Pyridoxal Phosphatase function: Difference between revisions
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''Pyridoxal 5'-phosphate + H2O [[Image:Reaction Arrow.jpg]] pyridoxal + phosphate'' | |||
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===Known Functions=== | ===Known Functions=== | ||
'''Amino Acid Metabolism''' | |||
- transamination | |||
- transsulfuration | |||
- selenoamino acid metabolism | |||
- conversion of typtophan to niacin. | |||
'''Gluconeogenesis''' | '''Gluconeogenesis''' | ||
- Catalyse transamination reactions for gluconeogenesis. | |||
- Coenzyme for glycogen phosphorylase, which catalyse glycogenolysis. | |||
'''Neurotransmitter Synthesis''' | '''Neurotransmitter Synthesis''' | ||
Pyridoxal phosphate-dependent enzymes catalyses the biosynthesis of serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid(The four important neurotranmsitters). | - Coenzyme for Pyridoxal phosphate-dependent enzymes, which catalyses the biosynthesis of serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid(The four important neurotranmsitters). | ||
'''Histamine Synthesis''' | '''Histamine Synthesis''' | ||
- Metabolism of histamine. | |||
'''Hemoglobin Synthesis and Function''' | '''Hemoglobin Synthesis and Function''' | ||
- Synthesis of heme | |||
- Binds to two sites on hemoglobin, enhancing the oxygen binding of hemoglobin. | |||
'''Gene Expression''' | '''Gene Expression''' | ||
- Increases or decreases the expression of certain genes. | |||
===Sequence homology=== | ===Sequence homology=== | ||
[[Image:FASTA2.jpg|center|thumb|1000px|Fig 18. Results from FASTA showing five highly related enzymes to 2cfsA]]<BR> | |||
[[Image:FASTA2.jpg| | |||
===Structural Similarities=== | ===Structural Similarities=== | ||
[[Image:Profunc.jpg|left|thumb|1000px|Fig 19. Search results using Interpro for similar protein structure based on motifs.]]<BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR> | [[Image:Profunc.jpg|left|thumb|1000px|Fig 19. Search results using Interpro for similar protein structure based on motifs.]]<BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR> | ||
===Location of Gene on Genome=== | ===Location of Gene on Genome=== | ||
[[Image:neighbourgene.jpg|left|thumb|1000px|Fig 20. Gene location results from Profunc showing two neighbouring genes of 2cfsA with very different sequence but similar function.]]<BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR> | [[Image:neighbourgene.jpg|left|thumb|1000px|Fig 20. Gene location results from Profunc showing two neighbouring genes of 2cfsA with very different sequence but similar function.]]<BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR><BR> | ||
===Functional Expression in Tissue=== | ===Functional Expression in Tissue=== | ||
[[Image:Expressionlev2.jpg|center|thumb|800px|Fig 21. Tissue specific expression of the human PLP phosphatase mRNA. The human multiple tissue expression array was hybridized with human PLP phosphatase-specific DNA probe. Tissue sources for the RNA are indicated below the dot.]] | [[Image:Expressionlev2.jpg|center|thumb|800px|Fig 21. Tissue specific expression of the human PLP phosphatase mRNA. The human multiple tissue expression array was hybridized with human PLP phosphatase-specific DNA probe. Tissue sources for the RNA are indicated below the dot.]] | ||
===Protein-Protein Interactions=== | ===Protein-Protein Interactions=== | ||
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[[Image:String3.jpg|center|thumb|500px|Fig 22. Diagram on protein-protein interaction of 2cfsA.]]<BR> | [[Image:String3.jpg|center|thumb|500px|Fig 22. Diagram on protein-protein interaction of 2cfsA.]]<BR> | ||
Functional Prediction: | |||
Cofactor of HSPD1 and play a role in protein folding. | |||
Coenzyme for asparagine synthetase by interacting with TS11. | |||
[[Pyridoxal Phosphatase| Back To Main Page]] | [[Pyridoxal Phosphatase structure| Back [Structure]]] | [[BIOL3004 2008| Back to BIOL3004 2008]] | [[Pyridoxal Phosphatase| Back To Main Page]] | [[Pyridoxal Phosphatase structure| Back [Structure]]] | [[BIOL3004 2008| Back to BIOL3004 2008]] |
Latest revision as of 07:35, 10 June 2008
Pyridoxal 5'-phosphate + H2O pyridoxal + phosphate
General Annotation
Known Functions
Amino Acid Metabolism
- transamination
- transsulfuration
- selenoamino acid metabolism
- conversion of typtophan to niacin.
Gluconeogenesis
- Catalyse transamination reactions for gluconeogenesis.
- Coenzyme for glycogen phosphorylase, which catalyse glycogenolysis.
Neurotransmitter Synthesis
- Coenzyme for Pyridoxal phosphate-dependent enzymes, which catalyses the biosynthesis of serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid(The four important neurotranmsitters).
Histamine Synthesis
- Metabolism of histamine.
Hemoglobin Synthesis and Function
- Synthesis of heme
- Binds to two sites on hemoglobin, enhancing the oxygen binding of hemoglobin.
Gene Expression
- Increases or decreases the expression of certain genes.
Sequence homology
Structural Similarities
Location of Gene on Genome
Functional Expression in Tissue
Protein-Protein Interactions
Functional Prediction:
Cofactor of HSPD1 and play a role in protein folding.
Coenzyme for asparagine synthetase by interacting with TS11.
Back To Main Page | Back [Structure] | Back to BIOL3004 2008