPRMMMMKK AAPPYYVVVL LLPNN-KPPM ---------- ---------A SSWRPPDDDT TYPKMMMMQQ AAPPYYVVAL LLPEE-RPPL ---------- --MAAAATKT KK--CCGGGG GPLEAAAA-- GGPPYYLLPI IIRGGEAPPL ---------- ---------- ---------- ---------- GGPPYYLLPI IIRGGEAPPL LLIAGLPPGG --HSSSSTQG KK--CCGGGG GPLEAAAA-- GGPPYYLLPI IIGGGEAPPL ---------- ---------- ---------- ---------- GGPPYYLLPI IIRGGEAPPL ---------- --MAAAATKG NN--CCGGGG GSLEAAAA-- GGPPYYLLPI IIRGGEAPPL LLQSPRPPII AATAAAATKG NN--CCGGGG GSLEAAAA-- GGPPYYLLPI IIRGGEAPPL ---------- --MAAAATKG NN--CCGGGG GSLEAAAA-- GG-------- -----EAPPL ---------- --MAAAATKG NN--CCGGGG GSLEAAAA-- GGPPYYLLPI IIRGGEAPPL QQPWGLWWQQ EETAAAATKG DD--CCGGGG GPQEAAAA-- GGPPYYLLPI IIRGGEAPPL NNTEYTLLVV FFSPPPPTKG NN--CCGGGG GSLEAAAA-- GGPPYYLLPI IIRGGEAPPL ---------- --MAAAATKG NN--CCGGGG GSLEAAAA-- GGPPYYLLPI IIRGGEAPPL MMEGVTAAAA AANGGGGKTC HHTAKKGGGG GALEAAAAKK GGPPYYVVTV VVNGGNKLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMMMAKG SS--CCGGGG GKLDAAAA-- GGPPYYLLPI IIRGGNKPPL MMATHVVVNN EEKSSSS-VG CCCKSSGGGG GAIESSSS-- GGPPYYVVTV VVAGGEKPPL MMGTHVVVSS EEVNNNNNQG CCCKSSGGGG GALEAAAA-- GGPPYYVVTV VVAGGEKPPL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M LLQVGGGGGG GALAAAAA-- GGPPYYVVTV VVTGGDKPPL -----MAAAA AANGGGGAAC GGGATTGGGG GALEAAAAKK GGPPYYVVTV VVNGGNKPPL ------MMSS PPCGGGGLKH GG----GGGG GAADAAAA-- GGPPFFVVTP PP-AADGPPI ------MMPP --CPPPPLKH GG----GGGG GAADAAAA-- GGPPFFVVTP PP-AADGPPI ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MSS KKCKCCGGGG GALDAAAANN GGPPYYVVVV VVPDDEHGGL ---------- ---------- ---------- --------SS GGPPYYTTVV VVPDDPHGGL ---------- ---------- ------MMMG GI-DIIIISS LLDDFFSSNL LLGRRYDIIR ----AAAAGG --LAAAAMGP FFRAFFAAAE ECPYMMMMII TTGGYYVVWL LLVMMDEQQL MMHFAVSSGG LLLAAAALAP AAGVRRAAAE ECPYMMMMII TTGGYYVVWL LLAVVDEQQL AVVVNPPPKS EYSSIIVKKK PDLHFWNNNN ACSALLC-NG G-KKKKIIIR RRFLLPGLLR AVVVDPPPKS PYGGVVIKKK PDLHFWNNNN ACSAYYC-NA A-KKKKLLLR RRYLLPALLR AVVIKPPPGS SYGGIIVTTT PDFHFWNNNN ACSSLLS-LT TGHHHHLLLR RRFLLPGLLR AVVIKPPPGS PYGGIIVTTT PDFHFWNNNN ACSALLS-LA AGHHHHIIIR RRYLLPGLLR AVVVDPPPTS EFGGIIVQQQ PDFHFWNNNN ACSALLS-LT TGHHHHLLLR RRYLLPGIIR AVVVDPPPAS PYAAIIVQQQ PDLHFWNNNN ACSCLLC-NA APHHHHMMMR RRYLLPGLLR CVVVDSSSQS SFGGVVVVVV PGLHFWNNNN ACSMLLC-NA APHHHHVVVR RRYLLPDIIR GVVLDPPPDS GYAAIIVRRR PDLHFWNNNN ACSALLC-YA APHHHHVVVR RRYLLPGIIR ATTVDPPPKS PYSSVVIRRR PDLHSWNNNN TCSC-----F FGDDDDKKKN NNKLLPGLLM ATTVDPPPKS PYSSVVIRRR PDLHSWNNNN TCSC-----F FGDDDDKKKD DDKLLPSIII ATTVDPPPKS PYCCVVIRRR PDLHSWNNNN ACSC-----F FGDDDDKKKT TTKLLPCLLM ATTVDPPPKS PYCCVVIRRR PDLHSWNNNN TCSC-----Y YGDDDDKKKT TTKLLPALLI ATTVDPPPKS PYCCVVIRRR PDLHSWNNNN TCSC-----F FGDDDDKKKT TTKLLPSLLI ATTVDPPPKS PYCCVVI--- ---------- ---------- ---------- ---------- ATTVDPPPKS PYCCVVIRRR PDLHSWNNNN TCSC-----F FGDDDDKKKT TTKLLPSLLI ATTVDPPPKS PYCCVVIRRR PDLHSWNNNN TCSC-----F FGDDDDKKKT TTKLLPSLLI ATTVDPPPKS PYSSVVIRRR PDLHSWNNNN TCSC-----F FGDDDDKKKN NNKLLPSFFI ATTVDPPPKS PYCCVVIRRR PDLHSWNNNN TCSC-----F FGDDDDKKKT TTKLLPSLL- ATTVDPPPKS PYCCVVIRRR PDLHSWNNNN TCSC-----F FGDDDDKKKT TTKLLPSLLI ATTVDPPPSS PYSSVVIRRR IDLHSWNNNN SCSC-----H HGDDDDAAAR RRFLLPSLLL ---------- ---------- PDLHSWNNNN TCSC-----Y YGDDDDKKKN NNKLLPCLLI ATTVDPPPKS PYSSVVIRRR PDLHSWNNNN TCSC-----Y YGDDDDKKKN NNKLLPCLLI ATTVDPPPSS PYSSVVIRRR PDLHTWNNNN SCSC-----H HGDDDDAAAR RRFLLPSLLV ATTVDPPPNS PYSSVVIRRR PDLHTWNNNN SCSC-----H HGDDDDAAAR RRFLLPGIIV ---------- ---------- PDLHSWNNNN SCSC-----H HGDDDDAAAR RRYLLPSLLI ATTVDPPPSS PYSSVVIRRR PDLHSWNNNN SCSC-----H HGDDDDVVVR RRYLLPSLLI GTTVDPPPNS PYSSVVIRRR TDLHSWNNNN ACSC-----H HGDDDDAAAR RRFLLPSLLL FTTVNPPPES DFCCVVIRRR PDVHTWNNNN ACSC-----H HDKKKKEEES SSHLLPCLLN FTTVNPPPES EFCCIIIRRR PDVHTWNNNN ACSC-----H HDKKKKEEES SSHLLPCLLN ---------- ---------- ---------- ---------- ---------- ---MMRKLLS ATTVDPPPAS PYCCVVIRRR NNLHSWNNNN TCSCHHFV-G GGKKKKPPPD DDRLLPCLLN STTVDPPPES PYCCIIVRRR NDLHSWNNNN ACSCYYYVES SSKKKKPPPD DDRLLPSLLN KNNPVGGGQV FGGGVVLDDD KDEDSPTTTT PRIK------ -GKKKKQQQP PPQMMLSLLD VTTIRPPPGS ARGGVVISSS GNAHGFSSSS A--------- ---------R RRFFFGGLLD VTTVNPPPKS PYGGVVVTTT GNAHSFTTTT D--------- ---------R RRYLLGGLLD RSSRRIYYYI IIPPPPPPII IIKVIEEKVV VVGYYHTVGG GGGPDIIIII SSSAAALNNN RSSRRIYYYI IVPPKKKPVV VVKIVEVGRR RRGYYHTVGG GGGPDIIIII SSSAAALGGG RSSRRIYYYV VIPPPPPAII IIKIIDEAKK KKGYYHTVGG GGGPEIIIVV SSSTTTLGGG RSSRRIYYYI IIPPPPPAII IIKIIEEKKK KKGYYHTIGG GGGPDIIIVV SSSTTTLGGG RSSRRIYYYI IV--PPPAII IIKIIEEAKK KKGYYHTIGG GGGPEIIIVV SSSTTTLGGG RSSRRIYYYI ILPPPPPPLL LLKVIETERR RRGYYHTVGG GGGPGIIIVV TTTAAALNNN RSSHHITTTI ILPPPPPPVV VVKVINEERR RRGYYHTVGG GGGPDIIIII SSSAAALSSS RSSRRIHHHI IVPPPPPPII IIKVIEERRR RRGYYHTIGG GGGPDVVVVV SSSAAALSSS MSSRRIYYYV VVSSPPPPLL LLKVISEAKK KKNVVHTSLL LLLASEEEMM VVVNNNTGGG ISSRRIYYYV VVSSPPPPLL LLKVINEAKK KKNLLHTSLL LLLASEEEMM IIISSSSGGG MSSRRIYYYV VVSSPPPPLL LLKVIEDAKK KKGLLHTSLL LLLASEEEMM IIISSSTGGG ISSRRIYYYV VVTTPPPPLL LLKVIKDTKK KKNLLHTSLL LLLPSEEEMM VVVSSSTGGG ISSRRIYYYV VVSSPPPPLL LLKVIEDAKK KKELLHTSLL LLLASEEEMM IIISSSSGGG ---------- ---------- -----KDAKK KKELLHTSLL LLLASEEEMM IIISSSSGGG ISSRRIYYYV VVSSPPPPLL LLKVIKDAKK KKELLHTSLL LLLASEEEMM IIISSSSGGG ISSRRIYYYV VVSSPPPPLL LLKVIKDAKK KKELLHTSLL LLLASEEEMM IIISSSSGGG ISSRRIYYYV VVTTPPPPLL LLKVIKDEKK KKGLLHTSLL LLLPTEEEMM IIISSSTGGG ---------- ---------- ---------- ---------- ---------- ---------- ISSRRIYYYV VVSSPPPPLL LLKVIKDAKK KKELLHTSLL LLLASEEEMM IIISSSSGGG LSGRRVYYYV VVTTPPPPLL LLKVVEDENN NNGLLHTSLL LLLASDDDMM IIISSSCGGG ISSRRIYYYV VVTTPPPPII IIKTVYEWKK KKGLLHTSLL LLLGCEEEMM IIISSSSGGG ISSRRIYYYV VVSSPPPPII IIKTVYEWKK KKGLLHTSLL LLLGCEEEMM IIISSSSGGG VSGRRIYYYV VITTPPPPLL LLKVVADQKK KKGLLHTSLL LLLASEEEMM IIISSSCGGG VSGRRVYYYV VITTPPPPLL LLKVVEDTKK KKGLLHTSLL LLLASEEEMM IIISSSCGGG ISGRRIYYYA AIEEPPPPLL LLKYVKEEKK KKGLLHTALL LLLASEEELL VVVSSSCGGG ISGRRIYYYA AIEEPPPPLL LLKYVKEDKK KKGLLHTARR RRRT-EEELL VVVSSSCGGG LSGRRVYYYV VVKKPPPPLL LLKVVEDEKK KKGLLHTSLL LLLASEEEMM IIISSSCGGG NSDRRIYYYI IINN---ILL LLHTISKSLL LL-LLHTSLL LLLADNNNMM IIISSSTGGG NSDRRIYYYV VINN---ILL LLHTISKALL LL-LLHTSLL LLLADNNNMM IIISSSTGGG SSGVVEGGGK KVGG------ ---------- ---------- ---------- ---------- NSDRRIFFFV VITTPPPPLL LLKVI-DKGG GGDCCHTTLL LLLPNNNNMM IIISSSIGGG NSDFFIYYYI ILTTPPPPII IIKTI-DKSS SSNVVHTTLL LLLANNNNMM IIISSSVGGG DGKRRLYYYV VTYYAAAKFF FFP---DKFF FFVLLHTAQQ QQQPNAAAKK QQQDDDGNNN DTNRRIFFFI IFSSPPPPLL LLKTI-FDSS SSGVVHTFLL LLLPGMMMII TTTGGGLNNN DTSKKIFFFV VFSSPPPPLL LLKTI-FKSS SSGVVHTLLL LLLPGMMMII TTTGGGLNNN E--PPPGGID DDDFEEPLLL GGGWEIDDRR Q--------- -LLAYYYYYD DWWWW---NE P-RPPPGGID DDDFEEPIII GGGWEVYYRR Q--------- -FFAYYYYYD DWWWW---SG AKTAAAPGID DDDFDDVLLL GGGWEIDDRR Q--------- -KKHYYYYYD DWWWW---RD GKTPPPPGVD DDDFEEVLLL GGGWEIDDRR Q--------- -LLHYYYYYD DWWWW---RD GETPPPPGID DDDFEEILLL GGGYEMDDRR Q--------- -KKHYYYYYD DWWWW---RD A--PPPGGID DDDFEEPLLL GGGWEVEERR Q--------- -FFAYYYYYD DWWWW---YD P--PPPGGID DDDLEEVLLL GGGWEIDDRR Q--------- -LLHYYYYYD DWWWW---YD P--PPPGGVD DDDFDDPLLL GGGWEVEERR Q--------- -LLAYYYYYD DWWWW---YD D-GKKKGSFD DDDFEEVKKK GGGWEKPPGG S--------- -MMGYYYYYD DWWWY---HN D-GKKKGGFD DDDFEEVKKK GGGWEKPPGG A--------- -MMGYYYYYD DWWWY---HN D-GKKKGGFD DDDFEEVKKK GGGWEQPPGG A--------- -MMGYYYYYD DWWWY---HN D-GKKKGGFD DDDFEEVKKK GGGWEQPPGG A--------- -LLGYYYYYD DWWWY---HN D-GKKKGGFD DDDFEEVKKK GGGWERPPGG A--------- -SSGYYYYYD DWWWY---HN D-GKKKGGFD DDDFEEVKKK GGGWERPPGG A--------- -LLGYYYYYD DWWWY---HN D-GKKKGGFD DDDFEEVKKK GGGWERPPGG A--------- -LLGYYYYYD DWWWY---HN D-GKKKGGFD DDDFEEVKKK GGGWERPPGG A--------- -LLGYYYYYD DWWWY---HN D-GKKKGGFD DDDFEEVKKK GGGWERPPGG A--------- -MMGYYYYYD DWWWY---HN ---------- ---------- ---------- ---------- ---------- ---------- D-GKKKDGSL LLLLEECSSS GGG------- ---------- ---------- ---------- D-GAAAGNGL LLLFNNVKKK GGGGSNRRLL I--------- -KKERRRRRT TLLLYYYYWG D-GKKKGGFD DDDFEEVKKK GGGWEAEEGG A--------- -FFGYYYYYD DWWWY---HN D-GKKKGGFD DDDFEEVKKK GGGWEVEEGG A--------- -FFGYYYYYD DWWWY---HN D-GEEEGNGL LLLFNNVKKK GGGWEKPPGG P--------- -FFGYYYYYD DWWWY---HN D-GEEEGNGL LLLFNNVKKK GGGWEKPPGG P--------- -FFGYYYYYD DWWWY---HN D-GKKKGNGL LLLFNNIKKK NNNWEKPPGG P--------- -FFGYYYYYD DWWWY---HK D-GKKKGNGL LLLFNNIKKK NNNWEKPPDD P--------- -YYGYYYYYH HWWWY---HK D-GAAAGNGL LLLFNNVKKK GGGWEKPPGG P--------- -FFGYYYYYD DWWWY---HK E-GSSSGNFD DDDFEEPKKK GGGWPADDEE V--------- -FFNYYYYYD DWWWY---RN E-GSSSGNFD DDDFEEPKKK GGGWPADDGG V--------- -FFNYYYYYD DWWWY---RN ---------- ---------- ---------- ---------- ---------- ---------- D-GKKKG-DF FFFFEELVVV GGGWSRGGDD A--------- -CCGYYYYYD DWWWY---FN D-GKKKG-DF FFFFNNCIII GGGWTKGGDD A--------- -CCGYYYYYD DWWWY---FD E-SVVVLNGS SSSNGGLSSS AAAGEASSQQ E--------- -LLQLLLLLS SHHHN---RE D-HRRRTALN NNNEYYVAAA TTTWMPTTAA MGAVVGGDDA DYYGYYYYYD DRRRA---KN N-HRRRTALT TTTEYYVAAA TTTWIPTTDD LGAIIGG--A DYYDYYYYYD DRRRA---KN EEVSSSSWAV VVPPNN---T TEEDDGKLHL LKKDDRNNNR IFDKRRHHSL EEENRMMMA- GGVTTTSWTV VVPPRR---C CEEEEGSLCL LKKEEANNNK LVDKRHYYAI QQEHRMMMV- DDYSSSSWAL LLPPPP---Q QEENNGVPDL LLLAAKHHHR LFDARNQQTI AAQHQMMMA- DDYTTTSWAL LLPPPP---Q QEENNGVPDL LLLSSKHHHR LFDARNQQTI AANHQMMMA- DDYSSSSWGL LLPPPP---Q QEENNGVPDL LLLSSKHHHK IFKDRNQQTI AANHQMMMA- DDTTTTSWGT TTPPDD---M MEEDDGVPIL LLLGGRRRRR LFDRRHQQEI DDEHQLLLV- DDTTTTSWGT TTPPRR---M MEESSGLGEL LLLAAKHHHR LVDRRHQQTL AAEYQMMMA- DDTTTTSWGT TTPPNN---M MEEGGGDPIL LLLNNGRRRR LIDRRHQQAL EEEHQMMMV- NNVSSSTWAA AAPPNN---V VKKDDGPAVE EAA--LSSSR IVDRHIQQTL ---DGLLLI- NNISSSTWAA AAPPNN---V VKKDDGPAVE EAA--LSSSH IVDRHIQQTL ---DGLLLI- NNVSSSTWAA AAPPNN---V VRRDDGPAVE EAA--LSSSH LVDRHIQQTL ---DGLLLI- NNVSSSTWAA AAPPNN---V VRRDDGPAVK KAA--LSSSH LVDRRIQQTL ---DGLLLI- NNVSSSTWAA AAPPNN---V VRRDDGPAVE EAA--LSSSH LVDHHIQQTL ---DGLLLI- NNVSSSTWAA AAPPNN---V VRRDDGPAVE EAA--LSSSH LVDRHIQQTL ---DGLLLI- NNVSSSTWAA AAPPNN---V VRRDDGPAVE EAA--LSSSH LVDRHIQQTL ---DGLLLI- NNVSSSTWAA AAPPNN---V VRRDDGPAVE EAA--LSSSH LVDRHIQQTL ---DGLLLI- NNVSSSTWAA AAPPNN---V VQQNNGPAVE EAA--LKKKH LVDRHIQQTL ---DGHHHI- ---------- ---------- ---------- ---------- ---------- ---------- ------ASAH HHSSNN---L LLLTTGDYAS SAA--RGGGI T--------- ---------- GGLSSSWQCC CCSSLL---F FTTTTGLMLT TAA--GVVVI SLNMRIEESL ---DQAAAGI NNVSSSTWGA AAPPKK---A AAALLGMEVQ QAA--MHHHS LVDEHRQQTI EE-DGLLLI- NNVSSSTWGA AAPPKK---A AAALLGMEVQ QAA--HHHHS LVDEHLQQTI KK-DGLLLI- NNTSSSTWGA AAPPTT---A ATTKKGLQVA ADD--LRRRH LCQRGLQQTL NN-TGLLLL- NNTSSSTWGA AAPPKK---A ALLQQGLQVA ADD--LRRRH LVSGGIQQTL DD-KGLLLL- KKTSSSTWGA AAPPKK---A ASSKKGLQVA ADD--LSSSH LVSGGMQQLI EE-TGLLLL- KKTSSSTWGA AAPPKK---A ASSKKGLQVA ADD--LSSSH LVSGGIQQLI PP-TGLLLL- KKTSSSSWGA AAPPAA---A ARRTTGLQVQ QDD--LRRRH LVDGGLQQTL SS-TGLLLL- NNVSSSTWGS SSPPNN---H HKKKKGPAVG GEE--LNNNS VIESKYQQTI QQPLGAAAL- NNISSSTWGS SSPPNN---H HKKKKGPAVP PEE--LNNNS VIETKHQQTI MMPRGAAAL- ---SSSIRGG GGPPVV---T TCCRRDLKQP PEE--LKKKC KV-------- ---------- NNVAAASWGA AAPPKK---L LRRRRGPTCD DDDRRQCCCR LFRERLQQTI DD-DGLLLT- DDVSSSSWGA AAPPNN---K KRRRRGNVLE EDDMMQCCCR LFKTQLQQTI SS-DGIIIT- EEKSSSDPDE EEPPII---M MFFEESSFKK KTTGGLQQQH VEL------- ---------- NNVTTTSFTG GGWWSSYYYM MDDFFGLQAE EAAMMRNNNT IQDTRPKKVF GGAP------ NNLTTTSFTG GGWWNNYYYM MDDFFGLAPE EAAMMHNNNT VTDTKPKKVF GGAP------ -LDPLLLGGG FIINNSKDLS SSSSILLWWW F-GKKKKAAA KKVVIIIAEP G--LLPPPEE -LDPLLLGGG FVVNNNKDLS SSSSILLWWW F-GKKKKAAA RRVVIIIAQP G--LLPPPPP -ADPEEEGGG FVVGGDTNLE SSSSITTWWW W-GKKKKVVV KKTTAAIAEP ADDLLPPPPP -ADPEEEGGG FVVGGDTNLE SSSSITTWWW W-GKKKKAAA KKTTAAIPEP KEELLPPPPP -ADPDDDGGG FCCGGDTNLQ AAAAITTWWW WKGTTTTAAA KKTTIIIPVP ADDLLPPPDD -ADPAAAGGG FVVNNSKDLS SSSSITTWWW Y-DKKKKVVV KKVVIIIAEA PDDLLPPPPP -ADPAAAGGG FMMNNSKDLS SSSSILLWWW Y-GSSSSLLL KKVVIIIAEP EDDLLPPPPP -ADPTTTGGG FVVGGSEDLS SSSSVLLWWW H-GSSSSIII KKVVIIIAEP PDDLLPPPPP LLDPTTTGGG FVVGGSNIQR YYYYKEEEEE G--------- ----TTSEKV VPPKKKKKVV LLDPTTTGGG FVVGGSNIQR YYYYKEEGGG G--------- ----TTSEKV VPPKKKKKVV LLNPAAAGGG FVVGGSTIQR YYYYKQQGGG G--------- ----TTSEKV VPPKKKKKVV LLNPAAAGGG FVVGGSTIQR FFFFKEEDDD G--------- ----TTSQKV VPPKKKKKVV LLNPAAAGGG FVVGGSTIQR YYYYKEEGGG G--------- ----TTSEKV VPPKKKKKVV LLNPAAAGGG FVVGGSTIQR YYYYKEEGGG G--------- ----TTSEKV VPPKKKKKVV LLNPAAAGGG FVVGGSTIQR YYYYKEEGGG G--------- ----TTSEKV VPPKKKKKVV LLNPAAAGGG FVVGGSTIQR YYYYKEEGGG G--------- ----TTSEKV VPPKKKKKVV LLDPSSSGGG FVVGGSTIQR YYYYKEEGGG G--------- ----TTSEKV VPPKKKKKVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LIWKNNNDDD YDDVVSSGRG SSSSDDDAAA Y--------- ----AAVKRK LYYAAVVVVV LLDPAAAGGG LVVGGSTVFR YYYYKKKDDD G--------- ----KKAEKV VPPKKKKKVV LLNPDDDGGG LVVGGSSIFR YYYYKKKDDD G--------- ----KKAEKV VPPKKKKKVV LLDPDDDGGG FVVGGSNMIR FFFFKQQDDD G--------- ----SSSELA VKKLLKKKVV LLDPDDDGGG FVVGGTNMIR FFFFKQQDDD G--------- ----SSNEIV VEELLKKKVV LLDPDDDGGG YVVGGSNMIR FFFFKSSDDD D--------- ----TTSEIV VKKLLKKKVV LLDPDDDGGG FVVGGSNMIR FFFFKSSDDD E--------- ----TTSEVV VKKLLKKKVV LLDPDDDGGG YVVGGTNMVR FFFFKAADDD G--------- ----SSSEVA IKKLLKKKVV LLEPEEEAAA FVVGGGGIFR HHHHPEEEEE N--------- TT--TTATLV IPPKKKKKVV LLEPEEEAAA FVVGGGAIFR HHHHPEEKKK N--------- KK--VVTSLV IPPKKKKKVV ---------- ---------- ---------- ---------- ---------- ---------- LLNPNNNGGG YVVGGXXXXX XXXX------ ---------- ---------- -----QQQGG LLNPAAAGGG FVVGGNKVFH KKKKKSSDDD S--------- EEFFEEKVID GKKVVDDDTT ---------- ---------- ---------- ---------- ---------- ---------- LPGSNNNAAA FSSTTTQLWL YYYYEDDAAA G--------- ---------- WQQKKAAAVV LAGENNNCCC FTTSSTQLWL YYYYEGGEEE G--------- ---------- WQQKKAAAVV ILLKPKVVVP VIIIDILLLD DFFLLSSWGG GVRQDSNFKK VLLLLLTTTG GGKKKVGIIF VLLKDKVVVP VIIIDILLLD DFFVVSSWGG GLRQDTNHQQ RLLLLLAAAG GGRRRVGLLY LLLQGGVVVP VIIIDLLLLD DFFVVSSWGG GMRQDSDHNN VLLLLLAAAG GGSSSVGIIA LLLQGGVVVP VIIIDLMMMD DFFVVSSWGG GMRQDSDRKK KLLLLLAAAG GGSSSVGIIA LLLKGGCCCP VIIIDLLLLD DYYVVAAWGG GMHQDSDMNN VLLLLLTTTG GGKKKVGIIV VLLKGKVVVP VIIIDLMMMD DFFVVSSWGG GLLQDSDFEE KLLLLLTTTG GGKKKVGIIV ILLKPKVVVP VIIINLVVVD DFFVVSSWGG GLHQDSDFNN RLLLLLTTTG GGKKKVGIIV LLLKDGVVVP VIIINLLLLD DFFVVSSWGG GLRQDSDFNN RHHHHHTTTG GGSSSVGIIV KGGWMPMMMG IIIILLLLLD DFFFFSSWLL GIRQDSNQKK RLLLLLTTTG GGQQQIGSSI KGGWMPMMMG IIIILLLLLD DFFFFSSWLL GIRQDSNKKK RLLLLLTTTG GGQQQIGSSI KGGWMPMMMG IIIILLLLLD DFFFFSSWLL GLRQDSDQRR RLLLLLTTTG GGQQQLGSSI KGGWMPMMMG IIIILLLLLD DFFFFSSWLL GIRQDSDQRR RLLLLLTTTG GGQQQLGSSI KGGWLPMMMG IIIILLLLLD DFFFFSSWLL GLRQDSDQRR RLLLLLTTTG GGQQQLGSSI KGGWLPMMMG IIIILLLLLD DFFFFSSWLL GLRQDSDQRR RLLLLL---- ---------- KGGWLPMMMG I--------- ---------- ---------- ---------- ---------- KGGWLPMMMG IIIILLLLLD DFFFFSSWLL GLRQDSDQRR RLLLLLTTTG GGQQQLGSSI KGGWMPMMMG IIIILLLLLD DFFFFNNWLL GMRQDSDKRR RLLLLLVVVG GGQQQIGSSI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AKKFGVLLLN FAAAWIFFFS SLLFFLL--- ---------- ---------- ---------- EGGWAPMMMG IIIILILLLD DFFFFSSWLL GIRQDTDRNN KLLLLLVVVG GGQQQIGSSI EGGWPPMMMG IIIILILLLD DFFFFSSWLL GIRQDTDRNN KLLLLLVVVG GGQQQIGSSI QNNWIPMMMG IFFFLILLLD DFFFFVVWLL GIRQNEDKNN VLLLLLTTTG GGQQQLGLLI QNNWFPMMMG IFFFLILLLD DFFFFVVWLL GIRQNEDKNN KLLLLLTTTG GGQQQVGLLI ENNWIPMMMG IFFFLILLLD DFFFFVVWLL GIRQNEDKNN VLLLLLTTTG GGQQQIGLLL ENNWIPMMMG IFFFLILLLD DFFFFVVWLL GIRQNEDKNN VLLLLLTTTG GGQQQIGLLL RNNWIPMMMG IFFFVILLLD DYYLLVVWLL GIRQNEDAKK VLLLLLAAAG GGQQQVGLLL SGGWAPMMMA IIIILIMMMD DFFVVSSWLL GIRQDSDLKK KLLLLLNNNS SSQQQVGSSV ENNWAPMMMA IIIILIMMMD DFFVVSSWLL GIRQDSDKNN KLLLLLNNNS SSQQQVGSSI ---------- ---------- ---------- ---------- ---------- ---------- ENNGEEMMMG MIIILILLLD DYYFFSSWRR GVRQDSDANN RLLLLLTTTG GGQQQVGAAI GSSGVEMMMG IIIIIILLLD DFFVVNNWRR GVRQDTDENN KLLLLLTTTG GGQQQLGAAI ---------- ---------- ---------- ---------- ---------- ---------- ADDIGPDDDP PIIISIAAAD DTTIINNFMM GTRLDSDHKK FQQQQQIIIY YYEEEKRQQV ADDIGPKKKP PIIISINNND DRRVVNNFMM GTRLDSDHHH RQQQQQVVVY YYEEEKAQQV FHRRADH--- ---------- ---------G AAPQLLISRR RVYTTNLLLS DNPEEELGGW YHRREPH--- ---------- ---------G AAPQIIVSRR RVYTTNLLLS NNP---LGGW ARRRAPH--- ---------- ---------G GGPQVVISRR RVYTTNLLLS DDPDDDVAAA ARRRTPH--- ---------- ---------A GGPQVVISRR RVYTTNLLLS DDPDDDVGGV VKKKTPH--- ---------- ---------Y GGPQVVISKK RVYTTNLLLS DEPGGGRAAA VSRRATH--- ---------- --------AG GGPQVVISRR RVYTTNLLLG DPPEEEIGGW VRRRAGH--- ---------- --------AG GGPQVVISRR RVYTTNLLLR DEPDDDIGGW VRKKAAH--- ---------- ---------G GGPQVVVSRR RVYSSNLLLA DEPVVVIGGW IVRRGGSVE- -DQQEETTTQ QQPEPLVVVG GGPQIILSKK RLYTTTLLLS DK-PPPLRRE IVKKGGSVE- -DQQEETTTQ QQPEPLVVVG GGPQIILSKK RLYTTTLLLS DK-PPPLRRE IVKKGGPVE- -DQQEEKKKQ QQPEPLVVVG GGPQIILSKK RLYTTTLLLS DK-PPPLRRE IVKKDGPVD- -DQQEEDDDQ QQPEPLVVVG GGPQIILSKK RLYTTTLLLS DK-PPPLRRE IVKKGGPVE- -DQQEEKKKQ QQPEPLVVVG GGPQIILSKK RLYTTTLLLS DK-PPPLRRE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IVKKGGPVE- -DEEEEKKKQ QQPEPLVVVG GGPQIILSKK RLYTTTLLLS DK-PPPLRRE IVKKGGPVE- -DQQEEKKKQ QQPEPLVVVG GGPQIILSKK RIYTTTLLLS DK-PPPLRRE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ILRRGGPVE- -DKKDDEEEQ QQPDPVIIVG GGPQIILSKK RLYTTNLLLS DK-PPPMKKE IQRRGGPVE- -DKKEEEEEQ QQPDPVTTVG GGPQIILSKK RIYTTSLLLS DK-PPPLKKE IQKKGSPAG- -EDDGGTTTQ QQSDVPEEIG GGPQIILTKK RLYTTNLLLS DK-PPPLEEK IQKKGSPAK- -DDDGGTTTQ QQSDVPEEIG GGPQIILSKK RLYTTNLLLS DK-PPPLEEQ LQKKGSPAG- -EDDGGSSSQ QQFDVPQQIG GGPQIILSKK RLYTTNLLLS DR-PPPLDDK LQKKGSPAG- -EDDGGTTTQ QQFEVPQQIG GGPQIILSKK RLYTTNLLLS VV-PPPIEEK LQKKGSEYT- -EDDDDEEEQ QQYSVPQQVG GGPQIILSKK RIYTTNLLLS DEGQQQLKKK VHTTESNVE- -GEEKK---P PPIEALYYVG GGPQLLLSKK RLYTTTLLLK DD-PPPHKKS IHSSETTVE- -EDDHH---E EEIPALYYVG GGPQLLLSKK RLYSSTLLLK DD-PPPNRRS ---------- ---------- ---------G GGPAIILSKK RLYTTNFFFS DK-PPPVKKE IQRRDAPVN- -DPPEEKKKA AAPEPVFFLG GGPQLLLSRR RLYSSSLLLS DK-PPPMAAA ICSSDLPIKE EDKKEEKKKR RRPPARYYVG GGPQLLLSKK RLYSSSLLLS DK-PPPMSSQ ---------- ---------- ---------- ---------- ---------- ---------- VN-------- ---------- ---------- ----VVQSKK RVYSSSLLLA D------KKK VN-------- ---------- ---------- ----VVSSQQ RLYTTSLLLA D------KKK WMVVVVKKKL LLLNAANN-- --SGGEDDKK KFVDFGGEE- ------AHHQ QRDASSSYYY WMAAAAKKKV VVVNVVNN-- --EGGEEEKK KFVDFGGRR- ------AHHQ QRDASSSFFF AQVVVVLLLA AAAHAAGG-- --DGGTAADD DWVEFPPDDG ------YHHQ QRDCSSSFFF VEVVVVMMMA AAANVVGG-- --NGGEDDKK KFVSFPPDDG ------YHHQ QRDCSSSFFF AMVVVVMMMA AAANVVGG-- --NGGTDDKK KWVDFPPAAG ------YHHQ QRDCSSSFFF WMVVVVKKKL LLLDAAGG-- --NGGEDDPP PFLEWPPKKG ------HHHQ QRDCSSSYYY WMVVVVKKKV VVVDVVNN-- --DGGQDDPP PFVDFGGEE- ------QHHQ QRDASSSYYY WIAAAAKKKA AAAEAADD-- --GGGSDDPP PFTEVGGDDG ------LHHQ QRDSSSSYYY EGSSSSVVVM MMMLQQVVDD DTNGGKNNPP PLVDFGGKKE LLLLPPAHHE ERDCSIIWWW EGSSSSVVVM MMMLQQIIDD DTNGGKNNPP PLVDFGGKKE LLLLPPAHHE ERDCSIIWWW EGSSSSVVVM MMMLQQIIDD DTKGGKNNPP PLVDFGGKKE LLLLPPAHHE ERDCSIIWWW EGSSSSVVVM MMMLQQIIDD DTKGGTNNPP PLVDFGGKKE LLLLPPAHHE ERDCSIIWWW EGSSSSVVVM MMMLQQVVDD DTKGGKNNPP PLVDFGGKKE LLLLPPAHHE ERDCSIIWWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EGSSSSVVVM MMMLQQVVDD DTKGGKNNPP PLVDFGGKKE LLLLPPAHHE ERDCSIIWWW EGSSSSVVVM MMMLQQIIDD DTKGGKNNPP PLVDFGGKKE LLLLPPAHHE ERDCTIIWWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- EGSSSSVVVM MMMLQQIIDD DTKGGKNNPP PLVDFGGKKE GGGGPPVHHE ERDCSIIWWW EGAAAAVVVM MMMLQQIIDD DTKGGKNNPP PLVDFGGKKE DDDDPPVHHE ERDCTIIWWW KGSSSSHHHI IIILQQIIDD DTKGGKNNPP PFVDFGGAAE DDDDPPAHHE ERDCTIIWWW QGSSSSHHHI IIILQQIIDD DTNGGKNNPP PFVDFGGAAE DDDDPPSHHE ERDCTIIWWW KGSSSSHHHI IIIIQQIIDD DTKGGSNNPP PFVDFGGDDE EEEEPPAHHE ERDCTIIWWW KGSSSSHHHI IIIIQQIIDD DTKGGTNNPP PFVDFGGDDE DDDDPPSHHE ERDCTIIWWW KGSSSSHHHM MMMLQQIIDD DTKGGSNNPP PFVDFGGAAE EEEEPPSHHE ERDCTIIWWW SGAAAATTTM MMMVQQVVDD DPSKKENNRR RLIDFGGKKI GGGGPPYHHE ERDCTIIWWW SGAAAATTTM MMMLQQIIDD DPTHHVNNKK KLIDFGGKKV GGGGPPYHHE ERDCTIIWWW EGSSSSVVVM MMMLQQIIDD DTKGGTNNKK KLVDFGGKKE NNNNPPCHHD DRDSTIILLL AGGGGGTTTI IIIVQQLLDD DVNGGKNNEE ELVDFGGGGE YYYYPPGHHE ER-------- QGGGGGHHHI IIIVLLIIDD DTNGGSNNEE ELVDFAANNE YYYYPPSHHE ERDCTIIWWW ---------- ---------- ---------- ---------- ---------- ---------- KGKKKKDDDD DDDAQQYYAA AYWGGEVVEE EAVDFYYEEL LLLL---HHI IRALY----- KGKKKKDDDD DDDEQQFFLL LYWGGEKKEE EAIDFYYAAE LLLL---HHQ QRALYPPAAA YYP---- YYP---- YYPS--- YYPS--- YYPS--- YYP---- FFP---- YYPS--- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- AAND--- ------- ------- DDGNQVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNSSAAKKSS SEEATPAVVV TTTAAARAAA AMQSTQLLLL TGVIAYQEEA AAAWSSSSAI gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- -----MAGGR RSSALLPPPL gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IVLLASSSRS SSSEKGGGRK TVLVVEISSA VQVPSSAAAV LLPPGKHHGG AAAVVIAAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AARAEEGG AFFTTQSSSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLGGEEPPGG HTTAAPWWWW ---------- ---------- ---------- ---------- SSQQCLGGFF DQQTTTEEEE ---------- ---------- ---------- ---------- ---------- ---------- LNRRTPPTHP PPPNLAAAPA SHVPPLTRRV RRTNVVPPRL AARRSLVVLL QHHIIEGGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----ATTTT ---------- ---------- ---------- ---------- ---------- -----GTTTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMKKREFFGG ---------- ---------- ---------- ---------- ---------- MMKKFIVVSS GPPSSHFFFF ---------- -----IIVFR DDPTFYYSSS PPPMMAMMMK KAPDDLLAYY YVVCTGGGTT ---------- -----MMALP DDPTFYYTTT PPPDDAMMMR RAPDDIIAYY YVVAVGGGTT ---------- -------MMP DDPTFHHSSS PPPLLAMMMQ QAAEEFFAYY YTTLPDDDFF ---------- -------MMP DDPTFHHSSS PPPLLAMMME EAANNFFAYY YTTLPDDDFF ---------- -------MLP DDPTFYYSSS AAALLAMMME EGVKKLLAFF FTTMPDDDAA ---------- -----MMAWP DDPSFYYSSS PPPLLAAAAK KAPTTIIAYY YVVMPEEERR ---------- -----MMVWP DDPTFYYSSS PPPMMAVVVK KAAKKLLAYY YVVRPMMMAA ---------- -----MMAWP DDPTFYYSSS PPPMMAMMMQ QARRRLLGYY YVVLPGGGRR ---------- ----MCCT-C GGPGYPPPPP LLLAAMKKK- -GREEIIVYY YLLCRNNNTT ---------- ---------- ---------- ------MMM- -GREEIIVYY YLLCRNNNTT PPPAAARRPP PG-AHCCG-C GGPGYPPPPP LLLAAMKKK- -GREEIIVYY YLLCGNNNTT ---------- ---------- ---------- -----MKKK- -GREEIIIYY YLLCRNNNTT ---------- ----MCCG-C GGPGYSSPPP LLLAAMKKK- -GREEIIVYY YLLCRNNNTT VVVAAAQQPP PIASTCCG-C GGPGYSSPPP LLLAAMKKK- -GREEIIVYY YLLCRNNNTT ---------- ----MCCG-C GGPGYSSPPP LLLAAMKKK- -G-------- ---------- ---------- ----MCCG-C GGPGYSSPPP LLLAAMKKK- -GREEIIVYY YLLCRNNNTT FFFLLLSSWW WQEDTCCG-C GGPGYPPPPP QQQAAMKKK- -GREEIIVYY YLLCRNNNTT LLLHHHTTLL LVFTSCCG-C GGPGYSSPPP LLLAAMKKK- -GREEIIVYY YLLCRNNNTT ---------- ----MCCG-C GGPGYSSPPP LLLAAMKKK- -GREEIIVYY YLLCRNNNTT AAAAAAAAAA AAAANCCCTK GGPGYAAPPP LLLAAMEEEK KGRKKLLVYY YVVCNGGGTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----CCG-C GGPGYKKPPP LLLAAMKKK- -GREEIIVYY YLLCRSSSTT VVVLLLDDVV VNEKKNNGCS GGPGYAAPPP IIISSMSSS- -GRSSLLIYY YVVAAGGGTT VVVLLLQQVV VSEKVQQGCS GGPGYAAPPP LLLAAMSSS- -GRTTLLIYY YVVAAGGGTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----RRMQG GGPGYAAPPP LLLAAMSSS- -GSKKLLIYY YVVATGGGTT --------AA AAAANCCCGT GGPGYAAPPP LLLAAMEEEK KGRKKLLLYY YVVCNGGGTT --------MM MSPNCCCH-- GGPGYAAPPP AAAAAIKKK- -GREEVVLFF FVVA----NN --------MM MP--CCCH-- GGPGYAAPPP AAAAAIKKK- -GREEVVLFF FVVA----HH ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----EESCC GGPGYAAPPP LLLAAVRRRN NGVKKLLLYY YVVCPNNNLL ---------- ---------- ---------- -----MRRRS SGRKKLLLYY YTTTPNNNLL ---------- ---------- MMPGLII--- ---IILIIIS SLDFFLLYFF FSSWGDDDII --------AA AG-ALLLPRF AADETCCSSS PPPMMPKKKI ITQEEFFVYY YVVTVEEEGG AAALLLRRSS SGLALAAPGR AADETCCSSS PPPMMKKKKI ITQDDYYVYY YVVTAEEEGG GIRFFIINPP KSYSKVHHKK KELYYDEFGG GGNACSSSSA LLC---PPKK KPPPNERRRR GVAFFLLDPP KSYGKIYYKK KDLYYDEFGG GGNACSSSSA YYC---PPKK KPPPFERRRR S-RAALLKPP GSYGKVHHTT TTMNNDEFGG GGNACSSSSS LLS---PPHH HAAAFERRRR S-KAALLKPP GSYGQVHHTT TTMNNDEFGG GGNACSSSSA LLS---PPHH HAAAFERRRR S-KGGLLDPP TSFGQVHHQQ QIMNNDEFGG GGNACSSSSA LLS---PPHH HAAAFERRRR K-QAAIIDPP ASYASVGGQQ QAMHHDEFGG GGNACSSSSC LLC---PPHH HPPPHERRRR NGKAAMMDSS QSFGQVGGVV VDMYYGEFGG GGNACSSSSM LLC---PPHH HPPPHERRRR E-RAALLDPP DSYAQVGGRR REMNNDEFGG GGNACSSSSA LLC---PPHH HPPPHERRRR GTAYYLLDPP KSYSQIHHRR RPMYYDESGG GGNTCSSSSC --------DD DSSSTSRRRR GIAYYLLDPP KSYSQIHHRR RPMHHDESGG GGNTCSSSSC --------DD DSSSTSRRRR GIAYYLLDPP KSYCQIHHRR RPMNNDESGG GGNACSSSSC --------DD DSSSTSRRRR GIAYYLLDPP KSYCQIHHRR RPMHHDESGG GGNTCSSSSC --------DD DIIITARRRR GTAYYLLDPP KSYCQIHHRR RPMNNDESGG GGNTCSSSSC --------DD DSSSTSRRRR GTAYYLLDPP KSYCQIEE-- ---------- ---------- ---------- ---------- -TAYYLLDPP KSYCQIHHRR RPMNNDESGG GGNTCSSSSC --------DD DSSSTSRRRR GTAYYLLDPP KSYCQIHHRR RPMNNDESGG GGNTCSSSSC --------DD DSSSTSRRRR GTAYYLLDPP KSYSQIHHRR RPMYYDESGG GGNTCSSSSC --------DD DSSSTSRRRR GTAYYLLDPP KSYCQIHHRR RPMNNDESGG GGNTCSSSSC --------DD DSSSTSRRRR GTAYYLLDPP KSYCQIHHRR RPMNNDESGG GGNTCSSSSC --------DD DSSSTSRRRR GIKYYLLDPP SSYSQIHHRR RPVHHDKSGG GGNSCSSSSC --------DD DPPPSKRRRR ---------- ---------- --MNNDESGG GGNTCSSSSC --------DD DAAASVRRRR GIKYYLLDPP KSYSQIHHRR RPMNNDESGG GGNTCSSSSC --------DD DSSSSVRRRR GIKYYLLDPP SSYSKIHHRR RPVYYDETGG GGNSCSSSSC --------DD DPPPSERRRR GIKYYLLDPP NSYSKIHHRR RPVYYDETGG GGNSCSSSSC --------DD DPPPSQRRRR ---------- ---------- --MFFDESGG GGNSCSSSSC --------DD DAAASDRRRR GIKYYLLDPP SSYSSIHHRR RPMFFDESGG GGNSCSSSSC --------DD DAAASDRRRR GIKYYLLDPP NSYSQIHHRR RPVHHDESGG GGNACSSSSC --------DD DPPPSSRRRR AAGAAIINPP ESFCQISSRR RDVHHDETGG GGNACSSSSC --------KK KPPPTKRRRR ARGAAIINPP ESFCQISSRR RDVNNDETGG GGNACSSSSC --------KK KPPPTKRRRR ---------- ---------- ---------- ---------- ---------- ---------- DEHYYLLDPP ASYCQIHHRR RYTSSNESGG GGNTCSSSSC HHFVVVPPKK KEEEVTRRRR DEHYYLLDPP ESYCQVHHRR RFTRRDESGG GGNACSSSSC YYYVVVDDKK KTTTVKRRRR RQDDDRRVGG QVGGSLKKDD DPVVVDKSQQ QQTPRIIIIK --------KK KRRRVGGGGG MGEKKLLRPP GSRGQINNSS SSVGGNEGGG GGSA------ ---------- -----DRRRR VGEKKLLNPP KSYGKVNNTT TSVGGNESDD DDTD------ ---------- -----DRRRR RIVGLLSSII YITPPPKKII VVIIPPPEEK KKKVVSLHHC GPDAIYYILL LLLEE--EGG RIVALLSSII YVTPPPAAAA IIVVPPPVVV VGGRRTYHHC GPDAIYYILL LLLPP--DGG RIIGLLSSII YITPPARRHH IIIIPPPEEL LAAKKSPHHC GPEGIYYVLL LLLAAKKDGG RIIGLLSSII YITPPAKKHH IIIIPPPEEF FKKKKSPHHC GPDGIYYVLL LLLGGKKDGG RIIGIISSII YVV--AKKHH IIIIPPPEEF FAAKKSPHHC GPEGIYYVLL LLLGGEEDGG RVVGLLSSII YLTPPPFFAA VVIIPPPTTA AEERRSPHHC GPGGIYYVLL LLLAA--EGG RVVDIISSII TLTPPPKKVV VVIIPPPEEA AEERRAPHHC GPDGIYYILL LLLPP--EGG RIVGIISSII HVTPPPRRVV VVIIPPPEEH HRRRRSPHHC GPDGVYYVLL LLLPP--EGG NILGLLSSII YVVSSPKKHH VVIIAAAEEQ QAAKKSTHHC LASGEVVMTT TTTDD--LQQ DILSIISSII YVVSSPKKHH VVIIPPPEEH HAAKKGLHHC LASGEVVMSS SSSDD--PQQ TMLCLLSSII YVVSSPKKHH VVIIAAADDH HAAKKGVHHC LASGEVVMTT TTTDD--SKK TVLALLSSII YVVTTPKKHH VVIIPPPDDH HTTKKGFHHC LPSGEVVMTT TTTDD--PEE TVLSLLSSII YVVSSPKKHH VVIIPPPDDH HAAKKALHHC LASGEVVMSS SSSDD--VKK ---------- ---------- ----PPPDDH HAAKKALHHC LASGEVVMSS SSSDD--VKK TVLSLLSSII YVVSSPKKHH VVIIPPPDDH HAAKKALHHC LASGEVVMSS SSSDD--VKK TVLSLLSSII YVVSSPKKHH VVIIPPPDDH HAAKKALHHC LASGEVVMSS SSSDD--VKK NVLSFFSSII YVVTTPKKHH VVIIAAADDH HEEKKGPHHC LPTGEVVMTT TTTDD--PKK TVLSLL---- ---------- ---------- ---------- ---------- ---------- TVLSLLSSII YVVSSPKKHH VVIIPPPDDH HAAKKALHHC LASGEVVMSS SSSDD--VKK RILSLLGGVV YVTTTPSSHH VVVVSSSDDA AEENNGPHHC LASGDIIMCC CCCDD--KEE NILCLLSSII YVVTTPRRHH TTVVPPPEEF FWWKKALHHC LGCGEIIMSS SSSDD--PYY NILCLLSSII YVVSSPRRHH TTVVPPPEEF FWWKKAPHHC LGCGEIIMSS SSSDD--PCC RIASLLGGII YITTTPSSHH VVVVPPPDDI IQQKKAPHHC LASGELLMCC CCCDD--KDD RIVGIIGGVV YITTTPSSHH VVVVPPPDDS STTKKAPHHC LASGEIIMCC CCCDD--KDD RVLSLLGGII YITEEPSSYY YYVVPPPEEA AEEKKAPHHC LASGEIILCC CCCDD--EEE RVLSLLGGII YITEEPSSYY YYVVPPPEEA ADDKKAPHHC RT-GEIILCC CCCDD--EEE RILSLLGGVV YVTKKPAAHH VVVVAAADDA AEEKKGPHHC LASGEIIMCC CCCDD--KEE SIVCLLDDII YIVNNIYYEE TTIIPPPKKH HSSLLSPHHC LADGNIIMTT TTTEE--ANN SIVCLLDDII YIVNNIYYQQ TTIIPPPKKH HAALLSPHHC LADGNIIMTT TTTEE--ADD -VPKLLGGEE GVVGG----- ---------- ---------- ---------- ---------- DVLCLLDDII FITTTPKKAA VVIIGGGDDL LKKGGTPHHC LPNGNIIMII IIIDD--AEE DVLSLLDDII YLVTTPEEVV TTIIGGGDDL LKKSSTPHHC LANGNIIMVV VVVDD--AEE PLQSLLKKLL YTSYYKQQYY -------DDI IKKFFASHDY QPNTALLKGG GGGEE--SLL RWTGLLNNII FFVSSPKKHH TTIITTTFFK KDDSSVPHFA LPGSMMMILL LLLDD--DDD RWAGLLSSII FFVSSPVVSS TTIIDDDFFE EKKSSVPHYA LPGRMLLILL LLLNN--KDD -GGLLHHHFF ELLWEEEIID RGGGQQYY-- ---------- LLADWWWNLP PLLVSSEEEW RGGLLHHHFF EIIWEEEVVY RGGGQQYY-- ---------- FFADWWWNLP PMMITSEEEW TGGMMCCCFF DLLWEEEIID RGGGQQDD-- ---------- KKHDWWWNLP PMMVSSEEEW TGGMMCCCFF ELLWEEEIID RGGGQQTT-- ---------- LLHDWWWNLP PMMVTSEEEW TGGLLCCCFF ELLYEEEMMD RGGGQQTT-- ---------- KKHDWWWNLP PMMVSSEEEW -GGLLAAAFF ELLWEEEVVE RGGGQQYY-- ---------- FFADWWWHLG GLLVTSEEEW -GGLLHHHLL ELLWEEEIID RGGGQQYY-- ---------- LLHDWWWHLG GLLLTSEEEW -GGMMHHHFF DLLWEEEVVE RGGGQQQQ-- ---------- LLADWWWHLG GMMVTSEEEW GGGLLGGGFF EKKWEEEKKP GGGGSSPP-- ---------- MMGDWWYQPR RMMVSTEEEW GGGLLGGGFF EKKWEEEKKP GGGGAAPP-- ---------- MMGDWWYQPR RMMVSTEEEW GGGLLGGGFF EKKWEEEQQP GGGGAAPP-- ---------- MMGDWWYQPR RMMISTEEEW GGGLLGGGFF EKKWEEEQQP GGGGAAPP-- ---------- LLGDWWYQPR RMMISTEEEW GGGLLGGGFF EKKWEEERRP GGGGAAPP-- ---------- SSGDWWYQPR RMMISTEEEW GGGLLGGGFF EKKWEEERRP GGGGAAPP-- ---------- LLGDWWYQPR RMMISTEEEW GGGLLGGGFF EKKWEEERRP GGGGAAPP-- ---------- LLGDWWYQPR RMMISTEEEW GGGLLGGGFF EKKWEEERRP GGGGAAPP-- ---------- LLGDWWYQPR RMMISTEEEW GGGLLGGGFF EKKWEEERRP GGGGAAPP-- ---------- MMGDWWYQPR RMMISTEEEW ---------- ---------- ---------- ---------- ---------- ---------- GGGLLPPPLL ESS------- ---------- ---------- ---------- -----AIIIS GAALLDDDFF NKKGSSSNNR LFFFIISS-- ---------- KKETLLYENA AFFWSWIIIQ GGGLLGGGFF EKKWEEEAAE GEEEAAPP-- ---------- FFGDWWYQPR RMMISTEEEW GGGLLGGGFF EKKWEEEVVE GEEEAAQQ-- ---------- FFGDWWYQPR RMMISTEEEW GAALLDDDFF NKKWEEEKKP GHHHPPLL-- ---------- FFGDWWYQPR RMMISTSSSW GAALLDDDFF NKKWEEEKKP GHHHPPLL-- ---------- FFGDWWYQPR RMMISTSSSW GAALLDDDFF NKKWEEEKKP GHHHPPLL-- ---------- FFGDWWYQPR RMMISTSSSW GAALLDDDFF NKKWEEEKKP DIIIPPLL-- ---------- YYGHWWYQPR RMMISTSSSW GAALLDDDFF NKKWEEEKKP GHHHPPLL-- ---------- FFGDWWYQPR RMMISSSSSW GPPLLGGGFF EKKWPPPAAD EKKKVVPP-- ---------- FFNDWWYQPR RMMISTEEEW GPPLLGGGFF EKKWPPPAAD GKKKVVPP-- ---------- FFNDWWYQPR RMMISTEEEW ---------- ---------- ---------- ---------- ---------- ----SILLLR GAAEEDDDFF EVVWSSSRRG DRRRAALL-- ---------- CCGDWWYQPH HMMVASEEEW GAALLDDDFF NIIWTTTKKG DKKKAALL-- ---------- CCGDWWYQPY YMMVSSEEEW SPPTTKKKNN GSSGEEEAAS QFFFEEII-- ---------- LLQSHHNNG- -SSESDRRRP HGGYYDDDEE YAAWMMMPPT ADDDMMQQGG VVGGGGAAGG YYGDRRALIR RMMLTSSSSF HGGYYNNNEE YAAWIIIPPT DGGGLLRRGG IIGGGGKAGG YYDDRRALPR RLLVTSSSSF PP---IIEEG GGLLKD-YRR IIHFFWDDLL RKRKKRRHSS TENNRMA--- ------EERD PP---FFEEG GGFLKEGYKK LLHVVWDDLL AKRRRHHYAA DEHHRMV--- ------EERD PP---FFEEG GGILLANYRR LLHFFWDDLL RARRRNNQTT DQHHQMA--- ------EERD PP---FFEEG GGILLSNYRR LLHFFWDDLL RARRRNNQTT DNHHQMA--- ------EERD PP---FFEEG GGILLSNYKK IIHFFWKKLL RDRKKNNQTT DNHHQMA--- ------EERD PP---VVEEG GGLLLGAYRR LLHFFWDDLL TRRRRHHQEE DEHHQLV--- ------EERD PP---VVEEG GGVLLAGYRR LLHVVWDDLL YRRRRHHQTT DEYYQMA--- ------EERD PP---IIEEG GGLLLNKYRR LLHIIWDDLL RRRRRHHQAA DEHHQMV--- ------EERD PP---FFKKG GGNEA-GYRR IIFVVWDDWW QRHEEIIQTT Q-DDGLI--- -----LEERD PP---FFKKG GGNEA-GYHH IIHVVWDDWW QRHEEIIQTT Q-DDGLI--- -----LEERD PP---FFRRG GGNEA-GYHH LLHVVWDDWW QRHEEIIQTT T-DDGLI--- -----LEERN PP---LLRRG GGNKA-GYHH LLYVVWDDWW QRREEIIQTT P-DDGLI--- -----LEERN PP---LLRRG GGNEA-GYHH LLYVVWDDWW QHHEEIIQTT S-DDGLI--- -----LEERN PP---LLRRG GGNEA-GYHH LLYVVWDDWW QRHEEIIQTT S-DDGLI--- -----LEERN PP---LLRRG GGNEA-GYHH LLYVVWDDWW QRHEEIIQTT S-DDGLI--- -----LEERN PP---LLRRG GGNEA-GYHH LLYVVWDDWW QRHEEIIQTT S-DDGLI--- -----LEERN PP---VVQQG GGNEA-GYHH LLHVVWDDWW QRHEEIIQTT L-DDGHI--- -----LEERD ---------- ---------- ---------- ---------- ---------- ---------- SS---RRLLG GGRSA-SVII TT-------- ---------- ---------- ---------- SS---YYTTG GGETA-SVII SSCLLDNNYY IMRVVIIESS P-DDQAGNNN NPPIILCCRW PP---FFAAG GGKQA-GYSS LLNVVWDDWW TEHRRRRQTT D-DDGLI--- -----LEERD PP---FFAAG GGKQA-GYSS LLNVVWDDWW TEHRRLLQTT D-DDGLI--- -----LEERN PP---FFTTG GGDAD-GYHH LLTCCIQQLL ARGEELLQTT D-TTGLL--- -----LEERD PP---FFLLG GGNAD-GYHH LLHVVYSSWW PGGEEIIQTT D-KKGLL--- -----LEERD PP---FFSSG GGDAD-GYHH LLHVVYSSWW PGGEEMMQLL D-TTGLL--- -----LEERD PP---FFSSG GGNAD-GYHH LLHVVYSSWW PGGEEIIQLL D-TTGLL--- -----LEERD PP---FFRRG GGDQD-GYHH LLHVVYDDWW PGGEELLQTT D-TTGLL--- -----LEERD PP---IIKKG GGNGE-GYSS VVHIIFEEWW DSKKKYYQTT DPLLGAL--- -----LEERE PP---IIKKG GGNPE-GYSS VVHIIFEEWW DTKKKHHQTT DPRRGAL--- -----LEERE PP---VVCCD DDEPE-PVCC KKRVVY---- ---------- ---------- ---------- PP---FFRRG GGHDDRTYRR LLNFFYRRWW QEREELLQTT D-DDGLT--- -----LEERN PP---WWRRG GGKEDMSYRR LLNFFYKKWW STQTTLLQTT D-DDGIT--- -----LEERN PP---AAFFS SSEKTGPKHH VVAEEVLL-- ---------- ---------- ---------- WWNNYMMDDG GGMEAMKFTT IIVQQWDDLL HTRQQPPKVV NAPP------ -----LEERG WWNNYMMDDG GGMEAMKFTT VVVTTWDDLL HTKQQPPKVV DAPP------ -----LEERG DPTTMMMGGG FIINVSLKKL LSSIILWFYY EEDGGEKIEP AEEPPLEEEE GG-NNLPPEE DPTTMMMGGG FVVNVNTKKL LSSIILWFYY EEDGGERIDE AQQPPFEEEE GG-PPLPPPP DPVVYYYGGG FVVGVDTTTL LEGIITWWRR EEGGGKKATP AEEPPATTTT AADEELPPPP DPVVYYYGGG FVVGVDTTTL LEAIITWWRR EEGGGEKATP PEEPPAPPPP KKEKKLPPPP DPSSYYYGGG FCCGVDTTTL LQGIITWWQQ DDDGGKKITD PVVPPADDDD AADDDLPPDD DPTTYYYGGG FVVNVSLKKL LSSIITWYRR DDKDDRKIEP AEEAAADDDD PPDQQLPPPP DPTTYYYGGG FMMNVSLKKL LSAIILWYRR DDNGGKKIDP AEEPPASSSS EEDQQLPPPP DPAAYYYGGG FVVGVSLEEL LSAVVLWHRR QQNGGRKIEP AEEPPAEEEE PPDQQLPPPP DPSSQQQGGG FVVGASSNNQ QRFKKEEG-- -------TWV EKKVVIQQQQ VVPSSKKKVV DPDDQQQGGG FVVGASSNNQ QRFKKEGG-- -------TWV EKKVVIQQQQ VVPSSKKKVV NPDDQQQGGG FVVGASSTTQ QRFKKQGG-- -------TWV EKKVVIQQQQ VVPPPKKKVV NPDDQQQGGG FVVGASSTTQ QRFKKEDG-- -------TWA QKKVVIQQQQ VVPPPKKKVV NPDDQQQGGG FVVGASSTTQ QRFKKEGG-- -------TWV EKKVVIQQQQ VVPPPKKKVV NPDDQQQGGG FVVGASSTTQ QRFKKEGG-- -------TWV EKKVVIQQQQ VVPPPKKKVV NPDDQQQGGG FVVGASSTTQ QRFKKEGG-- -------TWV EKKVVIQQQQ VVPPPKKKVV NPDDQQQGGG FVVGASSTTQ QRFKKEGG-- -------TWV EKKVVIQQQQ VVPPPKKKVV DPAAQQQGGG FVVGASSTTQ QRFKKEGG-- -------TWV EKKVVIEEEE VVPPPKKKVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WKNNQQQDDD YDDVESFSSR RGGDDDAY-- -------AVL KRRKKLDDDD LLYYYAVVVV DPDDQQQGGG LVVGASSTTF FRFKKKDG-- -------KWA EKKVVIKKKK VVPSSKKKVV NPDDQQQGGG LVVGASSSSF FRFKKKDG-- -------KWA EKKVVIQQQQ VVPSSKKKVV DPAATTTGGG FVVGASSNNI IRFKKQDG-- -------SWH ELLAAIPPPP VVKPPLKKVV DPAATTTGGG FVVGATSNNI IRFKKQDG-- -------SWH EIIVVISSSS VVEPPLKKVV DPSSTTTGGG YVVGASSNNI IRFKKSDD-- -------TWY EIIVVISSSS VVKPPLKKVV DPSSTTTGGG FVVGASSNNI IRFKKSDE-- -------TWH EVVVVISSSS VVKPPLKKVV DPSSTTTGGG YVVGATSNNV VRFKKADG-- -------SWH EVVAAISSSS IIKPPLKKVV EPTTHHHAAA FVVGAGSGGF FRIPPEENSS ------TTHA TLLVVAFFFF IIPSSKKKVV EPTTHHHAAA FVVGAGSAAF FRIPPEKNPP ------KVQA SLLVVATTTT IIPSSKKKVV ---------- ---------- ---------- ---------- ---------- ---------- NPRRQQQGGG YVVGAXXXXX XXX------- ---------- ---------- ------QQGG NPKKEEEGGG FVVGANAKKF FHFKKSDSDD ------EEAK VIIDDIPPPP GGKLLVDDTT ---------- ---------- ---------- ---------- ---------- ---------- GSNNYYYAAA FSSTATSQQW WLIEEDAG-- ---------- ------EEEE WWQAAKAAVV GEAAYYYCCC FTTSATSQQW WLIEEGEG-- ---------- ------EEEE WWQAAKAAVV LLKPPPFKKV PPLTDDILFL SLLLWGGGII GGEERQQQYD IINNPPPFFV LGGKLLGGII LLKDDDFKKV PPLTDDILFV SLLLWGGGLL GGEERQQQYD IINNPPPHHR LGGRIIGGLL LLQGGGFGGV PPLTDDILFV SCCCWGGGTT GGEERQQQYD VVDDPPPHHV LGGSIIGGII LLQGGGFGGV PPLTDDIMFV SCCCWGGGTT GGEERQQQYD VVDDPPPRRK LGGSIIGGII LLKGGGFGGC PPLTDDILYV ACCCWGGGLL GGEEHQQQYD VVDDPPPMMV LGGKIIGGII LLKGGGFKKV PPLTDDIMFV SCCCWGGGTT GGDDLQQQYD VVDDPPPFFK LGGKIIGGII LLKPPPFKKV PPLTDDIVFV SCCCWGGGTT GGEEHQQQYD VVDDPPPFFR LGGKIIGGII LLKDDDFGGV PPLTDDILFV SCCCWGGGTT GGEERQQQYD VVDDPPPFFR HGGSLLGGII GGWMMMLPPM PGLTDDILFF SNNNWLLLHH GGDDRQQQYD IINNPPPQQR LGGQLLGGSS GGWMMMLPPM PGLTDDILFF SNNNWLLLHH GGDDRQQQYD IINNPPPKKR LGGQLLGGSS GGWMMMLPPM PGLTDDILFF SNNNWLLLHH GGDDRQQQYD IIDDPPPQQR LGGQLLGGSS GGWMMMLPPM PGLTDDILFF SNNNWLLLHH GGDDRQQQYD VVDDPPPQQR LGGQLLGGSS GGWLLLLPPM PGLTDDILFF SNNNWLLLHH GGDDRQQQYD IIDDPPPQQR LGGQLLGGSS GGWLLLLPPM PGLTDDILFF SNNNWLLLHH GGDDRQQQYD IIDDPPPQQR L--------- GGWLLLLPPM PGLT------ ---------- ---------- ---------- ---------- GGWLLLLPPM PGLTDDILFF SNNNWLLLHH GGDDRQQQYD IIDDPPPQQR LGGQLLGGSS GGWMMMLPPM PGLTDDILFF NNNNWLLLHH GGDDRQQQYD IIDDPPPKKR LGGQLLGGSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKFGGGVVVL SNEPPPAFLF LSSS------ ---------- ---------- ---------- GGWAAALPPM PGLTDDILFF SNNNWLLLHH GGDDRQQQYD IIDDPPPRRK LGGQLLGGSS GGWPPPMPPM PGLTDDILFF SNNNWLLLHH GGDDRQQQYD IIDDTTTRRK LGGQLLGGSS NNWIIILPPM PGLTDDFLFF VNNNWLLLHH GGDDRQQQYN IIDDLLLKKV LGGQVVGGLL NNWFFFLPPM PGLTDDFLFF VNNNWLLLHH GGDDRQQQYN IIDDVVVKKK LGGQAAGGLL NNWIIILPPM PGLTDDFLFF VNNNWLLLHH GGDDRQQQYN IIDDPPPKKV LGGQVVGGLL NNWIIILPPM PGLTDDFLFF VNNNWLLLHH GGDDRQQQYN IIDDPPPKKV LGGQVVGGLL NNWIIILPPM PGLTDDFLYL VNNNWLLLHH GGDDRQQQYN IIDDPPPAAV LGGQAAGGLL GGWAAALPPM PALTDDIMFV SCCCWLLLHH GGDDRQQQYD IIDDPPPLLK LSSQIIGGSS NNWAAALPPM PALTDDIMFV SCCCWLLLHH GGDDRQQQYD IIDDPPPKKK LSSQIIGGSS ---------- ---------- ---------- ---------- ---------- ---------- NNGEEEIEEM GGMTDDILYF SNNNWRRRHH GGDDRQQQYD IIDDRRRAAR LGGQLLGGAA SSGVVVAEEM GGMSDDILFV NCCCWRRRHH GGDDRQQQYD IIDDPPPEEK LGGQLLGGAA ---------- ---------- ---------- ---------- ---------- ---------- DDIGGGNPPD IPLVDDIATI NSSSFMMMDD GGKKRLLLFD IIDDPPPHHF QYYEIIRRQQ DDIGGGEPPK VPLVDDINRV NTTTFMMMDD GGKKRLLLFD IIDDPPPHHR QYYEIIAAQQ FFRRAADHPP ---------- ---------A GHKGMLEEII ISSRRRDGRV VVYVTTSLLL YYRREEPHPP ---------- ---------S GAEGMISSVV VSSRRRDGRV VVYITTSLLL AARRAAPHPP ---------- ---------N GRTGMVEEII ISSRRRDGRV VVYWTTSLLL AARRTTPHPP ---------- ---------N GKAAMVEEII ISSRRRDGRV VVYWTTSLLL VVKKTTPHPP ---------- ---------N GKTYMVEEII ISSRRRDGKV VVYWTTSLLL VVRRAATHPP ---------- ---------K NGAGMVEEII ISSRRRDGRV VVYFTTSLLL VVRRAAGHPP ---------- ---------T SAEGMVEEII ISSRRRDGRV VVYFTTSLLL VVKKAAAHPP ---------- ---------A SGPGMVEEVV VSSRRRDGRV VVYFSSSLLL IIRRGGGSVV VL--DDQQLL LTQEEPLLVK GKRGMIQQLL LSSLLLDGKL LLYATTSLLL IIKKGGGSVV VL--DDQQLL LTQEEPLLVK GKRGMIQQLL LSSLLLDGKL LLYVTTSLLL IIKKGGGPVV VL--DDQQLL LKQEEPLLVK GKKGMIQQLL LSSLLLDGKL LLYVTTSLLL IIKKDDGPVV VL--DDQQLL LDQEEPLLVK GKQGMIQQLL LSSLLLDGKL LLYVTTSLLL IIKKGGGPVV VL--DDQQLL LKQEEPLLVK GKRGMIQQLL LSSLLLDGKL LLYITTSLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIKKGGGPVV VL--DDEELL LKQEEPLLVK GKRGMIQQLL LSSLLLDGKL LLYITTSLLL IIKKGGGPVV VL--DDQQLL LKQEEPLLVK GKRGMIQQLL LSSLLLDGKI IIYVTTSLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIRRGGGPVV VL--DDKKLL LEQDDPVVIK GKKGMIQQLL LSSLLLDGKL LLYVTTSLLL IIRRGGGPVV VL--DDKKLL LEQDDPVVTK GKIGMIQQLL LSSLLLDGKI IIYVTTSLLL IIKKGGSPVV AI--EEDDKK KTQDDVPPEQ GQKGMIQQLL LTTLLLDGKL LLYVTTSLLL IIKKGGSPVV AV--DDDDEE ETQDDVPPEQ GKKGMIQQLL LSSLLLDGKL LLYVTTSLLL LLKKGGSPVV AV--EEDDNN NSQDDVPPQK GKSGMIQQLL LSSLLLDGKL LLYATTSLLL LLKKGGSPVV AV--EEDDNN NTQEEVPPQK GKSGMIQQLL LSSLLLDGKL LLYATTSLLL LLKKGGSEVV YV--EEDDKK KEQSSVPPQK GHRGMIQQLL LSSLLLDGKI IIYVTTSLLL VVTTEESNVV VL--GGEE-- --PEEALLYK GRKGMLQQLL LSSLLLDGKL LLYVTTSLLL IISSEETTVV VL--EEDDDD D-EPPALLYK GRQGMLQQLL LSSLLLDGKL LLYVSSSLLL ---------- ---------- ---------- ---GKIQQLL LSSVVVDGKL LLYVTTSFFF IIRRDDAPRR VL--DDPPLL LKAEEPVVFK GRRGMLQQLL LSSLLLDGRL LLYVSSSLLL IISSDDLPNN IVEEDDKKLL LKRPPARRYK GRRGMLQQLL LSSLLLDGKL LLYVSSSLLL ---------- ---------- ---------- ---------- ---------- ---------- VV-------- ---------- ---------- ----MVSSQQ QSSWWWDGKV VVYFSSSLLL VV-------- ---------- ---------- ----MVSSSS SSSWWWDGQL LLYYTTSLLL TNFLLKMVKK KLNNAANNN- ---GGEIDFV VDDDFE--RR SHQQVVLSGG GSSSSSSSYY SNFLLRMAKK KVNNVVNNN- ---GGELEFV VDDDFR--RR AHQQVVLWGG GSSSSSSSFF TDFVVPQVLL LAHHAAGGG- ---GGTLAWV VEEEFD--RR AHQQIILEGG GSSSSSSSFF TDFVVPEVMM MANNVVGGG- ---GGELDFV VSSSFD--RR AHQQIILEGG GSSSSSSSFF TEFRRGMVMM MANNVVGGG- ---GGTLDWV VDDDFA--RR SHQQIILEGG GSSSSSSSFF APFIIDMVKK KLDDAAGGG- ---GGEFDFL LEEEWK--RR PHQQVVLQGG GSSSSSSSYY AEFIIKMVKK KVDDVVNNN- ---GGQFDFV VDDDFE--RR VHQQIILQGG GSSSSSSSYY SEFIIRIAKK KAEEAADDD- ---GGSLDFT TEEEVD--RR PHQQIILEGG GSSSSSSSYY DKFLLIGSVV VMLLQQVVVD DTTGGKLNLV VDDDFKPPLL AHEELLYPGG GSSIIIIIWW AKFLLIGSVV VMLLQQIIID DTTGGKLNLV VDDDFKPPLL AHEELLYPGG GSSIIIIIWW AKFLLIGSVV VMLLQQIIID DTTGGKLNLV VDDDFKPPLL AHEELLYPGG GSSIIIIIWW AKFLLIGSVV VMLLQQIIID DTTGGTLNLV VDDDFKPPLL AHEELLYPGG GSSIIIIIWW AKFLLIGSVV VMLLQQVVVD DTTGGKLNLV VDDDFKPPLL AHEELLYPGG GSSIIIIIWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AKFLLIGSVV VMLLQQVVVD DTTGGKLNLV VDDDFKPPLL AHEELLYPGG GSSIIIIIWW DKFLLIGSVV VMLLQQIIID DTTGGKLNLV VDDDFKPPLL AHEEIIYPGG GTTIIIIIWW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKFMMIGSVV VMLLQQIIID DTTGGKLNLV VDDDFKPPLL AHEELLYPGG GSSIIIIIWW IKFLLLGAVV VMLLQQIIID DTTGGKLNLV VDDDFKPPLL AHEEIIYPGG GTTIIIIIWW AKFLLVGSHH HILLQQIIID DTTGGKINFV VDDDFAPPLL AHEEMMYPGG GTTIIIIIWW AKFLLVGSHH HILLQQIIID DTTGGKINFV VDDDFAPPLL AHEEMMYPGG GTTIIIIIWW ARFLLMGSHH HIIIQQIIID DTTGGSINFV VDDDFDPPLL AHEEMMYPGG GTTIIIIIWW AVFIIMGSHH HIIIQQIIID DTTGGTINFV VDDDFDPPLL AHEEMMYPGG GTTIIIIIWW REFLLVGSHH HMLLQQIIID DTTGGSINFV VDDDFAPPLL AHEEMMYPGG GTTIIIIIWW KDFHHVGATT TMVVQQVVVN DPPGKEINLI IDDDFKEELL AHEEMMYPGG GTTIIIIIWW KDFNNVGATT TMLLQQIIID DPPGHVINLI IDDDFKPPLL AHEEMMYPGG GTTIIIIIWW TKFVVVGSVV VMLLQQIIID DTTGGTVNLV VDDDFKPPLL AHDDIIFPCG GTTIIIIILL PKFMMVGGTT TIVVQQLLLD DVVGGKLNLV VDDDFGPPLL PHEEMM---- ---------- PKFMMVGGHH HIVVLLIIID DTTGGSLNLV VDDDFNPPLL PHEEMMYPGG GTTIIIIIWW ---------- ---------- ---------- ---------- ---------- ---------- N-----GKDD DDAAQQYYYL AYYDGELVAV VDDDFEGGRR AHIIMMFGSS SYY------- N-----GKDD DDEEQQFFFL LYYDGELKAI IDDDFAKKRR PHQQMMFGAR RYYPPPPPAA PP----- PP----- PPKRR-- PP----- PP----- PP----- PP----- PP----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- NN----- ------- ------- GGLVVAA 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMMNNSAKQQ QEEATCRTAV PPGLLLALLA DDGGAMMQLP TAAAAQQQQS TTPPVVRRAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AAASAIQQQV VVVASPPSSS ESKTRRSVVG LVESSSSSSS SAAVVVKVSS SAVVQAHHHW ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MMMG ---------- ---------- ---------- ---------- ---------- -----LKKKN ---------- ---------- ---------- ---------- ---------- ---------- RRSPPLNNNN NNNTTPPPPP NPASPPPHHR VPLRRRRRLL LVVRRRYTVV VPLLPPPPPH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMMAIIV VPPKKRDDDP TTYYSSSPPP PMAKKKAPPE ---------- ---------- -------MMA AKKKKPDDDP TTYYTTTPPP PDARRRAPPE ---------- ---------- ---------M MSSRRPDDDP TTHHSSSPPP PLAQQQAAAE ---------- ---------- ---------M MTTRRPDDDP TTHHSSSPPP PLAEEEAAAE ---------- ---------- ---------M MTTRRPDDDP TTYYSSSAAA ALAEEEGVVE ---------- ---------- -------MMA ATTKKPDDDP SSYYSSSPPP PLAKKKAPPE ---------- ---------- -------MMV VTTRRPDDDP TTYYSSSPPP PMAKKKAAAE ---------- ---------- -------MMA ASSRRPDDDP TTYYSSSPPP PMAQQQARRE ---------- ---------- ---TTTKCCT TKK--CGGGP GGPPPPPLLL LAM---GRRE ---------- ---------- ---------- ---------- ---------- ------GRRE WWLPPGHGAL IIIAAAARGL LLGTTTQCCG GKK--CGGGP GGPPPPPLLL LAM---GRRE ---------- ---------- ---------- ---------- ---------- --M---GRRE ---------- ---------- ---TTTKCCG GNN--CGGGP GGSSPPPLLL LAM---GRRE ---AAREGFL QQQSSSSQPM MRITTTKCCG GNN--CGGGP GGSSPPPLLL LAM---GRRE ---------- ---------- ---TTTKCCG GNN--CGGGP GGSSPPPLLL LAM---G--- ---------- ---------- ---TTTKCCG GNN--CGGGP GGSSPPPLLL LAM---GRRE GGLGGEPGTQ PPPWWWWSGQ QLQTTTKCCG GDD--CGGGP GGPPPPPQQQ QAM---GRRE NNSQQCGFQN TTTEEEETYC CTVTTTKCCG GNN--CGGGP GGSSPPPLLL LAM---GRRE ---------- ---------- ---TTTKCCG GNN--CGGGP GGSSPPPLLL LAM---GRRE HHARRSVLHM EEEGGGGAVE ETAKKKTCCC CHHAAKGGGP GGAAPPPLLL LAMKKKGRRE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---AAAKCCG GSS--CGGGP GGKKPPPLLL LAM---GRRE ---------M AAATTTTDHG GVN---VNNG GCCKKSGGGP GGAAPPPIII ISM---GRRE ---------M GGGTTTTQHA AVSNNNQQQG GCCKKSGGGP GGAAPPPLLL LAM---GRRE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------RRM MLLVVGGGGP GGAAPPPLLL LAM---GSSE ---------- ---------- -MAAAAACCC CGGAATGGGP GGAAPPPLLL LAMKKKGRRE ---------- ---------- --SLLLKCCH HGG---GGGP GGAAPPPAAA AAI---GRRE ---------- ---------- --PLLLKCCH HGG---GGGP GGAAPPPAAA AAI---GRRE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMMSEES SKKKKCGGGP GGAAPPPLLL LAVNNNGVVE ---------- ---------- ---------- ---------- ---------- --MSSSGRRE ---------- ---------- ---------- ------MMMP GGII------ -ILSSSLDDR --MKKRFG-- --------AL LAGMMMGLLP PFFAAFAAAD EECCSSSPPP PMPIIITQQE --MKKFVSPM HHHFFFFRAL LVGLLLAAAP PAAVVRAAAD EECCSSSPPP PMKIIITQQE DYVAACYTGT GIIIINRAAV VVVVDDVVNN PKKSSEESIV HKLPYINNNN EEHFGGWWAS DYVAAAYVGT GVVVVNAPAV VVVVDDVVDD PKKSSPPGVI YKLPYIGGGG EEHFGGWWAS EYTLLLSPDF S-----RPAV VIIIDDVVKK PGGSSSSGIV HTMPNTGGGG EEHFGGWWAS NYTLLLSPDF S-----KPAV VIIIDDVVKK PGGSSPPGIV HTMPNKGGGG EEHFGGWWAS KFTLLMSPDA S-----KPAV VVVVDDVVDD PTTSSEEGIV HQMPNKGGGG EEHFGGWWAS TYVAAMDPER K-----QPAV VVVVDDVVDD PAASSPPAIV GQMPHAGGGG EEHFGGWWAS KYVVVRNPMA NGGGG-KPCV VVVVDDVVDD SQQSSSSGVV GVMPYTGGGG EEHFGGWWAS RYVAALDPGR E-----RPGV VLLLDDLLDD PDDSSGGAIV GRMPNAAAAA EEHFGGWWAA EYLPPCYRNT GTTTTEAPAT TVVVDDVVDD PKKSSPPSVI HRMPYLKKKK EEHSGGWWTS EYLPPCYRNT GIIIIEAPAT TVVVDDVVDD PKKSSPPSVI HRMPHLKKKK EEHSGGWWTS EYLPPCYGNT GIIIIEAPAT TVVVDDIIDD PKKSSPPCVI HRMPNLRRRR EEHSGGWWAS EYLPPCYRNT GIIIIEAPAT TVVVDDVVDD PKKSSPPCVI HRMPHLKKKK EEHSGGWWTS EYLPPCYRNT GTTTTEAPAT TVVVDDVVDD PKKSSPPCVI HRMPNLKKKK EEHSGGWWTS EYLPPCYRNT GTTTTEAPAT TVVVDDVVDD PKKSSPPCVI E--------- ---------- ---------- -TTTTEAPAT TVVVDDVVDD PKKSSPPCVI HRMPNLKKKK EEHSGGWWTS EYLPPCYRNT GTTTTEAPAT TVVVDDVVDD PKKSSPPCVI HRMPNLKKKK EEHSGGWWTS EYLPPCYRNT GTTTTEAPAT TVVVDDVVDD PKKSSPPSVI HRMPYLKKKK EEHSGGWWTS EYLPPCYRNT GTTTTEAPAT TVVVDDVVDD PKKSSPPCVI HRMPNLKKKK EEHSGGWWTS EYLPPCYRNT GTTTTEAPAT TVVVDDVVDD PKKSSPPCVI HRMPNLKKKK EEHSGGWWTS KYVTTCYNGT GIIIINKLAT TVVVDDLLDD PSSSSPPSVI HRVIHIGGGG KKHSGGWWSS ---------- ---------- ---------- ---------- --MPNTNNNN EEHSGGWWTS EYLPPCYRST GIIIINKPAT TVVVDDVVDD PKKSSPPSVI HRMPNVNNNN EEHSGGWWTS SYVTTAYAGT GIIIIEKPAT TVVVDDVVDD PSSSSPPSVI HRVPYVGGGG EEHTGGWWSS TYVTTAYAGT GIIIIEKPAT TVVVDDLLDD PNNSSPPSVI HRVPYVGGGG EEHTGGWWSS ---------- ---------- ---------- ---------- --MPFVGGGG EEHSGGWWSS KYVTTAYTGT GIIIIDKPAT TVVVDDVVDD PSSSSPPSVI HRMPFVGGGG EEHSGGWWSS KYVTTCYNGT GIIIINKPGT TVVVDDVVDD PNNSSPPSVI HRVTHVGGGG EEHSGGWWAS EFVTTA---N AAAAADGPFT TVVVDDVVNN PEESSDDCVI SRVPHIGGGG EEHTGGWWAS EFVTTA---H ARRRRDGPFT TVVVNNVVNN PEESSEECII SRVPNIGGGG EEHTGGWWAS ---------- ---------- ---------- ---------- ---------- ---------- KYVVVCQPNL DEEEEEHGAT TVVVDDVVDD PAASSPPCVI HRTNSKHHHH EEHSGGWWTS KYTVVTQPNL DEEEEPHGST TVVVDDVVDD PEESSPPCIV HRTNRKGGGG EEHSGGWWAS FFSNNWHGDI RQQQQYDIKN NPPPRRMMVV GQQVVFFGVL KDVKVLEEEE KKDSQQPPPL EYVWWTGVEG MGGGGDEQVT TIIIDDLLRR PGGSSAAGVI NSVGG-RRRR EEHGGGFFA- DYVWWTGAEG VGGGGDEQVT TVVVDDAANN PKKSSPPGVV NTVGG-RRRR EEHSDDFFD- CCNNG--KNN NIIIIRRRLI IVLRRRIYYI IIDTKNNRRP KIEEPEVKVV GGSSTVVVVH CCNNA--KFF FLLLLRRRLI IVLRRRIYYI VVDTKDDRRP KVEEPEAVRR GGTTTVVVVH SSLLTGGHFF FLLLLRRRLI IILRRRIYYV IIDTKHHTTA KIEEPDILKK GGSSTVVVVH SSLLAGGHFF FIIIIRRRLI IILRRRIYYI IIDTKDDTTA KIEEPEVFKK GGSSTIIIIH SSLLTGGHFF FLLLLRRRLI IIIRRRIYYI VVDVKEELLA KIEEPEVFKK GGSSTIIIIH CCNNAPPHHH HMMMMRRRLV VVLRRRIYYI LLDTKDDLLP KIEEPELARR GGSSTVVVVH CCNNAPPHHH HVVVVRRRLV VVIRHHITTI LLDTKDDTTP KIDDPNLARR GGAATVVVVH CCYYAPPHHH HVVVVRRRLI IVIRRRIHHI VVDTKDDRRP KIEEPELHRR GGSSTIIIIH ----FGGDTT TKKKKRRRLI ILLMRRIYYV VVDVGEERRP KIEEASIQKK NNSSTSSSSH ----FGGDTT TKKKKRRRLI ILIIRRIYYV VVDVGEERRP KIEEPNIHKK NNGGTSSSSH ----FGGDTT TKKKKRRRLM MLLMRRIYYV VVDVGDDRRP KIEEAEIHKK GGGGTSSSSH ----YGGDTT TKKKKRRRLV VLLIRRIYYV VVDVGEERRP KIEEPKIHKK NNGGTSSSSH ----FGGDTT TKKKKRRRLV VLLIRRIYYV VVDVGEERRP KIEEPEIHKK EEAATSSSSH ---------- ---------- ---------- ---------- ----PKIHKK EEAATSSSSH ----FGGDTT TKKKKRRRLV VLLIRRIYYV VVDVGEERRP KIEEPKIHKK EEAATSSSSH ----FGGDTT TKKKKRRRLV VLLIRRIYYV VVDVGEERRP KIEEPKIHKK EEAATSSSSH ----FGGDTT TKKKKRRRLV VLFIRRIYYV VVDVGEERRP KIEEAKIHKK GGGGTSSSSH ----FGGDTT TKKKKRRRLV VLL------- ---------- ---------- ---------- ----FGGDTT TKKKKRRRLV VLLIRRIYYV VVDVGEERRP KIEEPKIHKK EEAATSSSSH ----HGGDSS SAAAARRRLI ILLLRRVYYV VVDTADDRRP KVEESEIANN GGGGTSSSSH ----YGGDSS SKKKKRRRLI ILLIRRIYYV VVDVGDDRRP KVEEPYVFKK GGAATSSSSH ----YGGDSS SKKKKRRRLI ILLIRRIYYV VVDVGDDRRP KVEEPYVFKK GGAATSSSSH ----HGGDSS SAAAARRRLI IALVRRIYYV IIDTKNNRRP KVDDPAIIKK GGAATSSSSH ----HGGDSS SAAAARRRLI IVIVRRVYYV IIDTKNNRRP KVEEPEISKK GGAATSSSSH ----HGGDSS SAAAARRRLV VLLIRRIYYA IIDTKNNRRP KVDDPKIAKK GGAATAAAAH ----HGGDSS SVVVVRRRLV VLLIRRIYYA IIDTKNNRRP KVDDPKIAKK GGAATAAAAH ----HGGDSS SAAAARRRLI ILLLRRVYYV VVDTLDDRRP KVEEAEIAKK GGGGTSSSSH ----HDDKTT TEEEERRRLI IVLNRRIYYI IINVEEERRI HIEEPSLHLL --SSTSSSSH ----HDDKTT TEEEERRRLI IVLNRRIYYV IINVEEERRI HIEEPSLHLL --SSTSSSSH ---------- --------MV VPLSVVEGGK VVFVG----- ---------- ---------- FF--GGGKVV VPPPPRRRLV VLLNRRIFFV IIDTGDDRRP KIEEG-VLGG DDTTTTTTTH YYEESSSKVV VPPPPRRRLV VLLNFFIYYI LLDVVDDRRP KIDDG-VLSS NNTTTTTTTH -----GGKVV VQQQQGGGML LQLDRRLYYV TTTSLSSWWK P-----LIFF VVAATAAAAD ---------- -----RRRFW WTLDRRIFFI FFDVHDDSSP KIDDT-VKSS GGVVTFFFFF ---------- -----RRRLW WALDKKIFFV FFDVHDDAAP KITTD-VESS GGVVTLLLLY HHCCCCGPDA AAAIYIIISS AALNEG-EPG GIMMHFLLKK WEDDRRDDQY YY-------- HHCCCCGPDA AAAIYIIISS AALGDGREPG GILLHFIIRR WEYYRRPPQY YY-------- HHCCCCGPEG GGGIYVVVSS TTLGDGTDAG GIIICFLLRR WEDDRRPPQD DD-------- HHCCCCGPDG GGGIYVVVSS TTLGDGTNPG GVIICFLLRR WEDDRRPPQT TT-------- HHCCCCGPEG GGGIYVVVSS TTLGDGTDPG GIIICFLLRR YEDDRREEQT TT-------- HHCCCCGPGG GGGIYVVVTT AALNEG-KPG GIMMAFLLRR WEEERRPPQY YY-------- HHCCCCGPDG GGGIYIIISS AALSEG-EPG GIIIHLLLRR WEDDRRDDQY YY-------- HHCCCCGPDG GGGVYVVVSS AALSEG-DPG GVVVHFLLRR WEEERRPPQQ QQ-------- HHCCCCLASG GGGEVMMMVV NNTGLQGNKS SFLLGFKKTT WEPPGGAASP PP-------- HHCCCCLASG GGGEVMMMII SSSGPQGNKG GFLLGFKKTT WEPPGGEEAP PP-------- HHCCCCLASG GGGEVMMMII SSTGSKGNKG GFLLGFKKTT WEPPGGAAAP PP-------- HHCCCCLPSG GGGEVMMMVV SSTGPEGNKG GFLLGFKKTT WEPPGGAAAP PP-------- HHCCCCLASG GGGEVMMMII SSSGVKGNKG GFLLGFKKTT WEPPGGAAAP PP-------- HHCCCCLASG GGGEVMMMII SSSGVKGNKG GFLLGFKKTT WEPPGGAAAP PP-------- HHCCCCLASG GGGEVMMMII SSSGVKGNKG GFLLGFKKTT WEPPGGAAAP PP-------- HHCCCCLASG GGGEVMMMII SSSGVKGNKG GFLLGFKKTT WEPPGGAAAP PP-------- HHCCCCLPTG GGGEVMMMII SSTGPKGNKG GFLLGFKKTT WEPPGGSSAP PP-------- ---------- ---------- ---------- ---------- ---------- ---------- HHCCCCLASG GGGEVMMMII SSSGVKGNKG GSVVPLSS-- ---------- ---------- HHCCCCLASG GGGDIMMMII SSCGKEGNAN NGLLDFKKRR GSRRLLPPIS SS-------- HHCCCCLGCG GGGEIMMMII SSSGPYGNKG GFLLGFKKNN WEEEGGAAAP PP-------- HHCCCCLGCG GGGEIMMMII SSSGPCGNKG GFLLGFKKNN WEEEGGSSAQ QQ-------- HHCCCCLASG GGGELMMMII SSCGKDGNEN NGLLDFKKRR WEPPGGSSPL LL-------- HHCCCCLASG GGGEIMMMII SSCGKDGNEN NGLLDFKKRR WEPPGGSSPL LL-------- HHCCCCLASG GGGEILLLVV SSCGEEGNKN NGLLDFKKRR WEPPGGSSPL LL-------- HHCCCCRT-G GGGEILLLVV SSCGEEGNKN NGLLDFKKRR WEPPDDSSPL LL-------- HHCCCCLASG GGGEIMMMII SSCGKEGNAN NGLLDFKKRR WEPPGGSSPL LL-------- HHCCCCLADG GGGNIMMMII SSTGANGTSN NFLLGFKKTT WPDDEETTVP PP-------- HHCCCCLADG GGGNIMMMII SSTGADGSSN NFLLGFKKTT WPDDGGVVVP PP-------- ---------- ---------- ---------- ---------- ---------- ---------- HHCCCCLPNG GGGNIMMMII SSIGAEGNK- -DVVDFVVTT WSGGDDKKAL LL-------- HHCCCCLANG GGGNIMMMII SSVGAEGYK- -DIIDFIITT WTGGDDKKAL LL-------- DDYYYYQPNT TTTALKKKQQ DDGNSLSVVN NGQQKNSSKK GESSQQEEEI II-------- FFAAAALPGS SSSMMIIITT GGLNDDHGRA ALEEDEAAYY WMTTAADDMQ QQAVAVVGGD YYAAAALPGR RRRMLIIITT GGLNKDHGRA ALEENEAAHH WITTDDDDLR RRAIKTTGG- -----AAYYD FWWNNNLL-P ELVVEWWAAV PN---TIEED GLEELKKK-- YGNNNRIIHH -----AAYYD FWWNNNLL-P GMIIEWWTTV PR---CFEEE GLEELKKKGG YGNNNKLLHH -----HHYYD FWWNNNLL-P DMVVEWWAAL PP---QFEEN GPEELLLLNN YGHHHRLLHH -----HHYYD FWWNNNLL-P DMVVEWWAAL PP---QFEEN GPEELLLLNN YGHHHRLLHH -----HHYYD FWWNNNLL-P DMVVEWWGGL PP---QFEEN GPEELLLLNN YGHHHKIIHH -----AAYYD GWWHHHLL-G DLVVEWWGGT PD---MVEED GPDDLLLLAA YGRRRRLLHH -----HHYYD FWWHHHLL-G DLLLEWWGGT PR---MVEES GGDDLLLLGG YGHHHRLLHH -----AAYYD FWWHHHLL-G DMVVEWWGGT PN---MIEEG GPQQLLLLKK YGRRRRLLHH -----GGYYD FWYQQQPP-R NMVVEWWAAA PN---VFKKD GAHHEAAAGG YGSSSRIIFF -----GGYYD FWYQQQPP-R NMVVEWWAAA PN---VFKKD GAHHEAAAGG YGSSSHIIHH -----GGYYD FWYQQQPP-R NMIIEWWAAA PN---VFRRD GADDEAAAGG YGSSSHLLHH -----GGYYD FWYQQQPP-R NMIIEWWAAA PN---VLRRD GADDKAAAGG YGSSSHLLYY -----GGYYD FWYQQQPP-R NMIIEWWAAA PN---VLRRD GADDEAAAGG YGSSSHLLYY -----GGYYD FWYQQQPP-R NMIIEWWAAA PN---VLRRD GADDEAAAGG YGSSSHLLYY -----GGYYD FWYQQQPP-R NMIIEWWAAA PN---VLRRD GADDEAAAGG YGSSSHLLYY -----GGYYD FWYQQQPP-R NMIIEWWAAA PN---VLRRD GADDEAAAGG YGSSSHLLYY -----GGYYD FWYQQQPP-R NMIIEWWAAA PN---VVQQN GADDEAAAGG YGKKKHLLHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----ISSAAH SN---LRLLT GYPPSAAASS VAGGGITT-- -----EERRT HLYEEENNYA GFWWIQQCCC SL---FYTTT GMCCTAAASS VHVVVISSCC -----GGYYD FWYQQQPP-R NMIIEWWGGA PK---AFAAL GEEEQAAAGG YGHHHSLLNN -----GGYYD FWYQQQPP-R NMIIEWWGGA PK---AFAAL GEDDQAAAGG YGHHHSLLNN -----GGYYD FWYQQQPP-R NMIISWWGGA PT---AFTTK GQHHADDDGG YGRRRHLLTT -----GGYYD FWYQQQPP-R NMIISWWGGA PK---AFLLQ GQHHADDDGG YGRRRHLLHH -----GGYYD FWYQQQPP-R KMIISWWGGA PK---AFSSK GQHHADDDGG YGSSSHLLHH -----GGYYH FWYQQQPP-R KMIISWWGGA PK---AFSSK GQHHADDDGG YGSSSHLLHH -----GGYYD YWYQQQPP-R KMIISWWGGA PA---AFRRT GQHHQDDDGG YGRRRHLLHH -----NNYYD FWYQQQPP-R NMIIEWWGGS PN---HIKKK GAHHGEEEGG YGNNNSVVHH -----NNYYD FWYQQQPP-R NMIIEWWGGS PN---HIKKK GAHHPEEEGG YGNNNSVVHH ---------- ---------- ----LRRGGG PV---TVCCR DKCCPEEEPP VIKKKCKKRR -----GGYYD YWYQQQPP-H NMVVEWWGGA PK---LFRRR GTDDDDDDTT YGCCCRLLNN -----GGYYD FWYQQQPP-Y DMVVEWWGGA PN---KWRRR GVDDEDDDSS YGCCCRLLNN -----QQLLS NHNNNNGG-- ESEERPPDDE PI---MAFFE SFLLKTTTPP KPQQQHVVAA AVVAGGGYYD IRALLLII-R NMLLSFFTTG WSYYYMMDDF GQDDEAAAKK FGNNNTIIVV KYYAGDDYYD VRALLLPP-R NLVVSFFTTG WNYYYMMDDF GADDEAAAKK FGNNNTVVVV DKKKIIHSST GGERMMAAAL L----ELLLH HDDPTTKLMM IINMVVVSSS IIWWLLFY-E DKRRLLYAAD GGQRMMVVVL L----EVLLH HDDPTTKLMM VVNVVLLSSS IIWWLLFY-E DARRVVQTTD GGAQMMAAAL L----EVAAH HDDPVVREYY VVGVVVVEGS IIWWTTWR-E DARRVVQTTD GGAQMMAAAL L----EVAAH HDDPVVREYY VVGVVVVEAS IIWWTTWR-E KDKKVVQTTD GGAQMMAAAL L----EIAAH HDDPSSKDYY CCGVVVVQGA IIFFTTWQKD DRRRLLQEED GGDQLLVVVF F----ELAAH HDDPTTKAYY VVNCVIISSS IIWWTTYR-D DRRRLLQTTD GGAQMMAAAL L----ELAAH HDDPTTKAYY MMNCVVVSAS IIWWLLYR-D DRRRLLQAAD GGEQMMVVVL L----ELAAH HDDPAARTYY VVGVVVVSAS VVWWLLHR-Q DREEIIQTTQ TT-GLLIIIP P----EILLH HDDPSSATQQ VVGCALLRFY KKNNEEG--- DREEIIQTTQ KK-GLLIIIP P----EILLH HDDPDDATQQ VVGCALLRFY KKNNEEG--- DREEIIQTTT QQ-GLLIIIP P----EILLH HNNPDDAAQQ VVGCALLRFY KKNNQQG--- DREEVVQTTP QQ-GLLIIIP P----EILLH HNNPDDAAQQ VVGCALLRFF KKNNEEG--- DHEEVVQTTS KK-GLLIIIP P----EILLH HNNPDDAAQQ VVGCALLRFY KKNNEEG--- DREEVVQTTS KK-GLLIIIP P----EILLH HNNPDDAAQQ VVGCALLRFY KKNNEEG--- DREEVVQTTS KK-GLLIIIP P----EILLH HNNPDDAAQQ VVGCALLRFY KKNNEEG--- DREEVVQTTS KK-GLLIIIP P----EILLH HNNPDDAAQQ VVGCALLRFY KKNNEEG--- DREEVVQTTL PP-GHHIIIP P----EILLH HDDPAAASQQ VVGCALLRFY KKNNEEG--- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NMVVDDESSP QQ-QAAGGGA ANNPICLIIH HWWKNNINQQ DDVVEVVGGS DDPPDDY--- DERRIIQTTD GGEGLLIIIP P----EILLH HDDPDDAAQQ VVGCALLRFY KKEEKKG--- DERRVVQTTD GGKGLLIIIP P----EILLH HNNPDDADQQ VVGCALLRFY KKEEKKG--- QREERRQTTD GGNGLLLLLP P----EILLH HDDPAAKDTT VVGSALLRFF KKTTQQG--- SGEEKKQTTD GGDGLLLLLP P----EILLH HDDPAAKDTT VVGSALLRFF KKTTQQG--- SGEEKKQLLD GGEGLLLLLP P----EILLH HDDPSSKDTT VVGSALLRFF KKNNSSD--- SGEEKKQLLD GGPGLLLLLP P----EILLH HDDPSSKDTT VVGSALLRFF KKNNSSE--- DGEEKKQTTD GGSGLLLLLP P----EVLLH HDDPSSKDTT VVGCALLRFF KKTTAAG--- ESKKLLQTTD PPQGAALLLP P----EVLLH HEEPTTSEHH VVGCALLRIH PPVVEENS-- ETKKLLQTTD PPMGAALLLP P----EVLLH HEEPTTSEHH VVGCALLRIH PPDDEENP-- ---------- ---------- ---------- ---------- ---------- ---------- REEEFFQTTD GGDGLLTTTP P----EILLH HNNPRRENQQ VVGCAFFXXX ---------- KTTTYYQTTD GGSGIITTTP P----EILLH HNNPKKKAEE VVGCALLHFK KKKKSSSD-- L--------- ---------- ---------- ---------- ---------- ---------- DTQQKKKVVN PPG------- -----EIPPW WGGSNNANYY SSTTALLLIY EEDDDDG--- DTQQKKKVVD PPG------- -----EIAAW WGGEAAHNYY TTSTALLLIY EEDDGGG--- DEIIEPPAEE LEGGLLPPPI AVPPLLLTID DISSSDLLYL SWGGIGGRQQ YDIISSNPFP DEIIDEEAQQ FEGGLLPPPV MVPPLLLTID DISSSDLLYV SWGGLGGRQQ YDIITTNPHP GKAATPPAEE ATAALLPPPL AVPPLLLTID DLSSSDLLYV SWGGTGGRQQ YDVVSSDPHP GEAATPPPEE APKKLLPPPL AVPPLLLTID DLSSSDLLYV SWGGTGGRQQ YDVVSSDPRP DKIITDDPVV ADAALLPPPL ACPPLLLTID DLSSSDLLYV AWGGLGGHQQ YDVVSSDPMP KRIIEPPAEE ADPPLLPPPV AVPPLLLTID DLSSSDLLYV SWGGTGGLQQ YDVVSSDPFP NKIIDPPAEE ASEELLPPPI AVPPLLLTIN NLSSSDLLYV SWGGTGGHQQ YDVVSSDPFP NRIIEPPAEE AEPPLLPPPL AVPPLLLTIN NLSSSDLLYV SWGGTGGRQQ YDVVSSDPFP --TTWVVEKK IQVVKKKKKK EMPGLLLTIL LLSSSDLLYF SWLLHGGRQQ YDIISSNPQP --TTWVVEKK IQVVKKKKKK EMPGLLLTIL LLSSSDLLYF SWLLHGGRQQ YDIISSNPKP --TTWVVEKK IQVVKKKKKK EMPGLLLTIL LLSSSDLLYF SWLLHGGRQQ YDIISSDPQP --TTWAAQKK IQVVKKKKKK EMPGLLLTIL LLSSSDLLYF SWLLHGGRQQ YDVVSSDPQP --TTWVVEKK IQVVKKKKKK EMPGLLLTIL LLSSSDLLYF SWLLHGGRQQ YDIISSDPQP --TTWVVEKK IQVVKKKKKK EMPGLLLTIL LLSSSDLLYF SWLLHGGRQQ YDIISSDPQP --TTWVVEKK IQVVKKKKKK EMPGLLLT-- ---------- ---------- ---------- --TTWVVEKK IQVVKKKKKK EMPGLLLTIL LLSSSDLLYF SWLLHGGRQQ YDIISSDPQP --TTWVVEKK IEVVKKKKKK EMPGLLLTIL LLSSSDLLYF NWLLHGGRQQ YDIISSDPKP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --AAVLLKRR LDLLAAVVVA SLSNEEEPAW WIFFFSIIIF L--------- ---------- --KKWAAEKK IKVVKKKKKE EMPGLLLTIL LISSSDLLYF SWLLHGGRQQ YDIITTDPRP --KKWAAEKK IQVVKKKKKE EMPGLLLTIL LISSSDLLYF SWLLHGGRQQ YDIITTDTRP --SSWHHELL IPVVLLKKKQ EMPGLLLTFL LISSSDLLYF VWLLHGGRQQ YNIIEEDLKP --SSWHHEII ISVVLLKKKQ EMPGLLLTFL LISSSDLLYF VWLLHGGRQQ YNIIEEDVKP --TTWYYEII ISVVLLKKKE EMPGLLLTFL LISSSDLLYF VWLLHGGRQQ YNIIEEDPKP --TTWHHEVV ISVVLLKKKE EMPGLLLTFL LISSSDIIYF VWLLHGGRQQ YNIIEEDPKP --SSWHHEVV ISIILLKKKR EMPGLLLTFV VISSSDLLYL VWLLHGGRQQ YNIIEEDPAP --TTHAATLL AFIIKKKKKS EMPALLLTIL LISSSDLLYV SWLLHGGRQQ YDIISSDPLV --VVQAASLL ATIIKKKKKE DMPALLLTIL LISSSDLLYV SWLLHGGRQQ YDIISSDPKP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------QQQE MMGGMMMTIL LISSSDLLYF SWRRHGGRQQ YDIISSDRAP --EEAKKVII IPGGVVDDDG DMGGMMMSII IISSSDLLYV NWRRHGGRQQ YDIITTDPEP ---------- ---------- ---------- ---------- ---------- ---------- ---------- -EWWKKAAAA ADIPLLLVIS SIAAADLLWI NFMMDGGRLL FDIISSDPHP ---------- -EWWKKAAAA AKVPLLLVIS SISSSDLLWV NFMMDGGRLL FDIISSDPHP VVLLGKLGIF FHHAAPP--- ---------- ---GKLTGGA QQQQQMLIIS SSRRVYYYVT RRLLGRIGLY YHHEEPP--- ---------- ---GEATGGA QQQQQMIVVS SSRRVYYYIT VVLLGSIGIA ARRAAPP--- ---------- ---GTFAGGG QQQQQMVIIS SSRRVYYYWT KKLLGSIGIA ARRTTPP--- ---------- ---GAFAAAG QQQQQMVIIS SSRRVYYYWT VVLLGKIGIV VKKTTPP--- ---------- ---GTFGYYG QQQQQMVIIS SSRKVYYYWT KKLLGKIGIV VSSAAPPGG- ---------- ---NALNGGG QQQQQMVIIS SSRRVYYYFT RRLLGKIGIV VRRAAPP--- ---------- ---SELNGGG QQQQQMVIIS SSRRVYYYFT RRHHGSLGIV VRRAAPP--- ---------- ---SPLNGGG QQQQQMVVVS SSRRVYYYFS RRLLGQLGSI IVVGGVVQQV VL-DQECPPP PLVGRIPGGG QQQQQMILLS SSLKLYYYAT RRLLGQLGSI IVVGGVVQQV VL-DQECPPP PLVGRVPGGG QQQQQMILLS SSLKLYYYVT RRLLGQLGSI IVVGGVVQQV VL-DQESPPP PLVGKVPGGG QQQQQMILLS SSLKLYYYVT RRLLGQLGSI IVVDDVVQQV VL-DQESPPP PLVGQVAGGG QQQQQMILLS SSLKLYYYVT RRLLGQLGSI IVVGGVVQQV VL-DQESPPP PLVGRVAGGG QQQQQMILLS SSLKLYYYIT RRLL------ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RRLLGQLGSI IVVGGVVQQV VL-DEESPPP PLVGRVAGGG QQQQQMILLS SSLKLYYYIT RRLLGQLGSI IVVGGVVQQV VL-DQESPPP PLVGRVPGGG QQQQQMILLS SSLKIYYYVT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KKLLGQLGSI ILLGGVVTTV VL-DKDCPPP PVIGKVPGGG QQQQQMILLS SSLKLYYYVT KKLLGQLGSI IQQGGVVTTV VL-DKECPPP PVTGIIPGGG QQQQQMILLS SSLKIYYYVT VVLLGQVGLI IQQGGVVAAA AI-EDGWSSV VPEGKLRGGG QQQQQMILLT TTLKLYYYVT KKLLGQAGLI IQQGGVVVVA AV-DDGWSSV VPEGKLRGGG QQQQQMILLS SSLKLYYYVT VVLLGQVGLL LQQGGVVKKA AV-EDGFFFV VPQGSLRGGG QQQQQMILLS SSLKLYYYAT VVLLGQVGLL LQQGGVVKKA AV-EDGFFFV VPQGSLRGGG QQQQQMILLS SSLKLYYYAT VVLLGQAGLL LQQGGVVVVY YV-EDDEYYV VPQGRLRGGG QQQQQMILLS SSLKIYYYVT KKLLSQIGSV VHHEEVVKKV VL-GEK-IIA ALYGKIEGGG QQQQQMLLLS SSLKLYYYVT KKLLSQIGSI IHHEEVVKKV VL-EDH-IIA ALYGQIEGGG QQQQQMLLLS SSLKLYYYVS ---------- ---------- ---------- -------GGG AAAAAKILLS SSVKLYYYVT RRLLGQLGAI IQQDDRRRRV VL-DPEEPPP PVFGRLLGGG QQQQQMLLLS SSLRLYYYVS KKLLGQLGAI ICCDDNNVVI IVEDKEEPPA ARYGRLEGGG QQQQQMLLLS SSLKLYYYVS ---------- ---------- ---------- ---------- ---------- ---------- FFQQYEIDQV VNN------- ---------- ---------- -----MVQQS SSWKVYYYFS RRQQYEIGQV VNN------- ---------- ---------- -----MVSSS SSWQLYYYYT TNNSLLYWDD NYPLLLKKML NAA------S GGGGGEIKEE FVDFFGE--- -RRSVSGGSS TNNSLLYWNN NYPLLLRRMV NVV------E GGGGGELKEE FVDFFGR--- -RRAVWGGSS TNNSLLYWDD DYPVVVPPQA HAA------D GGGGGTLDDD WVEFFPDGG- -RRAIEGGSS TNNSLLYWDD DYPVVVPPEA NVV------N GGGGGELKDD FVSFFPDGG- -RRAIEGGSS TNNSLLYWDD EYPRRRGGMA NVV------N GGGGGTLKDD WVDFFPAGG- -RRSIEGGSS TNNSLLYVDD PYPIIIDDML DAA------N GGGGGEFPKK FLEWWPKGG- -RRPVQGGSS TNNSLLYWDD EYPIIIKKMV DVV------D GGGGGQFPNN FVDFFGE--- -RRVIQGGSS SNNSLLYWDD EYPIIIRRIA EAA------G GGGGGSLPGG FTEVVGDGG- -RRPIEGGSS TTTSLLYWDD KY-LLLIIGM LQQDDDDTTN GGGGGKLPNN LVDFFGKEEP GLLALPGGSS TTTSLLYWDD KY-LLLIIGM LQQDDDDTTN GGGGGKLPNN LVDFFGKEEP GLLALPGGSS TTTSLLYWDD KY-LLLIIGM LQQDDDDTTK GGGGGKLPNN LVDFFGKEEP GLLALPGGSS TTTSLLYWDD KY-LLLIIGM LQQDDDDTTK GGGGGTLPNN LVDFFGKEEP GLLALPGGSS TTTSLLYWDD KY-LLLIIGM LQQDDDDTTK GGGGGKLPNN LVDFFGKEEP GLLALPGGSS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TTTSLLYWDD KY-LLLIIGM LQQDDDDTTK GGGGGKLPNN LVDFFGKEEP GLLALPGGSS TTTSLLYWDD KY-LLLIIGM LQQDDDDTTK GGGGGKLPNN LVDFFGKEEP GLLAIPGGTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TNNSLLYWDD KY-MMMIIGM LQQDDDDTTK GGGGGKLPNN LVDFFGKEEP GLLALPGGSS TSSSLLYWDD KY-LLLLLGM LQQDDDDTTK GGGGGKLPNN LVDFFGKEEP GLLAIPGGTT TNNSLLFWDD KY-LLLVVGI LQQDDDDTTK GGGGGKIPNN FVDFFGAEEP GLLAMPGGTT TNNSLLFWDD KY-LLLVVGI LQQDDDDTTN GGGGGKIPNN FVDFFGAEEP GLLAMPGGTT TNNSLLFWDD RY-LLLMMGI IQQDDDDTTK GGGGGSIPNN FVDFFGDEEP GLLAMPGGTT TNNSLLFWVV VY-IIIMMGI IQQDDDDTTK GGGGGTIPDD FVDFFGDEEP GLLAMPGGTT TNNSLLFWDD EYGLLLVVGM LQQDDDDTTK GGGGGSIPNN FVDFFGAEEP GLLAMPGGTT TTTSLLYWDD DY-HHHVVGM VQQNNNDPPS GGGKKEIRDD LIDFFGKIIE GLLAMPGGTT STTSLLYWDD DY-NNNVVGM LQQDDDDPPT GGGHHVIKNN LIDFFGKVVP GLLAMPGGTT TNNSFFYWDD KY-VVVVVGM LQQDDDDTTK GGGGGTVKNN LVDFFGKEEP GLLAIPCGTT SSSSLLFWDD KY-MMMVVGI VQQDDDDVVN GGGGGKLENN LVDFFGGEEP GLLPM----- SSSSLLYWDD KY-MMMVVGI VLLDDDDTTN GGGGGSLEDD LVDFFANEEP GLLPMPGGTT ---------- ---------- ---------- ---------- ---------- ---------- SSSSLLLWDD --------GD AQQLLLAYYW DDDGGELEDD AVDFFYELLG GRRAMGSSYY TSSSLLLWDD --------GD EQQLLLLYYW DDDGGELEQQ AIDFFYAEEK GRRPMGARYY DSCYY-- DSCYY-- DSCYY-- DSCYY-- DSCYY-- DSCYY-- DSCFF-- DSCYY-- DII---- DII---- DIL---- DIL---- DII---- ------- ------- DII---- DIL---- ------- ------- ------- DIV---- DII---- DII---- DII---- DII---- DII---- DII---- DII---- DII---- DIA---- ------- DILAA-- ------- S------ GPGDDAR 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSAKEATT TCCTAAAVTG GTAARRLLLL AADDGAQQQQ RQLLLSLLLL LTTPVVRRIA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YYYQQQAAAW WWTTSSAIIL ASSSSSRRSS KGRSGSSSAA AVAAVVPPSA AVVQWAHPPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AER ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MGKE ---------- ---------- ---------- ---------- ---------- ----LLKQGC ---------- ---------- ---------- ---------- ---------- ---------- MMMAAARRSA AAPPLPPLLR TPPTTTHHPP LAPPRRRLVV VRPPIINNVP PLLPCPPRHS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------KRR ---------- ---------- ---------- ---------- ---------- -------KRF ---------- -------MII IPPPFKPPTF FFYSPPKMAM KAADLAAVAC CCCGGTTIIN ---------- --------MM MKKKLKPPTF FFYTPPRDAM RAADIAAVAA AAAGGTTVVN ---------- ---------- -SSSMRPPTF FFHSPPELAM QAAEFAATLL LLLDDFF--- ---------- ---------- -TTTMRPPTF FFHSPPKLAM EAANFAATLL LLLDDFF--- ---------- ---------- -TTTLRPPTF FFYSAAKLAM EGGKLAATLM MMMDDAA--- ---------- --------MM MTTTWKPPSF FFYSPPRLAA KAATIAAVAM MMMEERR--- ---------- --------MM MTTTWRPPTF FFYSPPRMAV KAAKLAAVVR RRRMMAAGG- ---------- --------MM MSSSWRPPTF FFYSPPKMAM QAARLGGVAL LLLGGRR--- ---------- -----MMTCC CKKK--PPGY YYPPLLEAMK -GGEIVVLPC CCCNNTTTTE ---------- ---------- ---------- ---------M -GGEIVVLPC CCCNNTTIIE KHAVVVAPPA GGLPAHHTCC CKKK--PPGY YYPPLLEAMK -GGEIVVLPC CCCNNTTIIE ---------- ---------- ---------- --------MK -GGEIIILPC CCCNNTTIIE ---------- -----MMTCC CNNN--PPGY YYSPLLEAMK -GGEIVVLPC CCCNNTTTTE AEFTTTSVVA PPMPSTTTCC CNNN--PPGY YYSPLLEAMK -GGEIVVLPC CCCNNTTTTE ---------- -----MMTCC CNNN--PPGY YYSPLLEAMK -GG------- -------TTE ---------- -----MMTCC CNNN--PPGY YYSPLLEAMK -GGEIVVLPC CCCNNTTTTE EPTAAAWFFL GGQWDTTTCC CDDD--PPGY YYPPQQEAMK -GGEIVVLPC CCCNNTTTTE LGQTTTELLH YYCLTSSTCC CNNN--PPGY YYSPLLEAMK -GGEIVVLPC CCCNNTTTTE ---------- -----MMTCC CNNN--PPGY YYSPLLEAMK -GGEIVVLPC CCCNNTTTTE LVHIIIGAAA VVEAANNKCC CHHHTAPPGY YYAPLLEAME KGGKLVVVTC CCCGGTTIIN ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------ACC CSSS--PPGY YYKPLLDAMK -GGEIVVLPC CCCSSTTIIN ------TVVL HHGVKKK-NN NCCCCKPPGY YYAPIIESMS -GGSLIIVTA AAAGGTTIIE ------TVVL HHAVKVVNQQ QCCCCKPPGY YYAPLLEAMS -GGTLIIVTA AAAGGTTIIE ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------RR RLLLQVPPGY YYAPLLAAMS -GGKLIIVTA AAAGGTTIID ---------- ---AANNACC CGGGGAPPGY YYAPLLEAME KGGKLLLVTC CCCGGTTIIN ---------- ---MNCCLCC CGGG--PPGY YYAPAADAIK -GGEVLLVTA AAA--NNAAD ---------- ---M-CCLCC CGGG--PPGY YYAPAADAIK -GGEVLLVTA AAA--HHRRD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MEE EKKKCKPPGY YYAPLLDAVR NGGKLLLVVC CCCNNLLEEE ---------- ---------- ---------- --------MR SGGKLLLTVT TTTNNLLEEP ---------- ---------- ------PPGL LLI---DILI SLLFLYYSNW WWWDDIIQQY EF-------- AALAALLMLL LFFFRADDET TTCSPPYMPK ITTEFVVVWT TTTEEGGGGD IVPSSSFAAL AALSALLLAA AAAAGVDDET TTCSPPYMKK ITTDYVVVWT TTTEEGGGGD AAADFAVVDV NNPSETTYYS VVHHHKVVEP YYINNDDDEL HHGWWWNCSA LLCCPPKKKK PPPDFAVVDV DDPSPTTYYG IIYYYKLLDP YYIGGDDDEL HHGWWWNCSA YYCCPPKKKK PPPDAAVIDV KKPSSTTYYG VVHHHTVVTP NNTGGDDDEF HHGWWWNCSS LLSSPPHHHH PPPDAAVIDV KKPSPTTYYG VVHHHTVVTP NNKGGDDDEF HHGWWWNCSA LLSSPPHHHH PPPDGAVVDV DDPSEKKFFG VVHHHQLLIP NNKGGDDDEF HHGWWWNCSA LLSSPPHHHH PPPDAAVVDV DDPSPRRYYA VVGGGQVVAP HHAGGDDDEL HHGWWWNCSC LLCCPPHHHH PPPDACVVDV DDSSSTTFFG VVGGGVTTDP YYTGGGGGEL HHGWWWNCSM LLCCPPHHHH PPPDAGVLDL DDPSGTTYYA VVGGGRVVEP NNAAADDDEL HHGWWWNCSA LLCCPPHHHH PPPDYATVDV DDPSPQQYYS IIHHHRLLPP YYLKKDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPHHYYS IIHHHRLLPP HHLKKDDDEL HHGWWWNCSC ------DDDD PPPDYATVDI DDPSPQQYYC IIHHHRLLPP NNLRRDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPQQYYC IIHHHRLLPP HHLKKDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPQQYYC IIHHHRLLPP NNLKKDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPQQYYC IIEEE----- ---------- ---------- ---------- PPPDYATVDV DDPSPQQYYC IIHHHRLLPP NNLKKDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPQQYYC IIHHHRLLPP NNLKKDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPQQYYS IIHHHRLLPP YYLKKDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPQQYYC IIHHHRLLPP NNLKKDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPQQYYC IIHHHRLLPP NNLKKDDDEL HHGWWWNCSC ------DDDD LLLDYATVDL DDPSPTTYYS IIHHHRLLPI HHIGGDDDKL HHGWWWNCSC ------DDDD ---------- ---------- ---------P NNTNNDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPSSYYS IIHHHRLLPP NNVNNDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPTTYYS IIHHHRLLPP YYVGGDDDEL HHGWWWNCSC ------DDDD PPPDYATVDL DDPSPTTYYS IIHHHRLLPP YYVGGDDDEL HHGWWWNCSC ------DDDD ---------- ---------- ---------P FFVGGDDDEL HHGWWWNCSC ------DDDD PPPDYATVDV DDPSPSSYYS IIHHHRLLPP FFVGGDDDEL HHGWWWNCSC ------DDDD PPPDYGTVDV DDPSPTTYYS IIHHHRLLPT HHVGGDDDEL HHGWWWNCSC ------DDDD PPPDAFTVDV NNPSDTTFFC IISSSRVVDP HHIGGDDDEV HHGWWWNCSC ------KKKK PPPDAFTVNV NNPSETTFFC IISSSRVVDP NNIGGDDDEV HHGWWWNCSC ------KKKK ---------- ---------- ---------- ---------- ---------- ---------- GGGDYATVDV DDPSPTTYYC IIHHHRTTYN SSKHHNNNEL HHGWWWNCSC HHFFPPKKKK GGGDYSTVDV DDPSPTTYYC VVHHHRTTFN RRKGGDDDEL HHGWWWNCSC YYYYDDKKKK IIITDKNPRM VVGVFLLGGG LLKKKDGGPK VVLEEDDDKE LLQPPPTRIK ------KKKK QQQDKVTIDL RRPSATTRRG IINNNSVVSG GG-RRNNNEA HHGFFFS--- ---------- QQQDKVTVDA NNPSPQQYYG VVNNNTLLSG GG-RRNNNEA HHDFFFT--- ---------- PNNIERFFVG GRSRRIDTKP NRRRRREEIK KIEEEEKVVV VSGGGYYHHG PDIYYAGNEE PFFLERYYVA ARSRRIDTKP DRRRRRRRVK KVEEVVVRRR RTGGGYYHHG PDIYYAGGPP AFFLERFFIG GRSRRVDTKP HTTTTTQQIK KIEDEELKKK KTGGGYYHHG PEIYYTGGAA AFFIERYYIG GRSRRIDTKP DTTTTTKKIK KIEEEEFKKK KTGGGYYHHG PDIYYTGGGG AFFLERYYIG GRSRRIDVK- ELLLLLKKIK KIEEEEFKKK KTGGGYYHHG PEIYYTGGGG PHHMERYYVG GRSRRIDTKP DLLLLLKKLK KIEETTARRR RTGGGYYHHG PGIYYAGNAA PHHVERYYVD DRSHHIDTKP DTTTTTQQVK KIDNEEARRR RTGGGYYHHG PDIYYAGSPP PHHVERYYVG GRSRRIDTKP DRRRRREEIK KIEEEEHRRR RTGGGYYHHG PDVYYAGSPP STTKSNKKLG GMSRRVDVGS ERRRRRAALK KIESEEQKKK KCNNNVVHHL ASEVVNLGDD STTKSDKKLS SISRRVDVGS ERRRRRAALK KIENEEHKKK KCNNNLLHHL ASEVVSLGDD STTKSTKKLC CMSRRVDVGS DRRRRRAALK KIEEDDHKKK KCGGGLLHHL ASEVVSLGDD ITTKATKKLA AISRRVDVGT ERRRRRAALK KIEKDDHKKK KCNNNLLHHL PSEVVSLGDD STTKSTKKLS SISRRVDVGS ERRRRRAALK KIEEDDHKKK KCEEELLHHL ASEVVSLGDD ---------- ---------- ---------- ---KDDHKKK KCEEELLHHL ASEVVSLGDD STTKSTKKLS SISRRVDVGS ERRRRRAALK KIEKDDHKKK KCEEELLHHL ASEVVSLGDD STTKSTKKLS SISRRVDVGS ERRRRRAALK KIEKDDHKKK KCEEELLHHL ASEVVSLGDD STTKSNKKLS SISRRVDVGT ERRRRRAALK KIEKDDHKKK KCGGGLLHHL PTEVVSLGDD STTKSTKKLS S--------- ---------- ---------- ---------- ---------- STTKSTKKLS SISRRVDVGS ERRRRRAALK KIEKDDHKKK KCEEELLHHL ASEVVSLGDD PSSAKRFFLS SLSRRVDTAT DRRRRRTTLK KVEEDDANNN NIGGGLLHHL ASDIISLGDD ASSKVNKKLC CISRRVDVGT DRRRRRAAIK KVEYEEFKKK KCGGGLLHHL GCEIISIGDD SSSKVNKKLC CISRRVDVGS DRRRRRAAIK KVEYEEFKKK KCGGGLLHHL GCEIISLGDD PSSAERFFAS SVSRRVDTKT NRRRRRSSLK KVDADDIKKK KTGGGLLHHL ASELLSLGDD PSSAQRFFVG GVSRRVDTKT NRRRRRAALK KVEEDDSKKK KTGGGLLHHL ASEIISIGDD ASSADRYYLS SISRRADTKE NRRRRRAALK KVDKEEAKKK KTGGGLLHHL ASEIISLGDD ASSVDRYYLS SISRRADTKE NRRRRRAALK KVDKEEAKKK KTGGGLLHHR T-EIISLGDD PSSASRFFLS SLSRRVDTLK DRRRRRAALK KVEEDDAKKK KTGGGLLHHL ASEIISLGDD PTTEKSHHVC CNSRRINVEN ERRRRRKKLH HIESKKHLLL LN---LLHHL ADNIISLGEE PTTEKSHHVC CNSRRVNVEN ERRRRREELH HIESKKHLLL LN---LLHHL ADNIISLGEE --------PK KSSVVKFVGG ---------- ---------- ---------- ---------- EVVPTDRRLC CNSRRVDTGT DRRRRRAALK KIE-DDLGGG GADDDCCHHL PNNIISMGDD TVVPKDRRLS SNSFFIDVVT DRRRRRKKIK KID-DDLSSS SHNNNVVHHL ANNIISMGDD RVVQGPQQQS SDGRRVTSLY SWWWWWDDFP P---DDIFFF FLVVVLLHHQ PNALLDVNEE ----DRFFTG GDTRRIDVHS DSSSSSNNLK KID-FFKSSS SGGGGVVHHL PGMMMGSNDD ----DRYYAG GDTKKVDVHS DAAAAARRLK KIT-FFESSS SGGGGVVHHL PGMLLGSNNN ----EGG--E EPPIIMMLLD DHHSSFFELL KWEIIIIDRR RGGGDQ---- -------LAF ----DGGRRE EPPIILLLLD DHHTTFFEII RWEVVVVYRR RGGGPQ---- -------FAF GGKKDGGTTD DAAIIIIMMD DCCTTFFDLL RWEIIIIDRR RGGGPQ---- -------KHF GGKKDGGTTN NPPVVIIMMD DCCTTFFELL RWEIIIIDRR RGGGPQ---- -------LHF GGEEDGGTTD DPPIIIILLD DCCTTFFELL RYEMMMMDRR RGGGEQ---- -------KHF ----EGG--K KPPIIMMLLD DAASSFFELL RWEVVVVERR RGGGPQ---- -------FAG ----EGG--E EPPIIIILLD DHHNNLLELL RWEIIIIDRR RGGGDQ---- -------LHF ----EGG--D DPPVVVVMMD DHHSSFFDLL RWEVVVVERR RGGGPQ---- -------LAF ----LQQGGN NKKFFLLLLD DGGTTFFEKK TWEKKKKPGG GGGGAS---- -------MGF ----PQQGGN NKKFFLLLLD DGGTTFFEKK TWEKKKKPGG GGGGEA---- -------MGF ----SKKGGN NKKFFLLLLD DGGTTFFEKK TWEQQQQPGG GGGGAA---- -------MGF ----PEEGGN NKKFFLLLLD DGGTTFFEKK TWEQQQQPGG GGGGAA---- -------LGF ----VKKGGN NKKFFLLLLD DGGTTFFEKK TWERRRRPGG GGGGAA---- -------SGF ----VKKGGN NKKFFLLLLD DGGTTFFEKK TWERRRRPGG GGGGAA---- -------LGF ----VKKGGN NKKFFLLLLD DGGTTFFEKK TWERRRRPGG GGGGAA---- -------LGF ----VKKGGN NKKFFLLLLD DGGTTFFEKK TWERRRRPGG GGGGAA---- -------LGF ----PKKGGN NKKFFLLLLD DGGTTFFEKK TWERRRRPGG GGGGSA---- -------MGF ---------- ---------- ---------- ---------- ---------- ---------- ----VKKGGN NKKSSVVLLL LPPRRLLESS ---------- ---------- ---------- ----KEEGGN NAAGGLLLLL LDDEEFFNKK RGSNNNNRLL LFFFPI---- -------KEH ----PYYGGN NKKFFLLLLD DGGTTFFEKK NWEAAAAEGG GEEEAA---- -------FGF ----PCCGGN NKKFFLLLLD DGGTTFFEKK NWEVVVVEGG GEEESA---- -------FGF ----KDDGGN NEEGGLLLLL LDDDDFFNKK RWEKKKKPGG GHHHSP---- -------FGF ----KDDGGN NEEGGLLLLL LDDEEFFNKK RWEKKKKPGG GHHHSP---- -------FGF ----EEEGGN NKKGGLLLLL LDDDDFFNKK RWEKKKKPGG GHHHSP---- -------FGF ----EEEGGN NKKGGLLLLL LDDDDFFNKK RWEKKKKPDD DIIISP---- -------YGF ----KEEGGN NAAGGLLLLL LDDEEFFNKK RWEKKKKPGG GHHHSP---- -------FGY ----ANNGGT TSSFFLLLLD DGGTTFFEKK TWPAAAADEE EKKKTV---- -------FNF ----ADDGGS SSSFFLLLLD DGGTTFFEKK TWPAAAADGG GKKKVV---- -------FNF ---------- ---------- ---------- ---------- ---------- ---------- ----AEEGGN NKKDDVVEEF FDDNNFFEVV TWSRRRRGDD DRRRKA---- -------CGY ----AEEGGY YKKDDIILLF FDDDDFFNII TWTKKKKGDD DKKKKA---- -------CGF ----SLLSSV VVVGGQQTTS SKKEENNGSS KGEAAAASQQ QFFFEE---- -------LQN ----DDDHHG GRRLLEEYYN NDDGGEEYAA YWMPPPPTAA ADDDDMGAVA AAAADDGYGI ----KDDHHG GRRLLEEYYT TNNGGEEYAA HWIPPPPTDD DGGGDLGAIK KAAADDGYDV WW---PPPNE EVLLLSSWVV ----TIE-KL LLEK--GNIH HHDLLRKRIS LTTTLGEEER WW---PPPSG GVMMMTSWVV ----CFE-SL LLEKGGGNLH HHDLLAKHLA IDDDLGQQER WW---PPPRD DYMMMSSWLL ----QFE-VP PPELNNGHLH HHDLLRANVT IDDDLGAAQQ WW---PPPRD DYMMMTSWLL ----QFE-VP PPELNNGHLH HHDLLRANVT IDDDLGAANQ WW---PPPRD DYMMMSSWLL ----QFE-VP PPELNNGHIH HHKLLRDNVT IDDDLGAANQ WW---GGGYD DTLLLTSWTT ----MVE-VP PPDLAAGRLH HHDLLTRHLE IDDDFGDDEQ WW---GGGYD DTLLLTSWTT ----MVE-LG GGDLGGGHLH HHDLLYRHLT LDDDLGAAEQ WW---GGGYD DTMMMTSWTT ----MIE-DP PPQLKKGRLH HHDLLRRHLA LDDDVGEEEQ YY---RRRHN NVMMMSTWAA ----VFKFPA AAHAGGGSIF FFDWWQRIIT LQQQMT---G YY---RRRHN NIMMMSTWAA ----VFKFPA AAHAGGGSIH HHDWWQRIIT LQQQMK---G YY---RRRHN NVMMMSTWAA ----VFRFPA AADAGGGSLH HHDWWQRIIT LTTTLQ---G YY---RRRHN NVMMMSTWAA ----VLRFPA AADAGGGSLY YYDWWQRIVT LPPPLQ---G YY---RRRHN NVMMMSTWAA ----VLRFPA AADAGGGSLY YYDWWQHIVT LSSSLK---G YY---RRRHN NVMMMSTWAA ----VLRFPA AADAGGGSLY YYDWWQRIVT LSSSLK---G YY---RRRHN NVMMMSTWAA ----VLRFPA AADAGGGSLY YYDWWQRIVT LSSSLK---G YY---RRRHN NVMMMSTWAA ----VLRFPA AADAGGGSLY YYDWWQRIVT LSSSLK---G YY---RRRHN NVMMMSTWAA ----VVQFPA AADAGGGKLH HHDWWQRIVT LLLLMP---G ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------ASHH ----LRLSDY YYPASSAGT- ---------- ---------- YYYYYAAAWG GLFFFSWQCC ----FYTALM MMCASSHVSC CCNYYIMIDS LPPPLQ---Q YY---RRRHN NVMMMSTWAA ----AFAFME EEEAGGGHLN NNDWWTERIT IDDDLGEE-G YY---RRRHN NVMMMSTWAA ----AFAFME EEDAGGGHLN NNDWWTELVT IDDDLGKK-G YY---RRRHN NTMMMSTWAA ----AFTFLQ QQHDGGGRLT TTQLLARLRT LDDDLGNN-G YY---RRRHN NTMMMSTWAA ----AFLFLQ QQHDGGGRLH HHSWWPGIKT LDDDLGDD-G YY---RRRHK KTMMMSTWAA ----AFSFLQ QQHDGGGSLH HHSWWPGMKL IDDDLGEE-G YY---RRRHK KTMMMSTWAA ----AFSFLQ QQHDGGGSLH HHSWWPGIKL IDDDLGPP-G YY---RRRHK KTMMMSSWAA ----AFRFLQ QQHDGGGRLH HHDWWPGLKT LDDDLGSS-G YY---RRRRN NVMMMSTWSS ----HIKFPA AAHEGGGNVH HHEWWDSYLT IDDDLPQQPG YY---RRRRN NIMMMSTWSS ----HIKFPA AAHEGGGNVH HHEWWDTHLT IDDDLPMMPG ---------- -----SIRGG ----TVCELK KKCEPPIKKR RR-------- ---------- YY---HHHFN NVMMMASWAA ----LFRYPT TTDDTTGCLN NNRWWQELFT IDDDLGDD-G YY---YYYFD DVMMMSSWAA ----KWRWNV VVDDSSGCLN NNKWWSTLYT IDDDLGSS-G NN------RE EKSSSSDPEE ----MAFSSF FFLTPPPQVA AAL------- ---------- AA---RRRKN NVMMMTSFGG NNYYMMDQLQ QQDAKKGNIV VVDLLHTPKV FNNNVPGGA- AA---RRRKN NLLLLTSFGG NNYYMMDKLA AADAKKGNVV VVDLLHTPKV FDDDVPGGA- M-----ERPP PLDDPTKKFN MVVLKKDLSS SWFFEDWNAA EKKVIIIAEE EEEPGG-NNL M-----ERPP PLDDPTKKFN VLLTKKDLSS SWFFEDWQAA ERRVIIIAQQ QQQPGG-PPL M-----ERPP PADDPVRRFG VVVTTTNLGG SWWWEGFHVV KKKTAIIAEE EEEPAADEEL M-----ERPP PADDPVRRFG VVVTTTNLAA SWWWEGFHAA EKKTAIIPEE EEEPKKEKKL M-----ERPP PADDPSKKFG VVVTTTNLGG AWWWDDFEAA KKKTIIIPVV VVVPAADDDL L-----ERPP PADDPTKKFN CIILKKDLSS SWYYDKWAVV RKKVIIIAEE EEEAPPDQQL M-----ERPP PADDPTKKFN CVVLKKDLAA SWYYDNWHLL KKKVIIIAEE EEEPEEDQQL M-----ERPP PADDPARRFG VVVLEEDLAA SWHHQNWGII RKKVIIIAEE EEEPPPDQQL L---LLERFF FLDDPSAAFG CLLSNNIQFF YEGG------ ----TSSEKK KKKVVVPSSK L---LLERFF FLDDPDAAFG CLLSNNIQFF YGGG------ ----TSSEKK KKKVVVPSSK L---LLERFF FLNNPDAAFG CLLSTTIQFF YGGG------ ----TSSEKK KKKVVVPPPK L---LLERFF FLNNPDAAFG CLLSTTIQFF FDGG------ ----TSSQKK KKKVVVPPPK L---LLERFF FLNNPDAAFG CLLSTTIQFF YGGG------ ----TSSEKK KKKVVVPPPK L---LLERFF FLNNPDAAFG CLLSTTIQFF YGGG------ ----TSSEKK KKKVVVPPPK L---LLERFF FLNNPDAAFG CLLSTTIQFF YGGG------ ----TSSEKK KKKVVVPPPK L---LLERFF FLNNPDAAFG CLLSTTIQFF YGGG------ ----TSSEKK KKKVVVPPPK H---LLERFF FLDDPAAAFG CLLSTTIQFF YGGG------ ----TSSEKK KKKVVVPPPK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ANNPLLCRSS SIWWKNIIYV VVVFSSGRGG SAYY------ ----AVVKRR RRRKLLYYYA L---LLERFF FLDDPDAALG CLLSTTVFFF YDGG------ ----KAAEKK KKKVVVPSSK L---LLERFF FLNNPDAALG CLLSSSIFFF YDGG------ ----KAAEKK KKKVVVPSSK L---LLERFF FLDDPAKKFG SLLSNNMIFF FDGG------ ----SSSELL LLLAVVKPPL L---LLERFF FLDDPAKKFG SLLSNNMIFF FDGG------ ----SNNEII IIIVVVEPPL L---LLERFF FLDDPSKKYG SLLSNNMIFF FDDD------ ----TSSEII IIIVVVKPPL L---LLERFF FLDDPSKKFG SLLSNNMIFF FDEE------ ----TSSEVV VVVVVVKPPL L---LLERFF FLDDPSKKYG CLLSNNMVFF FDGG------ ----SSSEVV VVVAIIKPPL A---LLERFF FLEEPTSSFG CLLSGGIFII HENN------ -TT-TAATLL LLLVIIPSSK A---LLERFF FLEEPTSSFG CLLSAAIFII HKNN------ -KK-VTTSLL LLLVIIPSSK ---------- ---------- ---------- ---------- ---------- ---------- L---LLERFF FLNNPREEYG CFFXXXXXXX X--------- ---------- ---------- I---LLERFF FLNNPKKKFG CLLAKKVFFF KDSS------ -EEFEKKVII IIIDGGKLLV ---------- ---------- ---------- ---------- ---------- ---------- ----LLERFF FPGGSNAAFT TLLSQQLWII YAGG------ ---------- ----WWQAAK ----LLERCC CAGGEAHHFS TLLSQQLWII YEGG------ ---------- ----WWQAAK LPEEKKKPFK IIILDDDKKF SSWGGGGVVR RRRYDDISSP KVVLTVKKLL GIFDP----- LPPPKKKDFK IIILDDDRRF SSWGGGGLLR RRRYDDITTP QRRLAVKKII GLYPP----- LPPPQQQGFG IILLDDDRRF SSWGGGGMMR RRRYDDVSSP NVVLAVRRII GIAPP----- LPPPQQQGFG IILMDDDRRF SSWGGGGMMR RRRYDDVSSP KKKLAVHHII GIAPP----- LPDDKKKGFG IILLDDDKKY AAWGGGGMMH HHHYDDVSSP NVVLTVEEII GIVPP----- LPPPKKKGFK IILMDDDRRF SSWGGGGLLL LLLYDDVSSP EKKLTVRRII GIVTPG---- LPPPKKKPFK IILVDDDRRF SSWGGGGLLH HHHYDDVSSP NRRLTVQQII GIVGP----- LPPPKKKDFG IILLDDDRRF SSWGGGGLLR RRRYDDVSSP NRRHTVRRLL GIVAP----- KKVVWWWMLP IILLDDDRRF SSWLGGGIIR RRRYDDISSP KRRLTIFFLL GSIGVQVVLE KKVVWWWMLP IILLDDDRRF SSWLGGGIIR RRRYDDISSP KRRLTIFFLL GSIGVQVVLE KKVVWWWMLP IILLDDDRRF SSWLGGGLLR RRRYDDISSP RRRLTLFFLL GSIGVQVVLE KKVVWWWMLP IILLDDDHHF SSWLGGGIIR RRRYDDVSSP RRRLTLFFLL GSIGVQVVLD KKVVWWWLLP IILLDDDRRF SSWLGGGLLR RRRYDDISSP RRRLTLFFLL GSIGVQVVLE KKVVWWWLLP IILLDDDRRF SSWLGGGLLR RRRYDDISSP RRRL------ ---------- KKVVWWWLLP ---------- ---------- ---------- ---------- ---------- KKVVWWWLLP IILLDDDRRF SSWLGGGLLR RRRYDDISSP RRRLTLFFLL GSIGVQVVLE KKVVWWWMLP IILLDDDRRF NNWLGGGMMR RRRYDDISSP RRRLVIFFLL GSIGVQVVLE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AVVVFFFGVV AAIFSSDLLL LL-------- ---------- ---------- ---------- KKVVWWWALP IIILDDDRRF SSWLGGGIIR RRRYDDITTP NKKLVIFFLL GSIGVTVVLE KKVVWWWPMP IIILDDDRRF SSWLGGGIIR RRRYDDITTT NKKLVIFFLL GSIGVTVVLE LKVVWWWILP FFILDDDRRF VVWLGGGIIR RRRYNNIEEL NVVLTLWWVV GLISVAAAIG LKVVWWWFLP FFILDDDRRF VVWLGGGIIR RRRYNNIEEV NKKLTVWWAA GLISVVAAVK LKVVWWWILP FFILDDDRRF VVWLGGGIIR RRRYNNIEEP NVVLTIWWVV GLLSVKAAVG LKVVWWWILP FFILDDDRRF VVWLGGGIIR RRRYNNIEEP NVVLTIWWVV GLLSVKAAVG LKVVWWWILP FFILDDDRRY VVWLGGGIIR RRRYNNIEEP KVVLAVWWAA GLLSVVYYVT KKVVWWWALP IIIMDDDRRF SSWLGGGIIR RRRYDDISSP KKKLNVYYII GSVSVKVVLE KKVVWWWALP IIIMDDDRRF SSWLGGGIIR RRRYDDISSP NKKLNVFFII GSITVKVVLE ---------- ---------- ---------- ---------- ---------- ---------- -QGGGGGEIE IIILDDDRRY SSWRGGGVVR RRRYDDISSR NRRLTVFFLL GAIARRVVLN VDTTGGGVAE IIILDDDRRF NNWRGGGVVR RRRYDDITTP NKKLTLFFLL GAILNVIIVK ---------- ---------- ---------- ---------- ---------- ---------- KAVVIIIGNP IIIADDDQQT NNFMGGGTTR RRRFDDISSP KFFQIKVVII RQV------- KAVVIIIGEP IIINDDDSSR NNFMGGGTTR RRRFDDISSP HRRQVKTTII AQV------- ---------- ---AGKKAML LEEIISRRDG RYNYSSTTWD DNNNQFFFFP EGLLKGWVKK ---------- ---SGEEAMI ISSVVSRRDG RYNYSSSSWN NNNNQFFFFP -GLLRGWAKK ---------- ---NGTTGMV VEEIISRRDG RYNYSSTTWD DDDDQFFFFP DGVVPAAVLL ---------- ---NGAAGMV VEEIISRRDG RYNYSSTTWD DDDDQFFFFP DGVVPGVVMM ---------- ---NGTTGMV VEEIISRRDG RYNYSSTTWD DEEEQFFFFP GDRRGAAVMM ---------- ---KNAAGMV VEEIISRRDG RYNYGGAAVD DPPPQFFFFP EGIIDGWVKK ---------- ---TSEEGMV VEEIISRRDG RYNYRRAAWD DEEEQFFFFP DGIIKGWVKK ---------- ---ASPPGMV VEEVVSRRDG RYNYAASSWD DEEEQFFFFP VGIIRGWAKK E-DQQELCEP PPLKGRRGMI IQQLLSLLDG RYTYSSDDWD DKKKQFFFF- PDLLIRESVV E-DQQELCEP PPLKGRRGMI IQQLLSLLDG RYTYSSAAWD DKKKQFFFF- PNLLIRESVV E-DQQELSEP PPLKGKKGMI IQQLLSLLDG RYTYSSAAWD DKKKQFFFF- PDLLIRESVV D-DQQELSEP PPLKGQQGMI IQQLLSLLDG RYTYSSAAWD DKKKQFFFF- PDLLIRESVV E-DQQELSEP PPLKGRRGMI IQQLLSLLDG RYTYSSAAWD DKKKQFFFF- PDLLIRESVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- E-DEEELSEP PPLKGRRGMI IQQLLSLLDG RYTYSSAAWD DKKKQFFFF- PDLLIRESVV E-DQQELSEP PPLKGRRGMI IQQLLSLLDG RYTYSSDDWD DKKKQFFFF- PDLLIRESVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- E-DKKDLCDP PPVKGKKGMI IQQLLSLLDG RYNYSSKKWD DKKKQFFFF- PDMMIKESVV E-DKKELCDP PPVKGIIGMI IQQLLSLLDG RYSYSSIIWD DKKKQFFFF- PDLLLKEAVV G-EDDGKWDV VVPQGKKGMI IQQLLTLLDG RYNFSSAAWD DKKKQFFFF- PGLLVEKSHH K-DDDGEWDV VVPQGKKGMI IQQLLSLLDG RYNFSSAAWD DKKKQFFFF- PKLLVEQSHH G-EDDGNFDV VVPKGSSGMI IQQLLSLLDG RYNFSSAAWD DRRRQFFFF- PELLMDKSHH G-EDDGNFEV VVPKGSSGMI IQQLLSLLDG RYNFSSAAWV VVVVSFFFF- PEIIMEKSHH T-EDDDKESV VVPKGRRGMI IQQLLSLLDG RYNFSSRRWD DEEEQFFFFG QDLLVKKSHH E-GEEK--EA AALKGKKGML LQQLLSLLDG RYTYKKKKWD DDDDQFFFF- PEHHVKSATT E-EDDHD-PA AALKGQQGML LQQLLSLLDG RYTYKKKKWD DDDDQFFFF- PENNVRSATT ---------- -------GKI IQQLLSVVDG RYNYSSTTWD DKKKQFFFF- PNVVVKESVV N-DPPELEEP PPVKGRRGML LQQLLSLLDG RYSFSSPPWD DKKKQFFFF- PEMMVAAGTT KEDKKELEPA AARKGRRGML LQQLLSLLDG RYSYSSPPWD DKKKQFFFF- PKMMVSQGHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MV VSSQQSWWDG RYSLAANNWD D--------- -----KKKDD ---------- --------MV VSSSSSWWDG RYSLAANNWD D--------- -----KKKDD AANN--SGGL EEIIKFFVDF FFGGEE---- --RRSSHHQQ QRRLSSGGAS SSSSCYPP-- VVNN--EGGL EELLKFFVDF FFGGRR---- --RRAAHHQQ QRRLWWGGAS STSSCYPP-- AAGG--DGGL TTLLDYYVEF FFPPDDGG-- --RRAAHHQQ QRRLEEGGCS STSSCYPPVK VVGG--NGGL EELLKYYVSF FFPPDDGG-- --RRAAHHQQ QRRLEEGGCS STSSCYPPV- VVGG--NGGL TTLLKFFVDF FFPPAAGG-- --RRSSHHQQ QRRLEEGGCS STSSCYPPV- AAGG--NGGI EEFFPFFLEW WWPPKKGG-- --RRPPHHQQ QRRLQQGGCS SSSSCYPP-- VVNN--DGGM QQFFPFFVDF FFGGEE---- --RRVVHHQQ QRRLQQGGAS SSSSCFPP-- AADD--GGGL SSLLPFFTEV VVGGDDGG-- --RRPPHHQQ QRRLEEGGSS SSSSCYPP-- QQVVDVNGGL KKLLPFFVDF FFGGKKEEPG GGLLAAHHEE ERRYPPGGCS SSIII----- QQIIDVNGGL KKLLPFFVDF FFGGKKEEPG GGLLAAHHEE ERRYPPGGCS SSIII----- QQIIDVKGGL KKLLPFFVDF FFGGKKEEPG GGLLAAHHEE ERRYPPGGCS SSIIL----- QQIIDVKGGL TTLLPFFVDF FFGGKKEEPG GGLLAAHHEE ERRYPPGGCS SSIIL----- QQVVDVKGGL KKLLPFFVDF FFGGKKEEPG GGLLAAHHEE ERRYPPGGCS SSIII----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQVVDVKGGL KKLLPFFVDF FFGGKKEEPG GGLLAAHHEE ERRYPPGGCS SSIII----- QQIIDVKGGL KKLLPFFVDF FFGGKKEEPG GGLLAAHHEE ERRYPPGGCT TSIIL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQIIDVKGGL KKLLPFFVDF FFGGKKEEPG GGLLAAHHEE ERRYPPGGCS SSIIV----- QQIIDVKGGL KKLLPFFVDF FFGGKKEEPG GGLLAAHHEE ERRYPPGGCT TSIII----- QQIIDVKGGL KKIIPFFVDF FFGGAAEEPG GGLLAAHHEE ERRYPPGGCT TSIII----- QQIIDVNGGL KKIIPFFVDF FFGGAAEEPG GGLLAAHHEE ERRYPPGGCT TSIII----- QQIIDVKGGL SSIIPFFVDF FFGGDDEEPG GGLLAAHHEE ERRYPPGGCT TSIII----- QQIIDGKGGL TTIIPFFVDF FFGGDDEEPG GGLLAAHHEE ERRYPPGGCT TSIII----- QQIIDVKGGL SSIIPFFVDF FFGGAAEEPG GGLLAAHHEE ERRYPPGGCT TSIII----- QQVVNISKKM EEIIRFFIDF FFGGKKIIEG GGLLAAHHEE ERRYPPGGCT TSIII----- QQIIDVTHHM VVIIKFFIDF FFGGKKVVPG GGLLAAHHEE ERRYPPGGCT TSIII----- QQIIDVKGGL TTVVKFFVDF FFGGKKEEPG GGLLAAHHDD DRRFPPCGST TSIIA----- QQLLDINGGM KKLLEFFVDF FFGGGGEEPG GGLLPPHHEE ERR------- ---------- LLIIDVNGGI SSLLEFFVDF FFAANNEEPG GGLLPPHHEE ERRYPPGGCT TSIILANNA- ---------- ---------- ---------- ---------- ---------- ---------- QQYYLKWGGK EELLEFFVDF FFYYEELLGG GGRRAAHHII IRRFGGSSLY YS-------- QQFFLKWGGK EELLEFFIDF FFYYAAEEKG GGRRPPHHQQ QRRFGGARLY YAPPGDGGRL ------- ------- KRR---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LVVQRVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNAAKPPPSS SEEATCRAAG GGAAARLDDA PPRRRTTAAA LSLTSPRRKA AAYQEAAAAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- --MAGRRRSS gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- WWWTFFAIQQ LSSSPPRSES SSKGRKKTTR VLVISSAAAA KKQQQQQQQQ AQWWAWLPPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AER ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----GLGKE ---------- ---------- ---------- ---------- ---------- --LLLNSQGC ---------- ---------- ---------- ---------- ---------- ---------- AAAPTTPLNN RTTTPPHPNP PPLAPAASSP HVPTRLVVPP YYRRRRRPPP RPCCPHARHS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------MKRR ---------- ---------- ---------- ---------- ---------- ------MKRF ---------- ---------M AAIIVPFKKK RRDPPPPKKA MPPPPPELLA YVACCCLGTN ---------- ---------- --MMAKLKKK PPDPPPPRRA MPPPPPEIIA YVAAAALGTN ---------- ---------- ----MSMRRR PPDAPPPEEA MPPPAAEFFA YTLLLLLDF- ---------- ---------- ----MTMRRR PPDAPPPKKA MPPPAAEFFA YTLLLLLDF- ---------- ---------- ----MTLRRR PPDPAAAKKA MPPPVVELLA FTLMMMLDA- ---------- ---------- --MMATWKKK PPDPPPPRRA APPPPPEIIA YVAMMMFER- ---------- ---------- --MMVTWRRR PPDPPPPRRA VPPPAAELLA YVVRRRLMA- ---------- ---------- --MMASWRRR PPDPPPPKKA MPPPRRELLG YVALLLLGR- ---------- --------MT KKCCTK---- CCGTLLLEEM KPPPRREIIV YLPCCCINTE ---------- ---------- ---------- ---------- MPPPRREIIV YLPCCCINTE GKHGIAARRG GGLLLPAAHT QQCCGK---- CCGSLLLEEM KPPPRREIIV YLPCCCINTE ---------- ---------- ---------- ---------M KPPPRREIII YLPCCCINTE ---------- --------MT KKCCGN---- CCGTLLLEEM KPPPRREIIV YLPCCCINTE RAEGQSSQQP PPRRRPSSTT KKCCGN---- CCGTLLLEEM KPPPRREIIV YLPCCCINTE ---------- --------MT KKCCGN---- CCGTLLLEEM K--------- ---------E ---------- --------MT KKCCGN---- CCGTLLLEEM KPPPRREIIV YLPCCCINTE EEPGPWWSSG GGLLLWDDTT KKCCGD---- CCGTQQQEEM KPPPRREIIV YLPCCCINTE CLGFTEETTY YYTTTLTTST KKCCGN---- CCGTLLLEEM KPPPRREIIV YLPCCCINTE ---------- --------MT KKCCGN---- CCGTLLLEEM KPPPRREIIV YLPCCCINTE SLVLEGGAAV VVTTTAAANK TTCCCHTAAA KKGTLLLEEM EPPPRRELLV YVTCCCVGTN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A KKCCGS---- CCGSLLLDDM KPPPRREIIV YLPCCCISTN ----ATTDDH HHVVVVKKK- VVNNGCCKKK SSGSIIIEEM SPPPRRELLI YVTAAAVGTE ----GTTQQH HHVVVVKKVN QQQQGCCKKK SSGSLLLEEM SPPPRRELLI YVTAAAVGTE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --RRMLQVVV GGGTLLLAAM SPPPSSELLI YVTAAAVGTD ---------- --MMMAAANA AACCCGGAAA TTGTLLLEEM EPPPRRELLL YVTCCCVGTN ---------- -----MNNCL KKCCHG---- --GSAAADDI KPPPRREVVL FVTAAAP-ND ---------- -----M--CL KKCCHG---- --GSAAADDI KPPPRREVVL FVTAAAP-HD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M SSEESKCKKK CCGTLLLDDV RPPPVVELLL YVVCCCVNLE ---------- ---------- ---------- ---------M RPPPRRELLL YTVTTTVNLP ---------- ---------- ---------- --MT---DDL IDDDDDRLLY FSNWWWLDIY REFG-----A AAAAAAAALM GGLLPFRAAA FFAQPPPYYP KGGGQQEFFV YVWTTTLEGD FIVSHFFRRA AAVVVSAALL AAAAPAGVVV RRAAPPPYYK KGGGQQEYYV YVWTTTLEGD FFAVVVVDVN PPEETYSSKK KKHVEELLPY NNDDLLHHFG GNSSSSALC- --PPNG-KPP FFAVVVVDVD PPPPTYGGKK KKYLDDLLPY GGDDLLHHFG GNSSSSAYC- --PPNA-KPP AAAVIIIDVK PPSSTYGGKK KKHVTTMMPN GGDDFFHHFG GNSSSSSLS- --PPLTGHAA AAAVIIIDVK PPPPTYGGQQ QQHVTTMMPN GGDDFFHHFG GNSSSSALS- --PPLAGHAA GGAVVVVDVD PPEEKFGGQQ QQHLIIMMPN GGDDFFHHFG GNSSSSALS- --PPLTGHAA AAAVVVVDVD PPPPRYAASS SSGVAAMMPH GGDDLLHHFG GNSSSSCLC- --PPNAPHPP AACVVVVDVD SSSSTFGGQQ QQGTDDMMPY GGGGLLHHFG GNSSSSMLC- --PPNAPHPP AAGVLLLDLD PPGGTYAAQQ QQGVEEMMPN AADDLLHHFG GNSAAAALC- --PPYAPHPP YYATVVVDVD PPPPQYSSQQ QQHLPPMMPY KKDDLLHHSG GNSSSSC--- -----FGDSS YYATVVVDVD PPPPHYSSQQ QQHLPPMMPH KKDDLLHHSG GNSSSSC--- -----FGDSS YYATVVVDID PPPPQYCCQQ QQHLPPMMPN RRDDLLHHSG GNSSSSC--- -----FGDSS YYATVVVDVD PPPPQYCCQQ QQHLPPMMPH KKDDLLHHSG GNSSSSC--- -----YGDII YYATVVVDVD PPPPQYCCQQ QQHLPPMMPN KKDDLLHHSG GNSSSSC--- -----FGDSS YYATVVVDVD PPPPQYCCQQ QQE------- ---------- ---------- ---------- YYATVVVDVD PPPPQYCCQQ QQHLPPMMPN KKDDLLHHSG GNSSSSC--- -----FGDSS YYATVVVDVD PPPPQYCCQQ QQHLPPMMPN KKDDLLHHSG GNSSSSC--- -----FGDSS YYATVVVDVD PPPPQYSSQQ QQHLPPMMPY KKDDLLHHSG GNSSSSC--- -----FGDSS YYATVVVDVD PPPPQYCCQQ QQHLPPMMPN KKDDLLHHSG GNSSSSC--- -----FGDSS YYATVVVDVD PPPPQYCCQQ QQHLPPMMPN KKDDLLHHSG GNSSSSC--- -----FGDSS YYATVVVDLD PPPPTYSSQQ QQHLPPVVIH GGDDLLHHSG GNSSSSC--- -----HGDPP ---------- ---------- ------MMPN NNDDLLHHSG GNSSSSC--- -----YGDAA YYATVVVDVD PPPPSYSSQQ QQHLPPMMPN NNDDLLHHSG GNSSSSC--- -----YGDSS YYATVVVDVD PPPPTYSSKK KKHLPPVVPY GGDDLLHHTG GNSSSSC--- -----HGDPP YYATVVVDLD PPPPTYSSKK KKHLPPVVPY GGDDLLHHTG GNSSSSC--- -----HGDPP ---------- ---------- ------MMPF GGDDLLHHSG GNSSSSC--- -----HGDAA YYATVVVDVD PPPPSYSSSS SSHLPPMMPF GGDDLLHHSG GNSSSSC--- -----HGDAA YYGTVVVDVD PPPPTYSSQQ QQHLPPVVTH GGDDLLHHSG GNSSSSC--- -----HGDPP AAFTVVVDVN PPDDTFCCQQ QQSVDDVVPH GGDDVVHHTG GNSSSSC--- -----HDKPP AAFTVVVNVN PPEETFCCQQ QQSVDDVVPN GGDDVVHHTG GNSSSSC--- -----HDKPP ---------- ---------- ---------- ---------- ---------- ---------- YYATVVVDVD PPPPTYCCQQ QQHTYYTTNS HHNNLLHHSG GNSSSSCHFV VVPP-GGKEE YYSTVVVDVD PPPPTYCCQQ QQHTFFTTNR GGDDLLHHSG GNSSSSCYYV VVDDESSKTT DDKNPPPRMV GGFFLGGGSS SSKGPPVVKV EEDDEELDSQ QTILLLK--- ------GKRR KKVTIIIDLR PPAATRGGQQ QQNVSSVVGG RRNNAAHHGG GS-------- ---------- KKVTVVVDAN PPPPQYGGKK KKNLSSVVGG RRNNAAHHSD DT-------- ---------- NEERRFFLLI VPLLLLRSIY IIIDTKKKPN PREEPKIKVE EEVVVKGSLL LHHVCCCGPD FEERRYYLLI VPLLLLRSIY IVVDTKKKPD KRRRPAAKIE VVAAAGGTYY YHHVCCCGPD FEERRFFLLI IPLLLLRSIY VIIDTKKKPH PTQQARHKID EEIIIAGSPP PHHVCCCGPE FEERRYYLLI IPLLLLRSIY IIIDTKKKPD PTKKAKHKIE EEVVVKGSPP PHHICCCGPD FEERRYYLLI IPIIIIRSIY IVVDVKKK-E PLKKAKHKIE EEVVVAGSPP PHHICCCGPE HEERRYYLLV VPLLLLRSIY ILLDTKKKPD PLKKPFAKVE TTLLLEGSPP PHHVCCCGPG HEERRYYLLV VPIIIIRSIT ILLDTKKKPD PTQQPKVKVN EELLLEGAPP PHHVCCCGPD HEERRYYLLI VPIIIIRSIH IVVDTKKKPD PREEPRVKVE EELLLRGSPP PHHICCCGPD TSSNNKKLLI LPLLLLMSIY VVVDVGGGSE PRAAPKHKVS EEIIIANSTT THHSCCCLAS TSSDDKKLLI LPIIIIISIY VVVDVGGGSE PRAAPKHKVN EEIIIANGLL LHHSCCCLAS TSSTTKKLLM LPLLLLMSIY VVVDVGGGSD PRAAPKHKVE DDIIIAGGVV VHHSCCCLAS TAATTKKLLV LPLLLLISIY VVVDVGGGTE PRAAPKHKVK DDIIITNGFF FHHSCCCLPS TSSTTKKLLV LPLLLLISIY VVVDVGGGSE PRAAPKHKVE DDIIIAEALL LHHSCCCLAS ---------- ---------- ---------- ---------K DDIIIAEALL LHHSCCCLAS TSSTTKKLLV LPLLLLISIY VVVDVGGGSE PRAAPKHKVK DDIIIAEALL LHHSCCCLAS TSSTTKKLLV LPLLLLISIY VVVDVGGGSE PRAAPKHKVK DDIIIAEALL LHHSCCCLAS TSSNNKKLLV LPFFFFISIY VVVDVGGGTE PRAAPKHKVK DDIIIEGGPP PHHSCCCLPT TSSTTKKLLV LPLLLL---- ---------- ---------- ---------- ---------- TSSTTKKLLV LPLLLLISIY VVVDVGGGSE PRAAPKHKVK DDIIIAEALL LHHSCCCLAS SKKRRFFLLI LPLLLLLSVY VVVDTAAATD PRTTPSHKVE DDIIIEGGPP PHHSCCCLAS SVVNNKKLLI LPLLLLISIY VVVDVGGGTD PRAAPRHKTY EEVVVWGALL LHHSCCCLGC SVVNNKKLLI LPLLLLISIY VVVDVGGGSD PRAAPRHKTY EEVVVWGAPP PHHSCCCLGC SEERRFFLLI APLLLLVSIY VIIDTKKKTN PRSSPSHKVA DDIIIQGAPP PHHSCCCLAS SQQRRFFLLI VPIIIIVSVY VIIDTKKKTN PRAAPSHKVE DDIIITGAPP PHHSCCCLAS SDDRRYYLLV LPLLLLISIY AIIDTKKKEN PRAAPSYKYK EEIIIEGAPP PHHACCCLAS SDDRRYYLLV LPLLLLISIY AIIDTKKKEN PRAAPSYKYK EEIIIDGAPP PHHACCCRT- SSSRRFFLLI LPLLLLLSVY VVVDTLLLKD PRAAPAHKVE DDIIIEGGPP PHHSCCCLAS TKKSSHHLLI VPLLLLNSIY IIINVEEENE -RKKIYEHTS KKLLLS-SPP PHHSCCCLAD TKKSSHHLLI VPLLLLNSIY VIINVEEENE -REEIYQHTS KKLLLA-SPP PHHSCCCLAD -------MMV PRLLLLSSEG KVVFVGGGG- ---------- ---------- ---------- VTTDDRRLLV LPLLLLNSIF VIIDTGGGTD PRAAPKAKV- DDVVVKDTPP PHHTCCCLPN VKKDDRRLLV LPLLLLNSIY ILLDVVVVTD PRKKPEVKT- DDVVVKNTPP PHHTCCCLAN VGGPPQQMML QLLLLLDGLY VTTTSLLLYS AWDDKQYP-- DDLLLKVASS SHHAYYYQPN -DDRRFFFFW TGLLLLDTIF IFFDVHHHSD PSNNPKHKT- FFVVVDGVPP PHHFAAALPG -DDRRYYLLW AGLLLLDTIF VFFDVHHHSD PARRPVSKT- FFVVVKGVPP PHHLAAALPG IIIALLG--E GGGGGGMLDD YSFEPGGKKK WEEEIYY--- ------DWNL LPPNEVLSSS IIIALLG--E GGGGGGLLDD DTFEPGGRRR WEEEVYY--- ------DWNL LPPSGVMTSS IIVTLLGGKD GGPPGGIMDD ETFDVGGRRR WEEEIDD--- ------DWNL LPPRDYMSSS IIVTLLGGKN GGPPGGIMDD ETFEVGGRRR WEEEITT--- ------DWNL LPPRDYMTSS IIVTLLGGED GGPPGGILDD ETFEIGGRRR YEEEMTT--- ------DWNL LPPRDYMSSS IIVALLG--K GGGGGGMLDD QSFEPGGRRR WEEEVYY--- ------DWHL LGGYDTLTSS IIIALLG--E GGGGGGILDD DNLEVGGRRR WEEEIYY--- ------DWHL LGGYDTLTSS VVVALLG--D GGGGGGVMDD ESFDPGGRRR WEEEVQQ--- ------DWHL LGGYDTMTSS EEMNTTL--N GGGGSSLLDD ETFEVGGTTT WEEEKPP--- ------DWQP PRRHNVMSTT EEMSSSL--N GGGGGGLLDD ETFEVGGTTT WEEEKPP--- ------DWQP PRRHNIMSTT EEMSTTL--N GGGGGGLLDD ETFEVGGTTT WEEEQPP--- ------DWQP PRRHNVMSTT EEMSTTL--N GGGGGGLLDD KTFEVGGTTT WEEEQPP--- ------DWQP PRRHNVMSTT EEMSSSL--N GGGGGGLLDD ETFEVGGTTT WEEERPP--- ------DWQP PRRHNVMSTT EEMSSSL--N GGGGGGLLDD ETFEVGGTTT WEEERPP--- ------DWQP PRRHNVMSTT EEMSSSL--N GGGGGGLLDD ETFEVGGTTT WEEERPP--- ------DWQP PRRHNVMSTT EEMSSSL--N GGGGGGLLDD ETFEVGGTTT WEEERPP--- ------DWQP PRRHNVMSTT EEMSTTL--N GGGGGGLLDD ETFEVGGTTT WEEERPP--- ------DWQP PRRHNVMSTT ---------- ---------- ---------- ---------- ---------- ---------- EEMSSSL--N GGDDGGVLLL -RLECGG--- ---------- ---------- --------AA DDMSCCL--N AAGGNNLLLL SEFNVGGRRR GSSSNSS--- ------TLEN NAAWGLFSWW EEMSSSI--N GGGGGGLLDD ETFEVGGNNN WEEEAPP--- ------DWQP PRRHNVMSTT EEMSSSL--N GGGGGGLLDD ETFEVGGNNN WEEEVQQ--- ------DWQP PRRHNVMSTT EEMSCCL--N AAGGNNLLLL SDFNVGGRRR WEEEKLL--- ------DWQP PRRHNTMSTT EEMSCCI--N AAGGNNLLLL SEFNVGGRRR WEEEKLL--- ------DWQP PRRHNTMSTT EELSCCL--N AAGGNNLLLL SDFNINNRRR WEEEKLL--- ------DWQP PRRHKTMSTT EELSCCL--N AAGGNNLLLL SDFNINNRRR WEEEKLL--- ------HWQP PRRHKTMSTT EEMSCCL--N AAGGNNLLLL SEFNVGGRRR WEEEKLL--- ------DWQP PRRHKTMSSS NNMSTTL--T PPGGNNLLDD KTFEPGGTTT WPPPAPP--- ------DWQP PRRRNVMSTT NNMSTTL--S PPGGNNLLDD KTFEPGGTTT WPPPAPP--- ------DWQP PRRRNIMSTT ---------- ---------- ---------- ---------- ---------- -------SII NNMSIIM--N AAGG--VEFF KNFELGGTTT WSSSRLL--- ------DWQP PHHFNVMASS NNMSVVM--Y AAGG--ILFF SDFNCGGTTT WTTTKLL--- ------DWQP PYYFDVMSSS AAKDGGV--V PPLLNNQTSS HENGLAAKKK GEEEAII--- ------SHNG G--REKSSDD MMIGLLS--G GGTTAAEYNN DGEYVTTYYY WMMMPQQAVG AAADDGDRLI IRRKNVMTSS MMIGLLS--G GGTTAAEYTT AGEYVTTHHH WIIIPRRAIG AAADDGDRLP PRRKNLLTSS EWAAVP-TTT TTIDDGKLLE HLLKKD-RRR YGGRHHFFFW WWKRRKIIIH SSLTLGEEEE EWTTVP-CCC CCFEEGSLLE CLLKKEGAAA YGGKHHVVVW WWKRRRLLLY AAIDLGQQQE EWAALP-QQQ QQFNNGVPPE DLLLLANKKK YGGRHHFFFW WWARRRVVVQ TTIDLGAAAQ EWAALP-QQQ QQFNNGVPPE DLLLLSNKKK YGGRHHFFFW WWARRRVVVQ TTIDLGAAAN EWGGLP-QQQ QQFNNGVPPE DLLLLSNKKK YGGKHHFFFW WWDRRKVVVQ TTIDLGAAAN EWGGTP-MMM MMVDDGVPPD ILLLLGARRR YGGRHHFFFW WWRRRRLLLQ EEIDFGDDDE EWGGTP-MMM MMVSSGLGGD ELLLLAGKKK YGGRHHVVVW WWRRRRLLLQ TTLDLGAAAE EWGGTP-MMM MMIGGGDPPQ ILLLLNKGGG YGGRHHIIIW WWRRRRLLLQ AALDVGEEEE EWAAAP-VVV VVFDDGPAAH VEEAA-GLLL YGGRFFVVVW WWRHHEIIIQ TTLQMT---- EWAAAP-VVV VVFDDGPAAH VEEAA-GLLL YGGHHHVVVW WWRHHEIIIQ TTLQMK---- EWAAAP-VVV VVFDDGPAAD VEEAA-GLLL YGGHHHVVVW WWRHHEIIIQ TTLTLQ---- EWAAAP-VVV VVLDDGPAAD VKKAA-GLLL YGGHYYVVVW WWRRREVVVQ TTLPLQ---- EWAAAP-VVV VVLDDGPAAD VEEAA-GLLL YGGHYYVVVW WWHHHEVVVQ TTLSLK---- EWAAAP-VVV VVLDDGPAAD VEEAA-GLLL YGGHYYVVVW WWRHHEVVVQ TTLSLK---- EWAAAP-VVV VVLDDGPAAD VEEAA-GLLL YGGHYYVVVW WWRHHEVVVQ TTLSLK---- EWAAAP-VVV VVLDDGPAAD VEEAA-GLLL YGGHYYVVVW WWRHHEVVVQ TTLSLK---- EWAAAP-VVV VVVNNGPAAD VEEAA-GLLL YGGHHHVVVW WWRHHEVVVQ TTLLMP---- ---------- ---------- ---------- ---------- ---------- ---------- ISAAHS-LLL LLRTTGDYYP ASSAA-SRRR VAAI------ ---------- ---------- IQCCCS-FFF FFYTTGLMMC LTTAA-SGGG VHHICCLLLD DDMRRVDDDE SSLPLQ---- EWGGAP-AAA AAFLLGMEEE VQQAA-GMMM YGGSNNVVVW WWEHHRIIIQ TTIDLGEEE- EWGGAP-AAA AAFLLGMEED VQQAA-GHHH YGGSNNVVVW WWEHHRVVVQ TTIDLGKKK- SWGGAP-AAA AAFKKGLQQH VAADD-GLLL YGGHTTCCCI IIRGGERRRQ TTLDLGNNN- SWGGAP-AAA AAFQQGLQQH VAADD-GLLL YGGHHHVVVY YYGGGEKKKQ TTLDLGDDD- SWGGAP-AAA AAFKKGLQQH VAADD-GLLL YGGHHHVVVY YYGGGEKKKQ LLIDLGEEE- SWGGAP-AAA AAFKKGLQQH VAADD-GLLL YGGHHHVVVY YYGGGEKKKQ LLIDLGPPP- SWGGAP-AAA AAFTTGLQQH VQQDD-GLLL YGGHHHVVVY YYGGGEKKKQ TTLDLGSSS- EWGGSP-HHH HHIKKGPAAH VGGEE-GLLL YGGSHHIIIF FFSKKKLLLQ TTIDLPQQQP EWGGSP-HHH HHIKKGPAAH VPPEE-GLLL YGGSHHIIIF FFTKKKLLLQ TTIDLPMMMP LRGGGP-TTT TTVRRDLKKC QPPEE-PLLL VIICRRVVVY YY-------- ---------- EWGGAP-LLL LLFRRGPTTD CDDDDRTQQQ YGGRNNFFFY YYERREFFFQ TTIDLGDDD- EWGGAP-KKK KKWRRGNVVD LEEDDMSQQQ YGGRNNFFFY YYTQQTYYYQ TTIDLGSSS- RPDDEP-MMM MMAEESSFFL KKKTTGPLLL KPPHAAEEEV VV-------- ---------- SFTTGWNMMM MMMFFGLQQD AEEAAMKRRR FGGTVVQQQW WWTRRQKKKK VVFNVPGGGA SFTTGWNMMM MMMFFGLAAD PEEAAMKHHH FGGTVVTTTW WWTKKQKKKK VVFDVPGGGA EENNRRMAAL -----ELLHP TKLLGFFINN MMVVDDSSSW WFYEDGWWEK IIEIPPAEEP EEHHRRMVVL -----EVVHP TKLLGFFVNN VVLLDDSSSW WFYEDGWWER IIDIEEAQQP QQHHQQMAAL -----EVVHP VREEGFFVGG VVVVNNGSSW WWREGGFFKK AATIPPAEEP NNHHQQMAAL -----EVVHP VREEGFFVGG VVVVNNASSW WWREGGFFEK AATIPPPEEP NNHHQQMAAL -----EIIHP SKDDGFFCGG VVVVNNGAAW WWQDDGFFKK IITIDDPVVP EEHHQQLVVF -----ELLHP TKAAGFFVNN CCIIDDSSSW WYRDKDWWRK IIEIPPAEEA EEYYQQMAAL -----ELLHP TKAAGFFMNN CCVVDDASSW WYRDNGWWKK IIDIPPAEEP EEHHQQMVVL -----ELLHP ARTTGFFVGG VVVVDDASSW WHRQNGWWRK IIEIPPAEEP --DDGGLIIP -----EIIHP SATTGFFVGG CCLLIIFYYE EG-------- TTWSVVEKKV --DDGGLIIP -----EIIHP DATTGFFVGG CCLLIIFYYG GG-------- TTWSVVEKKV --DDGGLIIP -----EIIHP DAAAGFFVGG CCLLIIFYYG GG-------- TTWSVVEKKV --DDGGLIIP -----EIIHP DAAAGFFVGG CCLLIIFFFD DG-------- TTWSAAQKKV --DDGGLIIP -----EIIHP DAAAGFFVGG CCLLIIFYYG GG-------- TTWSVVEKKV --DDGGLIIP -----EIIHP DAAAGFFVGG CCLLIIFYYG GG-------- TTWSVVEKKV --DDGGLIIP -----EIIHP DAAAGFFVGG CCLLIIFYYG GG-------- TTWSVVEKKV --DDGGLIIP -----EIIHP DAAAGFFVGG CCLLIIFYYG GG-------- TTWSVVEKKV --DDGGHIIP -----EIIHP AASSGFFVGG CCLLIIFYYG GG-------- TTWSVVEKKV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --DDQQAGGA NPPPICLLHK NINNDYYDVV VVVVGGGSSA AY-------- AAVVLLKRRK --DDGGLIIP -----EIIHP DAAAGLLVGG CCLLVVFYYD DG-------- KKWAAAEKKV --DDGGLIIP -----EIIHP DADDGLLVGG CCLLIIFYYD DG-------- KKWAAAEKKV --TTGGLLLP -----EIIHP AKDDGFFVGG SSLLMMFFFD DG-------- SSWSHHELLA --KKGGLLLP -----EIIHP AKDDGFFVGG SSLLMMFFFD DG-------- SSWNHHEIIV --TTGGLLLP -----EIIHP SKDDGYYVGG SSLLMMFFFD DD-------- TTWSYYEIIV --TTGGLLLP -----EIIHP SKDDGFFVGG SSLLMMFFFD DE-------- TTWSHHEVVV --TTGGLLLP -----EVVHP SKDDGYYVGG CCLLMMFFFD DG-------- SSWSHHEVVA PPLLGGALLP -----EVVHP TSEEAFFVGG CCLLIIIHHE ENS------T TTHAAATLLV PPRRGGALLP -----EVVHP TSEEAFFVGG CCLLIIIHHK KNP------K VVQTAASLLV ---------- ---------- ---------- ---------- ---------- ---------- --DDGGLTTP -----EIIHP RENNGYYVGG CCFFXXXXX- ---------- ---------- --DDGGITTP -----EIIHP KKAAGFFVGG CCLLVVFKKD DSD------E EEAKKKVIID ---------- ---------- ---------- ---------- ---------- ---------- AAPP------ -----EIIWS NANNAFFSTT TTLLLLIYYA AG-------- ---------- AAPP------ -----EIIWE AHNNCFFTSS TTLLLLIYYE EG-------- ---------- LEEG-NLPEE EEILKPPPFF KAPPDDIISL LDFLYYGIEE EVDDIISSFK KVVLTVKGGG FEEG-PLPPP PPVLKDDDFF KMPPDDIISL LDFLYYGLEE ELDDIITTHQ QRRLAVKGGG ATTADELPPP PPLLQGGGFF GAPPDDIISL LDFLYYGTEE EMDDVVSSHN NVVLAVRGGG APPKEKLPPP PPLLQGGGFF GAPPDDIISM MDFLYYGTEE EMDDVVSSRK KKKLAVHGGG ADDADDLPDD DDLLKGGGFF GAPPDDIISL LDYLYYGLEE EMDDVVSSMN NVVLTVEGGG ADDPDQLPPP PPVLKGGGFF KAPPDDIISM MDFLYYGTDD DLDDVVSSFE EKKLTVRGGG ASSEDQLPPP PPILKPPPFF KAPPDDIISV VDFLYYGTEE ELDDVVSSFN NRRLTVQGGG AEEPDQLPPP PPLLKDDDFF GAPPDDIISL LDFLYYGTEE ELDDVVSSFN NRRHTVRGGG IQQVPSKKVV VVKGWMMMLL PEPGDDIISL LDFLYYLHDD DIDDIISSQK KRRLTIFGGG IQQVPSKKVV VVKGWMMMLL PEPGDDIISL LDFLYYLHDD DIDDIISSKK KRRLTIFGGG IQQVPPKKVV VVKGWMMMLL PEPGDDIISL LDFLYYLHDD DLDDIISSQR RRRLTLFGGG IQQVPPKKVV VVKGWMMMLL PEPGDDIISL LDFLYYLHDD DIDDVVSSQR RRRLTLFGGG IQQVPPKKVV VVKGWLLLLL PEPGDDIISL LDFLYYLHDD DLDDIISSQR RRRLTLFGGG IQQVPPKKVV VVKGWLLLLL PEPGDDIISL LDFLYYLHDD DLDDIISSQR RRRL------ IQQVPPKKVV VVKGWLLLLL PEPG------ ---------- ---------- ---------- IQQVPPKKVV VVKGWLLLLL PEPGDDIISL LDFLYYLHDD DLDDIISSQR RRRLTLFGGG IEEVPPKKVV VVKGWMMMLL PEPGDDIISL LDFLYYLHDD DMDDIISSKR RRRLVIFGGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LDDLYYAVVV VVAKFGGGVV VSSNPPAAFF FSLIII---- ---------- ---------- IKKVPSKKVV VVEGWAAALL PEPGDDIISL LDFLYYLHDD DIDDIITTRN NKKLVIFGGG IQQVPSKKVV VVEGWPPPMM PEPGDDIISL LDFLYYLHDD DIDDIITTRN NKKLVIFGGG IPPVKPLKVV VVQNWIIILL PEPGDDFFSL LDFLYYLHDD DINNIIEEKN NVVLTLWGGG ISSVEPLKVV VVQNWFFFLL PEPGDDFFSL LDFLYYLHDD DINNIIEEKN NKKLTVWGGG ISSVKPLKVV VVENWIIILL PEPGDDFFSL LDFLYYLHDD DINNIIEEKN NVVLTIWGGG ISSVKPLKVV VVENWIIILL PEPGDDFFSL LDFIYYLHDD DINNIIEEKN NVVLTIWGGG ISSIKPLKVV VVRNWIIILL PEPGDDFFSL LDYLYYLHDD DINNIIEEAK KVVLAVWGGG AFFIPSKKVV VVSGWAAALL PEPADDIISM MDFLYYLHDD DIDDIISSLK KKKLNVYGGG ATTIPSKKVV VVENWAAALL PDPADDIISM MDFLYYLHDD DIDDIISSKN NKKLNVFGGG ---------- ---------- ---------- ---------- ---------- ---------- -------QGG GGENGEEEII EMGGDDIISL LDYLYYRHDD DVDDIISSAN NRRLTVFGGG IPPGKLVDTT TTGSGVVVAA EDGGDDIISL LDFLYYRHDD DVDDIITTEN NKKLTLFGGG ---------- ---------- ---------- ---------- ---------- ---------- -EEWQAKAVV VVADIGGGNN PAIPDDIIAA ADTLWWMDKK KTDDIISSHK KFFQIKVDDD -EEWQAKAVV VVADIGGGEE PAVPDDIISN NDRLWWMDKK KTDDIISSHH HRRQVKTGGG GIIIFDHPP- ---------- ------AHHK LGGAAQSRDD GVVVYVSYYS TTWQQQFPGL GLLLYPHPP- ---------- ------SAAE AGGAAQSRDD GVVVYISYYS SSWQQQFPGL GIIIAPHPP- ---------- ------NRRT FGGGGQSRDD GVVVYWSYYS TTWQQQFPGV GIIIAPHPP- ---------- ------NKKA FAAGGQSRDD GVVVYWSYYS TTWQQQFPGV GIIIVPHPP- ---------- ------NKKT FYYGGQSRDD GVVVYWSYYS TTWQQQFPDR GIIIVTHPPG ---------- ------KGGA LGGGGQSRDD GVVVYFSYYG AAVQQQFPGI GIIIVGHPP- ---------- ------TAAE LGGGGQSRDD GVVVYFSYYR AAWQQQFPGI GIIIVAHPP- ---------- ------AGGP LGGGGQSRDD GVVVYFSYYA SSWQQQFPGI GSSSIGSVVQ VV-DQQQEEL LTQQPVKKKR IGGGGQSLDD GLLLYASYYS DDWQQQF-DL GSSSIGSVVQ VV-DQQQEEL LTQQPVKKKR VGGGGQSLDD GLLLYVSYYS AAWQQQF-NL GSSSIGPVVQ VV-DQQQEEL LKQQPVKKKK VGGGGQSLDD GLLLYVSYYS AAWQQQF-DL GSSSIGPVVQ VV-DQQQEEL LDQQPVKKKQ VGGGGQSLDD GLLLYVSYYS AAWQQQF-DL GSSSIGPVVQ VV-DQQQEEL LKQQPVKKKR VGGGGQSLDD GLLLYISYYS AAWQQQF-DL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSSSIGPVVQ VV-DEEEEEL LKQQPVKKKR VGGGGQSLDD GLLLYISYYS AAWQQQF-DL GSSSIGPVVQ VV-DQQQEEL LKQQPVKKKR VGGGGQSLDD GIIIYVSYYS DDWQQQF-DL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GSSSIGPVVT VV-DKKKDDL LEQQPIKKKK VGGGGQSLDD GLLLYVSYYS KKWQQQF-DM GSSSIGPVVT VV-DKKKEEL LEQQPTKKKI IGGGGQSLDD GIIIYVSYYS IIWQQQF-DL GLLLISPVVA AA-EDDDGGK KTQQVEQQQK LGGGGQTLDD GLLLYVSFFS AAWQQQF-GL GLLLISPVVV AA-DDDDGGE ETQQVEQKKK LGGGGQSLDD GLLLYVSFFS AAWQQQF-KL GLLLLSPVVK AA-EDDDGGN NSQQVQKKKS LGGGGQSLDD GLLLYASFFS AAWQQQF-EL GLLLLSPVVK AA-EDDDGGN NTQQVQKKKS LGGGGQSLDD GLLLYASFFS AAWSSSF-EI GLLLLSEVVV YY-EDDDDDK KEQQVQKHHR LGGGGQSLDD GIIIYVSFFS RRWQQQFGDL GSSSVSNVVK VV-GEEEKK- --PPAYKRRK IGGGGQSLDD GLLLYVSYYK KKWQQQF-EH GSSSITTVVK VV-EDDDHHD D-EEAYKRRQ IGGGGQSLDD GLLLYVSYYK KKWQQQF-EN ---------- ---------- ---------- -GGGGASVDD GLLLYVSYYS TTWQQQF-NV GAAAIAPRRR VV-DPPPEEL LKAAPFKRRR LGGGGQSLDD GLLLYVSFFS PPWQQQF-EM GAAAILPNNV IIEDKKKEEL LKRRAYKRRR LGGGGQSLDD GLLLYVSYYS PPWQQQF-KM ---------- ---------- ---------- ---------- ---------- ---------- RQQQV----- ---------- ---------- ------SWDD GVVVYFSLLA NNW------- AQQQV----- ---------- ---------- ------SWDD GLLLYYSLLA NNW------- KKWWMVLNNN ------SGGL LLDDDKKEEE FFFFVV---- -AHQRLSSGG DASSSSDSYP RRWWMAVNNN ------EGGL LLEEEKKEEE FFFFVV---- -AHQRLWWGG DASSTTDSFP PPAAQVAHHG ------DGGL LLAAADDDDD YYWWVV---- -YHQRLEEGG DCSSTTDSFP PPVVEVANNG ------NGGL LLDDDKKDDD YYFFVV---- -YHQRLEEGG DCSSTTDSFP GGAAMVANNG ------NGGL LLDDDKKDDD FFWWVV---- -YHQRLEEGG DCSSTTDSFP DDWWMVLDDG ------NGGI IIDDDPPKKK FFFFLL---- -HHQRLQQGG DCSSSSDSYP KKWWMVVDDN ------DGGM MMDDDPPNNN FFFFVV---- -QHQRLQQGG DASSSSDSYP RRWWIAAEED ------GGGL LLDDDPPGGG FFFFTT---- -LHQRLEEGG DSSSSSDSYP IIEEGSMLLV DDVDDDNGGL LLNNNPPNNN FFLLVVPLGG PAHERYPPGG DCSSSSDIW- IIEEGSMLLI DDVDDDNGGL LLNNNPPNNN FFLLVVPLGG PAHERYPPGG DCSSSSDIW- IIEEGSMLLI DDVDDDKGGL LLNNNPPNNN FFLLVVPLGG PAHERYPPGG DCSSSSDIW- IIEEGSMLLI DDVDDDKGGL LLNNNPPNNN FFLLVVPLGG PAHERYPPGG DCSSSSDIW- IIEEGSMLLV DDVDDDKGGL LLNNNPPNNN FFLLVVPLGG PAHERYPPGG DCSSSSDIW- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIEEGSMLLV DDVDDDKGGL LLNNNPPNNN FFLLVVPLGG PAHERYPPGG DCSSSSDIW- IIEEGSMLLI DDVDDDKGGL LLNNNPPNNN FFLLVVPLGG PAHERYPPGG DCTTSSDIW- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIEEGSMLLI DDVDDDKGGL LLNNNPPNNN FFLLVVPGGG PVHERYPPGG DCSSSSDIW- LLEEGAMLLI DDVDDDKGGL LLNNNPPNNN FFLLVVPDGG PVHERYPPGG DCTTSSDIW- VVKKGSILLI DDVDDDKGGL LLNNNPPNNN FFFFVVPDGG PAHERYPPGG DCTTSSDIW- VVQQGSILLI DDVDDDNGGL LLNNNPPNNN FFFFVVPDGG PSHERYPPGG DCTTSSDIW- MMKKGSIIII DDVDDDKGGL LLNNNPPNNN FFFFVVPEGG PAHERYPPGG DCTTSSDIW- MMKKGSIIII DDGDDDKGGL LLNNNPPDDD FFFFVVPDGG PSHERYPPGG DCTTSSDIW- VVKKGSMLLI DDVDDDKGGL LLNNNPPNNN FFFFVVPEGG PSHERYPPGG DCTTSSDIW- VVSSGAMVVV NNIDDDSGKM MMNNNRRDDD FFLLIIEGGG PYHERYPPGG DCTTSSDIW- VVSSGAMLLI DDVDDDTGHM MMNNNKKNNN FFLLIIPGGG PYHERYPPGG DCTTSSDIW- VVEEGSMLLI DDVDDDKGGL LLNNNKKNNN FFLLVVPNGG PCHDRFPPCG DSTTSSDIL- VVAAGGIVVL DDIDDDNGGM MMNNNEENNN FFLLVVPYGG PGHER----- ---------- VVQQGGIVVI DDVDDDNGGI IINNNEEDDD FFLLVVPYGG PSHERYPPGG DCTTSSDIWN ---------- ---------- ---------- ---------- ---------- ---------- --KKGKDAAY LLKAAAWDGK KKVVVEEDDD FFAAVVGLGG --HIRFGGSS ALYYSSS--- --KKGKDEEF LLKLLLWDGK KKKKKEEQQQ FFAAIIKLGG --HQRFGGAR ALYYAAGPAG ------- ------- SSVK--- SSV---- SSV---- ------- ------- SS----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- DDA---- ------- ------- NNRLARV 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158SSAAAKKKKQ SEPRRTTTAT GGTALADDMM QSLPPPRTTA ASSLSSSPII KAAYEEEWWT gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---MGGGAAP gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FSAAASSSPS SSSKKKKTTR SVVPPGLISS VVKKQVVQQQ AAVVQWWHWW WLLLLLPPGG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------AERG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MGG GLLLLLGKEG ---------- ---------- ---------- ---------- -----LLKNN NSSSSSQGCF ---------- ---------- ---------- ---------- ---------- ---------- TPPPTTTTPP PPPLLAASSP PHHPPRVTLL RRYYRTIPPP PRLLPCCPHH HAAAAARHSL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMMMMKRRG ---------- ---------- ---------- ---------- ---------- -MMMMMKRFS ---------- ---------- -AVPRRTFFF YYPSSPPPKA KAPPLVCTTT INRAADDFFF ---------- ---------- --AKPPTFFF YYPTTPPPRA RAPPIVAVVV VNAPPDDFFF ---------- ---------- --MSPPTFFF HHASSPPPEA QAPPFTLPPP --RPPDDAAA ---------- ---------- --MTPPTFFF HHASSPPPKA EAPPFTLPPP --KPPDDAAA ---------- ---------- --MTPPTFFF YYPSSAAAKA EGPPLTMPPP --KPPDDGGG ---------- ---------- --ATPPSFFF YYPSSPPPRA KAPPIVMPPP --QPPDDAAA ---------- ---------- --VTPPTFFF YYPSSPPPRA KAPPLVRPPP G-KPPDDAAA ---------- ---------- --ASPPTFFF YYPSSPPPKA QAPPLVLPPP --RPPDDAAA ---------- ---------- -KTKCCGYYY PPTPPLLLEM -GPPILCRRR TEAPPDDYYY ---------- ---------- ---------- ---------- -GPPILCRRR IEAPPDDYYY AAAAAAAAVV LAPPPARGGP AQGKCCGYYY PPSPPLLLEM -GPPILCGGG IEAPPDDYYY ---------- ---------- ---------- ---------M -GPPILCRRR IEAPPDDYYY ---------- ---------- -KGNCCGYYY SSTPPLLLEM -GPPILCRRR TEAPPDDYYY AAAAAFFFTT LSVVVAQPPP SKGNCCGYYY SSTPPLLLEM -GPPILCRRR TEAPPDDYYY ---------- ---------- -KGNCCGYYY SSTPPLLLEM -G-------- TEAPPDDYYY ---------- ---------- -KGNCCGYYY SSTPPLLLEM -GPPILCRRR TEAPPDDYYY HHHHHTTTAA QWFFFLSGGW DKGDCCGYYY PPTPPQQQEM -GPPILCRRR TEAPPDDYYY DDDDDQQQTT NELLLHTYYL TKGNCCGYYY SSTPPLLLEM -GPPILCRRR TEAPPDDYYY ---------- ---------- -KGNCCGYYY SSTPPLLLEM -GPPILCRRR TEAPPDDYYY QQQQQHHHII MGAAAAAVVA ATCHKKGYYY AATPPLLLEM KGPPLVCNNN INKLLDDYYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -KGSCCGYYY KKSPPLLLDM -GPPILCRRR INKPPDDYYY ---------- MTVVVLDHHV KVGCSSGYYY AASPPIIIEM -GPPLVAAAA IEKPPDDYYY ---------- MTVVVLQHHV KQGCSSGYYY AASPPLLLEM -GPPLVAAAA IEKPPDDYYY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MLGGGYYY AATPPLLLAM -GPPLVATTT IDKPPDDYYY ---------- ---------A AACGTTGYYY AATPPLLLEM KGPPLVCNNN INKPPDDYYY ---------- ---------M NKHG--GYYY AASPPAAADI -GPPVVA--- ADGPPDDAAA ---------- ---------M -KHG--GYYY AASPPAAADI -GPPVVA--- RDGPPDDAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -SSKCCGYYY AATPPLLLDV NGPPLVCPPP EEHGGDDYYY ---------- ---------- ---------- ---------M SGPPLTTPPP EPHGGDDYYY ---------- ---------- ------GLLL IIT-----DL SLDDLSWGGG QYDIITTDDD ---------- -------AAA AGPFFFETTT CCQSSPPPYP ITGGFVTVVV GDEQQDDKKK GGGGGPPPSS MFAAALRAAS AAPARRETTT CCASSPPPYK ITGGYVTAAA GDEQQDDKKK IIAAVVVVVD VNPTYSSKII IVKVVELPYY EELHHHGGWN NACCCSSSSA ALPNNNGGNI LLAAVVVVVD VDPTYGGKVV VIKLLDLPYY EELHHHGGWN NACCCSSSSA AYPNNNAAFL LLAAVVVIID VKPTYGGKII IVTVVTMPNN EEFHHHGGWN NACCCSSSSS SLPLLLTTFL LLAAVVVIID VKPTYGGQII IVTVVTMPNN EEFHHHGGWN NACCCSSSSA ALPLLLAAFI LLAAVVVVVD VDPKFGGQII IVQLLIMPNN EEFHHHGGWN NACCCSSSSA ALPLLLTTFL IIAAVVVVVD VDPRYAASII IVQVVAMPHH EELHHHGGWN NACCCSSSSC CLPNNNAAHM MMCCVVVVVD VDSTFGGQVV VVVTTDMPYY EELHHHGGWN NACCCSSSSM MLPNNNAAHV LLGGVVVLLD LDPTYAAQII IVRVVEMPNN EELHHHGGWN NACCCSSAAA ALPYYYAAHV LLAATTTVVD VDPQYSSQVV VIRLLPMPYY EELHHHGGWN NTCCCSSSSC C-----FFTK LLAATTTVVD VDPHYSSQVV VIRLLPMPHH EELHHHGGWN NTCCCSSSSC C-----FFTK LLAATTTVVD IDPQYCCQVV VIRLLPMPNN EELHHHGGWN NACCCSSSSC C-----FFTK LLAATTTVVD VDPQYCCQVV VIRLLPMPHH EELHHHGGWN NTCCCSSSSC C-----YYTK LLAATTTVVD VDPQYCCQVV VIRLLPMPNN EELHHHGGWN NTCCCSSSSC C-----FFTK LLAATTTVVD VDPQYCCQVV VI-------- ---------- ---------- ---------- LLAATTTVVD VDPQYCCQVV VIRLLPMPNN EELHHHGGWN NTCCCSSSSC C-----FFTK LLAATTTVVD VDPQYCCQVV VIRLLPMPNN EELHHHGGWN NTCCCSSSSC C-----FFTK LLAATTTVVD VDPQYSSQVV VIRLLPMPYY EELHHHGGWN NTCCCSSSSC C-----FFTK LLAATTTVVD VDPQYCCQVV VIRLLPMPNN EELHHHGGWN NTCCCSSSSC C-----FFTK LLAATTTVVD VDPQYCCQVV VIRLLPMPNN EELHHHGGWN NTCCCSSSSC C-----FFTK LLAATTTVVD LDPTYSSQVV VIRLLPVIHH KKLHHHGGWN NSCCCSSSSC C-----HHSA ---------- ---------- ------MPNN EELHHHGGWN NTCCCSSSSC C-----YYSK LLAATTTVVD VDPSYSSQVV VIRLLPMPNN EELHHHGGWN NTCCCSSSSC C-----YYSK LLAATTTVVD VDPTYSSKVV VIRLLPVPYY EELHHHGGWN NSCCCSSSSC C-----HHSA LLAATTTVVD LDPTYSSKVV VIRLLPVPYY EELHHHGGWN NSCCCSSSSC C-----HHSA ---------- ---------- ------MPFF EELHHHGGWN NSCCCSSSSC C-----HHSA LLAATTTVVD VDPSYSSSVV VIRLLPMPFF EELHHHGGWN NSCCCSSSSC C-----HHSV LLGGTTTVVD VDPTYSSQVV VIRLLPVTHH EELHHHGGWN NACCCSSSSC C-----HHSA IIFFTTTVVD VNPTFCCQVV VIRVVDVPHH EEVHHHGGWN NACCCSSSSC C-----HHTE IIFFTTTVVN VNPTFCCQII IIRVVDVPNN EEVHHHGGWN NACCCSSSSC C-----HHTE ---------- ---------- ---------- ---------- ---------- ---------- LLAATTTVVD VDPTYCCQVV VIRTTYTNSS EELHHHGGWN NTCCCSSSSC CHP---GGVP LLSSTTTVVD VDPTYCCQII IVRTTFTNRR EELHHHGGWN NACCCSSSSC CYDEEESSVP RRKKNNNPPR MVGLGGGSVV VLDGGPVKVV KKELDDQQPT TPRRRIILLK K-------VQ LLVVTTTIID LRPTRGGQVV VISVVSVGGG EEAHHHGGFS SA-------- ---------- LLVVTTTVVD ANPQYGGKVV VVTLLSVGGG EEAHHHDDFT TD-------- ---------- IRRRRFIPGS SSRRIKKPPP EIIVEPPEEE EVSYYSLHVV CCDAAIYIGN NE--EGPGGM LRRRRYIPAS SSRRIKKPPK RVAIEPPEEE VRTYYTYHVV CCDAAIYIGG GP--DGPGGL LRRRRFIPGS SSRRIKKPPP QIHIEPPDDD EKTYYSPHVV CCEGGIYVGG GAGKDGAPGI IRRRRYIPGS SSRRIKKPPP KIHIEPPEEE EKTYYSPHII CCDGGIYVGG GGGKDGPPGI LRRRRYIPGS SSRRIKK--P KIHIEPPEEE EKTYYSPHII CCEGGIYVGG GGGEDGPPGI MRRRRYVPGS SSRRIKKPPP KLAVEPPEEE TRTYYSPHVV CCGGGIYVGN NA--EGPGGM VRRRRYVPDS SSHHIKKPPP QVVVDPPNNN ERTYYAPHVV CCDGGIYIGS SP--EGPGGI VRRRRYIPGS SSRRIKKPPP EIVVEPPEEE ERTYYSPHII CCDGGVYVGS SP--EGPGGV KRRNNKIPGS SSRRIGGSSP ALHVEAASSS EKCVVSTHSS CCSGGEVMLG GD--LQKGSL KRRDDKIPSS SSRRIGGSSP ALHVEPPNNN EKCLLGLHSS CCSGGEVMLG GD--PQKGGL KRRTTKMPCS SSRRIGGSSP ALHVEAAEEE DKCLLGVHSS CCSGGEVMLG GD--SKKGGL KRRTTKVPAS SSRRIGGTTP ALHVEPPKKK DKCLLGFHSS CCSGGEVMLG GD--PEKGGL KRRTTKVPSS SSRRIGGSSP ALHVEPPEEE DKCLLALHSS CCSGGEVMLG GD--VKKGGL ---------- ---------- -----PPKKK DKCLLALHSS CCSGGEVMLG GD--VKKGGL KRRTTKVPSS SSRRIGGSSP ALHVEPPKKK DKCLLALHSS CCSGGEVMLG GD--VKKGGL KRRTTKVPSS SSRRIGGSSP ALHVEPPKKK DKCLLALHSS CCSGGEVMLG GD--VKKGGL KRRNNKVPSS SSRRIGGTTP ALHVEAAKKK DKCLLGPHSS CCTGGEVMLG GD--PKKGGL KRRTTKVPS- ---------- ---------- ---------- ---------- ---------- KRRTTKVPSS SSRRIGGSSP ALHVEPPKKK DKCLLALHSS CCSGGEVMLG GD--VKKDGV ARRRRFIPSS SGRRVAATTP TLHVESSEEE DNILLGPHSS CCSGGDIMLG GD--KEAGNL KRRNNKIPCS SSRRIGGTTP AIHTEPPYYY EKCLLALHSS CCCGGEIMIG GD--PYKGGL KRRNNKIPCS SSRRIGGSSP AIHTEPPYYY EKCLLAPHSS CCCGGEIMLG GD--PCKGGL ARRRRFIPSS SGRRIKKTTP SLHVDPPAAA DKTLLAPHSS CCSGGELMLG GD--KDEGNL ARRRRFIPGS SGRRVKKTTP ALHVEPPEEE DKTLLAPHSS CCSGGEIMIG GD--KDEGNL ARRRRYVPSS SGRRIKKEEP ALYYDPPKKK EKTLLAPHAA CCSGGEILLG GD--EEKGNL VRRRRYVPSS SGRRIKKEEP ALYYDPPKKK EKTLLAPHAA CC-GGEILLG GD--EEKGNL ARRRRFIPSS SGRRVLLKKP ALHVEAAEEE DKTLLGPHSS CCSGGEIMLG GD--KEAGNL ERRSSHIPCS SDRRIEENN- KLETEPPSSS KLNLLSPHSS CCDGGNIMLG GE--ANSGNL ERRSSHIPCS SDRRIEENN- ELQTEPPSSS KLNLLSPHSS CCDGGNIMLG GE--ADSGNL ------VRKS SGVVEGGGG- ---------- ---------- ---------- ---------- PRRDDRVPCS SDRRIGGTTP ALAVEGG--- DGACCTPHTT CCNGGNIMMG GD--AEKG-V PRRDDRVPSS SDFFIVVTTP KIVTDGG--- DSHVVTPHTT CCNGGNIMMG GD--AEKG-I QGGPPQLLSG GKRRLLLYYA DFY------- DFLLLASHAA YYNTTALKVN NE--SLVLNQ -RRRRFWGGT TNRRIHHSSP NLHTDTT--- FSGVVVPHFF AAGSSMMISN ND--DDRTAE -RRRRYWGGT TSKKIHHSSP RLSTTDD--- FSGVVVPHLL AAGRRMLISN NN--KDRTAE DDSSSEEEEP GEEEIIDRRR GDDQ------ -------LAY YYFWWNNNNN NNEVSSEWWA DDTTTEEEEP GEEEVVYRRR GPPQ------ -------FAY YYFWWNNSSS SSGITSEWWT DDTTTDDDDV GEEEIIDRRR GPPQ------ -------KHY YYFWWNNRRR RRDVSSEWWA DDTTTEEEEV GEEEIIDRRR GPPQ------ -------LHY YYFWWNNRRR RRDVTSEWWA DDTTTEEEEI GEEEMMDRRR GEEQ------ -------KHY YYFWWNNRRR RRDVSSEWWG DDSSSEEEEP GEEEVVERRR GPPQ------ -------FAY YYGWWHHYYY YYDVTSEWWG DDNNNEEEEV GEEEIIDRRR GDDQ------ -------LHY YYFWWHHYYY YYDLTSEWWG DDSSSDDDDP GEEEVVERRR GPPQ------ -------LAY YYFWWHHYYY YYDVTSEWWG DDTTTEEEEV GEEEKKPGGG GAAS------ -------MGY YYFWYQQHHH HHNVSTEWWA DDTTTEEEEV GEEEKKPGGG GEEA------ -------MGY YYFWYQQHHH HHNVSTEWWA DDTTTEEEEV GEEEQQPGGG GAAA------ -------MGY YYFWYQQHHH HHNISTEWWA DDTTTEEEEV GEEEQQPGGG GAAA------ -------LGY YYFWYQQHHH HHNISTEWWA DDTTTEEEEV GEEERRPGGG GAAA------ -------SGY YYFWYQQHHH HHNISTEWWA DDTTTEEEEV GEEERRPGGG GAAA------ -------LGY YYFWYQQHHH HHNISTEWWA DDTTTEEEEV GEEERRPGGG GAAA------ -------LGY YYFWYQQHHH HHNISTEWWA DDTTTEEEEV GEEERRPGGG GAAA------ -------LGY YYFWYQQHHH HHNISTEWWA DDTTTEEEEV GEEERRPGGG GSSA------ -------MGY YYFWYQQHHH HHNISTEWWA ---------- ---------- ---------- ---------- ---------- ---------- LLRRREEEEC G--------- ---------- ---------- ---------- -----AISSA LLEEENNNNV GSSSNNRLLL FPPI------ -------KER RRHLYEEWWW WWGWSWIQQC DDTTTEEEEV GEEEAAEGGG EAAA------ -------FGY YYFWYQQHHH HHNISTEWWG DDTTTEEEEV GEEEVVEGGG ESSA------ -------FGY YYFWYQQHHH HHNISTEWWG LLDDDNNNNV GEEEKKPGGG HSSP------ -------FGY YYFWYQQHHH HHNISTSWWG LLEEENNNNV GEEEKKPGGG HSSP------ -------FGY YYFWYQQHHH HHNISTSWWG LLDDDNNNNI NEEEKKPGGG HSSP------ -------FGY YYFWYQQHHH HHKISTSWWG LLDDDNNNNI NEEEKKPDDD ISSP------ -------YGY YYFWYQQHHH HHKISTSWWG LLEEENNNNV GEEEKKPGGG HSSP------ -------FGY YYYWYQQHHH HHKISSSWWG DDTTTEEEEP GPPPAADEEE KTTV------ -------FNY YYFWYQQRRR RRNISTEWWG DDTTTEEEEP GPPPAADGGG KVVV------ -------FNY YYFWYQQRRR RRNISTEWWG ---------- ---------- ---------- ---------- ---------- ----SILRRG FFNNNEEEEL GSSSRRGDDD RKKA------ -------CGY YYYWYQQFFF FFNVASEWWG FFDDDNNNNC GTTTKKGDDD KKKA------ -------CGY YYFWYQQFFF FFDVSSEWWG SSEEEGGGGL AEEEAASQQQ FEEE------ -------LQL LLNHNNNRRR RREESDRPPD NNGGGYYYYV TMMMPPTAAA DDDMGAVGGG AVAADDGYGY YYIRALLKKK KKNLTSSFFT TTGGGYYYYV TIIIPPTDDD GDDLGKTGGG KYAADDGYDY YYVRALLKKK KKNVTSSFFT AA---IDG-- --KKK-RRGN RRIHFDDLKK KRKKRIHSGG GEEERRRMMM AAL--ELLLR TT---FEG-- --SSKGAAGN KKLHVDDLKK KRRRHLYAGG GQQERRRMMM VVL--EVVVR AA---FNG-- --VVLNKKGH RRLHFDDLAA ARRRNVQTGG GAAQQQQMMM AAL--EVVVR AA---FNG-- --VVLNKKGH RRLHFDDLAA ARRRNVQTGG GAANQQQMMM AAL--EVVVR GG---FNG-- --VVLNKKGH KKIHFKKLDD DRKKNVQTGG GAANQQQMMM AAL--EIIIR GG---VDG-- --VVLARRGR RRLHFDDLRR RRRRHLQEGG GDDEQQQLLL VVF--ELLLR GG---VSG-- --LLLGKKGH RRLHVDDLRR RRRRHLQTGG GAAEQQQMMM AAL--ELLLR GG---IGG-- --DDLKGGGR RRLHIDDLRR RRRRHLQAGG GEEEQQQMMM VVL--ELLLR AA---FDGFF FFPPAGLLGS RRIFVDDWRR RHEEIIQTTT T---GGGLLL IIP-LEIIIR AA---FDGFF FFPPAGLLGS HHIHVDDWRR RHEEIIQTKK K---GGGLLL IIP-LEIIIR AA---FDGFF FFPPAGLLGS HHLHVDDWRR RHEEIIQTQQ Q---GGGLLL IIP-LEIIIR AA---LDGFF FFPPAGLLGS HHLYVDDWRR RREEIVQTQQ Q---GGGLLL IIP-LEIIIR AA---LDGFF FFPPAGLLGS HHLYVDDWHH HHEEIVQTKK K---GGGLLL IIP-LEIIIR AA---LDGFF FFPPAGLLGS HHLYVDDWRR RHEEIVQTKK K---GGGLLL IIP-LEIIIR AA---LDGFF FFPPAGLLGS HHLYVDDWRR RHEEIVQTKK K---GGGLLL IIP-LEIIIR AA---LDGFF FFPPAGLLGS HHLYVDDWRR RHEEIVQTKK K---GGGLLL IIP-LEIIIR AA---VNGFF FFPPAGLLGK HHLHVDDWRR RHEEIVQTPP P---GGGHHH IIP-LEIIIR ---------- ---------- ---------- ---------- ---------- ---------- AA---RTGSS SSDDASRRAG IIT------- ---------- ---------- ---------- CC---YTGAA AALLASGGHV IISCLNNYMM MRVVIDESQQ Q---QQQAAA GGAPLCLLLR GG---FLGFF FFMMAGMMGH SSLNVDDWEE EHRRRIQTGG GEE-GGGLLL IIP-LEIIIR GG---FLGFF FFMMAGHHGH SSLNVDDWEE EHRRLVQTGG GKK-GGGLLL IIP-LEIIIR GG---FKGFF FFLLDGLLGR HHLTCQQLRR RGEELRQTGG GNN-GGGLLL LLP-LEIIIR GG---FQGFF FFLLDGLLGR HHLHVSSWGG GGEEIKQTGG GDD-GGGLLL LLP-LEIIIR GG---FKGFF FFLLDGLLGS HHLHVSSWGG GGEEMKQLGG GEE-GGGLLL LLP-LEIIIR GG---FKGFF FFLLDGLLGS HHLHVSSWGG GGEEIKQLGG GPP-GGGLLL LLP-LEIIIR GG---FTGFF FFLLDGLLGR HHLHVDDWGG GGEELKQTGG GSS-GGGLLL LLP-LEVVVR GG---IKGFF FFPPEGLLGN SSVHIEEWSS SKKKYLQTPP PQQPGGGAAA LLP-LEVVVR GG---IKGFF FFPPEGLLGN SSVHIEEWTT TKKKHLQTPP PMMPGGGAAA LLP-LEVVVR GG---VRDEE EELLEPLLIK CCKRV----- ---------- ---------- ---------- GG---FRGYY YYPPDTQQGC RRLNFRRWEE EREELFQTGG GDD-GGGLLL TTP-LEIIIR GG---WRGWW WWNNDSQQGC RRLNFKKWTT TQTTLYQTGG GSS-GGGIII TTP-LEIIIR DD---AESSS SSSSTPLLPQ HHVAELL--- ---------- ---------- ---------- TTNNYMFGQQ QQLLAKRRGN TTIVQDDLTT TRQQPKKVPP PGGA------ ----LEIIIR TTNNYMFGKK KKLLAKHHGN TTVVTDDLTT TKQQPKKVPP PGGA------ ----LEIIIR RPHHHPTMGF FNNVSKKLLL LSSSSSIFDW NNAEEKKKVV IEPPLGPEII ILLKKPPVVT RPHHHPTMGF FNNLNKKLLL LSSSSSIFDW QQAEERRRVV IDPPFGPPVV VLLKKPPVVT RPHHHPVYGF FGGVDTTLLL LEEESSIWGF HHVKKKKKTT ATPPAAPPLL LLLQQPPVVT RPHHHPVYGF FGGVDTTLLL LEEESSIWGF HHAEEKKKTT ATPPAKPPLL LLLQQPPVVT RPHHHPSYGF FGGVDTTLLL LQQQAAIWDF EEAKKKKKTT ITPPAAPDLL LLLKKPPVVT RPHHHPTYGF FNNISKKLLL LSSSSSIYKW AAVRRKKKVV IEAAAPPPVV VLLKKPPVVT RPHHHPTYGF FNNVSKKLLL LSSSSSIYNW HHLKKKKKVV IDPPAEPPII ILLKKPPVVT RPHHHPAYGF FGGVSEELLL LSSSSSVHNW GGIRRKKKVV IEPPAPPPLL LLLKKPPVVT RFHHHPSQGF FGGLSNNQQQ QRRRYYKG-- ---------- TWVVIVKVKK KGGWWGGIIT RFHHHPDQGF FGGLSNNQQQ QRRRYYKG-- ---------- TWVVIVKVKK KGGWWGGIIT RFHHHPDQGF FGGLSTTQQQ QRRRYYKG-- ---------- TWVVIVKVKK KGGWWGGIIT RFHHHPDQGF FGGLSTTQQQ QRRRFFKG-- ---------- TWVVIVKVKK KGGWWGGIIT RFHHHPDQGF FGGLSTTQQQ QRRRYYKG-- ---------- TWVVIVKVKK KGGWWGGIIT RFHHHPDQGF FGGLSTTQQQ QRRRYYKG-- ---------- TWVVIVKVKK KGGWWGGIIT RFHHHPDQGF FGGLSTTQQQ QRRRYYKG-- ---------- TWVVIVKVKK KGGWWGGIIT RFHHHPDQGF FGGLSTTQQQ QRRRYYKG-- ---------- TWVVIVKVKK KGGWWGGIIT RFHHHPAQGF FGGLSTTQQQ QRRRYYKG-- ---------- TWVVIVKVKK KGGWWGGIIT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RSHHHKNQDY YVVVSSSRRR RGGGSSDY-- ---------- AVKKLLVVAA AKKFFNNFFP RFHHHPDQGL LGGLSTTFFF FRRRYYKG-- ---------- KWVVIVKVEE EGGWWGGIIT RFHHHPDQGL LGGLSSSFFF FRRRYYKG-- ---------- KWVVIVKVEE EGGWWGGIIT RFHHHPATGF FGGLSNNIII IRRRFFKG-- ---------- SWAAIVKVQQ QNNWWGGIIT RFHHHPATGF FGGLTNNIII IRRRFFKG-- ---------- SWVVIVKVQQ QNNWWGGIIT RFHHHPSTGY YGGLSNNIII IRRRFFKD-- ---------- TWVVIVKVEE ENNWWGGIIT RFHHHPSTGF FGGLSNNIII IRRRFFKE-- ---------- TWVVIVKVEE ENNWWGGIIT RFHHHPSTGY YGGLTNNVVV VRRRFFKG-- ---------- SWAAIIKVRR RNNWWGGIIT RFHHHPTHAF FGGLGGGFFF FRRRHHPN-- -----TTT-- THVVAIKVSS SGGWWAAIIT RFHHHPTHAF FGGLGAAFFF FRRRHHPN-- -----KKK-- VQVVAIKVEE ENNWWAAIIT ---------- ---------- ---------- ---------- ---------- ---------- RFHHHPRQGY YGGFXXXXXX XXXXXX---- ---------- ------QGEE ENNGGGGMMT RFHHHPKEGF FGGLNKKFFF FHHHKKKS-- -----EEEFF EADDIGDTGG GSSGGGGIIS ---------- ---------- ---------- ---------- ---------- ---------- RFWWWSNYAF FTTLTQQWWW WLLLYYEG-- ---------- -----WAVAA ADDIIPPPPV RCWWWEAYCF FSSLTQQWWW WLLLYYEG-- ---------- -----WAVAA ADDIIPPPPV TTDIIDDDII SSSLLLDDKF FLLYLSSLLW GEEEYDSNPP PPPFKPVGGF FRRDDDHHHH TTDIIDDDII SSSLLLDDRF FLLYVSSLLW GEEEYDTNPP PPPHQPRGGY YRRPPPHHHH TTDIIDDDLL SSSLLLDDRF FLLYVSSCCW GEEEYDSDPP PPPHNPVGGA ARRPPPHHHH TTDIIDDDLL SSSMMMDDRF FLLYVSSCCW GEEEYDSDPP PPPRKPKGGA ARRPPPHHHH TTDIIDDDLL SSSLLLDDKY YLLYVAACCW GEEEYDSDPP PPPMNPVGGV VKKPPPHHHH TTDIIDDDLL SSSMMMDDRF FLLYVSSCCW GDDDYDSDPP PPPFEPKGGV VRRTTTHHHH TTDIINNNLL SSSVVVDDRF FLLYVSSCCW GEEEYDSDPP PPPFNPRGGV VRRGGGHHHH TTDIINNNLL SSSLLLDDRF FLLYVSSCCW GEEEYDSDPP PPPFNPRGGV VKKAAAHHHH TTDIILLLLL SSSLLLDDRF FLLYFSSNNW LDDDYDSNPP PPPQKPRGGI IRRGGGSSSS TTDIILLLLL SSSLLLDDRF FLLYFSSNNW LDDDYDSNPP PPPKKPRGGI IKKGGGSSSS TTDIILLLLL SSSLLLDDRF FLLYFSSNNW LDDDYDSDPP PPPQRPRGGI IKKGGGPPPP TTDIILLLLL SSSLLLDDHF FLLYFSSNNW LDDDYDSDPP PPPQRPRGGI IKKGGGPPPP TTDIILLLLL SSSLLLDDRF FLLYFSSNNW LDDDYDSDPP PPPQRPRGGI IKKGGGPPPP TTDIILLLLL SSSLLLDDRF FLLYFSSNNW LDDDYDSDPP PPPQRPR--- ---------- TT-------- ---------- ---------- ---------- ---------- ---------- TTDIILLLLL SSSLLLDDRF FLLYFSSNNW LDDDYDSDPP PPPQRPRGGI IKKGGGPPPP TTDIILLLLL SSSLLLDDRF FLLYFNNNNW LDDDYDSDPP PPPKRPRGGI IKKGGGPPPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPPAAWWWII FFFFFFSDLL LIIIFLLSS- ---------- ---------- ---------- TTDIILLLII SSSLLLDDRF FLLYFSSNNW LDDDYDTDPP PPPRNPKGGI IRRGGGPPPP TTDIILLLII SSSLLLDDRF FLLYFSSNNW LDDDYDTDTT TTTRNPKGGI IRRGGGPPPP TTDFFLLLII SSSLLLDDRF FLLYFVVNNW LDDDYNEDLL LLLKNPVGGI IKKSSSPPPP TTDFFLLLII SSSLLLDDRF FLLYFVVNNW LDDDYNEDVV VVVKNPKGGI IKKSSSPPPP TTDFFLLLII SSSLLLDDRF FLLYFVVNNW LDDDYNEDPP PPPKNPVGGL LKKSSSPPPP TTDFFLLLII SSSLLLDDRF FIIYFVVNNW LDDDYNEDPP PPPKNPVGGL LKKSSSPPPP TTDFFVVVII SSSLLLDDRY YLLYLVVNNW LDDDYNEDPP PPPAKPVGGL LKKSSSEEEE TTDIILLLII SSSMMMDDRF FLLYVSSCCW LDDDYDSDPP PPPLKVKSSV VTTSSSNNNN TTDIILLLII SSSMMMDDRF FLLYVSSCCW LDDDYDSDPP PPPKNPKSSI ISSTTTTTTT ---------- ---------- ---------- ---------- ---------- ---------- TTDIILLLII SSSLLLDDRY YLLYFSSNNW RDDDYDSDRR RRRANPRGGI IRRAAAPPPP SSDIIIIIII SSSLLLDDRF FLLYVNNCCW RDDDYDTDPP PPPENPKGGI ISSLLLPPPP ---------- ---------- ---------- ---------- ---------- ---------- VVDIISSSII AAAAAADDQT TLLWINNSSF MKKKFDSDPP PPPHKPFYYV V--------- VVDIISSSII SSSNNNDDSR RLLWVNNTTF MKKKFDSDPP PPPHHPRYYV V--------- P--------- ---------- ---AGGHLLL LGPPPEESRR DGSLLLYYSD DNQQQYPEGG P--------- ---------- ---SGGAAAA AGPPPSSSRR DGSLLLYYSN NNQQQYP-GG P--------- ---------- ---NGGRFFF FGPPPEESRR DGSLLLYYSD DDQQQYPDGA P--------- ---------- ---NGGKFFF FAPPPEESRR DGSLLLYYSD DDQQQYPDGG P--------- ---------- ---NGGKFFF FYPPPEESRR DGSLLLYYSD DEQQQYPGDA PG-------- ---------- AAAKNNGLLL LGPPPEESRR DGSLLLYYGD DPQQQYPEGG P--------- ---------- AAATSSALLL LGPPPEESRR DGSLLLYYRD DEQQQYPDGG P--------- ---------- ---ASSGLLL LGPPPEESRR DGSLLLYYAD DEQQQYPVGG VQVLLL-DQQ QQECCQELLV VVVKGGKIII IGPPPQQSLL DGSLLLYYSD DKQQQY-PDR VQVLLL-DQQ QQECCQELLV VVVKGGKVVV VGPPPQQSLL DGSLLLYYSD DKQQQY-PNR VQVLLL-DQQ QQESSQELLV VVVKGGKVVV VGPPPQQSLL DGSLLLYYSD DKQQQY-PDR VQVLLL-DQQ QQESSQELLV VVVKGGKVVV VGPPPQQSLL DGSLLLYYSD DKQQQY-PDR VQVLLL-DQQ QQESSQELLV VVVKGGKVVV VGPPPQQSLL DGSLLLYYSD DKQQQY-PDR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VQVLLL-DEE EEESSQELLV VVVKGGKVVV VGPPPQQSLL DGSLLLYYSD DKQQQY-PDR VQVLLL-DQQ QQESSQELLV VVVKGGKVVV VGPPPQQSLL DGSLLLYYSD DKQQQY-PDR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VTVLLL-DKK KKDCCQDVVI VVVKGGKVVV VGPPPQQSLL DGSLLLYYSD DKQQQY-PDK VTVLLL-DKK KKECCQDVVT VVVKGGKIII IGPPPQQSLL DGSLLLYYSD DKQQQY-PDK VAAIII-EDD DDGWWQDPPE IIIQGGQLLL LGPPPQQTLL DGSLLLFFSD DKQQQY-PGE VVAVVV-DDD DDGWWQDPPE IIIQGGKLLL LGPPPQQSLL DGSLLLFFSD DKQQQY-PKE VKAVVV-EDD DDGFFQDPPQ IIIKGGKLLL LGPPPQQSLL DGSLLLFFSD DRQQQY-PED VKAVVV-EDD DDGFFQEPPQ IIIKGGKLLL LGPPPQQSLL DGSLLLFFSV VVSSSY-PEE VVYVVV-EDD DDDEEQSPPQ VVVKGGHLLL LGPPPQQSLL DGSLLLFFSD DEQQQYGQDK VKVLLL-GEE EEK--PELLY VVVKGGRIII IGPPPQQSLL DGSLLLYYKD DDQQQY-PEK VKVLLL-EDD DDH--EPLLY VVVKGGRIII IGPPPQQSLL DGSLLLYYKD DDQQQY-PER ---------- ---------- ---------- -GPPPQQSVV DGSFFFYYSD DKQQQY-PNK RRVLLL-DPP PPEEEAEVVF LLLKGGRLLL LGPPPQQSLL DGSLLLFFSD DKQQQY-PEA NVIVVVEDKK KKEEERPRRY VVVKGGRLLL LGPPPQQSLL DGSLLLYYSD DKQQQY-PKS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----SSSWW DGSLLLLLAD D--------K ---------- ---------- ---------- -----SSSWW DGSLLLLLAD D--------K GMVVKKKLN- ---PGLEEII KEEEFFFFDD G----ARSQQ QRLSDDAAAA AAASSSYYYC GMAAKKKVN- ---PGLEELL KEEEFFFFDD G----ARAQQ QRLWDDAAAA AAASSSFFFC AQVVLLLAG- ---PGLTTLL DDDDYYWWEE PGG--YRAQQ QRLEDDCCCC CCCSSSFFFC GEVVMMMAG- ---GGLEELL KDDDYYFFSS PGG--YRAQQ QRLEDDCCCC CCCSSSFFFC AMVVMMMAG- ---EGLTTLL KDDDFFWWDD PGG--YRSQQ QRLEDDCCCC CCCSSSFFFC GMVVKKKLG- ---PGIEEFF PKKKFFFFEE PGG--HRPQQ QRLQDDCCCC CCCSSSYYYC GMVVKKKVN- ---PGMQQFF PNNNFFFFDD G----QRVQQ QRLQDDAAAA AAASSSYYYC GIAAKKKAD- ---PGLSSLL PGGGFFFFEE GGG--LRPQQ QRLEDDSSSS SSSSSSYYYC RGSSVVVMVD VVTVGLKKLL PNNNFFLLDD GEEPPALAEE ERYPDDCCCC CCCSIIWWWI RGSSVVVMID VVTAGLKKLL PNNNFFLLDD GEEPPALAEE ERYPDDCCCC CCCSIIWWWI RGSSVVVMID VVTVGLKKLL PNNNFFLLDD GEEPPALAEE ERYPDDCCCC CCCSIIWWWL RGSSVVVMID VVTVGLTTLL PNNNFFLLDD GEEPPALAEE ERYPDDCCCC CCCSIIWWWL RGSSVVVMVD VVTVGLKKLL PNNNFFLLDD GEEPPALAEE ERYPDDCCCC CCCSIIWWWI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RGSSVVVMVD VVTVGLKKLL PNNNFFLLDD GEEPPALAEE ERYPDDCCCC CCCSIIWWWI RGSSVVVMID VVTVGLKKLL PNNNFFLLDD GEEPPALAEE ERYPDDCCCC CCCTIIWWWL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- KGSSVVVMID VVTEGLKKLL PNNNFFLLDD GEEPPVLAEE ERYPDDCCCC CCCSIIWWWV KGAAVVVMID VVTKGLKKLL PNNNFFLLDD GEEPPVLAEE ERYPDDCCCC CCCTIIWWWI EGSSHHHIID VVTEGLKKII PNNNFFFFDD GEEPPALAEE ERYPDDCCCC CCCTIIWWWI EGSSHHHIID VVTEGLKKII PNNNFFFFDD GEEPPSLAEE ERYPDDCCCC CCCTIIWWWI DGSSHHHIID VVTEGLSSII PNNNFFFFDD GEEPPALAEE ERYPDDCCCC CCCTIIWWWI EGSSHHHIID GGTEGLTTII PDDDFFFFDD GEEPPSLAEE ERYPDDCCCC CCCTIIWWWI KGSSHHHMID VVTEGLSSII PNNNFFFFDD GEEPPSLAEE ERYPDDCCCC CCCTIIWWWI KGAATTTMVN IIPEGMEEII RDDDFFLLDD GIIPPYLAEE ERYPDDCCCC CCCTIIWWWI RGAATTTMID VVPIGMVVII KNNNFFLLDD GVVPPYLAEE ERYPDDCCCC CCCTIIWWWI KGSSVVVMID VVTEGLTTVV KNNNFFLLDD GEEPPCLADD DRFPDDSSSS SSSTIILLLA AGGGTTTILD IIVEGMKKLL ENNNFFLLDD GEEPPGLPEE ER-------- ---------- SGGGHHHIID VVTVGISSLL EDDDFFLLDD AEEPPSLPEE ERYPDDCCCC CCCTIIWWWL ---------- ---------- ---------- ---------- ---------- ---------- KGKKDDDDYL KKYNDKEELL EDDDFFAADD YLL---RAII IRFGAALLLL LLLY------ KGKKDDDDFL KKYYDKEELL EQQQFFAADD YEE---RPQQ QRFGAALLLL LLLYPPAAAG C------ C------ CVKR--- CV----- CV----- C------ C------ C------ I------ I------ L------ L------ I------ ------- ------- I------ L------ ------- ------- ------- V------ I------ I------ I------ I------ I------ I------ I------ I------ A------ ------- LA----- ------- ------- GRLVQQQ 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMNSKKQPAA PCTAPTTGGL LTTAAGMMQQ SSSPTALLLL LLSSLLTTPP PSPPVRRAAA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QQEAAATFFF SSSAVLLSSS PSSESSKKGG GTRRPGGIIS SSSAAKQVVP PSQQVVWWWH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M ---------- ---------- ---------- ---------- ---------- ------LLLK ---------- ---------- ---------- ---------- ---------- ---------- AAGRSSPTTT LLPPNRRPPT PPPNPPLLAA ASPPPRRTTR RLLPPYRIIN NVPPLLCCCP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AIPRRRDPPP PTFFYPPKAP PDLLAYVVAA ---------- ---------- ---------- -MKPPPDPPP PTFFYPPRAP PDIIAYVVAA ---------- ---------- ---------- --SPPPDPPP PTFFHAPEAP PEFFAYTTLL ---------- ---------- ---------- --TPPPDPPP PTFFHAPKAP PNFFAYTTLL ---------- ---------- ---------- --TPPPDPPP PTFFYPAKGP PKLLAFTTLL ---------- ---------- ---------- -MTPPPDPPP PSFFYPPRAP PTIIAYVVAA ---------- ---------- ---------- -MTPPPDPPP PTFFYPPRAP PKLLAYVVVV ---------- ---------- ---------- -MSPPPDPPP PTFFYPPKAP PRLLGYVVAA ---------- ---------- ---------A KCKCCCGPPP PGYYPTLEGP PEIIVYLLPP ---------- ---------- ---------- ---------- --------GP PEIIVYLLPP LLLPPPGGGA AAALLLPPRG GGLLG--AAS QCKCCCGPPP PGYYPSLEGP PEIIVYLLPP ---------- ---------- ---------- ---------- --------GP PEIIIYLLPP ---------- ---------- ---------A KCNCCCGPPP PGYYSTLEGP PEIIVYLLPP ---AAERRRA AAFLLLVVQP PPMMIAASSA KCNCCCGPPP PGYYSTLEGP PEIIVYLLPP ---------- ---------- ---------A KCNCCCGPPP PGYYSTLEG- ---------- ---------- ---------- ---------A KCNCCCGPPP PGYYSTLEGP PEIIVYLLPP LLLGGKEEEH HHTQQQFFSG GGQQQEEDDA KCDCCCGPPP PGYYPTQEGP PEIIVYLLPP SSSQQGCCCD DDQNNNLLTY YYCCVFFTTP KCNCCCGPPP PGYYSTLEGP PEIIVYLLPP ---------- ---------- ---------A KCNCCCGPPP PGYYSTLEGP PEIIVYLLPP AAARRHSSSQ QQHMMMAAAV VVEEAAAAAG TCHKKKGPPP PGYYATLEGP PKLLVYVVTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M KCSCCCGPPP PGYYKSLDGP PEIIVYLLPP ---------- ---MMMVVDH HHGGNEEKKS VNCSSSGPPP PGYYASIEGP PSLLIYVVTT ---------- ---MMMVVQH HHAASEEKKN QQCSSSGPPP PGYYASLEGP PTLLIYVVTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -RLGGGGPPP PGYYATLAGP PKLLIYVVTT ---------- ---------- ----AAAAAG ACGTTTGPPP PGYYATLEGP PKLLLYVVTT ---------- ---------- ----SPPNNG KCG---GPPP PGYYASADGP PEVVLFVVTT ---------- ---------- ----P----P KCG---GPPP PGYYASADGP PEVVLFVVTT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SEKCCCGPPP PGYYATLDGP PKLLLYVVVV ---------- ---------- ---------- ---------- --------GP PKLLLYTTVV ---------- ---------- ---------- ------MPPP PGLLIT-DLD DFLLYFSSNN MMMKKRRRR- ---------A AALLG--AAA GLFFFFADDD DETTCQPYTG GEFFVYVVWW MMMKKRFFFG GGPMMMAARA AALLGLLAAA AAARRRADDD DETTCAPYTG GDYYVYVVWW AYGGTGRRFF FVVVVPPKTT TYSKHVLPPY IIIINNNDLH FFFGWWNACC CSSAC---PP AYGGTGAAFF FVVVVPPKTT TYGKYLLPPY IIIIGGGDLH FFFGWWNACC CSSAC---PP LSDDFSRRAA AIIIVPPGTT TYGKHVMPPN TTTTGGGDFH FFFGWWNACC CSSSS---PP LSDDFSKKAA AIIIVPPGTT TYGQHVMPPN KKKKGGGDFH FFFGWWNACC CSSAS---PP LSDDASKKGG GVVVVPPTKK KFGQHLMPPN KKKKGGGDFH FFFGWWNACC CSSAS---PP ADEERKQQAA AVVVVPPARR RYASGVMPPH AAAAGGGDLH FFFGWWNACC CSSCC---PP VNMMANKKAA AVVVVSSQTT TFGQGTMPPY TTTTGGGGLH FFFGWWNACC CSSMC---PP ADGGRERRAA ALLLLPPDTT TYAQGVMPPN AAAAAAADLH FFFGWWNACC CSAAC---PP PYNNTGAAYY YVVVVPPKQQ QYSQHLMPPY LLLLKKKDLH SSSGWWNTCC CSSC------ PYNNTGAAYY YVVVVPPKHH HYSQHLMPPH LLLLKKKDLH SSSGWWNTCC CSSC------ PYNNTGAAYY YVVVIPPKQQ QYCQHLMPPN LLLLRRRDLH SSSGWWNACC CSSC------ PYNNTGAAYY YVVVVPPKQQ QYCQHLMPPH LLLLKKKDLH SSSGWWNTCC CSSC------ PYNNTGAAYY YVVVVPPKQQ QYCQHLMPPN LLLLKKKDLH SSSGWWNTCC CSSC------ PYNNTGAAYY YVVVVPPKQQ QYCQE----- ---------- ---------- ---------- ------AAYY YVVVVPPKQQ QYCQHLMPPN LLLLKKKDLH SSSGWWNTCC CSSC------ PYNNTGAAYY YVVVVPPKQQ QYCQHLMPPN LLLLKKKDLH SSSGWWNTCC CSSC------ PYNNTGAAYY YVVVVPPKQQ QYSQHLMPPY LLLLKKKDLH SSSGWWNTCC CSSC------ PYNNTGAAYY YVVVVPPKQQ QYCQHLMPPN LLLLKKKDLH SSSGWWNTCC CSSC------ PYNNTGAAYY YVVVVPPKQQ QYCQHLMPPN LLLLKKKDLH SSSGWWNTCC CSSC------ TYGGTGKKYY YVVVLPPSTT TYSQHLVIIH IIIIGGGDLH SSSGWWNSCC CSSC------ ---------- ---------- ------MPPN TTTTNNNDLH SSSGWWNTCC CSSC------ PYSSTGKKYY YVVVVPPKSS SYSQHLMPPN VVVVNNNDLH SSSGWWNTCC CSSC------ TYGGTGKKYY YVVVVPPSTT TYSKHLVPPY VVVVGGGDLH TTTGWWNSCC CSSC------ TYGGTGKKYY YVVVLPPNTT TYSKHLVPPY VVVVGGGDLH TTTGWWNSCC CSSC------ ---------- ---------- ------MPPF VVVVGGGDLH SSSGWWNSCC CSSC------ TYGGTGKKYY YVVVVPPSSS SYSSHLMPPF VVVVGGGDLH SSSGWWNSCC CSSC------ TYGGTGKKYY YVVVVPPNTT TYSQHLVTTH VVVVGGGDLH SSSGWWNACC CSSC------ T---NAGGAA AVVVVPPETT TFCQSVVPPH IIIIGGGDVH TTTGWWNACC CSSC------ T---HAGGAA AVVVVPPETT TFCQSVVPPN IIIIGGGDVH TTTGWWNACC CSSC------ ---------- ---------- ---------- ---------- ---------- ---------- VQNNLDHHYY YVVVVPPATT TYCQHTTNNS KKKKHHHNLH SSSGWWNTCC CSSCFVVVPP VQNNLDHHYY YVVVVPPETT TYCQHTTNNR KKKKGGGDLH SSSGWWNACC CSSCYVVVDD NHDDIRDDDD DPPPMGGQLL LGGSKGVKKV LLLLEEEDED SSSQPPTPRR RILK------ WGEEGMEEKK KIIILPPGTT TRGQNVVGGG ----RRRNAH GGGGFFSA-- ---------- WGEEGVEEKK KVVVAPPKQQ QYGKNLVGGG ----RRRNAH SSSDFFTD-- ---------- PNGG-PNIIE RRRIPGGLRS SSSSRITKKK PNNPPPPRRE PPPIVVIEEV KKKKSGGGSS PNAA-PFLLE RRRIPAALRS SSSSRVTKKK PDDKKKKRRR PPPVIIVEEA VVGGTGGGTT PLTTGAFLLE RRRIPGGLRS SSSSRITKKK PHHPPPPTTQ AAAIIIIEEI LLAATGGGSS PLAAGAFIIE RRRIPGGLRS SSSSRITKKK PDDPPPPTTK AAAIIIIEEV FFKKTGGGSS PLTTGAFLLE RRRIPGGIRS SSSSRVVKKK -EEPPPPLLK AAAIIIIEEV FFAATGGGSS PNAAPPHMME RRRVPGGLRS SSSSRLTKKK PDDPPPPLLK PPPLVVIEEL AAEETGGGSS PNAAPPHVVE RRRVPDDIRS SSSSHLTKKK PDDPPPPTTQ PPPVVVIDDL AAEETGGGAA PYAAPPHVVE RRRIPGGIRS SSSSRVTKKK PDDPPPPRRE PPPIVVIEEL HHRRTGGGSS --FFGSTKKS RRNIPGGLMS SSSSRVVGGG SEEPPPPRRA PPPLVVIEEI QQAACNNNSS --FFGSTKKS RRDIPSSIIS SSSSRVVGGG SEEPPPPRRA PPPLVVIEEI HHAACNNNGG --FFGSTKKS RRTMPCCLMS SSSSRVVGGG SDDPPPPRRA PPPLVVIEEI HHAACGGGGG --YYGITKKA RRTVPAALIS SSSSRVVGGG TEEPPPPRRA PPPLVVIEEI HHTTCNNNGG --FFGSTKKS RRTVPSSLIS SSSSRVVGGG SEEPPPPRRA PPPLVVIEEI HHAACEEEAA ---------- ---------- ---------- ---------- ---------I HHAACEEEAA --FFGSTKKS RRTVPSSLIS SSSSRVVGGG SEEPPPPRRA PPPLVVIEEI HHAACEEEAA --FFGSTKKS RRTVPSSLIS SSSSRVVGGG SEEPPPPRRA PPPLVVIEEI HHAACEEEAA --FFGSTKKS RRNVPSSFIS SSSSRVVGGG TEEPPPPRRA PPPLVVIEEI HHEECGGGGG --FFGSTKKS RRTVPSSL-- ---------- ---------- ---------- ---------- --FFGSTKKS RRTVPSSLIS SSSSRVVGGG SEEPPPPRRA PPPLVVIEEI HHAACEEEAA --HHGPSAAK RRRIPSSLLS SSGGRVTAAA TDDPPPPRRT PPPLVVVEEI AAEEIGGGGG --YYGASKKV RRNIPCCLIS SSSSRVVGGG TDDPPPPRRA PPPITTVEEV FFWWCGGGAA --YYGSSKKV RRNIPCCLIS SSSSRVVGGG SDDPPPPRRA PPPITTVEEV FFWWCGGGAA --HHGPSAAE RRRIPSSLVS SSGGRITKKK TNNPPPPRRS PPPLVVVDDI IIQQTGGGAA --HHGPSAAQ RRRIPGGIVS SSGGRITKKK TNNPPPPRRA PPPLVVVEEI SSTTTGGGAA --HHGASAAD RRRVPSSLIS SSGGRITKKK ENNPPPPRRA PPPLYYVDDI AAEETGGGAA --HHGASVVD RRRVPSSLIS SSGGRITKKK ENNPPPPRRA PPPLYYVDDI AADDTGGGAA --HHGPSAAS RRRIPSSLLS SSGGRVTLLL KDDPPPPRRA PPPLVVVEEI AAEETGGGGG --HHDPTEEK RRSIPCCLNS SSDDRIVEEE NEE----RRK IIILTTIEEL HHSSN---SS --HHDPTEEK RRSIPCCLNS SSDDRIVEEE NEE----RRE IIILTTIEEL HHAAN---SS ---------- ---VRKKLSS SSGGVVVGGG G--------- ---------- ---------- P-GGGEVPPT RRDVPCCLNS SSDDRITGGG TDDPPPPRRA PPPLVVIEEV LLKKADDDTT DESSSTVPPK RRDVPSSLNS SSDDFLVVVV TDDPPPPRRK PPPITTIDDV LLKKHNNNTT ----GRVQQG GGPLLSSLDG GGKKRTSLLL YSSAAAAWWD KKKF-----L IIKKLVVVAA ---------D RRRWGGGLDT TTNNRFVHHH SDDPPPPSSN PPPLTTIDDV KKDDGGGGVV ---------D RRRWGGGLDT TTSSKFVHHH SDDPPPPAAR PPPLTTITTV EEKKGGGGVV RLHHVHCGGD DYLEEEGEGP GIMLDYSSFP LGWEEIDRGD Y--------- -----LADWW KYHHVHCGGD DYLPPDGEGP GILLDDTTFP IGWEEVYRGP Y--------- -----FADWW RPHHVHCGGE EYLAADGDGA PIIMDETTFV LGWEEIDRGP D--------- -----KHDWW RPHHIHCGGD DYLGGDGNGP PVIMDETTFV LGWEEIDRGP T--------- -----LHDWW RPHHIHCGGE EYLGGDGDGP PIILDETTFI LGYEEMDRGE T--------- -----KHDWW RPHHVHCGGG GYLAAEGKGP GIMLDQSSFP LGWEEVERGP Y--------- -----FADWW RPHHVHCGGD DYLPPEGEGP GIILDDNNLV LGWEEIDRGD Y--------- -----LHDWW RPHHIHCGGD DYLPPEGDGP GVVMDESSFP LGWEEVERGP Q--------- -----LADWW NTHHSHCLLS SVTDDLQNGK GFLLDETTFV KGWEEKPGGA P--------- -----MGDWW NLHHSHCLLS SVSDDPQNGK GFLLDETTFV KGWEEKPGGE P--------- -----MGDWW YVHHSHCLLS SVTDDSKNGK GFLLDETTFV KGWEEQPGGA P--------- -----MGDWW FFHHSHCLLS SVTDDPENGK GFLLDKTTFV KGWEEQPGGA P--------- -----LGDWW FLHHSHCLLS SVSDDVKNGK GFLLDETTFV KGWEERPGGA P--------- -----SGDWW FLHHSHCLLS SVSDDVKNGK GFLLDETTFV KGWEERPGGA P--------- -----LGDWW FLHHSHCLLS SVSDDVKNGK GFLLDETTFV KGWEERPGGA P--------- -----LGDWW FLHHSHCLLS SVSDDVKNGK GFLLDETTFV KGWEERPGGA P--------- -----LGDWW TPHHSHCLLT TVTDDPKNGK GFLLDETTFV KGWEERPGGS P--------- -----MGDWW ---------- ---------- ---------- ---------- ---------- ---------- FLHHSHCLLS SVSDDVKNGK DSVLL-RRLC SG-------- ---------- ---------- FPHHSHCLLS SICDDKENAA GGLLLSEEFV KGGSSNRLFP S--------- -----KETLL NLHHSHCLLC CISDDPYNGK GFLLDETTFV KGWEEAEGEA P--------- -----FGDWW NPHHSHCLLC CISDDPCNGK GFLLDETTFV KGWEEVEGES Q--------- -----FGDWW YPHHSHCLLS SLCDDKDNAE GGLLLSDDFV KGWEEKPGHS L--------- -----FGDWW YPHHSHCLLS SICDDKDNAE GGLLLSEEFV KGWEEKPGHS L--------- -----FGDWW YPHHAHCLLS SICDDEENAK GGLLLSDDFI KNWEEKPGHS L--------- -----FGDWW FPHHAHCRR- -ICDDEENAK GGLLLSDDFI KNWEEKPDIS L--------- -----YGHWW FPHHSHCLLS SICDDKENAA GGLLLSEEFV KGWEEKPGHS L--------- -----FGDWW FPHHSHCLLD DITEEANTPS GFLLDKTTFP KGWPPADEKT P--------- -----FNDWW FPHHSHCLLD DITEEADSPS GFLLDKTTFP KGWPPADGKV P--------- -----FNDWW ---------- ---------- ---------- ---------- ---------- ---------- APHHTHCLLN NIIDDAENAK GDVEFKNNFL VGWSSRGDRK L--------- -----CGDWW APHHTHCLLN NIVDDAEYAK GDILFSDDFC IGWTTKGDKK L--------- -----CGDWW ISHHADYQQN NLGEESLVPV LGQTSHEENL SAGEEASQFE I--------- -----LQSHH GPHHFFALLG GMLDDDDGGR TLEYNDGGEV ATWMMPTADD QGGGVVGDAA AADDDYGDRR GPHHLYALLG GLLNNKDGGR TLEYTAGGEV ATWIIPTDGD RGGGTTG-KA AADDDYDDRR WWNLL--PEE EVLLVVSSSS PPNN-TDDG- KHHHLLLLKR RRIHWDDDLL RRKIIHHLTT WWNLL--PGG GVMMIITTTS PPRR-CEEG- SCCCLLLLKA KKLHWDDDLL RRRLLYYIDD WWNLL--PDD DYMMVVSSSS PPPP-QNNG- VDDDLLLLLK RRLHWDDDLL RRRVVQQIDD WWNLL--PDD DYMMVVTTTS PPPP-QNNG- VDDDLLLLLK RRLHWDDDLL RRRVVQQIDD WWNLL--PDD DYMMVVSSSS PPPP-QNNG- VDDDLLLLLK KKIHWKKKLL RRKVVQQIDD WWHLL--GDD DTLLVVTTTS PPDD-MDDG- VIIILLLLLR RRLHWDDDLL RRRLLQQIDD WWHLL--GDD DTLLLLTTTS PPRR-MSSG- LEEELLLLLK RRLHWDDDLL RRRLLQQLDD WWHLL--GDD DTMMVVTTTS PPNN-MGGG- DIIILLLLLG RRLHWDDDLL RRRLLQQLDD WWQPP--RNN NVMMVVSSST PPNN-VDDGF PVVVEEEEAL RRIFWDDDWW HHEIIQQLQQ WWQPP--RNN NIMMVVSSST PPNN-VDDGF PVVVEEEEAL HHIHWDDDWW HHEIIQQLQQ WWQPP--RNN NVMMIISSST PPNN-VDDGF PVVVEEEEAL HHLHWDDDWW HHEIIQQLTT WWQPP--RNN NVMMIISSST PPNN-VDDGF PVVVKKKKAL HHLYWDDDWW RREVVQQLPP WWQPP--RNN NVMMIISSST PPNN-VDDGF PVVVEEEEAL HHLYWDDDWW HHEVVQQLSS WWQPP--RNN NVMMIISSST PPNN-VDDGF PVVVEEEEAL HHLYWDDDWW HHEVVQQLSS WWQPP--RNN NVMMIISSST PPNN-VDDGF PVVVEEEEAL HHLYWDDDWW HHEVVQQLSS WWQPP--RNN NVMMIISSST PPNN-VDDGF PVVVEEEEAL HHLYWDDDWW HHEVVQQLSS WWQPP--RNN NVMMIISSST PPNN-VNNGF PVVVEEEEAL HHLHWDDDWW HHEVVQQLLL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A SSNN-LTTGS DAAASSSSAR IIT------- ---------- LLENNYYAGG GLFFWWSSSW SSLL-FTTGA LLLLTTTTAG IISCDNNNYY RRVDDEELPP WWQPP--RNN NVMMIISSST PPKK-ALLGF MVVVQQQQAM SSLNWDDDWW HHRIIQQIDD WWQPP--RNN NVMMIISSST PPKK-ALLGF MVVVQQQQAH SSLNWDDDWW HHRVVQQIDD WWQPP--RNN NTMMIISSST PPTT-AKKGF LVVVAAAADL HHLTIQQQLL GGERRQQLDD WWQPP--RNN NTMMIISSST PPKK-AQQGF LVVVAAAADL HHLHYSSSWW GGEKKQQLDD WWQPP--RKK KTMMIISSST PPKK-AKKGF LVVVAAAADL HHLHYSSSWW GGEKKQQIDD WWQPP--RKK KTMMIISSST PPKK-AKKGF LVVVAAAADL HHLHYSSSWW GGEKKQQIDD WWQPP--RKK KTMMIISSSS PPAA-ATTGF LVVVQQQQDL HHLHYDDDWW GGEKKQQLDD WWQPP--RNN NVMMIISSST PPNN-HKKGF PVVVGGGGEL SSVHFEEEWW KKKLLQQIDD WWQPP--RNN NIMMIISSST PPNN-HKKGF PVVVPPPPEL SSVHFEEEWW KKKLLQQIDD ---------- ------SSSI PPVV-TRRDE LQQQPPPPEL CCKRY----- ---------- WWQPP--HNN NVMMVVAAAS PPKK-LRRGY PCCCDDDDDQ RRLNYRRRWW RREFFQQIDD WWQPP--YDD DVMMVVSSSS PPNN-KRRGW NLLLEEEEDQ RRLNYKKKWW QQTYYQQIDD HHNGG---EE EKSSEESSSD PPII-MEESS SKKKKKKKTL HHVAVLLL-- ---------- RRLII--RNN NVMMLLTTTS WWSSYMFFGQ LAAAEEEEAR TTIVWDDDLL RRQKKKKFNN RRLPP--RNN NLLLVVTTTS WWNNYMFFGK LPPPEEEEAH TTVVWDDDLL KKQKKKKFDD LLLLEER--- --ELLLLLHD DDPPTTGFFN NNVVVKDLLS SIIWWLWWFF FFYYDGGGGK LLLLQQR--- --EVVLLLHD DDPPTTGFFN NNVVLKDLLS SIIWWLWWFF FFYYDGGGGK LLLLAAQ--- --EVVAAAHD DDPPVVGFFG GGVVVTNLLE SIIWWTWWWW WWRRGGGGGK LLLLAAQ--- --EVVAAAHD DDPPVVGFFG GGVVVTNLLE SIIWWTWWWW WWRRGGGGGK LLLLAAQ--- --EIIAAAHD DDPPSSGFFG GGVVVTNLLQ AIIFFTWWWW WWQQDGGGGT FFFFDDQ--- --ELLAAAHD DDPPTTGFFN NNVVIKDLLS SIIWWTWWYY YYRRKDDDDK LLLLAAQ--- --ELLAAAHD DDPPTTGFFN NNVVVKDLLS SIIWWLWWYY YYRRNGGGGS VVVVEEQ--- --ELLAAAHD DDPPAAGFFG GGVVVEDLLS SVVWWLWWHH HHRRNGGGGS MMMM--G--- LLEIILLLHD DDPPSSGFFG GGAALNIQQR YKKNNEEEGG GG-------- MMMM--G--- LLEIILLLHD DDPPDDGFFG GGAALNIQQR YKKNNEGGGG GG-------- LLLL--G--- LLEIILLLHN NNPPDDGFFG GGAALTIQQR YKKNNQGGGG GG-------- LLLL--G--- LLEIILLLHN NNPPDDGFFG GGAALTIQQR FKKNNEDDGG GG-------- LLLL--G--- LLEIILLLHN NNPPDDGFFG GGAALTIQQR YKKNNEGGGG GG-------- LLLL--G--- LLEIILLLHN NNPPDDGFFG GGAALTIQQR YKKNNEGGGG GG-------- LLLL--G--- LLEIILLLHN NNPPDDGFFG GGAALTIQQR YKKNNEGGGG GG-------- LLLL--G--- LLEIILLLHN NNPPDDGFFG GGAALTIQQR YKKNNEGGGG GG-------- MMMM--G--- LLEIILLLHD DDPPAAGFFG GGAALTIQQR YKKNNEGGGG GG-------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLLL--QNPI LLCLLIIIHW WWKKNNDYYV VVEEVSGRRG SDDPPDAAYY YY-------- LLLLEEG--- LLEIILLLHD DDPPDDGLLG GGAALTVFFR YKKEEKDDGG GG-------- LLLLKKG--- LLEIILLLHN NNPPDDGLLG GGAALSIFFR YKKEEKDDGG GG-------- LLLLNNG--- LLEIILLLHD DDPPAAGFFG GGAALNMIIR FKKTTQDDGG GG-------- LLLLDDG--- LLEIILLLHD DDPPAAGFFG GGAALNMIIR FKKTTQDDGG GG-------- LLLLEEG--- LLEIILLLHD DDPPSSGYYG GGAALNMIIR FKKNNSDDDD DD-------- LLLLPPG--- LLEIILLLHD DDPPSSGFFG GGAALNMIIR FKKNNSDDEE EE-------- LLLLSSG--- LLEVVLLLHD DDPPSSGYYG GGAALNMVVR FKKTTADDGG GG-------- LLLLQQG--- LLEVVLLLHE EEPPTTAFFG GGAALGIFFR HPPVVEEENN NNSS------ LLLLMMG--- LLEVVLLLHE EEPPTTAFFG GGAALAIFFR HPPDDEKKNN NNPP------ ---------- ---------- ---------- ---------- ---------- ---------- LLLLDDG--- LLEIILLLHN NNPPRRGYYG GGAAFXXXXX X--------- ---------- LLLLSSG--- LLEIILLLHN NNPPKKGFFG GGAALKVFFH KKKKKSDDSS SSDD------ ---------- ---------- ---------- ---------- ---------- ---------- VVVVGG---- LLEIIPPPWG GGSSNNAFFT TTAALQLWWL YEEDDDAAGG GG-------- VVVVGG---- LLEIIAAAWG GGEEAACFFS SSAALQLWWL YEEDDGEEGG GG-------- KWNEKKVIEE EPLLEGNLII LKKAPPPPPV VVTIIILKKF FLLWGVVRRR YYYDNNNPPF KWQERRVIDD QPFFEGPLVV LKKMPPPPPV VVTIIILRRF FLLWGLLRRR YYYDNNNPPH KFHKKKTATT EPAATAELLL LQGAPPPPPV VVTILLLRRF FLCWGMMRRR YYYDDDDPPH KFHEKKTATT EPAAPKKLLL LQGAPPPPPV VVTILLMRRF FLCWGMMRRR YYYDDDDPPR TFEKKKTITT VPAADADLLL LKGAPPPPPV VVTILLLKKY YLCWGMMHHH YYYDDDDPPM KWARKKVIEE EAAADPQLVV LKKAPPPPPV VVTILLMRRF FLCWGLLLLL YYYDDDDPPF SWHKKKVIDD EPAASEQLII LKKAPPPPPV VVTILLVRRF FLCWGLLHHH YYYDDDDPPF SWGRKKVIEE EPAAEPQLLL LKGAPPPPPV VVTILLLRRF FLCWGLLRRR YYYDDDDPPF -------TWW KVIIQVSKKK GWPEPGGGGI IITILLLRRF FLNWGIIRRR YYYDNNNPPQ -------TWW KVIIQVSKKK GWPEPGGGGI IITILLLRRF FLNWGIIRRR YYYDNNNPPK -------TWW KVIIQVPKKK GWPEPGGGGI IITILLLRRF FLNWGLLRRR YYYDDDDPPQ -------TWW KVIIQVPKKK GWPEPGGGGI IITILLLHHF FLNWGIIRRR YYYDDDDPPQ -------TWW KVIIQVPKKK GWPEPGGGGI IITILLLRRF FLNWGLLRRR YYYDDDDPPQ -------TWW KVIIQVPKKK GWPEPGGGGI IITILLLRRF FLNWGLLRRR YYYDDDDPPQ -------TWW KVIIQVPKKK GWPEPGGGGI IIT------- ---------- ---------- -------TWW KVIIQVPKKK GWPEPGGGGI IITILLLRRF FLNWGLLRRR YYYDDDDPPQ -------TWW KVIIEVPKKK GWPEPGGGGI IITILLLRRF FLNWGMMRRR YYYDDDDPPK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AVV RKLLDLYAAA KFVSSNNNNF FFPAIIFLLL LIS------- ---------- -------KWW KVIIKVSKEE GWPEPGGGGI IITIIILRRF FLNWGIIRRR YYYDDDDPPR -------KWW KVIIQVSKEE GWPEPGGGGI IITIIILRRF FLNWGIIRRR YYYDDDDTTR -------SWW LAIIPVPLQQ NWPEPGGGGI IITFIILRRF FLNWGIIRRR YYYNDDDLLK -------SWW IVIISVPLQQ NWPEPGGGGI IITFIILRRF FLNWGIIRRR YYYNDDDVVK -------TWW IVIISVPLEE NWPEPGGGGI IITFIILRRF FLNWGIIRRR YYYNDDDPPK -------TWW VVIISVPLEE NWPEPGGGGI IITFIILRRF FINWGIIRRR YYYNDDDPPK -------SWW VAIISIPLRR NWPEPGGGGI IITFIILRRY YLNWGIIRRR YYYNDDDPPA ----TT-THH LVAAFISKSS GWPEPAAAAI IITIIIMRRF FLCWGIIRRR YYYDDDDPPL ----KK-VQQ LVAATISKEE NWPDPAAAAI IITIIIMRRF FLCWGIIRRR YYYDDDDPPK ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------EE NGEMGGGGGM MMTIIILRRY YLNWGVVRRR YYYDDDDRRA ----EEFEAA IDIIPGLVGG SGEDGGGGGI IISIIILRRF FLCWGVVRRR YYYDDDDPPE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----EWAKAA DIPAIPPPPP PPVIIIAQQT TLSFGTTRRR FFFDDDDPPH ---------- ----EWAKAA DIPAVPPPPP PPVIIINSSR RLTFGTTRRR FFFDDDDPPH FKPVVTTTTT KKLLGIRRAA AHP------- -------AGG GHKKLTTTTA QMLLEEISSR HQPRRAAAAA RRIIGLRREE EHP------- -------SGG GAEEATTTTA QMIISSVSSR HNPVVAAAAA SSIIGIRRAA AHP------- -------NGG GRTTFAAAAG QMVVEEISSR RKPKKAAAAA SSIIGIRRTT THP------- -------NGG GKAAFAAAAG QMVVEEISSR MNPVVTTTTT KKIIGIKKTT THP------- -------NGG GKTTFGGGGG QMVVEEISSR FEPKKTTTTT KKIIGIRRAA AHP------- ------AKNN NGAALNNNNG QMVVEEISSR FNPRRTTTTT KKIIGIRRAA AHP------- ------ATSS SAEELNNNNG QMVVEEISSR FNPRRTTTTT SSLLGIKKAA AHP------- -------ASS SGPPLNNNNG QMVVEEVSSR QKPRRTTTTT QQLLGSRRGG GSVV--QTTQ QQPPLLVKGG GKRRIPPPPG QMIIQQLSSL KKPRRTTTTT QQLLGSKKGG GSVV--QTTQ QQPPLLVKGG GKRRVPPPPG QMIIQQLSSL QRPRRTTTTT QQLLGSKKGG GPVV--QKKQ QQPPLLVKGG GKKKVPPPPG QMIIQQLSSL QRPRRTTTTT QQLLGSKKDD DPVV--QDDQ QQPPLLVKGG GKQQVAAAAG QMIIQQLSSL QRPRRTTTTT QQLLGSKKGG GPVV--QKKQ QQPPLLVKGG GKRRVAAAAG QMIIQQLSSL QRPRR----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QRPRRTTTTT QQLLGSKKGG GPVV--EKKQ QQPPLLVKGG GKRRVAAAAG QMIIQQLSSL KRPRRVVVVV QQLLGSKKGG GPVV--QKKQ QQPPLLVKGG GKRRVPPPPG QMIIQQLSSL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RNPKKVVVVV QQLLGSRRGG GPVV--KEEQ QQPPVVVKGG GKKKVPPPPG QMIIQQLSSL RNPKKVVVVV QQLLGSRRGG GPVV--KEEQ QQPPVVVKGG GKIIIPPPPG QMIIQQLSSL KNPVVTTTTT QQVVGLKKGG GPVA--DTTQ QQSVPPIQGG GQKKLRRRRG QMIIQQLTTL KNPKKTTTTT QQAAGLKKGG GPVA--DTTQ QQSVPPIQGG GKKKLRRRRG QMIIQQLSSL KNPVVTTTTT QQVVGLKKGG GPVA--DSSQ QQFVPPIKGG GKSSLRRRRG QMIIQQLSSL KNPVVTTTTT QQVVGLKKGG GPVA--DTTQ QQFVPPIKGG GKSSLRRRRG QMIIQQLSSL AKPVVAAAAA QQAAGLKKGG GEVY--DEEQ QQYVPPVKGG GHRRLRRRRG QMIIQQLSSL LKVKKNNNNN QQIIGSTTEE ENVV--E--P PPIALLVKGG GRKKIEEEEG QMLLQQLSSL KNPKKNNNNN QQIIGSSSEE ETVV--D--E EEIALLVKGG GRQQIEEEEG QMLLQQLSSL ---------- ---------- ---------- ---------- ---------G AKIIQQLSSV ANPRRTTTTT QQLLGARRDD DPRV--PKKA AAPPVVLKGG GRRRLLLLLG QMLLQQLSSL ENPKKTTTTT QQLLGASSDD DPNIEEKKKR RRPARRVKGG GRRRLEEEEG QMLLQQLSSL ---------- ---------- ---------- ---------- ---------- ---------- HKPFFIIIII EEIIRQ---- ---------- ---------- ---------- -MVVSSQSSW HHPRRVVVVV EEIIAQ---- ---------- ---------- ---------- -MVVSSSSSW GGRRVVVNNS LYYYSWWEGK WWMMKL-SGG EIDKKEEFFD DARSSHGGDD AAASYCYPP- GGRRVVINNS LYYYSWW-GR WWMMKV-EGG ELEKKEEFFD DARAAHGGDD AAASFCYPP- GGRRVVWNNS LYYYSWWDGP AAQQLA-DGG TLADDDDYWE EYRAAHGGDD CCCSFCYPPS GGRRVVWNNS LYYYSWWDGP VVEEMA-NGG ELDKKDDYFS SYRAAHGGDD CCCSFCYPPS GGKRVVWNNS LYYYSWWGDG AAMMMA-NGG TLDKKDDFWD DYRSSHGGDD CCCSFCYPPS GGRRVVFNNS LYYYGVVEGD WWMMKL-NGG EFDPPKKFFE EHRPPHGGDD CCCSYCYPP- GGRRVVFNNS LYYYRWWDGK WWMMKV-DGG QFDPPNNFFD DQRVVHGGDD AAASYCFPP- GGRRVVFNNS LYYYAWWVGR WWIIKA-GGG SLDPPGGFFE ELRPPHGGDD SSSSYCYPPS GGKRLLATTS LYYYSWWPDI EEGGVMDNGG KLNPPNNFLD DALAAHGGDD CCCIWI---- GGKRLLVTTS LYYYSWWPNI EEGGVMDNGG KLNPPNNFLD DALAAHGGDD CCCIWI---- GGKRLLVTTS LYYYSWWPDI EEGGVMDKGG KLNPPNNFLD DALAAHGGDD CCCIWL---- GGKRLLVTTS LYYYSWWPDI EEGGVMDKGG TLNPPNNFLD DALAAHGGDD CCCIWL---- GGKRLLITTS LYYYSWWPDI EEGGVMDKGG KLNPPNNFLD DALAAHGGDD CCCIWI---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGKRLLITTS LYYYSWWPDI EEGGVMDKGG KLNPPNNFLD DALAAHGGDD CCCIWI---- GGKRIIVTTS LYYYSWWPDI EEGGVMDKGG KLNPPNNFLD DALAAHGGDD CCCIWL---- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGKRLLVNNS LYYYSWWPDI EEGGVMDKGG KLNPPNNFLD DVLAAHGGDD CCCIWV---- GGKRIIVSSS LYYYSWWPDL EEGGVMDKGG KLNPPNNFLD DVLAAHGGDD CCCIWI---- GGKRLLVNNS LFFFSWWPGV KKGGHIDKGG KINPPNNFFD DALAAHGGDD CCCIWI---- GGKRLLVNNS LFFFSWWPKV QQGGHIDNGG KINPPNNFFD DSLAAHGGDD CCCIWI---- GGKRLLANNS LFFFSWWPEM KKGGHIDKGG SINPPNNFFD DALAAHGGDD CCCIWI---- GGKRLLANNS LFFFSWWPEM KKGGHIDKGG TINPPDDFFD DSLAAHGGDD CCCIWI---- GGKRIIVNNS LFFFSWWQDV KKGGHMDKGG SINPPNNFFD DSLAAHGGDD CCCIWI---- GGKRLLVTTS LYYYKWWPEV SSGGTMDSGK EINRRDDFLD DYLAAHGGDD CCCIWI---- GGKRLLVTTS LYYYKWWPEV SSGGTMDTGH VINKKNNFLD DYLAAHGGDD CCCIWI---- GGKRLLVNNS FYYYSWWPNV EEGGVMDKGG TVNKKNNFLD DCLAAHCCDD SSSILA---- GGRRLLVSSS LFFFSWWPEV AAGGTIDNGG KLNEENNFLD DGLPPH---- ---------- GGKRLLVSSS LYYYSWWPKV QQGGHIDNGG SLNEEDDFLD DSLPPHGGDD CCCIWLANND ---------- ---------- ---------- ---------- ---------- ---------- GGKRVVFSSS LLLLAWW--- KKGGDDAWDG ELVEEDDFAD D-RAAHSSAA LLL------- GGQRLLYSSS LLLLAWW--- KKGGDDLWDG ELKEEQQFAD D-RPPHAAAA LLLPAGDGGN ------- ------- KR----- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LVAAEEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158NAAKKKPPPS SEATPRRTAP GGLLTAAAAR LLLLRTAALS LTTPVRIAAY QEAAAWTTTF gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------M AGSSSAPPPT gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SAAQQQQSRR RESSKGKTRR SPPPGEESSK VPPAAAAQWW WLLPPPKKHH GAAVVLAPAR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---AAAAAEE GFFTTLSVAQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GLLGGGEEPP GTTAAQWFLS ---------- ---------- ---------- --------LL NSSQQQLLGG FQQTTNELHT ---------- ---------- ---------- ---------- ---------- ---------- PPPNNNNPHH HNPPLAASPP PPPPRLLRLY INNRRRRPCC HAARRRLLVV LHHIIMGAAA ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----MTVLD ---------- ---------- ---------- ---------- ---------- -----MTVLQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MMKKKEEFF G--------- ---------- ---------- ---------- ---------- -MMKKKIIVV SPPSSMFALR --------MM AIVVVKKRDP PPTTFFKAAA APPLAAAACC YYTTTGGTGG NDFIAAVVVD ---------- -MAAAKKPDP PPTTFFRAAA APPIAAAAAA YYVVVGGTGG NDFLAAVVVD ---------- --MMMRRPDP PPTTFFEAAA APAFALLLLL SSPPPDDFSS -DALAAVIID ---------- --MMMRRPDP PPTTFFKAAA APAFALLLLL SSPPPDDFSS -DALAAVIID ---------- --MMMRRPDP PPTTFFKAGG GPVLALLLMM SSPPPDDASS -DGLAAVVVD ---------- -MAAAKKPDP PPSSFFRAAA APPIAAAAMM DDPPPEERKK -DAIAAVVVD ---------- -MVVVRRPDP PPTTFFRAAA APALAVVVRR NNPPPMMANN -DAMCCVVVD ---------- -MAAARRPDP PPTTFFKAAA APRLGAAALL DDPPPGGREE -DALGGVLLD -------MTT KCTTT--CGP PPGGYYEMGG GPRIVPPPCC YYRRRNNTGG EDYLAATVVD ---------- ---------- --------GG GPRIVPPPCC YYRRRNNTGG EDYLAATVVD GLPPP-AHTT QCGGG--CGP PPGGYYEMGG GPRIVPPPCC YYGGGNNTGG EDYLAATVVD ---------- ---------- -------MGG GPRIIPPPCC YYRRRNNTGG EDYLAATVVD -------MTT KCGGG--CGP PPGGYYEMGG GPRIVPPPCC YYRRRNNTGG EDYLAATVVD PRPPPASTTT KCGGG--CGP PPGGYYEMGG GPRIVPPPCC YYRRRNNTGG EDYLAATVVD -------MTT KCGGG--CGP PPGGYYEMGG G--------- ---------- EDYLAATVVD -------MTT KCGGG--CGP PPGGYYEMGG GPRIVPPPCC YYRRRNNTGG EDYLAATVVD GLWWWEDTTT KCGGG--CGP PPGGYYEMGG GPRIVPPPCC YYRRRNNTGG EDYLAATVVD YTLLLFTSTT KCGGG--CGP PPGGYYEMGG GPRIVPPPCC YYRRRNNTGG EDYLAATVVD -------MTT KCGGG--CGP PPGGYYEMGG GPRIVPPPCC YYRRRNNTGG EDYLAATVVD VTAAAAANKK TCCCCAAKGP PPGGYYEMGG GPRLVTTTCC YYNNNGGTGG NDYLAATVVD ---------- ---------- ---------- ---------- ---------- ---------- --------AA KCGGG--CGP PPGGYYDMGG GPRIVPPPCC YYRRRSSTGG NDYLAATVVD HVVVVEKK-- VNGGGKKSGP PPGGYYEMGG GPRLITTTAA YYAAAGGTGG EDYLAATVVD HVVVVEKVNN QQGGGKKSGP PPGGYYEMGG GPRLITTTAA YYAAAGGTGG EDYLAATVVD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -RMMMVVGGP PPGGYYAMGG GPSLITTTAA YYTTTGGTGG DDYLAATVVD -MAAAAANAA ACCCCAATGP PPGGYYEMGG GPRLLTTTCC YYNNNGGTGG NDYLGGTVVD --MMMPNCLL KCHHH---GP PPGGYYDIGG GPRVLTTTAA -------NAA DDAIFFTVVD --MMM--CLL KCHHH---GP PPGGYYDIGG GPRVLTTTAA -------HAA DDAIFFTVVN ---------- ---------- ---------- ---------- ---------- ---------- --------MM SESSSKKCGP PPGGYYDVGG GPVLLVVVCC QQPPPNNLDD EDYLAATVVD ---------- ---------- -------MGG GPRLLVVVTT QQPPPNNLDD PDYLSSTVVD ---------- --------MP PPGGLLDLLL LDDLYNNNWW HHGGGDDIRR YTDRKKNPPR AAAAA-ALMM GLPPPAAFAD DDEETTYPTT TGQFVWWWTT GGVVVEEGMM DDKLVVTIID AVSSSLALLL AAPPPVVRAD DDEETTYKTT TGQYVWWWTT GGAAAEEGVV DDKLVVTVVD VNPPPKKSST YIVVHHVVEE PPYIIIDEHF WWNAACSCCP ---KPNERRR IVLLLRSSSR VDPPPKKSST YVIIYYLLDD PPYIIIDEHF WWNAACSCCP ---KPFERRR IVLLLRSSSR VKPPPGGSST YIVVHHVVTT PPNTTTDEHF WWNAACSSSP GGGHAFERRR IILLLRSSSR VKPPPGGSST YIVVHHVVTT PPNKKKDEHF WWNAACSSSP GGGHAFERRR IILLLRSSSR VDPPPTTSSK FIVVHHLLII PPNKKKDEHF WWNAACSSSP GGGHAFERRR IIIIIRSSSR VDPPPAASSR YIVVGGVVAA PPHAAADEHF WWNAACSCCP PPPHPHERRR VVLLLRSSSR VDSSSQQSST FVVVGGTTDD PPYTTTGEHF WWNAACSCCP PPPHPHERRR VVIIIRSSSH LDPPPDDSST YIVVGGVVEE PPNAAADEHF WWNAACSCCP PPPHPHERRR IVIIIRSSSR VDPPPKKSSQ YVIIHHLLPP PPYLLLDEHS WWNTTCS--- GGGDSTSRNN ILLLLMSSSR VDPPPKKSSH YVIIHHLLPP PPHLLLDEHS WWNTTCS--- GGGDSTSRDD ILIIIISSSR IDPPPKKSSQ YVIIHHLLPP PPNLLLDEHS WWNAACS--- GGGDSTSRTT MLLLLMSSSR VDPPPKKSSQ YVIIHHLLPP PPHLLLDEHS WWNTTCS--- GGGDITARTT VLLLLISSSR VDPPPKKSSQ YVIIHHLLPP PPNLLLDEHS WWNTTCS--- GGGDSTSRTT VLLLLISSSR VDPPPKKSSQ YVIIEE---- ---------- ---------- ---------- ---------- VDPPPKKSSQ YVIIHHLLPP PPNLLLDEHS WWNTTCS--- GGGDSTSRTT VLLLLISSSR VDPPPKKSSQ YVIIHHLLPP PPNLLLDEHS WWNTTCS--- GGGDSTSRTT VLLLLISSSR VDPPPKKSSQ YVIIHHLLPP PPYLLLDEHS WWNTTCS--- GGGDSTSRNN VLFFFISSSR VDPPPKKSSQ YVIIHHLLPP PPNLLLDEHS WWNTTCS--- GGGDSTSRTT VLLLL----- VDPPPKKSSQ YVIIHHLLPP PPNLLLDEHS WWNTTCS--- GGGDSTSRTT VLLLLISSSR LDPPPSSSST YVIIHHLLPP IIHIIIDKHS WWNSSCS--- GGGDPSKRRR ILLLLLSSSR ---------- ---------- PPNTTTDEHS WWNTTCS--- GGGDASVRNN ILLLLISSSR VDPPPKKSSS YVIIHHLLPP PPNVVVDEHS WWNTTCS--- GGGDSSVRNN ILLLLISSSR VDPPPSSSST YVIIHHLLPP PPYVVVDEHT WWNSSCS--- GGGDPSERRR IALLLVSSSR LDPPPNNSST YVIIHHLLPP PPYVVVDEHT WWNSSCS--- GGGDPSQRRR IVIIIVSSSR ---------- ---------- PPFVVVDEHS WWNSSCS--- GGGDASDRRR VLLLLISSSR VDPPPSSSSS YVIIHHLLPP PPFVVVDEHS WWNSSCS--- GGGDASDRRR VLLLLISSSR VDPPPNNSST YVIIHHLLPP TTHVVVDEHS WWNAACS--- GGGDPSSRRR ILLLLLSSSR VNPPPEESST FVIISSVVDD PPHIIIDEHT WWNAACS--- DDDKPTKRSS IVLLLNSSSR VNPPPEESST FIIISSVVDD PPNIIIDEHT WWNAACS--- DDDKPTKRSS IVLLLNSSSR ---------- ---------- ---------- ---------- ---------- VPLLLSSSSV VDPPPAASST YVIIHHTTYY NNSKKKNEHS WWNTTCSFFP GGGKEVTRDD VLLLLNSSSR VDPPPEESST YIVVHHTTFF NNRKKKDEHS WWNAACSYYD SSSKTVKRDD VLLLLNSSSF MVGGGQQVVL GVLLKKGGPP KKVLLLDKDS PPTPPRI--- GGGKRVGGPP LQLLLDGGGR LRPPPGGSST RVIINNVVSS GGG---NEHG FFSAA----- ------DRRR WTLLLDTTTR ANPPPKKSSQ YVVVNNLLSS GGG---NEHS FFTDD----- ------DRRR WALLLDTTTK RIIIIIYIII IIIDKNPREE EPKKEEPEEE VKKKYYYYYY YLHVHCGGGG PAAAAIIYYS RIIIIIYIII IIIDKDKRRR RPAKEEPEEV AVGGYYYYYY YYHVHCGGGG PAAAAIIYYS RIIIIIYVVV VVVDKHPTQQ QARKEEPDDE ILAAYYYYYY YPHVHCGGGG PGGGGIIYYS RIIIIIYIII IIIDKDPTKK KAKKEEPEEE VFKKYYYYYY YPHIHCGGGG PGGGGIIYYS RIIIIIYIII IIIDKEPLKK KAKKEEPEEE VFAAYYYYYY YPHIHCGGGG PGGGGIIYYS RIIIIIYIII IIIDKDPLKK KPFKEEPEET LAEEYYYYYY YPHVHCGGGG PGGGGIIYYT HIIIIITIII IIIDKDPTQQ QPKKDDPNNE LAEEYYYYYY YPHVHCGGGG PGGGGIIYYS RIIIIIHIII IIIDKDPREE EPRKEEPEEE LHRRYYYYYY YPHIHCGGGG PGGGGVVYYS RIIIIIYVVV VVVDGEPRAA APKKEEASSE IQAAVVVVVV VTHSHCLLLL AGGGGEEVVV RIIIIIYVVV VVVDGEPRAA APKKEEPNNE IHAALLLLLL LLHSHCLLLL AGGGGEEVVI RIIIIIYVVV VVVDGDPRAA APKKEEAEED IHAALLLLLL LVHSHCLLLL AGGGGEEVVI RIIIIIYVVV VVVDGEPRAA APKKEEPKKD IHTTLLLLLL LFHSHCLLLL PGGGGEEVVV RIIIIIYVVV VVVDGEPRAA APKKEEPEED IHAALLLLLL LLHSHCLLLL AGGGGEEVVI ---------- ---------- ------PKKD IHAALLLLLL LLHSHCLLLL AGGGGEEVVI RIIIIIYVVV VVVDGEPRAA APKKEEPKKD IHAALLLLLL LLHSHCLLLL AGGGGEEVVI RIIIIIYVVV VVVDGEPRAA APKKEEPKKD IHAALLLLLL LLHSHCLLLL AGGGGEEVVI RIIIIIYVVV VVVDGEPRAA APKKEEAKKD IHEELLLLLL LPHSHCLLLL PGGGGEEVVI ---------- ---------- ---------- ---------- ---------- ---------- RIIIIIYVVV VVVDGEPRAA APKKEEPKKD IHAALLLLLL LLHSHCLLLL AGGGGEEVVI RVVVVVYVVV VVVDADPRTT TPSKEESEED IAEELLLLLL LPHSHCLLLL AGGGGDDIII RIIIIIYVVV VVVDGDPRAA APRKEEPYYE VFWWLLLLLL LLHSHCLLLL GGGGGEEIII RIIIIIYVVV VVVDGDPRAA APRKEEPYYE VFWWLLLLLL LPHSHCLLLL GGGGGEEIII RIIIIIYVVV VVVDKNPRSS SPSKDDPAAD IIQQLLLLLL LPHSHCLLLL AGGGGEELLI RVVVVVYVVV VVVDKNPRAA APSKEEPEED ISTTLLLLLL LPHSHCLLLL AGGGGEEIII RIIIIIYAAA AAADKNPRAA APSKDDPKKE IAEELLLLLL LPHAHCLLLL AGGGGEEIIV RIIIIIYAAA AAADKNPRAA APSKDDPKKE IADDLLLLLL LPHAHCRRRR TGGGGEEIIV RVVVVVYVVV VVVDLDPRAA APAKEEAEED IAEELLLLLL LPHSHCLLLL AGGGGEEIII RIIIIIYIII IIINEE-RKK KIYHEEPSSK LHSSLLLLLL LPHSHCLLLL AGGGGNNIII RIIIIIYVVV VVVNEE-REE EIYHEEPSSK LHAALLLLLL LPHSHCLLLL AGGGGNNIII VEEEEEGKKK KKKFG----- ---------- ---------- ---------- ---------- RIIIIIFVVV VVVDGDPRAA APKKEEG--D VLKKCCCCCC CPHTHCLLLL PGGGGNNIII FIIIIIYIII IIIDVDPRKK KPEKDDG--D VLKKVVVVVV VPHTHCLLLL AGGGGNNIII RLLLLLYVVV VVVTLSAWDD DKQP-----D LIKKLLLLLL LSHADYQQQQ PTTTTAALLQ RIIIIIFIII IIIDHDPSNN NPKKDDT--F VKDDVVVVVV VPHFFALLLL PSSSSMMMMT KIIIIIFVVV VVVDHDPARR RPVKTTD--F VEKKVVVVVV VPHLYALLLL PRRRRMMLLT SALGE---EE EGGIILLMLD DHYYYSELGG IDRD------ ---------L LDFFNLL-PE SALGP---DD EGGIIFFLLD DHDDDTEIGG VYRP------ ---------F FDFFNLL-PG STLGAGGGDD DPPIIFFIMD DCEEETDLGG IDRP------ ---------K KDFFNLL-PD STLGGGGGDD NPPVVFFIMD DCEEETELGG IDRP------ ---------L LDFFNLL-PD STLGGGGGDD DPPIIFFILD DCEEETELGG MDRE------ ---------K KDFFNLL-PD TALGA---EE KGGIIAAMLD DAQQQSELGG VERP------ ---------F FDGGHLL-GD SALGP---EE EGGIIFFILD DHDDDNELGG IDRD------ ---------L LDFFHLL-GD SALGP---EE DGGVVFFVMD DHEEESDLGG VERP------ ---------L LDFFHLL-GD VNTLD---LL NGGFFVVLLD DGEEETEKGG KPGA------ ---------M MDFFQPP-RN ISSLD---PP NGGFFVVLLD DGEEETEKGG KPGE------ ---------M MDFFQPP-RN ISTLD---SS NGGFFVVLLD DGEEETEKGG QPGA------ ---------M MDFFQPP-RN VSTLD---PP NGGFFVVLLD DGKKKTEKGG QPGA------ ---------L LDFFQPP-RN ISSLD---VV NGGFFVVLLD DGEEETEKGG RPGA------ ---------S SDFFQPP-RN ISSLD---VV NGGFFVVLLD DGEEETEKGG RPGA------ ---------L LDFFQPP-RN ISSLD---VV NGGFFVVLLD DGEEETEKGG RPGA------ ---------L LDFFQPP-RN ISSLD---VV NGGFFVVLLD DGEEETEKGG RPGA------ ---------L LDFFQPP-RN ISTLD---PP NGGFFVVLLD DGEEETEKGG RPGS------ ---------M MDFFQPP-RN ---------- ---------- ---------- ---------- ---------- ---------- ISSLD---VV NDDSSLLVLL LP---RESGG ---------- ---------- ---------- ISCLD---KK NGGGGFFLLL LDSSSENKGG NRLP------ ---------K KTHHENNYAG ISSID---PP NGGFFVVLLD DGEEETEKGG AEGA------ ---------F FDFFQPP-RN ISSLD---PP NGGFFVVLLD DGEEETEKGG VEGS------ ---------F FDFFQPP-RN ISCLD---KK NGGGGFFLLL LDSSSDNKGG KPGS------ ---------F FDFFQPP-RN ISCID---KK NGGGGFFLLL LDSSSENKGG KPGS------ ---------F FDFFQPP-RN VSCLD---EE NGGGGFFLLL LDSSSDNKNN KPGS------ ---------F FDFFQPP-RK VSCLD---EE NGGGGLLLLL LDSSSDNKNN KPDS------ ---------Y YHFFQPP-RK ISCLD---KK NGGGGFFLLL LDSSSENKGG KPGS------ ---------F FDYYQPP-RK ISTLE---AA TGGFFLLLLD DGKKKTEKGG ADET------ ---------F FDFFQPP-RN ISTLE---AA SGGFFLLLLD DGKKKTEKGG ADGV------ ---------F FDFFQPP-RN ---------- ---------- ---------- ---------- ---------- ---------- ISIMD---AA NGGDDFFVEF FDKKKNEVGG RGDK------ ---------C CDYYQPP-HN ISVMD---AA YGGDDFFILF FDSSSDNIGG KGDK------ ---------C CDFFQPP-YD QDGVE---SS VLLGGIIQTS SKHHHEGSAA ASQE------ ---------L LSNNNGG--E TGLSD---DD GTTLLVVEYN NDDDDGYATT PTADGGAAAV GDDAAAVVDY YDIILII-RN TGLSN---KK GTTLLVVEYT TNAAAGYATT PTDDGGAAAI G--KKKYYDY YDVVLPP-RN VVLVVSVPN- --ED--LKLE EHHKKKKKK- YGIIIHHFLK RIHTTGEERR MMA------E VVMIITVPR- --EE--FSLE ECCKKKKKKG YGLLLHHVLR HLYDDGQERR MMV------E YYMVVSLPP- --EN--IVPE EDDLLLLLLN YGLLLHHFLR NVQDDGAQQQ MMA------E YYMVVTLPP- --EN--IVPE EDDLLLLLLN YGLLLHHFLR NVQDDGANQQ MMA------E YYMVVSLPP- --EN--IVPE EDDLLLLLLN YGIIIHHFLK NVQDDGANQQ MMA------E TTLVVTTPD- --ED--LVPD DIILLLLLLA YGLLLHHFLR HLQDDGDEQQ LLV------E TTLLLTTPR- --ES--VLGD DEELLLLLLG YGLLLHHVLR HLQDDGAEQQ MMA------E TTMVVTTPN- --EG--LDPQ QIILLLLLLK YGLLLHHILR HLQDDGEEQQ MMV------E VVMVVSAPN- --KDFFNPAH HVVAAAAAAG YGIIIFFVWE IIQQQT--GG LLI-----LE IIMVVSAPN- --KDFFNPAH HVVAAAAAAG YGIIIHHVWE IIQQQK--GG LLI-----LE VVMIISAPN- --RDFFNPAD DVVAAAAAAG YGLLLHHVWE IIQTTQ--GG LLI-----LE VVMIISAPN- --RDFFNPAD DVVAAAAAAG YGLLLYYVWE IVQPPQ--GG LLI-----LE VVMIISAPN- --RDFFNPAD DVVAAAAAAG YGLLLYYVWE IVQSSK--GG LLI-----LE VVMIISAPN- --RDFFNPAD DVVAAAAAAG YGLLLYYVWE IVQSSK--GG LLI-----LE VVMIISAPN- --RDFFNPAD DVVAAAAAAG YGLLLYYVWE IVQSSK--GG LLI-----LE VVMIISAPN- --RDFFNPAD DVVAAAAAAG YGLLLYYVWE IVQSSK--GG LLI-----LE VVMIISAPN- --QNFFNPAD DVVAAAAAAG YGLLLHHVWE IVQLLP--GG HHI-----LE ---------- ---------- ---------- ---------- ---------- ---------- ------HSN- --LTSSRDYP PAAAAAAAAS VATTT----- ---------- ---------- LLFWWSCSL- --TTAAELMC CLLAAAAAAS VHSSSCCLYV IDEPPQ--QQ AAGNNPPILC VVMIISAPK- --ALFFKMEE EVVAAAAAAG YGLLLNNVWR RIQDDGE-GG LLI-----LE VVMIISAPK- --ALFFKMED DVVAAAAAAG YGLLLNNVWR LVQDDGK-GG LLI-----LE TTMIISAPT- --TKFFDLQH HVVDDDDDDG YGLLLTTCLE LRQDDGN-GG LLL-----LE TTMIISAPK- --LQFFNLQH HVVDDDDDDG YGLLLHHVWE IKQDDGD-GG LLL-----LE TTMIISAPK- --SKFFDLQH HVVDDDDDDG YGLLLHHVWE MKQDDGE-GG LLL-----LE TTMIISAPK- --SKFFNLQH HVVDDDDDDG YGLLLHHVWE IKQDDGP-GG LLL-----LE TTMIISAPA- --RTFFDLQH HVVDDDDDDG YGLLLHHVWE LKQDDGS-GG LLL-----LE VVMIISSPN- --KKFFNPAH HVVEEEEEEG YGVVVHHIWK YLQDDPQPGG AAL-----LE IIMIISSPN- --KKFFNPAH HVVEEEEEEG YGVVVHHIWK HLQDDPMPGG AAL-----LE -----SGPV- --CREEELKC CQQEEEEEEP VIKKKRRV-- ---------- ---------- VVMVVAAPK- --RRYYHPTD DCCDDDDDDT YGLLLNNFWE LFQDDGD-GG LLT-----LE VVMVVSAPN- --RRWWKNVD DLLDDDDDDS YGLLLNNFWT LYQDDGS-GG IIT-----LE KKSEESEPI- --FESSESFL LKKTTTTTTP KPVVVAAE-- ---------- ---------- VVMLLTGWSN NYDFQQMLQD DAAAAAAAAK FGIIIVVQLQ PKKNNPGA-- --------LE LLLVVTGWNN NYDFKKMLAD DPPAAAAAAK FGVVVVVTLQ PKKDDPGA-- --------LE ELLLLDPPKL LMFINMMVVL KKKDDDLSSS SIWWLLEKKE KKVIEIIIPE LLLEE-PPPP EVVLLDPPKL LMFVNVVLLT KKKDDDLSSS SIWWLLEKKE RRVIDIIIEQ FFFEE-PPPP EVVAADPPRE EYFVGVVVVT TTTNNNLEEG SIWWTTEKKK KKTATIIIPE AAATTDPPPP EVVAADPPRE EYFVGVVVVT TTTNNNLEEA SIWWTTEKKE KKTATIIIPE AAAPPEPPPP EIIAADPPKD DYFCGVVVVT TTTNNNLQQG AIFFTTDTTK KKTITIIIDV AAADDDPPPP ELLAADPPKA AYFVNCCIIL KKKDDDLSSS SIWWTTDKKR KKVIEIIIPE AAADDDPPPP ELLAADPPKA AYFMNCCVVL KKKDDDLSSA SIWWLLDSSK KKVIDIIIPE AAASSDPPPP ELLAADPPRT TYFVGVVVVL EEEDDDLSSA SVWWLLQSSR KKVIEIIIPE AAAEEDPPPP EIILLDPPAT TQFVGCCLLS NNNIIIQRRF YKNNEE---- ---TWSSSVK IIIQQPKKKK EIILLDPPAT TQFVGCCLLS NNNIIIQRRF YKNNEE---- ---TWSSSVK IIIQQPKKKK EIILLNPPAA AQFVGCCLLS TTTIIIQRRF YKNNQQ---- ---TWSSSVK IIIQQPKKKK EIILLNPPAA AQFVGCCLLS TTTIIIQRRF FKNNEE---- ---TWSSSAK IIIQQPKKKK EIILLNPPAA AQFVGCCLLS TTTIIIQRRF YKNNEE---- ---TWSSSVK IIIQQPKKKK EIILLNPPAA AQFVGCCLLS TTTIIIQRRF YKNNEE---- ---TWSSSVK IIIQQPKKKK EIILLNPPAA AQFVGCCLLS TTTIIIQRRF YKNNEE---- ---TWSSSVK IIIQQPKKKK EIILLNPPAA AQFVGCCLLS TTTIIIQRRF YKNNEE---- ---TWSSSVK IIIQQPKKKK EIILLDPPAS SQFVGCCLLS TTTIIIQRRF YKNNEE---- ---TWSSSVK IIIEEPKKKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CLLIIWKKIN NQYDVVVVVF SSSGGGRGGG SDPPDD---- ---AVVVVLR LLLDDYVVVV EIILLDPPAA AQLVGCCLLS TTTVVVFRRF YKEEKK---- ---KWAAAAK IIIKKPKKKK EIILLNPPAD DQLVGCCLLS SSSIIIFRRF YKEEKK---- ---KWAAAAK IIIQQPKKKK EIILLDPPKD DTFVGSSLLS NNNMMMIRRF FKTTQQ---- ---SWSSSHL IIIPPKKKKK EIILLDPPKD DTFVGSSLLS NNNMMMIRRF FKTTQQ---- ---SWNNNHI IIISSEKKKK EIILLDPPKD DTYVGSSLLS NNNMMMIRRF FKNNSS---- ---TWSSSYI IIISSKKKKK EIILLDPPKD DTFVGSSLLS NNNMMMIRRF FKNNSS---- ---TWSSSHV IIISSKKKKK EVVLLDPPKD DTYVGCCLLS NNNMMMVRRF FKTTAA---- ---SWSSSHV IIISSKKKKK EVVLLEPPSE EHFVGCCLLS GGGIIIFRRI HPVVEE---- TT-THAAAAL AAAFFPKKKK EVVLLEPPSE EHFVGCCLLS AAAIIIFRRI HPDDEE---- KK-VQTTTAL AAATTPKKKK ---------- ---------- ---------- ---------- ---------- ---------- EIILLNPPEN NQYVGCCFFX XXXXXXXXXX X--------- ---------- ------QQQQ EIILLNPPKA AEFVGCCLLA KKKVVVFHHF KKKKSS---- EEFEAKKKKI IIIPPKDDDD ---------- ---------- ---------- ---------- ---------- ---------- EIIPPGSSAN NYFSTTTLLS QQQLLLWLLI YEDDDD---- ---------- ---EEQAAAA EIIAAGEEHN NYFTSTTLLS QQQLLLWLLI YEDDGG---- ---------- ---EEQAAAA EEIILKFAVV PPPVTTDDII SLDDDDKKKF FYYLLSLLLL WWWIIGGEVR QYDISFFFKK PPVVLKFMVV PPPVTTDDII SLDDDDRRRF FYYVVSLLLL WWWLLGGELR QYDITHHHQQ PPLLLQFAVV PPPVTTDDLL SLDDDDRRRF FYYVVSCCCC WWWTTGGEMR QYDVSHHHNN PPLLLQFAVV PPPVTTDDLL SMDDDDRRRF FYYVVSCCCC WWWTTGGEMR QYDVSRRRKK DDLLLKFACC PPPVTTDDLL SLDDDDKKKY YYYVVACCCC WWWLLGGEMH QYDVSMMMNN PPVVLKFAVV PPPVTTDDLL SMDDDDRRRF FYYVVSCCCC WWWTTGGDLL QYDVSFFFEE PPIILKFAVV PPPVTTNNLL SVDDDDRRRF FYYVVSCCCC WWWTTGGELH QYDVSFFFNN PPLLLKFAVV PPPVTTNNLL SLDDDDRRRF FYYVVSCCCC WWWTTGGELR QYDVSFFFNN VVKKGWLEMM PPGITTLLLL SLDDDDRRRF FYYFFSNNNN WWWHHGGDIR QYDISQQQKK VVKKGWLEMM PPGITTLLLL SLDDDDRRRF FYYFFSNNNN WWWHHGGDIR QYDISKKKKK VVKKGWLEMM PPGITTLLLL SLDDDDRRRF FYYFFSNNNN WWWHHGGDLR QYDISQQQRR VVKKGWLEMM PPGITTLLLL SLDDDDHHHF FYYFFSNNNN WWWHHGGDIR QYDVSQQQRR VVKKGWLEMM PPGITTLLLL SLDDDDRRRF FYYFFSNNNN WWWHHGGDLR QYDISQQQRR VVKKGWLEMM PPGITTLLLL SLDDDDRRRF FYYFFSNNNN WWWHHGGDLR QYDISQQQRR VVKKGWLEMM PPGITT---- ---------- ---------- ---------- ---------- VVKKGWLEMM PPGITTLLLL SLDDDDRRRF FYYFFSNNNN WWWHHGGDLR QYDISQQQRR VVKKGWLEMM PPGITTLLLL SLDDDDRRRF FYYFFNNNNN WWWHHGGDMR QYDISKKKRR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- VVAAKFVSLL SSNFPPWWII FFSSSDLLLL LIIFFLSSSS ---------- ---------- VVEEGWLEMM PPGITTLLII SLDDDDRRRF FYYFFSNNNN WWWHHGGDIR QYDITRRRNN VVEEGWMEMM PPGITTLLII SLDDDDRRRF FYYFFSNNNN WWWHHGGDIR QYDITRRRNN VVQQNWLEMM PPGITTLLII SLDDDDRRRF FYYFFVNNNN WWWHHGGDIR QYNIEKKKNN VVQQNWLEMM PPGITTLLII SLDDDDRRRF FYYFFVNNNN WWWHHGGDIR QYNIEKKKNN VVEENWLEMM PPGITTLLII SLDDDDRRRF FYYFFVNNNN WWWHHGGDIR QYNIEKKKNN VVEENWLEMM PPGITTLLII SLDDDDRRRF FYYFFVNNNN WWWHHGGDIR QYNIEKKKNN VVRRNWLEMM PPGITTVVII SLDDDDRRRY YYYLLVNNNN WWWHHGGDIR QYNIEAAAKK VVSSGWLEMM PPAITTLLII SMDDDDRRRF FYYVVSCCCC WWWHHGGDIR QYDISLLLKK VVEENWLDMM PPAITTLLII SMDDDDRRRF FYYVVSCCCC WWWHHGGDIR QYDISKKKNN ---------- ---------- ---------- ---------- ---------- ---------- GGEENGIMMM GGGMTTLLII SLDDDDRRRY YYYFFSNNNN WWWHHGGDVR QYDISAAANN TTGGSGADMM GGGISSIIII SLDDDDRRRF FYYVVNCCCC WWWHHGGDVR QYDITEEENN ---------- ---------- ---------- ---------- ---------- ---------- VVAADINADD IIPPVVSSII AADDDDQQQT TWWIINSSSS FFFDDGGKTR LFDISHHHKK VVAADIEAKK VVPPVVSSII SNDDDDSSSR RWWVVNTTTT FFFDDGGKTR LFDISHHHHH PPVLLTTGGG KVIFFHRADH PP-------- ---HHHTGAM LSRDDGRRRR NNNLLYYTWD PPRLLAAGGG RVLYYHREPH PP-------- ---AAATGAM ISRDDGRRRR NNNLLYYSWN PPVLLAAGGG SVIAARRAPH PP-------- ---RRRAGGM VSRDDGRRRR NNNLLYYTWD PPKLLAAGGG SVIAARRTPH PP-------- ---KKKAAGM VSRDDGRRRR NNNLLYYTWD PPVLLTTGGG KVIVVKKTPH PP-------- ---KKKGYGM VSRDDGKRRR NNNLLYYTWD PPKLLTTGGG KVIVVSRATH PP-------- ---GGGNGGM VSRDDGRRRR NNNLLYYAVD PPRLLTTGGG KVIVVRRAGH PP-------- ---AAANGGM VSRDDGRRRR NNNLLYYAWD PPRHHTTGGG SVIVVRKAAH PP-------- ---GGGNGGM VSRDDGRRRR NNNLLYYSWD PPRLLTTGGG QISIIVRGGS VVLEEE-QQT TQPKKKPGGM ISLDDGKRRR TTTLLYYDWD PPRLLTTGGG QISIIVKGGS VVLEEE-QQT TQPKKKPGGM ISLDDGKRRR TTTLLYYAWD PPRLLTTGGG QLSIIVKGGP VVLEEE-QQK KQPKKKPGGM ISLDDGKRRR TTTLLYYAWD PPRLLTTGGG QLSIIVKDGP VVLDDD-QQD DQPKKKAGGM ISLDDGKRRR TTTLLYYAWD PPRLLTTGGG QLSIIVKGGP VVLEEE-QQK KQPKKKAGGM ISLDDGKRRR TTTLLYYAWD PPRLL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPRLLTTGGG QLSIIVKGGP VVLEEE-EEK KQPKKKAGGM ISLDDGKRRR TTTLLYYAWD PPRLLVVGGG QISIIVKGGP VVLEEE-QQK KQPKKKPGGM ISLDDGKRRR TTTLLYYDWD ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPKLLVVGGG QISIILRGGP VVLEEE-KKE EQPKKKPGGM ISLDDGKRRR NNNLLYYKWD PPKLLVVGGG QISIIQRGGP VVLEEE-KKE EQPKKKPGGM ISLDDGKRRR SSSLLYYIWD PPVLLTTGGG QLLIIQKGSP VVIGGG-DDT TQVQQQRGGM ITLDDGKRRR NNNLLFFAWD PPKLLTTGGG QVLIIQKGSP VVVKKK-DDT TQVKKKRGGM ISLDDGKRRR NNNLLFFAWD PPVLLTTGGG QILLLQKGSP VVVGGG-DDS SQVKKKRGGM ISLDDGKRRR NNNLLFFAWD PPVLLTTGGG QILLLQKGSP VVVGGG-DDT TQVKKKRGGM ISLDDGKRRR NNNLLFFAWV PPVLLAAGGG QVLLLQKGSE VVVTTT-DDE EQVHHHRGGM ISLDDGKRRR NNNLLFFRWD VVKLLNNSSS QVSVVHTESN VVLEEE-EE- -PARRREGGM LSLDDGKRRR TTTLLYYKWD PPKLLNNSSS QVSIIHSETT VVLEEE-DD- -EARRREGGM LSLDDGKRRR TTTLLYYKWD ---------- ---------- ---------- -------GGK ISVDDGKRRR NNNFFYYTWD PPRLLTTGGG QVAIIQRDAP RRLNNN-PPK KAPRRRLGGM LSLDDGRRRR SSSLLFFPWD PPKLLTTGGG QLAIICSDLP NNVKKKEKKK KRARRREGGM LSLDDGKRRR SSSLLYYPWD ---------- ---------- ---------- ---------- ---------- ---------- PPFQQIIYYY EKQVVN---- ---------- ---------M VSWDDGKRRR SSSLLLLNWD PPRQQVVYYY EKQVVN---- ---------- ---------M VSWDDGQRRR SSSLLLLNWD FYPEEGGGGG KWWMMLNNNA N------SSG IIKFDGE--- -AARRSHHHV SGSDCYYY-- FYP--GGGGG RWWMMVNNNV N------EEG LLKFDGR--- -AARRAHHHV WGTDCYYY-- FYPDDGGGGG PAAQQAHHHA G------DDG LLDYEPD--- -YYRRAHHHI EGTDCYYYSS FYPDDGGGGG PVVEEANNNV G------NNG LLKYSPD--- -YYRRAHHHI EGTDCYYYSS FYPGGDDDDD GAAMMANNNV G------NNG LLKFDPA--- -YYRRSHHHI EGTDCYYYSS FYPEEGGGGG DWWMMLDDDA G------NNG FFPFEPK--- -HHRRPHHHV QGSDCYYY-- FYPDDGGGGG KWWMMVDDDV N------DDG FFPFDGE--- -QQRRVHHHI QGSDCFFF-- FYPVVGGGGG RWWIIAEEEA D------GGG LLPFEGD--- -LLRRPHHHI EGSDCYYYSS FY-PPDDDDD IEEGGMLLLQ VDVVVTTNNG LLPFDGKPLG PAALLAHHHL PGSDI----- FY-PPNNNNN IEEGGMLLLQ IDVVVTTNNG LLPFDGKPLG PAALLAHHHL PGSDI----- FY-PPDDDDD IEEGGMLLLQ IDVVVTTKKG LLPFDGKPLG PAALLAHHHL PGSDL----- FY-PPDDDDD IEEGGMLLLQ IDVVVTTKKG LLPFDGKPLG PAALLAHHHL PGSDL----- FY-PPDDDDD IEEGGMLLLQ VDVVVTTKKG LLPFDGKPLG PAALLAHHHL PGSDI----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FY-PPDDDDD IEEGGMLLLQ VDVVVTTKKG LLPFDGKPLG PAALLAHHHL PGSDI----- FY-PPDDDDD IEEGGMLLLQ IDVVVTTKKG LLPFDGKPLG PAALLAHHHI PGSDL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FY-PPDDDDD IEEGGMLLLQ IDVVVTTKKG LLPFDGKPGG PVVLLAHHHL PGSDV----- FY-PPDDDDD LEEGGMLLLQ IDVVVTTKKG LLPFDGKPDG PVVLLAHHHI PGSDI----- FY-PPGGGGG VKKGGILLLQ IDVVVTTKKG IIPFDGAPDG PAALLAHHHM PGSDI----- FY-PPKKKKK VQQGGILLLQ IDVVVTTNNG IIPFDGAPDG PSSLLAHHHM PGSDI----- FY-PPEEEEE MKKGGIIIIQ IDVVVTTKKG IIPFDGDPEG PAALLAHHHM PGSDI----- FY-PPEEEEE MKKGGIIIIQ IDGGGTTKKG IIPFDGDPDG PSSLLAHHHM PGSDI----- FYGQQDDDDD VKKGGMLLLQ IDVVVTTKKG IIPFDGAPEG PSSLLAHHHM PGSDI----- FY-PPEEEEE VSSGGMVVVQ VNIIIPPSSG IIRFDGKEGG PYYLLAHHHM PGSDI----- FY-PPEEEEE VSSGGMLLLQ IDVVVPPTTG IIKFDGKPGG PYYLLAHHHM PGSDI----- FY-PPNNNNN VEEGGMLLLQ IDVVVTTKKG VVKFDGKPNG PCCLLAHHHI PGSDA----- FY-PPEEEEE VAAGGIVVVQ LDIIIVVNNG LLEFDGGPYG PGGLLPHHHM ---------- FY-PPKKKKK VQQGGIVVVL IDVVVTTNNG LLEFDANPYG PSSLLPHHHM PGSDLAAADD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -KKGGDAAAQ YLKKKYYWWD LLEFDYEGLG ---RRAHHHM GSSS------ ---------- -KKGGDEEEQ FLKKKYYWWD LLEFDYAKLG ---RRPHHHM GRAGGDDDNN ------- ------- SVV---- SVV---- SVV---- ------- ------- S------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- DAA---- ------- ------- NRRAREE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158KKKKKQPSSS EATCCCAVLT AAAADDGAQL QLLSLLTGSS SSSVKKKKAY YQQQAAWWFF gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------M MAAARRAATT gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMT ---------- ---------- ---------- ---------- ---------- ---------- FSAAQQQLLA SSSSPPESKK GGRTSPGVEA AVVPPSAWWA HLPKHGAAIA GLLLGAAHHT ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------MMT ---------- ---------- ---------- ---------- --EAEGAFQA PMRRISSTTT ---------- ---------- ---------- ---------- ---------- -------MMT ---------- ---------- ---------- ---------- ---------- -------MMT ---------- ---------- ---------- ---------- MLKEPGHTPL GQLLQDDTTT ---------- ---------- ---------- -------LLL KSGLGFDQTH YCTTVTTSST ---------- ---------- ---------- ---------- ---------- -------MMT TPPPNNNRRT PPPTPPNPLL AAPSPPRPLV VTTNNVRCCP PAHLVLQHEA VETTAAANNK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------A ---------- ---------- ---------- ---------- --------AL HGVVNKKKK- ---------- ---------- ---------- ---------- --------GL HAVVSKKVVN ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --MMAAANNA ---------- ---------- ---------- ---------- ---------- ----SNNCCL ---------- ---------- ---------- ---------- ---------- ----P--CCL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -MREFG---- ALAAGAALLM ---------- ---------- ---------- ---------- -MRIVSGPHL ALVVGAALLL AIVPKRRRTP PPPPPMMMAA AAKKEELAAA YVCCCTGTTG IINRAAAFVV VVVVSYSSSK -MAKKPPPTP PPPPPDDDAA AARREEIAAA YVAAAVGTTG VVNAPPPFVV VVVVSYGGGK --MSRPPPTA APPPPLLLAA AAQQEEFAAA YTLLLPDFFS ---RPPPAVV VIIVSYGGGK --MTRPPPTA APPPPLLLAA AAEEEEFAAA YTLLLPDFFS ---KPPPAVV VIIVSYGGGQ --MTRPPPTP PAAAALLLAA AAEEEELAAA FTMMMPDAAS ---KPPPGVV VVVVSFGGGQ -MATKPPPSP PPPPPLLLAA AAKKEEIAAA YVMMMPERRK ---QPPPAVV VVVVSYAAAS -MVTRPPPTP PPPPPMMMAA AAKKEELAAA YVRRRPMAAN GG-KPPPAVV VVVVSFGGGQ -MASRPPPTP PPPPPMMMAA AAQQEELGGG YVLLLPGRRE ---RPPPAVV VLLLSYAAAQ KCTK-CCCGT TLLLLAAAMM MM--EEIVVV YLCCCRNTTG TTEAPPPYTT TVVVSYSSSQ ---------- ---------- ----EEIVVV YLCCCRNTTG IIEAPPPYTT TVVVSYSSSQ QCGK-CCCGS SLLLLAAAMM MM--EEIVVV YLCCCGNTTG IIEAPPPYTT TVVISYCCCQ ---------- --------MM MM--EEIIII YLCCCRNTTG IIEAPPPYTT TVVVSYCCCQ KCGN-CCCGT TLLLLAAAMM MM--EEIVVV YLCCCRNTTG TTEAPPPYTT TVVVSYCCCQ KCGN-CCCGT TLLLLAAAMM MM--EEIVVV YLCCCRNTTG TTEAPPPYTT TVVVSYCCCQ KCGN-CCCGT TLLLLAAAMM MM-------- ---------- TTEAPPPYTT TVVVSYCCCQ KCGN-CCCGT TLLLLAAAMM MM--EEIVVV YLCCCRNTTG TTEAPPPYTT TVVVSYCCCQ KCGD-CCCGT TQQQQAAAMM MM--EEIVVV YLCCCRNTTG TTEAPPPYTT TVVVSYSSSQ KCGN-CCCGT TLLLLAAAMM MM--EEIVVV YLCCCRNTTG TTEAPPPYTT TVVVSYCCCQ KCGN-CCCGT TLLLLAAAMM MM--EEIVVV YLCCCRNTTG TTEAPPPYTT TVVVSYCCCQ TCCHAKKKGT TLLLLAAAMM MMKKEELVVV YVCCCNGTTG IINKLLLYTT TVVLSYSSSQ ---------- ---------- ---------- ---------- ---------- ---------- KCGS-CCCGS SLLLLAAAMM MM--EEIVVV YLCCCRSTTG IINKPPPYTT TVVVSYSSSQ VNGCKSSSGS SIIIISSSMM MM--EELIII YVAAAAGTTG IIEKPPPYTT TVVVSYSSSK QQGCKSSSGS SLLLLAAAMM MM--EELIII YVAAAAGTTG IIEKPPPYTT TVVLSYSSSK ---------- ---------- ---------- ---------- ---------- ---------- -RMLVGGGGT TLLLLAAAMM MM--EELIII YVAAATGTTG IIDKPPPYTT TVVVSYSSSS ACCGATTTGT TLLLLAAAMM MMKKEELLLL YVCCCNGTTG IINKPPPYTT TVVVSYSSSQ KCHG----GS SAAAAAAAII II--EEVLLL FVAAA--NNA AADGPPPATT TVVVSFCCCQ KCHG----GS SAAAAAAAII II--EEVLLL FVAAA--HHA RRDGPPPATT TVVVSFCCCQ ---------- ---------- ---------- ---------- ---------- ---------- SESKKCCCGT TLLLLAAAVV VVNNEELLLL YVCCCPNLLD EEEHGGGYTT TVVVSYCCCQ ---------- --------MM MMSSEELLLL YTTTTPNLLD EEPHGGGYTT TVVVSYCCCQ --------GT T----IIILL LLSSRRLYYY FSWWWGDIIR QQYDIIIDNN NPPMVGGGGS GLPFAFFFEQ QPPPPMMMPP PPIIEEFVVV YVTTTVEGGM GGDEQQQKTT TIILSRGGGQ AAPAVRRREA APPPPMMMKK KKIIEEYVVV YVTTTAEGGV GGDEQQQKTT TVVASYGGGK KKKKIIVHHL PPYINDLLHH HHHFGGCCSA ALCCG-KKKP NERRRLIVVP PGRRRSDTKK KKKKVVIYYL PPYIGDLLHH HHHFGGCCSA AYCCA-KKKP FERRRLIVVP PARRRSDTKK KKKKIIVHHM PPNTGDFFHH HHHFGGCCSS SLSSTGHHHA FERRRLIIIP PGRRRSDTKK QQQQIIVHHM PPNKGDFFHH HHHFGGCCSA ALSSAGHHHA FERRRLIIIP PGRRRSDTKK QQQQIIVHHM PPNKGDFFHH HHHFGGCCSA ALSSTGHHHA FERRRLIIIP PGRRRSDVKK SSSSIIVGGM PPHAGDLLHH HHHFGGCCSC CLCCAPHHHP HERRRLVVVP PGRRRSDTKK QQQQVVVGGM PPYTGGLLHH HHHFGGCCSM MLCCAPHHHP HERRRLVVVP PDRRRSDTKK QQQQIIVGGM PPNAADLLHH HHHFGGCCSA ALCCAPHHHP HERRRLIVVP PGRRRSDTKK QQQQVVIHHM PPYLKDLLHH HHHSGGCCSC C---FGDDDS TSRNNLILLP PGMMMSDVGG QQQQVVIHHM PPHLKDLLHH HHHSGGCCSC C---FGDDDS TSRDDLILLP PSIIISDVGG QQQQVVIHHM PPNLRDLLHH HHHSGGCCSC C---FGDDDS TSRTTLMLLP PCMMMSDVGG QQQQVVIHHM PPHLKDLLHH HHHSGGCCSC C---YGDDDI TARTTLVLLP PAIIISDVGG QQQQVVIHHM PPNLKDLLHH HHHSGGCCSC C---FGDDDS TSRTTLVLLP PSIIISDVGG QQQQVVIEE- ---------- ---------- ---------- ---------- ---------- QQQQVVIHHM PPNLKDLLHH HHHSGGCCSC C---FGDDDS TSRTTLVLLP PSIIISDVGG QQQQVVIHHM PPNLKDLLHH HHHSGGCCSC C---FGDDDS TSRTTLVLLP PSIIISDVGG QQQQVVIHHM PPYLKDLLHH HHHSGGCCSC C---FGDDDS TSRNNLVLLP PSIIISDVGG QQQQVVIHHM PPNLKDLLHH HHHSGGCCSC C---FGDDDS TSRTTLVLLP PS-------- QQQQVVIHHM PPNLKDLLHH HHHSGGCCSC C---FGDDDS TSRTTLVLLP PSIIISDVGG QQQQVVIHHV IIHIGDLLHH HHHSGGCCSC C---HGDDDP SKRRRLILLP PSLLLGDTAA ---------M PPNTNDLLHH HHHSGGCCSC C---YGDDDA SVRNNLILLP PCIIISDVGG QQQQVVIHHM PPNVNDLLHH HHHSGGCCSC C---YGDDDS SVRNNLILLP PCIIISDVGG KKKKVVIHHV PPYVGDLLHH HHHTGGCCSC C---HGDDDP SERRRLIAAP PSVVVGDTKK KKKKVVIHHV PPYVGDLLHH HHHTGGCCSC C---HGDDDP SQRRRLIVVP PGVVVGDTKK ---------M PPFVGDLLHH HHHSGGCCSC C---HGDDDA SDRRRLVLLP PSIIIGDTKK SSSSVVIHHM PPFVGDLLHH HHHSGGCCSC C---HGDDDA SDRRRLVLLP PSIIIGDTKK QQQQVVIHHV TTHVGDLLHH HHHSGGCCSC C---HGDDDP SSRRRLILLP PSLLLGDTLL QQQQVVISSV PPHIGDVVHH HHHTGGCCSC C---HDKKKP TKRSSLIVVP PCNNNDNVEE QQQQIIISSV PPNIGDVVHH HHHTGGCCSC C---HDKKKP TKRSSLIVVP PCNNNDNVEE ---------- ---------- ---------- ---------- -----MVPPR RKSSSGFVGG QQQQVVIHHT NNSKHNLLHH HHHSGGCCSC CHFFGGKKKE VTRDDLVLLP PCNNNDDTGG QQQQIIVHHT NNRKGDLLHH HHHSGGCCSC CYYYSSKKKT VKRDDLVLLP PSNNNDDVVV SSSSVVLKKV KKVLEDEELL LLLSQQRRIK K----GKKKR VGGPPMLQQL LSDDDKTSLL QQQQVVINNV GGG-RNAAHH HHHGGG---- ---------- -DRRRFWTTG GGDDDNDVHH KKKKVVVNNV GGG-RNAAHH HHHSDD---- ---------- -DRRRLWAAG GGDDDSDVHH NPEEPIIKKK VIPEEVVKKV VGYSRLHTVV CCCGPPPDDA IIAALGNE-E G-GGGGILDH DKRRPVVKKK IVPEVAAVVR RGYTKYHTVV CCCGPPPDDA IIAALGGP-D GRGGGGIFDH HPQQAIIKKK IIPDEIILLK KGYSRPHTVV CCCGPPPEEG VVTTLGGAGD GTGPPGIFDC DPKKAIIKKK IIPEEVVFFK KGYSRPHTII CCCGPPPDDG VVTTLGGGGD GTGPPGVFDC EPKKAIIKKK IIPEEVVFFK KGYSRPHTII CCCGPPPEEG VVTTLGGGGD GTGPPGIFDC DPKKPLLKKK VIPETLLAAR RGYSRPHTVV CCCGPPPGGG VVAALGNA-E G-GGGGIADA DPQQPVVKKK VIPNELLAAR RGYARPHTVV CCCGPPPDDG IIAALGSP-E G-GGGGIFDH DPEEPIIKKK VIPEELLHHR RGYSRPHTII CCCGPPPDDG VVAALGSP-E G-GGGGVFDH EPAAPLLKKK VIASEIIQQK KNVSNTHTSS CCCLAAASSG MMNNTLGD-L QGGGGSFVDG EPAAPLLKKK VIPNEIIHHK KNLGNLHTSS CCCLAAASSG MMSSSLGD-P QGGGGGFVDG DPAAPLLKKK VIAEDIIHHK KGLGYVHTSS CCCLAAASSG MMSSTLGD-S KGGGGGFVDG EPAAPLLKKK VIPKDIIHHK KNLGFFHTSS CCCLPPPSSG MMSSTLGD-P EGGGGGFVDG EPAAPLLKKK VIPEDIIHHK KELAFLHTSS CCCLAAASSG MMSSSLGD-V KGGGGGFVDG ---------- --PKDIIHHK KELAFLHTSS CCCLAAASSG MMSSSLGD-V KGGGGGFVDG EPAAPLLKKK VIPKDIIHHK KELAFLHTSS CCCLAAASSG MMSSSLGD-V KGGGGGFVDG EPAAPLLKKK VIPKDIIHHK KELAFLHTSS CCCLAAASSG MMSSSLGD-V KGGGGGFVDG EPAAPLLKKK VIAKDIIHHK KGLGTPHTSS CCCLPPPTTG MMSSTLGD-P KGGGGGFVDG ---------- ---------- ---------- ---------- ---------- ---------- EPAAPLLKKK VIPKDIIHHK KELAFLHTSS CCCLAAASSG MMSSSLGD-V KGGDDGSLLP DPTTPLLKKK VVSEDIIAAN NGLGFPHTSS CCCLAAASSG MMSSCLGD-K EGAGGNGFLD DPAAPIIKKK TVPYEVVFFK KGLANLHTSS CCCLGGGCCG MMSSSIGD-P YGGGGGFVDG DPAAPIIKKK TVPYEVVFFK KGLANPHTSS CCCLGGGCCG MMSSSLGD-P CGGGGGFVDG NPSSPLLKKK VVPADIIIIK KGLAYPHTSS CCCLAAASSG MMSSCLGD-K DGAGGNGFLD NPAAPLLKKK VVPEDIISSK KGLAYPHTSS CCCLAAASSG MMSSCIGD-K DGAGGNGFLD NPAAPLLKKK YVPKEIIAAK KGLAYPHTAA CCCLAAASSG LLSSCLGD-E EGAGGNGFLD NPAAPLLKKK YVPKEIIAAK KGLAFPHTAA CCCRTTT--G LLSSCLGD-E EGAGGNGLLD DPAAPLLKKK VVAEDIIAAK KGLGFPHTSS CCCLAAASSG MMSSCLGD-K EGAGGNGFLD E-KKILLHHH TIPSKLLHHL L-LSFPHTSS CCCLAAADDG MMSSTLGE-A NGPGGNFLDG E-EEILLHHH TIPSKLLHHL L-LSFPHTSS CCCLAAADDG MMSSTLGE-A DGPGGNFLDG ---------- ---------- ---------- ---------- ---------- ---------- DPAAPLLKKK VIG-DVVLLG GDCTAPHTTT CCCLPPPNNG MMSSIMGD-A EGAGG-DFFD DPKKPIIKKK TIG-DVVLLS SNVTAPHTTT CCCLAAANNG MMSSVMGD-A EGAGG-DFFD SADDKFFPPP ----DLLIIF FVLAISHTAA YYYQPPPNNT KKDDGVNE-S LSPLLNGISK DPNNPLLKKK TIT-FVVKKS SGVVGPHTFF AAALPPPGGS IIGGLSND-D DHGTTALVND DPRRPLLKKK TID-FVVEES SGVVGPHTLL AAALPPPGGR IIGGLSNN-K DHGTTALVTN HYYLGWIDRR GDQQQYY--- ---------- -----LAYYD DWN-PPPEEL LSEAVVVPPN HDDIGWVYRR GPQQQYY--- ---------- -----FAYYD DWN-PPPGGM MSETVVVPPR CEELGWIDRR GPQQQDD--- ---------- -----KHYYD DWN-PPPDDM MSEALLLPPP CEELGWIDRR GPQQQTT--- ---------- -----LHYYD DWN-PPPDDM MSEALLLPPP CEELGYMDRR GEQQQTT--- ---------- -----KHYYD DWN-PPPDDM MSEGLLLPPP AQQLGWVERR GPQQQYY--- ---------- -----FAYYD DWH-GGGDDL LSEGTTTPPD HDDLGWIDRR GDQQQYY--- ---------- -----LHYYD DWH-GGGDDL LSEGTTTPPR HEELGWVERR GPQQQQQ--- ---------- -----LAYYD DWH-GGGDDM MSEGTTTPPN GEEKGWKPGG GASSSPP--- ---------- -----MGYYD DYQ-RRRNNM MTEAAAAPPN GEEKGWKPGG GEAAAPP--- ---------- -----MGYYD DYQ-RRRNNM MTEAAAAPPN GEEKGWQPGG GAAAAPP--- ---------- -----MGYYD DYQ-RRRNNM MTEAAAAPPN GKKKGWQPGG GAAAAPP--- ---------- -----LGYYD DYQ-RRRNNM MTEAAAAPPN GEEKGWRPGG GAAAAPP--- ---------- -----SGYYD DYQ-RRRNNM MTEAAAAPPN GEEKGWRPGG GAAAAPP--- ---------- -----LGYYD DYQ-RRRNNM MTEAAAAPPN GEEKGWRPGG GAAAAPP--- ---------- -----LGYYD DYQ-RRRNNM MTEAAAAPPN GEEKGWRPGG GAAAAPP--- ---------- -----LGYYD DYQ-RRRNNM MTEAAAAPPN GEEKGWRPGG GSAAAPP--- ---------- -----MGYYD DYQ-RRRNNM MTEAAAAPPN ---------- ---------- ---------- ---------- ---------- ---------- P--SG----- ---------- ---------- ---------- ---------- -AIAHHHSSN DSSKGGNRLL FPIIISS--- ---------- -----KERRT TYEYAAAGGF FWICCCCSSL GEEKGWAEGG EAAAAPP--- ---------- -----FGYYD DYQ-RRRNNM MTEGAAAPPK GEEKGWVEGG ESAAAQQ--- ---------- -----FGYYD DYQ-RRRNNM MTEGAAAPPK DSSKGWKPGG HSPPPLL--- ---------- -----FGYYD DYQ-RRRNNM MTSGAAAPPT DSSKGWKPGG HSPPPLL--- ---------- -----FGYYD DYQ-RRRNNM MTSGAAAPPK DSSKNWKPGG HSPPPLL--- ---------- -----FGYYD DYQ-RRRKKM MTSGAAAPPK DSSKNWKPDD ISPPPLL--- ---------- -----YGYYH HYQ-RRRKKM MTSGAAAPPK DSSKGWKPGG HSPPPLL--- ---------- -----FGYYD DYQ-RRRKKM MSSGAAAPPA GKKKGWADEE KTVVVPP--- ---------- -----FNYYD DYQ-RRRNNM MTEGSSSPPN GKKKGWADGG KVVVVPP--- ---------- -----FNYYD DYQ-RRRNNM MTEGSSSPPN ---------- ---------- ---------- ---------- ---------- -ILGGGGPPV DKKVGWRGDD RKAAALL--- ---------- -----CGYYD DYQ-HHHNNM MSEGAAAPPK DSSIGWKGDD KKAAALL--- ---------- -----CGYYD DYQ-YYYDDM MSEGAAAPPN KHHSAGASQQ FEEEEII--- ---------- -----LQLLS SNN----EES SDRDEEEPPI DDDATWPTAA DDMMMQQGAA AVVAAGGDAA VVAAGYGYYD DAL-RRRNNM MSSTGGGWWS NAAATWPTDD GDLLLRRGAA AIIKKGG-KK YYAAGYDYYD DAL-RRRNNL LSSTGGGWWN ----TEDGGK KLEHKKKDD- -NIHFDLRKI HHHLTGGEMM ML----ELRP PLLTKLLMGF ----CEEGGS SLECKKKEEG GNLHVDLRRL YYYIDGGQMM ML----EVRP PLLTKLLMGF ----QENGGV VPEDLLLAAN NHLHFDLRRV QQQIDGGAMM ML----EVRP PAAVREEYGF ----QENGGV VPEDLLLSSN NHLHFDLRRV QQQIDGGAMM ML----EVRP PAAVREEYGF ----QENGGV VPEDLLLSSN NHIHFKLRKV QQQIDGGAMM ML----EIRP PAASKDDYGF ----MEDGGV VPDILLLGGA ARLHFDLRRL QQQIDGGDLL LF----ELRP PAATKAAYGF ----MESGGL LGDELLLAAG GHLHVDLRRL QQQLDGGAMM ML----ELRP PAATKAAYGF ----MEGGGD DPQILLLNNK KRLHIDLRRL QQQLDGGEMM ML----ELRP PAAARTTYGF ----VKDGGP PAHVAAA--G GSIFVDWHEI QQQLQTT-LL LP--LLEIRF FLLSATTQGF ----VKDGGP PAHVAAA--G GSIHVDWHEI QQQLQKK-LL LP--LLEIRF FLLDATTQGF ----VRDGGP PADVAAA--G GSLHVDWHEI QQQLTQQ-LL LP--LLEIRF FLLDAAAQGF ----VRDGGP PADVAAA--G GSLYVDWREV QQQLPQQ-LL LP--LLEIRF FLLDAAAQGF ----VRDGGP PADVAAA--G GSLYVDWHEV QQQLSKK-LL LP--LLEIRF FLLDAAAQGF ----VRDGGP PADVAAA--G GSLYVDWHEV QQQLSKK-LL LP--LLEIRF FLLDAAAQGF ----VRDGGP PADVAAA--G GSLYVDWHEV QQQLSKK-LL LP--LLEIRF FLLDAAAQGF ----VRDGGP PADVAAA--G GSLYVDWHEV QQQLSKK-LL LP--LLEIRF FLLDAAAQGF ----VQNGGP PADVAAA--G GKLHVDWHEV QQQLLPP-HH HP--LLEIRF FLLAASSQGF ---------- ---------- ---------- ---------- ---------- ---------- ----LLTGGD DYPAAAA--S SGT------- ---------- ---------- ---------- ----FTTGGL LMCLAAA--S SVSCLNYRVD EEELPQQ-AA AANILLCLRS SIININNQDY ----AALGGM MEEVAAA--G GHLNVDWHRI QQQIDGGELL LP--LLEIRF FLLDAAAQGL ----AALGGM MEDVAAA--G GHLNVDWHRV QQQIDGGKLL LP--LLEIRF FLLDADDQGL ----ATKGGL LQHVDDD--G GRLTCQLGER QQQLDGGNLL LP--LLEIRF FLLAKDDTGF ----ALQGGL LQHVDDD--G GRLHVSWGEK QQQLDGGDLL LP--LLEIRF FLLAKDDTGF ----ASKGGL LQHVDDD--G GSLHVSWGEK QQQIDGGELL LP--LLEIRF FLLSKDDTGY ----ASKGGL LQHVDDD--G GSLHVSWGEK QQQIDGGPLL LP--LLEIRF FLLSKDDTGF ----ARTGGL LQHVDDD--G GRLHVDWGEK QQQLDGGSLL LP--LLEVRF FLLSKDDTGY ----HKKGGP PAHVEEE--G GNVHIEWKKL QQQIDPPQAA AP--LLEVRF FLLTSEEHAF ----HKKGGP PAHVEEE--G GNVHIEWKKL QQQIDPPMAA AP--LLEVRF FLLTSEEHAF ----TCRDDL LKCQEEE--P PKKRV----- ---------- ---------- ---------- ----LRRGGP PTDCDDDRRT TCLNFRWREF QQQIDGGDLL LP--LLEIRF FLLRENNQGY ----KRRGGN NVDLDDDMMS SCLNFKWQTY QQQIDGGSII IP--LLEIRF FLLKKAAEGF ----MFESSS SFLKTTTGGP PQVAEL---- ---------- ---------- ---------- NNYYMDFGGL LQDAAAAMMK KNIVQDLRQK KKKFNPPG-- ----LLEIRF FPPNANNYAF NNYYMDFGGL LADPAAAMMK KNVVTDLKQK KKKFDPPG-- ----LLEIRC CAAAHNNYCF IVVVSLLKDL LSSSSILWWY -EGGGWNNEE EVIIIPPPPP PLE-NNLPPE ILLLPPVPPV VVLLNTTKDL LSSSSILWWY -EGGGWQQEE EVIIIEEEPP PFE-PPLPPP VLLLDDVPPV VVVVDTTTNL LGSSSITWWR -EGGGFHHKK KTIIIPPPPP PATDEELPPP LLLLGGVPPV VVVVDTTTNL LASSSITWWR -EGGGFHHEE ETIIIPPPPP PAPEKKLPPP LLLLGGVPPV CVVVDTTTNL LGAAAITWWQ KDGGGFEEKK KTIIIDDDPP PADDDDLPPD LLLLGGCPPV VVIISLLKDL LSSSSITWWR -DDDDWAARR RVIIIPPPAA AADDQQLPPP VLLLGGVPPV MVVVSLLKDL LASSSILWWR -DGGGWHHKK KVIIIPPPPP PASDQQLPPP ILLLPPVPPV VVVVSLLEDL LASSSVLWWR -QGGGWGGRR RVIIIPPPPP PAEDQQLPPP LLLLDDVPPV VALLSSSNIQ QFYYYKEEE- ---------- --SSSVVVVV VIQPSSKKKV KGGGMMMGGI VALLSSSNIQ QFYYYKEGG- ---------- --SSSVVVVV VIQPSSKKKV KGGGMMMGGI VALLSSSTIQ QFYYYKQGG- ---------- --SSSVVVVV VIQPPPKKKV KGGGMMMGGI VALLSSSTIQ QFFFFKEDD- ---------- --SSSAAAVV VIQPPPKKKV KGGGMMMGGI VALLSSSTIQ QFYYYKEGG- ---------- --SSSVVVVV VIQPPPKKKV KGGGLLMGGI VALLSSSTIQ QFYYYKEGG- ---------- --SSSVVVVV VIQPPPKKKV KGGGLLMGGI VALLSSSTIQ QFYYYKEGG- ---------- --SSSVVVVV VIQPPPKKKV KGGGLLMGGI VALLSSSTIQ QFYYYKEGG- ---------- --SSSVVVVV VIQPPPKKKV KGGGLLMGGI VALLSSSTIQ QFYYYKEGG- ---------- --SSSVVVVV VIEPPPKKKV KGGGMMMGGI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DEVVSFFSGR RGSSSDDAA- ---------- --VVVLLLKK KLDYYYAVVV AKKKGGLNNF VALLSSSTVF FFYYYKKDD- ---------- --AAAAAAVV VIKPSSKKKV EGGGAAMGGI VALLSSSSIF FFYYYKKDD- ---------- --AAAAAAVV VIQPSSKKKV EGGGPPMGGI VALLSSSNMI IFFFFKQDD- ---------- --SSSHHHAA AIPKPPLKKV QNNNIIMGGI VALLTSSNMI IFFFFKQDD- ---------- --NNNHHHVV VISEPPLKKV QNNNFFMGGI VALLSSSNMI IFFFFKSDD- ---------- --SSSYYYVV VISKPPLKKV ENNNIIMGGI VALLSSSNMI IFFFFKSDD- ---------- --SSSHHHVV VISKPPLKKV ENNNIIMGGI VALLTSSNMV VFFFFKADD- ---------- --SSSHHHAA AISKPPLKKV RNNNIIMGGI VALLGSSGIF FIHHHPEEES ---------- --AAAAAAVV VAFPSSKKKV SGGGAAMAAI VALLGSSAIF FIHHHPEKKP ---------- --TTTAAAVV VATPSSKKKV ENNNAAMAAI ---------- ---------- ---------- ---------- ---------- ---------- VAFFXXXXXX XXXXX----- ---------- ---------- -------QQG ENNNEEMGGM VALLNAAKVF FFKKKKSDDD ---------- -FKKKKKKDD DIPKLLVDDT GSSSVVMGGI ---------- ---------- ---------- ---------- ---------- ---------- SALLTSSQLW WIYYYEDAA- ---------- ---------- --EQAAKAAV ADDDGGDPPP TALLTSSQLW WIYYYEGEE- ---------- ---------- --EQAAKAAV ADDDGGKPPP TTTIIIIIIS LDDLLLWWII GEVVQDDISS FKKPPPVLLL LTKKLGFRRA HHP------- TTTIIIIIIS LDDLVLWWLL GELLQDDITT HQQPPPRLLL LARKIGYRRE HHP------- TTTIIIIILS LDDLVCWWTT GEMMQDDVSS HNNPPPVLLL LASRIGARRA HHP------- TTTIIIIILS MDDLVCWWTT GEMMQDDVSS RKKPPPKLLL LASHIGARRT HHP------- TTTIIIIILS LDDLVCWWLL GEMMQDDVSS MNNPPPVLLL LTKEIGVKKT HHP------- TTTIIIIILS MDDLVCWWTT GDLLQDDVSS FEEPPPKLLL LTKRIGVRRA HHPG------ TTTIIIIILS VDDLVCWWTT GELLQDDVSS FNNPPPRLLL LTKQIGVRRA HHP------- TTTIIIIILS LDDLVCWWTT GELLQDDVSS FNNPPPRHHH HTSRLGVKKA HHP------- TTTIIIIILS LDDLFNWWHH GDIIQDDISS QKKPPPRLLL LTQFLGIRRG SSVQVE-QTT TTTIIIIILS LDDLFNWWHH GDIIQDDISS KKKPPPRLLL LTQFLGIKKG SSVQVE-QTT TTTIIIIILS LDDLFNWWHH GDLLQDDISS QRRPPPRLLL LTQFLGIKKG PPVQVE-QKK TTTIIIIILS LDDLFNWWHH GDIIQDDVSS QRRPPPRLLL LTQFLGIKKD PPVQVD-QDD TTTIIIIILS LDDLFNWWHH GDLLQDDISS QRRPPPRLLL LTQFLGIKKG PPVQVE-QKK TTTIIIIILS LDDLFNWWHH GDLLQDDISS QRRPPPRLLL L--------- ---------- TTT------- ---------- ---------- ---------- ---------- ---------- TTTIIIIILS LDDLFNWWHH GDLLQDDISS QRRPPPRLLL LTQFLGIKKG PPVQVE-EKK TTTIIIIILS LDDLFNWWHH GDMMQDDISS KRRPPPRLLL LVQFLGIKKG PPVQVE-QKK ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPPAAAAAIF FDDIFS---- ---------- ---------- ---------- ---------- TTTIIIIIIS LDDLFNWWHH GDIIQDDITT RNNPPPKLLL LVQFLGIRRG PPVTVE-KEE TTTIIIIIIS LDDLFNWWHH GDIIQDDITT RNNPPPKLLL LVQFLGIRRG PPVTVE-KEE TTTFFFFFIS LDDLFNWWHH GDIIQNNIEE KNNPPPVLLL LTQWVGIKKG PPVAAG-DTT TTTFFFFFIS LDDLFNWWHH GDIIQNNIEE KNNPPPKLLL LTQWAGIKKG PPVVAK-DTT TTTFFFFFIS LDDLFNWWHH GDIIQNNIEE KNNPPPVLLL LTQWVGLKKG PPVKAG-DSS TTTFFFFFIS LDDIFNWWHH GDIIQNNIEE KNNPPPVLLL LTQWVGLKKG PPVKAG-DTT TTTFFFFFIS LDDLLNWWHH GDIIQNNIEE AKKPPPVLLL LAQWAGLKKG EEVVYT-DEE TTTIIIIIIS MDDLVCWWHH GDIIQDDISS LKKVVVKLLL LNQYIGVTTE NNVKVE-E-- TTTIIIIIIS MDDLVCWWHH GDIIQDDISS KNNPPPKLLL LNQFIGISSE TTVKVE-D-- ---------- ---------- ---------- ---------- ---------- ---------- TTTIIIIIIS LDDLFNWWHH GDVVQDDISS ANNPPPRLLL LTQFLGIRRD PPRRVN-PKK SSSIIIIIIS LDDLVCWWHH GDVVQDDITT ENNPPPKLLL LTQFLGISSD PPNVIKEKKK ---------- ---------- ---------- ---------- ---------- ---------- VVVIIIIIIA ADDLISFFDD GKTTLDDISS HKKPPPFQQQ QIEVIDV--- ---------- VVVIIIIIIS NDDLVTFFDD GKTTLDDISS HHHPPPRQQQ QVETIGV--- ---------- -------AHH KLTTTTGAPP MMLESRDDGR VVVYTTNNSL YWWWQFPEGG LLKWVVKLLL -------SAA EATTTTGAPP MMISSRDDGR VVVYTTNNSL YWWWQFP-GG LLRWAAKVVV -------NRR TFAAAAGGPP MMVESRDDGR VVVYTTNNSL YWWWQFPDGG VVPAVVLAAA -------NKK AFAAAAAGPP MMVESRDDGR VVVYTTNNSL YWWWQFPDGG VVPVVVMAAA -------NKK TFGGGGYGPP MMVESRDDGR VVVYTTNNSL YWWWQFPGDD RRGAVVMAAA -----AAKGG ALNNNNGGPP MMVESRDDGR VVVYTTNNSL YVVVQFPEGG IIDWVVKLLL -----AATAA ELNNNNGGPP MMVESRDDGR VVVYTTNNSL YWWWQFPDGG IIKWVVKVVV -------AGG PLNNNNGGPP MMVESRDDGR VVVYSSNNSL YWWWQFPVGG IIRWAAKAAA CCCPVVVKKK RIPPPPGGPP MMIQSLDDGR LLLYTTTTSL YWWWQF-PDD LLIESSVMMM CCCPVVVKKK RVPPPPGGPP MMIQSLDDGR LLLYTTTTSL YWWWQF-PNN LLIESSVMMM SSSPVVVKKK KVPPPPGGPP MMIQSLDDGR LLLYTTTTSL YWWWQF-PDD LLIESSVMMM SSSPVVVKKK QVAAAAGGPP MMIQSLDDGR LLLYTTTTSL YWWWQF-PDD LLIESSVMMM SSSPVVVKKK RVAAAAGGPP MMIQSLDDGR LLLYTTTTSL YWWWQF-PDD LLIESSVMMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- SSSPVVVKKK RVAAAAGGPP MMIQSLDDGR LLLYTTTTSL YWWWQF-PDD LLIESSVMMM SSSPVVVKKK RVPPPPGGPP MMIQSLDDGR IIIYTTTTSL YWWWQF-PDD LLIESSVMMM ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- CCCPIVVKKK KVPPPPGGPP MMIQSLDDGR LLLYTTNNSL YWWWQF-PDD MMIESSVMMM CCCPTVVKKK IIPPPPGGPP MMIQSLDDGR IIIYTTSSSL YWWWQF-PDD LLLEAAVMMM WWWVEIIQQQ KLRRRRGGPP MMIQTLDDGR LLLYTTNNSL FWWWQF-PGG LLVKSSHIII WWWVEIIQKK KLRRRRGGPP MMIQSLDDGR LLLYTTNNSL FWWWQF-PKK LLVQSSHIII FFFVQIIKKK SLRRRRGGPP MMIQSLDDGR LLLYTTNNSL FWWWQF-PEE LLMKSSHIII FFFVQIIKKK SLRRRRGGPP MMIQSLDDGR LLLYTTNNSL FWWWSF-PEE IIMKSSHIII EEEVQVVKHH RLRRRRGGPP MMIQSLDDGR IIIYTTNNSL FWWWQFGQDD LLVKSSHMMM ---AYVVKRR KIEEEEGGPP MMLQSLDDGR LLLYTTTTSL YWWWQF-PEE HHVSAATMMM ---AYVVKRR QIEEEEGGPP MMLQSLDDGR LLLYSSTTSL YWWWQF-PEE NNVSAATMMM ---------- ------GGPP KKIQSVDDGR LLLYTTNNSF YWWWQF-PNN VVVESSVMMM EEEPFLLKRR RLLLLLGGPP MMLQSLDDGR LLLYSSSSSL FWWWQF-PEE MMVAGGTIII EEEAYVVKRR RLEEEEGGPP MMLQSLDDGR LLLYSSSSSL YWWWQF-PKK MMVQGGHIII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- MMVSSWDDGR VVVYSSSSSL LWWW------ ---KKKDDDD ---------- ---------- MMVSSWDDGR LLLYTTSSSL LWWW------ ---KKKDDDD A-----PSSS GGGGGGEIDD DEEFFDDFGG E--------R RSHQVVRLSG GGGSSSDDSS V-----PEEE GGGGGGELEE EEEFFDDFGG R--------R RAHQVVRLWG GGGSSTDDSS A-----PDDD GGGGGGTLAA ADDYWEEFPP DGG------R RAHQIIRLEG GGGSSTDDSS V-----GNNN GGGGGGELDD DDDYFSSFPP DGG------R RAHQIIRLEG GGGSSTDDSS V-----ENNN GGGGGGTLDD DDDFWDDFPP AGG------R RSHQIIRLEG GGGSSTDDSS A-----PNNN GGGGGGEFDD DKKFFEEWPP KGG------R RPHQVVRLQG GGGSSSDDSS V-----PDDD GGGGGGQFDD DNNFFDDFGG E--------R RVHQIIRLQG GGGSSSDDSS A-----PGGG GGGGGGSLDD DGGFFEEVGG DGG------R RPHQIIRLEG GGGSSSDDSS QDDVTTVNNN GGGGGGKLNN NNNFLDDFGG KEEPLGGGPL LAHELLRYPG GGGSSSDDII QDDVTTANNN GGGGGGKLNN NNNFLDDFGG KEEPLGGGPL LAHELLRYPG GGGSSSDDII QDDVTTVKKK GGGGGGKLNN NNNFLDDFGG KEEPLGGGPL LAHELLRYPG GGGSSSDDII QDDVTTVKKK GGGGGGTLNN NNNFLDDFGG KEEPLGGGPL LAHELLRYPG GGGSSSDDII QDDVTTVKKK GGGGGGKLNN NNNFLDDFGG KEEPLGGGPL LAHELLRYPG GGGSSSDDII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QDDVTTVKKK GGGGGGKLNN NNNFLDDFGG KEEPLGGGPL LAHELLRYPG GGGSSSDDII QDDVTTVKKK GGGGGGKLNN NNNFLDDFGG KEEPLGGGPL LAHEIIRYPG GGGTTSDDII ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QDDVTTEKKK GGGGGGKLNN NNNFLDDFGG KEEPGGGGPL LAHELLRYPG GGGSSSDDII QDDVTTKKKK GGGGGGKLNN NNNFLDDFGG KEEPDGGGPL LAHEIIRYPG GGGTTSDDII QDDVTTEKKK GGGGGGKINN NNNFFDDFGG AEEPDGGGPL LAHEMMRYPG GGGTTSDDII QDDVTTENNN GGGGGGKINN NNNFFDDFGG AEEPDGGGPL LAHEMMRYPG GGGTTSDDII QDDVTTEKKK GGGGGGSINN NNNFFDDFGG DEEPEGGGPL LAHEMMRYPG GGGTTSDDII QDDGTTEKKK GGGGGGTINN NDDFFDDFGG DEEPDGGGPL LAHEMMRYPG GGGTTSDDII QDDVTTEKKK GGGGGGSINN NNNFFDDFGG AEEPEGGGPL LAHEMMRYPG GGGTTSDDII QNNIPPESSS GGGKKKEINN NDDFLDDFGG KIIEGGGGPL LAHEMMRYPG GGGTTSDDII QDDVPPITTT GGGHHHVINN NNNFLDDFGG KVVPGGGGPL LAHEMMRYPG GGGTTSDDII QDDVTTEKKK GGGGGGTVNN NNNFLDDFGG KEEPNGGGPL LAHDIIRFPC CGGTTSDDII QDDIVVENNN GGGGGGKLNN NNNFLDDFGG GEEPYGGGPL LPHEMMR--- ---------- LDDVTTVNNN GGGGGGSLNN NDDFLDDFAA NEEPYGGGPL LPHEMMRYPG GGGTTSDDII ---------- ---------- ---------- ---------- ---------- ---------- QLLKYYNWWW DDDGGGELVV VDDFADDFYY ELLGLGGG-R RAHIMMRFGS SSSYYSSS-- QLLKYYYWWW DDDGGGELKK KQQFADDFYY AEEKLGGG-R RPHQMMRFGA ARRYYAGGPP YP----- FP----- FPV---- FPV---- FPV---- YP----- YP----- YP----- W------ W------ W------ W------ W------ ------- ------- W------ W------ ------- ------- ------- W------ W------ W------ W------ W------ W------ W------ W------ W------ L------ ------- WNA---- ------- ------- AGRQAVE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MMMMNSAAKA PSSATTPPCR TTVTGAALLD GGAMSLPPPR RTTAQLLLLL LTTPPGSPVR gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IIIKAYEWWT TTSSSIQVVL AASSSSSEEE KGRTTTTSSS VPPPGGEAVV QVVSSAVWHH ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------EE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------PP ---------- ---------- ---------- ---------- ---------- -------LGG ---------- ---------- ---------- ---------- ---------- ---------- -----MGAAP PPLLPLNNNR TTPTTPPNNN LAPSSSSPPP HPPPRRLVRR RTIVVPLCVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------FF ---------- ---------- ---------- ---------- ---------- --------VV ---------- ---------M AIIIIVVPPK RRDDPPTTFY YPSPKAAAPP PELLAYVVLY ---------- ---------- -MMMMAAKKK PPDDPPTTFY YPTPRAAAPP PEIIAYVVLY ---------- ---------- -----MMSSR PPDDPPTTFH HASPEAAAPA AEFFAYTTLS ---------- ---------- -----MMTTR PPDDPPTTFH HASPKAAAPA AEFFAYTTLS ---------- ---------- -----MMTTR PPDDPPTTFY YPSAKAAAPV VELLAFTTLS ---------- ---------- -MMMMAATTK PPDDPPSSFY YPSPRAAAPP PEIIAYVVFD ---------- ---------- -MMMMVVTTR PPDDPPTTFY YPSPRAAAPA AELLAYVVLN ---------- ---------- -MMMMAASSR PPDDPPTTFY YPSPKAAAPR RELLGYVVLD ---------- -------MAT KCCCCTTKK- CCGGPPGGYP PTPLEMMMPR REIIVYLLIY ---------- ---------- ---------- ---------- --------PR REIIVYLLIY GAAALIIIAA APPRL--HST QCCCCGGKK- CCGGPPGGYP