PROTEIN FUNCTION ANALYSIS

Introduction

SNAP-gamma is located on chromosome 18, location 18p11.22, 10,516,031-10,540,371. This protein belongs to the SNAP family and can be found on the cellular compartment; membrane and peripheral membrane protein (by similarity).

PDB databases of SNAP-gamma (2ifu)

This database contains resources for studying the structures of biological macromolecules and their relationships to sequence and function. The source of SNAP-gamma protein sequence has been obtained from Zebrafish (Brachydanio rerio). Links: http://www.rcsb.org/pdb/explore.do?structureId=2IFU

SNAP-gamma sequence structure of 2ifu domain chain A: http://www.rcsb.org/pdb/explore/sequence.do?structureId=2IFU&chainId=A&domainID=2IFUAa&domainMethod=pdp&structMethod=d&allEntities=&component=domain#2IFUAa

General ProFunc Results for SNAP-gamma:

http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/profunc/GetResults.pl?source=profunc&user_id=ay64&code=075902

Details on ProFunc

SNAP-gamma motifs are expressed during endocytosis/exocytosis process:

http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl

Genes encoded SNAP-gamma are conserved in eukaryotes:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=2838

Mammalian Orthology

http://www.informatics.jax.org/searches/homology_report.cgi?_Organism_key=1&id=MGI:104561

UniProt Gamma-soluble NSF attachment protein on human

http://www.ebi.uniprot.org/uniprot-srv/extendedView.do?proteinId=SNAG_HUMAN&pager.offset=

Entrez Gene from NCBI overview for Gamma-soluble NSF attachment protein on human

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8774&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum

Function by Similarity

This functions are according to Gene Ontology:

1. Biological Function/Process

- intra-Golgi vesicle-mediated transport

- membrane fusion

- protein complex assembly

- protein stabilization

- intracellular protein transport

Links:

http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?ev_code=aca&ont=biological_process&session_id=562b1180740634&view=details&search_constraint=gp&gp=Q99747

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8774&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum#gengene

2. Cellular Component

- membrane fraction

- mitochondrion

- Golgi apparatus

- endoplasmic reticulum

Links:

http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?ev_code=aca&ont=cellular_component&session_id=562b1180740634&view=details&search_constraint=gp&gp=Q99747

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8774&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum#gengene

3. Molecular Function

- protein binding

- intracellular transport activity

Links:

http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?ev_code=aca&ont=molecular_function&session_id=562b1180740634&view=details&search_constraint=gp&gp=Q99747

http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8774&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum#gengene

gene card