Pyridoxal Phosphatase function: Difference between revisions
No edit summary |
|||
(7 intermediate revisions by the same user not shown) | |||
Line 1: | Line 1: | ||
''Pyridoxal 5'-phosphate + H2O [[Image:Reaction Arrow.jpg]] pyridoxal + phosphate'' | |||
===General Annotation=== | ===General Annotation=== | ||
Line 8: | Line 9: | ||
===Known Functions=== | ===Known Functions=== | ||
'''Amino Acid Metabolism''' | |||
- transamination | |||
- transsulfuration | |||
- selenoamino acid metabolism | |||
- conversion of typtophan to niacin. | |||
'''Gluconeogenesis''' | '''Gluconeogenesis''' | ||
- Catalyse transamination reactions for gluconeogenesis. | |||
- Coenzyme for glycogen phosphorylase, which catalyse glycogenolysis. | |||
'''Neurotransmitter Synthesis''' | '''Neurotransmitter Synthesis''' | ||
Pyridoxal phosphate-dependent enzymes catalyses the biosynthesis of serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid(The four important neurotranmsitters). | - Coenzyme for Pyridoxal phosphate-dependent enzymes, which catalyses the biosynthesis of serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid(The four important neurotranmsitters). | ||
'''Histamine Synthesis''' | '''Histamine Synthesis''' | ||
- Metabolism of histamine. | |||
'''Hemoglobin Synthesis and Function''' | '''Hemoglobin Synthesis and Function''' | ||
- Synthesis of heme | |||
- Binds to two sites on hemoglobin, enhancing the oxygen binding of hemoglobin. | |||
'''Gene Expression''' | '''Gene Expression''' | ||
- Increases or decreases the expression of certain genes. | |||
===Sequence homology=== | ===Sequence homology=== | ||
[[Image:FASTA2.jpg| | [[Image:FASTA2.jpg|center|thumb|1000px|Fig 18. Results from FASTA showing five highly related enzymes to 2cfsA]]<BR> | ||
===Structural Similarities=== | ===Structural Similarities=== |
Latest revision as of 07:35, 10 June 2008
Pyridoxal 5'-phosphate + H2O pyridoxal + phosphate
General Annotation
Known Functions
Amino Acid Metabolism
- transamination
- transsulfuration
- selenoamino acid metabolism
- conversion of typtophan to niacin.
Gluconeogenesis
- Catalyse transamination reactions for gluconeogenesis.
- Coenzyme for glycogen phosphorylase, which catalyse glycogenolysis.
Neurotransmitter Synthesis
- Coenzyme for Pyridoxal phosphate-dependent enzymes, which catalyses the biosynthesis of serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid(The four important neurotranmsitters).
Histamine Synthesis
- Metabolism of histamine.
Hemoglobin Synthesis and Function
- Synthesis of heme
- Binds to two sites on hemoglobin, enhancing the oxygen binding of hemoglobin.
Gene Expression
- Increases or decreases the expression of certain genes.
Sequence homology
Structural Similarities
Location of Gene on Genome
Functional Expression in Tissue
Protein-Protein Interactions
Functional Prediction:
Cofactor of HSPD1 and play a role in protein folding.
Coenzyme for asparagine synthetase by interacting with TS11.
Back To Main Page | Back [Structure] | Back to BIOL3004 2008