PSPLEMMMPR REIIVYLLIY ---------- ---------- ---------- ---------- -----MMMPR REIIIYLLIY ---------- -------MAT KCCCCGGNN- CCGGPPGGYS STPLEMMMPR REIIVYLLIY GAAALQQQSS SVVQMAATAT KCCCCGGNN- CCGGPPGGYS STPLEMMMPR REIIVYLLIY ---------- -------MAT KCCCCGGNN- CCGGPPGGYS STPLEMMM-- ---------- ---------- -------MAT KCCCCGGNN- CCGGPPGGYS STPLEMMMPR REIIVYLLIY GHHHQPPPWW WFFSQEETAT KCCCCGGDD- CCGGPPGGYP PTPQEMMMPR REIIVYLLIY FDDDNTTTEE ELLTCFFSPT KCCCCGGNN- CCGGPPGGYS STPLEMMMPR REIIVYLLIY ---------- -------MAT KCCCCGGNN- CCGGPPGGYS STPLEMMMPR REIIVYLLIY LQQQMEEEGG GAAAEAANGK TCCCCCCHHA KKGGPPGGYA ATPLEMMMPR RELLVYVVVY ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------MA KCCCCGGSS- CCGGPPGGYK KSPLDMMMPR REIIVYLLIY ----MAAATT TVVDGEEKS- VNNNNGGCCK SSGGPPGGYA ASPIEMMMPR RELLIYVVVY ----MGGGTT TVVQAEEVNN QQQQQGGCCK SSGGPPGGYA ASPLEMMMPR RELLIYVVVY ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -RRRRMMLLV GGGGPPGGYA ATPLAMMMPS SELLIYVVVY ---------- -----AANGA ACCCCCCGGA TTGGPPGGYA ATPLEMMMPR RELLLYVVVY ---------- -----PPCGL KCCCCHHGG- --GGPPGGYA ASPADIIIPR REVVLFVVP- ---------- -------CPL KCCCCHHGG- --GGPPGGYA ASPADIIIPR REVVLFVVP- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M SEEEESSKKK CCGGPPGGYA ATPLDVVVPV VELLLYVVVQ ---------- ---------- ---------- ---------- -----MMMPR RELLLYTTVQ ---------- ---------- ---------- --MMPPGGLI IT--DLLLDD DRLLYFSSLH G--------- ----L--LAM GLLLLPPFFA FFAADDEETC CQSPYPPPGQ QEFFVYVVLG SGGGMHHHFF FAARLLLLAL AAAAAPPAAV RRAADDEETC CASPYKKKGQ QEYYVYVVLG YTTGTTIFVN PPKTYYYSSK VHKKVVEEPY NDDDELLHHH HFGWNAAACS SSSSSSAAL- YVVGTTVFVD PPKTYYYGGK IYKKLLDDPY GDDDELLHHH HFGWNAAACS SSSSSSAAY- SPPDFF-AIK PPGTYYYGGK VHTTVVTTPN GDDDEFFHHH HFGWNAAACS SSSSSSSSL- SPPDFF-AIK PPGTYYYGGQ VHTTVVTTPN GDDDEFFHHH HFGWNAAACS SSSSSSAAL- SPPDAA-GVD PPTKFFFGGQ VHQQLLIIPN GDDDEFFHHH HFGWNAAACS SSSSSSAAL- DPPERR-AVD PPARYYYAAS VGQQVVAAPH GDDDELLHHH HFGWNAAACS SSSSSSCCL- NPPMAAGAVD SSQTFFFGGQ VGVVTTDDPY GGGGELLHHH HFGWNAAACS SSSSSSMML- DPPGRR-ALD PPDTYYYAAQ VGRRVVEEPN ADDDELLHHH HFGWNAAACS SSAAAAAAL- YRRNTTTYVD PPKQYYYSSQ IHRRLLPPPY KDDDELLHHH HSGWNTTTCS SSSSSSCC-- YRRNTTIYVD PPKHYYYSSQ IHRRLLPPPH KDDDELLHHH HSGWNTTTCS SSSSSSCC-- YGGNTTIYVD PPKQYYYCCQ IHRRLLPPPN RDDDELLHHH HSGWNAAACS SSSSSSCC-- YRRNTTIYVD PPKQYYYCCQ IHRRLLPPPH KDDDELLHHH HSGWNTTTCS SSSSSSCC-- YRRNTTTYVD PPKQYYYCCQ IHRRLLPPPN KDDDELLHHH HSGWNTTTCS SSSSSSCC-- YRRNTTTYVD PPKQYYYCCQ IE-------- ---------- ---------- ---------- ------TYVD PPKQYYYCCQ IHRRLLPPPN KDDDELLHHH HSGWNTTTCS SSSSSSCC-- YRRNTTTYVD PPKQYYYCCQ IHRRLLPPPN KDDDELLHHH HSGWNTTTCS SSSSSSCC-- YRRNTTTYVD PPKQYYYSSQ IHRRLLPPPY KDDDELLHHH HSGWNTTTCS SSSSSSCC-- YRRNTTTYVD PPKQYYYCCQ IHRRLLPPPN KDDDELLHHH HSGWNTTTCS SSSSSSCC-- YRRNTTTYVD PPKQYYYCCQ IHRRLLPPPN KDDDELLHHH HSGWNTTTCS SSSSSSCC-- YNNGTTIYVD PPSTYYYSSQ IHRRLLPPIH GDDDKLLHHH HSGWNSSSCS SSSSSSCC-- ---------- ---------- --------PN NDDDELLHHH HSGWNTTTCS SSSSSSCC-- YRRSTTIYVD PPKSYYYSSQ IHRRLLPPPN NDDDELLHHH HSGWNTTTCS SSSSSSCC-- YAAGTTIYVD PPSTYYYSSK IHRRLLPPPY GDDDELLHHH HTGWNSSSCS SSSSSSCC-- YAAGTTIYVD PPNTYYYSSK IHRRLLPPPY GDDDELLHHH HTGWNSSSCS SSSSSSCC-- ---------- ---------- --------PF GDDDELLHHH HSGWNSSSCS SSSSSSCC-- YTTGTTIYVD PPSSYYYSSS IHRRLLPPPF GDDDELLHHH HSGWNSSSCS SSSSSSCC-- YNNGTTIYVD PPNTYYYSSQ IHRRLLPPTH GDDDELLHHH HSGWNAAACS SSSSSSCC-- ----NNAAVN PPETFFFCCQ ISRRVVDDPH GDDDEVVHHH HTGWNAAACS SSSSSSCC-- ----HHRAVN PPETFFFCCQ ISRRVVDDPN GDDDEVVHHH HTGWNAAACS SSSSSSCC-- ---------- ---------- ---------- ---------- ---------- ---------- QPPNLLEYVD PPATYYYCCQ IHRRTTYYNS HNNNELLHHH HSGWNTTTCS SSSSSSCCHV QPPNLLEYVD PPETYYYCCQ VHRRTTFFNR GDDDELLHHH HSGWNAAACS SSSSSSCCYV HGGDIIQDPV GGQLGGGGGS LKDDGGPPKV EDDDKEELLD DSQPTPPPRI IILLLLKK-- GVVEGGGKIR PPGTRRRGGQ INSSVVSSGG RNNNEAAHHH HGGFSAAA-- ---------- GAAEGGGKVN PPKQYYYGGK VNTTLLSSGG RNNNEAAHHH HSDFTDDD-- ---------- --KKKPPERR RFLGGLRRYI IDTKPNPPRR RRPKIKIIEP EEKKYRRLVH CGAYIIAALN --KKKPPERR RYLAALRRYI IDTKPDKKRR RRPAVKVVEP EVVVYKKYVH CGAYIIAALG GGHHHAAERR RFLGGLRRYV VDTKPHPPTT TTARIKIIEP DELLYRRPVH CGGYVVTTLG GGHHHAAERR RYLGGLRRYI IDTKPDPPTT TTAKIKIIEP EEFFYRRPIH CGGYVVTTLG GGHHHAAERR RYLGGIRRYI IDVK-EPPLL LLAKIKIIEP EEFFYRRPIH CGGYVVTTLG PPHHHPPERR RYLGGLRRYI IDTKPDPPLL LLPFLKIIEP ETAAYRRPVH CGGYVVAALN PPHHHPPERR RYLDDIRHTI IDTKPDPPTT TTPKVKIIDP NEAAYRRPVH CGGYIIAALS PPHHHPPERR RYLGGIRRHI IDTKPDPPRR RRPRIKIIEP EEHHYRRPIH CGGYVVAALS GGDDDSSSRN NKLGGLMRYV VDVGSEPPRR RRPKLKIIEA SEQQVNNTSH CLGVMMNNTG GGDDDSSSRD DKLSSIIRYV VDVGSEPPRR RRPKLKIIEP NEHHLNNLSH CLGVMMSSSG GGDDDSSSRT TKLCCLMRYV VDVGSDPPRR RRPKLKIIEA EDHHLYYVSH CLGVMMSSTG GGDDDIIART TKLAALIRYV VDVGTEPPRR RRPKLKIIEP KDHHLFFFSH CLGVMMSSTG GGDDDSSSRT TKLSSLIRYV VDVGSEPPRR RRPKLKIIEP EDHHLFFLSH CLGVMMSSSG ---------- ---------- ---------- ---------P KDHHLFFLSH CLGVMMSSSG GGDDDSSSRT TKLSSLIRYV VDVGSEPPRR RRPKLKIIEP KDHHLFFLSH CLGVMMSSSG GGDDDSSSRT TKLSSLIRYV VDVGSEPPRR RRPKLKIIEP KDHHLFFLSH CLGVMMSSSG GGDDDSSSRN NKLSSFIRYV VDVGTEPPRR RRPKLKIIEA KDHHLTTPSH CLGVMMSSTG GGDDDSSSRT TKLSSL---- ---------- ---------- ---------- ---------- GGDDDSSSRT TKLSSLIRYV VDVGSEPPRR RRPKLKIIEP KDHHLFFLSH CLGVMMSSSG GGDDDPPKRR RFLSSLLRYV VDTATDPPRR RRPSLKVVES EDAALFFPSH CLGIMMSSCG GGDDDAAVRN NKLCCLIRYV VDVGTDPPRR RRPRIKVVEP YEFFLNNLSH CLGIMMSSSG GGDDDSSVRN NKLCCLIRYV VDVGSDPPRR RRPRIKVVEP YEFFLNNPSH CLGIMMSSSG GGDDDPPERR RFLSSLVRYV VDTKTNPPRR RRPSLKVVDP ADIILYYPSH CLGLMMSSCG GGDDDPPQRR RFLGGIVRYV VDTKTNPPRR RRPSLKVVEP EDSSLYYPSH CLGIMMSSCG GGDDDAADRR RYLSSLIRYA ADTKENPPRR RRPSLKVVDP KEAALYYPAH CLGILLSSCG GGDDDAADRR RYLSSLIRYA ADTKENPPRR RRPSLKVVDP KEAALFFPAH CRGILLSSCG GGDDDPPSRR RFLSSLLRYV VDTLKDPPRR RRPALKVVEA EDAALFFPSH CLGIMMSSCG DDKKKPPKRS SHLCCLNRYI INVENE--RR RRIYLHIIEP SKHHLFFPSH CLGIMMSSTG DDKKKPPKRS SHLCCLNRYV VNVENE--RR RRIYLHIIEP SKHHLFFPSH CLGIMMSSTG ---------- --MKKLSVGK KFVGG----- ---------- ---------- ---------- GGKKKEETRD DRLCCLNRFV VDTGTDPPRR RRPKLKIIEG -DLLCAAPTH CLGIMMSSIG SSKKKTTKRD DRLSSLNFYI IDVVTDPPRR RRPEIKIIDG -DLLVAAPTH CLGIMMSSVG GGKKKRRGGP PQMSSLDRYV VTSLYSAAWW WWKQFP---- -DIILIISAD YQTLKKDDGN -------DRR RFFGGLDRFI IDVHSDPPSS SSPKLKIIDT -FKKVGGPFF ALSMIIGGLN -------DRR RYLGGLDKFV VDVHSDPPAA AAPVLKIITD -FEEVGGPLY ALRLIIGGLN NEE--EEG-G PPGIILLLHY EPLKKKEEEI RGGGD----- --LAAAYDDF FWWWWN-NLV GPP--DDGRG PPGIILLLHD EPIRRREEEV RGGGP----- --FAAAYDDF FWWWWN-SMI GAAGKDDGTG AAGIIMMMCE DVLRRREEEI RGGGP----- --KHHHYDDF FWWWWN-RMV GGGGKDDGTG PPGVVMMMCE EVLRRREEEI RGGGP----- --LHHHYDDF FWWWWN-RMV GGGGEDDGTG PPGIILLLCE EILRRREEEM RGGGE----- --KHHHYDDF FWWWWN-RMV NAA--EEG-G PPGIILLLAQ EPLRRREEEV RGGGP----- --FAAAYDDG GWWWWH-YLV SPP--EEG-G PPGIILLLHD EVLRRREEEI RGGGD----- --LHHHYDDF FWWWWH-YLL SPP--EEG-G PPGVVMMMHE DPLRRREEEV RGGGP----- --LAAAYDDF FWWWWH-YMV GDD--LLQGG KKSFFLLLGE EVKTTTEEEK GGGGA----- --MGGGYDDF FYYYYQ-HMV GDD--PPQGG KKGFFLLLGE EVKTTTEEEK GGGGE----- --MGGGYDDF FYYYYQ-HMV GDD--SSKGG KKGFFLLLGE EVKTTTEEEQ GGGGA----- --MGGGYDDF FYYYYQ-HMI GDD--PPEGG KKGFFLLLGK EVKTTTEEEQ GGGGA----- --LGGGYDDF FYYYYQ-HMI GDD--VVKGG KKGFFLLLGE EVKTTTEEER GGGGA----- --SGGGYDDF FYYYYQ-HMI GDD--VVKGG KKGFFLLLGE EVKTTTEEER GGGGA----- --LGGGYDDF FYYYYQ-HMI GDD--VVKGG KKGFFLLLGE EVKTTTEEER GGGGA----- --LGGGYDDF FYYYYQ-HMI GDD--VVKGG KKGFFLLLGE EVKTTTEEER GGGGA----- --LGGGYDDF FYYYYQ-HMI GDD--PPKGG KKGFFLLLGE EVKTTTEEER GGGGS----- --MGGGYDDF FYYYYQ-HMI ---------- ---------- ---------- ---------- ---------- ---------- GDD--VVKGG KKGSSLLLP- ECS------- ---------- ---------- ---------- GDD--KKEGA AANGGLLLDS NVKRRRSSSN LFFFP----- --KEEERTTH HYYYYEYWFW GDD--PPYGG KKGFFLLLGE EVKNNNEEEA GEEEA----- --FGGGYDDF FYYYYQ-HMI GDD--PPCGG KKGFFLLLGE EVKNNNEEEV GEEES----- --FGGGYDDF FYYYYQ-HMI GDD--KKDGA EENGGLLLDS NVKRRREEEK GHHHS----- --FGGGYDDF FYYYYQ-HMI GDD--KKDGA EENGGLLLDS NVKRRREEEK GHHHS----- --FGGGYDDF FYYYYQ-HMI GDD--EEEGA KKNGGLLLDS NIKRRREEEK GHHHS----- --FGGGYDDF FYYYYQ-HMI GDD--EEEGA KKNGGLLLDS NIKRRREEEK DIIIS----- --YGGGYHHF FYYYYQ-HMI GDD--KKEGA AANGGLLLDS NVKRRREEEK GHHHS----- --FGGGYDDY YYYYYQ-HMI GEE--AANGP SSNFFLLLGK EPKTTTPPPA EKKKT----- --FNNNYDDF FYYYYQ-RMI GEE--AADGP SSNFFLLLGK EPKTTTPPPA GKKKV----- --FNNNYDDF FYYYYQ-RMI ---------- ---------- ---------- ---------- ---------- ---------- GDD--AAEGA KK-DDEEEDK ELVTTTSSSR DRRRK----- --CGGGYDDY YYYYYQ-FMV GDD--AAEGA KK-DDLLLDS NCITTTTTTK DKKKK----- --CGGGYDDF FYYYYQ-FMV NEE--SSLSP VVNGGTTTKH GLSKKKEEEA QFFFE----- --LQQQLSSN NNNNNN-RSE NDD--DDDHG RRALLYYYDD YVAYYYMMMP ADDDDAAVGD ADYGGGYDDI IAAAAL-KML NNN--KKDHG RRALLYYYNA YVAHHHIIIP DGGGDAATG- ADYDDDYDDV VAAAAL-KLV SSSEVP--EG GGKKKLELK- YGGNNNRFFW DDDLLRTEEE RRMML---EE RPLHDPPPKK TTSEVP--EG GGSSSLELKG YGGNNNKVVW DDDLLRDQQE RRMML---EE RPLHDPPPKK SSSELP--EG GGVVVPELLN YGGHHHRFFW DDDLLRDAAQ QQMML---EE RPAHDPPPRR TTSELP--EG GGVVVPELLN YGGHHHRFFW DDDLLRDAAN QQMML---EE RPAHDPPPRR SSSELP--EG GGVVVPELLN YGGHHHKFFW KKKLLRDAAN QQMML---EE RPAHDPPPKK TTSETP--EG GGVVVPDLLA YGGRRRRFFW DDDLLRDDDE QQLLF---EE RPAHDPPPKK TTSETP--EG GGLLLGDLLG YGGHHHRVVW DDDLLRDAAE QQMML---EE RPAHDPPPKK TTSETP--EG GGDDDPQLLK YGGRRRRIIW DDDLLRDEEE QQMML---EE RPAHDPPPRR SSTEAP--KG GGPPPAHEAG YGGSSSRVVW DDDWWHQ--- GGLLP---EE RFLHDPPPAA SSTEAP--KG GGPPPAHEAG YGGSSSHVVW DDDWWHQ--- GGLLP---EE RFLHDPPPAA SSTEAP--RG GGPPPADEAG YGGSSSHVVW DDDWWHT--- GGLLP---EE RFLHNPPPAA SSTEAP--RG GGPPPADKAG YGGSSSHVVW DDDWWRP--- GGLLP---EE RFLHNPPPAA SSTEAP--RG GGPPPADEAG YGGSSSHVVW DDDWWHS--- GGLLP---EE RFLHNPPPAA SSTEAP--RG GGPPPADEAG YGGSSSHVVW DDDWWHS--- GGLLP---EE RFLHNPPPAA SSTEAP--RG GGPPPADEAG YGGSSSHVVW DDDWWHS--- GGLLP---EE RFLHNPPPAA SSTEAP--RG GGPPPADEAG YGGSSSHVVW DDDWWHS--- GGLLP---EE RFLHNPPPAA SSTEAP--QG GGPPPADEAG YGGKKKHVVW DDDWWHL--- GGHHP---EE RFLHDPPPAA ---------- ---------- ---------- ---------- ---------- ---------- --AIHS--LG GGDDDYPSAS VAAGGGI--- ---------- ---------- ---------- SSWICS--TG GGLLLMCTAS VHHVVVILLD NNNYYRP--- QQAAANPICC RSIHWKKKII SSTEAP--AG GGMMMEEQAG YGGHHHSVVW DDDWWHDEE- GGLLP---EE RFLHDPPPAA SSTEAP--AG GGMMMEDQAG YGGHHHSVVW DDDWWHDKK- GGLLP---EE RFLHNPPPAA SSTSAP--TG GGLLLQHADG YGGRRRHCCI QQQLLGDNN- GGLLP---EE RFLHDPPPKK SSTSAP--LG GGLLLQHADG YGGRRRHVVY SSSWWGDDD- GGLLP---EE RFLHDPPPKK SSTSAP--SG GGLLLQHADG YGGSSSHVVY SSSWWGDEE- GGLLP---EE RFLHDPPPKK SSTSAP--SG GGLLLQHADG YGGSSSHVVY SSSWWGDPP- GGLLP---EE RFLHDPPPKK SSSSAP--RG GGLLLQHQDG YGGRRRHVVY DDDWWGDSS- GGLLP---EE RFLHDPPPKK SSTESP--KG GGPPPAHGEG YGGNNNSIIF EEEWWKDQQP GGAAP---EE RFLHEPPPSS SSTESP--KG GGPPPAHPEG YGGNNNSIIF EEEWWKDMMP GGAAP---EE RFLHEPPPSS SSILGP--CD DDLLLKCPEP VIIKKKCVVY ---------- ---------- ---------- AASEAP--RG GGPPPTDDDT YGGCCCRFFY RRRWWRDDD- GGLLP---EE RFLHNPPPEE SSSEAP--RG GGNNNVDEDS YGGCCCRFFY KKKWWQDSS- GGIIP---EE RFLHNPPPKK SSDREP--FS SSSSSFLKTP KPPQQQHEEV LLL------- ---------- ---------- TTSSGWNNDG GGLLLQDEAK FGGNNNTQQW DDDLLRNGGA --------EE RFPWGSSSAA TTSSGWNNDG GGLLLADEAK FGGNNNTTTW DDDLLKDGGA --------EE RCAWGEEEHH LMGFFFFNVV VVKLLLSWWL LY---EEGWW WEEEIEELNL LLPEILLKPP PPVIDIIDDK LMGFFFFNVV VLKLLLSWWL LY---EEGWW WEDDIQQFPL LLPPVLLKDP PPVIDIIDDR EYGFFFFGVV VVTLLLGWWT TR---EEGFF FKTTIEEAEL LLPPLLLQGP PPVIDLLDDR EYGFFFFGVV VVTLLLAWWT TR---EEGFF FETTIEEAKL LLPPLLLQGP PPVIDLLDDR DYGFFFFGVV VVTLLLGFFT TQKKKDDGFF FKTTIVVADL LLPDLLLKGP PPVIDLLDDK AYGFFFFNVV VIKLLLSWWT TR---DDDWW WREEIEEAQL LLPPVLLKGP PPVIDLLDDR AYGFFFFNVV VVKLLLAWWL LR---DDGWW WKDDIEEAQL LLPPILLKPP PPVINLLDDR TYGFFFFGVV VVELLLAWWL LR---QQGWW WREEIEEAQL LLPPLLLKDP PPVINLLDDR TQGFFFFGAA ALNQQQFNNE E--------- --WWSKKISK KKKVKGGWMP PGIILLLDDR TQGFFFFGAA ALNQQQFNNE E--------- --WWSKKISK KKKVKGGWMP PGIILLLDDR AQGFFFFGAA ALTQQQFNNQ Q--------- --WWSKKIPK KKKVKGGWMP PGIILLLDDR AQGFFFFGAA ALTQQQFNNE E--------- --WWSKKIPK KKKVKGGWMP PGIILLLDDH AQGFFFFGAA ALTQQQFNNE E--------- --WWSKKIPK KKKVKGGWLP PGIILLLDDR AQGFFFFGAA ALTQQQFNNE E--------- --WWSKKIPK KKKVKGGWLP PGIILLLDDR AQGFFFFGAA ALTQQQFNNE E--------- --WWSKKIPK KKKVKGGWLP PGI------- AQGFFFFGAA ALTQQQFNNE E--------- --WWSKKIPK KKKVKGGWLP PGIILLLDDR SQGFFFFGAA ALTQQQFNNE E--------- --WWSKKIPK KKKVKGGWMP PGIILLLDDR ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- NQDYYYYVEE EVSRRRGPPD D--------- --VVVRRLYA AAVVAKKFGS SNFAWIIDDL AQGLLLLGAA ALTFFFFEEK K--------- --WWAKKISK KKKVEGGWAP PGIILIIDDR DQGLLLLGAA ALSFFFFEEK K--------- --WWAKKISK KKKVEGGWPP PGIILIIDDR DTGFFFFGAA ALNIIIFTTQ Q--------- --WWSLLIPL LLKVQNNWIP PGIFLIIDDR DTGFFFFGAA ALNIIIFTTQ Q--------- --WWNIIIPL LLKVQNNWFP PGIFLIIDDR DTGYYYYGAA ALNIIIFNNS S--------- --WWSIIIPL LLKVENNWIP PGIFLIIDDR DTGFFFFGAA ALNIIIFNNS S--------- --WWSVVIPL LLKVENNWIP PGIFLIIDDR DTGYYYYGAA ALNVVVFTTA A--------- --WWSVVIPL LLKVRNNWIP PGIFVIIDDR EHAFFFFGAA ALGFFFIVVE ES-------- --HHALLASK KKKVSGGWAP PAIILIIDDR EHAFFFFGAA ALAFFFIDDE EP-------- --QQTLLASK KKKVENNWAP PAIILIIDDR ---------- ---------- ---------- ---------- ---------- ---------- NQGYYYYGAA AFXXXXX--- ---------- ---------- --QGENNGEG GGMILIIDDR AEGFFFFGAA ALKFFFFKKS SD-------- --AAKIIILV VVDTGSSGVG GGIIIIIDDR ---------- ---------- ---------- ---------- ---------- ---------- NYAFFFFTAA ALQWWWIDDD D--------- --------AK KKAVADDIGI IPPISIIDDQ NYCFFFFSAA ALQWWWIDDG G--------- --------AK KKAVADDIGV VPPISIIDDS KLYYYLLGEV RRRRQYDDIS NFFKKKPPTK GGIFFHHRRA ADDHH----- ---------- RLYYYLLGEL RRRRQYDDIT NHHQQQPPAK GGLYYHHRRE EPPHH----- ---------- RLYYYCCGEM RRRRQYDDVS DHHNNNPPAR GGIAARRRRA APPHH----- ---------- RLYYYCCGEM RRRRQYDDVS DRRKKKPPAH GGIAARRRRT TPPHH----- ---------- KLYYYCCGEM HHHHQYDDVS DMMNNNPPTE GGIVVKKKKT TPPHH----- ---------- RLYYYCCGDL LLLLQYDDVS DFFEEEPPTR GGIVVSSRRA ATTHH----- ---------- RLYYYCCGEL HHHHQYDDVS DFFNNNPPTQ GGIVVRRRRA AGGHH----- ---------- RLYYYCCGEL RRRRQYDDVS DFFNNNPPTR GGIVVRRKKA AAAHH----- ---------- RLYYYNNGDI RRRRQYDDIS NQQKKKPPTF GGSIIVVRRG GGGSSVVLLL EE-ELLTCPP RLYYYNNGDI RRRRQYDDIS NKKKKKPPTF GGSIIVVKKG GGGSSVVLLL EE-ELLTCPP RLYYYNNGDL RRRRQYDDIS DQQRRRPPTF GGSIIVVKKG GGGPPVVLLL EE-ELLKSPP HLYYYNNGDI RRRRQYDDVS DQQRRRPPTF GGSIIVVKKD DGGPPVVLLL DD-ELLDSPP RLYYYNNGDL RRRRQYDDIS DQQRRRPPTF GGSIIVVKKG GGGPPVVLLL EE-ELLKSPP RLYYYNNGDL RRRRQYDDIS DQQRRRPP-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- RLYYYNNGDL RRRRQYDDIS DQQRRRPPTF GGSIIVVKKG GGGPPVVLLL EE-ELLKSPP RLYYYNNGDM RRRRQYDDIS DKKRRRPPVF GGSIIVVKKG GGGPPVVLLL EE-ELLKSPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LIIIISS--- ---------- ---------- ---------- ---------- ---------- RLYYYNNGDI RRRRQYDDIT DRRNNNPPVF GGSIILLRRG GGGPPVVLLL EE-DLLECPP RLYYYNNGDI RRRRQYDDIT DRRNNNPPVF GGSIIQQRRG GGGPPVVLLL EE-ELLECPP RLYYYNNGDI RRRRQYNNIE DKKNNNPPTW GGLIIQQKKG GSSPPAAIII GG-GKKTWSS RLYYYNNGDI RRRRQYNNIE DKKNNNPPTW GGLIIQQKKG GSSPPAAVVV KK-GEETWSS RLYYYNNGDI RRRRQYNNIE DKKNNNPPTW GGLLLQQKKG GSSPPAAVVV GG-GNNSFFF RIYYYNNGDI RRRRQYNNIE DKKNNNPPTW GGLLLQQKKG GSSPPAAVVV GG-GNNTFFF RLYYYNNGDI RRRRQYNNIE DAAKKKPPAW GGLLLQQKKG GSSEEYYVVV TT-DKKEEYY RLYYYCCGDI RRRRQYDDIS DLLKKKVVNY GGSVVHHTTE ESSNNVVLLL EE-K----II RLYYYCCGDI RRRRQYDDIS DKKNNNPPNF GGSIIHHSSE ETTTTVVLLL EE-HDD--II ---------- ---------- ---------- ---------- ---------- ---------- RLYYYNNGDV RRRRQYDDIS DAANNNPPTF GGAIIQQRRD DAAPPVVLLL NN-ELLKEPP RLYYYCCGDV RRRRQYDDIT DEENNNPPTF GGAIICCSSD DLLPPIIVVV KKEELLKEPP ---------- ---------- ---------- ---------- ---------- ---------- QLWWWSSGKT RRRRLFDDIS DHHKKKPPIV DDQVVNN--- ---------- ---------- SLWWWTTGKT RRRRLFDDIS DHHHHHPPVT GGQVVNN--- ---------- ---------- ------GGGG HKKKLTGALE EEIIDDDDRR VVVVYVTTSS YTWNNFFFYY YYYKKKKWWW ------GGGG AEEEATGAIS SSVVDDDDRR VVVVYITTSS YSWNNFFFYY YYYRRRRWWW ------GGGG RTTTFAGGVE EEIIDDDDRR VVVVYWTTSS YTWDDFFFYY YYYPPPPAAA ------GGGG KAAAFAAGVE EEIIDDDDRR VVVVYWTTSS YTWDDFFFYY YYYPPPPVVV ------GGGG KTTTFGYGVE EEIIDDDDKK VVVVYWTTSS YTWEEFFFYY YYYGGGGAAA ------NNNN GAAALNGGVE EEIIDDDDRR VVVVYFTTSS YAVPPFFFYY YYYDDDDWWW ------SSSS AEEELNGGVE EEIIDDDDRR VVVVYFTTSS YAWEEFFFYY YYYKKKKWWW ------SSSS GPPPLNGGVE EEVVDDDDRR VVVVYFSSSS YSWEEFFFYY YYYRRRRWWW PPPVVVGGGG KRRRIPGGIQ QQLLDDDDKK LLLLYATTSS YDWKKFFFYY YYYIIIIEEE PPPVVVGGGG KRRRVPGGIQ QQLLDDDDKK LLLLYVTTSS YAWKKFFFYY YYYIIIIEEE PPPVVVGGGG KKKKVPGGIQ QQLLDDDDKK LLLLYVTTSS YAWKKFFFYY YYYIIIIEEE PPPVVVGGGG KQQQVAGGIQ QQLLDDDDKK LLLLYVTTSS YAWKKFFFYY YYYIIIIEEE PPPVVVGGGG KRRRVAGGIQ QQLLDDDDKK LLLLYITTSS YAWKKFFFYY YYYIIIIEEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPPVVVGGGG KRRRVAGGIQ QQLLDDDDKK LLLLYITTSS YAWKKFFFYY YYYIIIIEEE PPPVVVGGGG KRRRVPGGIQ QQLLDDDDKK IIIIYVTTSS YDWKKFFFYY YYYIIIIEEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PPPIIIGGGG KKKKVPGGIQ QQLLDDDDKK LLLLYVTTSS YKWKKFFFYY YYYIIIIEEE PPPTTTGGGG KIIIIPGGIQ QQLLDDDDKK IIIIYVTTSS YIWKKFFFYY YYYLLLLEEE SVVEEEGGGG QKKKLRGGIQ QQLLDDDDKK LLLLYVTTSS FAWKKFFFYY YYYVVVVKKK SVVEEEGGGG KKKKLRGGIQ QQLLDDDDKK LLLLYVTTSS FAWKKFFFYY YYYVVVVQQQ FVVQQQGGGG KSSSLRGGIQ QQLLDDDDKK LLLLYATTSS FAWRRFFFYY YYYMMMMKKK FVVQQQGGGG KSSSLRGGIQ QQLLDDDDKK LLLLYATTSS FAWVVFFFYY YYYMMMMKKK YVVQQQGGGG HRRRLRGGIQ QQLLDDDDKK IIIIYVTTSS FRWEEFFFYY YYYVVVVKKK IAAYYYGGGG RKKKIEGGLQ QQLLDDDDKK LLLLYVTTSS YKWDDFFFYY YYYVVVVSSS IAAYYYGGGG RQQQIEGGLQ QQLLDDDDKK LLLLYVSSSS YKWDDFFFYY YYYVVVVSSS ---------- ------GGIQ QQLLDDDDKK LLLLYVTTSS YTWKKFFFYY YYYVVVVEEE PPPFFFGGGG RRRRLLGGLQ QQLLDDDDRR LLLLYVSSSS FPWKKFFFYY YYYVVVVAAA PAAYYYGGGG RRRRLEGGLQ QQLLDDDDKK LLLLYVSSSS YPWKKFFFYY YYYVVVVQQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- --------VS SSQQDDDDKK VVVVYFSSSS LNW------- -------KKK ---------- --------VS SSSSDDDDQQ LLLLYYTTSS LNW------- -------KKK MMMVKLLNA- ---PSSGLLE IKKEEEFFFV VVDDDFFGGE ----ARSQVV SGGDSDDCY- MMMAKVVNV- ---PEEGLLE LKKEEEFFFV VVDDDFFGGR ----ARAQVV WGGDTDDCY- QQQVLAAHA- ---PDDGLLT LDDDDDWWWV VVEEEFFPPD G---YRAQII EGGDTDDCYS EEEVMAANV- ---GNNGLLE LKKDDDFFFV VVSSSFFPPD G---YRAQII EGGDTDDCYS MMMVMAANV- ---ENNGLLT LKKDDDWWWV VVDDDFFPPA G---YRSQII EGGDTDDCYS MMMVKLLDA- ---PNNGIIE FPPKKKFFFL LLEEEWWPPK G---HRPQVV QGGDSDDCY- MMMVKVVDV- ---PDDGMMQ FPPNNNFFFV VVDDDFFGGE ----QRVQII QGGDSDDCF- IIIAKAAEA- ---PGGGLLS LPPGGGFFFT TTEEEVVGGD G---LRPQII EGGDSDDCYS GGGSVMMLQD VVVVNNGLLK LPPNNNLLLV VVDDDFFGGK EPGPALAELL PGGDSDDI-- GGGSVMMLQD VVVANNGLLK LPPNNNLLLV VVDDDFFGGK EPGPALAELL PGGDSDDI-- GGGSVMMLQD VVVVKKGLLK LPPNNNLLLV VVDDDFFGGK EPGPALAELL PGGDSDDL-- GGGSVMMLQD VVVVKKGLLT LPPNNNLLLV VVDDDFFGGK EPGPALAELL PGGDSDDL-- GGGSVMMLQD VVVVKKGLLK LPPNNNLLLV VVDDDFFGGK EPGPALAELL PGGDSDDI-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGSVMMLQD VVVVKKGLLK LPPNNNLLLV VVDDDFFGGK EPGPALAELL PGGDSDDI-- GGGSVMMLQD VVVVKKGLLK LPPNNNLLLV VVDDDFFGGK EPGPALAEII PGGDSDDL-- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- GGGSVMMLQD VVVEKKGLLK LPPNNNLLLV VVDDDFFGGK EPGPVLAELL PGGDSDDV-- GGGAVMMLQD VVVKKKGLLK LPPNNNLLLV VVDDDFFGGK EPGPVLAEII PGGDSDDI-- GGGSHIILQD VVVEKKGLLK IPPNNNFFFV VVDDDFFGGA EPGPALAEMM PGGDSDDI-- GGGSHIILQD VVVENNGLLK IPPNNNFFFV VVDDDFFGGA EPGPSLAEMM PGGDSDDI-- GGGSHIIIQD VVVEKKGLLS IPPNNNFFFV VVDDDFFGGD EPGPALAEMM PGGDSDDI-- GGGSHIIIQD GGGEKKGLLT IPPDDDFFFV VVDDDFFGGD EPGPSLAEMM PGGDSDDI-- GGGSHMMLQD VVVEKKGLLS IPPNNNFFFV VVDDDFFGGA EPGPSLAEMM PGGDSDDI-- GGGATMMVQN IIIESSGMME IRRDDDLLLI IIDDDFFGGK IEGPYLAEMM PGGDSDDI-- GGGATMMLQD VVVITTGMMV IKKNNNLLLI IIDDDFFGGK VPGPYLAEMM PGGDSDDI-- GGGSVMMLQD VVVEKKGLLT VKKNNNLLLV VVDDDFFGGK EPGPCLADII PCGDSDDA-- GGGGTIIVQD IIIENNGMMK LEENNNLLLV VVDDDFFGGG EPGPGLPEMM ---------- GGGGHIIVLD VVVVNNGIIS LEEDDDLLLV VVDDDFFAAN EPGPSLPEMM PGGDSDDLAD ---------- ---------- ---------- ---------- ---------- ---------- GGGKDDDAQL KKKNWWDKKE LEEDDDAAAV VVDDDFFYYE LGG--RAIMM GSSASSS--- GGGKDDDEQL KKKYWWDKKE LEEQQQAAAI IIDDDFFYYA EKG--RPQMM GARAAGGGDN ------- ------- SSSVVR- SSSVV-- SSSVV-- ------- ------- SSS---- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- DDDAA-- ------- ------- NNNRRVQ 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNSSKAKKQE TPCRTAVVPT TGLTTAARLL AADDDGLLLL TTAAQQQLSL LTPSPPPVKK gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- YAAWTTFSSS SAQAASSPEE EEEKKGKSVV IIISSSAAAK KVVPAAVVVH HHHWLLLPPG ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------AER ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------M MMMGLLLGKE ---------- ---------- ---------- ---------- ---------K KKKNSSSQGC ---------- ---------- ---------- ---------- ---------- ---------- MRSAPPTLLL PPNTTTTPNN NNNLLAAPHP TTTRLLVVPY YIINPPLLLP PPPHAAARHS ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ----MMMKRR ---------- ---------- ---------- ---------- ---------- ----MMMKRF ---------- -----AIVVP FFFKKRPPFS SSPKMAAMMK APEEDDLYVV VCLLYTTTNN ---------- ------MAAK LLLKKPPPFT TTPRDAAMMR APEEDDIYVV VALLYVTTNN ---------- -------MMS MMMRRPPPFS SSPELAAMMQ APEEEEFYTT TLLLSPFF-- ---------- -------MMT MMMRRPPPFS SSPKLAAMME APEENNFYTT TLLLSPFF-- ---------- -------MMT LLLRRPPPFS SSAKLAAMME GPEEKKLFTT TMLLSPAA-- ---------- ------MAAT WWWKKPPPFS SSPRLAAAAK APEETTIYVV VMFFDPRR-- ---------- ------MVVT WWWRRPPPFS SSPRMAAVVK APEEKKLYVV VRLLNPAA-- ---------- ------MAAS WWWRRPPPFS SSPKMAAMMQ APEERRLYVV VLLLDPRR-- ---------- -----KCTTK -----CPPYP PPLEAMMKK- GPEEEEIYLL LCIIYRTTEE ---------- ---------- ---------- -------MM- GPEEEEIYLL LCIIYRTTEE KKHALARRRR GGLL-QCGGK -----CPPYP PPLEAMMKK- GPEEEEIYLL LCIIYGTTEE ---------- ---------- ---------- -----MMKK- GPEEEEIYLL LCIIYRTTEE ---------- -----KCGGN -----CPPYP PPLEAMMKK- GPEEEEIYLL LCIIYRTTEE AAEALSQQQQ PPMRAKCGGN -----CPPYP PPLEAMMKK- GPEEEEIYLL LCIIYRTTEE ---------- -----KCGGN -----CPPYP PPLEAMMKK- G--------- --------EE ---------- -----KCGGN -----CPPYP PPLEAMMKK- GPEEEEIYLL LCIIYRTTEE EEPHQWSSSS GGQLEKCGGD -----CPPYP PPQEAMMKK- GPEEEEIYLL LCIIYRTTEE LLGDNETTTT YYCTFKCGGN -----CPPYP PPLEAMMKK- GPEEEEIYLL LCIIYRTTEE ---------- -----KCGGN -----CPPYP PPLEAMMKK- GPEEEEIYLL LCIIYRTTEE LLVQMGAAAA VVETATCCCH TTTAAKPPYP PPLEAMMEEK GPEEKKLYVV VCVVYNTTNN ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----KCGGS -----CPPYP PPLDAMMKK- GPEEEEIYLL LCIIYRTTNN ----MTDDDD HHGVEVNGGC CCCKKSPPYP PPIESMMSS- GPEESSLYVV VAVVYATTEE ----MTQQQQ HHAVEQQGGC CCCKKSPPYP PPLEAMMSS- GPEETTLYVV VAVVYATTEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------RMML QQQVVGPPYP PPLAAMMSS- GPEEKKLYVV VAVVYTTTDD ---------- ---MAACCCG GGGAATPPYP PPLEAMMEEK GPEEKKLYVV VCVVYNTTNN ---------- ----PKCHHG ------PPYP PPADAIIKK- GPEEEEVFVV VAPP--NNDD ---------- -----KCHHG ------PPYP PPADAIIKK- GPEEEEVFVV VAPP--HHDD ---------- ---------- ---------- ---------- ---------- ---------- ---------- -----SESSK CCCKKCPPYP PPLDAVVRRN GPEEKKLYVV VCVVQPLLEE ---------- ---------- ---------- -----MMRRS GPEEKKLYTT TTVVQPLLPP ---------- ---------- ------PPL- ---DILLIIS LDRRFFLFSS SWLLHGIIYY EEF------- AALA-GLPPF RRRAAFDDTS SSPYMPPKKI TGEEEEFYVV VTLLGVGGDD IIVGMFRRRR AALVLAAPPA GGGVVRDDTS SSPYMKKKKI TGEEDDYYVV VTLLGAGGDD RAADDDDFFF IIIAVVDNPK SSSSIVVHKV VEYYDELHHF FGWNNNASAL PNGGKKIEER APPDDDDFFF LLLAVVDDPK SSSGVIIYKL LDYYDELHHF FGWNNNASAY PNAAKKLEER RPPDDDDAAA LLLAVIDKPG SSSGIVVHTV VTNNDEFHHF FGWNNNASSL PLTTHHLEER KPPDDDDAAA LLLAVIDKPG SSSGIVVHTV VTNNDEFHHF FGWNNNASAL PLAAHHIEER KPPDDDDGGG LLLAVVDDPT SSSGIVVHQL LINNDEFHHF FGWNNNASAL PLTTHHLEER QPPDDDDAAA IIIAVVDDPA SSSAIVVGQV VAHHDELHHF FGWNNNASCL PNAAHHMEER KPPDDDDAAA MMMCVVDDSQ SSSGVVVGVT TDYYGELHHF FGWNNNASML PNAAHHVEER RPPDDDDAAA LLLGVLDDPD SSSAIVVGRV VENNDELHHF FGWNNNAAAL PYAAHHVEER APPDDDDYYY LLLATVDDPK SSSSVIIHRL LPYYDELHHS SGWNNNTSC- --FFDDKSSR APPDDDDYYY LLLATVDDPK SSSSVIIHRL LPHHDELHHS SGWNNNTSC- --FFDDKSSR APPDDDDYYY LLLATVDDPK SSSCVIIHRL LPNNDELHHS SGWNNNASC- --FFDDKSSR APPDDDDYYY LLLATVDDPK SSSCVIIHRL LPHHDELHHS SGWNNNTSC- --YYDDKAAR APPDDDDYYY LLLATVDDPK SSSCVIIHRL LPNNDELHHS SGWNNNTSC- --FFDDKSSR APPDDDDYYY LLLATVDDPK SSSCVIIE-- ---------- ---------- ---------- APPDDDDYYY LLLATVDDPK SSSCVIIHRL LPNNDELHHS SGWNNNTSC- --FFDDKSSR APPDDDDYYY LLLATVDDPK SSSCVIIHRL LPNNDELHHS SGWNNNTSC- --FFDDKSSR APPDDDDYYY LLLATVDDPK SSSSVIIHRL LPYYDELHHS SGWNNNTSC- --FFDDKSSR APPDDDDYYY LLLATVDDPK SSSCVIIHRL LPNNDELHHS SGWNNNTSC- --FFDDKSSR APPDDDDYYY LLLATVDDPK SSSCVIIHRL LPNNDELHHS SGWNNNTSC- --FFDDKSSR KLLDDDDYYY LLLATVDDPS SSSSVIIHRL LPHHDKLHHS SGWNNNSSC- --HHDDAKKR ---------- ---------- ---------- --NNDELHHS SGWNNNTSC- --YYDDKVVR KPPDDDDYYY LLLATVDDPK SSSSVIIHRL LPNNDELHHS SGWNNNTSC- --YYDDKVVR KPPDDDDYYY LLLATVDDPS SSSSVIIHRL LPYYDELHHT TGWNNNSSC- --HHDDAEER KPPDDDDYYY LLLATVDDPN SSSSVIIHRL LPYYDELHHT TGWNNNSSC- --HHDDAQQR ---------- ---------- ---------- --FFDELHHS SGWNNNSSC- --HHDDADDR KPPDDDDYYY LLLATVDDPS SSSSVIIHRL LPFFDELHHS SGWNNNSSC- --HHDDVDDR KPPDDDDYYY LLLGTVDDPN SSSSVIIHRL LPHHDELHHS SGWNNNASC- --HHDDASSR GPPDDDDAAA IIIFTVDNPE SSSCVIISRV VDHHDEVHHT TGWNNNASC- --HHKKEKKR GPPDDDDAAA IIIFTVNNPE SSSCIIISRV VDNNDEVHHT TGWNNNASC- --HHKKEKKR ---------- ---------- ---------- ---------- ---------- ---------- HGGDDDDYYY LLLATVDDPA SSSCVIIHRT TYSSNELHHS SGWNNNTSCH P-GGKKPTTR HGGDDDDYYY LLLSTVDDPE SSSCIVVHRT TFRRDELHHS SGWNNNASCY DESSKKPKKR DIITTTTDDD RRRKNPRVGQ VVVGVLLKDG GPVVDKELDS SQPTTTPLK- ----KKQGGG EQQDDDDKKK LLLVTIDRPG SSSGVIINSV VSGGNEAHHG GGFSSSA--- -------DDR EQQDDDDKKK LLLVTVDNPK SSSGVVVNTL LSGGNEAHHS SDFTTTD--- -------DDR RIVPRRRRRS RRIIIDTTTN RRRKIIIKPE EEEEVKKVVG YSSRRTVHDA IYLLLLLGG- RIVPRRRRRS RRIIVDTTTD RRRAVVAKPE EEVVAGGRRG YTTKKTVHDA IYLLLLLGG- RIIPRRRRRS RRIIIDTTTH TTTRIIHKPD DDEEIAAKKG YSSRRTVHEG IYLLLLLGGG RIIPRRRRRS RRIIIDTTTD TTTKIIHKPE EEEEVKKKKG YSSRRTIHDG IYLLLLLGGG RIIPRRRRRS RRIIVDVVVE LLLKIIHKPE EEEEVAAKKG YSSRRTIHEG IYLLLLLGGG RVVPRRRRRS RRIILDTTTD LLLFLLAKPE EETTLEERRG YSSRRTVHGG IYLLLLLGG- RVVPRRRRRS HHIILDTTTD TTTKVVVKPN NNEELEERRG YAARRTVHDG IYLLLLLGG- RIVPRRRRRS RRIIVDTTTD RRRRIIVKPE EEEELRRRRG YSSRRTIHDG VYLLLLLGG- NILPMMMMMS RRIIVDVVVE RRRKLLHKAS SSEEIAAKKN VSSNNTSHSG EVTTTTTLL- DILPIIIIIS RRIIVDVVVE RRRKLLHKPN NNEEIAAKKN LGGNNTSHSG EVSSSSSLL- TMLPMMMMMS RRIIVDVVVD RRRKLLHKAE EEDDIAAKKG LGGYYTSHSG EVTTTTTLL- TVLPIIIIIS RRIIVDVVVE RRRKLLHKPK KKDDITTKKN LGGFFTSHSG EVTTTTTLL- TVLPIIIIIS RRIIVDVVVE RRRKLLHKPE EEDDIAAKKE LAAFFTSHSG EVSSSSSLL- ---------- ---------- --------PK KKDDIAAKKE LAAFFTSHSG EVSSSSSLL- TVLPIIIIIS RRIIVDVVVE RRRKLLHKPK KKDDIAAKKE LAAFFTSHSG EVSSSSSLL- TVLPIIIIIS RRIIVDVVVE RRRKLLHKPK KKDDIAAKKE LAAFFTSHSG EVSSSSSLL- NVLPIIIIIS RRIIVDVVVE RRRKLLHKAK KKDDIEEKKG LGGTTTSHTG EVTTTTTLL- TVLP------ ---------- ---------- ---------- ---------- ---------- TVLPIIIIIS RRIIVDVVVE RRRKLLHKPK KKDDIAAKKE LAAFFTSHSG EVSSSSSLL- RILPLLLLLS RRVVVDTTTD RRRSLLHKSE EEDDIEENNG LGGFFTSHSG DICCCCCLL- NILPIIIIIS RRIIVDVVVD RRRRIIHKPY YYEEVWWKKG LAANNTSHCG EISSSSSII- NILPIIIIIS RRIIVDVVVD RRRRIIHKPY YYEEVWWKKG LAANNTSHCG EISSSSSLL- RIAPVVVVVS RRIIIDTTTN RRRSLLHKPA AADDIQQKKG LAAYYTSHSG ELCCCCCLL- RIVPVVVVVS RRVVIDTTTN RRRSLLHKPE EEDDITTKKG LAAYYTSHSG EICCCCCII- RVLPIIIIIS RRIIIDTTTN RRRSLLYKPK KKEEIEEKKG LAAYYTAHSG EICCCCCLL- RVLPIIIIIS RRIIIDTTTN RRRSLLYKPK KKEEIDDKKG LAAFFTAH-G EICCCCCLL- RILPLLLLLS RRVVVDTTTD RRRALLHKAE EEDDIEEKKG LGGFFTSHSG EICCCCCLL- SIVPNNNNNS RRIIINVVVE RRRYLLEHPS SSKKLSSLL- LSSFFTSHDG NITTTTTLL- SIVPNNNNNS RRIIINVVVE RRRYLLQHPS SSKKLAALL- LSSFFTSHDG NITTTTTLL- -VPRSSSSSS VVEEVFVVV- ---------- ---------- ---------- ---------- DVLPNNNNNS RRIIIDTTTD RRRKLLAKG- --DDVKKGGD CTTAATTHNG NIIIIIIMM- DVLPNNNNNS FFIILDVVVD RRREIIVKG- --DDVKKSSN VTTAATTHNG NIVVVVVMM- PLQLDDDDDG RRLLTTSSSS WWWQFFYP-- --DDLKKFFV LAAIITADNT ALGGGGGVV- RWTGDDDDDT RRIIFDVVVD SSSKLLHKT- --FFVDDSSG VVVGGTFFGS MMLLLLLSS- RWAGDDDDDT KKIIFDVVVD AAAVLLSKD- --FFVKKSSG VVVGGTLYGR MLLLLLLSS- EGEEGGGILL LLDDHSFLLG KWIDGQYY-- --------LY DDWWNL--PP NEEVVVSSSS DGEEGGGIFF LLDDHTFIIG RWVYGQYY-- --------FY DDWWNL--PP SGGVVITSSS DGDDGPPIFF MMDDCTFLLG RWIDGQDD-- --------KY DDWWNL--PP RDDYYVSSSS DGNNGPPVFF MMDDCTFLLG RWIDGQTT-- --------LY DDWWNL--PP RDDYYVTSSS DGDDGPPIFF LLDDCTFLLG RYMDGQTT-- --------KY DDWWNL--PP RDDYYVSSSS EGKKGGGIAA LLDDASFLLG RWVEGQYY-- --------FY DDWWHL--GG YDDTTVTSSS EGEEGGGIFF LLDDHNLLLG RWIDGQYY-- --------LY DDWWHL--GG YDDTTLTSSS EGDDGGGVFF MMDDHSFLLG RWVEGQQQ-- --------LY DDWWHL--GG YDDTTVTSSS LQNNGGGFVV LLDDGTFKKG TWKPGSPP-- --------MY DDWYQP--RR HNNVVVSTTT PQNNGGGFVV LLDDGTFKKG TWKPGAPP-- --------MY DDWYQP--RR HNNIIVSTTT SKNNGGGFVV LLDDGTFKKG TWQPGAPP-- --------MY DDWYQP--RR HNNVVISTTT PENNGGGFVV LLDDGTFKKG TWQPGAPP-- --------LY DDWYQP--RR HNNVVISTTT VKNNGGGFVV LLDDGTFKKG TWRPGAPP-- --------SY DDWYQP--RR HNNVVISTTT VKNNGGGFVV LLDDGTFKKG TWRPGAPP-- --------LY DDWYQP--RR HNNVVISTTT VKNNGGGFVV LLDDGTFKKG TWRPGAPP-- --------LY DDWYQP--RR HNNVVISTTT VKNNGGGFVV LLDDGTFKKG TWRPGAPP-- --------LY DDWYQP--RR HNNVVISTTT PKNNGGGFVV LLDDGTFKKG TWRPGAPP-- --------MY DDWYQP--RR HNNVVISTTT ---------- ---------- ---------- ---------- ---------- ---------- VKNNGDDSLL LLLLPRLSSG ---------- ---------- ---------- -------AAA KENNAGGGFF LLLLDEFKKG RGNRFISS-- --------KR TTLYENYYAA WGGLLWSWWW PYNNGGGFVV LLDDGTFKKG NWAEEAPP-- --------FY DDWYQP--RR HNNVVISTTT PCNNGGGFVV LLDDGTFKKG NWVEEAQQ-- --------FY DDWYQP--RR HNNVVISTTT KDNNAGGGFF LLLLDDFKKG RWKPHPLL-- --------FY DDWYQP--RR HNNTTISTTT KDNNAGGGFF LLLLDEFKKG RWKPHPLL-- --------FY DDWYQP--RR HNNTTISTTT EENNAGGGFF LLLLDDFKKN RWKPHPLL-- --------FY DDWYQP--RR HKKTTISTTT EENNAGGGLL LLLLDDFKKN RWKPIPLL-- --------YY HHWYQP--RR HKKTTISTTT KENNAGGGFF LLLLDEFKKG RWKPHPLL-- --------FY DDWYQP--RR HKKTTISSSS ANTTPGGFLL LLDDGTFKKG TWADKVPP-- --------FY DDWYQP--RR RNNVVISTTT ADSSPGGFLL LLDDGTFKKG TWADKVPP-- --------FY DDWYQP--RR RNNIIISTTT ---------- ---------- ---------- ---------- ---------- ------SIII AENNAGGDFF EEFFDNFVVG TWRGRALL-- --------CY DDWYQP--HH FNNVVVASSS AEYYAGGDFF LLFFDDFIIG TWKGKALL-- --------CY DDWYQP--YY FDDVVVSSSS SLVVPLLGII TTSSKENSSA KGASFEII-- --------LL SSHNNG---- REEKKESDDD DDGGGTTLVV YYNNDGEAAT YWPTDMQQVV AAVVDDVDYY DDRALI--RR KNNVVLTSSS KDGGGTTLVV YYTTNGEAAT HWPTGLRRII KKTT--YDYY DDRALP--RR KNNLLVTSSS EA-TTTIELK LEKK-RRRRR RRRIIHFWWW LRKRRRKRRS LTTGEENNNR MMALL----- ET-CCCFEFS LEKKGAAAKK KKKLLHVWWW LAKRRRRHHA IDDGQEHHHR MMVLL----- EA-QQQFEIV PELLNKKKRR RRRLLHFWWW LRARRRRNNT IDDGAQHHHQ MMALL----- EA-QQQFEIV PELLNKKKRR RRRLLHFWWW LRARRRRNNT IDDGANHHHQ MMALL----- EG-QQQFEIV PELLNKKKKK KKKIIHFWWW LRDRRRKNNT IDDGANHHHQ MMALL----- EG-MMMVELV PDLLARRRRR RRRLLHFWWW LTRRRRRHHE IDDGDEHHHQ LLVFF----- EG-MMMVEVL GDLLGKKKRR RRRLLHVWWW LYRRRRRHHT LDDGAEYYYQ MMALL----- EG-MMMIELD PQLLKGGGRR RRRLLHIWWW LRRRRRRHHA LDDGEEHHHQ MMVLL----- EA-VVVFKNP AHAAGLLLRR RRRIIFVWWW WQRHHHEIIT LQQT--DDDG LLIPP----L EA-VVVFKNP AHAAGLLLHH HHHIIHVWWW WQRHHHEIIT LQQK--DDDG LLIPP----L EA-VVVFRNP ADAAGLLLHH HHHLLHVWWW WQRHHHEIIT LTTQ--DDDG LLIPP----L EA-VVVLRNP ADAAGLLLHH HHHLLYVWWW WQRRRREIIT LPPQ--DDDG LLIPP----L EA-VVVLRNP ADAAGLLLHH HHHLLYVWWW WQHHHHEIIT LSSK--DDDG LLIPP----L EA-VVVLRNP ADAAGLLLHH HHHLLYVWWW WQRHHHEIIT LSSK--DDDG LLIPP----L EA-VVVLRNP ADAAGLLLHH HHHLLYVWWW WQRHHHEIIT LSSK--DDDG LLIPP----L EA-VVVLRNP ADAAGLLLHH HHHLLYVWWW WQRHHHEIIT LSSK--DDDG LLIPP----L EA-VVVVQNP ADAAGLLLHH HHHLLHVWWW WQRHHHEIIT LLLP--DDDG HHIPP----L ---------- ---------- ---------- ---------- ---------- ---------- IA-LLLRLRD YPAASRRRII IIITT----- ---------- ---------- ---------- IC-FFFYTEL MCAASGGGII IIISSCLDDD YIMRRRVIIS LPPQ--DDDQ AAGAANNPPL EG-AAAFAKM EEAAGMMMSS SSSLLNVWWW WTEHHHRRRT IDDGE-DDDG LLIPP----L EG-AAAFAKM EDAAGHHHSS SSSLLNVWWW WTEHHHRLLT IDDGK-DDDG LLIPP----L SG-AAAFTDL QHDDGLLLHH HHHLLTCIII LARGGGELLT LDDGN-TTTG LLLPP----L SG-AAAFLNL QHDDGLLLHH HHHLLHVYYY WPGGGGEIIT LDDGD-KKKG LLLPP----L SG-AAAFSDL QHDDGLLLHH HHHLLHVYYY WPGGGGEMML IDDGE-TTTG LLLPP----L SG-AAAFSNL QHDDGLLLHH HHHLLHVYYY WPGGGGEIIL IDDGP-TTTG LLLPP----L SG-AAAFRDL QHDDGLLLHH HHHLLHVYYY WPGGGGELLT LDDGS-TTTG LLLPP----L EG-HHHIKNP AHEEGLLLSS SSSVVHIFFF WDSKKKKYYT IDDPQPLLLG AALPP----L EG-HHHIKNP AHEEGLLLSS SSSVVHIFFF WDTKKKKHHT IDDPMPRRRG AALPP----L LG-TTTVCEL KCEEPLLLCC CCCKKRVYYY ---------- ---------- ---------- EG-LLLFRHP TDDDTQQQRR RRRLLNFYYY WQERRRELLT IDDGD-DDDG LLTPP----L EG-KKKWRKN VDDDSQQQRR RRRLLNFYYY WSTQQQTLLT IDDGS-DDDG IITPP----L RD-MMMAFES FLTTPLLLHH HHHVVAEVVV ---------- ---------- ---------- STNMMMMDML QDAAKRRRTT TTTIIVQWWW LHTRRRQPPV FNNPGAPPP- ---------L STNMMMMDML ADAAKHHHTT TTTVVVTWWW