PROTEIN FUNCTION ANALYSIS
Introduction
SNAP-gamma is located on chromosome 18, location 18p11.22, 10,516,031-10,540,371. This protein belongs to the SNAP family and can be found on the cellular compartment; membrane and peripheral membrane protein (by similarity).
PDB databases of SNAP-gamma (2ifu)
This database contains resources for studying the structures of biological macromolecules and their relationships to sequence and function. The source of SNAP-gamma protein sequence has been obtained from Zebrafish (Brachydanio rerio). Links: http://www.rcsb.org/pdb/explore.do?structureId=2IFU
SNAP-gamma sequence structure of 2ifu domain chain A: http://www.rcsb.org/pdb/explore/sequence.do?structureId=2IFU&chainId=A&domainID=2IFUAa&domainMethod=pdp&structMethod=d&allEntities=&component=domain#2IFUAa
General ProFunc Results for SNAP-gamma:
SNAP-gamma motifs are expressed during endocytosis/exocytosis process:
http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl
Genes encoded SNAP-gamma are conserved in eukaryotes:
Mammalian Orthology
http://www.informatics.jax.org/searches/homology_report.cgi?_Organism_key=1&id=MGI:104561
UniProt Gamma-soluble NSF attachment protein on human
http://www.ebi.uniprot.org/uniprot-srv/extendedView.do?proteinId=SNAG_HUMAN&pager.offset=
Entrez Gene from NCBI overview for Gamma-soluble NSF attachment protein on human
Function by Similarity
This functions are according to Gene Ontology:
1. Biological Function/Process
- intra-Golgi vesicle-mediated transport
- membrane fusion
- protein complex assembly
- protein stabilization
- intracellular protein transport
Links:
2. Cellular Component
- membrane fraction
- mitochondrion
- Golgi apparatus
- endoplasmic reticulum
Links:
3. Molecular Function
- protein binding
- intracellular transport activity
Links:
