Pyridoxal Phosphatase function: Difference between revisions
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''Pyridoxal 5'-phosphate + H2O [[Image:Reaction Arrow.jpg]] pyridoxal + phosphate'' | |||
===General Annotation=== | ===General Annotation=== | ||
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- transamination | - transamination | ||
- transsulfuration | - transsulfuration | ||
- selenoamino acid metabolism | - selenoamino acid metabolism | ||
- conversion of typtophan to niacin. | - conversion of typtophan to niacin. | ||
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- Catalyse transamination reactions for gluconeogenesis. | - Catalyse transamination reactions for gluconeogenesis. | ||
- Coenzyme for glycogen phosphorylase, which catalyse glycogenolysis. | - Coenzyme for glycogen phosphorylase, which catalyse glycogenolysis. | ||
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- Synthesis of heme | - Synthesis of heme | ||
- Binds to two sites on hemoglobin, enhancing the oxygen binding of hemoglobin. | - Binds to two sites on hemoglobin, enhancing the oxygen binding of hemoglobin. | ||
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'''Gene Expression''' | '''Gene Expression''' | ||
- Increases or decreases the expression of certain genes. | - Increases or decreases the expression of certain genes. | ||
===Sequence homology=== | ===Sequence homology=== | ||
[[Image:FASTA2.jpg| | [[Image:FASTA2.jpg|center|thumb|1000px|Fig 18. Results from FASTA showing five highly related enzymes to 2cfsA]]<BR> | ||
===Structural Similarities=== | ===Structural Similarities=== |
Latest revision as of 07:35, 10 June 2008
Pyridoxal 5'-phosphate + H2O pyridoxal + phosphate
General Annotation
Known Functions
Amino Acid Metabolism
- transamination
- transsulfuration
- selenoamino acid metabolism
- conversion of typtophan to niacin.
Gluconeogenesis
- Catalyse transamination reactions for gluconeogenesis.
- Coenzyme for glycogen phosphorylase, which catalyse glycogenolysis.
Neurotransmitter Synthesis
- Coenzyme for Pyridoxal phosphate-dependent enzymes, which catalyses the biosynthesis of serotonin, epinephrine, norepinephrine and gamma-aminobutyric acid(The four important neurotranmsitters).
Histamine Synthesis
- Metabolism of histamine.
Hemoglobin Synthesis and Function
- Synthesis of heme
- Binds to two sites on hemoglobin, enhancing the oxygen binding of hemoglobin.
Gene Expression
- Increases or decreases the expression of certain genes.
Sequence homology
Structural Similarities
Location of Gene on Genome
Functional Expression in Tissue
Protein-Protein Interactions
Functional Prediction:
Cofactor of HSPD1 and play a role in protein folding.
Coenzyme for asparagine synthetase by interacting with TS11.
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