LHTKKKQPPV FDDPGAPPP- ---------L -EELLPHHDK LMNNVVVSKD LLWLF-EEEK NNAAVEEIAP PG-EIIIFFF APPLTTTIII -EEVVPHHDK LMNNVLLNKD LLWLF-EEEK QQAAVDDIAP PG-PVVVFFF MPPLTTTIII -EEVVPHHDR EYGGVVVDTN LLWTW-EEEK HHVVTTTIAP PADPLLLFFF APPLTTTILL -EEVVPHHDR EYGGVVVDTN LLWTW-EEEK HHAATTTIPP PKEPLLLFFF APPLTTTILL -EEIIPHHDK DYGGVVVDTN LLFTWKDDDT EEAATTTIPP PADDLLLFFF APPLTTTILL -EELLPHHDK AYNNVIISKD LLWTY-DDDK AAVVVEEIAA APDPVVVFFF APPLTTTILL -EELLPHHDK AYNNVVVSKD LLWLY-DDDS HHLLVDDIAP PEDPIIIFFF APPLTTTILL -EELLPHHDR TYGGVVVSED LLWLH-QQQS GGIIVEEIAP PPDPLLLFFF APPLTTTILL LEEIIFHHDA TQGGALLSNI QQNEG----- -----WWSEV VVPVKKKLLL EPPLTTTILL LEEIIFHHDA TQGGALLSNI QQNEG----- -----WWSEV VVPVKKKLLL EPPLTTTILL LEEIIFHHNA AQGGALLSTI QQNQG----- -----WWSEV VVPVKKKLLL EPPLTTTILL LEEIIFHHNA AQGGALLSTI QQNEG----- -----WWSQV VVPVKKKLLL EPPLTTTILL LEEIIFHHNA AQGGALLSTI QQNEG----- -----WWSEV VVPVKKKLLL EPPLTTTILL LEEIIFHHNA AQGGALLSTI QQNEG----- -----WWSEV VVPVKKKLLL EPPLTTTILL LEEIIFHHNA AQGGALLSTI QQNEG----- -----WWSEV VVPVKKKLLL EPPLTTT--- LEEIIFHHNA AQGGALLSTI QQNEG----- -----WWSEV VVPVKKKLLL EPPLTTTILL LEEIIFHHDA SQGGALLSTI QQNEG----- -----WWSEV VVPVKKKLLL EPPLTTTILL ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LCCLLSHHWI NQVVEVVSSG RRPDY----- -----VVVKK KLYVAAAVVV SSSEPPPAII LEEIIFHHDA AQGGALLSTV FFEKG----- -----WWAEV VVPVEEELLL EPPLTTTIII LEEIIFHHNA DQGGALLSSI FFEKG----- -----WWAEV VVPVEEEMMM EPPLTTTIII LEEIIFHHDK DTGGALLSNM IITQG----- -----WWSEA AVKVQQQLLL EPPLTTTFII LEEIIFHHDK DTGGALLTNM IITQG----- -----WWNEV VVEVQQQLLL EPPLTTTFII LEEIIFHHDK DTGGALLSNM IINSD----- -----WWSEV VVKVEEELLL EPPLTTTFII LEEIIFHHDK DTGGALLSNM IINSE----- -----WWSEV VVKVEEELLL EPPLTTTFII LEEVVFHHDK DTGGALLTNM VVTAG----- -----WWSEA AIKVRRRLLL EPPLTTTFII LEEVVFHHES EHGGALLGGI FFVEN----- -----HHATV VIPVSSSLLL EPPLTTTIII LEEVVFHHES EHGGALLGAI FFDEN----- -----QQTSV VIPVEEELLL DPPLTTTIII ---------- ---------- ---------- ---------- ---------- ---------- LEEIIFHHNE NQGGAFFXXX XX-------- ---------- ---GEEEIII MGGMTTTIII LEEIIFHHNK AEGGALLNKV FFKSS----- ----FAAKVD DGKTGGGAAA DGGMSSSIII ---------- ---------- ---------- ---------- ---------- ---------- LEEIIFWWGA NYTTALLTQL WWDDG----- ---------- -WQVAAANNN AIILVVVIII LEEIICWWGH NYSSALLTQL WWDGG----- ---------- -WQVAAAEEE AVVLVVVIII LDDDDKLLYS WGGIGEEEVR RRQYDDINPF FPVVLGVLGG IHHRDHPP-- ---------- LDDDDRLLYS WGGLGEEELR RRQYDDINPH HPRRLGVIGG LHHRPHPP-- ---------- LDDDDRLLYS WGGTGEEEMR RRQYDDVDPH HPVVLGVIGG IRRRPHPP-- ---------- MDDDDRLLYS WGGTGEEEMR RRQYDDVDPR RPKKLGVIGG IRRRPHPP-- ---------- LDDDDKLLYA WGGLGEEEMH HHQYDDVDPM MPVVLGVIGG IKKKPHPP-- ---------- MDDDDRLLYS WGGTGDDDLL LLQYDDVDPF FPKKLGVIGG ISSRTHPP-- ---------- VDDDDRLLYS WGGTGEEELH HHQYDDVDPF FPRRLGVIGG IRRRGHPP-- ---------- LDDDDRLLYS WGGTGEEELR RRQYDDVDPF FPRRHGVLGG IRRKAHPP-- ---------- LDDDDRLLYS WLLHGDDDIR RRQYDDINPQ QPRRLGILGG SVVRGSVVVL LLEE-DDQQE LDDDDRLLYS WLLHGDDDIR RRQYDDINPK KPRRLGILGG SVVKGSVVVL LLEE-DDQQE LDDDDRLLYS WLLHGDDDLR RRQYDDIDPQ QPRRLGLLGG SVVKGPVVVL LLEE-DDQQE LDDDDHLLYS WLLHGDDDIR RRQYDDVDPQ QPRRLGLLGG SVVKGPVVVL LLDD-DDQQE LDDDDRLLYS WLLHGDDDLR RRQYDDIDPQ QPRRLGLLGG SVVKGPVVVL LLEE-DDQQE LDDDDRLLYS WLLHGDDDLR RRQYDDIDPQ QPRRL----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LDDDDRLLYS WLLHGDDDLR RRQYDDIDPQ QPRRLGLLGG SVVKGPVVVL LLEE-DDEEE LDDDDRLLYN WLLHGDDDMR RRQYDDIDPK KPRRLGILGG SVVKGPVVVL LLEE-DDQQE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- FSDDDLIIIL ---------- ---------- ---------- ---------- ---------- LDDDDRLLYS WLLHGDDDIR RRQYDDIDPR RPKKLGILGG SLLRGPVVVL LLEE-DDKKD LDDDDRLLYS WLLHGDDDIR RRQYDDIDTR RPKKLGILGG SQQRGPVVVL LLEE-DDKKE LDDDDRLLYV WLLHGDDDIR RRQYNNIDLK KPVVLGLVGG LQQKSPVVAI IIGG-EEDDG LDDDDRLLYV WLLHGDDDIR RRQYNNIDVK KPKKLGVAGG LQQKSPVVAV VVKK-DDDDG LDDDDRLLYV WLLHGDDDIR RRQYNNIDPK KPVVLGIVGG LQQKSPVVAV VVGG-EEDDG LDDDDRIIYV WLLHGDDDIR RRQYNNIDPK KPVVLGIVGG LQQKSPVVAV VVGG-EEDDG LDDDDRLLYV WLLHGDDDIR RRQYNNIDPA APVVLGVAGG LQQKSEVVYV VVTT-EEDDD MDDDDRLLYS WLLHGDDDIR RRQYDDIDPL LVKKLSVIGG SHHTSNVVVL LLEE-GGEEK MDDDDRLLYS WLLHGDDDIR RRQYDDIDPK KPKKLSVIGG SHHSTTVVVL LLEE-EEDDH ---------- ---------- ---------- ---------- ---------- ---------- LDDDDRLLYS WRRHGDDDVR RRQYDDIDRA APRRLGVLGG AQQRAPRRVL LLNN-DDPPE LDDDDRLLYN WRRHGDDDVR RRQYDDIDPE EPKKLGLLGG ACCSLPNNIV VVKKEDDKKE ---------- ---------- ---------- ---------- ---------- ---------- ADDDDQLLWN FMMDGKKKTR RRLFDDIDPH HPFFQYKIDD QNN------- ---------- NDDDDSLLWN FMMDGKKKTR RRLFDDIDPH HPRRQYKIGG QNN------- ---------- ---------- -----GGKGG AAAAPPPQQL EEEIISSSGV YYNNNSSYSS STTDDNFFPE ---------- -----GGEGG AAAAPPPQQI SSSVVSSSGV YYNNNSSYSS SSSNNNFFP- ---------- -----GGTGG GGGGPPPQQV EEEIISSSGV YYNNNSSYSS STTDDDFFPD ---------- -----GGAAA GGGGPPPQQV EEEIISSSGV YYNNNSSYSS STTDDDFFPD ---------- -----GGTYY GGGGPPPQQV EEEIISSSGV YYNNNSSYSS STTDDEFFPG ---------- -----NNAGG GGGGPPPQQV EEEIISSSGV YYNNNSSYGG GAADDPFFPE ---------- -----SSEGG GGGGPPPQQV EEEIISSSGV YYNNNSSYRR RAADDEFFPD ---------- -----SSPGG GGGGPPPQQV EEEVVSSSGV YYNNNSSYAA ASSDDEFFPV ELCCQPPPEE PLLVVGGRGG GGGGPPPQQI QQQLLSSSGL YYTTTSSYSS SDDDDKFF-P ELCCQPPPEE PLLVVGGRGG GGGGPPPQQI QQQLLSSSGL YYTTTSSYSS SAADDKFF-P ELSSQPPPEE PLLVVGGKGG GGGGPPPQQI QQQLLSSSGL YYTTTSSYSS SAADDKFF-P ELSSQPPPEE PLLVVGGQGG GGGGPPPQQI QQQLLSSSGL YYTTTSSYSS SAADDKFF-P ELSSQPPPEE PLLVVGGRGG GGGGPPPQQI QQQLLSSSGL YYTTTSSYSS SAADDKFF-P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ELSSQPPPEE PLLVVGGRGG GGGGPPPQQI QQQLLSSSGL YYTTTSSYSS SAADDKFF-P ELSSQPPPEE PLLVVGGRGG GGGGPPPQQI QQQLLSSSGI YYTTTSSYSS SDDDDKFF-P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DLCCQPPPDD PVVIIGGKGG GGGGPPPQQI QQQLLSSSGL YYNNNSSYSS SKKDDKFF-P ELCCQPPPDD PVVTTGGIGG GGGGPPPQQI QQQLLSSSGI YYSSSSSYSS SIIDDKFF-P GKWWQSSSDD VPPEEGGKGG GGGGPPPQQI QQQLLTTTGL YYNNNSSFSS SAADDKFF-P GEWWQSSSDD VPPEEGGKGG GGGGPPPQQI QQQLLSSSGL YYNNNSSFSS SAADDKFF-P GNFFQFFFDD VPPQQGGSGG GGGGPPPQQI QQQLLSSSGL YYNNNSSFSS SAADDRFF-P GNFFQFFFEE VPPQQGGSGG GGGGPPPQQI QQQLLSSSGL YYNNNSSFSS SAAVVVFF-P DKEEQYYYSS VPPQQGGRGG GGGGPPPQQI QQQLLSSSGI YYNNNSSFSS SRRDDEFFGQ K---PIIIEE ALLYYGGKGG GGGGPPPQQL QQQLLSSSGL YYTTTSSYKK KKKDDDFF-P HD--EIIIPP ALLYYGGQGG GGGGPPPQQL QQQLLSSSGL YYTTTSSYKK KKKDDDFF-P ---------- --------GG GGGGPPPAAI QQQLLSSSGL YYNNNSSYSS STTDDKFF-P ELEEAPPPEE PVVFFGGRGG GGGGPPPQQL QQQLLSSSGL YYSSSSSFSS SPPDDKFF-P ELEERPPPPP ARRYYGGRGG GGGGPPPQQL QQQLLSSSGL YYSSSSSYSS SPPDDKFF-P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------V SSSQQSSSGV YYSSSSSLAA ANNDD----- ---------- ---------- ---------V SSSSSSSSGL YYSSSSSLAA ANNDD----- EKGWVNN--- --PSSGEIDD KKEEFDDFFG -----ASSHL LLSSGGDDDS YPP------- -RGWANN--- --PEEGELEE KKEEFDDFFG -----AAAHL LLWWGGDDDS YPP------- DPAAVGG--- --PDDGTLAA DDDDYEEFFP GG---YAAHL LLEEGGDDDS YPPSSVVVKK DPGVVGG--- --GNNGELDD KKDDYSSFFP GG---YAAHL LLEEGGDDDS YPPSSVVV-- GGAAVGG--- --ENNGTLDD KKDDFDDFFP GG---YSSHL LLEEGGDDDS YPPSSVVV-- EDGWVGG--- --PNNGEFDD PPKKFEEWWP GG---HPPHL LLQQGGDDDS YPP------- DKGWVNN--- --PDDGQFDD PPNNFDDFFG -----QVVHL LLQQGGDDDS FPP------- VRGWADD--- --PGGGSLDD PPGGFEEVVG GG---LPPHL LLEEGGDDDS YPPSS----- PIRESVVDDD DTVNNGKLNN PPNNFDDFFG EEGGPAAAHY YYPPGGDDDI ---------- PIRESIIDDD DTANNGKLNN PPNNFDDFFG EEGGPAAAHY YYPPGGDDDI ---------- PIRESIIDDD DTVKKGKLNN PPNNFDDFFG EEGGPAAAHY YYPPGGDDDI ---------- PIRESIIDDD DTVKKGTLNN PPNNFDDFFG EEGGPAAAHY YYPPGGDDDI ---------- PIRESVVDDD DTVKKGKLNN PPNNFDDFFG EEGGPAAAHY YYPPGGDDDI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PIRESVVDDD DTVKKGKLNN PPNNFDDFFG EEGGPAAAHY YYPPGGDDDI ---------- PIRESIIDDD DTVKKGKLNN PPNNFDDFFG EEGGPAAAHY YYPPGGDDDI ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- PIKESIIDDD DTEKKGKLNN PPNNFDDFFG EEGGPVAAHY YYPPGGDDDI ---------- PLKEAIIDDD DTKKKGKLNN PPNNFDDFFG EEGGPVAAHY YYPPGGDDDI ---------- PVEKSIIDDD DTEKKGKINN PPNNFDDFFG EEGGPAAAHY YYPPGGDDDI ---------- PVEQSIIDDD DTENNGKINN PPNNFDDFFG EEGGPSAAHY YYPPGGDDDI ---------- PMDKSIIDDD DTEKKGSINN PPNNFDDFFG EEGGPAAAHY YYPPGGDDDI ---------- PMEKSIIDDD DTEKKGTINN PPDDFDDFFG EEGGPSAAHY YYPPGGDDDI ---------- QVKKSIIDDD DTEKKGSINN PPNNFDDFFG EEGGPSAAHY YYPPGGDDDI ---------- PVKSAVVNDD DPESSGEINN RRDDFDDFFG IIGGPYAAHY YYPPGGDDDI ---------- PVRSAIIDDD DPITTGVINN KKNNFDDFFG VVGGPYAAHY YYPPGGDDDI ---------- PVKESIIDDD DTEKKGTVNN KKNNFDDFFG EEGGPCAAHF FFPPCCDDDI ---------- PVAAGLLDDD DVENNGKLNN EENNFDDFFG EEGGPGPPH- ---------- ---------- PVSQGIIDDD DTVNNGSLNN EEDDFDDFFA EEGGPSPPHY YYPPGGDDDI ANNDDAAA-- ---------- ---------- ---------- ---------- ---------- ---------- --KKKYYLAA AYNWWDELVV EEDDFDDFFY LLGG--AAHF FFGGSSASS- ---------- --KKKFFLLL LYYWWDELKK EEQQFDDFFY EEGG--PPHF FFGGAAAGGP DGGNNRRRLL ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- QAVVVEE 35 667 gi|1592023---------- ---------- ---------- ---------- ---------- ---------- gi|1831354---------- ---------- ---------- ---------- ---------- ---------- gi|1248721---------- ---------- ---------- ---------- ---------- ---------- gi|2738306---------- ---------- ---------- ---------- ---------- ---------- gi|5669652---------- ---------- ---------- ---------- ---------- ---------- gi|7353886---------- ---------- ---------- ---------- ---------- ---------- gi|1638463---------- ---------- ---------- ---------- ---------- ---------- gi|1088031---------- ---------- ---------- ---------- ---------- ---------- gi|9507079---------- ---------- ---------- ---------- ---------- ---------- gi|1490307---------- ---------- ---------- ---------- ---------- ---------- gi|7398158MNAKKKQQPS SEECCCRTTA TLAAAALLLA DGMSLPRRTT TAAQLLLLLT TTPVVIIKKA gi|1836375---------- ---------- ---------- ---------- ---------- ---------- gi|1145594---------- ---------- ---------- ---------- ---------- ---------- gi|1504393---------- ---------- ---------- ---------- ---------- ---------- gi|1504394---------- ---------- ---------- ---------- ---------- ---------- gi|1630655---------- ---------- ---------- ---------- ---------- ---------- gi|1497514---------- ---------- ---------- ---------- ---------- ---------- gi|1504395---------- ---------- ---------- ---------- ---------- ---------- gi|1504396---------- ---------- ---------- ---------- ---------- ---------- gi|3332103---------- ---------- ---------- ---------- ---------- ---------- gi|8926735---------- ---------- ---------- ---------- ---------- ---------- gi|1482249---------- ---------- ---------- ---------- ---------- ---------- gi|1548571---------- ---------- ---------- ---------- ---------- ---------- gi|1548572---------- ---------- ---------- ---------- ---------- ---------- gi|2034023---------- ---------- ---------- ---------- ---------- ---------- gi|1548523---------- ---------- ---------- ---------- ---------- ---------- gi|1154418---------- ---------- ---------- ---------- ---------- ---------- gi|1754305---------- ---------- ---------- ---------- ---------- ---------- gi|1577549---------- ---------- ---------- ---------- ---------- ---------- gi|1181022---------- ---------- ---------- ---------- ---------- ---------- gi|1582881---------- ---------- ---------- ---------- ---------- ---------- gi|1529127---------- ---------- ---------- ---------- ---------- ---------- gi|1258402---------- ---------- ---------- ---------- ---------- ---------- gi|5670905---------- ---------- ---------- ---------- ---------- ---------- gi|5380237---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- AQQEAAAAWT FFFSSSVVSS SPRSEESSSK KGRRKRSSPG GLSAVVVVAS SQAAAAAVQQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -AAGSSSSAP TTTLLPNNPT TPHPNNPPPL LAPPAPPPPR RVLVRRRRPV VPPPPRRLPP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMAIFKK DDTPKKMMKK AAPPPLLVVL ---------- ---------- ---------- ------MLKK DDTPRRDDRR AAPPPIIVVL ---------- ---------- ---------- -------MRR DDTPEELLQQ AAPPPFFTTL ---------- ---------- ---------- -------MRR DDTPKKLLEE AAPPPFFTTL ---------- ---------- ---------- -------LRR DDTAKKLLEE GGPPPLLTTL ---------- ---------- ---------- ------MWKK DDSPRRLLKK AAPPPIIVVF ---------- ---------- ---------- ------MWRR DDTPRRMMKK AAPPPLLVVL ---------- ---------- ---------- ------MWRR DDTPKKMMQQ AAPPPLLVVL ---------- ---------- ---------- ---TTKC--- GGGLEEAA-- GGPPPIILLI ---------- ---------- ---------- ---------- ---------- GGPPPIILLI QQAAWLLPGG HHHHHHGAAA AAAAAIGGPG GG-TTQC--- GGGLEEAA-- GGPPPIILLI ---------- ---------- ---------- ---------- ---------- GGPPPIILLI ---------- ---------- ---------- ---TTKC--- GGGLEEAA-- GGPPPIILLI -------ARR EEEEEEGAFF FFFFFQPPPI IIATTKC--- GGGLEEAA-- GGPPPIILLI ---------- ---------- ---------- ---TTKC--- GGGLEEAA-- GG-------- ---------- ---------- ---------- ---TTKC--- GGGLEEAA-- GGPPPIILLI ----GLLGEE PPPPPPGHTT TTTTTPGGWQ QQETTKC--- GGGQEEAA-- GGPPPIILLI --LLNSSQCC GGGGGGFDQQ QQQQQTYYLV VVFTTKC--- GGGLEEAA-- GGPPPIILLI ---------- ---------- ---------- ---TTKC--- GGGLEEAA-- GGPPPIILLI PPPPHAARSS VVVVVVLQHH HHHHHEVVAA AAAKKTCTAA GGGLEEAAKK GGPPPLLVVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---AAKC--- GGGLDDAA-- GGPPPIILLI ---------- ---------- -----AHHVN NNE--VNCKK GGGIEESS-- GGPPPLLVVV ---------- ---------- -----GHHVS SSENNQQCKK GGGLEEAA-- GGPPPLLVVV ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ------RQVV GGGLAAAA-- GGPPPLLVVV ---------- ---------- --------AA AAAAAACGAA GGGLEEAAKK GGPPPLLVVV ---------- ---------- --------MS SSPLLKC--- GGGADDAA-- GGPPPVVVVP ---------- ---------- --------MP PP-LLKC--- GGGADDAA-- GGPPPVVVVP ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---MMSECKK GGGLDDAANN GGPPPLLVVV ---------- ---------- ---------- ---------- --------SS GGPPPLLTTV ---------- ---------- ---------- ---------- MMG-DDIISS LLDDDLLSSL -----MMKRR FFFFFFG--- ------AAAG GG-MMGLRAA AAEPYYMMII TTGGGFFVVL -----MMKFF VVVVVVSGPP PPPPPHAASG GGLLLAAGVV AAEPYYMMII TTGGGYYVVL TTGGNNRRDD FIVDDDPKKE YYSVHHKEEL YINLHHHGGW NAASALLCC- --NNN-KRRF VVGGNNAADD FLVDDDPKKP YYGIYYKDDL YIGLHHHGGW NAASAYYCC- --NNN-KRRY PPSS--RRDD ALIDDDPGGS YYGVHHTTTM NTGFHHHGGW NAASSLLSS- --LLLGHRRF PPSS--KKDD ALIDDDPGGP YYGVHHTTTM NKGFHHHGGW NAASALLSS- --LLLGHRRY PPSS--KKDD GLVDDDPTTE FFGVHHQIIM NKGFHHHGGW NAASALLSS- --LLLGHRRY PPKK--QQDD AIVDDDPAAP YYAVGGQAAM HAGLHHHGGW NAASCLLCC- --NNNPHRRY PPNN--KKDD AMVDDDSQQS FFGVGGVDDM YTGLHHHGGW NAASMLLCC- --NNNPHRRY PPEE--RRDD ALLDDDPDDG YYAVGGREEM NAALHHHGGW NAAAALLCC- --YYYPHRRY RRGGEEAADD YLVDDDPKKP YYSIHHRPPM YLKLHHHGGW NTTSC----- -----GDRNK RRGGEEAADD YLVDDDPKKP YYSIHHRPPM HLKLHHHGGW NTTSC----- -----GDRDK GGGGEEAADD YLVDDDPKKP YYCIHHRPPM NLRLHHHGGW NAASC----- -----GDRTK RRGGEEAADD YLVDDDPKKP YYCIHHRPPM HLKLHHHGGW NTTSC----- -----GDRTK RRGGEEAADD YLVDDDPKKP YYCIHHRPPM NLKLHHHGGW NTTSC----- -----GDRTK RRGGEEAADD YLVDDDPKKP YYCIEE---- ---------- ---------- ---------- ----EEAADD YLVDDDPKKP YYCIHHRPPM NLKLHHHGGW NTTSC----- -----GDRTK RRGGEEAADD YLVDDDPKKP YYCIHHRPPM NLKLHHHGGW NTTSC----- -----GDRTK RRGGEEAADD YLVDDDPKKP YYSIHHRPPM YLKLHHHGGW NTTSC----- -----GDRNK RRGGEEAADD YLVDDDPKKP YYCIHHRPPM NLKLHHHGGW NTTSC----- -----GDRTK RRGGEEAADD YLVDDDPKKP YYCIHHRPPM NLKLHHHGGW NTTSC----- -----GDRTK NNGGNNKKDD YLVDDDPSSP YYSIHHRPPV HIGLHHHGGW NSSSC----- -----GDRRF ---------- ---------- ---------M NTNLHHHGGW NTTSC----- -----GDRNK RRGGNNKKDD YLVDDDPKKP YYSIHHRPPM NVNLHHHGGW NTTSC----- -----GDRNK AAGGEEKKDD YLVDDDPSSP YYSIHHRPPV YVGLHHHGGW NSSSC----- -----GDRRF AAGGEEKKDD YLVDDDPNNP YYSIHHRPPV YVGLHHHGGW NSSSC----- -----GDRRF ---------- ---------- ---------M FVGLHHHGGW NSSSC----- -----GDRRY TTGGDDKKDD YLVDDDPSSP YYSIHHRPPM FVGLHHHGGW NSSSC----- -----GDRRY NNGGNNKKDD YLVDDDPNNP YYSIHHRPPV HVGLHHHGGW NAASC----- -----GDRRF --AADDGGDD AIVDDDPEED FFCISSRDDV HIGVHHHGGW NAASC----- -----DKRSH --AADDGGDD AIVNNNPEEE FFCISSRDDV NIGVHHHGGW NAASC----- -----DKRSH ---------- ---------- ---------- ---------- ---------- ---------- PPDDEEHHDD YLVDDDPAAP YYCIHHRYYT SKHLHHHGGW NTTSCHHFFV VV---GKRDR PPDDPPHHDD YLVDDDPEEP YYCVHHRFFT RKGLHHHGGW NAASCYYYYV VVEEESKRDR GGRRYYDDTT DRPRRRGQQF GGGLKKDPPV VLEELLDQQP TPPLK----- -----GKGPQ VVMMDDEEDD KLIDDDPGGA RRGINNSSSV G-RAHHHGGF SAA------- -------RRF AAVVDDEEDD KLVDDDPKKP YYGVNNTSSV G-RAHHHDDF TDD------- -------RRY FLLPRSRRYD TPREIIEEPP EEKKVVSSRR RLHTTTVCCG GDDAIYYIII AALGNN-GGG YLLPRSRRYD TKRRVVEEPP EVVVRRTTKK KYHTTTVCCG GDDAIYYIII AALGGG-GGG FLLPRSRRYD TPTQIIEEPP DELLKKTTRR RPHTTTVCCG GEEGIYYVVV TTLGGGGGGG YLLPRSRRYD TPTKIIEEPP EEFFKKTTRR RPHTTTICCG GDDGIYYVVV TTLGGGGGGG YLLPRSRRYD VPLKIIEEPP EEFFKKTTRR RPHTTTICCG GEEGIYYVVV TTLGGGGGGG YLLPRSRRYD TPLKLIEEPP ETAARRTTRR RPHTTTVCCG GGGGIYYVVV AALGNN-GGG YLLPRSHHTD TPTQVIDDPP NEAARRTTRR RPHTTTVCCG GDDGIYYIII AALGSS-GGG YLLPRSRRHD TPREIIEEPP EEHHRRTTRR RPHTTTICCG GDDGVYYVVV AALGSS-GGG KLLPMSRRYD VPRALIEEAA SEQQKKCCNN NTHTTTSCCL LSSGEVVMMM NNTLGG-QQG KLLPISRRYD VPRALIEEPP NEHHKKCCNN NLHTTTSCCL LSSGEVVMMM SSSLGG-QQG KLLPMSRRYD VPRALIEEAA EDHHKKCCYY YVHTTTSCCL LSSGEVVMMM SSTLGG-KKG KLLPISRRYD VPRALIEEPP KDHHKKCCFF FFHTTTSCCL LSSGEVVMMM SSTLGG-EEG KLLPISRRYD VPRALIEEPP EDHHKKCCFF FLHTTTSCCL LSSGEVVMMM SSSLGG-KKG ---------- --------PP KDHHKKCCFF FLHTTTSCCL LSSGEVVMMM SSSLGG-KKG KLLPISRRYD VPRALIEEPP KDHHKKCCFF FLHTTTSCCL LSSGEVVMMM SSSLGG-KKG KLLPISRRYD VPRALIEEPP KDHHKKCCFF FLHTTTSCCL LSSGEVVMMM SSSLGG-KKG KLLPISRRYD VPRALIEEAA KDHHKKCCTT TPHTTTSCCL LTTGEVVMMM SSTLGG-KKG KLLP------ ---------- ---------- ---------- ---------- ---------- KLLPISRRYD VPRALIEEPP KDHHKKCCFF FLHTTTSCCL LSSGEVVMMM SSSLGG-KKG FLLPLSRRYD TPRTLVEESS EDAANNIIFF FPHTTTSCCL LSSGDIIMMM SSCLGG-EEA KLLPISRRYD VPRAIVEEPP YEFFKKCCNN NLHTTTSCCL LCCGEIIMMM SSSIGG-YYG KLLPISRRYD VPRAIVEEPP YEFFKKCCNN NPHTTTSCCL LCCGEIIMMM SSSLGG-CCG FLLPVSRRYD TPRSLVDDPP ADIIKKTTYY YPHTTTSCCL LSSGELLMMM SSCLGG-DDA FLLPVSRRYD TPRALVEEPP EDSSKKTTYY YPHTTTSCCL LSSGEIIMMM SSCIGG-DDA YLLPISRRYD TPRALVDDPP KEAAKKTTYY YPHTTTACCL LSSGEIILLL SSCLGG-EEA YLLPISRRYD TPRALVDDPP KEAAKKTTFF FPHTTTACCR R--GEIILLL SSCLGG-EEA FLLPLSRRYD TPRALVEEAA EDAAKKTTFF FPHTTTSCCL LSSGEIIMMM SSCLGG-EEA HLLPNSRRYN V-RKLIEEPP SKHHLLNNFF FPHTTTSCCL LDDGNIIMMM SSTLGG-NNP HLLPNSRRYN V-RELIEEPP SKHHLLNNFF FPHTTTSCCL LDDGNIIMMM SSTLGG-DDP -MMRSSVVGF V--------- ---------- ---------- ---------- ---------- RLLPNSRRFD TPRALIEEGG -DLLGGAAAA APHTTTTCCL LNNGNIIMMM SSIMGG-EEA RLLPNSFFYD VPRKIIDDGG -DLLSSHHAA APHTTTTCCL LNNGNIIMMM SSVMGG-EEA QMMLDGRRYT SAWDF----- -DIIFFLLII ISHTTTAYYQ QNNTALLKKK DDGVNN-LLP FFFGDTRRFD VPSNLIDDTT -FKKSSGGGG GPHTTTFAAL LGGSMMMIII GGLSNN-DDG YLLGDTKKFD VPARLITTDD -FEESSGGGG GPHTTTLAAL LGGRMLLIII GGLSNN-DDG PPPPGLMHHH SLGGGKKEDD GGDDY----- -----YFWNN LLL-PNEVVL LVSEPNN--T PPPPGFLHHH TIGGGRREYY GGPPY----- -----YFWNN LLL-PSGVVM MISEPRR--C AAAAGFICCC TLGGGRREDD GGPPD----- -----YFWNN LLL-PRDYYM MVSEPPP--Q PPPPGFICCC TLGGGRREDD GGPPT----- -----YFWNN LLL-PRDYYM MVSEPPP--Q PPPPGFICCC TLGGGRREDD GGEET----- -----YFWNN LLL-PRDYYM MVSEPPP--Q PPPPGAMAAA SLGGGRREEE GGPPY----- -----YGWHH LLL-GYDTTL LVSEPDD--M PPPPGFIHHH NLGGGRREDD GGDDY----- -----YFWHH LLL-GYDTTL LLSEPRR--M PPPPGFVHHH SLGGGRREEE GGPPQ----- -----YFWHH LLL-GYDTTM MVSEPNN--M KKKKSVLGGG TKGGGTTEPP GGAAP----- -----YFYQQ PPP-RHNVVM MVTEPNN--V KKKKGVLGGG TKGGGTTEPP GGEEP----- -----YFYQQ PPP-RHNIIM MVTEPNN--V KKKKGVLGGG TKGGGTTEPP GGAAP----- -----YFYQQ PPP-RHNVVM MITEPNN--V KKKKGVLGGG TKGGGTTEPP GGAAP----- -----YFYQQ PPP-RHNVVM MITEPNN--V KKKKGVLGGG TKGGGTTEPP GGAAP----- -----YFYQQ PPP-RHNVVM MITEPNN--V KKKKGVLGGG TKGGGTTEPP GGAAP----- -----YFYQQ PPP-RHNVVM MITEPNN--V KKKKGVLGGG TKGGGTTEPP GGAAP----- -----YFYQQ PPP-RHNVVM MITEPNN--V KKKKGVLGGG TKGGGTTEPP GGAAP----- -----YFYQQ PPP-RHNVVM MITEPNN--V KKKKGVLGGG TKGGGTTEPP GGSSP----- -----YFYQQ PPP-RHNVVM MITEPNN--V ---------- ---------- ---------- ---------- ---------- ---------- KKKKGLVPPP RSGGG----- ---------- ---------- ---------- --AISNN--L AAAANFLDDD EKGGGRRSRR FFPPS----- -----RHYEE NNNYAWGLLF FWWISLL--F KKKKGVLGGG TKGGGNNEEE EEAAP----- -----YFYQQ PPP-RHNVVM MITEPKK--A KKKKGVLGGG TKGGGNNEEE EESSQ----- -----YFYQQ PPP-RHNVVM MITEPKK--A EEEENFLDDD DKGGGRREPP HHSSL----- -----YFYQQ PPP-RHNTTM MITSPTT--A EEEENFLDDD EKGGGRREPP HHSSL----- -----YFYQQ PPP-RHNTTM MITSPKK--A KKKKNFLDDD DKNNNRREPP HHSSL----- -----YFYQQ PPP-RHKTTM MITSPKK--A KKKKNLLDDD DKNNNRREPP IISSL----- -----YFYQQ PPP-RHKTTM MITSPKK--A AAAANFLDDD EKGGGRREPP HHSSL----- -----YYYQQ PPP-RHKTTM MISSPAA--A SSSSNLLGGG TKGGGTTPDD KKTTP----- -----YFYQQ PPP-RRNVVM MITEPNN--H SSSSNLLGGG TKGGGTTPDD KKVVP----- -----YFYQQ PPP-RRNIIM MITEPNN--H ---------- ---------- ---------- ---------- ---------- --ILPVV--T KKKK-FVDDD NVGGGTTSGG RRKKL----- -----YYYQQ PPP-HFNVVM MVSEPKK--L KKKK-FIDDD DIGGGTTTGG KKKKL----- -----YFYQQ PPP-YFDVVM MVSEPNN--K VVVVNIQKKK ESAAAKKESS FFEEI----- -----LNNNN GGG--REKKS SEDRPII--M RRRRAVEDDD GATTTYYMTT DDDDQGAAVA VVVVDYIALL III-RKNVVM MLSSWSSYYM RRRRAVENNN GATTTHHITT GGDDRGAAIK TYYYDYVALL PPP-RKNLLL LVSSWNNYYM TTTTIEEDDD LLLEELKYYG NNIIIIHFWW DDLKRRLLLG GGGENR--EE RPLDDPPTTK CCCCFEEEEE FLLEELKYYG NNLLLLHVWW DDLKRHILLG GGGEHR--EE RPLDDPPTTK QQQQFEENNN IPPEELLYYG HHLLLLHFWW DDLARNILLG GGGQHQ--EE RPADDPPVVR QQQQFEENNN IPPEELLYYG HHLLLLHFWW DDLARNILLG GGGNHQ--EE RPADDPPVVR QQQQFEENNN IPPEELLYYG HHIIIIHFWW KKLDRNILLG GGGNHQ--EE RPADDPPSSK MMMMVEEDDD LPPDDLLYYG RRLLLLHFWW DDLRRHIFFG GGGEHQ--EE RPADDPPTTK MMMMVEESSS VGGDDLLYYG HHLLLLHVWW DDLRRHLLLG GGGEYQ--EE RPADDPPTTK MMMMIEEGGG LPPQQLLYYG RRLLLLHIWW DDLRRHLVVG GGGEHQ--EE RPADDPPAAR VVVVFKKDDD NAAHHEAYYG SSIIIIFVWW DDWRHILMMT TTT-DG--EE RFLDDPPSSA VVVVFKKDDD NAAHHEAYYG SSIIIIHVWW DDWRHILMMK KKK-DG--EE RFLDDPPDDA VVVVFRRDDD NAADDEAYYG SSLLLLHVWW DDWRHILLLQ QQQ-DG--EE RFLNNPPDDA VVVVLRRDDD NAADDKAYYG SSLLLLYVWW DDWRRILLLQ QQQ-DG--EE RFLNNPPDDA VVVVLRRDDD NAADDEAYYG SSLLLLYVWW DDWHHILLLK KKK-DG--EE RFLNNPPDDA VVVVLRRDDD NAADDEAYYG SSLLLLYVWW DDWRHILLLK KKK-DG--EE RFLNNPPDDA VVVVLRRDDD NAADDEAYYG SSLLLLYVWW DDWRHILLLK KKK-DG--EE RFLNNPPDDA VVVVLRRDDD NAADDEAYYG SSLLLLYVWW DDWRHILLLK KKK-DG--EE RFLNNPPDDA VVVVVQQNNN NAADDEAYYG KKLLLLHVWW DDWRHILMMP PPP-DG--EE RFLDDPPAAA ---------- ---------- ---------- ---------- ---------- ---------- LLLLRLLTTT RYYPPSAVVA GGTTTT---- ---------- ---------- ---------- FFFFYTTTTT EMMCCTAVVH VVSSSSCLDD NNYMRILLLQ QQQ-DQNNCC RSIWWKKNNI AAAAFAALLL KEEEEQAYYG HHLLLLNVWW DDWEHRILLG GGG-DG--EE RFLDDPPDDA AAAAFAALLL KEEDDQAYYG HHLLLLNVWW DDWEHLILLG GGG-DG--EE RFLNNPPDDA AAAAFTTKKK DQQHHADYYG RRLLLLTCII QQLRGLLLLG GGG-TG--EE RFLDDPPAAK AAAAFLLQQQ NQQHHADYYG RRLLLLHVYY SSWGGILLLG GGG-KG--EE RFLDDPPAAK AAAAFSSKKK DQQHHADYYG SSLLLLHVYY SSWGGMILLG GGG-TG--EE RFLDDPPSSK AAAAFSSKKK NQQHHADYYG SSLLLLHVYY SSWGGIILLG GGG-TG--EE RFLDDPPSSK AAAAFRRTTT DQQHHQDYYG RRLLLLHVYY DDWGGLLLLG GGG-TG--EE RFLDDPPSSK HHHHIKKKKK NAAHHGEYYG NNVVVVHIFF EEWSKYILLP PPPPLG--EE RFLEEPPTTS HHHHIKKKKK NAAHHPEYYG NNVVVVHIFF EEWTKHILLP PPPPRG--EE RFLEEPPTTS TTTTVCCRRR EKKCCPEVVI KKKKKKRVYY ---------- ---------- ---------- LLLLFRRRRR HTTDDDDYYG CCLLLLNFYY RRWERLILLG GGG-DG--EE RFLNNPPRRE KKKKWRRRRR KVVDDEDYYG CCLLLLNFYY KKWTQLILLG GGG-DG--EE RFLNNPPKKK MMMMAFFEEE EFFLLKTKKP QQVVVVAEVV LL-------- ---------- ---------- MMMMMDDFFF MQQDDEAFFG NNIIIIVQWW DDLTRPFVVP PPPAP---EE RFPGGSSNNA MMMMMDDFFF MAADDEAFFG NNVVVVVTWW DDLTKPFVVP PPPAP---EE RCAGGEEAAH KMMGFIIIMV SSLKDLLSSI WLLWWDGGKK WWVIPPAAEE PPLL--PPEE LLLKKPFFAA KMMGFVVVVV NNTKDLLSSI WLLWWDGGKK WWVIEEAAQQ PPFF--PPPP LLLKKDFFMM RYYGFVVVVV DDTTNLLESI WTTWWGGGKK FFTIPPAAEE PPAADDPPPP LLLQQGFFAA RYYGFVVVVV DDTTNLLESI WTTWWGGGKK FFTIPPPPEE PPAAEEPPPP LLLQQGFFAA KYYGFCCCVV DDTTNLLQAI FTTWWDGGTT FFTIDDPPVV PPAADDPPDD LLLKKGFFAA KYYGFVVVCV SSLKDLLSSI WTTWWKDDKK WWVIPPAAEE AAAADDPPPP LLLKKGFFAA KYYGFMMMCV SSLKDLLSSI WLLWWNGGSS WWVIPPAAEE PPAADDPPPP LLLKKPFFAA RYYGFVVVVV SSLEDLLSSV WLLWWNGGSS WWVIPPAAEE PPAADDPPPP LLLKKDFFAA AQQGFVVVCA SSSNIQQRYK NEEEE----- ---SVVEEKK VVIIPPKKVV GGGWWMLLEE AQQGFVVVCA SSSNIQQRYK NEEGG----- ---SVVEEKK VVIIPPKKVV GGGWWMLLEE AQQGFVVVCA SSSTIQQRYK NQQGG----- ---SVVEEKK VVIIPPKKVV GGGWWMLLEE AQQGFVVVCA SSSTIQQRFK NEEDD----- ---SAAQQKK VVIIPPKKVV GGGWWMLLEE AQQGFVVVCA SSSTIQQRYK NEEGG----- ---SVVEEKK VVIIPPKKVV GGGWWLLLEE AQQGFVVVCA SSSTIQQRYK NEEGG----- ---SVVEEKK VVIIPPKKVV GGGWWLLLEE AQQGFVVVCA SSSTIQQRYK NEEGG----- ---SVVEEKK VVIIPPKKVV GGGWWLLLEE AQQGFVVVCA SSSTIQQRYK NEEGG----- ---SVVEEKK VVIIPPKKVV GGGWWLLLEE AQQGFVVVCA SSSTIQQRYK NEEGG----- ---SVVEEKK VVIIPPKKVV GGGWWMLLEE ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- IQQDYDDDVE SSFSGRRGSD PDDAA----- ---VLLKKRR KKLLYYVVVV KKKFFGVVSS AQQGLVVVCA SSSTVFFRYK EKKDD----- ---AAAEEKK VVIIPPKKVV GGGWWALLEE AQQGLVVVCA SSSSIFFRYK EKKDD----- ---AAAEEKK VVIIPPKKVV GGGWWPMMEE KTTGFVVVSA SSSNMIIRFK TQQDD----- ---SHHEELL AAIIKKKKVV NNNWWILLEE KTTGFVVVSA TTSNMIIRFK TQQDD----- ---NHHEEII VVIIEEKKVV NNNWWFLLEE KTTGYVVVSA SSSNMIIRFK NSSDD----- ---SYYEEII VVIIKKKKVV NNNWWILLEE KTTGFVVVSA SSSNMIIRFK NSSDD----- ---SHHEEVV VVIIKKKKVV NNNWWILLEE KTTGYVVVCA TTSNMVVRFK TAADD----- ---SHHEEVV AAIIKKKKVV NNNWWILLEE SHHAFVVVCA GGSGIFFRHP VEEEE----- ---AAATTLL VVAAPPKKVV GGGWWALLEE SHHAFVVVCA GGSAIFFRHP DEEKK----- ---TAASSLL VVAAPPKKVV NNNWWALLDD ---------- ---------- ---------- ---------- ---------- ---------- EQQGYVVVCA XXXXXXXXX- ---------- ---------- ------QQGG NNNGGEIIMM KEEGFVVVCA NNAKVFFHKK KSSDD----- --FKKKVVII DDIIKKDDTT SSSGGVAADD ---------- ---------- ---------- ---------- ---------- ---------- AYYAFSSSTA TTSQLWWLYE DDDAA----- ---------- ----QQAAVV DDDIIGNNAA HYYCFTTTTA TTSQLWWLYE DGGEE----- ---------- ----QQAAVV DDDIIGEEAA VVVPPPPPVD DDDILDFLYL WGGIIGVQYY DDIINNNPFK KKVVTTKKVK LGGGDDHHP- VVVPPPPPVD DDDILDFLYL WGGLLGLQYY DDIINNNPHQ QQRRAARRVK IGGGPPHHP- VVVPPPPPVD DDDLLDFLYC WGGTTGMQYY DDVVDDDPHN NNVVAASSVR IGGGPPHHP- VVVPPPPPVD DDDLMDFLYC WGGTTGMQYY DDVVDDDPRK KKKKAASSVH IGGGPPHHP- CCCPPPPPVD DDDLLDYLYC WGGLLGMQYY DDVVDDDPMN NNVVTTKKVE IGGGPPHHP- VVVPPPPPVD DDDLMDFLYC WGGTTGLQYY DDVVDDDPFE EEKKTTKKVR IGGGTTHHPG VVVPPPPPVD NNNLVDFLYC WGGTTGLQYY DDVVDDDPFN NNRRTTKKVQ IGGGGGHHP- VVVPPPPPVD NNNLLDFLYC WGGTTGLQYY DDVVDDDPFN NNRRTTSSVR LGGGAAHHP- MMMPPPGGID LLLLLDFLYN WLLHHGIQYY DDIINNNPQK KKRRTTQQIF LGGGGGSSVQ MMMPPPGGID LLLLLDFLYN WLLHHGIQYY DDIINNNPKK KKRRTTQQIF LGGGGGSSVQ MMMPPPGGID LLLLLDFLYN WLLHHGLQYY DDIIDDDPQR RRRRTTQQLF LGGGGGPPVQ MMMPPPGGID LLLLLDFLYN WLLHHGIQYY DDVVDDDPQR RRRRTTQQLF LGGGGGPPVQ MMMPPPGGID LLLLLDFLYN WLLHHGLQYY DDIIDDDPQR RRRRTTQQLF LGGGGGPPVQ MMMPPPGGID LLLLLDFLYN WLLHHGLQYY DDIIDDDPQR RRRR------ ---------- MMMPPPGGI- ---------- ---------- ---------- ---------- ---------- MMMPPPGGID LLLLLDFLYN WLLHHGLQYY DDIIDDDPQR RRRRTTQQLF LGGGGGPPVQ MMMPPPGGID LLLLLDFLYN WLLHHGMQYY DDIIDDDPKR RRRRVVQQIF LGGGGGPPVQ ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- LLLSSSNNFP WWWIFDLIIS ---------- ---------- ---------- ---------- MMMPPPGGID LLLILDFLYN WLLHHGIQYY DDIIDDDPRN NNKKVVQQIF LGGGGGPPVT MMMPPPGGID LLLILDFLYN WLLHHGIQYY DDIIDDDTRN NNKKVVQQIF LGGGGGPPVT MMMPPPGGID LLLILDFLYN WLLHHGIQYY NNIIDDDLKN NNVVTTQQLW VGGGSSPPVA MMMPPPGGID LLLILDFLYN WLLHHGIQYY NNIIDDDVKN NNKKTTQQVW AGGGSSPPVV MMMPPPGGID LLLILDFLYN WLLHHGIQYY NNIIDDDPKN NNVVTTQQIW VGGGSSPPVK MMMPPPGGID LLLILDFIYN WLLHHGIQYY NNIIDDDPKN NNVVTTQQIW VGGGSSPPVK MMMPPPGGID VVVILDYLYN WLLHHGIQYY NNIIDDDPAK KKVVAAQQVW AGGGSSEEVV MMMPPPAAID LLLIMDFLYC WLLHHGIQYY DDIIDDDPLK KKKKNNQQVY IGGGSSNNVK MMMPPPAAID LLLIMDFLYC WLLHHGIQYY DDIIDDDPKN NNKKNNQQVF IGGGTTTTVK ---------- ---------- ---------- ---------- ---------- ---------- MMMGGGGGMD LLLILDYLYN WRRHHGVQYY DDIIDDDRAN NNRRTTQQVF LGGGAAPPRR MMMGGGGGID IIIILDFLYC WRRHHGVQYY DDIIDDDPEN NNKKTTQQLF LGGGLLPPNV ---------- ---------- ---------- ---------- ---------- ---------- DDDIIIPPPD SSSIADTLWS FMMDDGTLFF DDIIDDDPHK KKFFIIEEKV IDRR------ KKKVVVPPPD SSSINDRLWT FMMDDGTLFF DDIIDDDPHH HHRRVVEEKT IGAA------ ---------- --------AA HLTTAPQLLE ESSSRDDGRR VYVVNSSSLY YSTDDNFYPE ---------- --------SS AATTAPQIIS SSSSRDDGRR VYIINSSSLY YSSNNNFYP- ---------- --------NN RFAAGPQVVE ESSSRDDGRR VYWWNSSSLY YSTDDDFYPD ---------- --------NN KFAAGPQVVE ESSSRDDGRR VYWWNSSSLY YSTDDDFYPD ---------- --------NN KFGGGPQVVE ESSSRDDGKK VYWWNSSSLY YSTDDEFYPG G--------- -------AKK GLNNGPQVVE ESSSRDDGRR VYFFNSSSLY YGADDPFYPE ---------- -------ATT ALNNGPQVVE ESSSRDDGRR VYFFNSSSLY YRADDEFYPD ---------- --------AA GLNNGPQVVE ESSSRDDGRR VYFFNSSSLY YASDDEFYPV QLLE---DDQ EELTQQPVKK KIPPGPQIIQ QSSSLDDGKK LYAATSSSLY YSDDDKFY-P QLLE---DDQ EELTQQPVKK KVPPGPQIIQ QSSSLDDGKK LYVVTSSSLY YSADDKFY-P QLLE---DDQ EELKQQPVKK KVPPGPQIIQ QSSSLDDGKK LYVVTSSSLY YSADDKFY-P QLLD---DDQ EELDQQPVKK KVAAGPQIIQ QSSSLDDGKK LYVVTSSSLY YSADDKFY-P QLLE---DDQ EELKQQPVKK KVAAGPQIIQ QSSSLDDGKK LYIITSSSLY YSADDKFY-P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- QLLE---DDE EELKQQPVKK KVAAGPQIIQ QSSSLDDGKK LYIITSSSLY YSADDKFY-P QLLE---DDQ EELKQQPVKK KVPPGPQIIQ QSSSLDDGKK IYVVTSSSLY YSDDDKFY-P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- TLLE---DDK DDLEQQPVKK KVPPGPQIIQ QSSSLDDGKK LYVVNSSSLY YSKDDKFY-P TLLE---DDK EELEQQPVKK KIPPGPQIIQ QSSSLDDGKK IYVVSSSSLY YSIDDKFY-P AIIG---EED GGKTQQSIQQ QLRRGPQIIQ QTTTLDDGKK LYVVNSSSLF FSADDKFY-P VVVK---DDD GGETQQSIQQ KLRRGPQIIQ QSSSLDDGKK LYVVNSSSLF FSADDKFY-P KVVG---EED GGNSQQFIKK KLRRGPQIIQ QSSSLDDGKK LYAANSSSLF FSADDRFY-P KVVG---EED GGNTQQFIKK KLRRGPQIIQ QSSSLDDGKK LYAANSSSLF FSAVVVFY-P VVVT---EED DDKEQQYVKK HLRRGPQIIQ QSSSLDDGKK IYVVNSSSLF FSRDDEFYGQ KLLE---GGE KK--PPIVKK RIEEGPQLLQ QSSSLDDGKK LYVVTSSSLY YKKDDDFY-P KLLE---EED HHD-EEIVKK RIEEGPQLLQ QSSSLDDGKK LYVVTSSSLY YKKDDDFY-P ---------- ---------- ----GPAIIQ QSSSVDDGKK LYVVNSSSFY YSTDDKFY-P RLLN---DDP EELKAAPLKK RLLLGPQLLQ QSSSLDDGRR LYVVSSSSLF FSPDDKFY-P VVVKEEEDDK EELKRRPVKK RLEEGPQLLQ QSSSLDDGKK LYVVSSSSLY YSPDDKFY-P ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- -------VVS SSSSWDDGKK VYFFSSSSLL LANDD----- ---------- ---------- -------VVS SSSSWDDGQQ LYYYSSSSLL LANDD----- GGLGGGMKKN NANN----PS GGGGGGFFFV DFFGG----- --HLGGDAAS SSSSYYYPP- GGLGGGMKKN NVNN----PE GGGGGGFFFV DFFGG----- --HLGGDAAS TTSSFYYPP- GGVAAAQLLH HAGG----PD GGGGGGYWWV EFFPPGG--- --HLGGDCCS TTSSFYYPPS GGVGGGEMMN NVGG----GN GGGGGGYFFV SFFPPGG--- --HLGGDCCS TTSSFYYPPS DDRAAAMMMN NVGG----EN GGGGGGFWWV DFFPPGG--- --HLGGDCCS TTSSFYYPPS GGIGGGMKKD DAGG----PN GGGGGGFFFL EWWPPGG--- --HLGGDCCS SSSSYYYPP- GGIGGGMKKD DVNN----PD GGGGGGFFFV DFFGG----- --HLGGDAAS SSSSYFFPP- GGIGGGIKKE EADD----PG GGGGGGFFFT EVVGGGG--- --HLGGDSSS SSSSYYYPPS DDLRRRGVVL LQVVDDDTVN GGGGGGFLLV DFFGGEELLG GPHYGGDCCS SSIIW----- NNLRRRGVVL LQIIDDDTAN GGGGGGFLLV DFFGGEELLG GPHYGGDCCS SSIIW----- DDLRRRGVVL LQIIDDDTVK GGGGGGFLLV DFFGGEELLG GPHYGGDCCS SSIIW----- DDLRRRGVVL LQIIDDDTVK GGGGGGFLLV DFFGGEELLG GPHYGGDCCS SSIIW----- DDLRRRGVVL LQVVDDDTVK GGGGGGFLLV DFFGGEELLG GPHYGGDCCS SSIIW----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDLRRRGVVL LQVVDDDTVK GGGGGGFLLV DFFGGEELLG GPHYGGDCCS SSIIW----- DDLRRRGVVL LQIIDDDTVK GGGGGGFLLV DFFGGEELLG GPHYGGDCCT SSIIW----- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- ---------- DDMKKKGVVL LQIIDDDTEK GGGGGGFLLV DFFGGEEGGG GPHYGGDCCS SSIIW----- DDLKKKGVVL LQIIDDDTKK GGGGGGFLLV DFFGGEEDDG GPHYGGDCCT SSIIW----- GGLEEEGHHL LQIIDDDTEK GGGGGGFFFV DFFGGEEDDG GPHYGGDCCT SSIIW----- KKLEEEGHHL LQIIDDDTEN GGGGGGFFFV DFFGGEEDDG GPHYGGDCCT SSIIW----- EELDDDGHHI IQIIDDDTEK GGGGGGFFFV DFFGGEEEEG GPHYGGDCCT SSIIW----- EEIEEEGHHI IQIIDDDTEK GGGGGGFFFV DFFGGEEDDG GPHYGGDCCT SSIIW----- DDLKKKGHHL LQIIDDDTEK GGGGGGFFFV DFFGGEEEEG GPHYGGDCCT SSIIW----- EEHKKKGTTV VQVVNDDPES GKKKKKFLLI DFFGGIIGGG GPHYGGDCCT SSIIW----- EENRRRGTTL LQIIDDDPIT GHHHHHFLLI DFFGGVVGGG GPHYGGDCCT SSIIW----- NNVKKKGVVL LQIIDDDTEK GGGGGGFLLV DFFGGEENNG GPHFCCDSST SSIIL----- EEMAAAGTTV VQLLDDDVEN GGGGGGFLLV DFFGGEEYYG GPH------- ---------- KKMSSSGHHV VLIIDDDTVN GGGGGGFLLV DFFAAEEYYG GPHYGGDCCT SSIIWAANND ---------- ---------- ---------- ---------- ---------- ---------- ---KKKGDDA AQYYLAAYNW DGGGGGFAAV DFFYYLLLLG G-HFSSALLY SS-------- ---KKKGDDE EQFFLLLYYW DGGGGGFAAI DFFYYEELLG G-HFAAALLY AAPPADDGGN ------- ------- K------ ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- ------- LAREEEE